TDMS Study 05058-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ROXARSONE
NTP Experiment-Test: 05058-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
Facility: Southern Research Institute
Chemical CAS #: 121-19-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 22 12 16
Natural Death 1 3 2
Survivors
Terminal Sacrifice 27 35 32
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (50) (50)
Fibrous Histiocytoma 1 (2%)
Neoplastic Nodule 1 (2%)
Mesentery (10) (6) (3)
Pancreas (50) (50) (50)
Pharynx (2) (1)
Squamous Cell Papilloma 1 (50%)
Salivary Glands (50) (47) (48)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Tongue (2)
Squamous Cell Papilloma 1 (50%)
Tooth (2) (1)
Gingiva, Basosquamous Tumor Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (49) (48) (50)
Pheochromocytoma Benign 1 (2%) 2 (4%)
Islets, Pancreatic (50) (50) (50)
Adenoma 1 (2%) 2 (4%)
Pituitary Gland (50) (49) (48)
Pars Distalis, Adenoma 27 (54%) 28 (57%) 18 (38%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50)
Page 2
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Adenoma 8 (16%) 5 (10%) 8 (16%)
C-Cell, Adenoma, Multiple 1 (2%) 1 (2%)
C-Cell, Carcinoma 2 (4%) 4 (8%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (44) (47) (48)
Adenoma 1 (2%) 3 (6%) 5 (10%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (47) (50)
Uterus (50) (49) (50)
Adenocarcinoma 1 (2%) 2 (4%) 1 (2%)
Polyp Stromal 8 (16%) 18 (37%) 12 (24%)
Polyp Stromal, Multiple 2 (4%)
Sarcoma Stromal 1 (2%)
Schwannoma Malignant 1 (2%)
Cervix, Polyp 1 (2%)
Cervix, Squamous Cell Carcinoma 1 (2%)
Vagina (3)
Polyp 1 (33%)
Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (2)
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mandibular (49) (46) (49)
Lymph Node, Mesenteric (50) (50) (46)
Spleen (50) (50) (50)
Thymus (50) (42) (48)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50)
Adenocarcinoma 4 (8%) 1 (2%)
Fibroadenoma 16 (32%) 16 (33%) 17 (34%)
Fibroadenoma, Multiple 5 (10%) 1 (2%) 4 (8%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Skin (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Adenoma, Multiple 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Spinal Cord (50) (50) (49)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (50) (50) (50)
Squamous Cell Carcinoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 14 (28%) 12 (24%) 11 (22%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 47 46
Total Primary Neoplasms 100 98 100
Total Animals with Benign Neoplasms 44 44 42
Total Benign Neoplasms 74 77 77
Total Animals with Malignant Neoplasms 21 20 20
Total Malignant Neoplasms 26 21 23
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 4 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 22 25 27
Natural Death 4 7 5
Survivors
Terminal Sacrifice 24 18 18
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (50) (50) (50)
Adenocarcinoma 1 (2%)
Leiomyosarcoma 2 (4%)
Liver (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hepatocellular Carcinoma 2 (4%) 1 (2%)
Neoplastic Nodule 2 (4%)
Mesentery (2) (4) (6)
Pancreas (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 5 (10%)
Pharynx (2) (1)
Squamous Cell Papilloma 2 (100%) 1 (100%)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (49) (50)
Pheochromocytoma Malignant 4 (8%) 4 (8%) 3 (6%)
Pheochromocytoma Malignant, Multiple 1 (2%) 1 (2%)
Pheochromocytoma Benign 15 (30%) 9 (18%) 10 (20%)
Page 7
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign, Multiple 5 (10%) 6 (12%)
Islets, Pancreatic (50) (50) (50)
Adenoma 3 (6%) 4 (8%)
Carcinoma 2 (4%) 1 (2%)
Parathyroid Gland (46) (47) (45)
Adenoma 1 (2%)
Pituitary Gland (50) (48) (48)
Craniopharyngioma 1 (2%)
Pars Distalis, Adenoma 6 (12%) 13 (27%) 8 (17%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 4 (8%) 2 (4%) 3 (6%)
C-Cell, Carcinoma 1 (2%) 2 (4%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Preputial Gland (49) (48) (48)
Adenoma 7 (14%) 3 (6%) 2 (4%)
Carcinoma 4 (8%)
Prostate (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Seminal Vesicle (3) (5) (3)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 4 (8%) 1 (2%) 9 (18%)
Interstitial Cell, Adenoma, Multiple 42 (84%) 47 (94%) 34 (68%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2) (1)
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (50)
Mediastinal, Sarcoma 1 (2%)
Lymph Node, Mandibular (50) (50) (48)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (50) (49) (48)
Spleen (50) (50) (50)
Sarcoma 1 (2%)
Thymus (49) (49) (47)
Page 8
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (49) (49)
Fibroadenoma 2 (4%) 3 (6%)
Skin (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Fibroma 1 (2%)
Hemangioma 1 (2%)
Keratoacanthoma 4 (8%) 4 (8%) 4 (8%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 3 (6%)
Skeletal Muscle (1) (2)
Osteosarcoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49)
Astrocytoma Malignant 1 (2%)
Schwannoma Malignant 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Cerebellum, Granular Cell Tumor NOS 1 (2%)
Spinal Cord (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Osteosarcoma, Metastatic, Bone 2 (4%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Nose (49) (50) (49)
Respiratory Epithelium, Adenoma 1 (2%)
Page 9
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2) (1) (1)
Adenoma 1 (50%) 1 (100%)
Carcinoma 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Renal Tubule, Adenoma 1 (2%) 2 (4%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 27 (54%) 28 (56%) 25 (50%)
Mesothelioma Malignant 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05058-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ROXARSONE Date: 09/08/94
Route: DOSED FEED Time: 07:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.005% 0.01%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50
Total Primary Neoplasms 141 146 139
Total Animals with Benign Neoplasms 47 50 50
Total Benign Neoplasms 95 96 101
Total Animals with Malignant Neoplasms 36 35 33
Total Malignant Neoplasms 46 50 37
Total Animals with Metastatic Neoplasms 4 2 1
Total Metastatic Neoplasm 8 4 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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