TDMS Study 05069-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) DATE: 04/05/96
EXPERIMENT: 05069 TEST: 06 TIME: 06:12:38
TEST TYPE: INIT/PROMOT CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95256 ROUTE: DERMAL,SOLUTION NTP C#: 60902B
PATHOLOGIST: M.E.P. GOAD CAS: 147-47-7
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 372 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = DMBA/TMQ5 MG/KG |
| ---------------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 346 355 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = DMBA/TMQ10 MG/KG |
| ---------------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 240 313 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = DMBA/TMQ25 MG/KG |
| ---------------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 52 242 365 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 372 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = ACET/TMQ5 MG/KG |
| ---------------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 327 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = ACET/TMQ10 MG/KG |
| ---------------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 119 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = ACET/TMQ25 MG/KG |
| ---------------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 183 276 369 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 372 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = TMQ/TPA |
| --------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 201 213 221 313 326 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 372 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 372 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|DMBA/TMQ5 | 100.0 100.0 100.0 93.3 93.3 93.3 93.3 93.3 93.3 93.3 |
|MG/KG | |
| | |
|DMBA/TMQ10 | 100.0 100.0 96.7 93.3 93.3 93.3 93.3 93.3 93.3 93.3 |
|MG/KG | |
| | |
|DMBA/TMQ25 | 96.7 96.7 93.3 90.0 90.0 90.0 90.0 90.0 90.0 90.0 |
|MG/KG | |
| | |
|ACET/TMQ5 | 100.0 100.0 100.0 96.7 96.7 96.7 96.7 96.7 96.7 96.7 |
|MG/KG | |
| | |
|ACET/TMQ10 | 100.0 96.7 96.7 96.7 96.7 96.7 96.7 96.7 96.7 96.7 |
|MG/KG | |
| | |
|ACET/TMQ25 | 100.0 100.0 96.7 93.3 90.0 90.0 90.0 90.0 90.0 90.0 |
|MG/KG | |
| | |
|TMQ/TPA | 100.0 100.0 90.0 83.3 83.3 83.3 83.3 83.3 83.3 83.3 |
| | |
| | |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 372 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| DMBA/TMQ5 DMBA/TMQ10 DMBA/TMQ25 ACET/TMQ5 ACET/TMQ10 ACET/TMQ25 TMQ/TPA |
| MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 93.3% 93.3% 90.0% 96.7% 96.7% 90.0% 83.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.116 ----- ----- ----- ----- ----- P=0.376 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 350.5 276.5 219.7 327.0 119.0 276.0 254.8 |
|NATURAL DEATHS (C) | ( 4.5) (36.5) (91.0) ( . ) ( . ) (53.7) (26.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 370.6 365.6 356.8 370.5 363.6 362.4 352.5 |
|(STANDARD ERROR) | ( 1.0) ( 4.8) (11.4) ( 1.5) ( 8.4) ( 7.0) ( 9.1) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
KAPLAN-MEIER SURVIVAL CURVES
DMBA/TMQ5 MG/KG = 1
DMBA/TMQ10 MG/KG = 2
DMBA/TMQ25 MG/KG = 3
ACET/TMQ5 MG/KG = 4
ACET/TMQ10 MG/KG = 5
ACET/TMQ25 MG/KG = 6
TMQ/TPA = 7
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.00 +1 3 5 6 7 2 4 1
|
P |
E |
R 96.67 + 3 5 6 7 7 2 6 2 4 1 1 4
C |
E |
N |
T 93.33 + 7 7 3 6 2 1 3 1
|
S |
U |
R 90.00 + 7 7 3 3
V |
I |
V |
A 86.67 + 7 7
L |
|
|
83.33 + 7 7
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 5 10 15 20 25 30 35 40 45 50 55
WEEK
NOTE: 12 obs hidden.
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: TSI Mason Research 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) DATE: 04/05/96
EXPERIMENT: 05069 TEST: 06 TIME: 06:12:38
TEST TYPE: INIT/PROMOT CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-95256 ROUTE: DERMAL,SOLUTION NTP C#: 60902B
PATHOLOGIST: M.E.P. GOAD CAS: 147-47-7
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 372 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = DMBA/TPA |
| --------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 228 228 231 275 281 281 306 311 313 317 |
| 319 323 324 337 341 344 345 347 347 352 |
| 355 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = DMBA/ ACETONE |
| ---------------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 212 281 339 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = ACETONE/TPA |
| --------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 82 275 313 332 364 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 372 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = ACETONE/ACETONE |
| ---------------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 334 365 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 372 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 372 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|DMBA/TPA | 100.0 100.0 90.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 |
| | |
| | |
|DMBA/ | 100.0 100.0 96.7 90.0 90.0 90.0 90.0 90.0 90.0 90.0 |
|ACETONE | |
| | |
|ACETONE/TPA| 96.7 96.7 96.7 83.3 83.3 83.3 83.3 83.3 83.3 83.3 |
| | |
| | |
|ACETONE/ACE|ONE100.0 100.0 100.0 93.3 93.3 93.3 93.3 93.3 93.3 93.3 |
|A | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| DMBA/TPA DMBA/ ACETONE/TPA ACETONE/A|ETONE
| ACETONE A |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 30.0% 90.0% 83.3% 93.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 309.8 277.3 273.2 349.5 |
|NATURAL DEATHS (C) | ( 9.0) (36.7) (49.9) (15.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 328.4 362.5 355.5 370.5 |
|(STANDARD ERROR) | ( 8.2) ( 6.1) (10.2) ( 1.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER)
KAPLAN-MEIER SURVIVAL CURVES
DMBA/TPA = 1
DMBA/ ACETONE = 2
ACETONE/TPA = 3
ACETONE/ACETONE = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1 4
| 3 2 3 2 4 4
|
| 3 2 3 2 4 4
90 + 1 1 3 3 2 2
| 1 1 3 3
P |
E | 3 3
R 80 + 1 1
C | 1 1
E |
N |
T 70 + 1 1
|
S |
U | 1 1
R 60 +
V | 1 1
I |
V |
A 50 + 1 1
L |
|
|
40 +
| 1 1
|
|
30 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 5 10 15 20 25 30 35 40 45 50 55
WEEK
NOTE: 3 obs hidden.