TDMS Study 05063-02 Pathology Tables
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
Facility: TSI Mason Research
Chemical CAS #: 50-33-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M M + + M + + + + + + + + M + + + + + M + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 2 1 1 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelium, Hyperplasia | |
Muscularis, Inflammation, Chronic | |
Active | 2 |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Mesothelium, Hyperplasia | |
Serosa, Fibrosis | 2 |
Serosa, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + A + +|
Lymphoid Nodule, Hyperplasia | 2 |
Mesothelium, Hyperplasia | |
Mucosa, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelium, Hyperplasia | |
Serosa, Inflammation, Chronic Active | 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Congestion | 2 |
Eosinophilic Focus | 1 |
Fatty Change | 2 2 2 |
Hematopoietic Cell Proliferation | 1 3 1 2 2 2 2 3 3 3 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | 1 |
Necrosis, Coagulative | 1 3 2 1 1 |
Vacuolization Cytoplasmic, Diffuse | 4 |
Periportal, Inflammation, Chronic | 2 1 1 1 2 1 1 2 1 |
Serosa, Inflammation, Acute | 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Fatty Change | |
Fibrosis | 4 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 4 1 2 |
Duct, Dilatation | |
Serosa, Fibrosis | |
Serosa, Inflammation, Acute | 2 |
Serosa, Inflammation, Chronic Active | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +|
Parotid Gland, Inflammation, Chronic | 1 1 |
Sublingual Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic | 1 2 |
Inflammation, Chronic Active, | |
Necrotizing | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 2 |
Inflammation, Chronic Active | 2 1 2 |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + |
Dysplasia | |
Incisor, Abscess | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | |
Necrosis, Focal | |
Coronary Artery, Perivascular, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Acute | |
Coronary Artery, Perivascular, | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Chronic Active| 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 |
Hematopoietic Cell Proliferation | 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M + + M M + M + + + M + + M + + + M + M + M|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + M M + + + + + M + + + + + + + + + +|
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 3 2 2 1 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 4 4 4 4 4 4 |
Cyst | 2 2 X 3 4|
Hemorrhage | 2 |
Mineralization | 1 |
Periovarian Tissue, Cyst | 3 3 |
Periovarian Tissue, Inflammation, | |
Chronic | 1 2 2 2 2 |
Periovarian Tissue, Inflammation, | |
Chronic Active | 3 |
Serosa, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Oviduct | + + |
Inflammation, Acute, Hemorrhagic | |
Inflammation, Acute | 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Hydrometra | 2 |
Inflammation, Acute | 2 1 3 2 1 2 2 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia | 2 3 2 2 3 2 2 4 2 2 3 2 3 2 2 2 2 3 3 2 2 3 2 4 3|
Muscularis, Congestion | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Myelofibrosis | 2 2 3 2 2 1 2 2 3 2 2 2 1 1 2 1 3 2 2 1|
Myeloid Cell, Hyperplasia | 4 4 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + M + + + + + + + + + + + + + +|
Lumbar, Bacterium | |
Lumbar, Hyperplasia, Plasma Cell | 2 4 4 2 |
Lumbar, Inflammation, Chronic Active | 2 1 |
Mediastinal, Congestion | |
Mediastinal, Depletion Lymphoid | |
Mediastinal, Hemorrhage | 2 1 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 4 2 3 3 4 |
Mediastinal, Inflammation, Acute | 3 |
Pancreatic, Angiectasis | |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Plasma Cell | 2 |
Pancreatic, Inflammation, Acute | 1 |
Renal, Bacterium | |
Renal, Hemorrhage | |
Renal, Hyperplasia, Plasma Cell | 3 2 4 3 3 2 |
Renal, Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + M + + M + + + + + + + M M + + M + +|
Depletion Lymphoid | 2 |
Hyperplasia, Plasma Cell | 1 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + M + + M + + M + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 |
Congestion | 1 |
Depletion Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 3 |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 |
Inflammation, Acute | 1 1 |
Inflammation, Chronic Active | |
Serosa, Congestion | |
Serosa, Fibrosis | 2 |
Serosa, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 3 3 |
Hematopoietic Cell Proliferation | 3 4 4 2 2 3 2 4 2 4 2 3 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 3 2 2 |
Necrosis, Coagulative | 2 |
Capsule, Abscess | 4 |
Capsule, Fibrosis | 4 |
Capsule, Inflammation, Acute | 1 |
__________________________________________________________________________|
Thymus | M + M M M M + M M + + + + + + + + + + + + + + M +|
Depletion Lymphoid | 2 3 3 4 |
Hemorrhage | 1 |
Inflammation, Acute | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + M + + + + + M M M M + + M + + + + + M +|
Galactocele | 2 |
Hyperplasia | 1 |
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Hemorrhage | 3 |
Infarct, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 1 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
Leukocytosis | 4 |
Artery, Hyperplasia | |
Artery, Thrombosis | 1 |
Mediastinum, Inflammation, Chronic | |
Active | |
Peribronchiolar, Inflammation, | |
Chronic | |
Perivascular, Inflammation, Acute | 4 |
Perivascular, Inflammation, Chronic | 2 |
Perivascular, Inflammation, Chronic | |
Active | |
Pleura, Inflammation, Acute | 3 |
Pleura, Inflammation, Chronic | |
Pleura, Inflammation, Chronic Active,| |
Hemorrhagic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Inflammation, Acute | 1 2 2 |
Mucosa, Glands, Inflammation, Acute | 1 1 1 1 1 1 2 1 |
Mucosa, Glands, Inflammation, | |
Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 1| 0| 1| 4| 1| 3| 3| 0| 3| 3| 3| 0| 1| 9| 6| 2| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 5| 2| 0| 1| 0| 3| 8| 0| 7| 7| 7| 4| 3| 6| 3| 9| 8| 1| 8| 8| 7| 8| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Bacterium | |
Glomerulosclerosis | 2 3 4 2 2 3 4 |
Inflammation, Chronic | 2 1 2 2 1 1 3 1 2 1 2 1 2 2 2 1 1 2 2 2 1 2 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 1 |
Necrosis, Coagulative, Focal | |
Capsule, Inflammation, Acute | 1 |
Proximal Convoluted Renal Tubule, | |
Atrophy | 2 |
Proximal Convoluted Renal Tubule, | |
Regeneration | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 |
Serosa, Inflammation, Acute | 1 |
Serosa, Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 44 |
Inflammation, Acute | 3 3 3 | 4 2.5|
Inflammation, Chronic | 1 1 1| 7 1.1|
Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Serosa, Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelium, Hyperplasia | 1 | 1 1.0|
Muscularis, Inflammation, Chronic | | |
Active | | 1 2.0|
Serosa, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Serosa, Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Mesothelium, Hyperplasia | 1 | 1 1.0|
Serosa, Fibrosis | | 1 2.0|
Serosa, Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + A + +| 46 |
Lymphoid Nodule, Hyperplasia | 2 2 | 3 2.0|
Mesothelium, Hyperplasia | 1 1 | 2 1.0|
Mucosa, Vacuolization Cytoplasmic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Mesothelium, Hyperplasia | 1 1 1 | 3 1.0|
Serosa, Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 1.0|
Congestion | 1 | 2 1.5|
Eosinophilic Focus | | 1 1.0|
Fatty Change | 2 1 | 5 1.8|
Hematopoietic Cell Proliferation | 3 2 3 3 3 2 1 1| 19 2.2|
Inflammation, Acute | 3 2 | 3 2.3|
Inflammation, Chronic | 1 1 2 1 2 1 1 1 1 1| 12 1.3|
Inflammation, Chronic Active | | 1 1.0|
Necrosis, Coagulative | 1 1 1 | 8 1.4|
Vacuolization Cytoplasmic, Diffuse | | 1 4.0|
Periportal, Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 19 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Serosa, Inflammation, Acute | 3 3 | 5 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 3 2 3 2 | 5 2.6|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 1.5|
Fatty Change | 1 | 1 1.0|
Fibrosis | | 1 4.0|
Inflammation, Acute | 2 | 2 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1| 17 1.0|
Inflammation, Chronic Active | 2 | 5 2.2|
Duct, Dilatation | 4 | 1 4.0|
Serosa, Fibrosis | 3 3 | 2 3.0|
Serosa, Inflammation, Acute | 3 2 3 4 | 5 2.8|
Serosa, Inflammation, Chronic Active | 1 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Parotid Gland, Inflammation, Chronic | | 2 1.0|
Sublingual Gland, Inflammation, | | |
Chronic | 1 1 | 3 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1| 26 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 | 3 2.0|
Hyperkeratosis | 2 2 2 | 4 2.0|
Inflammation, Chronic | 2 | 3 1.7|
Inflammation, Chronic Active, | | |
Necrotizing | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 1 1 1 1 1| 13 1.1|
Inflammation, Chronic Active | 1 2 | 5 1.6|
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + +| 35 |
Dysplasia | 3 | 1 3.0|
Incisor, Abscess | 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 1 | 1 1.0|
Bacterium | 4 | 1 4.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Acute | 2 | 2 3.0|
Inflammation, Chronic | 1 1 | 5 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Necrosis, Focal | 1 | 1 1.0|
Coronary Artery, Perivascular, | | |
Inflammation, Acute | 2 | 1 2.0|
Coronary Artery, Perivascular, | | |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | M + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Capsule, Inflammation, Chronic Active| 3 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Angiectasis | 1 1 | 2 1.0|
Cyst | 1 | 2 1.5|
Hematopoietic Cell Proliferation | 2 | 3 1.3|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + M + + M + + + + + + + + + + +| 47 |
Angiectasis | 1 | 1 1.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + M M M M + + + + + + M + + + M + +| 31 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| 44 |
Pars Distalis, Congestion | 1 | 1 1.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 3 2 3 1 2 1 2 | 16 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 1 | 1 1.0|
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicle, Cyst | 2 | 2 2.0|
Follicular Cell, Hyperplasia | 1 2 2 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 4 4 4 4 3 4 4 4 | 19 3.9|
Cyst | 2 2 | 7 2.5|
Hemorrhage | 2 | 2 2.0|
Mineralization | | 1 1.0|
Periovarian Tissue, Cyst | 2 2 | 4 2.5|
Periovarian Tissue, Inflammation, | | |
Chronic | 1 1 2 1 2 1 1 4 2| 14 1.7|
Periovarian Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
Serosa, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | + + + + + + | 8 |
Inflammation, Acute, Hemorrhagic | 2 | 1 2.0|
Inflammation, Acute | 4 4 4 2 | 6 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 4 | 3 3.7|
Hydrometra | | 1 2.0|
Inflammation, Acute | 2 3 1 2 1 2 4 2 2 4 3| 19 2.2|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Endometrium, Hyperplasia | 4 2 3 2 3 3 2 3 3 1 2 2 3 3 3 2 3 3 3 2 2 2 2 4 3| 50 2.5|
Muscularis, Congestion | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 1 | 1 1.0|
Myelofibrosis | 1 1 1 1 3 1 1 1 2 1 1 3 2 2 2 2 3 2 3 1 1 3| 42 1.8|
Myeloid Cell, Hyperplasia | 3 | 4 3.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Lumbar, Bacterium | 4 | 1 4.0|
Lumbar, Hyperplasia, Plasma Cell | 3 2 1 3 3 | 9 2.7|
Lumbar, Inflammation, Chronic Active | 3 4 | 4 2.5|
Mediastinal, Congestion | 2 | 1 2.0|
Mediastinal, Depletion Lymphoid | 4 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage | | 2 1.5|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 6 3.2|
Mediastinal, Inflammation, Acute | 3 3 4 | 4 3.3|
Pancreatic, Angiectasis | 2 | 1 2.0|
Pancreatic, Hemorrhage | 4 | 1 4.0|
Pancreatic, Hyperplasia, Plasma Cell | 2 | 2 2.0|
Pancreatic, Inflammation, Acute | 3 | 2 2.0|
Renal, Bacterium | 4 | 1 4.0|
Renal, Hemorrhage | 4 | 1 4.0|
Renal, Hyperplasia, Plasma Cell | 4 3 3 2 3 | 11 2.9|
Renal, Inflammation, Chronic Active | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + M + + + + + M + M + + M M + + M M + M| 34 |
Depletion Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 2 3 | 3 2.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + M M + + + M + + + + + + + +| 42 |
Angiectasis | 1 | 5 1.2|
Congestion | | 1 1.0|
Depletion Lymphoid | 2 | 2 2.5|
Hemorrhage | 1 | 2 2.0|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 3 2 2| 4 2.3|
Hyperplasia, Plasma Cell | | 2 2.0|
Inflammation, Acute | 4 | 3 2.0|
Inflammation, Chronic Active | 1 3 | 2 2.0|
Serosa, Congestion | 1 | 1 1.0|
Serosa, Fibrosis | | 1 2.0|
Serosa, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Depletion Lymphoid | 1 3 | 4 2.5|
Hematopoietic Cell Proliferation | 4 3 3 3 2 3 3 3 2 4 2 | 23 2.9|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 1 1 2 2 2 1 | 9 1.8|
Necrosis, Coagulative | | 1 2.0|
Capsule, Abscess | | 1 4.0|
Capsule, Fibrosis | | 1 4.0|
Capsule, Inflammation, Acute | 3 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + + + + + M + + + + + + M + + M + + M + + + + +| 37 |
Depletion Lymphoid | 3 4 3 1 3 | 9 2.9|
Hemorrhage | 1 1 | 3 1.0|
Inflammation, Acute | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + M M M M + M + + + M + + + + + + + M + +| 31 |
Galactocele | | 1 2.0|
Hyperplasia | 1 | 2 1.0|
Infiltration Cellular, Mixed Cell | | 1 1.0|
Inflammation, Chronic | 1 | 3 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Necrotizing | 3 | 2 3.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 1 | 1 1.0|
Hemorrhage | 1 | 2 2.0|
Infarct, Multifocal | | 1 3.0|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 1 | 2 1.5|
Hemorrhage | 1 3 | 6 1.3|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Leukocytosis | 2 2 | 3 2.7|
Artery, Hyperplasia | 1 | 1 1.0|
Artery, Thrombosis | | 1 1.0|
Mediastinum, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Active | 3 | 1 3.0|
Peribronchiolar, Inflammation, | | |
Chronic | 2| 1 2.0|
Perivascular, Inflammation, Acute | 2 2 2 | 4 2.5|
Perivascular, Inflammation, Chronic | 1 2| 3 1.7|
Perivascular, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Pleura, Inflammation, Acute | 2 | 2 2.5|
Pleura, Inflammation, Chronic | 2| 1 2.0|
Pleura, Inflammation, Chronic Active,| | |
Hemorrhagic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Inflammation, Acute | 3 | 4 2.0|
Mucosa, Glands, Inflammation, Acute | 1 1 1 1 1 2 1 1 1 1| 18 1.1|
Mucosa, Glands, Inflammation, | | |
Chronic Active | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 3 1 | 5 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Inflammation, Acute, Necrotizing | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 2 | 1 2.0|
Bacterium | 2 | 1 2.0|
Glomerulosclerosis | 2 3 1 1 2 2 3 2 | 15 2.4|
Inflammation, Chronic | 2 2 2 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2| 44 1.5|
Inflammation, Chronic Active | 2 | 1 2.0|
Metaplasia, Osseous | 1 | 2 1.0|
Necrosis, Coagulative, Focal | 2 | 1 2.0|
Capsule, Inflammation, Acute | | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| |
DAY ON TEST | 7| 1| 2| 2| 8| 3| 6| 3| 3| 7| 3| 5| 3| 3| 1| 3| 8| 3| 5| 3| 3| 3| 9| 3| 3| |
| 2| 8| 6| 6| 8| 9| 8| 9| 9| 0| 7| 9| 9| 8| 7| 9| 5| 7| 2| 1| 9| 9| 3| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Proximal Convoluted Renal Tubule, | | |
Regeneration | 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2| 38 1.1|
Inflammation, Chronic Active | | 1 2.0|
Serosa, Inflammation, Acute | 2 | 2 1.5|
Serosa, Inflammation, Chronic Active | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + M + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + M + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Eosinophilic Focus | 1 |
Fatty Change | 2 2 2 1 1 2 |
Hematopoietic Cell Proliferation | 4 2 2 |
Hemorrhage | 2 2 1|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 1 2 1|
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 2 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1|
Vacuolization Cytoplasmic, Diffuse | 1 |
Periportal, Inflammation, Chronic | 2 1 2 1 1 1 1 1 1 |
Serosa, Inflammation, Acute | 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Abscess | |
Inflammation, Acute | |
Inflammation, Chronic Active | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + |
Abscess | 4 4 |
Inflammation, Acute | |
Inflammation, Chronic | |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
Submandibular Gland, Atrophy | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Mineralization | 1 |
Epicardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Congestion | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M M M M M + |
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | M + M + + + + + M + |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Cyst | |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + M + M + + + + + +|
Abscess | 4 |
Angiectasis | 3 |
Cyst | 1 2 1 3 |
Pigmentation | 2 |
Periovarian Tissue, Cyst | 2 3 |
Periovarian Tissue, Hemorrhage | |
Periovarian Tissue, Inflammation, | |
Acute | |
Periovarian Tissue, Inflammation, | |
Chronic Active | |
Periovarian Tissue, Necrosis | 3 |
Periovarian Tissue, Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 |
Inflammation, Acute | 4 1 |
Necrosis, Coagulative | |
Pigmentation | |
Endometrium, Hyperplasia | 3 4 4 4 2 3 3 3 3 3 3 2 1 4 3 3 3 2 3 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Congestion | |
Myelofibrosis | 1 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Bronchial, Inflammation, Chronic | |
Active | 3 |
Lumbar, Hemorrhage | |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Abscess | 2 |
Mediastinal, Depletion Lymphoid | 4 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Inflammation, Acute | |
Pancreatic, Hemorrhage | 1 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 3 |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + M +|
Depletion Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + +|
Abscess | |
Angiectasis | 2 |
Depletion Lymphoid | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Inflammation, Acute, Necrotizing | 3 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Congestion | 2 |
Depletion Lymphoid | 2 4 3 |
Hematopoietic Cell Proliferation | 4 2 2 3 |
Hyperplasia, Lymphoid | |
Capsule, Inflammation, Acute | |
Capsule, Inflammation, Chronic Active| 1 |
__________________________________________________________________________|
Thymus | + M + + + M + + |
Cyst | |
Depletion Lymphoid | 3 2 4 2 |
Hemorrhage | |
Necrosis | 4 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + + + M |
__________________________________________________________________________|
Skin | + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Intercostal, Inflammation, Acute | |
Thoracic, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Thalamus, Mineralization | 1 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 2 |
Perivascular, Inflammation, Chronic | |
Pleura, Inflammation, Acute | |
Pleura, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Nose | + + + + + + + |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Glomerulosclerosis | 3 4 |
Inflammation, Chronic | 1 2 1 1 1 2 1 1 1 1 2 2 2 2 1 2 2 1 |
Metaplasia, Osseous | 2 |
Papilla, Inflammation, Acute, | |
Necrotizing | 4 |
Proximal Convoluted Renal Tubule, | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 0| 1| 3| 3| 3| 3| 3| 3| 3| 4| 0| 3| 6| 3| 9| 3| 2| 3| 4| 3| 3| 6| 7| 3| 3|
| 1| 1| 3| 3| 3| 3| 0| 3| 3| 5| 5| 3| 3| 3| 1| 3| 3| 3| 6| 3| 3| 8| 8| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Atrophy | 2|
Proximal Convoluted Renal Tubule, | |
Regeneration | 1 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + +| 14 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + M M + + + +| 28 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + M M M| 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + M M + +| 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M +| 15 |
Serosa, Inflammation, Acute | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + M +| 15 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Degeneration | | 1 1.0|
Eosinophilic Focus | | 1 1.0|
Fatty Change | | 6 1.7|
Hematopoietic Cell Proliferation | | 3 2.7|
Hemorrhage | 1 1 2 | 6 1.5|
Inflammation, Chronic | 2 2 2 1 1 1 | 7 1.6|
Inflammation, Chronic Active | 2 1 1 1 | 7 1.3|
Mixed Cell Focus | 2 2 | 3 2.0|
Necrosis, Coagulative | 1 1 1 1 1 | 14 1.1|
Pigmentation | | 2 1.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 2 1.5|
Periportal, Inflammation, Chronic | 2 1 1 1 1 2 1| 16 1.3|
Serosa, Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 8 |
Abscess | 4| 1 4.0|
Inflammation, Acute | 1 1 3 | 3 1.7|
Inflammation, Chronic Active | | 1 4.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + M + + + M + + + +| 19 |
Abscess | | 2 4.0|
Inflammation, Acute | 2| 1 2.0|
Inflammation, Chronic | 1 1 | 2 1.0|
Serosa, Inflammation, Acute | 3 1 3 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + + +| 16 |
Submandibular Gland, Atrophy | 1 | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + M + +| 16 |
Mineralization | | 1 1.0|
Epicardium, Inflammation, Acute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + M + +| 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + M + +| 15 |
Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + +| 15 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + M + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M + +| 8 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + M + + + + +| 17 |
Pars Distalis, Angiectasis | 3 2 2 | 4 2.3|
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + +| 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 2 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Abscess | 4 4 4| 4 4.0|
Angiectasis | | 1 3.0|
Cyst | 2 2 2 2 1 | 9 1.8|
Pigmentation | 2 2 2 2 1 | 6 1.8|
Periovarian Tissue, Cyst | 3 3 1 | 5 2.4|
Periovarian Tissue, Hemorrhage | 4 | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Acute | 2 | 1 2.0|
Periovarian Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Chronic Active | 4| 1 4.0|
Periovarian Tissue, Necrosis | | 1 3.0|
Periovarian Tissue, Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 4| 4 4.0|
Inflammation, Acute | 2 1 1 | 5 1.8|
Necrosis, Coagulative | 4 | 1 4.0|
Pigmentation | 2 | 1 2.0|
Endometrium, Hyperplasia | 3 4 3 4 3 3 3 4 1 1 3 2 3 3 3 2 2 4 3 1 3 | 42 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + M + + + + + +| 15 |
Congestion | 4 | 1 4.0|
Myelofibrosis | | 1 1.0|
Myeloid Cell, Hyperplasia | 3 4| 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + M + +| 24 |
Bronchial, Inflammation, Chronic | | |
Active | | 1 3.0|
Lumbar, Hemorrhage | 4 | 1 4.0|
Lumbar, Hyperplasia, Lymphoid | 3| 1 3.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Abscess | | 1 2.0|
Mediastinal, Depletion Lymphoid | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | 4| 1 4.0|
Mediastinal, Inflammation, Acute | 2 4| 2 3.0|
Pancreatic, Hemorrhage | | 1 1.0|
Renal, Hyperplasia, Lymphoid | 3| 1 3.0|
Renal, Hyperplasia, Plasma Cell | 2 3 | 3 2.7|
Renal, Inflammation, Acute | 3| 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + M M +| 12 |
Depletion Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + M +| 18 |
Abscess | 4 | 1 4.0|
Angiectasis | | 1 2.0|
Depletion Lymphoid | | 1 2.0|
Hyperplasia, Lymphoid | 4| 1 4.0|
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Acute, Necrotizing | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 3.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 29 |
Angiectasis | | 1 1.0|
Congestion | | 1 2.0|
Depletion Lymphoid | 1 1 3 | 6 2.3|
Hematopoietic Cell Proliferation | 2 2 4 3| 8 2.8|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Capsule, Inflammation, Acute | 3 | 1 3.0|
Capsule, Inflammation, Chronic Active| | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M + M| 11 |
Cyst | 1 | 1 1.0|
Depletion Lymphoid | 3 3 3 | 7 2.9|
Hemorrhage | 1 | 1 1.0|
Necrosis | 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M M| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Intercostal, Inflammation, Acute | 1 | 1 1.0|
Thoracic, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + +| 16 |
Thalamus, Mineralization | 1 1| 4 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + M + +| 21 |
Congestion | 4 | 2 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Perivascular, Inflammation, Chronic | 2 2 | 2 2.0|
Pleura, Inflammation, Acute | 4 | 1 4.0|
Pleura, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + +| 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 2| 7| 0| 7| 7| 4| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 1| 0| 3| 3| 3| 3| 3| 3| 3| 1| 4| 7| 3| 4| 3| 3| 0| 3| 4| 3| 3| 3| 3| 3| 5| |
| 2| 9| 3| 3| 3| 5| 5| 5| 5| 1| 4| 5| 5| 3| 5| 0| 4| 5| 4| 5| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Acute | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + M + +| 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | | 1 2.0|
Glomerulosclerosis | | 2 3.5|
Inflammation, Chronic | 1 2 2 2 1 1 1 2 1 1 1 1 1 1 2 1 1 2 1 1 1| 39 1.4|
Metaplasia, Osseous | | 1 2.0|
Papilla, Inflammation, Acute, | | |
Necrotizing | | 1 4.0|
Proximal Convoluted Renal Tubule, | | |
Atrophy | 2 | 2 2.0|
Proximal Convoluted Renal Tubule, | | |
Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + +| 16 |
Inflammation, Chronic | 1 1 1 1| 6 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + M + + + + + + + + M + + + + +|
Inflammation, Acute | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Acute | 2 1 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A M + + + + + + + + + +|
Mesothelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + A + + + +|
Inflammation, Acute | 3 |
Epithelium, Hyperplasia | |
Mesothelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + A M + M + + + + + + + A M M + +|
Mesothelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + A + A + +|
Mesothelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + M + + + + + + + A A + + +|
Mesothelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + A M + + +|
Hemorrhage | 2 |
Mesothelium, Hyperplasia | |
Serosa, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Clear Cell Focus | 1 |
Congestion | |
Hematopoietic Cell Proliferation | 1 2 1 |
Hemorrhage | |
Inflammation, Chronic | 1 2|
Necrosis, Coagulative | 1 1 1 2 1 1 1 |
Periportal, Inflammation, Chronic | 1 2 2 1 1 1 2 1 1 1 |
Serosa, Inflammation, Acute | 3 1 3 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 2 |
Inflammation, Chronic | 1 2 1 1 1 1 1 |
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Serosa, Inflammation, Acute | 3 |
Serosa, Inflammation, Chronic Active | 4 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic | 1 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 2 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active | |
Inflammation, Chronic Active, | |
Necrotizing | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Chronic Active| 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M + + + M + M + M + M M + + M + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 1 2 1 2 1 1 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Inflammation, Chronic | |
Ultimobranchial Cyst | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 4 |
Angiectasis | 2 |
Cyst | 2 1 3 2 X 3 3 2 2|
Necrosis, Coagulative | |
Periovarian Tissue, Cyst | |
Periovarian Tissue, Inflammation, | |
Chronic | 2 2 2 |
Periovarian Tissue, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Uterus | + + + + M + + + + + + + + + + + M + + + + + + + +|
Abscess | 4 |
Hydrometra | |
Inflammation, Acute | 1 2 1 2 3 |
Inflammation, Chronic Active | 1 2 |
Endometrium, Hyperplasia | 2 3 2 3 3 3 3 2 3 1 3 2 2 1 3 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 4 4 4 |
Hypoplasia | 4 2 3 |
Myelofibrosis | 2 1 1 1 1 2 3 1 2 1 1 2|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Plasma Cell | 3 |
Lumbar, Inflammation, Acute | |
Mediastinal, Abscess | |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Mediastinal, Inflammation, Acute | 3 1 |
Mediastinal, Inflammation, Chronic | |
Active | |
Pancreatic, Hyperplasia, Plasma Cell | 2 |
Renal, Hyperplasia, Plasma Cell | 2 2 3 3 |
Renal, Inflammation, Acute | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M + + M + M + + M + M + + + + + + M|
Depletion Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + M M + + + + + + + + + M + M + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +|
Congestion | |
Depletion Lymphoid | 3 3 3 |
Hematopoietic Cell Proliferation | 1 4 3 1 2 |
Hyperplasia, Lymphoid | 1 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Thymus | M + + + M + + + + + M + M + + M + + + M M + + + +|
Depletion Lymphoid | 3 3 4 4 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M + + + M + M M M + M M M M M + M M M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + + + + M + +|
Inflammation, Acute, Necrotizing | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Thoracic, Inflammation, Acute | 2 |
Thoracic, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Cerebellum, Inflammation, Chronic | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Congestion | 1 |
Hemorrhage | 2 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 0| 0| 0| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 0| 1| 7| 3| 4| 3| 3| 3| 9| 3| 1| 0| 6| 5| 6| 3| 3|
| 1| 1| 2| 1| 5| 2| 2| 2| 2| 4| 6| 2| 6| 2| 2| 2| 2| 2| 3| 5| 0| 9| 0| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 1 1 |
Peribronchiolar, Inflammation, | |
Chronic | |
Perivascular, Inflammation, Acute | 3 |
Perivascular, Inflammation, Chronic | |
Perivascular, Inflammation, Chronic | |
Active | 2 |
Pleura, Inflammation, Acute | |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Inflammation, Acute | 2 2 |
Mucosa, Glands, Dilatation | 1 |
Mucosa, Glands, Inflammation, Acute | 1 1 1 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Glomerulosclerosis | 3 |
Hydronephrosis | |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 1 2 1 1 2 1 2 1 1 2|
Metaplasia, Osseous | 1 1 |
Artery, Thrombosis | |
Proximal Convoluted Renal Tubule, | |
Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + M + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Submucosa, Fibrosis | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + M + + + M + + + + + + + + + + + + + + + +| 44 |
Inflammation, Acute | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + M| 47 |
Inflammation, Acute | 3 | 3 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + + + + + + M + + + + + + + + + M + +| 40 |
Mesothelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute | | 1 3.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
Mesothelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Mesothelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + M + +| 46 |
Mesothelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + M M + +| 44 |
Mesothelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + M M + +| 45 |
Hemorrhage | | 1 2.0|
Mesothelium, Hyperplasia | 1 | 1 1.0|
Serosa, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 1.0|
Clear Cell Focus | | 1 1.0|
Congestion | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 2 | 7 2.1|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 1 | 3 1.3|
Necrosis, Coagulative | 1 2 1 1 1 | 12 1.2|
Periportal, Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 2 | 21 1.2|
Serosa, Inflammation, Acute | 3 | 4 2.5|
__________________________________________________________________________|____________|
Mesentery | + + +| 4 |
Fibrosis | | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 3 | 2 3.5|
Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 | 1 4.0|
Atrophy | 3 | 2 2.5|
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 1 1 1 1 | 20 1.1|
Duct, Dilatation | 3 | 1 3.0|
Serosa, Inflammation, Acute | | 1 3.0|
Serosa, Inflammation, Chronic Active | 2 | 3 2.7|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sublingual Gland, Inflammation, | | |
Chronic | 1 | 3 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 | 27 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Acanthosis | 1 2 1| 4 1.5|
Hyperkeratosis | 1 1 2| 4 1.5|
Hyperplasia, Basal Cell | 1| 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Chronic Active, | | |
Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 | 13 1.1|
Inflammation, Chronic Active | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 4 | 1 4.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | 1 2 1 | 6 1.2|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Inflammation, Chronic Active| 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 1.0|
Cyst | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M + + + + + + + + + M + + + M M M + + M| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Pars Distalis, Angiectasis | 2 1 | 2 1.5|
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 2 1 2 2 2 2 3 2 1 2 2 1 | 22 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 | 3 1.0|
Ultimobranchial Cyst | 2 | 1 2.0|
Follicle, Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + M + + + + + + + M + + + + + + + + +| 47 |
Abscess | 4 4 3 4 4 | 10 3.9|
Angiectasis | | 1 2.0|
Cyst | 2 4 3 4 2 4 2 | 16 2.6|
Necrosis, Coagulative | 3 | 1 3.0|
Periovarian Tissue, Cyst | 4 2 | 2 3.0|
Periovarian Tissue, Inflammation, | | |
Chronic | 2 1 | 5 1.8|
Periovarian Tissue, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess | 1| 2 2.5|
Hydrometra | 3 | 1 3.0|
Inflammation, Acute | 2 2 2 2| 9 1.9|
Inflammation, Chronic Active | 2 1 | 4 1.5|
Endometrium, Hyperplasia | 2 3 2 2 2 3 2 2 2 3 3 3 2 3 2 2 1 3 3 2 2 2 2 | 41 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 4 3.5|
Hypoplasia | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myelofibrosis | 1 1 2 1 1 1 1 2 1 2 1 2 1 1 1 1 | 28 1.4|
Myeloid Cell, Hyperplasia | 3| 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Lumbar, Hyperplasia, Plasma Cell | 4 | 2 3.5|
Lumbar, Inflammation, Acute | 2 | 1 2.0|
Mediastinal, Abscess | 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 2 2.0|
Mediastinal, Inflammation, Acute | | 2 2.0|
Mediastinal, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Pancreatic, Hyperplasia, Plasma Cell | 3 | 2 2.5|
Renal, Hyperplasia, Plasma Cell | 4 4 3 | 7 3.0|
Renal, Inflammation, Acute | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M M + + + M M + M M + + + M + + + + + + +| 30 |
Depletion Lymphoid | | 1 3.0|
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M M M + + + + + + + + + + + + + + + + + M| 41 |
Angiectasis | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 1 | 2 1.5|
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 1 3.0|
Depletion Lymphoid | 2 3 3 3| 7 2.9|
Hematopoietic Cell Proliferation | 3 4 3 | 8 2.6|
Hyperplasia, Lymphoid | 1 1 3 1 1 1 | 8 1.4|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M + + + + + + + + + + + + + + + + M + M| 39 |
Depletion Lymphoid | 3 4 | 6 3.5|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + M M M + M + M M M M + + + M + + M M + M| 23 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute, Necrotizing | 4| 1 4.0|
Subcutaneous Tissue, Fibrosis | 1 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 4 |
Thoracic, Inflammation, Acute | 3 | 2 2.5|
Thoracic, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Cerebellum, Inflammation, Chronic | 1 | 1 1.0|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 4 | 2 3.0|
Congestion | | 1 1.0|
Hemorrhage | 2 | 3 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 2 1 | 2 1.5|
Leukocytosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
Peribronchiolar, Inflammation, | | |
Chronic | 2 | 1 2.0|
Perivascular, Inflammation, Acute | | 1 3.0|
Perivascular, Inflammation, Chronic | 1 1 2 | 3 1.3|
Perivascular, Inflammation, Chronic | | |
Active | | 1 2.0|
Pleura, Inflammation, Acute | 4 | 1 4.0|
Pleura, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + M M + + + M + + + + + M + + +| 41 |
Lumen, Inflammation, Acute | | 2 2.0|
Mucosa, Glands, Dilatation | | 1 1.0|
Mucosa, Glands, Inflammation, Acute | 1 1 1 1 1 1 1 1 1 1 1 1 | 19 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2| 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 9| 6| 9| 3| 9| |
| 2| 2| 2| 3| 2| 8| 8| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 8| 8| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 4 | 1 4.0|
Glomerulosclerosis | 3 | 2 3.0|
Hydronephrosis | 2| 1 2.0|
Inflammation, Acute, Necrotizing | 3 | 1 3.0|
Inflammation, Chronic | 2 1 2 1 2 2 2 1 1 1 2 1 2 1 2 2 1 1 2 2 2 | 41 1.4|
Metaplasia, Osseous | | 2 1.0|
Artery, Thrombosis | X| 1 |
Proximal Convoluted Renal Tubule, | | |
Regeneration | 1 1 1 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 | 36 1.1|
Inflammation, Chronic Active | 2 | 1 2.0|
Submucosa, Fibrosis | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + M + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + M + + + + + + + M + + +|
Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Fatty Change | 1 2 1 1 1 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 4 |
Infarct | 4 |
Inflammation, Chronic | 1 1 1 1|
Inflammation, Chronic Active | 1 |
Mineralization | 2 |
Necrosis, Coagulative | 1 4 |
Pigmentation | 2 |
Periportal, Inflammation, Chronic | 1 1 1 1 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 1 |
Inflammation, Chronic | 1 |
Mineralization | 1 |
Necrosis, Coagulative | |
Artery, Thrombosis | |
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectopic Tissue | |
Hyperplasia | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | |
Artery, Mineralization | 1 1 |
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Inflammation, Chronic | 1 |
Parotid Gland, Mineralization | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 2 1 2 1 1 2 2 1 1 2 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + M + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + M + + + + + + + + M + + + + + + + + + +|
Acanthosis | 2|
Hyperkeratosis | 2|
Hyperplasia, Basal Cell | |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Karyomegaly, Chronic Active | |
Ulcer | |
Epithelium, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + M + + + + + + + + M + + + + + + + + + +|
Cyst | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + |
Incisor, Abscess | 3 4 |
Incisor, Dysplasia | 3 2 1 1 2 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 |
Coronary Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia | 1 2 2 1 |
Pigmentation | 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M M + + + M M M + M + + + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 1 1|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 2 1 1 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | 4 2 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic | 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic | |
Seminiferous Tubule, Atrophy | 1 |
Seminiferous Tubule, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Angiectasis | |
Inguinal, Ectasia | |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Plasma Cell | |
Lumbar, Pigmentation | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + + + M + M M M + + + + M M M + M M|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + M + + + + + + + + + + + + + + + M +|
Angiectasis | 2 2 2 2 2 3 2 2 2 1 2 3 3 2 |
Depletion Lymphoid | 3 |
Ectasia | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 4 2 |
Hyperplasia, Lymphoid | 3 4 |
Inflammation, Acute | 3 3 |
Thrombosis | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 4 2 |
Hyperplasia, Lymphoid | 3 |
Necrosis, Coagulative | |
Artery, Endothelium, Hyperplasia | 1 |
__________________________________________________________________________|
Thymus | + + + + M A + M M M + + + M + + + + + + + + + + +|
Cyst | 1 1 1 1 2 X 1|
Depletion Lymphoid | 2 |
Hemorrhage | 1 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 1 4 |
Subcutaneous Tissue, Abscess | 4 |
Subcutaneous Tissue, Fibrosis | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 3 4 4 4 4 3 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Regeneration | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 2 1 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Epithelium, Hyperplasia | |
Mediastinum, Inflammation, Chronic | |
Active | 2 |
Peribronchial, Inflammation, Chronic | |
Perivascular, Inflammation, Chronic | 1 |
Pleura, Inflammation, Acute | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Inflammation, Acute | 2 |
Mucosa, Inflammation, Acute | 2 1 1 1 1 1 1 1 1 2 1 |
Mucosa, Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 1 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | |
Nasopharyngeal Duct, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Eye | I |
Cornea, Inflammation, Chronic Active,| |
Necrotizing | |
Lids, Inflammation, Chronic Active, | |
Necrotizing | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
Cyst | 1 |
Glomerulosclerosis | 1 1 |
Hydronephrosis | |
Inflammation, Chronic | 1 2 1 1 1 2 2 1 1 2 1 1 1 1 1 2 1 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 9| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 9| 3|
| 8| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 0| 9| 7| 7| 7| 7| 7| 7| 1| 2| 7| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Metaplasia, Osseous | |
Papilla, Necrosis, Coagulative | |
Proximal Convoluted Renal Tubule, | |
Atrophy | 2 |
Proximal Convoluted Renal Tubule, | |
Mineralization | |
Proximal Convoluted Renal Tubule, | |
Regeneration | 1 1 1 2 2 2 1 1 1 2 1 1 1 1 2 2 2 1|
Proximal Convoluted Renal Tubule, | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + M + + + + + + + + + + + + +| 45 |
Inflammation, Chronic | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 5 2.2|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 4 1| 4 2.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | 2 | 1 2.0|
Fatty Change | 1 2 1 1 1| 11 1.3|
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | | 1 4.0|
Infarct | | 1 4.0|
Inflammation, Chronic | 1 1 1 1 | 8 1.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Mineralization | | 1 2.0|
Necrosis, Coagulative | 1 3 | 4 2.3|
Pigmentation | | 1 2.0|
Periportal, Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 1 | 16 1.2|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fibrosis | 2 2 1 | 4 1.5|
Inflammation, Chronic | | 1 1.0|
Mineralization | 1 1 | 3 1.0|
Necrosis, Coagulative | 4 4 1 | 3 3.0|
Artery, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 1 1.0|
Ectopic Tissue | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 1 1 1 1 1 | 17 1.0|
Necrosis, Coagulative | 1 | 1 1.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Artery, Mineralization | 1 2 1 | 5 1.2|
Duct, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Inflammation, Chronic | | 1 1.0|
Parotid Gland, Mineralization | 1 1 | 2 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 2 1 1 1 1 2 2 2 2 1 1 1 1 1 1 1 1 1 1 2| 42 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | 1 1 2 | 4 1.5|
Hyperkeratosis | 1 1 2 2 | 5 1.6|
Hyperplasia, Basal Cell | 1 1 2 2 | 4 1.5|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 2 1 1 | 3 1.3|
Karyomegaly, Chronic Active | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
Epithelium, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 1 1 | 2 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 | 12 1.0|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + | 17 |
Incisor, Abscess | 3 4 2 4 3 2 | 8 3.1|
Incisor, Dysplasia | 3 3 | 9 2.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 1 1 1 | 10 1.0|
Coronary Artery, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | | 1 1.0|
Hyperplasia | 2 | 5 1.6|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + M + M M M + M M + + + M M M + M + + M| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Cyst | 2 1 X X 1 1| 7 1.2|
Pars Distalis, Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 | 20 1.1|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 10 |
Abscess | 4 4 4 | 6 3.7|
Inflammation, Chronic | 1 1 | 2 1.0|
Inflammation, Chronic Active | 4 | 2 2.5|
Duct, Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Necrotizing | 4 | 1 4.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 | 36 1.1|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 1 1.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 2 | 22 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 4 | 1 4.0|
Seminiferous Tubule, Atrophy | 4 | 2 2.5|
Seminiferous Tubule, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Angiectasis | 2 | 1 2.0|
Inguinal, Ectasia | 2 | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | 2 3 | 2 2.5|
Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Lumbar, Pigmentation | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + M + M + + M M M M + M M M M + + + + +| 27 |
Depletion Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + M +| 45 |
Angiectasis | 2 1 3 1 2 2 1 1 1 2 2 2 2 2 | 28 1.9|
Depletion Lymphoid | | 1 3.0|
Ectasia | 3 3 | 2 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 2 | 3 2.7|
Hyperplasia, Lymphoid | 1 | 3 2.7|
Inflammation, Acute | | 2 3.0|
Thrombosis | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 3 2 | 7 2.6|
Hyperplasia, Lymphoid | 2 2 2 | 4 2.3|
Necrosis, Coagulative | 2 | 1 2.0|
Artery, Endothelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M M + + M + +| 41 |
Cyst | 1 1 1 1 1 | 12 1.1|
Depletion Lymphoid | 3 2 3 | 4 2.5|
Hemorrhage | 1 1 1| 4 1.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 | 2 1.5|
Inflammation, Acute, Necrotizing | 2 4 | 2 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
Subcutaneous Tissue, Abscess | | 1 4.0|
Subcutaneous Tissue, Fibrosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Joint, Tarsal, Hyperostosis | 4 4 4 4 4 4 4 3 4 4 4 4 4 X 4 4 4 4 4 | 33 3.9|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Abdominal, Regeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 39 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 1 | 5 1.0|
Infiltration Cellular, Histiocyte | 1 | 3 1.3|
Inflammation, Chronic Active | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.0|
Bronchiole, Epithelium, Hyperplasia | 1 | 1 1.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 2.0|
Peribronchial, Inflammation, Chronic | 1 | 1 1.0|
Perivascular, Inflammation, Chronic | 2 | 2 1.5|
Pleura, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Inflammation, Acute | 1 | 2 1.5|
Mucosa, Inflammation, Acute | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 26 1.1|
Mucosa, Inflammation, Chronic Active | 1 | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Acute | 4 | 1 4.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 2 | 1 2.0|
Nasopharyngeal Duct, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cornea, Inflammation, Chronic Active,| | |
Necrotizing | 4 | 1 4.0|
Lids, Inflammation, Chronic Active, | | |
Necrotizing | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 | 1 4.0|
Bacterium | 3 | 1 3.0|
Cyst | | 1 1.0|
Glomerulosclerosis | 1 2 | 4 1.3|
Hydronephrosis | 3 | 1 3.0|
Inflammation, Chronic | 1 2 1 3 1 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.3|
Metaplasia, Osseous | 1 1 | 2 1.0|
Papilla, Necrosis, Coagulative | 3 | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Atrophy | 1 | 2 1.5|
Proximal Convoluted Renal Tubule, | | |
Mineralization | 1 | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Regeneration | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.2|
Proximal Convoluted Renal Tubule, | | |
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | + + + +| 4 |
Calculus Micro Observation Only | X X X X| 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 5| 3| 3| 3| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| |
| 7| 7| 6| 7| 8| 7| 7| 7| 8| 7| 8| 2| 7| 8| 7| 8| 8| 8| 6| 6| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Calculus Micro Observation Only | X X | 3 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 35 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + |
Necrosis | 3 |
Adventitia, Inflammation, Acute | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | X |
Fibrosis | 3 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + M |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Basophilic Focus | 2 |
Degeneration | 1 2 1 1 2 2 1 1 1 1 1|
Eosinophilic Focus | 2 |
Fatty Change | 2 1 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 2 1 1 1 1 1|
Inflammation, Acute | |
Inflammation, Chronic | 1 1 2 1 1 |
Inflammation, Chronic Active | 4 |
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 2 1 4 1 1 1 |
Pigmentation | 1 |
Regeneration | 1 |
Centrilobular, Cytomegaly | 2 2 3 4 2 4 4 3 2 2 1 3 3 3 1 3 2|
Centrilobular, Karyomegaly | 1 2 2 2 1 2 2 1 1 2 1 2 2 2 1 2 1|
Periportal, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 |
Necrosis, Coagulative | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + |
Inflammation, Chronic Active | 4 1 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Salivary Glands | + + M |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Submandibular Gland, Inflammation, | |
Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + |
__________________________________________________________________________|
Pituitary Gland | + + + |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Abscess | 4 4 |
Cyst | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 4 |
Inflammation, Chronic Active, | |
Necrotizing | 4 4 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Atrophy | |
__________________________________________________________________________|
Testes | + + + + |
Inflammation, Chronic Active | |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
Congestion | 2 |
Infarct | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + |
Axillary, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Plasma Cell | |
Pancreatic, Hemorrhage | 4 |
Renal, Hemorrhage | 1 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + M + |
Angiectasis | 2 1 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 3 4 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Thymus | + + M |
Depletion Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M |
__________________________________________________________________________|
Skin | + + + + + + |
Inflammation, Acute, Necrotizing | 4 |
Inflammation, Chronic Active, | |
Necrotizing | 4 |
Epidermis, Inflammation, Acute | 1 |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Hemorrhage | |
Thalamus, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.15 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + |
Congestion | 1 2 |
Hemorrhage | 1 1 |
Fat, Mediastinum, Necrosis, | |
Liquifactive | 2 |
Peribronchiolar, Inflammation, | |
Chronic | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + |
Glands, Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + M + |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 4 3 1 2 |
Inflammation, Chronic | 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Proximal Convoluted Renal Tubule, | |
Degeneration | 3 |
Proximal Convoluted Renal Tubule, | |
Regeneration | 2 3 4 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + |
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 4 |
Necrosis | | 1 3.0|
Adventitia, Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 20 |
Calculus Micro Observation Only | | 1 |
Fibrosis | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 5 |
Epithelium, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 9 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 4.0|
Basophilic Focus | | 1 2.0|
Degeneration | 1 1 2 1 2 2 2 2 1 1 3 | 22 1.5|
Eosinophilic Focus | 2 | 2 2.0|
Fatty Change | 2 1 1 1 1 | 7 1.3|
Hematopoietic Cell Proliferation | 1 1 1| 4 1.3|
Hemorrhage | 1 1 2 1 3 3 3 2 4 | 16 1.9|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | 1 | 6 1.2|
Inflammation, Chronic Active | 1 1 1 1 | 5 1.6|
Mixed Cell Focus | 2 | 2 2.0|
Necrosis, Coagulative | 1 1 2 1 1 | 11 1.5|
Pigmentation | | 1 1.0|
Regeneration | | 1 1.0|
Centrilobular, Cytomegaly | 2 1 2 3 2 2 2 2 2 2 4 3 4 2 3 4 1| 34 2.5|
Centrilobular, Karyomegaly | 1 1 2 2 2 2 2 1 2 2 2 2 3 2 2 3 1| 34 1.7|
Periportal, Inflammation, Chronic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fibrosis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis, Coagulative | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + | 8 |
Inflammation, Chronic Active | | 2 2.5|
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 4 |
Submandibular Gland, Inflammation, | | |
Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 5 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + +| 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + +| 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + +| 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 5 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 14 |
Abscess | 4 4 | 4 4.0|
Cyst | 4 | 1 4.0|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Chronic Active | 2 2 | 4 2.8|
Inflammation, Chronic Active, | | |
Necrotizing | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + | 5 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 6 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + | 7 |
Inflammation, Chronic Active | 4 | 1 4.0|
Seminiferous Tubule, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 5 |
Congestion | | 1 2.0|
Infarct | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 27 |
Axillary, Hyperplasia, Lymphoid | 4| 1 4.0|
Lumbar, Hyperplasia, Lymphoid | 2| 1 2.0|
Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Pancreatic, Hemorrhage | | 1 4.0|
Renal, Hemorrhage | | 1 1.0|
Renal, Hyperplasia, Lymphoid | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + | 20 |
Angiectasis | | 3 1.7|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 2 2 3 2 2 3 3 3 2 3 | 14 2.6|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 20 |
Hematopoietic Cell Proliferation | 2 2 | 5 2.6|
Hyperplasia, Lymphoid | 3 3| 3 3.3|
__________________________________________________________________________|____________|
Thymus | + + | 4 |
Depletion Lymphoid | 3 1 | 4 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + + + +| 11 |
Inflammation, Acute, Necrotizing | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active, | | |
Necrotizing | 4 | 2 4.0|
Epidermis, Inflammation, Acute | | 1 1.0|
Subcutaneous Tissue, Abscess | 4| 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + +| 33 |
Joint, Tarsal, Hyperostosis | 4 4 4 3 4 4 4 2 4 4 4 4 4 4 3| 28 3.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 5 |
Hemorrhage | 2 | 1 2.0|
Thalamus, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 14 |
Congestion | 3 | 3 2.0|
Hemorrhage | 1 1 | 4 1.0|
Fat, Mediastinum, Necrosis, | | |
Liquifactive | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic | 2 | 1 2.0|
Perivascular, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + | 3 |
Glands, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glomerulosclerosis | 2 3 | 6 2.5|
Inflammation, Chronic | 2 2 2 2 2 1 1 1 1 1 1 2 2 1 2 3 1 3 2 2 2 3| 42 1.5|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 5| 0| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 9| |
| 2| 3| 3| 2| 2| 2| 3| 3| 3| 3| 1| 9| 5| 3| 3| 3| 6| 3| 6| 3| 3| 3| 3| 3| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.15 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Proximal Convoluted Renal Tubule, | | |
Degeneration | | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Regeneration | | 3 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 6 |
Inflammation, Chronic | 1 2 | 2 1.5|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + M M + + + + + + + + M + + + + M + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + M + + + + + M + M + M + + + +|
Inflammation, Chronic | 1 1 1 1 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Lymphoid Tissue, Necrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Peyer's Patch, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 1 1 2 2 2 |
Cyst | |
Degeneration | 2 2 2 2 2 2 3 1 2 2 2 2 3 2 2 2 1 2 2 |
Eosinophilic Focus | 2 |
Fatty Change | 2 1 1 2 2 1 1 2 |
Hemorrhage | 2 1 1 1 2 2 2 2 1 1 2 1 2 2 |
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | |
Karyomegaly | |
Mineralization | |
Mixed Cell Focus | 3 |
Necrosis, Coagulative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 |
Centrilobular, Cytomegaly | 1 2 2 3 1 2 2 3 2 2 2 2 2 3 3 2 2 2 2 1 2 2 1|
Centrilobular, Karyomegaly | 1 2 2 3 1 2 2 3 2 2 2 2 2 3 2 2 2 1 2 1 2 2 1|
Periportal, Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
Pigmentation | |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 |
Artery, Mineralization | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Inflammation, Chronic | 1 |
Sublingual Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Hyperkeratosis | 1 2 1 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 2|
Inflammation, Chronic Active, | |
Necrotizing | 1 |
Muscularis, Mineralization | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | 2 1 1 1 |
Pigmentation | |
Muscularis, Mineralization | 1 |
__________________________________________________________________________|
Tooth | + + |
Incisor, Abscess | 3 2 |
Incisor, Bacterium | |
Incisor, Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + + + + M M + + + + M + + M M + + + +|
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Pituitary Gland | M + M + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Follicle, Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + |
Inflammation, Chronic | |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 2 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Preputial Gland | + + + |
Hemorrhage | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 2 1 1 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1|
Seminiferous Tubule, Atrophy | 1 |
Seminiferous Tubule, Giant Cell | |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Bronchial, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Plasma Cell | |
Inguinal, Inflammation, Acute | |
Inguinal, Pigmentation | 1 |
Mediastinal, Angiectasis | |
Mediastinal, Depletion Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 2 |
Pancreatic, Angiectasis | 2 |
Pancreatic, Depletion Lymphoid | 3 |
Pancreatic, Ectasia | 3 |
Pancreatic, Hematopoietic Cell | |
Proliferation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M + + M + + M + M M M + M + M M M|
Hyperplasia, Lymphoid | 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + M + + + + + +|
Angiectasis | 2 3 2 2 2 2 1 2 2 2 1 2 1|
Depletion Lymphoid | |
Fibrosis | 3 |
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | 2 1 2 1 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | M + + + M + + M M M + + + + + M + + M + + + + M +|
Cyst | 1 1 1 1 |
Depletion Lymphoid | 1 3 |
Hemorrhage | 1 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + + + + + + + + + + + + +|
Acanthosis | |
Cyst | |
Hemorrhage | 3|
Inflammation, Acute, Hemorrhagic | |
Inflammation, Acute | 1 1 1 2 |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Granuloma | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Tumor | X |
Hemorrhage | 1 2 1 |
Infiltration Cellular, Histiocyte | 2 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + M + + + + + + + + + + + + M + + + + +|
Lumen, Inflammation, Acute | 2 |
Mucosa, Inflammation, Acute | 1 1 1 1 1 1 1 1 1 1 1|
Mucosa, Inflammation, Chronic | 2 |
Mucosa, Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 2 2 1 |
Infarct | 2 |
Inflammation, Chronic | 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 2|
Inflammation, Chronic Active | 2 |
Medulla, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 9| 3| 3| 0| 0| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3|
| 8| 0| 0| 0| 1| 9| 1| 1| 0| 3| 1| 1| 1| 0| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Proximal Convoluted Renal Tubule, | |
Regeneration | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Ureter | + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Urethra | + + + + |
Calculus Micro Observation Only | 1 X 3 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | 2 2 X |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M M + + M + + + + + + + + M M + + + + M +| 39 |
Inflammation, Chronic | 1 | 6 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + M + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Lymphoid Tissue, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 2.0|
Peyer's Patch, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 | 2 2.0|
Clear Cell Focus | | 5 1.6|
Cyst | 3 | 1 3.0|
Degeneration | 2 2 2 2 1 2 2 1 2 2 1 2 2 2 2 2 2 1 2| 38 1.9|
Eosinophilic Focus | 1 | 2 1.5|
Fatty Change | 1 2 3 2 2 1 2 1 2 2 1 2| 20 1.7|
Hemorrhage | 2 2 2 1 2 1 2 1 2 2 1 1 2| 27 1.6|
Inflammation, Chronic | 2 1 2 | 8 1.3|
Inflammation, Chronic Active | 1 2 1 2 1 1 1 1| 8 1.3|
Karyomegaly | 2| 1 2.0|
Mineralization | 1 | 1 1.0|
Mixed Cell Focus | X | 2 3.0|
Necrosis, Coagulative | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 26 1.0|
Centrilobular, Cytomegaly | 2 2 3 3 2 2 2 2 2 2 1 2 2 1 2 2 2 1 2 2 2 2| 45 2.0|
Centrilobular, Karyomegaly | 1 2 2 2 2 2 2 2 2 2 1 2 2 1 2 2 2 1 2 2 2 | 44 1.9|
Periportal, Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 1 1.0|
Inflammation, Chronic | 1 1 | 11 1.0|
Inflammation, Chronic Active | | 1 1.0|
Artery, Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parotid Gland, Inflammation, Chronic | | 1 1.0|
Sublingual Gland, Inflammation, | | |
Chronic | 1 | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 40 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 2 2 | 4 1.5|
Hyperkeratosis | 2 1 2 | 6 1.5|
Hyperplasia, Basal Cell | 2 1 | 3 1.7|
Inflammation, Acute, Necrotizing | 2 | 1 2.0|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Chronic Active | 1 | 4 1.3|
Inflammation, Chronic Active, | | |
Necrotizing | | 1 1.0|
Muscularis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 1 1| 8 1.0|
Inflammation, Chronic Active | 1 | 5 1.2|
Pigmentation | 1 | 1 1.0|
Muscularis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + | 5 |
Incisor, Abscess | 3 4 | 4 3.0|
Incisor, Bacterium | 3 | 1 3.0|
Incisor, Dysplasia | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Fibrosis | | 1 1.0|
Inflammation, Chronic | | 3 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + M + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + M + + + + + + + + + M +| 48 |
Hyperplasia | | 2 2.0|
Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + M +| 48 |
Hyperplasia | 3 1 1 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + M M + + + + + + M + M + M M + + +| 34 |
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + M + + + + + + + + +| 45 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 2 1 | 6 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 1.0|
Follicle, Cyst | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + | 11 |
Inflammation, Chronic | 2 | 1 2.0|
Perivascular, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 2 1 2 1 1 1 2| 20 1.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 8 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 | 33 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic | 1 1 1 | 8 1.1|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 2 1.0|
Seminiferous Tubule, Atrophy | 1 1 | 3 1.0|
Seminiferous Tubule, Giant Cell | 1 | 1 1.0|
Seminiferous Tubule, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Inguinal, Inflammation, Acute | 1 | 1 1.0|
Inguinal, Pigmentation | 1 | 2 1.0|
Mediastinal, Angiectasis | 2 | 1 2.0|
Mediastinal, Depletion Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Pigmentation | | 1 2.0|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Depletion Lymphoid | | 1 3.0|
Pancreatic, Ectasia | | 1 3.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M M + + M + + + + M + + M + M M + + + + M + +| 23 |
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
Angiectasis | 2 1 1 1 1 1 1 2 2 2 2 1 2 2 1 3 1| 30 1.7|
Depletion Lymphoid | 1 3 | 2 2.0|
Fibrosis | | 1 3.0|
Hemorrhage | 1 | 3 1.3|
Hyperplasia, Lymphoid | 2 | 5 1.6|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | 3 2 2 | 5 2.2|
Hematopoietic Cell Proliferation | 4 2 3 | 7 2.4|
Hyperplasia, Lymphoid | 1 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Thymus | M + M + M + M M + + + + + + + M + + + M + M + + +| 34 |
Cyst | 1 1 1 | 7 1.0|
Depletion Lymphoid | 4 2 | 4 2.5|
Hemorrhage | | 2 1.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 | 1 2.0|
Cyst | 2 | 1 2.0|
Hemorrhage | 4 4 | 3 3.7|
Inflammation, Acute, Hemorrhagic | 2 | 1 2.0|
Inflammation, Acute | 1 4 | 6 1.7|
Inflammation, Acute, Necrotizing | 4 4 4 4| 4 4.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Subcutaneous Tissue, Fibrosis | 3 | 1 3.0|
Subcutaneous Tissue, Granuloma | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Joint, Tarsal, Hyperostosis | 4 4 3 4 4 4 4 4 2 4 4 4 4 4 4 4 4 3| 35 3.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 | 40 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Tumor | | 1 |
Hemorrhage | 1 1 | 5 1.2|
Infiltration Cellular, Histiocyte | 2 1 1 | 5 1.4|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 2 1 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05063-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 08:17:42
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| |
DAY ON TEST | 3| 3| 1| 1| 1| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 0| 6| 3| 3| |
| 1| 1| 8| 6| 7| 1| 7| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 2| 0| 1| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.3 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 | 3 1.3|
Perivascular, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
Lumen, Inflammation, Acute | 2 | 2 2.0|
Mucosa, Inflammation, Acute | 1 1 1 1 1 2 1 | 18 1.1|
Mucosa, Inflammation, Chronic | | 1 2.0|
Mucosa, Inflammation, Chronic Active | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 2 | 3 2.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glomerulosclerosis | 2 2 1 | 6 1.7|
Infarct | | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 2 2 1 1 1 1 2 1 1 2 1 2 2 1 2 1 1 2| 47 1.3|
Inflammation, Chronic Active | | 1 2.0|
Medulla, Mineralization | 2 | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Regeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 36 1.1|
__________________________________________________________________________|____________|
Ureter | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | + + + | 7 |
Calculus Micro Observation Only | X X X | 6 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + M +| 48 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 3 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------