TDMS Study 05068-09 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
CODEINE
NTP Experiment-Test: 05068-09 Report: PEIRPT09
Study Type: CHRONIC Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
2 YEAR CORE STUDY
Facility: Microbiological Associates
Chemical CAS #: 76-57-3
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 004 400 PPM
Include 006 800 PPM
Include 008 1600 PPM
Include 001 0 PPM
Include 003 400 PPM
Include 005 800 PPM
Include 007 1600 PPM
Page 1
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|
DAY ON TEST | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|
| 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 2 2 1 3 2 2 2 1 2 2 2 2 3 2 2 |
Clear Cell Focus | 1 1 2 |
Degeneration | 3 |
Developmental Malformation | 2 |
Eosinophilic Focus | |
Fatty Change | 3 2 2 2 2 1|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 2 2 |
Leukocytosis | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Infiltration Cellular, Lymphocyte | |
Fat, Necrosis | 3 3 2 |
Lymphatic, Cyst | |
__________________________________________________________________________|
Oral Mucosa | |
Gingival, Cyst | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | |
Acinar Cell, Atrophy | 2 1 2 2 1 2 2 1 1 2 2 2 |
Acinar Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation | |
Ulcer | 4 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|
DAY ON TEST | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|
| 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 1 1 1 3 |
Valve, Pigmentation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 2 1 1 |
Cytologic Alterations | |
Hypertrophy | 1 |
Vacuolization Cytoplasmic, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + + + + + + + M + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + M + + + + M + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 3 3 3 3 4 |
Pars Distalis, Cyst | 2 2 3 3 2 3|
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + M +|
Ectasia | 2 2 |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Erythroid Cell, Atrophy | 3 |
Erythroid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Cyst | |
Mediastinal, Hemorrhage | 3 2 2 |
Mediastinal, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|
DAY ON TEST | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|
| 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 3 3 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + M + + + M|
Atrophy | 2 2 2 2 1 4 2 3 2 2 2 2 2 |
Congestion | 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | 2 2 2 2 1 |
Lactation | 3 2 2 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | X |
Femur, Hyperostosis | 2 3 |
Turbinate, Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation | 2 3 1 |
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 7| 7| 4| 4| 7| 5|
DAY ON TEST | 7| 3| 3| 8| 3| 2| 3| 3| 3| 1| 3| 8| 3| 3| 7| 8| 3| 3| 1| 3| 3| 3| 7| 3| 9|
| 5| 6| 5| 1| 5| 5| 6| 1| 5| 2| 5| 1| 4| 4| 3| 7| 4| 6| 3| 3| 6| 2| 5| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 7| 8| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation | 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 1 2 3 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
Lens, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Mineralization | 1 1 |
Nephropathy, Chronic | 1 2 2 1 2 2 1 1 2 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9| |
| 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 2 2 2 1 2 1 1 3 2 2 3 3 2 2 2 3 2 1 1 2| 38 1.9|
Clear Cell Focus | 1 2 | 5 1.4|
Degeneration | | 1 3.0|
Developmental Malformation | 2 2 | 3 2.0|
Eosinophilic Focus | 1 3 2 2 2 | 5 2.0|
Fatty Change | 2 1 1 2| 10 1.8|
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hepatodiaphragmatic Nodule | X | 2 |
Infiltration Cellular, Lymphocyte | 2 2 | 2 2.0|
Inflammation | 1 | 4 1.5|
Leukocytosis | | 1 2.0|
Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Fat, Necrosis | 2 2 | 5 2.4|
Lymphatic, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | + + + | 3 |
Gingival, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation | 2 3 | 2 2.5|
Acinar Cell, Atrophy | 2 2 3 2 2 1 1 1 2 2 1 2 | 24 1.7|
Acinar Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 1.7|
Inflammation | 1 2 | 2 1.5|
Ulcer | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9| |
| 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 1 1| 12 1.4|
Valve, Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 2 2 3 2 | 13 1.6|
Cytologic Alterations | 1 | 1 1.0|
Hypertrophy | 2 | 2 1.5|
Vacuolization Cytoplasmic, Focal | 2 2 2 1 | 7 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 2 | 8 1.4|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 |
Pars Distalis, Angiectasis | 2 2 4 3 3 2 | 13 3.0|
Pars Distalis, Cyst | 2 3 3 3 2 3 2 | 13 2.5|
Pars Distalis, Hyperplasia | 2 3 2 1 3 2 | 13 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
Ectasia | 2 3 2 | 5 2.2|
Hyperplasia | 2 2 2 3 2 2 3| 9 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 4 4 2 2 | 7 2.9|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 3 | 3 2.3|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9| |
| 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
Erythroid Cell, Atrophy | | 1 3.0|
Erythroid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Cyst | 3 | 1 3.0|
Mediastinal, Hemorrhage | 2 1 2 | 6 2.0|
Mediastinal, Pigmentation | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 3 | 2 2.5|
Hyperplasia, Plasma Cell | 3 | 2 2.5|
Infiltration Cellular, Histiocyte | | 1 2.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | 1 2 | 5 2.2|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + M + + + + + + + + + + + + + + +| 44 |
Atrophy | 2 2 3 2 3 2 2 2 2 3 2 3 2 2 3 3| 29 2.3|
Congestion | | 1 3.0|
Hemorrhage | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 3.0|
Hyperplasia | 2 2 2 | 8 1.9|
Lactation | 2 2 3 1 2 2 2 2| 14 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | 3 | 2 3.0|
Femur, Hyperostosis | 3 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 5| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 5| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| 8| 4| 3| 9| 3| 3| 3| 3| 7| 3| 8| 3| 4| 3| 9| |
| 3| 4| 3| 4| 6| 4| 4| 3| 5| 3| 9| 7| 5| 0| 6| 5| 4| 3| 7| 4| 6| 4| 8| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Turbinate, Hyperostosis | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 2 3 3 2 2 | 8 2.4|
Hydrocephalus | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 2 2 | 3 1.7|
Infiltration Cellular, Histiocyte | 1 1 1 | 6 1.0|
Inflammation | 1 1 1 1| 7 1.4|
Leukocytosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 2 1.5|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 2 1 1 1 2 1 2 1 1 2 2 2 1 1 1 2 2| 38 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
Lens, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 2.0|
Mineralization | 1 | 3 1.0|
Nephropathy, Chronic | 2 2 2 1 1 2 1 2 1 2 1 2 1 1 2 1 2 1 2 1 1 1 1| 39 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Intussusception | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 2 1 2 1 2 2 1 1 2 2 2 2 2 1 2|
Clear Cell Focus | 1 1 |
Developmental Malformation | |
Eosinophilic Focus | 3 |
Fatty Change | 1 |
Hepatodiaphragmatic Nodule | 2 2 3 |
Infiltration Cellular, Lymphocyte | 1|
Inflammation | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation | 2 |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Acinar Cell, Atrophy | 2 2 1 1 3 2 1 |
Artery, Inflammation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 |
Hypertrophy | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Hyperplasia, Focal | 1 1 2 |
Hypertrophy | 2 |
Vacuolization Cytoplasmic, Focal | 2 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M M M + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 2|
Pars Distalis, Cyst | 2 2 2 2 2 2 |
Pars Distalis, Hyperplasia | 2 2 2 3 2 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Ectasia | 3 3 4 2 2 2 2|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + M + + + + +|
Amyloid Deposition | 3 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 3 2 2 2 2 2 2 2 2 2 3 3 2 3 2|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 3|
Hyperplasia | 2 2 2 1 |
Infiltration Cellular, Histiocyte | 3 |
Lactation | 2 2 3 2 2 2 2 3 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 2 |
Femur, Hyperostosis | 2 2 3 2 |
Turbinate, Hyperostosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 1 3 |
Hemorrhage | 2 3 |
Hydrocephalus | 3 |
Necrosis | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation | 2 1 2|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 2 1 3 2 2 1 1 2 3 2 2 2 2 1 2 2 2 1 1 2 3 2 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 1| 3| 3| 3| 0| 3| 8| 3| 3| 0| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 3| 2| 4| 5| 5| 7| 4| 9| 6| 4| 0| 5| 4| 5| 6| 4| 4| 4| 4| 5| 3| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
400 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 0| 1| 3| 6| 7| 8| 9| 0| 2| 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 3 |
Infiltration Cellular, Lymphocyte | |
Mineralization | 1 |
Nephropathy, Chronic | 2 2 3 1 3 2 2 1 2 2 2 1 2 2 2 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| |
| 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
400 PPM | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Intussusception | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 2 2 1 3 2 1 2 1 2 2 2 2 2 1 2 3 2 3 | 36 1.8|
Clear Cell Focus | 1 1 | 4 1.0|
Developmental Malformation | 2 2 | 2 2.0|
Eosinophilic Focus | 1 | 2 2.0|
Fatty Change | 1 1 1 | 4 1.0|
Hepatodiaphragmatic Nodule | 3 3 | 5 2.6|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Inflammation | | 1 2.0|
Fat, Necrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1| 1 1.0|
Acinar Cell, Atrophy | 1 2 2 2 2 | 12 1.8|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 2 | 4 1.8|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 | 7 1.1|
Hypertrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| |
| 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
400 PPM | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | 1 2 1 2 2 | 6 1.7|
Hyperplasia, Focal | 1 2 1 2 1 1| 9 1.3|
Hypertrophy | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M + + M + + M + M M + + + + M + + + M + +| 37 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 3 2 | 7 2.4|
Pars Distalis, Cyst | 2 2 2 3 3 2 2 2 2 2| 16 2.1|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 3 1 3 2 1 | 18 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 2 | 11 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + M + + + + +| 47 |
Ectasia | 3 3 | 9 2.7|
Hyperplasia | 3 2 3 1 3 | 7 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 5 2.2|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
Mediastinal, Hemorrhage | 3 | 2 2.5|
Mediastinal, Pigmentation | 2 | 2 2.0|
Pancreatic, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| |
| 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
400 PPM | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 1 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + M + + + + + + +| 46 |
Amyloid Deposition | | 1 3.0|
Atrophy | 1 1 2 1 2 2 2 2 1 2 2 2 2 2 | 29 2.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 2 3.0|
Hyperplasia | 2 2 2 | 7 1.9|
Infiltration Cellular, Histiocyte | | 1 3.0|
Lactation | 2 3 2 3 2 2 2 2 3 2 2 | 23 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 2.0|
Subcutaneous Tissue, Cyst Epithelial | | |
Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | 3 | 3 2.3|
Femur, Hyperostosis | 2 2 | 6 2.2|
Turbinate, Hyperostosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 4 2.3|
Hemorrhage | | 2 2.5|
Hydrocephalus | | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| |
| 6| 5| 4| 4| 4| 1| 5| 4| 4| 6| 9| 4| 4| 5| 5| 6| 5| 3| 5| 6| 9| 6| 3| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
400 PPM | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 | 4 1.0|
Inflammation | 1 1 2 1 2 1 | 9 1.4|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 2 2 | 5 1.6|
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 2 2 2 2 2 2 1 1 2 1 1 1 2 2 1 2 1 1 2| 45 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 3 | 3 2.7|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Mineralization | | 1 1.0|
Nephropathy, Chronic | 2 2 2 2 2 1 2 2 1 2 2 1 3 2 1 1 2 2 2 3 1 1| 41 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|
| 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 3 2 2 2 1 1 2 1 2 2 2 1 2 2 1|
Congestion | 1 |
Eosinophilic Focus | |
Fatty Change | 1 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | 2 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 2 1 1 1|
Leukocytosis | |
Mixed Cell Focus | 3 |
Necrosis | |
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 3 2 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation | 2 |
Acinar Cell, Atrophy | 1 1 2 2 2 2 1 2 1|
__________________________________________________________________________|
Pharynx | + |
Palate, Hyperplasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation | |
Ulcer | 3 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1|
Infiltration Cellular, Lymphocyte | |
Atrium, Dilatation | 3 |
Atrium, Thrombosis | |
Coronary Artery, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|
| 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Valve, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 2 |
Cytologic Alterations | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 2 1 1 1 3 |
Necrosis | 3 |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + M + + + + + + + + + + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 4 3 |
Pars Distalis, Cyst | 2 3 2 2 2 4 2 |
Pars Distalis, Hyperplasia | 3 2 2 2 1 2 2 |
Pars Intermedia, Angiectasis | 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 3 |
Hyperplasia | 2 2 2 1 2 2 3 |
Inflammation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2|
Fibrosis | |
Hemorrhage | 4 3 |
__________________________________________________________________________|
Vagina | + |
Inflammation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|
| 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
Renal, Hemorrhage | 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Congestion | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + M + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 3 |
Hyperplasia, Lymphoid | 4 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Atrophy | 2 2 3 2 3 3 2 3 3 1 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Galactocele | 4 |
Hyperplasia | 2 2 3 2 |
Infiltration Cellular, Histiocyte | |
Inflammation | 3 |
Lactation | 2 3 3 2 2 3 3 2 2 1 3 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 |
Femur, Hyperostosis | |
Maxilla, Hyperostosis | |
Turbinate, Hyperostosis | 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 |
Degeneration, Focal | |
Hemorrhage | 2 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 6| 7| 7| 3| 6| 7| 7| 6| 7| 4| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 0| 3| 3| 3| 7| 3| 0| 6| 4| 3| 3| 4| 3| 2| 3| 3| 0| 5| 3| 8| 3| 3| 3| 3|
| 6| 6| 4| 3| 3| 0| 4| 7| 5| 1| 4| 6| 1| 5| 7| 5| 3| 7| 9| 4| 4| 5| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 1| 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Meninges, Inflammation, Focal | |
Meninges, Thrombosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 3 2 |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | 1 1 1|
Inflammation | 2 1 2|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 2 |
Edema, Focal | 2 2 |
Foreign Body | 2 |
Inflammation | 1 2 3 1 1 |
Nasolacrimal Duct, Inflammation | 2 2 |
Olfactory Epithelium, Atrophy, Focal | 2 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 2 2 2 2 2 2 3 2 1 2 2 1 2 2 3 2 2 2 2 2 1 2|
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Hemorrhage | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation | |
__________________________________________________________________________|
Zymbal's Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Infiltration Cellular, Lymphocyte | |
Necrosis | |
Nephropathy, Chronic | 1 2 2 1 2 2 1 2 3 1 2 1 2 2 2 2 2 2 1 2 2|
Bilateral, Hydronephrosis | 4 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|
| 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 2 1 1 1 2 2 2 1 2 2 2 3 |
Congestion | |
Eosinophilic Focus | 2 2 2 |
Fatty Change | 1 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X 3 |
Infiltration Cellular, Lymphocyte | 2 1 |
Inflammation | 1 2 2 1 2 |
Leukocytosis | 2 |
Mixed Cell Focus | |
Necrosis | 2 2 2 |
Centrilobular, Degeneration | 4 |
__________________________________________________________________________|
Mesentery | + +|
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | |
Acinar Cell, Atrophy | 2 1 3 2 1 1 2 1 1 1 1|
__________________________________________________________________________|
Pharynx | |
Palate, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 2 1 2 1 1 1 2 2 |
Infiltration Cellular, Lymphocyte | 3 |
Atrium, Dilatation | |
Atrium, Thrombosis | 2 |
Coronary Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|
| 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Valve, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 1 1 |
Congestion | |
Cytologic Alterations | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Focal | 2 2 |
Necrosis | |
Thrombosis | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 2 2 4 3 |
Pars Distalis, Cyst | 2 2 1 4 4 2 1 3 |
Pars Distalis, Hyperplasia | 1 3 2 2 2 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Ectasia | 2 2 4 |
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 4 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 2 1 |
Fibrosis | |
Hemorrhage | |
__________________________________________________________________________|
Vagina | + |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|
| 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Hemorrhage | 3 2 |
Mediastinal, Pigmentation | 2 2 |
Renal, Hemorrhage | 3 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 2 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Lymphoid | |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + M + + + + + + + + + + M +|
Atrophy | 2 1 3 2 3 3 3 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 4 |
Hyperplasia | 2 3 |
Infiltration Cellular, Histiocyte | 3 3 2 |
Inflammation | |
Lactation | 3 2 2 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 3 3 |
Femur, Hyperostosis | 2 2 3 |
Maxilla, Hyperostosis | 2 |
Turbinate, Hyperostosis | 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 2 3 3 2 |
Degeneration, Focal | 2 |
Hemorrhage | 2 |
Hydrocephalus | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 6| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 8| 7| 9| 3| 4| 0| 3| 3| 7| 3| 6| 3| 3| 3| 3| 2|
| 5| 5| 6| 5| 5| 5| 5| 7| 5| 4| 3| 4| 6| 3| 0| 5| 6| 7| 4| 2| 6| 3| 4| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Meninges, Inflammation, Focal | 2 |
Meninges, Thrombosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 3 |
Inflammation | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Edema, Focal | |
Foreign Body | |
Inflammation | |
Nasolacrimal Duct, Inflammation | 2 |
Olfactory Epithelium, Atrophy, Focal | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 1 1 3 1 2 1 2 1 1 1 1 2 2 1 3 1 1|
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Hemorrhage | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lymphocyte | 1 |
Necrosis | 3 |
Nephropathy, Chronic | 2 1 2 1 3 2 1 2 1 2 2 1 2 2 2 2 1 1 1 |
Bilateral, Hydronephrosis | |
Transitional Epithelium, Hyperplasia,| |
Focal | 1 |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 48 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Basophilic Focus | | 31 1.7|
Congestion | | 1 1.0|
Eosinophilic Focus | | 3 2.0|
Fatty Change | | 4 1.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 4 2.3|
Infiltration Cellular, Lymphocyte | | 2 1.5|
Inflammation | | 10 1.4|
Leukocytosis | | 1 2.0|
Mixed Cell Focus | | 1 3.0|
Necrosis | | 3 2.0|
Centrilobular, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis | | 5 2.4|
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | | 1 2.0|
Acinar Cell, Atrophy | | 20 1.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Hyperplasia | | 3 2.3|
Inflammation | | 1 2.0|
Ulcer | | 4 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Ulcer | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
__________________________________________________________________________|____________|
Heart | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | | 15 1.4|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Atrium, Dilatation | | 1 3.0|
Atrium, Thrombosis | | 1 2.0|
Coronary Artery, Inflammation | | 1 3.0|
Valve, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Angiectasis | | 6 1.3|
Congestion | | 1 2.0|
Cytologic Alterations | | 1 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Focal | | 8 1.8|
Necrosis | | 1 3.0|
Thrombosis | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 50 |
Pars Distalis, Angiectasis | | 10 2.9|
Pars Distalis, Cyst | 2 | 16 2.4|
Pars Distalis, Hyperplasia | | 13 2.0|
Pars Intermedia, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
C-Cell, Hyperplasia | | 5 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 50 |
Ectasia | | 7 2.4|
Hyperplasia | 3 | 8 2.1|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 4 2.3|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Dilatation | | 6 1.7|
Fibrosis | 4 | 1 4.0|
Hemorrhage | | 2 3.5|
__________________________________________________________________________|____________|
Vagina | | 2 |
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Hyperplasia | | 8 2.5|
__________________________________________________________________________|____________|
Lymph Node | + | 9 |
Mediastinal, Hemorrhage | | 2 2.5|
Mediastinal, Pigmentation | | 2 2.0|
Renal, Hemorrhage | | 2 2.5|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Congestion | | 1 2.0|
Hemorrhage | | 4 1.5|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 49 |
Infiltration Cellular, Histiocyte | | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hematopoietic Cell Proliferation | | 5 2.2|
Hyperplasia, Lymphoid | | 1 4.0|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + | 47 |
Atrophy | | 23 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 50 |
Galactocele | | 3 3.7|
Hyperplasia | 2 | 7 2.3|
Infiltration Cellular, Histiocyte | | 3 2.7|
Inflammation | | 1 3.0|
Lactation | | 24 2.3|
__________________________________________________________________________|____________|
Skin | + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Cranium, Hyperostosis | | 3 2.7|
Femur, Hyperostosis | | 3 2.3|
Maxilla, Hyperostosis | | 1 2.0|
Turbinate, Hyperostosis | | 4 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Compression | | 10 2.7|
Degeneration, Focal | | 1 2.0|
Hemorrhage | | 2 2.0|
Hydrocephalus | | 4 2.0|
Meninges, Inflammation, Focal | | 1 2.0|
Meninges, Thrombosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Congestion | | 2 2.5|
Hemorrhage | | 3 2.3|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Infiltration Cellular, Histiocyte | | 7 1.3|
Inflammation | | 4 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + | 51 |
Cytoplasmic Alteration | | 1 2.0|
Edema, Focal | | 2 2.0|
Foreign Body | | 1 2.0|
Inflammation | | 5 1.6|
Nasolacrimal Duct, Inflammation | | 3 2.0|
Olfactory Epithelium, Atrophy, Focal | | 2 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 | 42 1.7|
Respiratory Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
800 PPM | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
Hemorrhage | | 1 3.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Infarct | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Necrosis | | 1 3.0|
Nephropathy, Chronic | | 40 1.7|
Bilateral, Hydronephrosis | | 1 4.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|
| 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 2 2 1 1 1 2 2 1 2 2|
Clear Cell Focus | 1 |
Congestion | 2 |
Developmental Malformation | |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | 3 |
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation | 1 1 |
Leukocytosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Acinar Cell, Atrophy | 1 3 2 1 2 2 2 2 3 2 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Necrosis | 2 2 |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|
| 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 3 |
Cytoplasmic Alteration | 1 2 |
Degeneration | |
Hemorrhage | 2 |
Hyperplasia, Focal | |
Hypertrophy | 1 |
Necrosis | 1 |
Vacuolization Cytoplasmic, Focal | 2 2 1 |
Vacuolization Cytoplasmic | 2 |
Capsule, Inflammation | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Pars Distalis, Angiectasis | 3 2 3 |
Pars Distalis, Cyst | 1 2 2 2 3 |
Pars Distalis, Hyperplasia | 4 2 2 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 2 2 2 2 2 3 2 2 |
Hyperplasia | 2 3 2 |
Inflammation | 2 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 4 |
Inflammation, Granulomatous | |
Corpus Luteum, Hypertrophy | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 1 |
Hemorrhage | 3 |
Endometrium, Hyperplasia | 2 |
__________________________________________________________________________|
Vagina | |
Inflammation | |
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|
| 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 3 3 2 |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Mediastinal, Hemorrhage | 3 2 3 3 |
Mediastinal, Pigmentation | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 1 3 2 |
Hyperplasia, Lymphoid | |
Necrosis | 4 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | 3 2 1 1 2 1 2 3|
Cyst | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2|
Lactation | 2 2 3 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tail, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 3 |
Femur, Hyperostosis | 4 2 |
Turbinate, Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 |
Hemorrhage | 3 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 9| 3| 2| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3|
| 5| 1| 1| 5| 0| 5| 6| 4| 3| 6| 8| 4| 4| 5| 3| 3| 6| 8| 5| 3| 5| 9| 6| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 1|
Inflammation | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 2 1 |
Thrombosis | 2 |
Nares, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 1 2 |
Olfactory Epithelium, Atrophy, Focal | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 2 2 1 1 3 1 2 1 2 1 2 2 1 2 2 2 2 2 2 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 4 |
Phthisis Bulbi | 3 |
Cornea, Inflammation | 4 |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation | 1 |
Mineralization | |
Necrosis | 2 2 |
Nephropathy, Chronic | 1 2 1 3 2 2 1 2 2 2 2 3 2 1 1 1 2 2 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|
| 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 3 3 2 2 2 1 1 1 2 2 1 2 2 1 1 |
Clear Cell Focus | 3 |
Congestion | 2 2 |
Developmental Malformation | 2 |
Eosinophilic Focus | 2 |
Fatty Change | 2 2 1 |
Hepatodiaphragmatic Nodule | |
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 1 1 1 2 2 |
Leukocytosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Acinar Cell, Atrophy | 1 1 1 2 2 1 1 1 2 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Ulcer | 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Necrosis | |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|
| 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 1 2 |
Cytoplasmic Alteration | |
Degeneration | 2 |
Hemorrhage | |
Hyperplasia, Focal | 1 2 1 |
Hypertrophy | |
Necrosis | |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 2 |
Vacuolization Cytoplasmic | 1 |
Capsule, Inflammation | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + M M M + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 3 |
Pars Distalis, Angiectasis | 2 3 2 3 |
Pars Distalis, Cyst | 2 2 3 3 1 3 2 3 2 |
Pars Distalis, Hyperplasia | 1 2 2 3 1 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 3 2 3 2 2 2 3 2|
Hyperplasia | 1 2 2 |
Inflammation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Granulomatous | 3 |
Corpus Luteum, Hypertrophy | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
Hemorrhage | |
Endometrium, Hyperplasia | 2 |
__________________________________________________________________________|
Vagina | + |
Inflammation | 2 |
Prolapse | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|
| 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia | 2 2 2 2|
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + M + +|
Hemorrhage | 1 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia, Lymphoid | 2 |
Necrosis | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + M + + + M +|
Atrophy | 2 2 3 2 2 2 1 1 2 2 3 2 2 3 3|
Cyst | 2 |
Hemorrhage | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 2 |
Lactation | 2 2 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tail, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 3 |
Femur, Hyperostosis | 2 |
Turbinate, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 |
Hemorrhage | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 6| 3| 3| 7| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 0| 1|
| 4| 4| 4| 5| 8| 3| 4| 6| 6| 3| 1| 5| 3| 4| 6| 4| 5| 4| 5| 5| 5| 4| 6| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1600 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
PPM | 8| 9| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 |
Inflammation | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Thrombosis | |
Nares, Hyperplasia | 4 |
Nasolacrimal Duct, Inflammation | 2 |
Olfactory Epithelium, Atrophy, Focal | 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 2 2 3 2 2 2 1 2 1 2 2 2 3 2 2 3 2 2 2 3 1 1 2 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | |
Phthisis Bulbi | |
Cornea, Inflammation | |
Lens, Cataract | 2 2 |
Retina, Degeneration | 4 3 |
__________________________________________________________________________|
Harderian Gland | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation | |
Mineralization | 1 |
Necrosis | |
Nephropathy, Chronic | 2 1 2 1 2 1 2 2 2 1 1 1 2 3 1 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 50 |
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 47 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Basophilic Focus | 1 | 29 1.7|
Clear Cell Focus | | 2 2.0|
Congestion | | 3 2.0|
Developmental Malformation | | 1 2.0|
Eosinophilic Focus | | 1 2.0|
Fatty Change | | 3 1.7|
Hepatodiaphragmatic Nodule | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 2 1.0|
Inflammation | 1 | 9 1.2|
Leukocytosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 3 2.7|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Accessory Spleen | | 1 |
Acinar Cell, Atrophy | | 24 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 50 |
Hyperplasia | | 3 1.3|
Ulcer | | 5 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Fibrosis, Focal | | 1 2.0|
Necrosis | | 2 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
__________________________________________________________________________|____________|
Heart | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | | 9 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Angiectasis | | 3 2.0|
Cytoplasmic Alteration | | 2 1.5|
Degeneration | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | | 3 1.3|
Hypertrophy | | 1 1.0|
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic, Focal | | 8 1.9|
Vacuolization Cytoplasmic | | 2 1.5|
Capsule, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Developmental Malformation | | 1 3.0|
Pars Distalis, Angiectasis | | 7 2.6|
Pars Distalis, Cyst | | 14 2.2|
Pars Distalis, Hyperplasia | | 14 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
C-Cell, Hyperplasia | | 5 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 51 |
Ectasia | | 20 2.3|
Hyperplasia | | 6 2.0|
Inflammation | | 3 3.0|
__________________________________________________________________________|____________|
Ovary | + | 51 |
Cyst | | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Granulomatous | | 1 3.0|
Corpus Luteum, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + | 51 |
Dilatation | | 4 2.3|
Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation | | 1 2.0|
Prolapse | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Hemorrhage | | 1 1.0|
Hyperplasia | | 7 2.3|
Myelofibrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 11 |
Mediastinal, Hemorrhage | | 4 2.8|
Mediastinal, Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 49 |
Hemorrhage | | 3 1.7|
Hyperplasia, Plasma Cell | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 6 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | | 1 4.0|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | M | 46 |
Atrophy | | 23 2.0|
Cyst | | 1 2.0|
Hemorrhage | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Hyperplasia | | 8 2.0|
Lactation | 2 | 16 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + | 51 |
Tail, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Cranium, Hyperostosis | | 3 2.7|
Femur, Hyperostosis | | 3 2.7|
Turbinate, Hyperostosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Compression | | 4 2.3|
Hemorrhage | | 1 3.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Congestion | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Infiltration Cellular, Histiocyte | | 15 1.1|
Inflammation | | 13 1.0|
__________________________________________________________________________|____________|
Nose | + | 51 |
Inflammation | | 4 2.3|
Thrombosis | | 1 2.0|
Nares, Hyperplasia | | 1 4.0|
Nasolacrimal Duct, Inflammation | | 3 1.7|
Olfactory Epithelium, Atrophy, Focal | | 1 2.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 | 49 1.8|
__________________________________________________________________________|____________|
Trachea | + | 51 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
Hemorrhage | | 1 4.0|
Phthisis Bulbi | | 1 3.0|
Cornea, Inflammation | | 1 4.0|
Lens, Cataract | | 2 2.0|
Retina, Degeneration | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
1600 | 7| | L |
PPM | 9| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Cyst | | 1 4.0|
Inflammation | | 1 1.0|
Mineralization | | 1 1.0|
Necrosis | | 2 2.0|
Nephropathy, Chronic | 3 | 40 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|
| 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + A + + + + + + A +|
Diverticulum | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + A + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Atrophy | 2 |
Basophilic Focus | 1 2 2 2 2 |
Clear Cell Focus | 1 |
Congestion | 4 3 |
Degeneration, Cystic | 2 2 2 2 2 |
Developmental Malformation | 2 |
Eosinophilic Focus | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | 3 |
Mixed Cell Focus | 2 |
Necrosis | 3 |
Thrombosis | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 3 3 3 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | 2 2 3 2 1 1 2 2 1 3 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Hyperkeratosis, Focal | |
Necrosis | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|
| 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3|
Atrium, Thrombosis | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1|
Cytologic Alterations | 1 |
Hyperplasia, Focal | 1 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 3 2 4 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M M + M M M + + M + + M +|
Hyperplasia | 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Pars Distalis, Angiectasis | 2 4 3 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Degeneration | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2|
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 4 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Ectasia | |
Hyperplasia | 3 2 |
Inflammation | 2 2 2 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis, Focal | |
Hyperplasia, Focal | |
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 4 3 4 4 3 2 3 2 3 4 4 4 3 4 3 3|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|
| 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 3 |
Bilateral, Atrophy | 3 |
Interstitial Cell, Hyperplasia, Focal| 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 |
Erythroid Cell, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | 2 |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Developmental Malformation | 2 3 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M + + + + + + + + + + + +|
Atrophy | 2 2 2 3 3 3 2 2 3 3 4 2 3 3|
Depletion Cellular | |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + M + + + + M +|
Hyperplasia | 2 |
Lactation | 2 2 2 2 3 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hair Follicle, Atrophy | 3 |
Tail, Acanthosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rib, Developmental Malformation, | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 3| 4| 5| 7| 7| 7| 5| 6| 5| 7| 5| 2| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 4| 9| 2| 3| 3| 2| 8| 6| 3| 5| 0| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 0| 3|
| 4| 6| 9| 0| 3| 2| 5| 4| 7| 2| 4| 3| 9| 2| 3| 2| 6| 2| 0| 2| 2| 3| 3| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 1 1 |
Inflammation | 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 2 3|
Inflammation | 2 3 1 3|
Cartilage, Dysplasia | 2 |
Goblet Cell, Hyperplasia, Focal | |
Nasolacrimal Duct, Inflammation | 2 |
Nasopharyngeal Duct, Metaplasia, | |
Squamous | 2 |
Olfactory Epithelium, Atrophy, Focal | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 1 1 2 |
Olfactory Epithelium, Degeneration | |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Nephropathy, Chronic | 1 2 2 2 3 3 2 1 2 2 2 1 2 1 1 4 1 2 1|
Pigmentation | 3 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
Diverticulum | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 1.7|
Atrophy | | 1 2.0|
Basophilic Focus | 1 2 2 2 2 1 2 2 2 1 1 2| 17 1.7|
Clear Cell Focus | 1 | 2 1.0|
Congestion | | 2 3.5|
Degeneration, Cystic | 1 2 2 2 1 2 2 2 2| 14 1.9|
Developmental Malformation | 2 | 2 2.0|
Eosinophilic Focus | 1 2 2 2 3 3 | 7 2.1|
Fibrosis | 2 2 | 3 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 2 3.0|
Mixed Cell Focus | 2 | 2 2.0|
Necrosis | | 1 3.0|
Thrombosis | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 10 |
Fat, Necrosis | 3 3 3 | 9 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinar Cell, Atrophy | 1 2 2 3 2 1 1 3 2 2 3 | 25 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 3 2.3|
Ulcer | 4 3 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 3.0|
Hyperkeratosis, Focal | 3 | 1 3.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 3 2 2 3 1 2 3 1 3 2 2 2 2 2 2| 32 2.1|
Atrium, Thrombosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 2 | 6 1.3|
Cytologic Alterations | | 1 1.0|
Hyperplasia, Focal | 1 1 | 3 1.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 2 1 3 3 2 2 1 3 2 1 1 2 1| 25 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + + M + + M + + + + + + + + + +| 38 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Pars Distalis, Angiectasis | 2 3 3 2 | 7 2.7|
Pars Distalis, Cyst | 2 | 2 1.5|
Pars Distalis, Degeneration | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 1 2| 5 2.0|
Pars Intermedia, Angiectasis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 | 4 1.8|
Follicle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypospermia | 4 4 4 4 2 4 4 2 4 3 2 4 4 4 4 4 4 2 4 4| 33 3.7|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Ectasia | 2 | 1 2.0|
Hyperplasia | 3 | 3 2.7|
Inflammation | 2 2 2 2 1 3 2| 10 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 3 | 3 2.7|
Fibrosis, Focal | 1 | 1 1.0|
Hyperplasia, Focal | 1 1 1 1 | 4 1.0|
Inflammation | 3 1 1 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 4 3 3 4 4 2 3 3 3 3 3 3 3 4 4 3 4 4 3| 35 3.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 4 2.8|
Bilateral, Atrophy | 3 2 | 3 2.7|
Interstitial Cell, Hyperplasia, Focal| | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2| 5 2.4|
Erythroid Cell, Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 20 |
Mediastinal, Hemorrhage | 2 | 2 2.0|
Mediastinal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Hemorrhage | 2 1 | 3 1.3|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erythrophagocytosis | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Developmental Malformation | 2 | 4 2.0|
Fibrosis | 4 2 | 2 3.0|
Hematopoietic Cell Proliferation | 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + + + + + + + M + + +| 46 |
Atrophy | 2 3 2 2 3 2 3 2 3 3 3 2 3 2| 28 2.6|
Depletion Cellular | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 2 | 3 2.0|
Lactation | 2 2 | 7 2.1|
Pigmentation | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 1 3.0|
Hair Follicle, Atrophy | | 1 3.0|
Tail, Acanthosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Rib, Developmental Malformation, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 1 1| 6 1.0|
Inflammation | 1 3 | 4 1.8|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 1 2.0|
Fungus | 3 | 3 2.7|
Inflammation | 2 4 3 2 2 2 | 10 2.4|
Cartilage, Dysplasia | | 1 2.0|
Goblet Cell, Hyperplasia, Focal | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | | 1 2.0|
Nasopharyngeal Duct, Metaplasia, | | |
Squamous | | 1 2.0|
Olfactory Epithelium, Atrophy, Focal | 2 | 1 2.0|
Olfactory Epithelium, Cytoplasmic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 5| 3| 3| 3| 4| 5| 8| 3| 3| |
| 2| 0| 3| 3| 2| 1| 2| 3| 2| 2| 2| 2| 2| 5| 2| 3| 2| 3| 2| 2| 3| 7| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alteration | 1 1 2 1 1 2 1 1 | 12 1.3|
Olfactory Epithelium, Degeneration | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Nephropathy, Chronic | 1 2 3 2 2 2 2 2 3 2 2 3 2 2 1 2 2 2 2 2 2| 40 2.0|
Pigmentation | | 1 3.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|
| 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 1 1 1 2 2 2 2|
Congestion | |
Degeneration, Cystic | 2 3 2 |
Degeneration | 3 |
Eosinophilic Focus | |
Fatty Change | 3 2 1 2 |
Fibrosis | |
Hepatodiaphragmatic Nodule | |
Infiltration Cellular, Lymphocyte | 2|
Inflammation, Chronic, Focal | |
Necrosis | 4 |
Thrombosis | 2 |
Bile Duct, Cyst | 4 |
Bile Duct, Hyperplasia | 3 3 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + +|
Fat, Necrosis | 3 2 3 3 2 3 3 3 3 2 2 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | |
Necrosis | |
Acinar Cell, Atrophy | 2 3 2 2 1 2 1 2 2 2 3 2 1 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
Hyperplasia | 1 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 3 1 2 2 1 1 2 2 2 2 2 2 2 2 2|
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|
| 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Dilatation | 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 2 1 2 |
Hemorrhage | |
Hyperplasia, Focal | 2 3 2 |
Vacuolization Cytoplasmic, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 2 2 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 1 3 1 1 3 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 2 |
Follicle, Atrophy | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Hypoplasia | |
Hypospermia | 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 3 1 1 2 |
Hyperplasia | 3 |
Inflammation | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +|
Atrophy | 3 2 |
Hemorrhage | |
Hyperplasia, Focal | 1 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|
| 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Depletion Cellular | 2 3 4 4 3 3 3 3 3 2 4 4 3 3 4 3 4 2 3 3 4 3|
Dilatation | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 |
Bilateral, Atrophy | |
Interstitial Cell, Hyperplasia, Focal| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 3 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Erythrophagocytosis | |
Infiltration Cellular, Histiocyte | 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Developmental Malformation | 2 |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Histiocyte | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + M + M + M + + + + + + + M + + + + + + M|
Atrophy | 2 2 3 2 2 3 1 2 2 3 2 2 3 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 2 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Tail, Inflammation | |
Tail, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 2| 3| 2| 5| 3| 3| 3| 3| 4| 3| 3| 3| 2| 7| 3| 5| 0| 3| 3| 3| 3| 2| 3|
| 2| 3| 9| 2| 6| 1| 2| 2| 2| 2| 1| 2| 2| 2| 0| 8| 2| 8| 8| 3| 3| 2| 2| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
400 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hemorrhage | |
Infiltration Cellular, Focal, | |
Histiocyte | 1 |
Inflammation | 1 2 |
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 2 2 3 3|
Inflammation | 2 3 3 1 2 3 3 1 3|
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 2 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 2 1 1 2 2 1 1 1 2 1 1 1 1 1 2 3 1 1 2 2|
Pigmentation | 3 3 3 2 |
Bilateral, Hydronephrosis | |
Glomerulus, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A A + + + + + + + + + + + +| 48 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + A A + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 1 2 2 1 2 2 2 | 17 1.6|
Congestion | 2 | 1 2.0|
Degeneration, Cystic | 2 1 | 5 2.0|
Degeneration | 3 4 | 3 3.3|
Eosinophilic Focus | 2 | 1 2.0|
Fatty Change | 1 | 5 1.8|
Fibrosis | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 2 2 X | 3 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Necrosis | 2 3 | 3 3.0|
Thrombosis | | 1 2.0|
Bile Duct, Cyst | | 1 4.0|
Bile Duct, Hyperplasia | 3 2 | 5 2.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 21 |
Fat, Necrosis | 4 3 2 3 3 3 3 3 | 21 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Liver | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
Acinar Cell, Atrophy | 2 2 2 2 2 2 1 2 2 2 2 2 2| 29 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis, Focal | 3 | 1 3.0|
Hyperplasia | 1 3 | 4 2.0|
Ulcer | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 1 2 2 | 3 1.7|
Ulcer | 2 3 2 2| 4 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2| 24 1.9|
Mineralization, Focal | 2 | 1 2.0|
Atrium, Dilatation | | 1 3.0|
Atrium, Thrombosis | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 7 1.3|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Focal | 1 1 2 | 6 1.8|
Vacuolization Cytoplasmic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 1 2 2 1| 12 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + M + + + + + + + + M + + + + + + + + +| 45 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | 2 2 2| 6 2.2|
Pars Distalis, Hyperplasia, Focal | 2 3 2 2 3 2 | 14 2.1|
Pars Nervosa, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 3 2.0|
Follicle, Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 3.0|
Hypoplasia | 4 | 1 4.0|
Hypospermia | 4 2 4 4 2 4 4 3 4 2 4 4 3 4 4 3| 35 3.7|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 4 2 | 9 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 3.0|
Inflammation | 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 2 4 | 5 2.6|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Focal | | 2 1.5|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Inflammation | 2 1 3 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 3 4 3 4 2 4 4 4 3 3 4 4 4 2 4 4 3 4 3| 41 3.3|
Dilatation | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 2| 4 3.3|
Bilateral, Atrophy | 3 | 1 3.0|
Interstitial Cell, Hyperplasia, Focal| 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hyperplasia | 2 2 3 3 | 8 2.4|
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 17 |
Mediastinal, Hemorrhage | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.0|
Erythrophagocytosis | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 2 2.0|
Developmental Malformation | | 1 2.0|
Fibrosis | 2 | 3 2.0|
Hematopoietic Cell Proliferation | 2 1 3 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + M + + + M + + M + + + +| 41 |
Atrophy | 4 4 3 2 2 2 2 3 2 3 2 2 3| 26 2.4|
Hemorrhage | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Hyperplasia | | 1 2.0|
Pigmentation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 1 4.0|
Tail, Inflammation | 4 | 1 4.0|
Tail, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 2.0|
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 | 1 3.0|
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 1 | 2 1.0|
Inflammation | 1 2 1 | 5 1.4|
Leukocytosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 2.0|
Fungus | | 4 2.5|
Inflammation | 2 2 | 11 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 6| 7| 6| 7| 3| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 5| 5| 6| 6| |
DAY ON TEST | 8| 9| 7| 3| 8| 0| 9| 3| 2| 3| 3| 1| 3| 1| 0| 4| 7| 5| 3| 0| 0| 8| 7| 1| 5| |
| 4| 3| 9| 3| 4| 1| 5| 2| 4| 3| 6| 1| 2| 5| 7| 9| 8| 1| 3| 4| 6| 6| 4| 5| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
400 PPM | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| L |
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 3| 4| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation | 3 | 1 3.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 1 1 1 2 1 1 1 2 1| 16 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 2 1 2 1 2 2 2 3 1 2 2 2 1| 37 1.6|
Pigmentation | 3 2 2 2 | 8 2.5|
Bilateral, Hydronephrosis | 2 | 1 2.0|
Glomerulus, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 2 2 2 2 2 2 1 1|
Clear Cell Focus | 2 |
Degeneration, Cystic | |
Degeneration | 3 |
Developmental Malformation | |
Eosinophilic Focus | 2 1|
Fatty Change | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Chronic, Focal | 1|
Necrosis | 3 |
Thrombosis | 3 2 |
Bile Duct, Fibrosis | 3 |
Bile Duct, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Fat, Necrosis | 4 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Amyloid Deposition | 3 |
Edema | |
Infiltration Cellular, Lymphocyte | 3 |
Acinar Cell, Atrophy | 2 3 2 2 1 2 3 1 2 1 3 2 2 2 1 2|
Artery, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Atrophy | 3 |
Infiltration Cellular, Lymphocyte | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 2 2 2 3 2 2 2 1 2|
Atrium, Dilatation | |
Atrium, Thrombosis | 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 3 1 1|
Hemorrhage | 2 1 |
Hyperplasia, Focal | 1 2 |
Hypertrophy | |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + M M + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Hyperplasia, Focal | 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 4 4 4 4 4 4 4 4 2 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Penis | |
Angiectasis | |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + M + + +|
Depletion Cellular | |
Ectasia | 2 3 |
Hyperplasia | 2 2 |
Inflammation | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 2 |
Dilatation | |
Inflammation | 2 2 1 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 3 4 3 3 4 3 3 4 4 4 3 3 3 4 3 4 3 4 4 3 3 4|
Ectasia | |
Infiltration Cellular, Lymphocyte | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Interstitial Cell, Hyperplasia, Focal| 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia | 1 2 |
Necrosis | 4 |
Erythroid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Pigmentation | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Cyst, Multiple | |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + M + + + + M + + + + + + + + M + + + M + + + +|
Atrophy | 3 4 2 2 1 2 4 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 2 |
Infiltration Cellular, Histiocyte | |
Lactation | |
Pigmentation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation | |
Tail, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Foreign Body | |
Fungus | 3 |
Inflammation | 3 2 3 |
Thrombosis | |
Glands, Dilatation, Focal | |
Nasolacrimal Duct, Inflammation | 3|
Olfactory Epithelium, Atrophy, Focal | |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 1 1 1 1 2 1 1 2 2 2 1 1 2 1|
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lymphocyte | 2 |
Nephropathy, Chronic | 2 2 1 2 2 2 1 2 1 1 1 1 3 2 1 2 2 1 2|
Pigmentation | 2 2 2 3 |
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 6| 7| 6| 6| 7| 5| 6| 7| 7| 5| 6| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 6| 3| 5| 3| 3| 6| 3| 3| 8| 3| 3| 2| 5| 8| 3| 8| 3| 3| 3| 3|
| 0| 3| 6| 2| 3| 7| 2| 8| 8| 2| 5| 4| 2| 0| 8| 3| 2| 9| 7| 2| 7| 2| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 6| 7| 8| 0| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 2 2 1 2 1 2 2 2 2 1 | 21 1.7|
Clear Cell Focus | 2 | 2 2.0|
Degeneration, Cystic | 2 | 1 2.0|
Degeneration | | 1 3.0|
Developmental Malformation | 2 | 1 2.0|
Eosinophilic Focus | 2 2 1 | 5 1.6|
Fatty Change | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X 3 | 2 3.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Chronic, Focal | | 1 1.0|
Necrosis | | 1 3.0|
Thrombosis | 3 2 | 4 2.5|
Bile Duct, Fibrosis | | 1 3.0|
Bile Duct, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 17 |
Fat, Necrosis | 3 3 2 2 3 3 3 3 | 16 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Amyloid Deposition | | 1 3.0|
Edema | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Acinar Cell, Atrophy | 1 1 2 1 2 2 2 1 2 2 1 3 2 | 29 1.8|
Artery, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 3.0|
Atrophy | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | 4 | 1 4.0|
Hyperplasia | 2 | 2 1.5|
Ulcer | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
Ulcer | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 1 2 1 2 2 1 | 25 1.8|
Atrium, Dilatation | 2 | 1 2.0|
Atrium, Thrombosis | 2 2 1 | 5 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 1 3 2 | 11 1.6|
Hemorrhage | 2 | 3 1.7|
Hyperplasia, Focal | | 2 1.5|
Hypertrophy | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 | 10 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 | 3 2.7|
Pars Distalis, Cyst | 2 | 3 2.7|
Pars Distalis, Hyperplasia, Focal | 1 2 | 5 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 1 2 2| 6 1.8|
Follicle, Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hypospermia | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4| 39 3.9|
__________________________________________________________________________|____________|
Penis | + | 1 |
Angiectasis | 3 | 1 3.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Depletion Cellular | 4 | 1 4.0|
Ectasia | 2 2 2 3 | 6 2.3|
Hyperplasia | 3 2 | 4 2.3|
Inflammation | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 2.5|
Dilatation | 3 | 1 3.0|
Inflammation | 2 3 2 | 9 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 3 2 3 3 3 3 3 4 3 3 3 4 3 4 4 3 4| 40 3.4|
Ectasia | 3 2 | 2 2.5|
Infiltration Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Interstitial Cell, Hyperplasia, Focal| 2 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Hyperplasia | 2 3 3 | 5 2.2|
Necrosis | | 1 4.0|
Erythroid Cell, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + +| 14 |
Mediastinal, Hemorrhage | | 2 2.5|
Mediastinal, Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Amyloid Deposition | | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Plasma Cell | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 4.0|
Cyst, Multiple | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | 2 3 | 2 2.5|
Necrosis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + M + M + + + + + + + M + + + + M| 41 |
Atrophy | 3 2 2 3 3 3 2 4 2 3 2 2 3 | 22 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Lactation | 2 2 2 1 | 4 1.8|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation | 2 | 1 2.0|
Tail, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Histiocyte | | 2 1.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation | 2 2 1 | 6 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 | 2 2.5|
Foreign Body | 1 2 | 2 1.5|
Fungus | 3| 2 3.0|
Inflammation | 2 3 2 1 3| 8 2.4|
Thrombosis | 3 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 6| |
DAY ON TEST | 1| 2| 3| 3| 2| 3| 0| 4| 0| 3| 3| 2| 7| 3| 9| 3| 3| 5| 2| 3| 3| 1| 0| 3| 5| |
| 2| 6| 2| 3| 0| 5| 7| 6| 6| 2| 2| 6| 4| 2| 5| 2| 3| 5| 0| 2| 2| 9| 8| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
800 PPM | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
| 3| 4| 5| 6| 7| 9| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Glands, Dilatation, Focal | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | | 1 3.0|
Olfactory Epithelium, Atrophy, Focal | 3 | 1 3.0|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 2 3 1 1 1 1 2 1 2 1| 28 1.4|
Respiratory Epithelium, Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Phthisis Bulbi | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Nephropathy, Chronic | 2 1 2 2 1 2 2 1 1 3 2 1 1 1 2 1 2 | 36 1.6|
Pigmentation | | 4 2.3|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|
| 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1600 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
PPM | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Basophilic Focus | 2 2 2 1 2 1 2 2 1 2 2 |
Clear Cell Focus | |
Degeneration | 4 |
Eosinophilic Focus | 2 3 |
Fatty Change | 2|
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 2 |
Infiltration Cellular, Lymphocyte | |
Leukocytosis | |
Mixed Cell Focus | 2 |
Necrosis | |
Thrombosis | |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 3 3 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | 2 |
Infiltration Cellular, Lymphocyte | |
Acinar Cell, Atrophy | 2 4 2 1 2 2 2 1 4 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 |
Ulcer | 3 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 1 3 2 2 2 2 3 1 1 2|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|
| 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1600 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
PPM | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Dilatation | 3 |
Atrium, Thrombosis | 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 1 1 1 2 2 2 1 1 3 |
Hemorrhage | 3 3|
Hyperplasia, Focal | 2 3 |
Hypertrophy | |
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + M + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + M + + + + M + + + + + + + + +|
Pars Distalis, Angiectasis | 2 4 2 |
Pars Distalis, Cyst | 2 3 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Nervosa, Developmental | |
Malformation | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 4 4 4 2 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 2 |
Hyperplasia | 3 3 3|
Inflammation | 2 2 3 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 2 |
Hyperplasia, Focal | 1 1 |
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 3 3 4 4 4 4 3 3 3 4 3 3 4 3 4 4 4 3 3 4 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|
| 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1600 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
PPM | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 |
Interstitial Cell, Hyperplasia, Focal| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | 1 |
Myelofibrosis | |
Erythroid Cell, Hyperplasia | 2 2 |
Myeloid Cell, Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Lumbar, Pigmentation | 4|
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | 2 2 |
Pancreatic, Lymphocyte, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
Lymphocyte, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 3 |
Lymphocyte, Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 2 |
Pigmentation | 2 |
Lymphocyte, Hyperplasia | |
__________________________________________________________________________|
Thymus | M + + + + M + + + + M + + + + + + + + M + + M + +|
Atrophy | 2 3 4 2 2 2 4 2 3 3 3 2 2|
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia | 2 |
Lactation | 2 |
Pigmentation | 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
_____________________________________________________________________________________________________________________
| 5| 7| 5| 6| 7| 7| 7| 5| 7| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 4| 8| 0| 0| 3| 8| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3|
| 1| 3| 3| 7| 0| 8| 0| 5| 3| 2| 1| 3| 3| 7| 2| 1| 2| 2| 3| 2| 5| 2| 5| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1600 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
PPM | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 4| 6| 7| 9| 0| 1| 2| 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 2 |
Cerebellum, Necrosis, Focal | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Histiocyte | 1 1 1 |
Inflammation | 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Edema, Focal | |
Fungus | |
Inflammation, Acute | |
Inflammation | 2 1 1 |
Thrombosis | |
Olfactory Epithelium, Atrophy, Focal | 2 3 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | 3 1 1 2 2 3 2 2 2 2 1 2 2 2 2 2 1 2 2 3 2 2 3|
Olfactory Epithelium, Necrosis, Focal| 1 |
Respiratory Epithelium, Cytoplasmic | |
Alteration, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Nephropathy, Chronic | 2 2 1 2 2 2 2 2 2 2 2 2 1 1 1 2 3|
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Basophilic Focus | 2 1 2 2 2 | 16 1.8|
Clear Cell Focus | 2 | 1 2.0|
Degeneration | 2 | 2 3.0|
Eosinophilic Focus | 2 2 | 4 2.3|
Fatty Change | | 1 2.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia, Focal | | 1 2.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Leukocytosis | 2 | 1 2.0|
Mixed Cell Focus | | 1 2.0|
Necrosis | 2 | 1 2.0|
Thrombosis | 3 | 1 3.0|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 17 |
Fat, Necrosis | 2 2 2 2 3 3 3 3 3 | 15 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Liver | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Acinar Cell, Atrophy | 2 2 1 2 2 2 1 2 2 1 1 | 22 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 4 1.3|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 2 2.0|
Ulcer | 2 | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 2 2 2 2 1 1 2| 27 1.9|
Atrium, Dilatation | | 1 3.0|
Atrium, Thrombosis | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 2 1 2 1 1 1 | 20 1.6|
Hemorrhage | | 2 3.0|
Hyperplasia, Focal | 1 2 2| 5 2.0|
Hypertrophy | 1 | 1 1.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 1 | 9 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M M + + + + + + +| 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Angiectasis | | 3 2.7|
Pars Distalis, Cyst | | 2 2.5|
Pars Distalis, Hyperplasia, Focal | 2 2 | 3 2.0|
Pars Nervosa, Developmental | | |
Malformation | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Mediastinum, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Hypospermia | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 | 34 3.9|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Ectasia | 3 3 | 4 2.3|
Hyperplasia | 2 3 2 3 2 3 2 3 | 11 2.6|
Inflammation | 3 2 3 | 9 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration | | 1 2.0|
Hyperplasia, Focal | | 2 1.0|
Inflammation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 2 4 3 4 4 3 3 4 4 4 4 3 3 2 2 4 4 4 3 4| 42 3.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Interstitial Cell, Hyperplasia, Focal| 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hyperplasia | | 1 1.0|
Myelofibrosis | 2 | 1 2.0|
Erythroid Cell, Hyperplasia | 2 | 3 2.0|
Myeloid Cell, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 22 |
Lumbar, Pigmentation | | 1 4.0|
Mediastinal, Hemorrhage | 2 | 2 2.5|
Mediastinal, Pigmentation | | 2 2.0|
Pancreatic, Lymphocyte, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Plasma Cell | 2 | 2 2.0|
Lymphocyte, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Pigmentation | | 1 3.0|
Lymphocyte, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Pigmentation | | 1 2.0|
Lymphocyte, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + + M + + + + M + + + + + +| 41 |
Atrophy | 3 4 3 4 3 3 3 2 3 2 | 23 2.8|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | | 1 2.0|
Hyperplasia | | 1 2.0|
Lactation | 2 | 2 2.0|
Pigmentation | 2 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 2.0|
Hemorrhage | | 1 2.0|
Cerebellum, Necrosis, Focal | 2| 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Histiocyte | | 3 1.0|
Inflammation | 1 2 1 2 1 2 | 10 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Edema, Focal | 2 | 1 2.0|
Fungus | 2 | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation | 2 2 | 5 1.6|
Thrombosis | 2 | 1 2.0|
Olfactory Epithelium, Atrophy, Focal | | 2 2.5|
Olfactory Epithelium, Cytoplasmic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05068-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CODEINE Date: 08/29/94
Route: DOSED FEED Time: 22:00:01
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 6| 7| 7| 7| 5| 6| 3| 7| 6| 5| 5| 5| 6| 7| 4| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 9| 0| 8| 5| 3| 2| 3| 5| 7| 5| 1| 5| 3| 5| 4| 8| 3| 8| 3| 3| 7| 3| 3| 3| 0| |
| 4| 1| 3| 9| 2| 9| 2| 0| 0| 5| 5| 9| 0| 9| 4| 3| 3| 4| 3| 3| 0| 2| 2| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
1600 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alteration | 3 2 1 2 2 2 2 3 2 2 2 2 2 1 2 2 1 3 2 2 2 2 2 2| 47 2.0|
Olfactory Epithelium, Necrosis, Focal| 2 | 2 1.5|
Respiratory Epithelium, Cytoplasmic | | |
Alteration, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Nephropathy, Chronic | 1 2 2 1 2 1 1 2 2 3 2 1 2 1 2| 32 1.8|
Pigmentation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
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---------- END OF REPORT ----------
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