TDMS Study 05063-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05063 PHENYLBUTAZONE TIME: 21:30:28
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56531
CONT: N01ES1803301 CAS: 50-33-9
PATHOLOGIST: R. FLEISCHMAN
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05063 PHENYLBUTAZONE TIME: 21:30:28
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56531
CONT: N01ES1803301 CAS: 50-33-9
PATHOLOGIST: R. FLEISCHMAN
PHENYLBUTAZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 440 558 586 593 606 627 639 661 666 697 |
| 698 705 712 712 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.15G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 2 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 612 627 633 647 660 697 698 702 |
| CENSORED DEATHS |
| 6 6 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3 G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 416 417 500 534 598 599 618 641 661 697 |
| 697 700 703 712 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PHENYLBUTAZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 92.0 84.0 72.0 |
| | |
| | |
|0.15G/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 89.6 83.3 |
| | |
| | |
|0.3 G/KG | 100.0 100.0 100.0 100.0 96.0 96.0 92.0 88.0 82.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.15G/KG 0.3 G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 83.3% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.254N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 635.7 659.5 606.6 |
|NATURAL DEATHS (C) | (20.3) (12.6) (27.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 703.6 689.8 695.5 |
|(STANDARD ERROR) | ( 8.2) (20.4) (10.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PHENYLBUTAZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 500 568 572 591 596 599 604 610 613 617 |
| 631 633 641 652 659 663 669 670 685 688 |
| 693 702 710 715 718 726 726 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.15G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 31 202 244 245 431 445 476 510 557 564 |
| 569 579 606 612 613 624 646 647 692 705 |
| 712 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3 G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 1 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 59 60 60 376 469 492 492 494 513 568 |
| 605 638 646 698 702 708 714 |
| CENSORED DEATHS |
| 5 |
| |
==================================================================================
PHENYLBUTAZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 86.0 68.0 44.0 |
| | |
| | |
|0.15G/KG | 98.0 98.0 92.0 92.0 92.0 86.0 84.0 76.0 64.0 58.0 |
| | |
| | |
|0.3 G/KG | 93.9 93.9 93.9 93.9 91.8 89.8 81.6 77.6 73.5 65.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.15G/KG 0.3 G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.0% 58.0% 65.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.133N P=0.539N P=0.132N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 649.3 510.0 487.9 |
|NATURAL DEATHS (C) | (10.9) (40.3) (54.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 685.2 638.2 633.8 |
|(STANDARD ERROR) | ( 8.4) (22.8) (27.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PHENYLBUTAZONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
0.15G/KG = 2
0.3 G/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
|
| 1 1 2 2
| 3 3 1 1 22
P 95 +
E | 3 3 1 1 2 2
R | 3 131
C | 2 2
E 90 + 1 1 2 2
N |
T | 3 31 1
| 3 1 1
S 85 + 22
U | 3 11 2 2
R | 31 1
V |
I 80 +
V |
A | 11
L | 311
75 +
| 33
| 1 1
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
PHENYLBUTAZONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
0.15G/KG = 2
0.3 G/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 2 1 1
| 3 2 2 3 1 1
| 2 3 2 3 11
P 90 + 2 2 3 3
E | 2 2 11
R | 2 2 2 11
C | 3 3 223 11
E 80 + 22 3 1 1
N | 22 3 3
T | 2 22 1131
| 31 1 33
S 70 + 2 2 33
U | 2 2 11
R | 2 1 12 3 3
V | 11 2
I 60 + 22
V | 1 12 2
A | 111
L |
50 + 11
|
| 1 1
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.