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TDMS Study 05069-06 Pathology Tables

                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-06                                                                                     Report: PEIRPT03
Study Type: INIT/PROMOT                                                                                           Date: 10/27/93
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:17




       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  09/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 011    ACETONE/ACETONE
                               Include 010    ACETONE/TPA
                               Include 007    TMQ/TPA
                               Include 008    DMBA/TPA





























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1
NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:17    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE              ACETONE/        ACETONE/       TMQ/TPA           DMBA/TPA                                  
                                          ACETONE         TPA                                                                        
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                30              30             30                30                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                       2               4              5                18                                     
    Natural Death                                            1                                3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                      27              25             25                 9                                     
    Natural Death                            1                                                                                      

  Animals Examined Microscopically          30              30             30                30                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                                             (1)                                                      
      Dilatation                                                            1 (100%)                                                
   Liver                                    (30)            (30)           (30)              (30)                                   
      Angiectasis                                                           1 (3%)                                                  
      Congestion                             1 (3%)          1 (3%)                           1 (3%)                                
      Developmental Malformation                                            2 (7%)                                                  
      Eosinophilic Focus                     1 (3%)                                                                                 
      Hematopoietic Cell Proliferation       7 (23%)        12 (40%)       12 (40%)          17 (57%)                               
      Inflammation, Chronic                                  2 (7%)         2 (7%)            4 (13%)                               
      Necrosis                                                              2 (7%)            4 (13%)                               
      Pigmentation                           2 (7%)          1 (3%)         3 (10%)           1 (3%)                                
      Periportal, Fibrosis                   1 (3%)                                                                                 
   Mesentery                                                                                 (1)                                    
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             





                                                             Page    2                                                              
NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:17    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE             ACETONE/         ACETONE/       TMQ/TPA          DMBA/TPA                                   
                                         ACETONE          TPA                                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                   (1)              (2)            (1)              (7)                                     
      Cyst                                                   1 (50%)        1 (100%)         6 (86%)                                
      Cyst, Multiple                                                                         1 (14%)                                
      Hematocyst                            1 (100%)         1 (50%)                                                                
   Uterus                                                   (1)            (1)              (5)                                     
      Hyperplasia, Cystic                                    1 (100%)                        4 (80%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                               (1)            (2)              (1)                                     
      Axillary, Hyperplasia, Lymphoid                        1 (100%)                        1 (100%)                               
      Axillary, Infiltration Cellular,                       1 (100%)                        1 (100%)                               
      Plasma Cell
   Spleen                                  (1)                             (1)              (7)                                     
      Hematopoietic Cell Proliferation      1 (100%)                                         7 (100%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                    (30)             (30)           (30)             (30)                                    
      Back, Acanthosis                                      30 (100%)      30 (100%)        29 (97%)                                
      Back, Inflammation, Chronic                           19 (63%)       15 (50%)         10 (33%)                                
      Back, Inflammation, Chronic Active                     5 (17%)        4 (13%)         15 (50%)                                
      Back, Ulcer                                            4 (13%)        4 (13%)          7 (23%)                                
      Back, Ulcer, Multiple                                                                  1 (3%)                                 
      Inguinal, Acanthosis                                   1 (3%)                          1 (3%)                                 
      Inguinal, Inflammation, Chronic       2 (7%)           1 (3%)         2 (7%)           2 (7%)                                 
      Subcutaneous Tissue, Edema                                                             1 (3%)                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                                     (1)            (2)              (1)                                     
      Infiltration Cellular, Lymphocyte                                                      1 (100%)                               
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             




                                                             Page    3                                                              
NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:17    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE              ACETONE/        ACETONE/       TMQ/TPA       DMBA/TPA                                      
                                          ACETONE         TPA                                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                   (1)                            (1)                                                      
      Inflammation, Chronic Active           1 (100%)                                                                               
      Papilla, Necrosis                      1 (100%)                                                                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             







































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