TDMS Study 05069-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-06 Report: PEIRPT03
Study Type: INIT/PROMOT Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:17
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 09/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 011 ACETONE/ACETONE
Include 010 ACETONE/TPA
Include 007 TMQ/TPA
Include 008 DMBA/TPA
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:17
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SENCAR MICE FEMALE ACETONE/ ACETONE/ TMQ/TPA DMBA/TPA
ACETONE TPA
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DISPOSITION SUMMARY
Animals Initially In Study 30 30 30 30
Early Deaths
Moribund Sacrifice 2 4 5 18
Natural Death 1 3
Survivors
Terminal Sacrifice 27 25 25 9
Natural Death 1
Animals Examined Microscopically 30 30 30 30
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ALIMENTARY SYSTEM
Gallbladder (1)
Dilatation 1 (100%)
Liver (30) (30) (30) (30)
Angiectasis 1 (3%)
Congestion 1 (3%) 1 (3%) 1 (3%)
Developmental Malformation 2 (7%)
Eosinophilic Focus 1 (3%)
Hematopoietic Cell Proliferation 7 (23%) 12 (40%) 12 (40%) 17 (57%)
Inflammation, Chronic 2 (7%) 2 (7%) 4 (13%)
Necrosis 2 (7%) 4 (13%)
Pigmentation 2 (7%) 1 (3%) 3 (10%) 1 (3%)
Periportal, Fibrosis 1 (3%)
Mesentery (1)
Cyst 1 (100%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:17
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACETONE/ TMQ/TPA DMBA/TPA
ACETONE TPA
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (1) (2) (1) (7)
Cyst 1 (50%) 1 (100%) 6 (86%)
Cyst, Multiple 1 (14%)
Hematocyst 1 (100%) 1 (50%)
Uterus (1) (1) (5)
Hyperplasia, Cystic 1 (100%) 4 (80%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1) (2) (1)
Axillary, Hyperplasia, Lymphoid 1 (100%) 1 (100%)
Axillary, Infiltration Cellular, 1 (100%) 1 (100%)
Plasma Cell
Spleen (1) (1) (7)
Hematopoietic Cell Proliferation 1 (100%) 7 (100%)
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INTEGUMENTARY SYSTEM
Skin (30) (30) (30) (30)
Back, Acanthosis 30 (100%) 30 (100%) 29 (97%)
Back, Inflammation, Chronic 19 (63%) 15 (50%) 10 (33%)
Back, Inflammation, Chronic Active 5 (17%) 4 (13%) 15 (50%)
Back, Ulcer 4 (13%) 4 (13%) 7 (23%)
Back, Ulcer, Multiple 1 (3%)
Inguinal, Acanthosis 1 (3%) 1 (3%)
Inguinal, Inflammation, Chronic 2 (7%) 1 (3%) 2 (7%) 2 (7%)
Subcutaneous Tissue, Edema 1 (3%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (1) (2) (1)
Infiltration Cellular, Lymphocyte 1 (100%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93
Route: DERMAL,SOLUTION Time: 13:12:17
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACETONE/ TMQ/TPA DMBA/TPA
ACETONE TPA
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1) (1)
Inflammation, Chronic Active 1 (100%)
Papilla, Necrosis 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
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