TDMS Study 05068-10 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
CODEINE
NTP Experiment-Test: 05068-10 Report: PEIRPT09
Study Type: CHRONIC Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
CORE STUDY
Facility: Microbiological Associates
Chemical CAS #: 76-57-3
Lock Date: 03/03/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25023 Missing
25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3|
| 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + M + + + M + + + M + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Eosinophilic Focus | 3 X X X |
Hematopoietic Cell Proliferation | 3 2 |
Inflammation, Chronic Active | 1 2 4 1 |
Necrosis | 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic Active | 3 2 |
Fat, Necrosis | 4 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 |
Acinar Cell, Atrophy | 2 4 |
Acinar Cell, Depletion Secretory | |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 3|
Inflammation, Chronic Active | 1 2 2|
Necrosis | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Subcapsular, Hyperplasia | 2 2 2 1 1 1 1 1 1 1 2 1 2 2 2 1 3 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3|
| 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + I + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + M + + M + + M M M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + M + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 1 4 1 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia, Focal | 1 4 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M M + M + + M + + + + + + + + + + + + + + + + M|
Dilatation | 2 1 2 2 3 3 3 3 2 3 2 2 2 2 3 3 2 |
Inflammation, Chronic Active | 1 1 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | 2 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Oviduct | + + |
Cyst | 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 4 4 3 4 4 |
Hyperplasia, Cystic | 3 2 2 1 1 2 4 2 3 3 2 3 1 2 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + M + M + + + + + + + + + +|
Hemorrhage | 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | I + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 2 1 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 4 4 1 3 2 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3|
| 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | 1 |
Capsule, Inflammation, Chronic Active| 4 |
__________________________________________________________________________|
Thymus | + M + M + + M M M I + M + M M + + + + + M + + + +|
Atrophy | 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + M + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Inflammation, Chronic Active | 2 2 |
Ulcer | |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Abscess | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Subcutaneous Tissue, Pigmentation | |
Subcutaneous Tissue, Fat, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 2 2 1 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 1 |
Mineralization | 2 1 1 1 1 2 2 1 3 2 1|
Meninges, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation, Hemosiderin | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 1 1 1 2 1 2 2 2 2 |
Respiratory Epithelium, Hyperplasia, | |
Glandular | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3|
| 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Glomerulosclerosis | 2 |
Infarct | 1 |
Inflammation, Chronic | 1 2 1 1 |
Metaplasia, Osseous | 2 |
Renal Tubule, Degeneration, Hyaline | 2 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| |
| 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + + + + + + A + + + + + + M +| 43 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + M + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Eosinophilic Focus | 2 1 | 6 2.0|
Hematopoietic Cell Proliferation | 1 | 3 2.0|
Inflammation, Chronic Active | 1 1 1 | 7 1.6|
Necrosis | 1 | 2 1.5|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Inflammation, Chronic Active | | 2 2.5|
Fat, Necrosis | 4 4 | 5 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 2.0|
Acinar Cell, Atrophy | | 2 3.0|
Acinar Cell, Depletion Secretory | 3 | 1 3.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 3 1 2 2 1 1 1 2 | 28 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | | 1 3.0|
Inflammation, Chronic Active | | 3 1.7|
Necrosis | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| |
| 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 2 1 2 1 1 2 3 2 1 1 2 1 1 1| 47 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + M + M + + M + + M + M + + + + + + + M| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 | 2 2.5|
Pars Distalis, Hyperplasia | 1 1 1 2 2 2 2| 11 1.7|
Pars Intermedia, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + M + I + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 2 1.5|
Follicle, Cyst | 1 3 | 3 1.7|
Follicular Cell, Hyperplasia, Focal | 1 1 3 1 1 1 | 14 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + M + + M + + + + M| 41 |
Dilatation | 3 3 1 2 2 3 2 2 2 3 2 1 2 2 1 3 3 | 34 2.3|
Inflammation, Chronic Active | | 3 1.0|
Pigmentation | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | | 1 4.0|
Cyst | 4 4 2 4 | 5 3.2|
Inflammation, Chronic Active | 3 | 2 3.5|
__________________________________________________________________________|____________|
Oviduct | + | 3 |
Cyst | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 4 4 | 10 3.9|
Hyperplasia, Cystic | 2 2 2 3 3 3 3 2 3 1 1 2 2 2 2 3 2 3 2| 36 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 3 2 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| |
| 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Iliac, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + M| 45 |
Hemorrhage | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 1 | 4 1.5|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 1 1 4 4 2 1 | 17 2.6|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Hemosiderin | | 1 1.0|
Capsule, Inflammation, Chronic Active| | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + M +| 38 |
Atrophy | 3 2 2 4 | 5 2.8|
Hyperplasia, Lymphoid | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + M M + +| 45 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Inflammation, Chronic Active | 3 | 3 2.3|
Ulcer | 2 | 1 2.0|
Epidermis, Hyperplasia | 3 | 1 3.0|
Subcutaneous Tissue, Abscess | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
Subcutaneous Tissue, Pigmentation | 2 | 1 2.0|
Subcutaneous Tissue, Fat, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | 1 1 2 1 1 3 | 11 1.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 4 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| |
| 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hemorrhage | | 1 1.0|
Mineralization | 1 1 2 2 1 1 2 1 1 1 1 1 | 23 1.4|
Meninges, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 29 1.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
Pigmentation, Hemosiderin | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 1 2 2 2 1 2 1 1 3 2 2 1 2 | 27 1.7|
Respiratory Epithelium, Hyperplasia, | | |
Glandular | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 4 | 1 4.0|
Glomerulosclerosis | | 1 2.0|
Infarct | | 1 1.0|
Inflammation, Chronic | 1 1 1 1 1 | 9 1.1|
Metaplasia, Osseous | | 1 2.0|
Renal Tubule, Degeneration, Hyaline | | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 | 19 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4|
| 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + M + + + + M + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Eosinophilic Focus | X 4 1 2 |
Hematopoietic Cell Proliferation | 2 3 |
Inflammation, Chronic Active | 1 |
Mitotic Alteration | |
Necrosis | 4 3|
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 1 4 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | 1 |
Thrombosis | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 1|
Subcapsular, Hyperplasia | 1 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 2 2 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4|
| 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + M + + + M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 2 1 3 2 2 3 4 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Focal | 2 1 2 1 2 3 1 1 1 1 2 2 2 1 2 4 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + M + + + + +|
Dilatation | 4 2 1 2 2 1 1 3 2 2 2 2 2 3 3 2 3 3 2 2 2 |
Inflammation, Chronic Active | 1 3 1|
Pigmentation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 3 1 4 4 2 2 |
__________________________________________________________________________|
Oviduct | |
Dilatation | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 4 4 4 4 |
Hemorrhage | 2 |
Hyperplasia, Cystic | 2 2 3 2 3 2 3 1 2 2 3 3 3 2 2 3 4 2 1 2 1 3 1|
Inflammation, Chronic Active | 2 |
Lymphatic, Ectasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Myeloid Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | |
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4|
| 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 1 3 1 1 4 1 4|
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Thymus | + M + + + + M + + M + + + + + + + + + M + M + M +|
Atrophy | 2 4|
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 3 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 1 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Degeneration | |
Mineralization | 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 1 1 2 2 2 2 2 2 2 1 2 2 2 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4|
| 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 |
Nephropathy | |
Renal Tubule, Regeneration | 1 2 1 1 2 1 2 1 1 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 3 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3|
| 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 PPM | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + M M + + + + + + + + A + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Eosinophilic Focus | 3 1 1|
Hematopoietic Cell Proliferation | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 2 1 1|
Mitotic Alteration | 2 |
Necrosis | |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 3 4 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | 4 |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 |
Mineralization | |
Thrombosis | 3 1 |
Artery, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hematopoietic Cell Proliferation | |
Subcapsular, Hyperplasia | 1 1 1 1 2 1 1 1 2 1 2 2 1 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3|
| 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 PPM | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M M M M + + M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + M + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Focal | 1 1 1 2 1 1 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + M + + + M + + + M + M + + + + + + + +|
Dilatation | 3 2 2 3 2 2 1 2 3 2 2 3 2 3 2 3 1 3|
Inflammation, Chronic Active | 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 |
__________________________________________________________________________|
Oviduct | + |
Dilatation | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 4 3 |
Hemorrhage | 3 |
Hyperplasia, Cystic | 3 1 2 1 2 1 4 2 4 1 1 1 4 1 2 1 2|
Inflammation, Chronic Active | |
Lymphatic, Ectasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2|
Congestion | 3 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + M + + M + M + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + M + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 |
Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3|
| 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 PPM | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 3 4 4 4 4 2 3 2 4 4 |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Thymus | + + M + + + M + + + + + M + + + + + + + + M + + +|
Atrophy | 4 2 3 2 4 4 4 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Epidermis, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Degeneration | 2 |
Mineralization | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 1 2 2 1 1 1 2 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3|
| 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
750 PPM | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|
| 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 |
Nephropathy | 2 2 1 |
Renal Tubule, Regeneration | 1 1 1 2 2 1 1 1 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
750 PPM | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + | 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 48 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Cyst | | 1 2.0|
Eosinophilic Focus | | 7 2.0|
Hematopoietic Cell Proliferation | | 5 1.6|
Inflammation, Chronic Active | | 7 1.1|
Mitotic Alteration | | 1 2.0|
Necrosis | | 2 3.5|
Hepatocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Fat, Necrosis | | 8 2.8|
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Acinar Cell, Atrophy | | 1 4.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 50 |
Inflammation, Chronic | | 28 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Inflammation, Chronic Active | | 9 1.0|
Necrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
__________________________________________________________________________|____________|
Heart | + | 51 |
Fibrosis | | 2 1.0|
Mineralization | | 1 1.0|
Thrombosis | | 2 2.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
750 PPM | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Subcapsular, Hyperplasia | 2 | 46 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 47 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | | 12 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Inflammation, Chronic Active | | 6 1.0|
Follicle, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia, Focal | 2 | 29 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M | 43 |
Dilatation | | 39 2.2|
Inflammation, Chronic Active | | 4 1.5|
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + | 51 |
Cyst | | 11 2.6|
__________________________________________________________________________|____________|
Oviduct | | 1 |
Dilatation | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + | 51 |
Dilatation | | 10 3.6|
Hemorrhage | | 2 2.5|
Hyperplasia, Cystic | 3 | 41 2.1|
Inflammation, Chronic Active | | 1 2.0|
Lymphatic, Ectasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
750 PPM | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 1 2.0|
Congestion | | 1 3.0|
Myeloid Cell, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 46 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 48 |
Cyst | | 2 3.5|
Fibrosis | | 1 4.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 19 2.9|
Hyperplasia, Lymphoid | | 4 2.0|
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + | 41 |
Atrophy | | 9 3.2|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | | 5 1.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Inflammation, Chronic Active | | 2 3.0|
Epidermis, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Dysplasia | | 5 1.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Compression | | 1 2.0|
Degeneration | | 1 2.0|
Mineralization | 1 | 18 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
750 PPM | 6| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Congestion | | 1 2.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 | 22 1.1|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + | 51 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 32 1.7|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Inflammation, Chronic | 1 | 12 1.0|
Nephropathy | | 3 1.7|
Renal Tubule, Regeneration | 2 | 27 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Infiltration Cellular, Lymphocyte | 1 | 38 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2|
| 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1500 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + |
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + M + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Basophilic Focus | 3 |
Clear Cell Focus | X |
Cyst | 3 3 |
Eosinophilic Focus | 3 X 4 |
Fatty Change, Focal | |
Infarct | 4 2 |
Inflammation, Chronic Active | 1 1 1 1 |
Mineralization | 2 |
Mixed Cell Focus | X |
Necrosis | |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Inflammation, Chronic | |
Centrilobular, Pigmentation | |
__________________________________________________________________________|
Mesentery | + + +|
Artery, Inflammation, Chronic Active | 4|
Fat, Necrosis | 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Acinar Cell, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 4|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2|
| 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1500 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | 2 |
Hypertrophy, Focal | |
Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 2 2 1 1 1 1 2 2 2 1 2 1 1 2 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + M + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Hyperplasia | 2 |
Pars Distalis, Hyperplasia | 2 1 1 1 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1|
Follicle, Cyst | 1 3 1 |
Follicular Cell, Hyperplasia, Diffuse| 4 |
Follicular Cell, Hyperplasia, Focal | 3 1 2 2 1 2 2 1 1 1 2 2 1 2 2 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + M + + + + + + + M + + + M + + + + + +|
Dilatation | 2 2 2 3 3 3 2 3 3 3 2 2 3 2 2 2 3 2 3 2 2|
Inflammation, Chronic Active | 1 1 1 1 |
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2 4 2 4 4 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 3 3 |
Periovarian Tissue, Infiltration | |
Cellular, Lymphocyte | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Dilatation | 4 3 4 2 4 |
Hyperplasia, Cystic | 2 3 1 1 1 3 3 3 4 2 3 3 2 3 1 4 3 4 3 4 2|
Cervix, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Myeloid Cell, Hyperplasia | 3|
__________________________________________________________________________|
Lymph Node | +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2|
| 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1500 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | 3|
Inguinal, Pigmentation | 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 1 2 2 1 2 2 4 2|
Hyperplasia, Lymphoid | 2 2 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + M + + + + + M + + +|
Atrophy | 3 2 |
Ectopic Thyroid | |
Hyperplasia, Lymphoid | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 4 1 |
Epidermis, Hyperplasia | 2 |
Subcutaneous Tissue, Fat, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 2 2 1 |
Fracture | X |
Artery, Inflammation, Chronic Active | 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Infiltration Cellular, Histiocyte | 2|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2|
| 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1500 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + M + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 1 2 1 2 2 2 1 1 2 2 1 2 2 2 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + |
Atrophy | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Chronic | 1 1 1 1 |
Nephropathy | 3 2 |
Renal Tubule, Karyomegaly | 2 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Ureter | + |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
Artery, Inflammation, Chronic Active | 1|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + A + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | |
Clear Cell Focus | |
Cyst | |
Eosinophilic Focus | 2 3 X X 1 4 |
Fatty Change, Focal | 2 |
Infarct | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1|
Mineralization | |
Mixed Cell Focus | X |
Necrosis | 1 1 |
Bile Duct, Hyperplasia | |
Centrilobular, Inflammation, Chronic | 2 |
Centrilobular, Pigmentation | 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Artery, Inflammation, Chronic Active | |
Fat, Necrosis | 4 4 4 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Acinar Cell, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + M + + + + + + + + +|
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hypertrophy, Focal | 1 |
Subcapsular, Hyperplasia | 1 2 1 1 2 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + M M M + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Hyperplasia | |
Pars Distalis, Hyperplasia | 3 1 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
Follicle, Cyst | 1 2 |
Follicular Cell, Hyperplasia, Diffuse| |
Follicular Cell, Hyperplasia, Focal | 2 1 1 3 1 2 3 3 2 2 1 1 1 4 1 2 2 2 1 2 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + M + + + + + +|
Dilatation | 3 2 2 2 3 3 2 1 3 2 3 1 3 3 2 2 3 2 |
Inflammation, Chronic Active | 1 |
Pigmentation | 2 2 |
__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 4 1 1 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | |
Periovarian Tissue, Infiltration | |
Cellular, Lymphocyte | |
__________________________________________________________________________|
Uterus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Dilatation | 4 4 4 4 |
Hyperplasia, Cystic | 1 2 3 1 2 3 2 2 4 2 4 2 1 4 2 2 |
Cervix, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + M + + + + + + + + + M + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 2 4 2 2 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2|
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Ectopic Thyroid | X |
Hyperplasia, Lymphoid | 4 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 1 |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Fat, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 1 1 2 |
Fracture | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 2|
Infiltration Cellular, Histiocyte | |
Mineralization | 1 1 1 1 2 1 1 1 1 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 3 2 2 1 1 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 1 |
Inflammation, Chronic | 1 1 1 1 |
Nephropathy | |
Renal Tubule, Karyomegaly | |
Renal Tubule, Regeneration | 1 1 1 2 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Ureter | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1500 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 48 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 48 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Atrophy | | 1 3.0|
Basophilic Focus | | 1 3.0|
Clear Cell Focus | | 1 |
Cyst | | 2 3.0|
Eosinophilic Focus | | 9 2.8|
Fatty Change, Focal | | 1 2.0|
Infarct | | 2 3.0|
Inflammation, Chronic Active | | 12 1.0|
Mineralization | | 1 2.0|
Mixed Cell Focus | | 2 |
Necrosis | | 2 1.0|
Bile Duct, Hyperplasia | | 1 2.0|
Centrilobular, Inflammation, Chronic | | 1 2.0|
Centrilobular, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Artery, Inflammation, Chronic Active | | 1 4.0|
Fat, Necrosis | | 6 3.3|
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Inflammation, Chronic Active | | 1 2.0|
Acinar Cell, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Inflammation, Chronic | 2 | 27 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Hyperplasia | | 2 3.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1500 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 50 |
Aorta, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + | 51 |
Artery, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 50 |
Cyst | | 1 2.0|
Hypertrophy, Focal | | 1 1.0|
Subcapsular, Hyperplasia | 1 | 49 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 50 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 49 |
Craniopharyngeal Duct, Hyperplasia | | 1 2.0|
Pars Distalis, Hyperplasia | | 11 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Inflammation, Chronic Active | | 10 1.2|
Follicle, Cyst | | 5 1.6|
Follicular Cell, Hyperplasia, Diffuse| | 1 4.0|
Follicular Cell, Hyperplasia, Focal | 1 | 42 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 45 |
Dilatation | 1 | 40 2.4|
Inflammation, Chronic Active | | 5 1.0|
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + | 50 |
Cyst | | 12 2.6|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 2 3.0|
Periovarian Tissue, Infiltration | | |
Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1500 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 3.0|
Dilatation | | 9 3.7|
Hyperplasia, Cystic | 4 | 38 2.5|
Cervix, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Congestion | | 1 3.0|
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Inguinal, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Hyperplasia, Lymphoid | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 47 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Atrophy | | 1 3.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 18 2.2|
Hyperplasia, Lymphoid | | 6 2.0|
Pigmentation, Hemosiderin | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + | 47 |
Atrophy | | 4 2.5|
Ectopic Thyroid | | 1 |
Hyperplasia, Lymphoid | | 7 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 50 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + | 51 |
Inflammation, Chronic Active | | 6 2.2|
Epidermis, Hyperplasia | | 1 2.0|
Subcutaneous Tissue, Fat, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1500 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Dysplasia | | 8 1.6|
Fracture | | 1 |
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Compression | | 3 3.3|
Infiltration Cellular, Histiocyte | | 1 2.0|
Mineralization | 1 | 21 1.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Infiltration Cellular, Lymphocyte | 1 | 24 1.1|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + | 50 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 27 1.7|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Inflammation, Chronic Active | | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Infarct | | 2 1.5|
Inflammation, Chronic | | 8 1.0|
Nephropathy | | 2 2.5|
Renal Tubule, Karyomegaly | | 1 2.0|
Renal Tubule, Regeneration | | 31 1.1|
__________________________________________________________________________|____________|
Ureter | | 1 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1500 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Infiltration Cellular, Lymphocyte | 1 | 37 1.1|
Artery, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + M M + + + + + M + + + + + + M + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 |
Congestion | |
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | 2 1 |
Infarct | |
Inflammation, Chronic Active | 1 1 |
Mitotic Alteration | 2 |
Mixed Cell Focus | X |
Necrosis | 4 |
Kupffer Cell, Hypertrophy | 4 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Acinar Cell, Atrophy | 3 4 |
Duct, Cyst | 2 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation, Chronic Active | 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Chronic Active | 4 3 |
Subcapsular, Hyperplasia | 1 2 2 2 2 1 1 2 1 1 2 2 2 2 2 1 1 1 1 2 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M + M + + M + + M + + + M M M + M M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 1 |
Pars Distalis, Hyperplasia | 1 3 1 2 3 1 |
Pars Intermedia, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Follicle, Cyst | 3 2 |
Follicular Cell, Hyperplasia, Focal | 1 2 1 1 2 1 2 2 2 2 1 4 2 1 2 2 2 2 2 2 1 4 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + M + + + + + + + + + + + + +|
Dilatation | 1 2 3 2 2 2 3 2 2 2 2 2 3 2 2 3 3 2 3 2 2 2|
Inflammation, Chronic Active | 2 1 1 1 3 1 1|
Pigmentation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 |
Cyst | 1 |
Inflammation, Chronic Active | 3 |
Periovarian Tissue, Infiltration | |
Cellular, Lymphocyte | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 3 3|
Hyperplasia, Cystic | 2 2 4 2 1 1 1 2 1 2 4 3 2 2 2 2 3 4 1 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Hyperplasia, Plasma Cell| 4 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 2 3 2 4 2 4 3 |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | |
Capsule, Inflammation, Chronic Active| 3 |
__________________________________________________________________________|
Thymus | M + + + + M + + M + + + + + + M M + + + + + + + +|
Atrophy | 4 1 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
Subcutaneous Tissue, Fat, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Mineralization | 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Inflammation, Chronic Active | 3 |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | 4 |
Hydronephrosis | |
Infarct | 2 |
Inflammation, Chronic | 1 1 1 1 1 1|
Nephropathy | 1 |
Capsule, Inflammation, Chronic Active| 2 |
Glomerulus, Inflammation, Chronic | |
Perirenal Tissue, Inflammation, | |
Chronic Active | 3 |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 2 1 1 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + A + M + M + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | |
Congestion | 3 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 |
Infarct | 4 |
Inflammation, Chronic Active | 1 1|
Mitotic Alteration | |
Mixed Cell Focus | |
Necrosis | 3 |
Kupffer Cell, Hypertrophy | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic Active | 4 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4|
Acinar Cell, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 1 1 1 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Inflammation, Chronic Active | 3 |
Subcapsular, Hyperplasia | 1 1 2 1 1 1 1 2 2 1 2 2 2 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + M + + M + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 2 2 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2|
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia, Focal | 2 1 1 2 2 2 1 2 2 4 1 3 2 3 1 3 3 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + M + + + + + + + + M M + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 3 3 1 3 3 3 2 2 3 2 3 2|
Inflammation, Chronic Active | 2 1 1|
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | 4 2 2 2 3 |
Inflammation, Chronic Active | 4 |
Periovarian Tissue, Infiltration | |
Cellular, Lymphocyte | 3 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 4 |
Hyperplasia, Cystic | 1 3 2 4 4 2 1 2 1 2 2 4 3 1 1 2 3 2|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + +|
Mediastinal, Hyperplasia, Plasma Cell| |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 4 1 |
Hyperplasia, Lymphoid | 2 1 |
Pigmentation, Hemosiderin | 2 |
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Thymus | + + + M + + + + + + M + + M + + + + + + + + + +|
Atrophy | 3 3 4 4 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 |
Epidermis, Hyperplasia | 1 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Subcutaneous Tissue, Fat, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 1 1 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 2 2 1 2 2 2 2 3 2 1 2 2 1 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|
| 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
3000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic Active | 4 |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hemorrhage | |
Hydronephrosis | 1 |
Infarct | 1 |
Inflammation, Chronic | 1 1 1 1 1 1 1 |
Nephropathy | |
Capsule, Inflammation, Chronic Active| |
Glomerulus, Inflammation, Chronic | 2 |
Perirenal Tissue, Inflammation, | |
Chronic Active | |
Renal Tubule, Degeneration, Hyaline | 3 |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
3000 PPM | 7| | L |
| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + | 41 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 50 |
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 48 |
__________________________________________________________________________|____________|
Liver | + | 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | | 1 1.0|
Congestion | | 1 3.0|
Eosinophilic Focus | | 2 3.0|
Hematopoietic Cell Proliferation | | 3 1.7|
Infarct | | 1 4.0|
Inflammation, Chronic Active | | 4 1.0|
Mitotic Alteration | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis | | 2 3.5|
Kupffer Cell, Hypertrophy | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Inflammation, Chronic Active | | 1 4.0|
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + | 50 |
Inflammation, Chronic Active | | 2 3.5|
Acinar Cell, Atrophy | | 2 3.5|
Duct, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 50 |
Inflammation, Chronic | 1 | 23 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 50 |
Hyperplasia | | 1 3.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 49 |
Cyst | | 1 1.0|
Inflammation, Chronic Active | | 6 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
3000 PPM | 7| | L |
| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 49 |
__________________________________________________________________________|____________|
Heart | + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 50 |
Angiectasis | | 1 3.0|
Inflammation, Chronic Active | | 3 3.3|
Subcapsular, Hyperplasia | 1 | 45 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | M | 48 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 46 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Cyst | | 2 1.0|
Pars Distalis, Hyperplasia | | 10 2.1|
Pars Intermedia, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
Inflammation, Chronic Active | | 4 1.3|
Follicle, Cyst | | 3 2.7|
Follicular Cell, Hyperplasia, Focal | 2 | 44 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 44 |
Dilatation | 3 | 41 2.3|
Inflammation, Chronic Active | | 10 1.4|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + | 50 |
Abscess | | 3 4.0|
Cyst | | 6 2.3|
Inflammation, Chronic Active | | 2 3.5|
Periovarian Tissue, Infiltration | | |
Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
3000 PPM | 7| | L |
| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + | 50 |
Dilatation | | 7 3.4|
Hyperplasia, Cystic | 3 | 38 2.2|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 50 |
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 9 |
Mediastinal, Hyperplasia, Plasma Cell| | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Hyperplasia, Lymphoid | | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 48 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + | 50 |
Hematopoietic Cell Proliferation | | 14 2.3|
Hyperplasia, Lymphoid | | 3 1.7|
Pigmentation, Hemosiderin | | 1 2.0|
Capsule, Inflammation, Chronic Active| | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + | 42 |
Atrophy | | 6 3.2|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | | 4 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 50 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + | 50 |
Inflammation, Chronic Active | 3 | 5 1.6|
Epidermis, Hyperplasia | | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
Subcutaneous Tissue, Fat, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 50 |
Dysplasia | 1 | 6 1.3|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
3000 PPM | 7| | L |
| 9| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + | 50 |
Compression | | 1 3.0|
Mineralization | 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 50 |
Infiltration Cellular, Lymphocyte | | 20 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + | 50 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | | 41 1.9|
__________________________________________________________________________|____________|
Trachea | + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Inflammation, Chronic Active | | 2 3.5|
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 50 |
Atrophy | | 1 4.0|
Hemorrhage | | 1 4.0|
Hydronephrosis | | 1 1.0|
Infarct | | 2 1.5|
Inflammation, Chronic | | 13 1.0|
Nephropathy | | 1 1.0|
Capsule, Inflammation, Chronic Active| | 1 2.0|
Glomerulus, Inflammation, Chronic | | 1 2.0|
Perirenal Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
Renal Tubule, Degeneration, Hyaline | | 1 3.0|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Regeneration | | 19 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Infiltration Cellular, Lymphocyte | 1 | 36 1.1|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3|
| 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + + + M M + + + + A + + M + M + + + + + + M +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 X X |
Clear Cell Focus | X X 1 X X X |
Eosinophilic Focus | 3 2 X 2 3 |
Fatty Change, Focal | 1|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | |
Mitotic Alteration | |
Mixed Cell Focus | X |
Necrosis | 2 |
Centrilobular, Cytomegaly | 1 1 1 |
Centrilobular, Fatty Change | 1 4 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinar Cell, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + |
Developmental Malformation | X X X X X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 1 2 3 2 2 1 1 2 1 1 1 2 1|
Extra Adrenal Tissue, Inflammation, | |
Chronic Active | |
Subcapsular, Hyperplasia | 1 3 1 1 1 3 4 1 1 1 1 1 1 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3|
| 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M M + + + M + + + + + + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation, Chronic Active | 1 2 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Abscess | 4 |
Dilatation | 3 3 2 4 2 2 2 2 3 3 3 2 2 3 4 1 4 2 2 3 2|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 1 2 2 3 4 3 1 2 1 |
__________________________________________________________________________|
Prostate | M M + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 2 3 3 2 3 2 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + M M M + M + + + + M + + + + + M + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 |
Hemorrhage | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 3 3 1 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + M + + + + + + + + M +|
Atrophy | 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3|
| 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic Active | 2 4 |
Epidermis, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Mineralization | 3 2 2 2 2 1 1 1 1 1 1 2 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1|
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 2 2 |
Bronchiole, Hyperplasia | 2 |
Interstitium, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 2 2 2 2 2 2 1 2 2 2 2 1 1 1 |
Respiratory Epithelium, Hyperplasia, | |
Glandular | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
Hypertrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 2 1 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3|
| 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 2 1 1 1 1 1 2 3 2 1 1 1 2 1 2 2 2 2 1 2 2|
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Hyperplasia | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3| |
| 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M M M + + + + + + M M + + + M M M + + + +| 34 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 3 3.0|
Clear Cell Focus | X | 7 1.0|
Eosinophilic Focus | 1 2 X | 8 2.2|
Fatty Change, Focal | 1 1 1 | 4 1.0|
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Mitotic Alteration | 1 | 1 1.0|
Mixed Cell Focus | | 1 |
Necrosis | 1 | 2 1.5|
Centrilobular, Cytomegaly | | 3 1.0|
Centrilobular, Fatty Change | | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 | 1 1.0|
Acinar Cell, Atrophy | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1| 22 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + + | 9 |
Developmental Malformation | X X | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3| |
| 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hypertrophy, Focal | 1 2 1 1 2 1 2 1 2 2| 23 1.5|
Extra Adrenal Tissue, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
Subcapsular, Hyperplasia | 1 1 1 2 2 1 1 1 1 1 1 1 1 | 31 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 7 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M + + + + + + + M M M + + + M M M + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + I + + + + + + + + + M + +| 46 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Follicular Cell, Hyperplasia, Focal | 1 2 1 | 7 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic Active | 2 1| 5 1.4|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Abscess | | 1 4.0|
Dilatation | 4 2 3 3 3 1 4 2 1 4 3 4 3 2 1 1 3 4 4| 40 2.7|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Chronic Active | 4 4 1 3 1 2 3 1 1 1 1 2 1 | 23 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
Inflammation, Chronic | 1 1 1 1 1 1| 11 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 10 2.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + M + + + + + + + + + +| 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3| |
| 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 | 5 2.0|
Hemorrhage | 4 3 3 2 2 2| 13 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 1 1 3 3 2 2 3 3 | 14 2.3|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + M + + + M + + M + +| 43 |
Atrophy | 2 4 | 5 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M + M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
Epidermis, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 4.0|
Mineralization | 2 3 2 3 2 2 2 2 3 2 1 1 1 2 2 2 | 33 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 8 1.1|
Infiltration Cellular, Histiocyte | | 2 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 3 1| 6 2.0|
Bronchiole, Hyperplasia | | 1 2.0|
Interstitium, Inflammation, Chronic | | |
Active | 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 2 2 1 2 2 | 23 1.7|
Respiratory Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3| |
| 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Glandular | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Hypertrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 2 1.0|
Inflammation, Chronic | 1 1 1 1 1 | 8 1.0|
Inflammation, Chronic Active | 4 1 | 2 2.5|
Metaplasia, Osseous | | 2 1.5|
Nephropathy | 1 2 2 1 1 1 1 1 1 1 2 1 1 2 2 1 2 2 1 2 1 2| 45 1.5|
Renal Tubule, Degeneration, Hyaline | 2 | 1 2.0|
Renal Tubule, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1| 13 1.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05068-10 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 02/24/95
Route: DOSED FEED Time: 14:12:53
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7|
DAY ON TEST | 9| 2| 3| 9| 2| 3| 3| 0| 3| 3| 3| 3| 2| 1| 3| 2| 3| 2| 3| 2| 7| 3| 2| 5| 3|
| 6| 9| 0| 7| 9| 1| 1| 3| 1| 1| 0| 0| 9| 6| 1| 5| 1| 9| 1| 9| 4| 1| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
750 PPM | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + M + M + + + + + + + + + + + M + + + + + + +|
Degeneration, Hyaline | 2 |
Dilatation | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
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Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Cyst | 4 |
Eosinophilic Focus | 2 X 2 3 |
Fatty Change, Focal | 1 |
Infarct | 4 2 |
Inflammation, Chronic Active | 1 1 |
Mitotic Alteration | |
Mixed Cell Focus | |
Necrosis | 3 2 3 |
Pigmentation | |
Centrilobular, Fatty Change | 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas