TDMS Study 05069-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE NTP Experiment-Test: 05069-06 Report: PEIRPT03 Study Type: INIT/PROMOT Date: 10/27/93 Route: DERMAL,SOLUTION Time: 13:18:19 Facility: TSI Mason Research Chemical CAS #: 147-47-7 Lock Date: 09/17/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 009 DMBA/ ACETONE Include 001 DMBA/TMQ5 MG/KG Include 002 DMBA/TMQ10 MG/KG Include 003 DMBA/TMQ25 MG/KG Include 008 DMBA/TPA a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93 Route: DERMAL,SOLUTION Time: 13:18:19 ____________________________________________________________________________________________________________________________________ SENCAR MICE FEMALE DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ DMBA/TPA ACETONE 5 MG/KG 10 MG/KG 25 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 30 30 30 30 30 Early Deaths Moribund Sacrifice 2 1 2 1 18 Natural Death 1 1 2 3 Survivors Terminal Sacrifice 26 28 28 26 9 Natural Death 1 1 Animals Examined Microscopically 30 30 30 30 30 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (1) (1) Dilatation 1 (100%) 1 (100%) Liver (30) (30) (30) (30) (30) Congestion 1 (3%) 1 (3%) 1 (3%) Fatty Change 1 (3%) Hematopoietic Cell Proliferation 8 (27%) 5 (17%) 6 (20%) 5 (17%) 17 (57%) Hepatodiaphragmatic Nodule 1 (3%) Hyperplasia 1 (3%) Inflammation 1 (3%) Inflammation, Acute 1 (3%) 1 (3%) Inflammation, Chronic 5 (17%) 4 (13%) 3 (10%) 3 (10%) 4 (13%) Necrosis 3 (10%) 3 (10%) 4 (13%) Pigmentation 2 (7%) 3 (10%) 4 (13%) 2 (7%) 1 (3%) Centrilobular, Atrophy 1 (3%) Kupffer Cell, Hyperplasia 1 (3%) Portal, Fibrosis 1 (3%) Mesentery (1) Cyst 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93 Route: DERMAL,SOLUTION Time: 13:18:19 ____________________________________________________________________________________________________________________________________ SENCAR MICE FEMALE DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ DMBA/TPA ACETONE 5 MG/KG 10 MG/KG 25 MG/KG ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (2) (1) (1) (7) Abscess 1 (50%) Cyst 1 (50%) 1 (100%) 1 (100%) 6 (86%) Cyst, Multiple 1 (14%) Uterus (1) (5) Hemorrhage 1 (100%) Hyperplasia, Cystic 4 (80%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (2) (1) (1) (1) (1) Axillary, Hyperplasia, Lymphoid 1 (100%) Axillary, Infiltration Cellular, 1 (100%) Plasma Cell Pancreatic, Cyst 1 (100%) Pancreatic, Hyperplasia 1 (100%) Spleen (2) (1) (1) (2) (7) Hematopoietic Cell Proliferation 1 (50%) 1 (100%) 1 (50%) 7 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (30) (30) (30) (30) (30) Back, Acanthosis 1 (3%) 1 (3%) 3 (10%) 29 (97%) Back, Inflammation, Chronic 2 (7%) 10 (33%) Back, Inflammation, Chronic Active 15 (50%) Back, Ulcer 1 (3%) 7 (23%) Back, Ulcer, Multiple 1 (3%) Inguinal, Acanthosis 1 (3%) 1 (3%) Inguinal, Inflammation, Chronic 1 (3%) 2 (7%) Subcutaneous Tissue, Edema 1 (3%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/27/93 Route: DERMAL,SOLUTION Time: 13:18:19 ____________________________________________________________________________________________________________________________________ SENCAR MICE FEMALE DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ DMBA/TPA ACETONE 5 MG/KG 10 MG/KG 25 MG/KG ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (1) (1) Infiltration Cellular, Lymphocyte 1 (100%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (1) Renal Tubule, Degeneration, Hyaline 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------