TDMS Study 05063-01 Pathology Tables
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
Facility: TSI Mason Research
Chemical CAS #: 50-33-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|
| 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + M + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1 1 1 2 2 1 1 2 1 1 2 3 1 2 1 2 1 1 |
Clear Cell Focus | 2 1 1 1 |
Fatty Change | 2 1 2 2 2 2 1 2 1 2 2|
Hemorrhage | 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | 3 2 |
Inflammation, Chronic Active | 1 2 1 1 1 2 1 1 1 1 2 |
Mixed Cell Focus | 1 2 |
Necrosis, Coagulative | 1 1 |
Pigmentation | 1 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Kupffer Cell, Hyperplasia, Focal | 1 |
Periportal, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 2 |
Inflammation, Chronic Active | 4 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 1 1 1 |
Fibrosis, Focal | 1 |
Hyperplasia | 1 |
Inflammation, Chronic | 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|
| 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Basal Cell | 2 |
Inflammation, Granulomatous | |
Ulcer | |
Ulcer, Multiple | |
Submucosa, Foreign Body | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 2 2 2 2 1 1 1 1 1 1 1 1 1 |
Atrium, Embolus | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 1 1 2 2 1 2 2 1 1 2 2 |
Atrophy | 4|
Autolysis | 3 |
Congestion | |
Degeneration | 3|
Hyperplasia | 1 1 |
Mineralization | 1 |
Necrosis, Coagulative | |
Pigmentation | 2|
Vacuolization Cytoplasmic | 1 2 1 1 4 2 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M M + + M + + + + M + + M + M + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Angiectasis | 2 4 4 2 3 3 4 2 4 3 2 2 4 4 1 1 3|
Pars Distalis, Cyst | 2 2 2 3 4 2 1 1 2 1 1 1 |
Pars Distalis, Hyperplasia | 2 1 3 1 1 1 2 |
Pars Distalis, Pigmentation | 1 2 1 2 |
Pars Intermedia, Angiectasis | 4 |
Pars Intermedia, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|
| 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Nervosa, Angiectasis | 3 2 |
Pars Nervosa, Cyst | 2 |
Pars Nervosa, Pigmentation | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M + + + + + + + + M + + + + + + + + M M M M + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 2 1 3 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 |
Mineralization | |
Corpus Luteum, Cyst | |
Periovarian Tissue, Cyst | 1 3 1 |
__________________________________________________________________________|
Oviduct | |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 3 2 3|
Inflammation, Acute | 1|
Thrombosis | 3 |
Endometrium, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + M + + + + + + + + + + + + + + + +|
Myelofibrosis | 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 1 |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Pigmentation | 1 1 2 2 |
Pancreatic, Depletion Lymphoid | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Pigmentation | 2 |
Renal, Angiectasis | |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + M + + + + + + + + + + + + + +|
Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|
| 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | 2 1 1 1 |
Hemorrhage | 1 3 1 3 |
Hyperplasia | |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Depletion Lymphoid | 4 4 2 4 2 4 3 3|
Hematopoietic Cell Proliferation | |
Pigmentation | 3 |
Capsule, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Thymus | + + + + + M + M + M + + M + + + + + + + + + + + +|
Depletion Lymphoid | 3 2 3 2 3 3 2 3 2 2 2 3|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Galactocele | 4 2 4 2 |
Hyperplasia | 2 3 2 2 3 3 2 1 1 1 2 1 2 2 1 2 2 2 3 2 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hydrocephalus | 2 |
Cerebellum, Infarct | |
Medulla, Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 1 1 2|
Inflammation, Acute, Necrotizing | 2 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|
| 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 1 2|
Artery, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 3 |
Inflammation, Chronic Active | 1 1 1 |
Inflammation, Chronic Active, | |
Necrotizing | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | I I |
Cataract | |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2|
Pigmentation | |
Collecting Tubule, Mineralization | 1 1 |
Distal Convoluted Renal Tubule, | |
Mineralization | |
Pelvis, Dilatation | |
Pelvis, Epithelium, Hyperplasia | |
Pelvis, Epithelium, Mineralization | 1 1 1 1 |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | |
Proximal Convoluted Renal Tubule, | |
Mineralization | |
Proximal Convoluted Renal Tubule, | |
Pigmentation | 2 2 2 2|
Renal Tubule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 5|
| 5| 8| 5| 8| 8| 8| 8| 1| 1| 4| 5| 7| 7| 6| 6| 7| 8| 8| 8| 3| 6| 6| 8| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3| |
| 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + M + + + + + M + + M + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 1 1 1 1 2 1 2 | 9 1.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | 2 X 1 2 2 2 1 1 1 1 2 3 1 1 1| 35 1.4|
Clear Cell Focus | | 4 1.3|
Fatty Change | 3 2 2 3 3 2 2 4 2 | 20 2.1|
Hemorrhage | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia | | 2 2.5|
Inflammation, Chronic Active | 2 1 1 2 1 1 | 17 1.3|
Mixed Cell Focus | | 2 1.5|
Necrosis, Coagulative | 1 1 2 1 | 6 1.2|
Pigmentation | | 1 1.0|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 1 1 2 1 1 1 1 1 1 2 1 1 1| 28 1.1|
Kupffer Cell, Hyperplasia, Focal | | 1 1.0|
Periportal, Fibrosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 | 11 1.1|
Fibrosis, Focal | | 1 1.0|
Hyperplasia | | 1 1.0|
Inflammation, Chronic | 1 1 1 1 1 1 1| 12 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3| |
| 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 2 2 | 4 2.0|
Hyperkeratosis | 2 2 | 3 2.0|
Hyperplasia, Basal Cell | 2 2 2 | 4 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
Ulcer, Multiple | 2 | 1 2.0|
Submucosa, Foreign Body | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 2 | 2 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
Aorta, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 2 1 1 1 1 2 1 1 2 1 1 1 2 1| 35 1.3|
Atrium, Embolus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 2 1 1 1 2 2 2 1 2 1 1 1 1| 30 1.5|
Atrophy | | 1 4.0|
Autolysis | | 1 3.0|
Congestion | 2 | 1 2.0|
Degeneration | | 1 3.0|
Hyperplasia | 1 2 1 2 2| 7 1.4|
Mineralization | | 1 1.0|
Necrosis, Coagulative | 1 | 1 1.0|
Pigmentation | | 1 2.0|
Vacuolization Cytoplasmic | 1 3 1 1 1 1 1 2 2 3 1| 24 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | | 1 3.0|
Hyperplasia | 1 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3| |
| 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis, Focal | 1 | 1 1.0|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + M + + + + A M + + + + + M + M M + M M +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 4 1 2 2 1 3 2 2 2 2 3 2 2 4 1 2 2 3 4| 36 2.6|
Pars Distalis, Cyst | 1 2 2 2 1 1 1 3 2 4 1 | 23 1.8|
Pars Distalis, Hyperplasia | 1 1 2 | 10 1.5|
Pars Distalis, Pigmentation | 1 1 1 2 1 1 1 1| 12 1.3|
Pars Intermedia, Angiectasis | 3 | 2 3.5|
Pars Intermedia, Pigmentation | 1 1 | 2 1.0|
Pars Nervosa, Angiectasis | | 2 2.5|
Pars Nervosa, Cyst | | 1 2.0|
Pars Nervosa, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
C-Cell, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1| 24 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + M M + M + M + + + + + + M + + + + + +| 36 |
Inflammation, Chronic | 1 1 2 1 1 1 1 | 8 1.1|
Inflammation, Chronic Active | 2 1 1 2 1| 12 1.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 | 1 1.0|
Cyst | 2 2 | 3 2.0|
Mineralization | 1 1| 2 1.0|
Corpus Luteum, Cyst | 2 | 1 2.0|
Periovarian Tissue, Cyst | 2 | 4 1.8|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 6 2.3|
Inflammation, Acute | 1 | 2 1.0|
Thrombosis | | 1 3.0|
Endometrium, Hyperplasia | 2 3 1 2 1 2 | 9 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3| |
| 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hemorrhage | 3 2 | 3 2.0|
Mediastinal, Hyperplasia | 2 | 2 2.5|
Mediastinal, Pigmentation | | 4 1.5|
Pancreatic, Depletion Lymphoid | 2 | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Pancreatic, Pigmentation | 1 2 | 3 1.7|
Renal, Angiectasis | 3 | 1 3.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + M M + + M M M +| 42 |
Angiectasis | | 1 3.0|
Ectasia | | 4 1.3|
Hemorrhage | 3 1 | 6 2.0|
Hyperplasia | 2 | 1 2.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1| 35 1.1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 1.5|
Depletion Lymphoid | 4 3 2 2 2 3 | 14 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Pigmentation | 2 2 2 | 4 2.3|
Capsule, Fibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M M + + + + + + + + + + + + M + + M| 42 |
Depletion Lymphoid | 3 4 2 3 3 3 4 2 3 4 2 3 3 4 4 4 | 28 2.9|
Hemorrhage | 2 2 | 2 2.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + M + + + + + + + + + + M + +| 46 |
Galactocele | | 4 3.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 1 2 2 1 3 2 2 2 2 2 4| 41 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3| |
| 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 2 3.0|
Hydrocephalus | | 1 2.0|
Cerebellum, Infarct | 1 4 | 2 2.5|
Medulla, Infarct | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Hemorrhage | 1 1 | 4 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 9 1.1|
Inflammation, Acute, Necrotizing | | 1 2.0|
Inflammation, Chronic | 1 1 1 | 11 1.0|
Inflammation, Chronic Active | 1 1 1 2 1 2 1| 9 1.2|
Alveolar Epithelium, Hyperplasia | 1 1 1 2 1 | 9 1.3|
Artery, Hyperplasia | 2 | 1 2.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 18 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Acute | 1 1 | 4 1.5|
Inflammation, Chronic Active | 2 2 | 5 1.4|
Inflammation, Chronic Active, | | |
Necrotizing | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 3 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 2| 4| 7| |
DAY ON TEST | 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 0| 8| 3| 1| 9| 1| 3| 3| 1| 2| 3| |
| 8| 0| 5| 8| 7| 7| 7| 8| 7| 8| 5| 3| 8| 8| 4| 5| 8| 4| 0| 9| 7| 8| 1| 1| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Sclera, Metaplasia, Osseous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Cyst | 4 | 1 4.0|
Nephropathy | 2 2 2 1 1 2 2 2 1 1 2 3 2 2 3 1 2 1 2| 38 1.5|
Pigmentation | 2 2 | 2 2.0|
Collecting Tubule, Mineralization | 1 | 3 1.0|
Distal Convoluted Renal Tubule, | | |
Mineralization | 1 | 1 1.0|
Pelvis, Dilatation | 4 | 1 4.0|
Pelvis, Epithelium, Hyperplasia | 1 2 1 1 1 3 2 | 7 1.6|
Pelvis, Epithelium, Mineralization | 1 1 1 1 1 1 1 1 1 | 13 1.0|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 1 1| 2 1.0|
Proximal Convoluted Renal Tubule, | | |
Mineralization | 1 | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | | 4 2.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | X | 1 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Metaplasia, Squamous | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 3| 8| 3| 8| 3|
| 4| 5| 4| 8| 8| 6| 5| 5| 4| 4| 6| 5| 4| 8| 8| 5| 4| 6| 5| 5| 5| 2| 5| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Small | + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + |
Angiectasis | 3 1 |
Basophilic Focus | 1 1 1 1 X 1 |
Clear Cell Focus | 2 |
Eosinophilic Focus | 3 2 2 3 |
Fatty Change | 1 2 2 1 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Chronic Active | 1 1 1 2 1 1 2 1 |
Necrosis, Coagulative | 1 1 3 |
Bile Duct, Hyperplasia | 1 2 2 1 1 |
Periportal, Fibrosis | 1 |
Serosa, Inflammation, Chronic, Focal | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 2 3 |
Hemorrhage | 2 |
Mineralization | 1 |
Necrosis, Coagulative | 3 3 |
__________________________________________________________________________|
Pancreas | + + + |
Atrophy | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | |
Ulcer | 2 |
Muscularis, Mineralization | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Fibrosis | 3 |
Muscularis, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 3| 8| 3| 8| 3|
| 4| 5| 4| 8| 8| 6| 5| 5| 4| 4| 6| 5| 4| 8| 8| 5| 4| 6| 5| 5| 5| 2| 5| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 2 1 2 1 1 1 1 1 2 1 1 1|
Atrophy | 4 |
Autolysis | 3 |
Hyperplasia | 1 2 2 1 1 1 1|
Necrosis, Coagulative | 1 4 |
Vacuolization Cytoplasmic | 1 2 1 2 1 1 1 2 1 3 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | 3 |
Hyperplasia | 1 1 1 1 1 |
Necrosis, Coagulative | 3 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 2 4 3 3 3 3 2 3 4 3 3|
Pars Distalis, Cyst | 2 1 1 1 2 1 3 1 4 2 3 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 1 2 |
Pars Distalis, Pigmentation | 2 |
Pars Intermedia, Angiectasis | 3 2 |
Pars Intermedia, Cyst | 1 2 1 3 |
Pars Nervosa, Angiectasis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Inflammation, Chronic Active, | |
Necrotizing | 4 3 |
__________________________________________________________________________|
Ovary | + + + + + + |
Atrophy | 3 |
Cyst | X |
Periovarian Tissue, Cyst | X 4 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 3| 8| 3| 8| 3|
| 4| 5| 4| 8| 8| 6| 5| 5| 4| 4| 6| 5| 4| 8| 8| 5| 4| 6| 5| 5| 5| 2| 5| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + |
Hydrometra | 2 |
Endometrium, Hyperplasia | 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + M |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Depletion Lymphoid | |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 3 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + |
Hemorrhage | 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Depletion Lymphoid | |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Depletion Lymphoid | 3 2 2 3 2 2 |
Pigmentation | 2 3 |
__________________________________________________________________________|
Thymus | + + |
Congestion | |
Depletion Lymphoid | 3 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M + + + |
Galactocele | |
Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 3| 3| 3| 3| 3| 8| 3| 8| 3|
| 4| 5| 4| 8| 8| 6| 5| 5| 4| 4| 6| 5| 4| 8| 8| 5| 4| 6| 5| 5| 5| 2| 5| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mineralization | 1 1 |
__________________________________________________________________________|
Nose | + + |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Nasolacrimal Duct, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation, Acute, Necrotizing | 3 |
Nephropathy | 2 1 1 2 2 3 3 2 2 3 2 3 1 2 2 3 2 2 2 3 3 2 2 1|
Collecting Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2|
Papilla, Mineralization | |
Papilla, Necrosis | 1 2 1 1 1 1 1 1 2 |
Pelvis, Epithelium, Hyperplasia | 1 1 1 1 1 2 2 2 2 1|
Pelvis, Epithelium, Mineralization | 2 1 1 2|
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 2 2 1|
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 4 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3| |
| 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + | 5 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M | 6 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 27 |
Angiectasis | | 2 2.0|
Basophilic Focus | 2 2 2 1 1 1 2 1 | 14 1.3|
Clear Cell Focus | | 1 2.0|
Eosinophilic Focus | 1 | 5 2.2|
Fatty Change | 3 1 1 1 1 2 2 | 11 1.5|
Hepatodiaphragmatic Nodule | X | 3 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 1 3 1 | 11 1.4|
Necrosis, Coagulative | | 3 1.7|
Bile Duct, Hyperplasia | 2 1 1 | 8 1.4|
Periportal, Fibrosis | | 1 1.0|
Serosa, Inflammation, Chronic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fibrosis | 3 | 3 2.7|
Hemorrhage | | 1 2.0|
Mineralization | 3 | 2 2.0|
Necrosis, Coagulative | 4 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 9 |
Atrophy | 2 1 | 3 1.7|
Inflammation, Chronic | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Basal Cell | 1 | 1 1.0|
Ulcer | | 1 2.0|
Muscularis, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3| |
| 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | | 1 3.0|
Muscularis, Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 7 |
Cardiomyopathy | 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 1 2 2 2 1 2 | 26 1.3|
Atrophy | | 1 4.0|
Autolysis | | 1 3.0|
Hyperplasia | 1 2 2 2 2 | 12 1.5|
Necrosis, Coagulative | | 2 2.5|
Vacuolization Cytoplasmic | 2 1 1 1 1 1 2 1 1 1 1 1 1| 27 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1| 1 1.0|
Autolysis | | 1 3.0|
Hyperplasia | 2 | 6 1.2|
Necrosis, Coagulative | | 2 3.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + + + + + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 4 4 4 4 3| 19 3.1|
Pars Distalis, Cyst | 2 3 2 1 2 1 1 2 2 2 1 X 1 1| 26 1.8|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 3 2 3 | 6 2.3|
Pars Distalis, Pigmentation | 1 | 2 1.5|
Pars Intermedia, Angiectasis | | 2 2.5|
Pars Intermedia, Cyst | | 4 1.8|
Pars Nervosa, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 2 2 1 1 1 1 1 1| 26 1.2|
Follicular Cell, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3| |
| 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + M + + + | 11 |
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Inflammation, Chronic Active, | | |
Necrotizing | 4 4 | 4 3.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 14 |
Atrophy | | 1 3.0|
Cyst | 2 | 2 2.0|
Periovarian Tissue, Cyst | 4 2 | 4 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 17 |
Hydrometra | | 1 2.0|
Endometrium, Hyperplasia | 2 | 3 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 15 |
Mediastinal, Depletion Lymphoid | 4 | 1 4.0|
Mediastinal, Ectasia | 2 | 1 2.0|
Mediastinal, Hemorrhage | 3 3 | 3 3.0|
Renal, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M | 5 |
Hemorrhage | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 13 |
Depletion Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 5 1.0|
Pigmentation | 1 1 2 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 1.0|
Depletion Lymphoid | 3 3 4 4 4 4 2 2| 14 2.9|
Pigmentation | 3 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 8 |
Congestion | 3 | 1 3.0|
Depletion Lymphoid | 4 3 3 2 | 6 3.0|
Hemorrhage | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + + + + + M + + + +| 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3| |
| 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | X | 1 |
Hyperplasia | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + +| 12 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 7 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 20 |
Congestion | 3 3 | 3 2.7|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 3 1 1 1 1 | 6 1.3|
Inflammation, Chronic Active | 2 1 | 4 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Artery, Mineralization | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + | 6 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 1 2.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 2.0|
Inflammation, Acute, Necrotizing | | 1 3.0|
Nephropathy | 2 2 3 3 2 1 1 3 2 3 1 3 1 2 3 2 3 1 3 1 3 1| 46 2.1|
Collecting Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 31 1.1|
Papilla, Mineralization | 3 | 1 3.0|
Papilla, Necrosis | 2 1 1 2 1 1 1 1 1 | 18 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 5| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 7| 1| 5| 3| 3| 3| 3| 3| 0| 3| 7| 3| 3| 3| 3| 3| 3| 9| 5| 8| 3| 3| 3| 3| |
| 5| 8| 2| 6| 5| 6| 5| 5| 5| 3| 5| 7| 5| 5| 5| 5| 5| 4| 8| 4| 9| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Epithelium, Hyperplasia | 2 1 3 1 1 2 2 2 1 1 | 20 1.5|
Pelvis, Epithelium, Mineralization | 1 1 1 1 1 1 1 | 11 1.2|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 1 | 4 1.5|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | 2 | 1 2.0|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Necrotizing | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|
| 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + M + + M M M + + M M M M M M M M M + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + + + + + + +|
Angiectasis | |
Parasite Metazoan | 1 1 |
Mucosa, Fibrosis | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +|
Metaplasia, Focal, Squamous | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Chronic | 4 |
Inflammation, Chronic Active, | |
Necrotizing | |
Epithelium, Hyperplasia | |
Muscularis, Inflammation, Acute | |
Muscularis, Mineralization | |
Serosa, Fibrosis | 1 |
Serosa, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Nodule, Depletion Cellular | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Chronic Active, | |
Necrotizing | 4 |
Ulcer | 4 |
Muscularis, Inflammation, Acute | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Clear Cell Focus | 1 1 2 |
Eosinophilic Focus | 1 1 |
Fatty Change | 2 1 1 1 2 1 1 2 2 |
Focal Cellular Change | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 2 4 |
Inflammation, Chronic Active | 1 2 1 1 2 |
Necrosis, Coagulative | 2 1 |
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Centrilobular, Cytomegaly | 3 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|
| 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Kupffer Cell, Hyperplasia, Focal | |
Periportal, Fibrosis | |
Serosa, Inflammation, Suppurative | 2 |
Subserosa, Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fibrosis | 2 2 |
Hemorrhage | 1 |
Inflammation, Chronic Active | 2 |
Mineralization | 1 2 1 |
Necrosis, Coagulative | 2 2 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 1 1 |
Inflammation, Chronic | 1 1 3 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 2 3 |
Edema | 3 |
Erosion | |
Hyperkeratosis | 2 2 2 2 3 3 |
Hyperplasia, Basal Cell | 2 2 2 2 2 3 |
Inflammation, Chronic Active | 3 |
Ulcer | 2 2 4 4 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Edema | 2 |
Erosion | 2 |
Inflammation, Chronic Active | 1 2 2 1|
Mineralization | 3 |
Ulcer | 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 2 2 1 2 2 2 2 2 2 2 3 2 2 1 2 1 1 1 1 1|
Mineralization | 2 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 1 1 1 1 1|
Degeneration, Fatty | |
Hyperplasia | 1 1 1 2 1|
Necrosis, Coagulative | 4 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|
| 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 1 1 1 1 1 1|
Thrombosis | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + M + M M M M M M M M M + + + M M + + M M M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 1 4 2 2 4 2 2 3 4 2 1 2 3 3 1 4 4 |
Pars Distalis, Cyst | 2 1 1 1 2 1 1 2 1 1 1|
Pars Distalis, Hyperplasia | 1 1 2 1 1 1 2 |
Pars Distalis, Pigmentation | 1 1 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M M + + + + M + M|
Inflammation, Acute | 4 |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 2 1 2 1 1 2 3 2 1 3 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 3 |
Hyperplasia | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 1 2 1 2 2 1 |
Inflammation, Acute | |
Endometrium, Hyperplasia | 2 2 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + M + + + + + + + + I + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + + + + + + + +|
Mediastinal, Depletion Lymphoid | 3 |
Mediastinal, Hemorrhage | 2 1 1 1 1 3 |
Mediastinal, Inflammation, Chronic | |
Active | 2 |
Renal, Ectasia | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 1 |
Renal, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|
| 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + M + + M + + + + M M + M + + + M + M + M|
Depletion Lymphoid | |
Ectasia | |
Hemorrhage | 2 1 4 3 2 |
Hyperplasia | 2 1 2 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M M + + + + + + + +|
Depletion Lymphoid | 2 2 |
Ectasia | 2 2 4 2 |
Hemorrhage | 1 1 |
Hyperplasia | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 2 2 2 1 4 1 3 3 |
Hematopoietic Cell Proliferation | 2 2 2 |
Pigmentation | |
Subcapsular, Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + M M + + + + + M + + + + + + + M|
Congestion | 3 |
Cyst | 2 |
Depletion Lymphoid | 2 3 3 2 4 2 3 2 2 3 4 2 2 2 3 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + M + + + + + + + + + + + + + M + + +|
Degeneration | 2 |
Galactocele | 2 |
Hyperplasia | 2 2 1 4 2 2 2 2 2 2 2 2 2 2 2 2 4 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|
| 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | |
Foreign Body | 3 |
Granuloma | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Acute | |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | 2 1 2 |
Thrombosis, Multiple | |
Alveolar Epithelium, Hyperplasia | 2 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Bronchus, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Acute, Necrotizing | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Nasolacrimal Duct, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | I I I |
__________________________________________________________________________|
Lacrimal Gland | + |
Hyperplasia | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 4 4 4 |
Cyst | 1 1 3 1 1 X 2 2 1 2|
Inflammation, Acute, Necrotizing | 4 4 |
Inflammation, Chronic Active | |
Inflammation, Chronic Active, | |
Necrotizing | 4 4 |
Nephropathy | 4 3 4 4 4 4 4 3 4 2 3 3 4 4 4 4 3 2 3 4 4 4 4|
Pigmentation | |
Collecting Tubule, Mineralization | 3 2 2 2 2 1 2 1 3 2 2 3 2 3 3 4 2 2 4 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 5| 6| 5| 7| 5| 7| 6| 5| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 0| 0| 0| 3| 1| 6| 3| 3| 3| 7| 6| 0| 3| 9| 3| 3| 3| 2| 3| 3| 2| 3|
| 2| 7| 9| 4| 9| 0| 2| 9| 3| 6| 5| 6| 8| 1| 3| 5| 0| 7| 6| 2| 0| 7| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Papilla, Angiectasis | 2 2 1 |
Papilla, Inflammation, Acute | |
Papilla, Necrosis, Coagulative | 4 4 4 |
Papilla, Necrosis | 3 2 2 2 2 3 2 4 1 2 3 3 2 2 2 2 2 2 2 2 2|
Pelvis, Calculus Gross Observation | |
Pelvis, Dilatation | 2 1 1 4 2 2 3 2 1 2 2 2 2 2 2|
Pelvis, Epithelium, Hyperplasia | 1 2 4 2 3 1 2 2 2 2 2 2 2 1 1 3 2 1 2 1|
Pelvis, Epithelium, Mineralization | 2 2 |
Proximal Convoluted Renal Tubule, | |
Hyperplasia | |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 2 1 1 1 1 1 2 1 1 1|
Proximal Convoluted Renal Tubule, | |
Mineralization | 4 |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Ureter | + |
Dilatation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal, | |
Necrotizing | 2 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7| |
DAY ON TEST | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2| |
| 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M M + M + M + + M + + + M + + M + M + + + M + M| 25 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | 2 | 1 2.0|
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 | 1 1.0|
Parasite Metazoan | 1 X 2 1 | 6 1.2|
Mucosa, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Metaplasia, Focal, Squamous | 2 | 1 2.0|
Parasite Metazoan | 2 | 1 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Chronic | | 1 4.0|
Inflammation, Chronic Active, | | |
Necrotizing | 4 4 | 2 4.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
Muscularis, Inflammation, Acute | 3 | 1 3.0|
Muscularis, Mineralization | 2 | 1 2.0|
Serosa, Fibrosis | | 1 1.0|
Serosa, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoid Nodule, Depletion Cellular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active, | | |
Necrotizing | | 1 4.0|
Ulcer | | 1 4.0|
Muscularis, Inflammation, Acute | 2 | 1 2.0|
Muscularis, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | 1 1 1 1 1 1 1 2 1 1 1 1 1 | 31 1.0|
Clear Cell Focus | | 3 1.3|
Eosinophilic Focus | | 2 1.0|
Fatty Change | 1 1 2 2 2 1 2 1 3 1 | 19 1.5|
Focal Cellular Change | 2 | 1 2.0|
Hemorrhage | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7| |
DAY ON TEST | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2| |
| 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 2 3.0|
Inflammation, Chronic Active | 1 1 1 2 1 | 10 1.3|
Necrosis, Coagulative | 1 1 4| 5 1.8|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 | 23 1.1|
Centrilobular, Cytomegaly | | 1 3.0|
Kupffer Cell, Hyperplasia, Focal | 2 | 1 2.0|
Periportal, Fibrosis | 2 | 1 2.0|
Serosa, Inflammation, Suppurative | | 1 2.0|
Subserosa, Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 10 |
Fibrosis | | 2 2.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic Active | 4 3 2 2 | 5 2.6|
Mineralization | 2 | 4 1.5|
Necrosis, Coagulative | 3 | 5 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 1 1 1| 11 1.3|
Inflammation, Chronic | 2 1 | 7 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Acanthosis | 1 2 2 2 2 2| 12 2.0|
Edema | | 1 3.0|
Erosion | 2 | 1 2.0|
Hyperkeratosis | 1 2 2 2 2 2| 12 2.1|
Hyperplasia, Basal Cell | 2 2 2 2 2 2| 12 2.1|
Inflammation, Chronic Active | | 1 3.0|
Ulcer | 2 2 3 4 2 2| 12 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 4.0|
Edema | | 1 2.0|
Erosion | 2 | 2 2.0|
Inflammation, Chronic Active | 1 | 5 1.4|
Mineralization | 2 3 3| 4 2.8|
Ulcer | 3 | 3 3.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 2 2 1 2 1 1 2 2 2 1 1 2 1 2 2 2| 43 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7| |
DAY ON TEST | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2| |
| 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mineralization | 4 2 | 3 2.7|
Necrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 1 2 | 17 1.1|
Degeneration, Fatty | 2 | 1 2.0|
Hyperplasia | 1 1 2 1| 9 1.2|
Necrosis, Coagulative | 2 | 2 3.0|
Vacuolization Cytoplasmic | 1 1 2 1 1 1 2 1 2 1 1 1 2| 31 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1 1 1 1 | 19 1.1|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M M M M + M M M + M M M + M M M M + M M + M| 14 |
Hyperplasia | 4 2 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 2 3 2 1 2 2 1 2 3 1 1| 30 2.3|
Pars Distalis, Cyst | 1 1 1 3 2 2 1 1 2 1 1 2| 23 1.4|
Pars Distalis, Hyperplasia | 1 1 2 2 2 1 1 1 | 15 1.3|
Pars Distalis, Pigmentation | 1 1 1 | 6 1.2|
Pars Intermedia, Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1| 24 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + + + + + + M + + + + + + M M + +| 41 |
Inflammation, Acute | 1 2 | 3 2.3|
Inflammation, Chronic | 1 1 | 6 1.0|
Inflammation, Chronic Active | 1 2 1 1 2 3 | 17 1.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 1 2 | 9 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7| |
DAY ON TEST | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2| |
| 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | 1 | 1 1.0|
Endometrium, Hyperplasia | 2 2 3 | 7 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Myelofibrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mediastinal, Depletion Lymphoid | | 1 3.0|
Mediastinal, Hemorrhage | 1 3 3 3 2 | 11 1.9|
Mediastinal, Inflammation, Chronic | | |
Active | | 1 2.0|
Renal, Ectasia | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Renal, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M M + M + + + +| 37 |
Depletion Lymphoid | 2 | 1 2.0|
Ectasia | 3 | 1 3.0|
Hemorrhage | 2 2 | 7 2.3|
Hyperplasia | 1 | 5 1.6|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + M +| 46 |
Depletion Lymphoid | | 2 2.0|
Ectasia | 2 | 5 2.4|
Hemorrhage | 1 2 | 4 1.3|
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 3 3 2 1 2 2 2 2 2| 19 2.2|
Hematopoietic Cell Proliferation | 2 | 4 2.0|
Pigmentation | 2 | 1 2.0|
Subcapsular, Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M M + + + + + M + + + + M + + + + + + M + M + +| 38 |
Congestion | 2 | 2 2.5|
Cyst | 2 | 2 2.0|
Depletion Lymphoid | 2 2 3 4 3 3 3 2 2 3 2 3 3 3 3| 32 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7| |
DAY ON TEST | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2| |
| 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + M + + + + M M + + M M + M| 40 |
Degeneration | | 1 2.0|
Galactocele | | 1 2.0|
Hyperplasia | 3 2 3 2 3 2 1 2 2 3 2 2 1 | 32 2.1|
__________________________________________________________________________|____________|
Skin | + + I + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 1 2.0|
Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 | 2 2.0|
Edema | 3 2 | 2 2.5|
Foreign Body | 1 2 4 | 4 2.5|
Granuloma | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1| 22 1.0|
Inflammation, Acute | 4 1 3 | 3 2.7|
Inflammation, Acute, Necrotizing | 4 | 1 4.0|
Inflammation, Chronic | 1 1 1 | 8 1.0|
Inflammation, Chronic Active | 2 1 1 | 6 1.5|
Thrombosis, Multiple | 1| 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Artery, Mineralization | 1 1 1 1 1 4 | 19 1.2|
Bronchus, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 2 1 1 | 3 1.3|
Inflammation, Acute, Necrotizing | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7| |
DAY ON TEST | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2| |
| 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Necrotizing | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | I I | |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | | 3 4.0|
Cyst | 1 1 1 1 2 1| 16 1.4|
Inflammation, Acute, Necrotizing | | 2 4.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Inflammation, Chronic Active, | | |
Necrotizing | | 2 4.0|
Nephropathy | 3 3 3 4 3 3 2 2 3 3 2 4 4 3 4 4 3 1 2 3 4 3 4 4| 47 3.3|
Pigmentation | 2 | 1 2.0|
Collecting Tubule, Mineralization | 3 3 1 4 1 3 2 1 2 2 2 3 3 2 2 2 2 2 1 2 3 2| 46 2.2|
Papilla, Angiectasis | 2 | 4 1.8|
Papilla, Inflammation, Acute | 2 2 | 2 2.0|
Papilla, Necrosis, Coagulative | 2 2 1 | 6 2.8|
Papilla, Necrosis | 3 2 2 2 2 2 2 2 2 2 2 2 4 2| 35 2.2|
Pelvis, Calculus Gross Observation | X | 1 |
Pelvis, Dilatation | 2 1 2 2 3 2 2| 22 2.0|
Pelvis, Epithelium, Hyperplasia | 2 1 2 2 2 1 1 2 1 2 2 2 2 3 2 2 2| 37 1.9|
Pelvis, Epithelium, Mineralization | 1 1 2 3 | 6 1.8|
Proximal Convoluted Renal Tubule, | | |
Hyperplasia | 1 | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 2 1 2 2 1 1 2 1 1 1 1 1 2 2 1| 26 1.3|
Proximal Convoluted Renal Tubule, | | |
Mineralization | 2 4 2 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 6| 6| 7| 7| 6| 7| 4| 7| 4| 6| 1| 5| 5| 7| |
DAY ON TEST | 2| 3| 3| 8| 3| 1| 3| 0| 3| 3| 8| 7| 5| 3| 3| 7| 3| 1| 3| 8| 1| 1| 5| 1| 2| |
| 1| 5| 5| 5| 5| 8| 7| 8| 5| 5| 5| 3| 3| 5| 5| 3| 5| 7| 5| 9| 7| 5| 4| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Proximal Convoluted Renal Tubule, | | |
Pigmentation | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Inflammation, Acute, Focal, | | |
Necrotizing | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|
| 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + M + + + + + + M + + + M + +|
Submucosa, Hemorrhage | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Parasite Metazoan | 2 2 1 X 1 X 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1|
Clear Cell Focus | 1 1 1 1 1 1 |
Degeneration, Cystic | 1 1 1 |
Eosinophilic Focus | 2 2 1 |
Fatty Change | 2 2 2 1 2 1 2 1 2 2 1 2 1 2 1 2 2 2 2 1 1|
Fibrosis | |
Hemorrhage | |
Inflammation, Chronic Active | 1 2 2 1 1 1 1 1 1 1 2 1 1 1|
Mixed Cell Focus | 2 2 2 |
Necrosis, Coagulative | 1 1 3 1 2 |
Bile Duct, Hyperplasia | 2 2 2 2 1 1 1 2 2 1 2 1 2 2 2 1 1|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Ectopic Tissue | X |
Hyperplasia | 2 2 2 3 3 |
Inflammation, Chronic | 1 1 1 1|
Pigmentation | |
Acinus, Hyperplasia | 1 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|
| 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Basal Cell | 2 1 |
Muscularis, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | 2 |
Ulcer | |
Arteriole, Mineralization | |
Muscularis, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 1 1 2 2 2 3 1 1 2 1 1 2 2 2 2 2 2 1 2|
Atrioventricular Valve, | |
Mineralization, Focal | 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 2 1 1 1 2 2 2 3 1 1 1|
Atrophy | 3 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 2 3 1 1 3 1 2 2 2 3 1 1 1|
Fibrosis | |
Hyperplasia | 1 1 1 1 1 1 1|
Mineralization | |
Necrosis | |
Thrombosis | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + M + M M + M + M + + M M + M + + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 1 1 1 2 1 1 1 1 1 |
Pars Distalis, Necrosis, Coagulative | |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|
| 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Mineralization | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | 3 2 1 2 2 2 3 2 2|
__________________________________________________________________________|
Preputial Gland | + + M + + M + + + + + + + + + M + M + + + + + + +|
Fibrosis | |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 1 1 2 |
Inflammation, Chronic Active | 4 3 1 2 2 1 1 2 3 3 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Acute | 1 1 1 2 |
Inflammation, Chronic Active | 3 3 2 2 |
Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 2 2 2 2 2 2 1 2 2 2 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Chronic | |
Active | 2 |
Arteriole, Necrosis, Fibrinoid | 2 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 3 4 3 4 3 4 4 3 1 4 1 3 1 3 2 3 4 4 3 4 4 4|
Seminiferous Tubule, Mineralization | 1 1 |
Seminiferous Tubule, Necrosis, | |
Coagulative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 1 |
Mediastinal, Ectasia | 3 |
Mediastinal, Hemorrhage | 1 1 2 |
Mediastinal, Hyperplasia | 2|
Mediastinal, Pigmentation | 1 |
Pancreatic, Angiectasis | 2 |
Pancreatic, Fibrosis | 2 |
Pancreatic, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|
| 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + M + M + + + + M + + + + + +|
Angiectasis | 1 |
Congestion | |
Ectasia | 2 2 1 3 3 |
Hemorrhage | 3 |
Hyperplasia | 2 2 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + M + + + + + + + M|
Angiectasis | 2 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 1 |
Depletion Lymphoid | 2 1 3 2 |
Fibrosis | 2 4 |
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M + + + + + + + + + + + +|
Cyst | 2 2 |
Depletion Lymphoid | 2 3 3 2 2 2 2 2 2 2 3 2 2 3 3 2 3 2 3 3 2|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M + M M M M M M M M + + M M + + M + M|
Hyperplasia | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Atrophy | 4 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active, | |
Necrotizing | 4 3 |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|
| 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Pigmentation | 2 |
Meninges, Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 |
Fibrosis | 1 1 |
Foreign Body | 1 |
Granuloma | 1 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 2 2 1 1 1 1 1 1 2 1 |
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | 1 2 |
Alveolar Epithelium, Hyperplasia | 1 1|
Artery, Hyperplasia | 2 |
Artery, Mineralization | 1 1 1 1 1 1 1 1|
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Acute | 1 1 1 1 2 1|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 |
Nasopharyngeal Duct, Inflammation, | |
Chronic Active | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | 3 |
Nephropathy | 2 2 1 2 2 2 3 4 2 2 3 3 2 4 1 1 3 2 3 2 3 4 2 4|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 5| 6| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 9| 0| 0| 2| 7| 4| 3| 3| 8| 3| 3| 3|
| 7| 7| 6| 7| 8| 5| 7| 7| 1| 9| 7| 1| 8| 9| 1| 5| 6| 2| 5| 2| 8| 3| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Collecting Tubule, Mineralization | |
Papilla, Necrosis | 1 |
Pelvis, Dilatation | |
Pelvis, Mineralization | |
Pelvis, Epithelium, Hyperplasia | 1 1 1 2 2 2|
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | |
Proximal Convoluted Renal Tubule, | |
Mineralization | |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8| |
| 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + + + + + + + + M + + + + + + + +| 44 |
Submucosa, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + M M + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Parasite Metazoan | 1 1 1 1 1 | 13 1.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 37 1.1|
Clear Cell Focus | 1 1 1 2 2 1 1 1 1 | 15 1.1|
Degeneration, Cystic | 1 | 4 1.0|
Eosinophilic Focus | 3 1 1 2 | 7 1.7|
Fatty Change | 3 1 1 1 1 1 1 2 1 2 2 2 2 2 1 2 2 1 2 2| 41 1.6|
Fibrosis | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 1 2 2 2 1 1 1 1 1 2 1 1 1 1 | 28 1.3|
Mixed Cell Focus | | 3 2.0|
Necrosis, Coagulative | 2| 6 1.7|
Bile Duct, Hyperplasia | 1 2 2 1 1 2 2 1 1 1 1 2 1 2 1 2 1 2 | 35 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Inflammation, Chronic Active | | 1 2.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 4 1 2 | 9 1.7|
Ectopic Tissue | | 1 |
Hyperplasia | 2 2 2 | 8 2.3|
Inflammation, Chronic | 1 1 1 1 | 8 1.0|
Pigmentation | 2 1 | 2 1.5|
Acinus, Hyperplasia | | 1 1.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8| |
| 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 2 | 4 2.0|
Hyperkeratosis | 2 2 | 3 2.0|
Hyperplasia, Basal Cell | 2 2 | 4 1.8|
Muscularis, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Mineralization | | 1 2.0|
Ulcer | 1 | 1 1.0|
Arteriole, Mineralization | 4 | 1 4.0|
Muscularis, Mineralization | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 4 2 1 2 1 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2| 48 1.8|
Atrioventricular Valve, | | |
Mineralization, Focal | | 1 1.0|
Atrium, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 2 1 2 2 1 2 1 1 1 3 1 1 | 29 1.5|
Atrophy | | 1 3.0|
Hyperplasia | 1 1 1 2 1 1 | 7 1.1|
Vacuolization Cytoplasmic | 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2| 32 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 4 1 2 2 1 2 2 1 3 3 1 1 3 1 1 | 34 1.7|
Fibrosis | 2 | 1 2.0|
Hyperplasia | 1 1 2 1 | 11 1.1|
Mineralization | 2 | 1 2.0|
Necrosis | 3| 1 3.0|
Thrombosis | 4 | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M M M M M + M + + M + M + M + + M M M + M| 24 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + + M + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8| |
| 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Angiectasis | 1 4 | 4 2.3|
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Hemorrhage | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 1 2 2 1 1 2 2 2 2 2 2 | 22 1.5|
Pars Distalis, Necrosis, Coagulative | 3 | 1 3.0|
Pars Intermedia, Angiectasis | 4 | 2 3.0|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 | 22 1.0|
Follicle, Cyst | 1 | 1 1.0|
Follicle, Mineralization | 1 | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 1 2 1 2 2 3| 16 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + + + + + + M + + + + + + + + M| 43 |
Fibrosis | 2 | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | 2 1 1 2 2 1 1 2 2 | 16 1.4|
Inflammation, Chronic Active | 2 1 3 4 3 1 2 2 2 2 4 | 22 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Inflammation, Acute | 2 | 5 1.4|
Inflammation, Chronic Active | 2 2 3 1 2 1 3 2 1 2 2 2 3 3 2 | 19 2.2|
Epithelium, Hyperplasia | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 3 3 2 2 2 | 17 2.2|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Inflammation, Chronic | | |
Active | 2 | 2 2.0|
Arteriole, Necrosis, Fibrinoid | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| 35 1.1|
Seminiferous Tubule, Atrophy | 3 4 3 4 1 4 4 4 4 4 2 3 1 4 4 4 3 3 4 4 3 3 | 44 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8| |
| 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Mineralization | 1 1 1 | 5 1.0|
Seminiferous Tubule, Necrosis, | | |
Coagulative | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Angiectasis | | 2 1.5|
Mediastinal, Ectasia | | 1 3.0|
Mediastinal, Hemorrhage | 2 2 2 2 2 | 8 1.8|
Mediastinal, Hyperplasia | | 1 2.0|
Mediastinal, Pigmentation | 2 4 | 3 2.3|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Fibrosis | | 1 2.0|
Pancreatic, Pigmentation | | 1 1.0|
Renal, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + M + + + +| 44 |
Angiectasis | | 1 1.0|
Congestion | 2 | 1 2.0|
Ectasia | 2 4 4 2 2| 10 2.5|
Hemorrhage | 2 1 1 2 | 5 1.8|
Hyperplasia | 1 1 2 2 | 7 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | | 1 2.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.1|
Pigmentation | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 1.0|
Depletion Lymphoid | 3 4| 6 2.5|
Fibrosis | | 2 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Necrosis, Coagulative, Focal | 2| 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M + + + + + + + + + M + + + M + M + + + M + + +| 42 |
Cyst | | 2 2.0|
Depletion Lymphoid | 3 2 2 3 2 2 2 3 3 3 2 3 3 3 2 3| 37 2.5|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8| |
| 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M + M M M + M + + M + M M + M + + + + + M| 21 |
Hyperplasia | 1 1 2 2 1 2 2 3 | 10 1.8|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 4 | 1 4.0|
Atrophy | | 1 4.0|
Cyst Epithelial Inclusion | X | 2 |
Hyperkeratosis | 4 | 1 4.0|
Hyperplasia, Basal Cell | 3 | 1 3.0|
Inflammation, Chronic Active, | | |
Necrotizing | | 2 3.5|
Subcutaneous Tissue, Fibrosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | | 1 2.0|
Pigmentation | | 1 2.0|
Meninges, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 1.5|
Fibrosis | | 2 1.0|
Foreign Body | | 1 1.0|
Granuloma | | 1 1.0|
Hemorrhage | 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 1 1 2 | 13 1.3|
Inflammation, Chronic | 1 1 1 1 1 1 | 11 1.0|
Inflammation, Chronic Active | 1 1 1 2 2 | 7 1.4|
Alveolar Epithelium, Hyperplasia | 2 1 2 1 1 | 7 1.3|
Artery, Hyperplasia | 1 | 2 1.5|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1| 21 1.0|
Bronchiole, Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8| |
| 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 4 | 2 4.0|
Inflammation, Acute | 1 1 1 1 1 | 11 1.1|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 2 1 | 4 1.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 1.0|
Nasopharyngeal Duct, Inflammation, | | |
Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peritracheal Tissue, Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 3 2.0|
Cyst | 1 | 2 2.0|
Nephropathy | 1 4 4 2 1 2 3 2 3 3 2 1 2 1 4 1 4 2 1 2 3 2 3 2 1| 49 2.3|
Collecting Tubule, Mineralization | 1 1 1 1 1 | 5 1.0|
Papilla, Necrosis | | 1 1.0|
Pelvis, Dilatation | 2 | 1 2.0|
Pelvis, Mineralization | 1 | 1 1.0|
Pelvis, Epithelium, Hyperplasia | 2 1 1 2 2 2 2 2 | 14 1.6|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 1 1 1 1 1 1 | 6 1.0|
Proximal Convoluted Renal Tubule, | | |
Mineralization | 1 | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | 3 3 | 2 3.0|
Renal Tubule, Hyperplasia | 1 1 | 3 1.7|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 1| 3| 3| 4| 3| 8| 3| 3| 3| 8| |
| 7| 7| 0| 7| 9| 7| 1| 7| 7| 2| 7| 8| 1| 8| 8| 8| 7| 2| 1| 7| 6| 7| 1| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + M + + + + + + + + M + M + + +| 45 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|
| 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + M + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + M |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + |
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | 1 2 1 1 1 1 1 1 1 2 1 2 |
Clear Cell Focus | 1 3 1|
Congestion | 2 |
Degeneration, Cystic | |
Eosinophilic Focus | 1 1 1 2|
Fatty Change | 2 3 1 2 1 1 2 1 2 2 2 1 3 1 2 2 1 3 2 2 3 2|
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X |
Infarct | 4 |
Inflammation, Chronic Active | 2 2 1 2 2 2 1 2 2 2|
Mixed Cell Focus | 1 2 1 |
Necrosis, Coagulative | 1 1 4 |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 2 2 1 2 2 2 1 2 2 1 1 2 1 2|
Kupffer Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 4 4 |
Necrosis, Coagulative | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Atrophy | 1 |
Hyperplasia | 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 2 2 |
Hyperkeratosis | 1 2 2 3 |
Hyperplasia, Basal Cell | 1 1 2 2 2 |
Hyperplasia, Pseudoepitheliomatous | |
Inflammation, Chronic Active | 1 3 |
Ulcer | 4 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|
| 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | |
Mineralization | |
Mucosa, Mineralization | |
Mucosa, Necrosis | 2 |
Muscularis, Mineralization | 1 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Cardiomyopathy | 2 3 2 1 2 2 1 2 2 1 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 1 1 1 3 2 1 2 |
Congestion | |
Hyperplasia | 1 1 1 1 |
Vacuolization Cytoplasmic | 1 3 3 2 1 1 1 2 1 2 1 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 4 2 1 1 3 2 2 3|
Hyperplasia | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M + M M M M M M |
__________________________________________________________________________|
Pituitary Gland | + + + M + + M + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia | 2 1 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Epithelium, Hyperplasia | 1 3 2 2 2 2 2 1 1 2 2 1 3 3 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + |
Abscess | |
Inflammation, Chronic | 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|
| 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 4 1 4 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + |
Atrophy | 4 3 3 3 3 4 3 3 |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Testes | + + + + + + M + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 1 2 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 1 4 1 4 4 4 4 4 3 4 4 4 1 4 4|
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + M M + + M + + + + + + |
Mediastinal, Depletion Lymphoid | |
Mediastinal, Ectasia | 1 |
Mediastinal, Hemorrhage | |
Mediastinal, Inflammation, Chronic | |
Active | |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 |
Renal, Hemorrhage | 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + M + + + + + + |
Ectasia | |
Hemorrhage | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M M + + M + + + + + + |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + + + |
Congestion | |
Depletion Lymphoid | 2 1 2 2 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 |
Pigmentation | |
Capsule, Inflammation, Chronic | |
Active, Necrotizing | 4 |
__________________________________________________________________________|
Thymus | + + + M + + + M + + |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|
| 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 2 2 2 2 2 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M M M M M + M M |
Galactocele | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | |
Hyperplasia, Pseudoepitheliomatous | 2 |
Inflammation, Acute, Hemorrhagic | 2|
Inflammation, Acute, Necrotizing | 4 |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
Autolysis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Third Ventricle, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Congestion | 2 1 4 2 3 2 |
Crystals | |
Edema | |
Fibrosis | 1 |
Granuloma | 1 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | |
Artery, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 1 |
Bronchus, Bronchiectasis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 5| 7| 5| 7| 6| 7| 3| 6| 6| 5| 5| 6| 7| 7| 5| 7| 5| 6| 7|
DAY ON TEST | 3| 3| 0| 4| 9| 3| 1| 3| 9| 3| 1| 3| 8| 4| 0| 8| 9| 1| 3| 2| 7| 3| 4| 7| 2|
| 0| 4| 3| 5| 6| 4| 8| 4| 6| 1| 5| 4| 0| 1| 2| 3| 2| 9| 4| 9| 6| 4| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.05 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | 4 3 |
Hemorrhage | |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | 2 4 4 3 4 4 4 2 3 2 4 4 3 2 2 2 3 4 3 3 4 2 4 3|
Collecting Tubule, Mineralization | 1 1 1 1 |
Papilla, Necrosis | 1 1 1 1|
Pelvis, Dilatation | 2 |
Pelvis, Epithelium, Hyperplasia | 1 1 1 1 2 |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 1 1 1|
Proximal Convoluted Renal Tubule, | |
Mineralization | 1 |
Proximal Convoluted Renal Tubule, | |
Pigmentation | 3 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + |
Calculus Micro Observation Only | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1| |
| 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + M + + | 17 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M M + M M + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 21 |
Parasite Metazoan | 2 | 3 1.7|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + M + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.0|
Basophilic Focus | 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1| 27 1.2|
Clear Cell Focus | 1 1 1 2 3 1 1 2 | 11 1.5|
Congestion | | 1 2.0|
Degeneration, Cystic | 1 | 1 1.0|
Eosinophilic Focus | 1 2 1 1 1 | 9 1.2|
Fatty Change | 2 2 3 2 2 2 3 2 2 2 2 1 2 2 2 1 2| 39 1.9|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Infarct | | 1 4.0|
Inflammation, Chronic Active | 1 1 1 2 1 2 2 2 2 2 1 2 1 | 23 1.7|
Mixed Cell Focus | 1 | 4 1.3|
Necrosis, Coagulative | 2 3 2 | 6 2.2|
Bile Duct, Hyperplasia | 1 2 2 2 1 2 1 1 1 1 1 2 1 2 1 2 1 2 2 2 1 1| 43 1.5|
Kupffer Cell, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Inflammation, Chronic Active | | 2 4.0|
Necrosis, Coagulative | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 27 |
Atrophy | 3 | 2 2.0|
Hyperplasia | 2 | 3 1.3|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 23 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 2 2 3| 8 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1| |
| 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 3 2 2 3| 8 2.3|
Hyperplasia, Basal Cell | 2 2 2 3| 9 1.9|
Hyperplasia, Pseudoepitheliomatous | 2 | 1 2.0|
Inflammation, Chronic Active | 1 | 3 1.7|
Ulcer | 4 4 4| 5 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Mineralization | 1 | 1 1.0|
Mucosa, Mineralization | 2 | 1 2.0|
Mucosa, Necrosis | | 1 2.0|
Muscularis, Mineralization | | 3 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 20 |
Cardiomyopathy | 2 1 2 1 2 1 2 1 | 18 1.7|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 1 2 1 2 1 1 2 2 | 19 1.6|
Congestion | 3 | 1 3.0|
Hyperplasia | 1 1| 6 1.0|
Vacuolization Cytoplasmic | 1 2 1 2 3 1 1 1 2 1 1 1 1 2| 26 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 1 1 2 2 1 2 1 4 2 1 2 1 2 | 23 2.0|
Hyperplasia | 1 2 1 2 2 1| 15 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + M M + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + +| 26 |
Pars Distalis, Angiectasis | 1 | 1 1.0|
Pars Distalis, Cyst | | 1 3.0|
Pars Distalis, Hyperplasia | 1 1 1 1 2 2| 8 1.4|
Pars Distalis, Pigmentation | 1 1 | 2 1.0|
Pars Intermedia, Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 21 |
C-Cell, Hyperplasia | 2 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1| |
| 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 3 2 2 2 2 2 1 1 3 1| 26 1.9|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + + + + + | 25 |
Abscess | 3 | 1 3.0|
Inflammation, Chronic | 2 2 1 2 | 7 1.6|
Inflammation, Chronic Active | 3 4 4 2 2 2 3 | 12 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + | 21 |
Inflammation, Acute | 2 2 2 | 3 2.0|
Inflammation, Chronic Active | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + A + + + + + + M +| 36 |
Atrophy | 2 2 2 4 3 2| 14 2.9|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1| 14 1.2|
Seminiferous Tubule, Atrophy | 4 4 2 4 4 4 4 4 4 4 4 4 4 2 2 3 4 4 1| 41 3.5|
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 | 26 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + | 26 |
Mediastinal, Depletion Lymphoid | 4 | 1 4.0|
Mediastinal, Ectasia | | 1 1.0|
Mediastinal, Hemorrhage | 1 | 1 1.0|
Mediastinal, Inflammation, Chronic | | |
Active | 4 | 1 4.0|
Mediastinal, Pigmentation | 1 1 | 2 1.0|
Pancreatic, Hemorrhage | 3 | 1 3.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M M + + | 18 |
Ectasia | 3 | 1 3.0|
Hemorrhage | 2 3 | 3 2.3|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + | 19 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1| |
| 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 1 | 4 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + +| 32 |
Congestion | 3 | 1 3.0|
Depletion Lymphoid | 2 2 3 3 2 1 3 2 3| 13 2.2|
Fibrosis | 2 | 2 2.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Pigmentation | 3 | 1 3.0|
Capsule, Inflammation, Chronic | | |
Active, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + | 18 |
Congestion | 2 | 1 2.0|
Depletion Lymphoid | 1 3 4 3 2 3 1 | 13 2.2|
Hemorrhage | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M M + + M M M M M | 8 |
Galactocele | | 1 2.0|
Hyperplasia | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 27 |
Acanthosis | 3 | 2 2.5|
Hyperkeratosis | 3 | 1 3.0|
Hyperplasia, Pseudoepitheliomatous | | 1 2.0|
Inflammation, Acute, Hemorrhagic | | 1 2.0|
Inflammation, Acute, Necrotizing | | 1 4.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Subcutaneous Tissue, Fibrosis | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 21 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 20 |
Third Ventricle, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1| |
| 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + +| 34 |
Congestion | 2 3 2 4 | 10 2.5|
Crystals | 4 | 1 4.0|
Edema | 2 1 | 2 1.5|
Fibrosis | | 1 1.0|
Granuloma | | 1 1.0|
Hemorrhage | 4 | 2 2.5|
Infiltration Cellular, Histiocyte | 1 1 1 4 1 1 1 1 1 | 13 1.2|
Inflammation, Chronic | 2 1 1 | 4 1.3|
Inflammation, Chronic Active | 4 1 | 3 2.3|
Alveolar Epithelium, Hyperplasia | 1 1 1 | 3 1.0|
Artery, Hyperplasia | 2 | 1 2.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1| 16 1.0|
Bronchus, Bronchiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + M + + + + | 19 |
Edema | | 2 3.5|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 2 | 3 1.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Osseous | 4 | 1 4.0|
Nephropathy | 4 3 2 4 2 3 3 4 4 4 1 3 3 3 2 4 1 2 4 3 2 1 2 3 4| 49 3.0|
Collecting Tubule, Mineralization | 1 1 1 1 1 1 | 10 1.0|
Papilla, Necrosis | 1 1 1 1 1 2 | 10 1.1|
Pelvis, Dilatation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 4| 6| 6| 7| 6| 7| 2| 6| 7| 6| 7| 6| 4| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 7| 2| 2| 2| 4| 5| 2| 3| 0| 3| 8| 2| 3| 3| 3| 2| 7| 2| 1| |
| 4| 4| 2| 0| 5| 4| 1| 4| 9| 9| 7| 3| 6| 0| 6| 4| 3| 1| 1| 4| 1| 9| 1| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0.05 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
G/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Epithelium, Hyperplasia | 1 2| 7 1.3|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 1 1 1 1 1 2 1 1| 13 1.1|
Proximal Convoluted Renal Tubule, | | |
Mineralization | | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | | 1 3.0|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 22 |
Calculus Micro Observation Only | X | 1 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|
| 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + M + + + + + + + + + + + + + + M M M + + M + +|
Inflammation, Acute, Necrotizing | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | 4 |
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 2 X 2 1 1 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 1 1 2 X 1 1 1 1 1 1 1 1|
Clear Cell Focus | 1 1 1 1 2 1 1 1 |
Degeneration, Cystic | 1 2|
Eosinophilic Focus | 1 1 2 2 |
Fatty Change | 1 2 1 2 1 1 3 2 1 2 1 2 2 2 2 2 1 1 1 1 2 2 1 2 1|
Hepatodiaphragmatic Nodule | |
Hyperplasia | 3 2 |
Inflammation, Chronic Active | 1 1 1 1 2 2 1 1 1|
Mixed Cell Focus | 1 1 1|
Necrosis, Coagulative | 1 1 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 2 1 1 1 1 2 2 2 1 1|
Centrilobular, Cytomegaly | |
__________________________________________________________________________|
Mesentery | + |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 1 1 1 |
Hyperplasia | 2 2|
Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2|
Inflammation, Chronic | |
Parotid Gland, Atrophy | 1 |
Submandibular Gland, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|
| 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acanthosis | 2 2 2 |
Hyperkeratosis | 1 2 2 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Chronic Active | 1 2 |
Ulcer | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic Active | 2 2 2 1 |
Mineralization | |
Ulcer | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 4 2 2 2 1 3 2 2 2 2 2 2 2 2 2 1 3 2 2|
Atrium, Congestion | |
Atrium, Thrombosis | 3 X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 3 1 2 |
Hyperplasia | 1 1 1 2 |
Vacuolization Cytoplasmic | 1 3 2 1 1 2 1 1 1 2 3 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 4 2 3 3 1 3 2 |
Hyperplasia | 2 1 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M M + M M M + M + M M + + M M M + + M + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + M M + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 2|
Pars Distalis, Hyperplasia | 1 2 1 1 2 2 1 2 1 1 2 2 1 3 1 1|
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + I + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1|
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|
| 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 2 2 1 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 3 1 2 2 1 1 2 3 2 4 1 2 1 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + M + + + +|
Cyst | |
Inflammation, Acute | 1 3 2 1 1 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 2 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + M + + + + + + M + + + +|
Atrophy | 3 3 2 3 3 3 3 3 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 2 4 3 4 4 4 2 4 3 4 3 4 4 4 4 4 4 2 1 4 4 4 |
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Necrosis, | |
Coagulative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Depletion Lymphoid | |
Mediastinal, Hemorrhage | 3 1 |
Mediastinal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + M + + M +|
Congestion | |
Ectasia | 3 3 |
Hematocyst | |
Hemorrhage | 2 2 2 |
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 1 1 1|
Pigmentation | 1 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hemorrhage | 1 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|
| 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 2 2 4 3 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Thymus | + + M M + + + + + M M + + + + + M M + + + + + + +|
Cyst | |
Depletion Lymphoid | 1 2 3 2 3 1 3 3 3 2 2 2 3 3 3 2 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M M + M + + + + + M + M M + + + + M +|
Hyperplasia | 2 1 2 2 2 2 1 2 2 1 1 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 3 2 |
Hyperplasia, Basal Cell | 3 2 |
Inflammation, Chronic Active | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Hemorrhage | |
Thalamus, Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Crystals | |
Edema | |
Granuloma | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1|
Metaplasia, Focal, Osseous | 1 |
Pigmentation | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Bronchiole, Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 1| 3| 0| 1| 3| 3| 6| 3| 0| 3| 3| 3| 1| 3| 3| 9| 3| 3| 0| 3| 3| 4| 3| 4| 3|
| 4| 2| 5| 6| 1| 1| 7| 0| 3| 0| 2| 0| 1| 0| 0| 2| 0| 1| 5| 1| 1| 8| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute | 1 1 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 4 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Necrotizing | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + I + |
Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Cyst | 1 |
Nephropathy | 1 4 4 4 4 3 1 3 4 4 3 3 3 4 4 3 4 3 1 2 4 1 4 1 4|
Collecting Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Papilla, Necrosis, Coagulative | |
Papilla, Necrosis | 2 2 2 1 2 2 1 2 2 2 2 2 2 1 2 |
Pelvis, Dilatation | 1 |
Pelvis, Epithelium, Hyperplasia | 2 1 2 1 2 1|
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7| |
| 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M M + M M + + M M + + + + + + + M M M M M + M +| 32 |
Inflammation, Acute, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Necrotizing | | 1 4.0|
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 1 1 1 | 12 1.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Necrotizing | 3 | 1 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 1.5|
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 3 | 25 1.1|
Clear Cell Focus | 1 1 1 2 1 1 1 1 1 1 1 | 19 1.1|
Degeneration, Cystic | 1 1 | 4 1.3|
Eosinophilic Focus | 2 1 1 1 1 1 | 10 1.3|
Fatty Change | 1 1 2 1 1 2 1 1 1 1 1 1 2 1 2 1 2 2 1 2 2 1 1 1| 49 1.4|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia | 3 | 3 2.7|
Inflammation, Chronic Active | 1 1 1 2 2 1 1 1 | 17 1.2|
Mixed Cell Focus | 1 3 1 2 | 7 1.4|
Necrosis, Coagulative | 1 3 | 5 1.4|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2| 32 1.2|
Centrilobular, Cytomegaly | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 3 2 1 1 1 1 1 | 15 1.3|
Hyperplasia | 3 2 1 1 | 6 1.8|
Inflammation, Chronic | 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7| |
| 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 | 1 3.0|
Parotid Gland, Atrophy | | 1 1.0|
Submandibular Gland, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 2 2 2 | 7 2.1|
Hyperkeratosis | 2 2 2 2 | 7 1.9|
Hyperplasia, Basal Cell | 2 | 2 2.0|
Inflammation, Chronic Active | | 2 1.5|
Ulcer | 4 2 4 4 | 6 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 2 2.0|
Inflammation, Chronic Active | 1 1 | 6 1.5|
Mineralization | 2 | 1 2.0|
Ulcer | 4 | 1 4.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 1 2 1 2 2 2 1 1 2 2 1 1 4 2 2 2| 48 2.0|
Atrium, Congestion | 3 | 1 3.0|
Atrium, Thrombosis | X | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 2 2 1 2 2 1 1 | 18 1.4|
Hyperplasia | 3 1 1 1 1 | 9 1.3|
Vacuolization Cytoplasmic | 1 2 1 2 3 1 1 2 1 1 1 2 1 1 2 1 | 32 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 2 1 1 2 2 1 1 2 2 2 2 | 23 1.9|
Hyperplasia | 1 1 1 2 3 1 | 12 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M M M + + M M M + + M M M M M + M M M + +| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Hyperplasia | 1 1 1 1 2 1 1 2 1 1 | 26 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7| |
| 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Angiectasis | | 1 3.0|
Pars Intermedia, Cyst | 1 | 1 1.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 1 1 1 | 17 1.1|
Follicle, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 3 2 2 1 2 2 1 2 2 1 2 1 2 | 26 1.8|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + M| 47 |
Hyperplasia | | 1 2.0|
Inflammation, Acute | 2 | 2 2.5|
Inflammation, Chronic | 2 1 1 1 1 1 1 | 7 1.1|
Inflammation, Chronic Active | 1 2 1 2 2 1 2 2 2 2 2 2 2 | 36 1.9|
__________________________________________________________________________|____________|
Prostate | + + + M + + + + + + + + + + M + + + + + + + + + +| 46 |
Cyst | 3 | 1 3.0|
Inflammation, Acute | 2 1 2 2| 9 1.7|
Inflammation, Chronic | 1 | 4 1.0|
Inflammation, Chronic Active | 2 2 2 1 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 3 3 1 3 3 3 3 3 3 1 3 3 3 | 23 2.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 | 29 1.0|
Seminiferous Tubule, Atrophy | 4 4 4 1 3 4 2 1 4 4 4 4 2 4 4 4 4 4 4 4 3 4 2| 45 3.4|
Seminiferous Tubule, Mineralization | 1 1 1 1 1 | 14 1.0|
Seminiferous Tubule, Necrosis, | | |
Coagulative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Depletion Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7| |
| 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage | 2 2 2 2 2 | 7 2.0|
Mediastinal, Pigmentation | 4 1 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + M + + + + M + + + + M M + + + + M| 41 |
Congestion | 4 | 1 4.0|
Ectasia | | 2 3.0|
Hematocyst | X | 1 |
Hemorrhage | 1 2 | 5 1.8|
Hyperplasia | 2 | 2 2.0|
Infiltration Cellular, Histiocyte | | 3 1.0|
Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 1.0|
Hemorrhage | 3 2 1 | 5 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Depletion Lymphoid | 1 1 1 3| 9 2.2|
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Hyperplasia, Reticulum Cell | 2 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + M + + + + + + + + + + + +| 42 |
Cyst | 2 | 1 2.0|
Depletion Lymphoid | 2 2 2 2 2 3 2 2 3 2 4 2 2 3 4 2 2 2 3 3 3 2| 38 2.4|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M + M M M M + M M M M M M + M M + + M M M| 24 |
Hyperplasia | 2 2 2 2 3 1 | 19 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Acanthosis | | 2 2.5|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | | 2 2.5|
Hyperplasia, Basal Cell | | 2 2.5|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7| |
| 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Hemorrhage | 1 | 1 1.0|
Thalamus, Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3| 4 2.3|
Crystals | 1 | 1 1.0|
Edema | 1 | 1 1.0|
Granuloma | 1 | 2 1.5|
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 12 1.0|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | 1 1 1 2 | 6 1.2|
Metaplasia, Focal, Osseous | | 1 1.0|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 | 5 1.0|
Artery, Hyperplasia | | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 | 24 1.0|
Bronchiole, Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 2 2.0|
Inflammation, Acute | 4 1 | 5 1.6|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 3 | 2 3.5|
Nasolacrimal Duct, Inflammation, | | |
Acute | 4 | 1 4.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 2 2.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 4 2 1| 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Necrotizing | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | I I + I | 3 |
Cataract | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05063-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PHENYLBUTAZONE Date: 05/01/97
Route: GAVAGE Time: 07:53:22
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| |
DAY ON TEST | 8| 3| 1| 3| 6| 3| 5| 9| 2| 2| 3| 9| 3| 3| 3| 3| 8| 1| 3| 3| 3| 3| 9| 3| 7| |
| 1| 1| 6| 1| 4| 1| 8| 8| 0| 1| 2| 4| 2| 2| 2| 2| 9| 5| 0| 2| 2| 2| 4| 0| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
0.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 1 2 1 2 2 | 8 1.6|
Cyst | 1 | 2 1.0|
Nephropathy | 2 4 4 4 4 3 2 2 1 4 3 2 4 2 3 2 3 4 3 3 3 3 4 4 2| 50 3.0|
Collecting Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
Papilla, Necrosis, Coagulative | 2 | 1 2.0|
Papilla, Necrosis | 2 2 1 1 1 1 2 2 2| 24 1.7|
Pelvis, Dilatation | | 1 1.0|
Pelvis, Epithelium, Hyperplasia | 1 1 2 2 1 1 | 12 1.4|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | 4 | 1 4.0|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
Renal Tubule, Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Urethra | | 1 |
Calculus Micro Observation Only | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
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---------- END OF REPORT ----------
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