TDMS Study 05069-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE DATE: 10/22/93
EXPERIMENT: 05069 TEST: 06 TIME: 09:25:18
TEST TYPE: INIT/PROMOT CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95256 ROUTE: DERMAL,SOLUTION NTP C#: 60902B
PATHOLOGIST: M.E.P. GOAD CAS: 147-47-7
MICE(SENCAR)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Brain
Gallbladder
Kidney
Liver
Lung
Ovary
Salivary Glands
Spleen
DATE: 10/22/93 EXPERIMENT: 05069 TEST: 06 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE MICE(SENCAR) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
TERMINAL SACRIFICE AT 54 WEEKS
|==============================================================================|
|DOSE | DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ |
| | ACETONE 5 MG/KG 10 MG/KG 25 MG/KG |
|==============================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 2/30 (7%) 0/30 (0%) 1/30 (3%) 1/30 (3%) |
|ADJUSTED (b) | 7.1% 0.0% 3.3% 3.7% |
|TERMINAL (d) | 1/27 (4%) 0/28 (0%) 0/28 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 339 --- 240 372 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.303N P=0.228N P=0.492N P=0.500N |
|INCIDENTAL TUMOR | P=0.318N P=0.279N P=0.597N P=0.500N |
|LOGISTIC REGRESSION | P=0.335N P=0.261N P=0.572N P=0.501N |
|COCHRAN-ARMITAGE | P=0.410N |
|FISHER EXACT | P=0.246N P=0.500N P=0.500N |
|==============================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 2/30 (7%) 0/30 (0%) 1/30 (3%) 1/30 (3%) |
|ADJUSTED (b) | 7.1% 0.0% 3.3% 3.7% |
|TERMINAL (d) | 1/27 (4%) 0/28 (0%) 0/28 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 339 --- 240 372 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.303N P=0.228N P=0.492N P=0.500N |
|INCIDENTAL TUMOR | P=0.318N P=0.279N P=0.597N P=0.500N |
|LOGISTIC REGRESSION | P=0.335N P=0.261N P=0.572N P=0.501N |
|COCHRAN-ARMITAGE | P=0.410N |
|FISHER EXACT | P=0.246N P=0.500N P=0.500N |
|==============================================================================|
DATE: 10/22/93 EXPERIMENT: 05069 TEST: 06 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE MICE(SENCAR) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
TERMINAL SACRIFICE AT 54 WEEKS
|==============================================================================|
|DOSE | DMBA/ DMBA/TMQ DMBA/TMQ DMBA/TMQ |
| | ACETONE 5 MG/KG 10 MG/KG 25 MG/KG |
|==============================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 5/30 (17%) 2/30 (7%) 3/30 (10%) 2/30 (7%) |
|ADJUSTED (b) | 16.7% 6.7% 10.2% 7.0% |
|TERMINAL (d) | 2/27 (7%) 0/28 (0%) 2/28 (7%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 212 346 240 242 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.137N P=0.205N P=0.348N P=0.227N |
|INCIDENTAL TUMOR | P=0.100N P=0.230N P=0.450N P=0.173N |
|LOGISTIC REGRESSION | P=0.098N P=0.230N P=0.409N P=0.143N |
|COCHRAN-ARMITAGE | P=0.170N |
|FISHER EXACT | P=0.212N P=0.353N P=0.212N |
|==============================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |
|----------- | |
|OVERALL (a) | 5/30 (17%) 2/30 (7%) 3/30 (10%) 2/30 (7%) |
|ADJUSTED (b) | 16.7% 6.7% 10.2% 7.0% |
|TERMINAL (d) | 2/27 (7%) 0/28 (0%) 2/28 (7%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 212 346 240 242 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.137N P=0.205N P=0.348N P=0.227N |
|INCIDENTAL TUMOR | P=0.100N P=0.230N P=0.450N P=0.173N |
|LOGISTIC REGRESSION | P=0.098N P=0.230N P=0.409N P=0.143N |
|COCHRAN-ARMITAGE | P=0.170N |
|FISHER EXACT | P=0.212N P=0.353N P=0.212N |
|==============================================================================|
DATE: 10/22/93 EXPERIMENT: 05069 TEST: 06 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN FEMALE MICE(SENCAR) -- 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
TERMINAL SACRIFICE AT 54 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).