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TDMS Study 05068-10 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                              CODEINE


NTP Experiment-Test: 05068-10                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 02/24/95
Route: DOSED FEED                                                                                                 Time: 14:12:53


                                                           CORE STUDY


       Facility:  Microbiological Associates

       Chemical CAS #:  76-57-3

       Lock Date:  03/03/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25023 Missing
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All































                                                             Page   1
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Eosinophilic Focus                   |          3  X  X                    X                                    |             
      Hematopoietic Cell Proliferation     |          3                 2                                             |             
      Inflammation, Chronic Active         |             1           2  4                       1                     |             
      Necrosis                             |    2                                                                     |             
      Centrilobular, Necrosis              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +  +              +                                      +      |             
      Inflammation, Chronic Active         |          3                 2                                             |             
      Fat, Necrosis                        |       4     3                                                     2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                            2     2                                       |             
      Acinar Cell, Atrophy                 |             2                    4                                       |             
      Acinar Cell, Depletion Secretory     |                                                                          |             
      Duct, Cyst                           |                                  4                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     1  1        1           1  1           2     1  1  1     1  1      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                        |             
      Inflammation, Chronic Active         |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                         3|             
      Inflammation, Chronic Active         |             1              2                                            2|             
      Necrosis                             |       2                 1                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |             2                                                            |             
      Subcapsular, Hyperplasia             | 2  2  2  1  1     1  1  1  1  1  2  1  2     2  2  1  3  1  2  2  1     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                    3                     |             
      Pars Distalis, Hyperplasia           |    1  4                    1     2                                       |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                            1               |             
      Follicle, Cyst                       |                                                                      1   |             
      Follicular Cell, Hyperplasia, Focal  |    1        4  1     1              1  1                 2     1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Dilatation                           | 2              1  2     2  3  3  3  3  2        3  2  2  2  2  3  3  2   |             
      Inflammation, Chronic Active         |                   1     1                                   1            |             
      Pigmentation                         |          1                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                            4                                             |             
      Cyst                                 |                                     2                                    |             
      Inflammation, Chronic Active         |                            4                                             |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                      +     +                                             |             
      Cyst                                 |                      3                                                   |             
      Inflammation, Chronic Active         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    4  4     4  4     3                             4           4         |             
      Hyperplasia, Cystic                  | 3           2     2        1  1  2  4  2     3     3  2  3  1  2  3  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |          3                 3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                       +                        |             
      Iliac, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             1           2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hemorrhage                           |       2                 2           1                                    |             
      Hyperplasia, Lymphoid                |                                                    4                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  4  4              4  4           1        3           2        1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Pigmentation, Hemosiderin            |                      1                                                   |             
      Capsule, Inflammation, Chronic Active|                            4                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  M  M  M  I  +  M  +  M  M  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Inflammation, Chronic Active         |                            2  2                                          |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Abscess         |                            4                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcutaneous Tissue, Pigmentation    |                                                                          |             
      Subcutaneous Tissue, Fat, Atrophy    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |          2  2                                         2  1           2   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             2                                                            |             
      Hemorrhage                           |                         1                                                |             
      Mineralization                       |       2  1        1  1                          1  2  2     1     3  2  1|             
      Meninges, Inflammation, Chronic      |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1        1        1        1  1  1  1              1  1  1        1      |             
      Infiltration Cellular, Histiocyte    |                                                    1                     |             
      Pigmentation, Hemosiderin            |                                                    1                     |             
      Alveolar Epithelium, Hyperplasia     |                               1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2        2           1  1  1  2  1                 2     2  2        2   |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Glandular                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 3| 9| 3| 5| 3| 3| 3| 2| 0| 3| 9| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 6| 4| 3| 5| 4| 4| 4| 5| 0| 9| 6| 6| 5| 2| 9| 5| 1| 6| 6| 4| 4| 5| 6| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 1| 2| 4| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                 +   |             
      Hyperplasia, Focal                   |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Glomerulosclerosis                   |                            2                                             |             
      Infarct                              |                                                                      1   |             
      Inflammation, Chronic                |                                  1           2     1  1                  |             
      Metaplasia, Osseous                  |                               2                                          |             
      Renal Tubule, Degeneration, Hyaline  |                         2                                                |             
      Renal Tubule, Regeneration           | 1  1           1                 1  1              1  1  1     1  1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1     1  1  1     1  1     1  1        1     1     1  1  1     1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +|  43        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                              2           1               |      6  2.0|
      Hematopoietic Cell Proliferation     |                                                    1                     |      3  2.0|
      Inflammation, Chronic Active         |                         1                                   1     1      |      7  1.6|
      Necrosis                             |                1                                                         |      2  1.5|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                    +     +                          +         |   9        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Fat, Necrosis                        |          4                    4                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                 2                        |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Acinar Cell, Atrophy                 |                                                                          |      2  3.0|
      Acinar Cell, Depletion Secretory     |                                                       3                  |      1  3.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 1  1     1  1  1  1  1     1  3     1     2     2     1  1     1     2   |     28  1.2|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                           1                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  1.7|
      Necrosis                             |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                       1                  |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Subcapsular, Hyperplasia             | 1  1  1  1  1  1  1  1  1  1  2  2  1  2  1  1  2  3  2  1  1  2  1  1  1|     47  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  M  +  M  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  M|  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                        2                                 |      2  2.5|
      Pars Distalis, Hyperplasia           | 1        1     1              2                             2        2  2|     11  1.7|
      Pars Intermedia, Hyperplasia         |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Follicle, Cyst                       |                                        1                             3   |      3  1.7|
      Follicular Cell, Hyperplasia, Focal  |                1        1              3     1              1        1   |     14  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  M|  41        |
      Dilatation                           | 3  3  1  2  2  3     2  2  2  3  2           1     2  2     1  3  3      |     34  2.3|
      Inflammation, Chronic Active         |                                                                          |      3  1.0|
      Pigmentation                         |                   1                                                  2   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                                          |      1  4.0|
      Cyst                                 | 4           4                                2     4                     |      5  3.2|
      Inflammation, Chronic Active         |                                  3                                       |      2  3.5|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                            +                                             |   3        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                               4                                   4  4   |     10  3.9|
      Hyperplasia, Cystic                  | 2  2  2  3  3  3  3  2  3  1  1     2  2        2  2     3  2  3        2|     36  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |                                  3  2                                    |      4  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                  +  +                                    |   4        |
      Iliac, Inflammation, Chronic Active  |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Hemorrhage                           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                              1                           |      4  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2     3     1  1                 4  4                          2     1   |     17  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  38        |
      Atrophy                              |                            3     2  2                 4                  |      5  2.8|
      Hyperplasia, Lymphoid                |                      1                                                   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  45        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                       X                  |      1     |
      Inflammation, Chronic Active         | 3                                                                        |      3  2.3|
      Ulcer                                | 2                                                                        |      1  2.0|
      Epidermis, Hyperplasia               |                                                                      3   |      1  3.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                      3   |      1  3.0|
      Subcutaneous Tissue, Pigmentation    |                                                                      2   |      1  2.0|
      Subcutaneous Tissue, Fat, Atrophy    |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                1     1        2                          1  1        3   |     11  1.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                     3     4                              |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 5| 7| 4| 7| 2| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 7| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 1| 5| 6| 5| 5| 2| 4| 1| 2| 5| 0| 6| 7| 4| 2| 6| 5| 5| 5| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0 PPM                                  | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 1| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  1.0|
      Mineralization                       |       1  1  2  2  1        1  2           1  1  1  1              1      |     23  1.4|
      Meninges, Inflammation, Chronic      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    | 1  1     1  1  1  1  1  1     1     1  1  1  2  1        1        1  1  1|     29  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  2  2  1     2        2  2     1     2  1        1  3  2     2  1  2   |     27  1.7|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Glandular                       |       2                             2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition                   |                                                       4                  |      1  4.0|
      Glomerulosclerosis                   |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |    1        1           1                 1                          1   |      9  1.1|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           | 1  1     1  1                       1                    1           1   |     19  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 4                                                                        |      1  4.0|
      Infiltration Cellular, Lymphocyte    |    1     1  1     1        1  1           1  1  1  1     1           1  1|     30  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4|             
                                           | 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          2               |             
      Eosinophilic Focus                   |                                  X        4     1  2                     |             
      Hematopoietic Cell Proliferation     |       2                                                     3            |             
      Inflammation, Chronic Active         |                                                                1         |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis                             |                                                             4           3|             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                               +           +         |             
      Fat, Necrosis                        |    1                                               4           2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Atrophy                 |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1  1  2  1  2  1     1        1  1  1  1     1  1  1  1  2               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                 1     1                    1     1                     |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Mineralization                       |                                                             1            |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |       3                                                                 1|             
      Subcapsular, Hyperplasia             | 1  2  2  1  2  1  1  1  1     1  1  1  1  1  1  1  1  2  1  2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4|             
                                           | 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  2                                       |             
      Pars Distalis, Cyst                  |       1                                                                  |             
      Pars Distalis, Hyperplasia           | 2  1  3  2  2                                            3     4  2  1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                                               1        1               |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  | 2  1  2  1  2     3  1  1  1  1  2  2     2     1  2     4     1  2     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Dilatation                           | 4  2  1  2  2  1  1  3  2  2  2  2  2  3  3  2     3  3     2     2  2   |             
      Inflammation, Chronic Active         |                   1                                            3        1|             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       4     2  3              1                 4     4     2  2         |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       4     2                       4           4        4     4         |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia, Cystic                  | 2  2     3  2  3  2  3  1  2  2  3  3  3  2  2     3  4  2  1  2  1  3  1|             
      Inflammation, Chronic Active         |                                     2                                    |             
      Lymphatic, Ectasia                   |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |       3                                                     3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                      +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
      Hyperplasia, Lymphoid                |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4|             
                                           | 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             3            |             
      Hemorrhage                           |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |       4           1        3              1        1        4        1  4|             
      Hyperplasia, Lymphoid                |                2     2                                                   |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +|             
      Atrophy                              |                                                             2           4|             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                3                 1     1                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               2                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |          2        1                                                  3   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Degeneration                         |                                                                          |             
      Mineralization                       |    1        1  1           1              1  1  1  1                    1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           | 2                                                                        |             
      Infiltration Cellular, Lymphocyte    |    1  1  1  1  2     1              1  1     1     1     1     1         |             
      Alveolar Epithelium, Hyperplasia     |                                                                         3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2  1  1        2  2  2  2        2  2  2     1           2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                   +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 4|             
                                           | 4| 4| 5| 1| 5| 5| 4| 5| 5| 2| 4| 5| 5| 4| 4| 5| 5| 6| 5| 4| 9| 4| 3| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     1  1        1                       1     1  1                     |             
      Nephropathy                          |                                                                          |             
      Renal Tubule, Regeneration           | 1                 2  1  1           2  1  2  1  1  1  2  1     2     1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1  3  2  1  1  1  1  1  1  1  1  1  1     1  1  1  1  2  1  1     1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3|             
                                           | 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750 PPM                                | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                   3                                               1     1|             
      Hematopoietic Cell Proliferation     |       1     1     1                                                      |             
      Inflammation, Chronic Active         |                1                    1        1                    2  1  1|             
      Mitotic Alteration                   |                                  2                                       |             
      Necrosis                             |                                                                          |             
      Hepatocyte, Necrosis                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +  +        +                                      +  +   |             
      Fat, Necrosis                        |    3           3           4                                      3  2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Atrophy                 |                                                                   4      |             
      Duct, Cyst                           |                                                                   4      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2           1        2  1        1        1     1  1  1     1  1  1   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1  1                                   1           1      |             
      Necrosis                             | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               1                    1                     |             
      Mineralization                       |                                                                          |             
      Thrombosis                           | 3                                                           1            |             
      Artery, Inflammation, Chronic Active |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Subcapsular, Hyperplasia             | 1  1  1  1  2  1  1  1  2  1  2  2     1     2     1     1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3|             
                                           | 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750 PPM                                | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  M  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                2                                         2              1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      1              1                                1   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  | 1  1           1  2  1              1              1              3  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3  2  2        3     2  2  1     2  3  2     2     3     2  3  2  3  1  3|             
      Inflammation, Chronic Active         |                1                                                         |             
      Pigmentation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                             3        2                                 |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                               +                                          |             
      Dilatation                           |                               3                                          |             
      Inflammation, Chronic Active         |                               3                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                4  3                                            4  3      |             
      Hemorrhage                           |       3                                                                  |             
      Hyperplasia, Cystic                  | 3  1  2  1        2  1  4  2        4  1     1     1     4  1  2     1  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Lymphatic, Ectasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         2|             
      Congestion                           |                                                 3                        |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                                            4   |             
      Fibrosis                             | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3|             
                                           | 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750 PPM                                | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                               1                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2                                                                        |             
      Hematopoietic Cell Proliferation     | 2     3     4     4     4     4  2  3              2        4     4      |             
      Hyperplasia, Lymphoid                |                                              2                       2   |             
      Infiltration Cellular, Plasma Cell   |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              | 4        2  3                 2           4     4           4            |             
      Ectopic Parathyroid Gland            |                                                             X            |             
      Hyperplasia, Lymphoid                |    2                                                     1               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   4                                                      |             
      Epidermis, Hyperplasia               |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                   1                 1                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                        2                                 |             
      Degeneration                         |                                        2                                 |             
      Mineralization                       | 1  1                                1                    1     1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       2                  |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1  1           1  2  1           1  1        1                       1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  1  1  1  2  2  1           1  1  2              2     2     2  2     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                    +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 3| 7| 7| 7| 6| 7| 6| 3| 7| 5| 0| 7| 0| 7| 3| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 5| 3| 3| 3| 1| 3| 6| 8| 3| 1| 0| 3| 0| 3| 4| 3| 2| 3| 3| 3| 3|             
                                           | 7| 5| 4| 9| 9| 4| 4| 4| 6| 4| 4| 8| 6| 2| 8| 4| 8| 4| 8| 4| 5| 4| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    750 PPM                                | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
                                           | 8| 9| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1                                   1           1           1         |             
      Nephropathy                          | 2                                   2                             1      |             
      Renal Tubule, Regeneration           |    1  1        1  2  2     1                 1     1     2     1     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1           1  1     1  1  1  1  2        1              1  1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    750 PPM                                | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Cyst                                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      7  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      5  1.6|
      Inflammation, Chronic Active         |                                                                          |      7  1.1|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  3.5|
      Hepatocyte, Necrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Fat, Necrosis                        |                                                                          |      8  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Acinar Cell, Atrophy                 |                                                                          |      1  4.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  50        |
      Inflammation, Chronic                |                                                                          |     28  1.2|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      9  1.0|
      Necrosis                             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Fibrosis                             |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      2  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    750 PPM                                | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Subcapsular, Hyperplasia             | 2                                                                        |     46  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  47        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |     12  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      6  1.0|
      Follicle, Cyst                       | 2                                                                        |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  | 2                                                                        |     29  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M                                                                        |  43        |
      Dilatation                           |                                                                          |     39  2.2|
      Inflammation, Chronic Active         |                                                                          |      4  1.5|
      Pigmentation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  51        |
      Cyst                                 |                                                                          |     11  2.6|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Dilatation                           |                                                                          |     10  3.6|
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Cystic                  | 3                                                                        |     41  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Lymphatic, Ectasia                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    750 PPM                                | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  46        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  48        |
      Cyst                                 |                                                                          |      2  3.5|
      Fibrosis                             |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |     19  2.9|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  41        |
      Atrophy                              |                                                                          |      9  3.2|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Dysplasia                            |                                                                          |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Compression                          |                                                                          |      1  2.0|
      Degeneration                         |                                                                          |      1  2.0|
      Mineralization                       | 1                                                                        |     18  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 5|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    750 PPM                                | 6|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 1                                                                        |     22  1.1|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                                          |     32  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Inflammation, Chronic                | 1                                                                        |     12  1.0|
      Nephropathy                          |                                                                          |      3  1.7|
      Renal Tubule, Regeneration           | 2                                                                        |     27  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |     38  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2|             
                                           | 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1500 PPM                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Ulcer                                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                3         |             
      Basophilic Focus                     |                                        3                                 |             
      Clear Cell Focus                     |                                  X                                       |             
      Cyst                                 |             3                                                  3         |             
      Eosinophilic Focus                   |             3                                            X        4      |             
      Fatty Change, Focal                  |                                                                          |             
      Infarct                              |                               4                                      2   |             
      Inflammation, Chronic Active         |    1                    1     1              1                           |             
      Mineralization                       |                                                                2         |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |             2                                                            |             
      Centrilobular, Inflammation, Chronic |                                                                          |             
      Centrilobular, Pigmentation          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                            +  +|             
      Artery, Inflammation, Chronic Active |                                                                         4|             
      Fat, Necrosis                        |                         2                                            4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinar Cell, Atrophy                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1           1  1        1  1        1  1                 1  1  1  1  1   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                3         |             
      Inflammation, Chronic Active         |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic Active  |                               2                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2|             
                                           | 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1500 PPM                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                2         |             
      Hypertrophy, Focal                   |                                                                          |             
      Subcapsular, Hyperplasia             | 1  1  1  1  1  1  1  2  2  1  1  1  1  2  2  2  1  2     1  1  2  1  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                              3                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Hyperplasia   |             2                                                            |             
      Pars Distalis, Hyperplasia           |                      2  1     1  1        3        2              2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1           1                    1        1           1        1  2  1|             
      Follicle, Cyst                       |             1  3              1                                          |             
      Follicular Cell, Hyperplasia, Diffuse|                                                                      4   |             
      Follicular Cell, Hyperplasia, Focal  | 3  1     2  2  1  2     2  1  1  1  2  2     1  2  2  1  1  1  1  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Dilatation                           | 2     2  2  3  3     3  2  3  3  3  2  2     3  2  2     2  3  2  3  2  2|             
      Inflammation, Chronic Active         |                            1                 1  1  1                     |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 1                                2     4           2        4     4      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                 3  3                     |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Lymphocyte             |                         3                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3                        |             
      Dilatation                           | 4        3                 4                 2                       4   |             
      Hyperplasia, Cystic                  |       2  3  1  1  1  3  3     3  4  2  3  3  2     3  1  4  3  4  3  4  2|             
      Cervix, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2|             
                                           | 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1500 PPM                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                         3|             
      Inguinal, Pigmentation               |                                                                         1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                    4                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hematopoietic Cell Proliferation     |                                                 2     2                  |             
      Hemorrhage                           |                                                       2                  |             
      Infiltration Cellular, Histiocyte    |                                                                1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                       2                  |             
      Hematopoietic Cell Proliferation     |    1     1  2                 2     1     2     2     4                 2|             
      Hyperplasia, Lymphoid                | 2                       2                          2                     |             
      Pigmentation, Hemosiderin            |                                                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                               3                       2                  |             
      Ectopic Thyroid                      |                                                                          |             
      Hyperplasia, Lymphoid                |       2                          2        2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      4   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                   4                 1      |             
      Epidermis, Hyperplasia               |                                                 2                        |             
      Subcutaneous Tissue, Fat, Atrophy    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |          2           2                 2  1                              |             
      Fracture                             |                                                 X                        |             
      Artery, Inflammation, Chronic Active |                                                                         3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                      4   |             
      Infiltration Cellular, Histiocyte    |                                                                         2|             
      Mineralization                       |                1     1        1  1  1  1              1  1  1  1  1      |             
      Artery, Inflammation, Chronic Active |                                                                         2|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 2|             
                                           | 4| 6| 5| 4| 6| 5| 6| 5| 5| 4| 4| 6| 5| 4| 6| 5| 5| 4| 4| 4| 4| 3| 5| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1500 PPM                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 1| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1           1                          1              1  1  2     2      |             
      Alveolar Epithelium, Hyperplasia     |                         1                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2     2  1  2     1  2  2  2  1  1  2  2     1  2              2  2  2  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic Active         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
      Inflammation, Chronic Active         |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |    1                                1                    1        1      |             
      Nephropathy                          |                               3                 2                        |             
      Renal Tubule, Karyomegaly            |                                                 2                        |             
      Renal Tubule, Regeneration           | 1  1  1  1  1  1  1  1  1  1     1  1     1  1     1     1  1     1  1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                         +                                                |             
      Infiltration Cellular, Lymphocyte    |                         1                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1     1  1     1     1  1  1  1  1  1  1  1  1     1  1  1  1  2  1  1   |             
      Artery, Inflammation, Chronic Active |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |       2  3     X                    X     1                 4            |             
      Fatty Change, Focal                  |                                        2                                 |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         | 1                 1                 1     1     1                 1  1  1|             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                                                 X                        |             
      Necrosis                             |                                           1        1                     |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Inflammation, Chronic |             2                                                            |             
      Centrilobular, Pigmentation          |             2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +           +                                      +           +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |          4           4                                      4           2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  2                                       |             
      Acinar Cell, Atrophy                 |                                                                      2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1  1  1  1        1     1           1  1     1  2  1     1     1  1      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 3                        |             
      Inflammation, Chronic Active         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hypertrophy, Focal                   |                                              1                           |             
      Subcapsular, Hyperplasia             | 1  2  1  1  2  1  1  1  1     1  1  2  1  1  1  2  2  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  M  M  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Hyperplasia   |                                                                          |             
      Pars Distalis, Hyperplasia           | 3     1                                   3                 2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              2                       1   |             
      Follicle, Cyst                       |                   1                                      2               |             
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |             
      Follicular Cell, Hyperplasia, Focal  | 2  1  1  3     1  2  3  3     2  2  1  1  1  4     1  2  2  2     1  2  4|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Dilatation                           | 3  2     2  2     3  3  2        1  3  2  3  1  3  3     2  2  3  2      |             
      Inflammation, Chronic Active         |    1                                                                     |             
      Pigmentation                         | 2                                                              2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      4  2        4              1           1     2      |             
      Hemorrhage                           |                                                                   2      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Dilatation                           |    4                                4  4                 4               |             
      Hyperplasia, Cystic                  | 1     2  3     1  2  3  2     2  4           2  4  2        1  4  2  2   |             
      Cervix, Inflammation, Chronic Active |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            3                                             |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2                                                           3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                             |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    3  2     2  4        2              2                 3  2        2   |             
      Hyperplasia, Lymphoid                |                   2              2                                      2|             
      Pigmentation, Hemosiderin            |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                                            2               |             
      Ectopic Thyroid                      |                                     X                                    |             
      Hyperplasia, Lymphoid                |                      4                                         2     2  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                2  3                                   1                  |             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Fat, Atrophy    |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                               2           1              1     2         |             
      Fracture                             |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                          4              2|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Mineralization                       | 1  1           1  1  2  1                 1           1        1         |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 0| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 5| 5| 9| 3| 6| 5| 4| 8| 4| 5| 7| 5| 5| 5| 5| 6| 4| 1| 5| 6| 4| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1500 PPM                               | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1  1              1  1  1        1  1  1  1  1  1     1     1  1  1  1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                      1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |       2     3     2                 2  1     1        1  2     2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Atrophy                              |                                        4                                 |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                 +                                 |             
      Inflammation, Chronic Active         |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |          2                                         1                     |             
      Inflammation, Chronic                |       1        1  1           1                                          |             
      Nephropathy                          |                                                                          |             
      Renal Tubule, Karyomegaly            |                                                                          |             
      Renal Tubule, Regeneration           | 1     1  1     2  1     2                       1        1  1  2     1  1|             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1        1        1  1  1     1        2  1     2  1  1  1  1  1  1     1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1500 PPM                               | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  48        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Atrophy                              |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Cyst                                 |                                                                          |      2  3.0|
      Eosinophilic Focus                   |                                                                          |      9  2.8|
      Fatty Change, Focal                  |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |     12  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis                             |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Centrilobular, Inflammation, Chronic |                                                                          |      1  2.0|
      Centrilobular, Pigmentation          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      6  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinar Cell, Atrophy                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Inflammation, Chronic                | 2                                                                        |     27  1.1|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1500 PPM                               | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  50        |
      Aorta, Inflammation, Chronic Active  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Subcapsular, Hyperplasia             | 1                                                                        |     49  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  50        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  49        |
      Craniopharyngeal Duct, Hyperplasia   |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     11  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |     10  1.2|
      Follicle, Cyst                       |                                                                          |      5  1.6|
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |      1  4.0|
      Follicular Cell, Hyperplasia, Focal  | 1                                                                        |     42  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  45        |
      Dilatation                           | 1                                                                        |     40  2.4|
      Inflammation, Chronic Active         |                                                                          |      5  1.0|
      Pigmentation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  50        |
      Cyst                                 |                                                                          |     12  2.6|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  3.0|
      Periovarian Tissue, Infiltration     |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1500 PPM                               | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |      9  3.7|
      Hyperplasia, Cystic                  | 4                                                                        |     38  2.5|
      Cervix, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Congestion                           |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Inguinal, Pigmentation               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  47        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Atrophy                              |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |     18  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  47        |
      Atrophy                              |                                                                          |      4  2.5|
      Ectopic Thyroid                      |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      7  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  50        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Inflammation, Chronic Active         |                                                                          |      6  2.2|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fat, Atrophy    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1500 PPM                               | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Dysplasia                            |                                                                          |      8  1.6|
      Fracture                             |                                                                          |      1     |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Compression                          |                                                                          |      3  3.3|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Mineralization                       | 1                                                                        |     21  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |     24  1.1|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  50        |
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                                          |     27  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Atrophy                              |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Infarct                              |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      8  1.0|
      Nephropathy                          |                                                                          |      2  2.5|
      Renal Tubule, Karyomegaly            |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                          |     31  1.1|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    1500 PPM                               | 2|                                                                       |      L     |
                                           | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |     37  1.1|
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                                                                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                              1                           |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                      3                                                   |             
      Hematopoietic Cell Proliferation     |                                              2              1            |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                            1        1                                    |             
      Mitotic Alteration                   |                                                                      2   |             
      Mixed Cell Focus                     |                                                                   X      |             
      Necrosis                             | 4                                                                        |             
      Kupffer Cell, Hypertrophy            |                                                             4            |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             3            |             
      Acinar Cell, Atrophy                 |                                           3              4               |             
      Duct, Cyst                           |                                           2              4               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             1  1        1  1  1     1  1  1        1     1  1           1|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                       1                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      1                                                   |             
      Inflammation, Chronic Active         |             1                                                           1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic Active         |                                              4              3            |             
      Subcapsular, Hyperplasia             | 1  2     2  2  2  1  1  2  1  1  2  2  2  2  2  1  1  1  1  2  1  2     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  +  M  +  +  M  +  +  M  +  +  +  M  M  M  +  M  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                        1                       1         |             
      Pars Distalis, Hyperplasia           |       1     3  1                             2  3  1                     |             
      Pars Intermedia, Hyperplasia         |                               3                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  1                                       |             
      Follicle, Cyst                       |       3     2                                                            |             
      Follicular Cell, Hyperplasia, Focal  | 1  2  1  1  2  1  2  2     2  2  1     4  2  1  2  2  2  2  2  2  1  4  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1  2  3     2  2  2  3     2  2     2  2  2  3  2  2  3  3  2  3  2  2  2|             
      Inflammation, Chronic Active         | 2  1           1                    1     3                       1     1|             
      Pigmentation                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                              4              4            |             
      Cyst                                 |                               1                                          |             
      Inflammation, Chronic Active         |                                                             3            |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Lymphocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                  +                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          4                                      4  3                    3|             
      Hyperplasia, Cystic                  |    2  2     4  2     1  1  1  2  1  2  4  3  2  2  2  2        3  4  1   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +     +     +              +                           |             
      Mediastinal, Hyperplasia, Plasma Cell|                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3              1  2        3  2        4           2  4  3         |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Capsule, Inflammation, Chronic Active|                                              3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4                          1                                       |             
      Ectopic Parathyroid Gland            |                                                          X               |             
      Hyperplasia, Lymphoid                |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             1            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   1      |             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                3         |             
      Subcutaneous Tissue, Fat, Atrophy    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                     1                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            3                                             |             
      Mineralization                       | 1                                                              1     1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1        1  1           1     1     1     1     1  1        1         |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2  3  2  2  2  2  2  2     2  2  2     2  2     2  2  2  2  2  1  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 5| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 8| 1| 3| 3| 5| 3| 9| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 6| 0| 9| 5| 6| 6| 5| 8| 5| 4| 6| 4| 4| 4| 1| 6| 4| 5| 4| 1| 4| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3000 PPM                               | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +        +                                    |             
      Inflammation, Chronic Active         |                                     3                                    |             
      Cornea, Inflammation, Chronic Active |                            3                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +        +                                    |             
      Inflammation, Chronic Active         |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |       4                                                                  |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                      2                                                   |             
      Inflammation, Chronic                | 1  1                                         1     1  1                 1|             
      Nephropathy                          |                                                          1               |             
      Capsule, Inflammation, Chronic Active|                                                             2            |             
      Glomerulus, Inflammation, Chronic    |                                                                          |             
      Perirenal Tissue, Inflammation,      |                                                                          |             
          Chronic Active                   |                                              3                           |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |    1                                2     1           1        2  2  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  2  1     2  1        1  1  1  1  1        1  1  2  1           1  1  1|             
      Inflammation, Chronic Active         |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  A  +  M  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      1   |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                               3                                          |             
      Eosinophilic Focus                   |                         X                                                |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Infarct                              |                               4                                          |             
      Inflammation, Chronic Active         |                            1                                            1|             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |    3                                                                     |             
      Kupffer Cell, Hypertrophy            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                 +  +                 +                              |             
      Inflammation, Chronic Active         |                                           4                              |             
      Fat, Necrosis                        |                      3  3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         4|             
      Acinar Cell, Atrophy                 |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1     1  1        1     1  1              1     1           1  1   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3                                 |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                        2        3                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |             1                             1              1              2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               3                                          |             
      Inflammation, Chronic Active         |                                           3                              |             
      Subcapsular, Hyperplasia             | 1     1  2  1  1     1  1  2  2  1     2  2  2  1  1  2     1  1  1  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1  2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  M  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                      2  2|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |    3                                                  2     2     3      |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                                                     1     2|             
      Follicle, Cyst                       |                                                                3         |             
      Follicular Cell, Hyperplasia, Focal  | 2  1  1     2  2     2  1  2  2  4        1  3  2  3  1     3  3  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  M  +  +  +  +  +  +  +  +     M  M  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    2  2     2  2     2  2  3  3  1           3  3  3  2     2  3  2  3  2|             
      Inflammation, Chronic Active         |                                                       2     1           1|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                           4                              |             
      Cyst                                 |    4     2                 2                       2           3         |             
      Inflammation, Chronic Active         |                                           4                              |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Lymphocyte             |                                              3                           |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             2                    4           4                           |             
      Hyperplasia, Cystic                  | 1  3  2        4     4  2  1           2  1  2  2  4  3     1  1  2  3  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                       +                       +        +|             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      3     2                    3                 3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             1              1  1           4                          1   |             
      Hyperplasia, Lymphoid                |                      2                                            1      |             
      Pigmentation, Hemosiderin            | 2                                                                        |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  M  +     +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3              4                                      4               |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |       1                                         1                 1      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                                1                 2         |             
      Epidermis, Hyperplasia               |             1                                                            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcutaneous Tissue, Fat, Atrophy    |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |       1                          1                 1                 3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Mineralization                       |    1                 1        1           1                       1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1     1  1     1           1              1           1     1  1  1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  1  2  2  1        2  2  2  2        3  2  1  2  2        1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 8| 5| 7| 4| 5| 8| 5| 4| 4| 2| 6| 0| 7| 1| 5| 4| 4| 4| 8| 5| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    3000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Inflammation, Chronic Active         |                            4                                             |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4                                                                     |             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |    1                                                                     |             
      Infarct                              |                         1                                                |             
      Inflammation, Chronic                |             1  1     1     1  1              1              1            |             
      Nephropathy                          |                                                                          |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
      Glomerulus, Inflammation, Chronic    |                                           2                              |             
      Perirenal Tissue, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                                        3                                 |             
      Renal Tubule, Pigmentation           |                               2                                          |             
      Renal Tubule, Regeneration           |       1     1        1  1  1     1           2  1     1           1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1     1  1  1  1     1  1  1  1  1        1  1  1  1        1     1  2  1|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 4|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    3000 PPM                               | 7|                                                                       |      L     |
                                           | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  41        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      4  1.0|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      2  3.5|
      Kupffer Cell, Hypertrophy            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Acinar Cell, Atrophy                 |                                                                          |      2  3.5|
      Duct, Cyst                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  50        |
      Inflammation, Chronic                | 1                                                                        |     23  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Acute                  | 1                                                                        |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  49        |
      Cyst                                 |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      6  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 4|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    3000 PPM                               | 7|                                                                       |      L     |
                                           | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
      Subcapsular, Hyperplasia             | 1                                                                        |     45  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | M                                                                        |  48        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  46        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |     10  2.1|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      4  1.3|
      Follicle, Cyst                       |                                                                          |      3  2.7|
      Follicular Cell, Hyperplasia, Focal  | 2                                                                        |     44  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  44        |
      Dilatation                           | 3                                                                        |     41  2.3|
      Inflammation, Chronic Active         |                                                                          |     10  1.4|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  50        |
      Abscess                              |                                                                          |      3  4.0|
      Cyst                                 |                                                                          |      6  2.3|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Periovarian Tissue, Infiltration     |                                                                          |            |
          Cellular, Lymphocyte             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 4|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    3000 PPM                               | 7|                                                                       |      L     |
                                           | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  50        |
      Dilatation                           |                                                                          |      7  3.4|
      Hyperplasia, Cystic                  | 3                                                                        |     38  2.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  50        |
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   9        |
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  48        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |     14  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  42        |
      Atrophy                              |                                                                          |      6  3.2|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  50        |
      Inflammation, Chronic Active         | 3                                                                        |      5  1.6|
      Epidermis, Hyperplasia               |                                                                          |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Subcutaneous Tissue, Fat, Atrophy    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  50        |
      Dysplasia                            | 1                                                                        |      6  1.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 4|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   B6C3F1 MICE FEMALE                      | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    3000 PPM                               | 7|                                                                       |      L     |
                                           | 9|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  50        |
      Compression                          |                                                                          |      1  3.0|
      Mineralization                       | 1                                                                        |     10  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |     20  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  50        |
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                                          |     41  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydronephrosis                       |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |     13  1.0|
      Nephropathy                          |                                                                          |      1  1.0|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  2.0|
      Glomerulus, Inflammation, Chronic    |                                                                          |      1  2.0|
      Perirenal Tissue, Inflammation,      |                                                                          |            |
          Chronic Active                   |                                                                          |      1  3.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                          |     19  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |     36  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3|             
                                           | 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  +  +  +  M  M  +  +  +  +  A  +  +  M  +  M  +  +  +  +  +  +  M  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                4              3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    3                 X                                            X      |             
      Clear Cell Focus                     |             X     X  1                 X           X              X      |             
      Eosinophilic Focus                   |          3  2     X  2                 3                                 |             
      Fatty Change, Focal                  |                                                                         1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |                X                                                         |             
      Necrosis                             |                                     2                                    |             
      Centrilobular, Cytomegaly            |                                              1  1  1                     |             
      Centrilobular, Fatty Change          |          1                                4  1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinar Cell, Atrophy                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1     1        1     1        1        1     1  1              2   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +              +  +  +                 +           +  +                  |             
      Developmental Malformation           | X              X  X  X                 X           X  X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   | 1           2  3  2  2     1  1        2     1        1  1        2     1|             
      Extra Adrenal Tissue, Inflammation,  |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcapsular, Hyperplasia             | 1  3  1  1  1  3  4  1  1     1     1  1     1  2  2  1  1              2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3|             
                                           | 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3           3     2  2                                            1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Cyst                  |                                        2                                 |             
      Pars Distalis, Hyperplasia           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Focal  |          1                 1           1                             1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                2                                                         |             
      Inflammation, Chronic Active         |                      1           2  1                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Abscess                              |       4                                                                  |             
      Dilatation                           | 3  3     2  4  2  2  2  2  3     3  3  2  2  3     4  1  4  2  2  3     2|             
      Inflammation, Chronic                |                                  2                                       |             
      Inflammation, Chronic Active         | 3        1     2     2  3     4     3                       1  2  1      |             
                                            __________________________________________________________________________|             
   Prostate                                | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         1                    1        1  1        1      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3           2  2     3                 3     2     3  2                 2|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                       +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  M  M  M  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                            2        2                                2   |             
      Hemorrhage                           |    2           2     2           2           2        2              2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    1                    3  3        1                                4   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Atrophy                              | 3  3           2                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3|             
                                           | 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   2                                                      |             
      Inflammation, Chronic Active         |       2           4                                                      |             
      Epidermis, Hyperplasia               |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                           4                              |             
      Mineralization                       |    3  2  2  2  2     1  1  1  1     1  1     2  1  1     2  2     2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3                              |             
      Infiltration Cellular, Lymphocyte    |          1                 1                    2                 1     1|             
      Infiltration Cellular, Histiocyte    |          2                                   2                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          1     2     2                                                   |             
      Bronchiole, Hyperplasia              |          2                                                               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                      1                                                   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |             1  2  2     2  2  2  2  2  1  2  2  2     2  1        1  1   |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Glandular                       |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          1               |             
      Inflammation, Chronic                |             1  1                                               1         |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                                 2        1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 3| 2| 2| 2| 3| 9| 3| 3| 4| 3| 3| 3| 3| 2| 3| 0| 2| 8| 3|             
                                           | 9| 0| 0| 9| 0| 0| 1| 9| 9| 9| 0| 7| 1| 0| 6| 1| 0| 0| 0| 9| 0| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 1  1  2  1  1  1  1  1  2  3  2     1  1  1  2  1  2  2  2  2     1  2  2|             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
      Renal Tubule, Hyperplasia            | 2                    1                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1  1        1                    1  1     1  1     1                     |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3|            |
                                           | 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  M  M  +  +  +  +  +  +  M  M  +  +  +  M  M  M  +  +  +  +|  34        |
      Inflammation, Chronic Active         |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      3  3.0|
      Clear Cell Focus                     |                         X                                                |      7  1.0|
      Eosinophilic Focus                   |                                  1  2                                X   |      8  2.2|
      Fatty Change, Focal                  |                                  1           1                       1   |      4  1.0|
      Hematopoietic Cell Proliferation     |    1        1                                                            |      2  1.0|
      Inflammation, Chronic Active         |    1                          1                                          |      2  1.0|
      Mitotic Alteration                   |          1                                                               |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                               1                                          |      2  1.5|
      Centrilobular, Cytomegaly            |                                                                          |      3  1.0|
      Centrilobular, Fatty Change          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                      1                                                   |      1  1.0|
      Acinar Cell, Atrophy                 |       4           2                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 1  1  1           1           1  1           1  1           1  1  1  1  1|     22  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                  1        1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +              +                                          |   9        |
      Developmental Malformation           |                X              X                                          |      9     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3|            |
                                           | 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hypertrophy, Focal                   |    1  2                                   1  1     2        1  2  1  2  2|     23  1.5|
      Extra Adrenal Tissue, Inflammation,  |                                                                          |            |
           Chronic Active                  |                3                                                         |      1  3.0|
      Subcapsular, Hyperplasia             | 1     1        1        2  2     1     1  1  1        1     1     1  1   |     31  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2                             1                           |      7  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  M  M  M  +  +|  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |             2                                1                           |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia, Focal  |                                     1                    2           1   |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                      2                                                  1|      5  1.4|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                                                                          |      1  4.0|
      Dilatation                           | 4  2  3  3  3  1  4           2  1  4     3  4  3     2     1  1  3  4  4|     40  2.7|
      Inflammation, Chronic                |                      2                                                   |      2  2.0|
      Inflammation, Chronic Active         |    4  4     1     3     1     2  3     1  1  1              1  2     1   |     23  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic                |                   1           1           1  1                 1        1|     11  1.0|
      Inflammation, Chronic Active         |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                             2            |     10  2.4|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +  +     +                          +                        |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  40        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3|            |
                                           | 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |    2                                                     2               |      5  2.0|
      Hemorrhage                           |    4  3           3                                      2  2           2|     13  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    2  1  1  3  3  2           2     3                    3               |     14  2.3|
      Inflammation, Chronic Active         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +|  43        |
      Atrophy                              |                2     4                                                   |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M|   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  4.0|
      Mineralization                       |    2  3     2  3  2     2  2  2     3     2        1  1     1  2  2  2   |     33  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |       1                                               1              1   |      8  1.1|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                               3           3                             1|      6  2.0|
      Bronchiole, Hyperplasia              |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                           2                              |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |    2        1        2                 2  1              2  2            |     23  1.7|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 9| 7| 3| 2| 3| 2| 3| 2| 2| 3| 5| 3| 2| 3| 3| 2| 2| 3| 3|            |
                                           | 0| 1| 9| 7| 9| 0| 3| 9| 0| 9| 1| 9| 0| 9| 9| 1| 0| 0| 9| 1| 0| 9| 9| 1| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Glandular                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +        +                                   +   |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                          +               |   1        |
      Hypertrophy                          |                                                          4               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                1         |      2  1.0|
      Inflammation, Chronic                |          1                    1                          1  1     1      |      8  1.0|
      Inflammation, Chronic Active         |                4                                               1         |      2  2.5|
      Metaplasia, Osseous                  |                                                                          |      2  1.5|
      Nephropathy                          | 1  2  2     1     1  1  1  1  1  1  2  1  1  2     2  1  2  2  1  2  1  2|     45  1.5|
      Renal Tubule, Degeneration, Hyaline  |                      2                                                   |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                   1              1                    1           1     1|     13  1.0|
      Inflammation, Chronic Active         |                4                                                         |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05068-10                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CODEINE                                          Date: 02/24/95  
Route: DOSED FEED                                                                                                 Time: 14:12:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7|             
                             DAY ON TEST   | 9| 2| 3| 9| 2| 3| 3| 0| 3| 3| 3| 3| 2| 1| 3| 2| 3| 2| 3| 2| 7| 3| 2| 5| 3|             
                                           | 6| 9| 0| 7| 9| 1| 1| 3| 1| 1| 0| 0| 9| 6| 1| 5| 1| 9| 1| 9| 4| 1| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    750 PPM                                | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Degeneration, Hyaline                |                      2                                                   |             
      Dilatation                           |                                        2                                 |             
      Inflammation, Chronic                |                      1                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                       2                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                       X                                   X         |             
      Clear Cell Focus                     |                   X                                X                     |             
      Cyst                                 |                                        4                                 |             
      Eosinophilic Focus                   |       2           X                 2        3                           |             
      Fatty Change, Focal                  |                   1                                                      |             
      Infarct                              |             4                          2                                 |             
      Inflammation, Chronic Active         |                         1     1                                          |             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                        3                    2        3   |             
      Pigmentation                         |                                                                          |             
      Centrilobular, Fatty Change          | 2           1                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +     +                        |             
      Fat, Necrosis                        |                                           3     4                        |             
                                            __________________________________________________________________________|             
   Pancreas