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TDMS Study 05069-06 Pathology Tables

                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-06                                                                                     Report: PEIRPT03
Study Type: INIT/PROMOT                                                                                           Date: 10/27/93
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:19




       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  09/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 009    DMBA/   ACETONE
                               Include 001    DMBA/TMQ5 MG/KG
                               Include 002    DMBA/TMQ10 MG/KG
                               Include 003    DMBA/TMQ25 MG/KG
                               Include 008    DMBA/TPA




























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1
NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:19    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE                   DMBA/       DMBA/TMQ     DMBA/TMQ     DMBA/TMQ     DMBA/TPA                      
                                              ACETONE     5 MG/KG      10 MG/KG     25 MG/KG                                   
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                    30           30           30           30           30                         
  Early Deaths                                                                                                                      
    Moribund Sacrifice                           2            1            2            1           18                         
    Natural Death                                1            1                         2            3                         
  Survivors                                                                                                                         
    Terminal Sacrifice                          26           28           28           26            9                         
    Natural Death                                1                                      1                                      

  Animals Examined Microscopically              30           30           30           30           30                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                  (1)          (1)                                                               
      Dilatation                                 1 (100%)     1 (100%)                                                         
   Liver                                        (30)         (30)         (30)         (30)         (30)                       
      Congestion                                                           1 (3%)       1 (3%)       1 (3%)                    
      Fatty Change                               1 (3%)                                                                        
      Hematopoietic Cell Proliferation           8 (27%)      5 (17%)      6 (20%)      5 (17%)     17 (57%)                   
      Hepatodiaphragmatic Nodule                              1 (3%)                                                           
      Hyperplasia                                                                       1 (3%)                                 
      Inflammation                                                                      1 (3%)                                 
      Inflammation, Acute                                                  1 (3%)       1 (3%)                                 
      Inflammation, Chronic                      5 (17%)      4 (13%)      3 (10%)      3 (10%)      4 (13%)                   
      Necrosis                                                             3 (10%)      3 (10%)      4 (13%)                   
      Pigmentation                               2 (7%)       3 (10%)      4 (13%)      2 (7%)       1 (3%)                    
      Centrilobular, Atrophy                                               1 (3%)                                              
      Kupffer Cell, Hyperplasia                  1 (3%)                                                                             
      Portal, Fibrosis                                        1 (3%)                                                           
   Mesentery                                                                                        (1)                        
      Cyst                                                                                           1 (100%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             







                                                             Page    2                                                              
NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:19    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE                     DMBA/          DMBA/TMQ     DMBA/TMQ     DMBA/TMQ     DMBA/TPA                       
                                                ACETONE        5 MG/KG      10 MG/KG     25 MG/KG                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                          (2)            (1)                       (1)          (7)                         
      Abscess                                      1 (50%)                                                                          
      Cyst                                         1 (50%)        1 (100%)                  1 (100%)     6 (86%)                    
      Cyst, Multiple                                                                                     1 (14%)                    
   Uterus                                                                     (1)                       (5)                         
      Hemorrhage                                                               1 (100%)                                             
      Hyperplasia, Cystic                                                                                4 (80%)                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                     (2)            (1)          (1)          (1)          (1)                         
      Axillary, Hyperplasia, Lymphoid                                                                    1 (100%)                   
      Axillary, Infiltration Cellular,                                                                   1 (100%)                   
      Plasma Cell
      Pancreatic, Cyst                                            1 (100%)                                                          
      Pancreatic, Hyperplasia                                     1 (100%)                                                          
   Spleen                                         (2)            (1)          (1)          (2)          (7)                         
      Hematopoietic Cell Proliferation             1 (50%)        1 (100%)                  1 (50%)      7 (100%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                           (30)           (30)         (30)         (30)         (30)                        
      Back, Acanthosis                             1 (3%)                      1 (3%)       3 (10%)     29 (97%)                    
      Back, Inflammation, Chronic                                                           2 (7%)      10 (33%)                    
      Back, Inflammation, Chronic Active                                                                15 (50%)                    
      Back, Ulcer                                                                           1 (3%)       7 (23%)                    
      Back, Ulcer, Multiple                                                                              1 (3%)                     
      Inguinal, Acanthosis                                                                  1 (3%)       1 (3%)                     
      Inguinal, Inflammation, Chronic                                          1 (3%)                    2 (7%)                     
      Subcutaneous Tissue, Edema                                                                         1 (3%)                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             






                                                             Page    3                                                              
NTP Experiment-Test: 05069-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:19    
____________________________________________________________________________________________________________________________________

         SENCAR MICE FEMALE                       DMBA/         DMBA/TMQ     DMBA/TMQ     DMBA/TMQ     DMBA/TPA                      
                                                  ACETONE       5 MG/KG      10 MG/KG     25 MG/KG                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                             (1)                                                  (1)                        
      Infiltration Cellular, Lymphocyte                                                                   1 (100%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                           (1)                                                                             
      Renal Tubule, Degeneration, Hyaline            1 (100%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             





























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