TDMS Study 05069-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE NTP Experiment-Test: 05069-06 Report: PEIRPT03 Study Type: INIT/PROMOT Date: 10/19/93 Route: DERMAL,SOLUTION Time: 13:41:28 Facility: TSI Mason Research Chemical CAS #: 147-47-7 Lock Date: 09/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 011 ACETONE/ACETONE Include 004 ACET/TMQ5 MG/KG Include 005 ACET/TMQ10 MG/KG Include 006 ACET/TMQ25 MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93 Route: DERMAL,SOLUTION Time: 13:41:28 ____________________________________________________________________________________________________________________________________ SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ ACETONE 5 MG/KG 10 MG/KG 25 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 30 30 30 30 Early Deaths Natural Death 1 1 2 Moribund Sacrifice 2 1 Survivors Terminal Sacrifice 27 29 29 27 Natural Death 1 Animals Examined Microscopically 30 30 30 30 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (30) (30) (30) (30) Angiectasis 1 (3%) Congestion 1 (3%) 2 (7%) 1 (3%) Eosinophilic Focus 1 (3%) Hematopoietic Cell Proliferation 7 (23%) 4 (13%) 6 (20%) 6 (20%) Inflammation, Chronic 2 (7%) 2 (7%) 1 (3%) Necrosis 2 (7%) 1 (3%) Pigmentation 2 (7%) Periportal, Fibrosis 1 (3%) Salivary Glands (1) Interlobular, Edema 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93 Route: DERMAL,SOLUTION Time: 13:41:28 ____________________________________________________________________________________________________________________________________ SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ ACETONE 5 MG/KG 10 MG/KG 25 MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (1) (1) (1) Cyst 1 (100%) 1 (100%) Hematocyst 1 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (1) (1) Hematopoietic Cell Proliferation 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (30) (30) (30) (30) Back, Acanthosis 1 (3%) 3 (10%) 1 (3%) Back, Inflammation, Chronic 3 (10%) 1 (3%) Back, Inflammation, Chronic Active 1 (3%) Inguinal, Inflammation, Chronic 2 (7%) 1 (3%) 3 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (1) (1) (1) Cyst 1 (100%) 1 (100%) Inflammation, Chronic Active 1 (100%) Nephropathy 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93 Route: DERMAL,SOLUTION Time: 13:41:28 ____________________________________________________________________________________________________________________________________ SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ ACETONE 5 MG/KG 10 MG/KG 25 MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Cortex, Mineralization 1 (100%) Papilla, Necrosis 1 (100%) Renal Tubule, Degeneration, Hyaline 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------