TDMS Study 05068-09 Pathology Tables
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
CORE ANIMALS
Facility: Microbiological Associates
Chemical CAS #: 76-57-3
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|
DAY ON TEST | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|
| 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + + + + + + + M + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|
DAY ON TEST | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|
| 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + M + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + M +|
Adenoma | X X X |
Carcinoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Malignant | X |
Leukemia Mononuclear | X X X X X X |
Luteoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Axillary, Leukemia Mononuclear | X |
Bronchial, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X |
Mediastinal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|
DAY ON TEST | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|
| 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + M + + + M|
Leukemia Mononuclear | X X X X X |
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X |
Leukemia Mononuclear | X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Benign | X |
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|
DAY ON TEST | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|
| 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9| |
| 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 14 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
__________________________________________________________________________|____________|
Oral Mucosa | + + + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 11 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 7 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9| |
| 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 45 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 |
Leukemia Mononuclear | X X | 6 |
Pars Distalis, Adenoma | X X X X X X X X X X| 16 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Adenoma | | 4 |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
Adenoma | X X | 5 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa-Theca Tumor Malignant | | 1 |
Leukemia Mononuclear | X X X | 9 |
Luteoma | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 10 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
Axillary, Leukemia Mononuclear | | 1 |
Bronchial, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9| |
| 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Leukemia Mononuclear | | 3 |
Mediastinal, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X | 11 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 14 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + M + + + + + + + + + + + + + + +| 44 |
Leukemia Mononuclear | X | 6 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X X| 3 |
Fibroadenoma | X X X X X X X X X X | 22 |
Fibroadenoma, Multiple | X X | 5 |
Leukemia Mononuclear | | 2 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Fibroma | X X | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Benign | | 1 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9| |
| 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X | 13 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 11 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 14 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | |
Fat, Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M M M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Adenoma | X X |
Leukemia Mononuclear | X |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Polyp Stromal | X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Bronchial, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Leukemia Mononuclear | X |
Subcutaneous Tissue, Fibroma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spinal Cord | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Chordoma, Metastatic, Uncertain | |
Primary Site | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Lipoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| |
| 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
400 PPM | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 16 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Leukemia Mononuclear | X | 1 |
Fat, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Zymbal's Gland| X | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| |
| 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
400 PPM | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 8 |
Pheochromocytoma Benign | X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M + + M + + M + M M + + + + M + + + M + +| 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 9 |
Pars Distalis, Adenoma | X X X X X X X| 17 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Adenoma | X | 3 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + M + + + + +| 47 |
Adenoma | X X X| 5 |
Leukemia Mononuclear | X | 2 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 5 |
Polyp Stromal | X X | 6 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 15 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
Bronchial, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X | 6 |
Pancreatic, Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Zymbal's Gland| X | 1 |
Leukemia Mononuclear | X X X X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| |
| 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
400 PPM | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 16 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + M + + + + + + +| 46 |
Leukemia Mononuclear | X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X | 2 |
Fibroadenoma | X X X X X X X X X| 20 |
Fibroadenoma, Multiple | | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X | 1 |
Leukemia Mononuclear | | 1 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Chordoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Leukemia Mononuclear | X X X X X | 14 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Zymbal's Gland| X | 1 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| |
| 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
400 PPM | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 14 |
Lipoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|
| 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|
| 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + M + + + + + + + + + + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Leukemia Mononuclear | X X |
Bilateral, Adenoma | X|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Oviduct | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Polyp Stromal | X X X X |
Sarcoma | |
Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|
| 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Adenocarcinoma | X X |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | X X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Sarcoma | X |
Tail, Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Nasolacrimal Duct, Squamous Cell | |
Carcinoma | X|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Schwannoma Malignant | X |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|
| 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + + |
Carcinoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Nephroblastoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|
| 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|
| 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
C-Cell, Adenoma | X X |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Adenoma | X X X X X X X |
Leukemia Mononuclear | |
Bilateral, Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Oviduct | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Polyp Stromal | X X |
Sarcoma | X |
Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|
| 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + M + + + + + + + + + + M +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X |
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Subcutaneous Tissue, Fibroma | X X|
Subcutaneous Tissue, Sarcoma | |
Tail, Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Nasolacrimal Duct, Squamous Cell | |
Carcinoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Schwannoma Malignant | X |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|
| 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
Nephroblastoma | |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
Leukemia Mononuclear | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 18 |
__________________________________________________________________________|____________|
Mesentery | | 6 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
Aorta, Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Heart | + | 51 |
Leukemia Mononuclear | X | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Adenoma | | 1 |
Leukemia Mononuclear | X | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 50 |
Leukemia Mononuclear | | 9 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 50 |
Leukemia Mononuclear | X | 10 |
Pars Distalis, Adenoma | | 19 |
Pars Distalis, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 5 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 50 |
Adenoma | X | 11 |
Leukemia Mononuclear | X | 3 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + | 51 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Leukemia Mononuclear | X | 4 |
Polyp Stromal | | 6 |
Sarcoma | | 1 |
Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 2 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 13 |
__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Leukemia Mononuclear | X | 4 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Leukemia Mononuclear | X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 49 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 18 |
__________________________________________________________________________|____________|
Thymus | + | 47 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 50 |
Adenocarcinoma | | 3 |
Fibroadenoma | X | 21 |
Fibroadenoma, Multiple | | 6 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Skin | + | 50 |
Leukemia Mononuclear | | 1 |
Subcutaneous Tissue, Fibroma | | 3 |
Subcutaneous Tissue, Sarcoma | | 1 |
Tail, Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Leukemia Mononuclear | X | 16 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | + | 51 |
Leukemia Mononuclear | X | 5 |
Nasolacrimal Duct, Squamous Cell | | |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + | 51 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Pinna, Schwannoma Malignant | | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
Carcinoma | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Leukemia Mononuclear | X | 12 |
Nephroblastoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|
| 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oral Mucosa | |
Buccal, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|
| 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Follicular Cell, Carcinoma| |
C-Cell, Adenoma | X X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X X X |
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | |
Fibroadenoma | X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|
| 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Sarcoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|
| 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + A A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Oral Mucosa | + |
Buccal, Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + M M M + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|
| 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Follicular Cell, Carcinoma| X |
C-Cell, Adenoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + M + + + M +|
Leukemia Mononuclear | X X |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | X |
Fibroadenoma | X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|
| 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Sarcoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 47 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Buccal, Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
Aorta, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Heart | + | 51 |
Leukemia Mononuclear | | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Leukemia Mononuclear | | 8 |
Pars Distalis, Adenoma | | 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Leukemia Mononuclear | | 1 |
Bilateral, Follicular Cell, Carcinoma| | 1 |
C-Cell, Adenoma | | 3 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 51 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + | 51 |
Leukemia Mononuclear | | 8 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Leukemia Mononuclear | | 3 |
Polyp Stromal | | 3 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Lymph Node | | 11 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 5 |
Pancreatic, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M | 46 |
Leukemia Mononuclear | | 7 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Adenoacanthoma | | 1 |
Fibroadenoma | | 6 |
Fibroadenoma, Multiple | | 2 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Subcutaneous Tissue, Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Nose | + | 51 |
Leukemia Mononuclear | | 4 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + | 51 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 9 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Leukemia Mononuclear | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|
| 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Polyp Adenomatous, Multiple | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + A +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + A + + + + + + A +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + A + + + + A +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + + + + |
Leukemia Mononuclear | |
Fat, Leukemia Mononuclear | X |
Fat, Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|
| 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Pheochromocytoma Malignant | X |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M M + M M M + + M + + M +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|
| 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X X X |
Pancreatic, Leukemia Mononuclear | X X|
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + M + + + + M +|
Fibroadenoma | X|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Leukemia Mononuclear | X X X X X |
Lip, Basosquamous Tumor Benign | |
Subcutaneous Tissue, Fibroma | X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Meningioma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|
| 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 6 |
Polyp Adenomatous, Multiple | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X | 1 |
Hepatocellular Adenoma, Multiple | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| 32 |
__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Leukemia Mononuclear | X | 1 |
Fat, Leukemia Mononuclear | X | 2 |
Fat, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 13 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Aorta, Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 23 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 26 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X | 23 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Complex | X | 1 |
Pheochromocytoma Benign | X X X X X X X | 13 |
Bilateral, Pheochromocytoma Benign | X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + + M + + M + + + + + + + + + +| 38 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 23 |
Pars Distalis, Adenoma | X X X X X | 9 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 6 |
C-Cell, Adenoma | X X X | 3 |
C-Cell, Carcinoma | X | 2 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 12 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 3 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 16 |
Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X| 38 |
Interstitial Cell, Adenoma | X X X X | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 27 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 20 |
Iliac, Leukemia Mononuclear | X | 2 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X X | 14 |
Pancreatic, Leukemia Mononuclear | X X X | 5 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 23 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| 32 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + + + M + + +| 46 |
Leukemia Mononuclear | X X X X X X X X X | 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibroadenoma | | 1 |
Leukemia Mononuclear | X X X X X | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | | 1 |
Leukemia Mononuclear | X X X | 8 |
Lip, Basosquamous Tumor Benign | X | 1 |
Subcutaneous Tissue, Fibroma | X | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 13 |
Meningioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 28 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 15 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 28 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X| 32 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|
| 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Fat, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Pheochromocytoma Benign | X X X X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|
| 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Pars Distalis, Adenoma | X X |
Pars Distalis, Leukemia Mononuclear | |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Leukemia Mononuclear | X |
Bronchial, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X X |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|
| 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + M + M + M + + + + + + + M + + + + + + M|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X X |
Leukemia Mononuclear | X |
Lipoma | X |
Foot, Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X |
Schwannoma Malignant, Metastatic, Ear| |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|
| 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Adenoma | X |
Chondroma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Leukemia Mononuclear | |
Pinna, Schwannoma Malignant | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A A + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A A + + + + + + + + + + + +| 48 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X | 5 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + A A + + A + + + + + + + + +| 46 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X| 27 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 21 |
Leukemia Mononuclear | | 2 |
Fat, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 11 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X| 19 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 20 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 21 |
Pheochromocytoma Benign | X X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + M + + + + + + + + M + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 20 |
Pars Distalis, Adenoma | X X | 4 |
Pars Distalis, Leukemia Mononuclear | X| 1 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X X | 3 |
C-Cell, Carcinoma | X | 2 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X | 6 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 10 |
Mesothelioma Malignant | X | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X | 39 |
Interstitial Cell, Adenoma | X X X X X| 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 24 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 17 |
Axillary, Leukemia Mononuclear | X X | 3 |
Bronchial, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 3 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X | 11 |
Pancreatic, Leukemia Mononuclear | X X | 4 |
Renal, Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 14 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X| 27 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + M + + + M + + M + + + +| 41 |
Leukemia Mononuclear | X X X X X X | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | | 2 |
Leukemia Mononuclear | X | 2 |
Lipoma | | 1 |
Foot, Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | X X | 2 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Thoracic, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 25 |
Schwannoma Malignant, Metastatic, Ear| X | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
Chondroma | | 1 |
Leukemia Mononuclear | X X X X X X X | 9 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Leukemia Mononuclear | X | 1 |
Pinna, Schwannoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 19 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X | 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X| 27 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Adenocarcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Malignant| |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + M M + + M + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Penis | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + M + + +|
Adenoma | X X |
Carcinoma | X |
Leukemia Mononuclear | X X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | X |
Bronchial, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X X X X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + M + + + + M + + + + + + + + M + + + M + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Squamous Cell Carcinoma | X |
Trichoepithelioma | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Back, Lipoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
Schwannoma Malignant, Metastatic, Ear| |
Mediastinum, Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Schwannoma Malignant | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + + + + + + + +| 47 |
Adenocarcinoma | X | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 36 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 17 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | X | 1 |
Fat, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 23 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 22 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X| 15 |
Pheochromocytoma Benign | X X X X| 5 |
Bilateral, Pheochromocytoma Malignant| X | 1 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + + + + + + + + + + + + + + + + + + + +| 42 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X| 19 |
Pars Distalis, Adenoma | X X X X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
C-Cell, Adenoma | X | 2 |
C-Cell, Carcinoma | X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Leukemia Mononuclear | X X X X | 9 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X X X | 5 |
Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X X| 8 |
Bilateral, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 7 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X| 46 |
Interstitial Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 30 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + +| 14 |
Leukemia Mononuclear | X | 1 |
Axillary, Leukemia Mononuclear | | 1 |
Bronchial, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X| 9 |
Pancreatic, Leukemia Mononuclear | X X X | 3 |
Renal, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 15 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 36 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + M + M + + + + + + + M + + + + M| 41 |
Leukemia Mononuclear | X X X X X X X X | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroadenoma | X | 1 |
Leukemia Mononuclear | X X X X X X X| 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X X | 2 |
Squamous Cell Carcinoma | | 1 |
Trichoepithelioma | X | 1 |
Subcutaneous Tissue, Fibroma | X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Back, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 30 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | X | 1 |
Schwannoma Malignant, Metastatic, Ear| X | 1 |
Mediastinum, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Schwannoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 26 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 36 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|
| 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1600 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
PPM | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | |
Sarcoma | |
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|
| 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1600 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
PPM | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Leukemia Mononuclear | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + M + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + M + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|
| 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1600 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
PPM | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Bronchial, Leukemia Mononuclear | X X |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X X |
Lumbar, Leukemia Mononuclear | X|
Mediastinal, Leukemia Mononuclear | X X X X X X X|
Mediastinal, Sarcoma, Metastatic, | |
Mesentery | |
Pancreatic, Leukemia Mononuclear | X X X|
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Thymus | M + + + + M + + + + M + + + + + + + + M + + M + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Fibroadenoma | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Leukemia Mononuclear | X |
Subcutaneous Tissue, Fibroma | |
Tail, Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|
| 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1600 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
PPM | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rib, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Sarcoma, Metastatic, | |
Mesentery | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spinal Cord | + |
Hemangioma | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Sarcoma, Metastatic, Mesentery | |
Schwannoma Malignant, Metastatic, Ear| X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Schwannoma Malignant | |
Pinna, Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 8 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 8 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 5 |
Mesothelioma Malignant | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + + + +| 46 |
Leukemia Mononuclear | X X | 6 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X | 2 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 37 |
Mesothelioma Malignant | X X | 2 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 17 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X | 1 |
Sarcoma | X | 1 |
Fat, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 17 |
Mesothelioma Malignant | X X | 2 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mesothelioma Malignant | X X | 2 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 11 |
Mesothelioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 27 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 30 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X| 24 |
Pheochromocytoma Benign | X X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M M + + + + + + +| 46 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X X| 18 |
Pars Distalis, Adenoma | X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 7 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 4 |
Mesothelioma Malignant | X X | 2 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 14 |
Mesothelioma Malignant | X X | 3 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X| 47 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 28 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 22 |
Axillary, Leukemia Mononuclear | X X X | 3 |
Bronchial, Leukemia Mononuclear | | 2 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 3 |
Lumbar, Leukemia Mononuclear | X X | 3 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X| 15 |
Mediastinal, Sarcoma, Metastatic, | | |
Mesentery | X | 1 |
Pancreatic, Leukemia Mononuclear | X X | 5 |
Renal, Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X| 24 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 16 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 37 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + + M + + + + M + + + + + +| 41 |
Leukemia Mononuclear | X X X X X X X X X| 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Fibroadenoma | | 1 |
Leukemia Mononuclear | X X X X | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X | 2 |
Leukemia Mononuclear | X | 2 |
Subcutaneous Tissue, Fibroma | X | 1 |
Tail, Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Rib, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Abdominal, Sarcoma, Metastatic, | | |
Mesentery | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X X X X X X X X| 13 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Hemangioma | | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 29 |
Sarcoma, Metastatic, Mesentery | X | 1 |
Schwannoma Malignant, Metastatic, Ear| X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05068-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CODEINE Date: 03/19/97
Route: DOSED FEED Time: 17:19:42
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Schwannoma Malignant | X | 1 |
Pinna, Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 27 |
Mesothelioma Malignant | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X | 18 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 37 |
Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
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