Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3885

TDMS Study 05069-06 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-06                                                                                     Report: PEIRPT05
Study Type: INIT/PROMOT                                                                                           Date: 10/27/93
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28




       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  09/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 011    ACETONE/ACETONE
                               Include 010    ACETONE/TPA
                               Include 007    TMQ/TPA
                               Include 008    DMBA/TPA





























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE             ACETONE/        ACETONE/        TMQ/TPA        DMBA/TPA                                     
                                        ACETONE         TPA                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study               30              30              30             30                                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                      2               4               5             18                                        
    Natural Death                                           1                              3                                        
  Survivors                                                                                                                         
    Terminal Sacrifice                     27              25              25              9                                        
    Natural Death                           1                                                                                       

  Animals Examined Microscopically         30              30              30             30                                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                   (30)            (30)            (30)           (30)                                      
      Hepatocellular Adenoma                1 (3%)          1 (3%)          2 (7%)                                                  
      Sarcoma Stromal, Metastatic, Uterus                                                  1 (3%)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                          (1)                                                      
   Ovary                                   (1)             (2)             (1)            (7)                                       
   Uterus                                                  (1)             (1)            (5)                                       
      Sarcoma Stromal                                                                      1 (20%)                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    








                                                             Page   2                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                   ACETONE/     ACETONE/    TMQ/TPA          DMBA/TPA                                    
                                              ACETONE      TPA                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                 (1)         (2)              (1)                                      
   Lymph Node, Mandibular                                                 (2)                                                       
   Lymph Node, Mesenteric                                                 (2)                                                       
   Spleen                                        (1)                      (1)              (7)                                      
   Thymus                                                                 (1)                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                                                           (1)                                      
      Adenoma                                                                               1 (100%)                                
   Skin                                          (30)         (30)        (30)             (30)                                     
      Back, Squamous Cell Carcinoma                            1 (3%)      1 (3%)          12 (40%)                                 
      Back, Squamous Cell Carcinoma, Multiple                                               8 (27%)                                 
      Back, Squamous Cell Papilloma                            2 (7%)      3 (10%)          5 (17%)                                 
      Back, Squamous Cell Papilloma, Multiple                  1 (3%)      1 (3%)          12 (40%)                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                            (1)                                                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                1 (100%)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                                       (1)         (2)              (1)                                      
      Alveolar/Bronchiolar Carcinoma                           1 (100%)    1 (50%)                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    









                                                             Page   3                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                       ACETONE/    ACETONE/   TMQ/TPA      DMBA/TPA                                     
                                                  ACETONE     TPA                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                            (1)                    (1)                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                  *(30)       *(30)      *(30)           *(30)                                      
      Leukemia Granulocytic                                                  1 (3%)                                                   
      Lymphoma Malignant Lymphocytic                                         1 (3%)                                                   
____________________________________________________________________________________________________________________________________





































                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   4                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:12:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                       ACETONE/     ACETONE/          TMQ/TPA    DMBA/TPA                                        
                                                  ACETONE      TPA                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)          1             4              10            24                                          
     Total Primary Neoplasms                         1             6              10            39                                          
                                                                                                                                    
   Total Animals with Benign Neoplasms               1             3               6            17                                          
     Total Benign Neoplasms                          1             4               6            18                                          
                                                                                                                                    
   Total Animals with Malignant Neoplasms                          2               4            21                                          
     Total Malignant Neoplasms                                     2               4            21                                          
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                         1                             1                                          
     Total Metastatic Neoplasm                                     1                             1                                          
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              



























                                                             Page   5                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------