TDMS Study 05058-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/08/94
EXP: 05058 ROXARSONE TIME: 07:49:27
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C56508
CONT: NOI-ES-28024 CAS: 121-19-7
PATHOLOGIST: H. GILES
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/08/94
EXP: 05058 ROXARSONE TIME: 07:49:27
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C56508
CONT: NOI-ES-28024 CAS: 121-19-7
PATHOLOGIST: H. GILES
ROXARSONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 283 538 564 581 584 585 616 625 636 636 |
| 647 651 661 666 671 675 679 679 693 695 |
| 700 703 703 710 716 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.005% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 495 496 535 580 581 593 608 625 629 629 |
| 630 633 633 637 637 656 661 673 679 681 |
| 684 684 685 693 701 705 710 721 722 722 |
| 723 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 534 553 581 581 595 630 634 637 638 647 |
| 651 656 664 666 671 671 677 677 678 681 |
| 683 683 686 690 695 701 714 715 723 724 |
| 727 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ROXARSONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 88.0 74.0 48.0 |
|CONTROL | |
| | |
|0.005% | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 66.0 36.0 |
| | |
| | |
|0.01% | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 90.0 74.0 36.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.005% 0.01% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 48.0% 36.0% 36.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.378 P=0.333 P=0.398 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 639.4 649.0 662.2 |
|NATURAL DEATHS (C) | (17.4) (11.1) ( 8.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.4 677.8 686.3 |
|(STANDARD ERROR) | (11.0) ( 8.9) ( 7.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ROXARSONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 404 485 526 538 582 589 591 630 632 635 |
| 636 647 647 647 686 687 700 701 702 703 |
| 722 722 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.005% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 481 486 498 526 539 544 567 581 602 608 |
| 685 686 700 703 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 395 407 517 530 637 649 677 678 685 686 |
| 697 703 714 723 724 724 727 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ROXARSONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 86.0 72.0 54.0 |
|CONTROL | |
| | |
|0.005% | 100.0 100.0 100.0 100.0 100.0 98.0 88.0 82.0 80.0 70.0 |
| | |
| | |
|0.01% | 100.0 100.0 100.0 100.0 96.0 96.0 92.0 92.0 88.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.005% 0.01% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.0% 70.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.284N P=0.205N P=0.300N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.2 595.6 644.4 |
|NATURAL DEATHS (C) | (17.3) (22.1) (25.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 684.5 689.0 698.6 |
|(STANDARD ERROR) | (10.4) (10.9) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ROXARSONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.005% = 2
0.01% = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 1 3
| 2 1 3 1 1
| 11 3
90 + 2 2 3
| 1 2 21 33
P | 21 113
E | 33
R 80 + 1 1
C | 22 33
E | 13 11
N |
T 70 + 2 2 11
| 2 233
S | 2 1 1
U | 2211
R 60 +
V | 11
I | 22 11
V | 23211
A 50 + 33 11
L | 22 1 1
| 222
|
40 +
|
| 2 2
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 32 obs hidden.
ROXARSONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.005% = 2
0.01% = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 31 2
|
| 313 21
| 3 1 2 3 1
95 +
| 2 3 11
| 21 1 3
|
90 + 22 1 1 3 3
|
| 2 2 3 3
| 2 2 1 1
P 85 +
E | 2 2 11 33
R | 22
C |
E 80 + 2 2 3
N |
T | 1 1 33
| 2 233
S 75 +
U | 223 3
R | 1 1 2 2
V |
I 70 + 11 2 2
V |
A | 11
L | 11
65 +
| 3 3
|
|
60 + 1 1
|
|
|
55 +
| 1 1
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
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