TDMS Study 05069-06 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-06 Report: PEIRPT05
Study Type: INIT/PROMOT Date: 10/19/93
Route: DERMAL,SOLUTION Time: 18:16:59
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 09/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 011 ACETONE/ACETONE
Include 004 ACET/TMQ5 MG/KG
Include 005 ACET/TMQ10 MG/KG
Include 006 ACET/TMQ25 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93
Route: DERMAL,SOLUTION Time: 18:16:59
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SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 30 30 30 30
Early Deaths
Natural Death 1 1 2
Moribund Sacrifice 2 1
Survivors
Terminal Sacrifice 27 29 29 27
Natural Death 1
Animals Examined Microscopically 30 30 30 30
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ALIMENTARY SYSTEM
Liver (30) (30) (30) (30)
Hepatocellular Adenoma 1 (3%) 1 (3%)
Sarcoma Stromal, Metastatic, Uterus 1 (3%)
Stomach, Forestomach (1)
Squamous Cell Papilloma 1 (100%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (1) (1) (1)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
Uterus (1)
Sarcoma Stromal 1 (100%)
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93
Route: DERMAL,SOLUTION Time: 18:16:59
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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HEMATOPOIETIC SYSTEM
None
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1) (1) (1)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
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NTP Experiment-Test: 05069-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/93
Route: DERMAL,SOLUTION Time: 18:16:59
____________________________________________________________________________________________________________________________________
SENCAR MICE FEMALE ACETONE/ ACET/TMQ ACET/TMQ ACET/TMQ
ACETONE 5 MG/KG 10 MG/KG 25 MG/KG
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TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 1 1 1
Total Primary Neoplasms 1 1 1 1
Total Animals with Benign Neoplasms 1 1 1
Total Benign Neoplasms 1 1 1
Total Animals with Malignant Neoplasms 1
Total Malignant Neoplasms 1
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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