TDMS Study 05063-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05063 PHENYLBUTAZONE TIME: 19:38:46
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56531
CONT: N01-ES-28033 CAS: 50-33-9
PATHOLOGIST: R. FLEISCHMAN
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/08/94
EXP: 05063 PHENYLBUTAZONE TIME: 19:38:46
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56531
CONT: N01-ES-28033 CAS: 50-33-9
PATHOLOGIST: R. FLEISCHMAN
PHENYLBUTAZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 456 519 521 526 589 595 598 599 605 618 |
| 639 641 645 672 683 686 701 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 1 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 381 448 472 519 536 542 577 584 593 597 |
| 603 607 616 620 622 623 627 630 635 642 |
| 646 654 672 680 697 704 717 725 728 |
| CENSORED DEATHS |
| 284 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 494 505 514 520 548 564 567 575 581 598 |
| 632 644 658 689 692 694 703 705 711 715 |
| 716 716 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PHENYLBUTAZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 82.0 74.0 66.0 |
| | |
| | |
|0.05G/KG | 100.0 100.0 100.0 100.0 98.0 93.9 87.8 77.6 55.1 40.8 |
| | |
| | |
|0.1 G/KG | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 80.0 74.0 54.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.05G/KG 0.1 G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 40.8% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.374 P=0.025 P=0.385 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 605.5 610.2 628.8 |
|NATURAL DEATHS (C) | (16.5) (15.2) (16.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 687.7 651.6 683.4 |
|(STANDARD ERROR) | (10.1) (14.2) (10.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PHENYLBUTAZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 732 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 211 421 485 504 506 533 550 590 619 631 |
| 637 651 668 674 680 695 705 714 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 1 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 299 359 379 557 578 619 655 669 681 683 |
| 690 699 704 713 |
| CENSORED DEATHS |
| 337 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1 G/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 115 417 489 500 504 508 511 520 527 554 |
| 563 578 585 585 590 617 619 621 653 659 |
| 661 673 673 703 709 718 721 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PHENYLBUTAZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 732 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 732 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 98.0 98.0 96.0 94.0 88.0 84.0 76.0 62.0 |
| | |
| | |
|0.05G/KG | 100.0 100.0 100.0 96.0 93.9 93.9 93.9 89.8 85.8 71.5 |
| | |
| | |
|0.1 G/KG | 100.0 98.0 98.0 98.0 96.0 96.0 82.0 70.0 58.0 44.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.05G/KG 0.1 G/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 71.5% 44.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.066 P=0.389N P=0.091 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 589.5 591.8 582.2 |
|NATURAL DEATHS (C) | (29.2) (37.9) (23.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 677.9 684.8 648.1 |
|(STANDARD ERROR) | (14.7) (15.4) (16.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PHENYLBUTAZONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
0.05G/KG = 2
0.1 G/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 2 1 3 3 1
| 2 2 33 11
| 212 3 1
P 90 + 223 3
E | 2 2 11
R | 3 22 11
C | 32 221 1
E 80 + 22 1 31
N | 33
T | 22 113 1 3
| 22 1 1
S 70 + 33
U | 22 1 31
R | 13 1
V | 22 33
I 60 + 222
V | 22
A | 2 2 3 3
L | 2 2
50 + 2 22
| 2 2
| 22
|
40 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
PHENYLBUTAZONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE = 1
0.05G/KG = 2
0.1 G/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
| 3 1 2 2 31
| 2 2 31 1 1 2
| 11 2 2
P 90 + 31 1 2 2
E | 1 1 2 2
R | 3 33 1 1 1 2 2
C | 3 3 1 1 2 2
E 80 + 33 22
N | 3 3 1 1 22
T | 33 1 11 22
| 3 3 11 22 2
S 70 + 3 3 1 1
U | 11
R | 3 3 11 1
V | 3 3 1 1
I 60 +
V | 3 3
A | 3 3
L | 33
50 + 33
|
| 33 3
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.