TDMS Study 05067-10 Pathology Tables
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 58-55-9
Lock Date: 07/14/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 4| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5|
| 1| 1| 1| 1| 2| 1| 3| 1| 1| 1| 4| 1| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation, Chronic | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Eosinophilic Focus | 2 2 2 2 |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Focal | |
Mixed Cell Focus | 2 |
Necrosis, Focal | 4 3 |
Vacuolization Cytoplasmic | 2 2 2 2 2 |
Bile Duct, Cyst | 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Mineralization | 1 1 1 |
Glands, Degeneration, Cystic, Focal | 2 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + I + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 4| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5|
| 1| 1| 1| 1| 2| 1| 3| 1| 1| 1| 4| 1| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Angiectasis | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 2 1 2 1 |
Inflammation, Chronic, Focal | 2 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 1 2 |
Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Hemorrhage | 2 |
Hydrometra | 2 2 3 3 2 3 2 3 |
Endometrium, Hyperplasia, Cystic | 3 2 2 1 2 3 2 2 2 2 2 1 2 3 2 3 1 2 2 3 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + +|
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + M + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 4| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5|
| 1| 1| 1| 1| 2| 1| 3| 1| 1| 1| 4| 1| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 3 3 3 2 3 |
Hyperplasia, Lymphoid | 2 3 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M M + + + + + + + M + + + + + + +|
Atrophy | |
Cyst | |
Hyperplasia, Lymphoid | 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 2 |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | 2 |
Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 4| 3| 3| 0| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5|
| 1| 1| 1| 1| 2| 1| 3| 1| 1| 1| 4| 1| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 2 1 2 1 1 1 2 1 1 1 |
Pelvis, Dilatation | |
Renal Tubule, Degeneration | 2 |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| |
DAY ON TEST | 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 8| 6| 3| 5| |
| 5| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 4| 1| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Muscularis, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + M + + + A + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + A + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Eosinophilic Focus | 3 2 | 6 2.2|
Hematopoietic Cell Proliferation | 2| 2 1.5|
Inflammation, Focal | 1 | 1 1.0|
Mixed Cell Focus | 4 | 2 3.0|
Necrosis, Focal | | 2 3.5|
Vacuolization Cytoplasmic | 2 | 6 2.0|
Bile Duct, Cyst | | 1 2.0|
Centrilobular, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 10 |
Fat, Necrosis | 2 3 2 2 3| 8 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3| 1 3.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2| 1 2.0|
Epithelium, Hyperplasia | 1 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2| 1 2.0|
Erosion | | 1 2.0|
Mineralization | 2 | 4 1.3|
Glands, Degeneration, Cystic, Focal | 1 1 | 11 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| |
DAY ON TEST | 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 8| 6| 3| 5| |
| 5| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 4| 1| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 2 | 1 2.0|
Cyst | 2 | 1 2.0|
Hypertrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Cyst | 1 | 1 1.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 2 2 | 3 1.7|
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 1 3.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 2 | 3 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 1 1 2 2 2 2| 12 1.7|
Inflammation, Chronic, Focal | | 1 2.0|
Follicle, Cyst | 2 | 2 2.0|
Follicular Cell, Hyperplasia | 2 4 1 3 | 7 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 2 | 7 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 1 2 | 6 1.8|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Cyst | 2 | 1 2.0|
Hemorrhage | 3 | 2 2.5|
Hydrometra | 2 2 2 2 2 2 2 3 3 2 2 2| 20 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| |
DAY ON TEST | 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 8| 6| 3| 5| |
| 5| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 4| 1| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 2 2 3 2 2 2 3 2 2 1 2 3 2 2 3 3 2 2 3 1| 48 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3| 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 6 |
Mediastinal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + I + + + +| 48 |
Ectasia | | 1 3.0|
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 4 3 3 3 2 2 3 4| 13 2.9|
Hyperplasia, Lymphoid | 2 | 5 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 3 2| 2 2.5|
Cyst | 1 | 1 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Ectasia | 2| 1 2.0|
Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Inflammation, Chronic, Focal | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 2 2 1 2 | 9 1.7|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| |
DAY ON TEST | 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 8| 6| 3| 5| |
| 5| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 4| 1| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Hemorrhage, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Histiocytic | 2| 2 2.0|
Pigmentation | 2| 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Glands, Dilatation, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + +| 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 1 2 1 1 1 1 1 2 1 1 1 1| 25 1.2|
Pelvis, Dilatation | 1 | 1 1.0|
Renal Tubule, Degeneration | 1 1| 3 1.3|
Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 7| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + A + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal, Lymphoid | 2 |
Inflammation, Chronic | 1 1 1 |
Mixed Cell Focus | 3 |
Necrosis, Focal | 2 |
Pigmentation, Focal | |
Vacuolization Cytoplasmic | 2 4 2 2 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | |
Inflammation, Chronic | 3 |
Fat, Necrosis | 4 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Edema | 2 |
Epithelium, Hyperplasia | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 2 |
Mineralization | 2 |
Glands, Degeneration, Cystic, Focal | 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 7| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Cytoplasmic Alteration, Focal | 2 |
Hematopoietic Cell Proliferation | |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + M + + + +|
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
Pars Distalis, Hyperplasia, Focal | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 1 2 2 |
Follicle, Cyst | 2 2 1 2 2 3 |
Follicular Cell, Hyperplasia | 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 2 2 2 2 3 1 2 3 2 3 3 2 |
Endometrium, Hyperplasia, Cystic | 1 2 3 2 2 3 3 2 2 2 2 2 1 3 2 2 2 2 3 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 7| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + I + + + + M + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 4 4 |
Hyperplasia, Lymphoid | 2 3 |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + M + M + + + +|
Atrophy | |
Cyst | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Fibrosis | 2 |
Subcutaneous Tissue, Edema | 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Peripheral Nerve | I |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Harderian Gland | + + + |
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 8| 0| 3| 3| 5| 3| 3| 3| 3| 3| 3|
| 3| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 3| 7| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7.5 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Metaplasia, Focal, Osseous | 1 |
Nephropathy | 2 2 2 1 2 1 1 1 1 2 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 0| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 4| 3| 0| 1| 3| 3| 3| 3| 3| 8| |
| 5| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 4| 3| 2| 1| 3| 3| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
7.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + A + + + + + + + A + + + + + + + + +| 45 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + A + + + + + + + A + + + + + + + + +| 46 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | 2 2 1 | 7 1.9|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Focal, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 3 1.0|
Mixed Cell Focus | | 1 3.0|
Necrosis, Focal | 1 1 1 | 4 1.3|
Pigmentation, Focal | 2 2 | 2 2.0|
Vacuolization Cytoplasmic | 2 2 2 | 8 2.1|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 2 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Edema | | 1 2.0|
Epithelium, Hyperplasia | 3 2 2 1 | 6 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Erosion | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | 1 1 | 3 1.3|
Glands, Degeneration, Cystic, Focal | 2 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 0| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 4| 3| 0| 1| 3| 3| 3| 3| 3| 8| |
| 5| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 4| 3| 2| 1| 3| 3| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
7.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Cytoplasmic Alteration, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hypertrophy, Focal | 4 2 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + + + + + + + + + I + + I + + + + + +| 45 |
Pars Distalis, Cyst | 2 1 | 4 1.8|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 2 | 7 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 2 2 2 2 2 2 2 2 | 13 1.8|
Follicle, Cyst | 3 2 2 3 2 | 11 2.2|
Follicular Cell, Hyperplasia | 3 1 2 2 3 | 8 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 | 3 1.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 5 2.2|
Hemorrhage | 3 | 2 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 0| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 4| 3| 0| 1| 3| 3| 3| 3| 3| 8| |
| 5| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 4| 3| 2| 1| 3| 3| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
7.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | 3 2 2 3 2 2 2 | 19 2.3|
Endometrium, Hyperplasia, Cystic | 3 2 2 2 3 2 1 3 3 3 2 1 1 2 2 1 2 2 2 2| 41 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 4 2.8|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + +| 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 2 | 2 1.5|
Hyperplasia, Lymphoid | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| 46 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 3 2 3 1 2 3 3 2 2 1 4 2 2| 21 2.5|
Hyperplasia, Lymphoid | 3 | 3 2.7|
Infarct | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + M + + + + M + + + + + + + + +| 44 |
Atrophy | 3 3 3 | 3 3.0|
Cyst | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dermis, Fibrosis | 3 | 2 2.5|
Subcutaneous Tissue, Edema | 3 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 2 1 | 6 1.5|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| |
DAY ON TEST | 2| 3| 0| 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 4| 3| 0| 1| 3| 3| 3| 3| 3| 8| |
| 5| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 4| 3| 2| 1| 3| 3| 3| 3| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
7.5 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Glands, Dilatation, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 3.0|
Metaplasia, Focal, Osseous | 2 | 2 1.5|
Nephropathy | 1 2 1 1 1 1 1 1 1 3 1 2 1 1 1 | 27 1.3|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 4 3 | 3 3.3|
Renal Tubule, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2| 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 0| 3| 1| 2| 6| 3| 3| 9| 0| 6|
| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 5| 2| 0| 5| 7| 2| 3| 6| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + A + +|
Polyp Inflammatory | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 |
Eosinophilic Focus | 3 3 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal, Lymphoid | 2 |
Inflammation, Chronic | 1 |
Mixed Cell Focus | 3 |
Necrosis, Focal | 4 2|
Pigmentation, Focal | |
Vacuolization Cytoplasmic | 1 1 |
Hepatocyte, Karyomegaly | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | |
Acinus, Atrophy, Focal | 3 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Vacuolization Cytoplasmic | 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | 1 2 2 1 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + A + +|
Mineralization | 1 1 |
Glands, Degeneration, Cystic, Focal | 1 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 0| 3| 1| 2| 6| 3| 3| 9| 0| 6|
| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 5| 2| 0| 5| 7| 2| 3| 6| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | 2 |
Cytoplasmic Alteration, Focal | 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + M + + + + + + + + + + + + + M + +|
Cyst | 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 2 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 1 2 2 |
Follicle, Cyst | 2 2 2 1 |
Follicular Cell, Hyperplasia | 3 1 1 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 |
Hemorrhage | 2 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
Hemorrhage | 3 |
Hydrometra | 2 3 2 2 3 2 2|
Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 3 2 2 3 2 1 2 3 2 2 2 3 2 1 1 3 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Hyperplasia | 3 |
Iliac, Inflammation, Chronic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + M + + + + + + M + + M + + + + + +|
Ectasia | 2|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 0| 3| 1| 2| 6| 3| 3| 9| 0| 6|
| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 5| 2| 0| 5| 7| 2| 3| 6| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + A + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 3 3 2 2 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Atrophy | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 3 |
Ulcer | 2 3 |
Epidermis, Hyperplasia, Focal | 3 3 |
Pinna, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 1 2 1 |
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 |
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 0| 3| 1| 2| 6| 3| 3| 9| 0| 6|
| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 5| 2| 0| 5| 7| 2| 3| 6| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Cyst | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Metaplasia, Focal, Osseous | 2 2 |
Nephropathy | 1 1 1 1 1 2 1 1 1 1 1 1 1 |
Thrombosis | |
Renal Tubule, Casts Protein | |
Renal Tubule, Degeneration | |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 1| 0| 5| 9| 3| 3| 3| 8| 3| 3| |
| 3| 3| 9| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 4| 5| 9| 3| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Polyp Inflammatory | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | | 1 2.0|
Eosinophilic Focus | 2 2 | 5 2.4|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Focal, Lymphoid | 2 | 2 2.0|
Inflammation, Chronic | 1 2 2 2 | 5 1.6|
Mixed Cell Focus | 2 | 2 2.5|
Necrosis, Focal | | 2 3.0|
Pigmentation, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 4 2 | 5 2.0|
Hepatocyte, Karyomegaly | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 4 | 1 4.0|
Acinus, Atrophy, Focal | 3 | 2 3.0|
Duct, Cyst | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 1 | 2 1.5|
Epithelium, Hyperplasia | 1 1 1 3 2 2 | 12 1.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 2 1 1 | 5 1.2|
Glands, Degeneration, Cystic, Focal | 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 1| 0| 5| 9| 3| 3| 3| 8| 3| 3| |
| 3| 3| 9| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 4| 5| 9| 3| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Cytoplasmic Alteration, Focal | | 3 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + I + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M M + + + + + + + + + + + + M + + +| 42 |
Cyst | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 2 1.5|
Pars Distalis, Hyperplasia, Focal | 2 4 3 2 2 3 | 14 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 2 1 2 1 | 10 1.5|
Follicle, Cyst | 2 | 5 1.8|
Follicular Cell, Hyperplasia | 2 4 | 8 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Degeneration, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 | 5 2.4|
Hemorrhage | 2 | 5 2.6|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 2.5|
Hemorrhage | | 1 3.0|
Hydrometra | 3 3 3 3 2 2 2 2 2 2 2| 18 2.3|
Inflammation, Chronic | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 3 3 2 3 2 3 3 2 2 2 2| 43 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 1| 0| 5| 9| 3| 3| 3| 8| 3| 3| |
| 3| 3| 9| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 4| 5| 9| 3| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2| 4 2.5|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
Hyperplasia | | 1 3.0|
Iliac, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + I + +| 44 |
Ectasia | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 3 | 2 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 1 3 1 2 | 19 2.2|
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 2 3.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 2 2.0|
Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 2 3.0|
Ulcer | | 2 2.5|
Epidermis, Hyperplasia, Focal | | 2 3.0|
Pinna, Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 2 1 1| 11 1.3|
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 3| 1| 0| 5| 9| 3| 3| 3| 8| 3| 3| |
| 3| 3| 9| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 2| 4| 5| 9| 3| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
25 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 2 2.0|
Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cornea, Inflammation, Chronic | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 8 |
Inflammation, Chronic, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 3.0|
Metaplasia, Focal, Osseous | 2 | 3 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Thrombosis | 2 | 1 2.0|
Renal Tubule, Casts Protein | 1 | 1 1.0|
Renal Tubule, Degeneration | 3 | 1 3.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 2| 2| 5| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 4| 5|
| 2| 2| 8| 2| 2| 2| 7| 5| 5| 5| 2| 1| 2| 2| 9| 5| 2| 2| 2| 2| 2| 2| 2| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | |
Hyperplasia, Focal, Lymphoid | 2 |
Inflammation, Chronic | |
Inflammation, Focal | 2 |
Mixed Cell Focus | |
Necrosis, Focal | 1 |
Vacuolization Cytoplasmic | |
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 2 2 1 1|
Glands, Degeneration, Cystic, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Mineralization | 1|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 2| 2| 5| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 4| 5|
| 2| 2| 8| 2| 2| 2| 7| 5| 5| 5| 2| 1| 2| 2| 9| 5| 2| 2| 2| 2| 2| 2| 2| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + M + + + + + M M + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 3 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Hyperplasia, Focal | 4 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 3 1 2 2 1 2 1 1 |
Follicle, Cyst | 2 3 2 |
Follicular Cell, Hyperplasia | 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Cyst | 2 4 1 3 2 2 |
Hemorrhage | 2 |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hydrometra | 2 2 3 3 1 3 2 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 2 1 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + + + + + M + + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 2| 2| 5| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 4| 5|
| 2| 2| 8| 2| 2| 2| 7| 5| 5| 5| 2| 1| 2| 2| 9| 5| 2| 2| 2| 2| 2| 2| 2| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Depletion Cellular | 3 |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 3 3 3 2 |
Hyperplasia, Lymphoid | 2 2 |
Necrosis, Focal | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 |
Cyst | 2 |
Hemorrhage | |
Necrosis | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Dermis, Fibrosis | 2 |
Epidermis, Hyperplasia, Focal | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 2 2 1 2 2 1 1|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Hemorrhage | 1 |
__________________________________________________________________________|
Peripheral Nerve | +|
__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 2| 2| 5| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 4| 5|
| 2| 2| 8| 2| 2| 2| 7| 5| 5| 5| 2| 1| 2| 2| 9| 5| 2| 2| 2| 2| 2| 2| 2| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
75 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy | 1 1 1 1 1 1 2 1 1 3 |
Renal Tubule, Degeneration | 1 1|
Renal Tubule, Mineralization | 2|
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 8| 2| 2| 3| 9| 3| 0| 2| 8| 6| 2| 3| 2| 6| 3| 0| 3| 3| 3| 1| 3| 3| 3| 2| 2| |
| 7| 6| 5| 2| 4| 2| 4| 5| 7| 7| 5| 2| 6| 9| 2| 5| 2| 1| 1| 9| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
75 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + A + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + A + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + A + + + A A + + + A + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + A + + + A A + + + A + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + A + + + A A + + + A + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 | 1 3.0|
Eosinophilic Focus | 3 2 2| 3 2.3|
Hyperplasia, Focal, Lymphoid | | 1 2.0|
Inflammation, Chronic | 2 1 | 2 1.5|
Inflammation, Focal | | 1 2.0|
Mixed Cell Focus | 3 4 | 2 3.5|
Necrosis, Focal | | 1 1.0|
Vacuolization Cytoplasmic | 1 2 | 2 1.5|
Centrilobular, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + +| 5 |
Fat, Necrosis | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 | 5 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 1 1.0|
Mineralization | 1 2 2 1 1 | 9 1.4|
Glands, Degeneration, Cystic, Focal | 1 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 8| 2| 2| 3| 9| 3| 0| 2| 8| 6| 2| 3| 2| 6| 3| 0| 3| 3| 3| 1| 3| 3| 3| 2| 2| |
| 7| 6| 5| 2| 4| 2| 4| 5| 7| 7| 5| 2| 6| 9| 2| 5| 2| 1| 1| 9| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
75 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | | 2 1.5|
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 45 |
Cyst | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + I + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 2| 2 2.0|
Pars Distalis, Hyperplasia, Focal | 4 | 6 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 2 2 1 2 2 2 | 15 1.7|
Follicle, Cyst | 2 3 2 2 | 7 2.3|
Follicular Cell, Hyperplasia | 1 2 2 2 4 2| 11 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 3| 6 2.2|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst | 2 2 3 | 9 2.3|
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Hydrometra | 2 2 2 3 3 3 | 13 2.4|
Inflammation, Suppurative | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 2 2 2 2 3 2 3 3 2 2 2 2 2 1 2| 40 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 8| 2| 2| 3| 9| 3| 0| 2| 8| 6| 2| 3| 2| 6| 3| 0| 3| 3| 3| 1| 3| 3| 3| 2| 2| |
| 7| 6| 5| 2| 4| 2| 4| 5| 7| 7| 5| 2| 6| 9| 2| 5| 2| 1| 1| 9| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
75 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | | 1 3.0|
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + M + + + + M| 43 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + M + M| 45 |
Atrophy | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Depletion Cellular | 2 | 2 2.5|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 2 2 3 3 3 2 | 12 2.5|
Hyperplasia, Lymphoid | 3 3 | 4 2.5|
Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + M + M + M +| 47 |
Atrophy | | 2 3.0|
Cyst | 2 | 2 2.0|
Hemorrhage | 3 | 1 3.0|
Necrosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Ectasia | 2 | 1 2.0|
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 1 | 2 1.5|
Dermis, Fibrosis | 2 3 | 3 2.3|
Epidermis, Hyperplasia, Focal | 3 | 1 3.0|
Subcutaneous Tissue, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 2 1 2 2 2 2 2 | 17 1.8|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 8| 2| 2| 3| 9| 3| 0| 2| 8| 6| 2| 3| 2| 6| 3| 0| 3| 3| 3| 1| 3| 3| 3| 2| 2| |
| 7| 6| 5| 2| 4| 2| 4| 5| 7| 7| 5| 2| 6| 9| 2| 5| 2| 1| 1| 9| 1| 1| 1| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
75 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 2 2.5|
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Glands, Dilatation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 25 1.2|
Renal Tubule, Degeneration | 1 2 | 4 1.3|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 0| 7| 3| 3| 0| 3| 3| 3| 1| 3|
| 0| 0| 5| 0| 4| 0| 0| 8| 0| 0| 5| 0| 7| 0| 0| 5| 6| 0| 0| 3| 0| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + M M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 1 |
Eosinophilic Focus | 2 2 2 |
Inflammation, Chronic | 2 2 2 2 3 1 2 2 2 1 3 3 2 3|
Necrosis, Focal | 1 3 1 1 |
Vacuolization Cytoplasmic | 3 2 2 2 3 |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Karyomegaly | 2 2 3 3 2 2 3 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Hemorrhage | 3 3 |
Inflammation, Chronic | 3 |
Thrombosis | 3 |
Artery, Inflammation, Chronic | 3 3|
Artery, Thrombosis | 3 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 |
Artery, Hypertrophy | 3 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Ulcer | |
Epithelium, Hyperplasia | 2 3 3 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Glands, Degeneration, Cystic, Focal | 2 2 |
__________________________________________________________________________|
Tooth | + + + + + |
Developmental Malformation | 2 2 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Thrombosis | 3 4 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 0| 7| 3| 3| 0| 3| 3| 3| 1| 3|
| 0| 0| 5| 0| 4| 0| 0| 8| 0| 0| 5| 0| 7| 0| 0| 5| 6| 0| 0| 3| 0| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cyst | 1 |
Cytoplasmic Alteration, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 1 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 1 1 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + M + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
Inflammation, Chronic | 3 |
Spermatocele | 2 |
__________________________________________________________________________|
Penis | |
Angiectasis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Degeneration, Cystic | 3 4 3 2 3 3 2 |
Inflammation, Chronic | 2 3 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 0| 7| 3| 3| 0| 3| 3| 3| 1| 3|
| 0| 0| 5| 0| 4| 0| 0| 8| 0| 0| 5| 0| 7| 0| 0| 5| 6| 0| 0| 3| 0| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 3 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M + M + + + + + + + + + + + M + + M + + +|
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 2 1 2 2 2 1 2 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 4 2 3 3 1 3 2 3 3 3 2 1 3|
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + M + M + + + + +|
Atrophy | |
Cyst | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 1 |
Hyperplasia, Histiocytic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 0| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 0| 7| 3| 3| 0| 3| 3| 3| 1| 3|
| 0| 0| 5| 0| 4| 0| 0| 8| 0| 0| 5| 0| 7| 0| 0| 5| 6| 0| 0| 3| 0| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 |
Nephropathy | 2 2 2 3 2 2 2 1 3 2 3 2 2 2 2 2 2 2 1 1 1 2|
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| |
| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + M + M + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | 2 | 2 1.5|
Eosinophilic Focus | 2 2 3 | 6 2.2|
Inflammation, Chronic | 2 2 2 3 2 3 2 2 3 2 | 24 2.2|
Necrosis, Focal | 1 | 5 1.4|
Vacuolization Cytoplasmic | 2 2 2 2 1 | 10 2.1|
Bile Duct, Hyperplasia | | 1 2.0|
Hepatocyte, Karyomegaly | 2 2 2 2 2 2 2 | 15 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 10 |
Hemorrhage | | 2 3.0|
Inflammation, Chronic | | 1 3.0|
Thrombosis | | 1 3.0|
Artery, Inflammation, Chronic | 3 | 3 3.0|
Artery, Thrombosis | | 1 3.0|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | | 1 3.0|
Artery, Hypertrophy | | 1 3.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 4 4 1 2 1 2 3 | 14 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Glands, Degeneration, Cystic, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + +| 10 |
Developmental Malformation | 2 3 3 3 3| 10 2.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| |
| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 2.0|
Thrombosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Cyst | | 1 1.0|
Cytoplasmic Alteration, Focal | 1 | 1 1.0|
Hypertrophy, Focal | 2 1 2 2 3 2 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 2.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | 1 1 | 2 1.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 2 1.0|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 2 | 6 1.3|
Follicle, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 2 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Spermatocele | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| |
| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 2 2 2 1 2 2 3 2 2 2 3 2 3 3 3| 23 2.4|
Inflammation, Chronic | 3 2 3 3 3 2| 10 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Mineralization, Focal | 2 | 1 2.0|
Germinal Epithelium, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | 3 | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node | + | 5 |
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M M M + + + + + + + + + +| 42 |
Hyperplasia, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 | 3 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 3 2 2 2 2 2 2 3| 17 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 1| 1 1.0|
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 2 3 2 2 2 | 20 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + M M + + +| 43 |
Atrophy | 3 3| 2 3.0|
Cyst | 1 2 1 2 | 6 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| |
| 0| 5| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 3 1.7|
Hyperplasia, Histiocytic | 1 3 | 4 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Cyst | 2 2 | 2 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Nephropathy | 2 2 2 2 2 1 3 1 2 2 1 2 2 2 2 2 2 1 1 1 2 2 3 2| 46 1.9|
__________________________________________________________________________|____________|
Urethra | +| 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 3| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 2| 3| 2| 3| 2| 3| 3| 2| 2| 2|
| 7| 5| 9| 2| 1| 7| 9| 2| 1| 9| 9| 9| 9| 1| 9| 9| 1| 5| 1| 5| 1| 1| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | 2 |
Clear Cell Focus | 2 1 |
Congestion | |
Eosinophilic Focus | 3 3 2 2 |
Hepatodiaphragmatic Nodule | 2 |
Inflammation, Chronic | 1 3 2 1 2 2 2 2 2 1 2 2|
Mixed Cell Focus | 2|
Necrosis, Focal | 2 3 3 |
Vacuolization Cytoplasmic | 1 1 2 1 2 2 2 2|
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Karyomegaly | 3 2 2 3|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | |
Artery, Inflammation, Chronic | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Acinus, Atrophy, Diffuse | 2 3 |
Duct, Cyst | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Ulcer | 2 |
Epithelium, Hyperplasia | 1 2 1 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Glands, Degeneration, Cystic, Focal | 2 2 2 2 |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 3| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 2| 3| 2| 3| 2| 3| 3| 2| 2| 2|
| 7| 5| 9| 2| 1| 7| 9| 2| 1| 9| 9| 9| 9| 1| 9| 9| 1| 5| 1| 5| 1| 1| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic, Focal | 2 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 2 2 |
Capsule, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Pars Distalis, Cyst | 1|
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 2 2 1 2 1 |
Follicle, Cyst | 3 3 2 2 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 3 3 2 3 2 3 2 2 2 2 2 2 2 2 3 2|
Inflammation, Chronic | 3 2 3 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 3| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 2| 3| 2| 3| 2| 3| 3| 2| 2| 2|
| 7| 5| 9| 2| 1| 7| 9| 2| 1| 9| 9| 9| 9| 1| 9| 9| 1| 5| 1| 5| 1| 1| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | 3 3 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hemorrhage | 2 2 2 2 2 1 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 3 3 3 2 2 2 3 2 3 2|
__________________________________________________________________________|
Thymus | M + + + + I + + + + + + M + + + + + M + + + I + +|
Atrophy | 3 3 3 2 |
Cyst | 1 2 1 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Fibrosis | 2 |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + +|
Inflammation, Chronic, Focal | 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 6| 3| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 2| 3| 2| 3| 2| 3| 3| 2| 2| 2|
| 7| 5| 9| 2| 1| 7| 9| 2| 1| 9| 9| 9| 9| 1| 9| 9| 1| 5| 1| 5| 1| 1| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Metaplasia, Focal, Osseous | |
Nephropathy | 2 2 2 1 2 1 1 3 2 2 4 2 1 1 1 1 2 1 2 2 2 2 1|
__________________________________________________________________________|
Urethra | |
Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| |
DAY ON TEST | 2| 9| 3| 3| 3| 1| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 3| 3| 2| 2| 2| 1| 0| 6| 3| |
| 9| 8| 1| 1| 1| 1| 5| 9| 9| 9| 9| 1| 9| 1| 9| 4| 1| 3| 9| 1| 5| 1| 6| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
15 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + + + + + + + M + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + A + M + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + A + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + A + + + + + + +| 48 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.0|
Basophilic Focus | | 1 2.0|
Clear Cell Focus | | 2 1.5|
Congestion | 4 | 1 4.0|
Eosinophilic Focus | 2 2 | 6 2.3|
Hepatodiaphragmatic Nodule | | 1 2.0|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 3 2 | 25 2.0|
Mixed Cell Focus | | 1 2.0|
Necrosis, Focal | 2 3 1 | 6 2.3|
Vacuolization Cytoplasmic | 2 2 2 | 11 1.7|
Bile Duct, Hyperplasia | 1 | 2 2.0|
Hepatocyte, Karyomegaly | 2 3 2 2 2 3 2 3 2 3 | 14 2.4|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Inflammation, Chronic | 2 | 1 2.0|
Artery, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 3.0|
Acinus, Atrophy, Diffuse | | 2 2.5|
Duct, Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 3 2.0|
Ulcer | 2 3 | 3 2.3|
Epithelium, Hyperplasia | 2 3 2 2 3 | 12 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 1 1 1 | 4 1.0|
Glands, Degeneration, Cystic, Focal | 1 2 2 | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| |
DAY ON TEST | 2| 9| 3| 3| 3| 1| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 3| 3| 2| 2| 2| 1| 0| 6| 3| |
| 9| 8| 1| 1| 1| 1| 5| 9| 9| 9| 9| 1| 9| 1| 9| 4| 1| 3| 9| 1| 5| 1| 6| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
15 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + | 5 |
Developmental Malformation | 3 3 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Cytoplasmic Alteration, Focal | | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 4 2 2 1 | 7 2.1|
Capsule, Hyperplasia, Focal | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Pars Distalis, Cyst | 2 | 2 1.5|
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 1 1 1 2| 11 1.5|
Follicle, Cyst | 2 | 6 2.2|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + M + + + + + I + + + + + + + + + + + + +| 48 |
Degeneration, Cystic | 3 2 3 2 3 3 2 2 2 3 3 2 3| 31 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| |
DAY ON TEST | 2| 9| 3| 3| 3| 1| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 3| 3| 2| 2| 2| 1| 0| 6| 3| |
| 9| 8| 1| 1| 1| 1| 5| 9| 9| 9| 9| 1| 9| 1| 9| 4| 1| 3| 9| 1| 5| 1| 6| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
15 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 3 3 3 3 | 8 2.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Inguinal, Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 2 3.0|
Renal, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + M + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + A + + + + + + + + + M + + + M + + + + +| 46 |
Hemorrhage | 2 2 2 1 2 3 | 13 1.9|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 1 2 2 2 2 2 2 2 2 3 2 3 3 | 27 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + A + + I + + + + + + + + + + + + + + + M| 42 |
Atrophy | 3 3 | 6 2.8|
Cyst | 2 1 | 6 1.3|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dermis, Fibrosis | | 1 2.0|
Subcutaneous Tissue, Edema | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| |
DAY ON TEST | 2| 9| 3| 3| 3| 1| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 3| 3| 2| 2| 2| 1| 0| 6| 3| |
| 9| 8| 1| 1| 1| 1| 5| 9| 9| 9| 9| 1| 9| 1| 9| 4| 1| 3| 9| 1| 5| 1| 6| 4| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
15 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Foreign Body | 2 | 1 2.0|
Hemorrhage | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3| 1 3.0|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
Nephropathy | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 3 1 2 1 1 1 1 3| 46 1.8|
__________________________________________________________________________|____________|
Urethra | + + + | 3 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 2| 5| 2| 2| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 5| 9| 6| 9| 9| 0| 0| 0| 1| 1| 9| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 1 1 |
Eosinophilic Focus | 3 2 3 2 3 3 |
Inflammation, Chronic | 2 3 1 3 2 2 2 2 2 |
Necrosis, Focal | 3 1 3 |
Vacuolization Cytoplasmic | 2 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Hypertrophy | |
Hepatocyte, Karyomegaly | 3 2 3 3 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + M + +|
Acinus, Atrophy, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | 2 2 1 2 2 2 2 2 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hyperplasia | 2 |
Mineralization | |
Glands, Degeneration, Cystic, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 2| 5| 2| 2| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 5| 9| 6| 9| 9| 0| 0| 0| 1| 1| 9| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 1 1 |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 1 1 2 2 1 |
Follicle, Cyst | 1 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 2 2 2 3 2 2 2 2 2 2 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + M + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 2 2 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 3 3 2 2 3 2|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + M + M +|
Atrophy | 3 |
Cyst | 1 2 2 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 2| 5| 2| 2| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2|
| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 5| 9| 6| 9| 9| 0| 0| 0| 1| 1| 9| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Epidermis, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 2 |
Inflammation, Suppurative | |
Metaplasia, Focal, Osseous | 2 1 |
Nephropathy | 3 1 2 1 2 2 1 2 2 1 2 1 2 2 2 1 2 1 2 2 2 1 1 2|
Papilla, Necrosis | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 6| 2| 2| 2| 0| 3| 3| 7| 3| 2| 2| 2| 2| 3| 3| 7| 2| 3| 3| |
| 1| 1| 1| 1| 0| 9| 8| 9| 9| 9| 0| 1| 1| 7| 1| 9| 9| 9| 9| 1| 1| 2| 5| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + A + + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + A + + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | 3 | 3 1.7|
Eosinophilic Focus | 2 3 3 | 9 2.7|
Inflammation, Chronic | 2 2 2 2 3 2 2 | 16 2.1|
Necrosis, Focal | | 3 2.3|
Vacuolization Cytoplasmic | 1 2 2 2 | 6 1.8|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 | 2 2.0|
Hepatocyte, Hypertrophy | 3 | 1 3.0|
Hepatocyte, Karyomegaly | 2 2 2 2 2 3 | 12 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
Epithelium, Hyperplasia | 1 2 2 1 2 2 | 16 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
Mineralization | 2 2 1 | 3 1.7|
Glands, Degeneration, Cystic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 6| 2| 2| 2| 0| 3| 3| 7| 3| 2| 2| 2| 2| 3| 3| 7| 2| 3| 3| |
| 1| 1| 1| 1| 0| 9| 8| 9| 9| 9| 0| 1| 1| 7| 1| 9| 9| 9| 9| 1| 1| 2| 5| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cytoplasmic Alteration, Focal | 2 2 | 2 2.0|
Hyperplasia, Focal | 2 | 2 2.0|
Hypertrophy, Focal | 2 2 2 1 2 1 1 | 9 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | | 3 1.0|
Pars Distalis, Hyperplasia, Focal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 1 2 | 10 1.5|
Follicle, Cyst | 3 | 3 2.0|
Follicular Cell, Hyperplasia | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 3 3 2 3 2 3 3 2 2 2 3 2 2 2 2| 31 2.3|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 1 3.0|
Hemorrhage | 1 2 1 2 2 3 | 9 1.8|
Hyperplasia, Lymphoid | 3 | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 6| 2| 2| 2| 0| 3| 3| 7| 3| 2| 2| 2| 2| 3| 3| 7| 2| 3| 3| |
| 1| 1| 1| 1| 0| 9| 8| 9| 9| 9| 0| 1| 1| 7| 1| 9| 9| 9| 9| 1| 1| 2| 5| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 1 2 3 3 2 3| 25 2.2|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + M + + + + M| 44 |
Atrophy | 1 3 3 | 4 2.5|
Cyst | 2 | 5 1.6|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Histiocytic | 2 3 3 | 4 2.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Infarct | 1 | 2 1.5|
Inflammation, Suppurative | 4 | 1 4.0|
Metaplasia, Focal, Osseous | | 2 1.5|
Nephropathy | 1 1 2 2 1 1 1 2 2 1 2 2 2 2 1 1 2 1 2 1 3| 45 1.6|
Papilla, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 2| 2| 6| 2| 2| 2| 0| 3| 3| 7| 3| 2| 2| 2| 2| 3| 3| 7| 2| 3| 3| |
| 1| 1| 1| 1| 0| 9| 8| 9| 9| 9| 0| 1| 1| 7| 1| 9| 9| 9| 9| 1| 1| 2| 5| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
50 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 0| 3| 4| 7| 7| 0| 1| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 4| 7| 7| 2| 7| 4| 4|
DAY ON TEST | 2| 1| 8| 4| 2| 3| 3| 8| 3| 3| 2| 2| 8| 3| 2| 2| 2| 2| 0| 2| 2| 1| 2| 0| 4|
| 9| 6| 2| 2| 6| 0| 2| 4| 0| 0| 9| 5| 1| 4| 9| 9| 9| 9| 7| 9| 9| 1| 5| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A A + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A A + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + A + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A A A + + + A + + + + A + + + + + A + + + + + +|
Necrosis, Focal | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + + A + + + + A + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + A A A + + + A + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3|
Inflammation, Chronic | 2 2 |
Mineralization, Focal | |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic | 2 |
Hepatocyte, Hypertrophy | 2 |
Hepatocyte, Karyomegaly | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + A + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 3 3 2 1 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + A A + + + + + + + + + A + + + + + + + + + + A +|
Edema | |
Erosion | 3 |
Mineralization | 2 |
Glands, Degeneration, Cystic, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hypertrophy, Focal | 2 2 1 2 |
Capsule, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + M + + + + I +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 0| 3| 4| 7| 7| 0| 1| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 4| 7| 7| 2| 7| 4| 4|
DAY ON TEST | 2| 1| 8| 4| 2| 3| 3| 8| 3| 3| 2| 2| 8| 3| 2| 2| 2| 2| 0| 2| 2| 1| 2| 0| 4|
| 9| 6| 2| 2| 6| 0| 2| 4| 0| 0| 9| 5| 1| 4| 9| 9| 9| 9| 7| 9| 9| 1| 5| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 1 1 1 2 |
Follicle, Cyst | 2 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 2 3 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Germinal Epithelium, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
__________________________________________________________________________|
Lymph Node | + + + |
Bronchial, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Inguinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | 2 1 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A +|
Depletion Cellular | 2 3 3 3 |
Hematopoietic Cell Proliferation | 1 3 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M M + + + + + + + + + + + + +|
Atrophy | 3 2 |
Cyst | 1 2 |
Necrosis | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
_____________________________________________________________________________________________________________________
| 7| 0| 3| 4| 7| 7| 0| 1| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 4| 7| 7| 2| 7| 4| 4|
DAY ON TEST | 2| 1| 8| 4| 2| 3| 3| 8| 3| 3| 2| 2| 8| 3| 2| 2| 2| 2| 0| 2| 2| 1| 2| 0| 4|
| 9| 6| 2| 2| 6| 0| 2| 4| 0| 0| 9| 5| 1| 4| 9| 9| 9| 9| 7| 9| 9| 1| 5| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 4 3 |
Hemorrhage | 2 |
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | |
Infarct | 3 |
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 1 1 1 2 2 2 2 2 2 1 1 1 2 1 1 |
Renal Tubule, Degeneration | 2 2 |
Renal Tubule, Dilatation | 2 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 2| 7| 7| 3| 7| 7| 7| 7| 3| 7| 7| 7| 3| 3| 6| 6| 1| 2| 0| 7| 5| 7| |
DAY ON TEST | 3| 2| 2| 1| 2| 2| 5| 2| 2| 2| 2| 5| 0| 3| 3| 5| 3| 3| 3| 2| 8| 9| 3| 9| 2| |
| 1| 9| 9| 2| 9| 6| 2| 9| 6| 9| 5| 9| 3| 0| 0| 9| 2| 6| 6| 1| 2| 5| 0| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + + + + M + + + A A M + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A A A + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A A + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + A A A + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A A A + + + + + +| 41 |
Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + A A A + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A + + + + + + + + + + + + A A A + + + + + +| 38 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 3.0|
Inflammation, Chronic | 1 | 3 1.7|
Mineralization, Focal | 2 | 1 2.0|
Necrosis, Focal | 1 | 2 1.5|
Vacuolization Cytoplasmic | | 1 2.0|
Hepatocyte, Hypertrophy | | 1 2.0|
Hepatocyte, Karyomegaly | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 2 1 1 2 1 2 | 13 1.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A A A + + + + + +| 43 |
Edema | 3 | 1 3.0|
Erosion | | 1 3.0|
Mineralization | | 1 2.0|
Glands, Degeneration, Cystic, Focal | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypertrophy, Focal | 2 2 1| 7 1.7|
Capsule, Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 2| 7| 7| 3| 7| 7| 7| 7| 3| 7| 7| 7| 3| 3| 6| 6| 1| 2| 0| 7| 5| 7| |
DAY ON TEST | 3| 2| 2| 1| 2| 2| 5| 2| 2| 2| 2| 5| 0| 3| 3| 5| 3| 3| 3| 2| 8| 9| 3| 9| 2| |
| 1| 9| 9| 2| 9| 6| 2| 9| 6| 9| 5| 9| 3| 0| 0| 9| 2| 6| 6| 1| 2| 5| 0| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + M + + + + M + + + + + M| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + + + + + + + + + + + I + + + M + + + + + + +| 44 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 2 1 1 1 1 1 2| 13 1.3|
Follicle, Cyst | | 2 2.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 3 3 2 2 | 12 2.3|
Inflammation, Chronic | 3 3 3| 3 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Focal | 2 | 1 2.0|
Germinal Epithelium, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Depletion Cellular | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Bronchial, Hyperplasia, Lymphoid | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + M + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | | 2 2.5|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + I + + + + + + + + + + + +| 48 |
Atrophy | 2 2 | 2 2.0|
Hemorrhage | 2 2 2 2 | 6 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 2| 7| 7| 3| 7| 7| 7| 7| 3| 7| 7| 7| 3| 3| 6| 6| 1| 2| 0| 7| 5| 7| |
DAY ON TEST | 3| 2| 2| 1| 2| 2| 5| 2| 2| 2| 2| 5| 0| 3| 3| 5| 3| 3| 3| 2| 8| 9| 3| 9| 2| |
| 1| 9| 9| 2| 9| 6| 2| 9| 6| 9| 5| 9| 3| 0| 0| 9| 2| 6| 6| 1| 2| 5| 0| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Cellular | 3 3 2 3 1 2 3 3 | 12 2.6|
Hematopoietic Cell Proliferation | 2 2 2 1 2 1 2 | 13 1.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + I + + + + + + + M + + + + + + +| 46 |
Atrophy | 2 3 3 | 5 2.6|
Cyst | 1 | 3 1.3|
Necrosis | 1 2 3 4 3 2 4 | 11 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 4 3.3|
Hemorrhage | | 1 2.0|
Hyperplasia, Histiocytic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Cyst | 1 2| 2 1.5|
Infarct | 2 | 2 2.5|
Metaplasia, Focal, Osseous | | 1 2.0|
Nephropathy | 2 1 2 2 1 2 1 1 3 1 2 2 1 1| 29 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05067-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC THEOPHYLLINE Date: 07/03/96
Route: GAVAGE Time: 12:33:32
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 2| 7| 7| 3| 7| 7| 7| 7| 3| 7| 7| 7| 3| 3| 6| 6| 1| 2| 0| 7| 5| 7| |
DAY ON TEST | 3| 2| 2| 1| 2| 2| 5| 2| 2| 2| 2| 5| 0| 3| 3| 5| 3| 3| 3| 2| 8| 9| 3| 9| 2| |
| 1| 9| 9| 2| 9| 6| 2| 9| 6| 9| 5| 9| 3| 0| 0| 9| 2| 6| 6| 1| 2| 5| 0| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
150 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Degeneration | 1 2 2 2 1 | 7 1.7|
Renal Tubule, Dilatation | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
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---------- END OF REPORT ----------
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