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TDMS Study 05069-06 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-06                                                                                     Report: PEIRPT05
Study Type: INIT/PROMOT                                                                                           Date: 10/27/93
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:09




       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  09/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 009    DMBA/   ACETONE
                               Include 001    DMBA/TMQ5 MG/KG
                               Include 002    DMBA/TMQ10 MG/KG
                               Include 003    DMBA/TMQ25 MG/KG
                               Include 008    DMBA/TPA




























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:09    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                     DMBA/       DMBA/TMQ     DMBA/TMQ     DMBA/TMQ     DMBA/TPA                          
                                                ACETONE     5 MG/KG      10 MG/KG     25 MG/KG                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                      30          30           30           30           30                             
  Early Deaths                                                                                                                      
    Moribund Sacrifice                             2           1            2            1           18                             
    Natural Death                                  1           1                         2            3                             
  Survivors                                                                                                                         
    Terminal Sacrifice                            26          28           28           26            9                             
    Natural Death                                  1                                     1                                          

  Animals Examined Microscopically                30          30           30           30           30                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                          (30)        (30)         (30)         (30)         (30)                           
      Hemangiosarcoma                                                       1 (3%)                                                  
      Sarcoma, Metastatic, Uncertain Primary Site              1 (3%)                                                               
      Sarcoma Stromal, Metastatic, Uterus                                                             1 (3%)                        
   Salivary Glands                                (1)                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                          (2)         (1)                       (1)          (7)                            
      Sarcoma, Metastatic, Uncertain Primary Site              1 (100%)                                                             
   Uterus                                                                  (1)                       (5)                            
      Sarcoma Stromal                                                                                 1 (20%)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    






                                                             Page   2                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:09    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                      DMBA/          DMBA/TMQ     DMBA/TMQ     DMBA/TMQ     DMBA/TPA                      
                                                 ACETONE        5 MG/KG      10 MG/KG     25 MG/KG                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                      (2)            (1)          (1)          (1)          (1)                        
   Lymph Node, Mandibular                          (1)                         (1)          (1)                                     
   Lymph Node, Mesenteric                          (1)                         (1)          (1)                                     
   Spleen                                          (2)            (1)          (1)          (2)          (7)                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                   (1)                                      (1)          (1)                        
      Adenoacanthoma                                1 (100%)                                                                        
      Adenocarcinoma                                                                         1 (100%)                               
      Adenoma                                                                                             1 (100%)                  
   Skin                                            (30)           (30)         (30)         (30)         (30)                       
      Squamous Cell Carcinoma                                      1 (3%)                                                           
      Back, Squamous Cell Carcinoma                                             1 (3%)                   12 (40%)                   
      Back, Squamous Cell Carcinoma, Multiple                                                             8 (27%)                   
      Back, Squamous Cell Papilloma                                                                       5 (17%)                   
      Back, Squamous Cell Papilloma, Multiple                                                            12 (40%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                            (1)                                                   (1)                        
      Alveolar/Bronchiolar Carcinoma                1 (100%)                                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    









                                                             Page   3                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:09    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                      DMBA/        DMBA/TMQ     DMBA/TMQ     DMBA/TMQ     DMBA/TPA                        
                                                 ACETONE      5 MG/KG      10 MG/KG     25 MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                          (1)                                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                *(30)        *(30)        *(30)        *(30)        *(30)                         
      Lymphoma Malignant Lymphocytic                2 (7%)                                                                          
      Lymphoma Malignant Mixed                                                1 (3%)                                                
      Lymphoma Malignant Undifferentiated Cell                                             1 (3%)                                   
____________________________________________________________________________________________________________________________________




































                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   4                                                               
NTP Experiment-Test: 05069-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: INIT/PROMOT                            1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/27/93    
Route: DERMAL,SOLUTION                                                                                            Time: 13:18:09    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SENCAR MICE FEMALE                     DMBA/      DMBA/TMQ     DMBA/TMQ     DMBA/TMQ     DMBA/TPA                           
                                                ACETONE    5 MG/KG      10 MG/KG     25 MG/KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)     4              1           3           2          24                                
     Total Primary Neoplasms                    4              1           3           2          39                                
                                                                                                                                    
   Total Animals with Benign Neoplasms                                                            17                                
     Total Benign Neoplasms                                                                       18                                
                                                                                                                                    
   Total Animals with Malignant Neoplasms       4              1           3           2          21                                
     Total Malignant Neoplasms                  4              1           3           2          21                                
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                     1                                   1                                
     Total Metastatic Neoplasm                                 2                                   1                                
                                                                                                                                    
   Total Animals with Malignant Neoplasms                      1                                                                    
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              



























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