TDMS Study 05063-02 Pathology Tables
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
Facility: TSI Mason Research
Chemical CAS #: 50-33-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M M + + M + + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X X X|
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +|
Submandibular Gland, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Early | |
Invasion | X |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M + + M M + M + + + M + + M + + + M + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + M M + + + + + M + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Luteoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | X X X|
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + M + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Undifferentiated Cell Type | X X|
Inguinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Lumbar, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X X X|
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X X X|
Mediastinal, Sarcoma, Metastatic, | |
Skin | |
Pancreatic, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | X X X|
Renal, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + M + + M + + + + + + + M M + + M + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + M + + M + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X X X X|
__________________________________________________________________________|
Thymus | M + M M M M + M M + + + + + + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + M + + + + + M M M M + + M + + + + + M +|
__________________________________________________________________________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma, Extension | |
Intercostal, Lymphoma Malignant | |
Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Meninges, Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X X X|
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
__________________________________________________________________________|
Lacrimal Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X | 3 |
Hepatocellular Adenoma, Multiple | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 5 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Submandibular Gland, Lymphoma | | |
Malignant Undifferentiated Cell | | |
Type | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Early | | |
Invasion | X | 2 |
Squamous Cell Papilloma | X | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + +| 35 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | M + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Capsule, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + M + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + M M M M + + + + + + M + + + M + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| 44 |
Pars Distalis, Adenoma | X X X X X | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Luteoma | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Undifferentiated Cell | | |
Type | | 3 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leiomyoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sternal, Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Axillary, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 2 |
Inguinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 3 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 3 |
Mediastinal, Sarcoma, Metastatic, | | |
Skin | X | 1 |
Pancreatic, Lymphoma Malignant | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 3 |
Renal, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + M + + + + + M + M + + M M + + M M + M| 34 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + M M + + + M + + + + + + + +| 42 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 6 |
__________________________________________________________________________|____________|
Thymus | M + + + + + M + + + + + + M + + M + + M + + + + +| 37 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + M M M M + M + + + M + + + + + + + M + +| 31 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hemangioma | X | 1 |
Subcutaneous Tissue, Sarcoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
Sarcoma, Extension | X | 1 |
Intercostal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Meninges, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 5 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cell Type | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + M + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + M + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X|
Leukemia, Poorly Differentiated | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
Submandibular Gland, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | X |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M M M M M + |
__________________________________________________________________________|
Pituitary Gland | M + M + + + + + M + |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + M + M + + + + + +|
Cystadenoma | |
Granulosa Cell Tumor Benign | X |
Lymphoma Malignant Lymphocytic | X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Leukemia, Poorly Differentiated | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | X|
Axillary, Lymphoma Malignant Mixed | X |
Inguinal, Carcinoma, Metastatic, Lung| X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X|
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Adenocarcinoma, Metastatic, | |
Uterus | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X|
Lumbar, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X|
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Lymphoma Malignant Lymphocytic| X|
Renal, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + M +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia, Poorly Differentiated | X |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Thymus | + M + + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + + + M |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
Carcinoma, Metastatic, Lung | X |
Sternum, Fibrosarcoma, Deep Invasion | X |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Hindlimb, Carcinoma, Metastatic, Lung| X |
Intercostal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Meninges, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia, Poorly Differentiated | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Leukemia, Poorly Differentiated | X |
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Ureter | + |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + +| 14 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + M M + + + +| 28 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + M M M| 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + M M + +| 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + M +| 15 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hepatocellular Adenoma | X X X | 4 |
Hepatocellular Adenoma, Multiple | | 1 |
Leukemia, Poorly Differentiated | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + +| 8 |
__________________________________________________________________________|____________|
Pancreas | + + M + + + M + + + +| 19 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + + +| 16 |
Submandibular Gland, Lymphoma | | |
Malignant Undifferentiated Cell | | |
Type | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + +| 16 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + M + +| 16 |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + M + +| 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + M + +| 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + +| 15 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + M + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M + +| 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + M + + + + +| 17 |
Pars Distalis, Adenoma | X X X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + +| 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cystadenoma | X | 1 |
Granulosa Cell Tumor Benign | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + M + + + + + +| 15 |
Leukemia, Poorly Differentiated | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + M + +| 24 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Inguinal, Carcinoma, Metastatic, Lung| | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Adenocarcinoma, Metastatic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Uterus | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 2 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 2 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X | 2 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + M M +| 12 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + M +| 18 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 29 |
Hemangiosarcoma | | 1 |
Leukemia, Poorly Differentiated | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Thymus | M + + + + M + M| 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M M| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + +| 16 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + +| 16 |
Carcinoma, Metastatic, Lung | | 1 |
Sternum, Fibrosarcoma, Deep Invasion | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Hindlimb, Carcinoma, Metastatic, Lung| | 1 |
Intercostal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + +| 16 |
Meninges, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + M + +| 21 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia, Poorly Differentiated | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + +| 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + M + +| 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Lung | | 1 |
Leukemia, Poorly Differentiated | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Ureter | | 1 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + +| 16 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + M + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A M + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + A M + M + + + + + + + A M M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + A + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + M + + + + + + + A A + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + A M + + +|
Leukemia Granulocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Leukemia Granulocytic | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + |
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
__________________________________________________________________________|
Pharynx | |
Palate, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M + + + M + M + M + M M + + M + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Adenoma | X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Leukemia Granulocytic | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Periovarian Tissue, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | |
__________________________________________________________________________|
Uterus | + + + + M + + + + + + + + + + + M + + + + + + + +|
Hemangioma | X |
Leiomyoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Leukemia Granulocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Pancreatic, Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M + + M + M + + M + M + + + + + + M|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + M M + + + + + + + + + M + M + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | M + + + M + + + + + M + M + + M + + + M M + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M + + + M + M M M + M M M M M + M M M + +|
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + + + + M + +|
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Intercostal, Lymphoma Malignant | |
Histiocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Mediastinum, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Lymphoma | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Malignant Histiocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + M + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + M + + + M + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + M| 47 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + + + + + + M + + + + + + + + + M + +| 40 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + M M + +| 44 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + M M + +| 45 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | X | 4 |
Hepatocellular Adenoma, Multiple | X X X | 3 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + +| 4 |
Fibrosarcoma, Metastatic, Skin | X| 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Submandibular Gland, Lymphoma | | |
Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M + + + + + + + + + M + + + M M M + + M| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Pars Distalis, Adenoma | X | 3 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + M + + + + + + + M + + + + + + + + +| 47 |
Granulosa Cell Tumor Benign | X | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Undifferentiated Cell | | |
Type | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemangioma | | 1 |
Leiomyoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mediastinal, Leukemia Granulocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X | 2 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | X X | 2 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M M + + + M M + M M + + + M + + + + + + +| 30 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M M M + + + + + + + + + + + + + + + + + M| 41 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + + M + + + + + + + + + + + + + + + + M + M| 39 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + M M M + M + M M M M + + + M + + M M + M| 23 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Subcutaneous Tissue, Fibrosarcoma | X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Intercostal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 3 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Mediastinum, Lymphoma Malignant Mixed| X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + M M + + + M + + + + + M + + +| 41 |
Nasolacrimal Duct, Lymphoma | | |
Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | X| 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosarcoma, Metastatic, Skin | X| 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + M + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + M + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + M + + + + + + + + M + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + M + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M M + + + M M M + M + + + M M + + M|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Adenocarcinoma | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + |
Basosquamous Tumor NOS | X |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Lymphoma Malignant | |
Histiocytic | |
Bronchial, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + + + M + M M M + + + + M M M + M M|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + M + + + + + + + + + + + + + + + M +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + M A + M M M + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Scapula, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Thoracic, Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic | X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
__________________________________________________________________________|
Eye | I |
Lids, Fibrosarcoma, Metastatic, Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + M + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X X X | 8 |
Hepatocellular Adenoma | X X X | 6 |
Hepatocellular Adenoma, Multiple | X | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + M + M M M + M M + + + M M M + M + + M| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 10 |
Basosquamous Tumor NOS | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Bronchial, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + M + M + + M M M M + M M M M + + + + +| 27 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + M +| 45 |
Lymphoma Malignant Histiocytic | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M M + + M + +| 41 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 3 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Scapula, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Thoracic, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Hepatocellular Carcinoma, Metastatic | X | 4 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Fibrosarcoma | X | 1 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Lids, Fibrosarcoma, Metastatic, Ear | X | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Urethra | + + + +| 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + M |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + |
__________________________________________________________________________|
Salivary Glands | + + M |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + |
__________________________________________________________________________|
Pituitary Gland | + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thyroid Gland | + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + |
__________________________________________________________________________|
Testes | + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant Mixed| X X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Pancreatic, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + M + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M |
__________________________________________________________________________|
Skin | + + + + + + |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Nose | + + |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + M + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 4 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 9 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 2 |
Hepatocellular Carcinoma | X X | 3 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X X X | 9 |
Hepatocellular Adenoma, Multiple | X X X | 3 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 4 |
__________________________________________________________________________|____________|
Stomach | + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + +| 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + +| 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + +| 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 14 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + | 5 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 6 |
__________________________________________________________________________|____________|
Testes | + + + | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 27 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 3 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + | 20 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 20 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cell Type | X X X | 3 |
__________________________________________________________________________|____________|
Thymus | + + | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + + + +| 11 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 14 |
Alveolar/Bronchiolar Adenoma | X X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + | 3 |
__________________________________________________________________________|____________|
Trachea | + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 6 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Mixed | X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + M M + + + + + + + + M + + + + M + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + M + + + + + M + M + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Multiple | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + + + + M M + + + + M + + M M + + + +|
__________________________________________________________________________|
Pituitary Gland | M + M + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M + + M + + M + M M M + M + M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + M + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | M + + + M + + M M M + + + + + M + + M + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic | X X |
__________________________________________________________________________|
Nose | + + + + + + M + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Hepatocellular | |
Carcinoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M M + + M + + + + + + + + M M + + + + M +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + M + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma, Multiple | | 1 |
Hepatocellular Carcinoma | X X X X X X | 11 |
Hepatocellular Adenoma | X X X X X X X X X X | 15 |
Hepatocellular Adenoma, Multiple | X X| 8 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + M + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + M + + + + + + + + + M +| 48 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + M M + + + + + + M + M + M M + + +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + M + + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | | 1 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + | 11 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M M + + M + + + + M + + M + M M + + + + M + +| 23 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thymus | M + M + M + M M + + + + + + + M + + + M + M + + +| 34 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Fibrosarcoma | X X X X X X X| 7 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05063-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:13:19
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X X | 4 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic | X X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Renal Tubule, Hepatocellular | | |
Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urethra | + + + | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + M +| 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
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---------- END OF REPORT ----------
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