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https://ntp.niehs.nih.gov/go/2832

TDMS Study 05069-07 Pathology Tables

                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE


NTP Experiment-Test: 05069-07                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 10/19/94
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40


                                                           CORE STUDY


       Facility:  TSI Mason Research

       Chemical CAS #:  147-47-7

       Lock Date:  08/05/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    3.6     MG/KG
                               Include 006    6.0     MG/KG
                               Include 008    10.0    MG/KG
                               Include 001    0 MG/KG
                               Include 003    3.6     MG/KG
                               Include 005    6.0     MG/KG
                               Include 007    10.0    MG/KG























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6            7            7            6                                     
    Natural Death                                     10            3            3            4                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           40           40           40                                     
  Animals Examined Microscopically                    50           50           51           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (43)         (47)         (48)         (45)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Large, Colon                             (49)         (50)         (51)         (49)                                   
      Congestion                                                                 1 (2%)                                             
   Intestine Large, Cecum                             (49)         (49)         (50)         (49)                                   
      Congestion                                                                 1 (2%)                                             
      Inflammation, Granulomatous                                                             1 (2%)                                
      Perforation                                                                             1 (2%)                                
   Intestine Small, Jejunum                           (44)         (47)         (51)         (49)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Congestion                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Small, Ileum                             (45)         (49)         (49)         (48)                                   
      Congestion                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (51)         (50)                                   
      Angiectasis                                      1 (2%)                    3 (6%)       1 (2%)                                
      Clear Cell Focus                                 9 (18%)      7 (14%)      5 (10%)      5 (10%)                               
      Congestion                                       1 (2%)                                                                       
      Eosinophilic Focus                              17 (34%)     20 (40%)     19 (37%)     22 (44%)                               
      Hematopoietic Cell Proliferation                              1 (2%)                    2 (4%)                                
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Mixed Cell Focus                                 3 (6%)       2 (4%)       2 (4%)       6 (12%)                               
      Necrosis                                         3 (6%)       2 (4%)                    1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Vacuolization Cytoplasmic                        2 (4%)       4 (8%)                    2 (4%)                                
      Centrilobular, Necrosis                                       2 (4%)                    1 (2%)                                
   Mesentery                                          (9)          (8)          (11)         (8)                                    
      Hyperplasia, Lymphoid                                                      1 (9%)                                             
      Fat, Inflammation, Chronic Active                             1 (13%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    6 (67%)      7 (88%)      9 (82%)      7 (88%)                               
   Pancreas                                           (50)         (50)         (51)         (50)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Chronic                            3 (6%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Acinus, Atrophy                                  2 (4%)       2 (4%)       3 (6%)       1 (2%)                                
      Acinus, Hyperplasia                                                        1 (2%)       1 (2%)                                
      Duct, Cyst                                       1 (2%)       2 (4%)                                                          
   Salivary Glands                                    (50)         (49)         (51)         (50)                                   
      Fibrosis                                         1 (2%)       1 (2%)                                                          
      Acinus, Atrophy                                  1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
   Stomach, Forestomach                               (50)         (50)         (51)         (50)                                   
      Hyperplasia, Squamous                            2 (4%)       2 (4%)       4 (8%)       2 (4%)                                
      Infiltration Cellular, Eosinophil                1 (2%)                                                                       
      Ulcer                                                                      1 (2%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (51)         (50)                                   
      Erosion                                          2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                                                   1 (2%)                                
      Mineralization                                   1 (2%)       4 (8%)       1 (2%)       2 (4%)                                
      Ulcer                                                                                   1 (2%)                                
      Glands, Cyst                                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (51)         (50)                                   
      Cardiomyopathy                                   6 (12%)      6 (12%)     11 (22%)      5 (10%)                               
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                                             1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (48)         (49)         (51)         (50)                                   
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                 2 (4%)                                
      Hypertrophy                                                   1 (2%)                                                          
      Capsule, Hyperplasia                            48 (100%)    49 (100%)    50 (98%)     50 (100%)                              
   Adrenal Medulla                                    (48)         (49)         (49)         (50)                                   
      Hyperplasia                                                   4 (8%)       3 (6%)       2 (4%)                                
   Islets, Pancreatic                                 (49)         (50)         (51)         (50)                                   
      Hyperplasia                                     30 (61%)     26 (52%)     32 (63%)     31 (62%)                               
   Parathyroid Gland                                  (40)         (44)         (45)         (42)                                   
      Cyst                                             1 (3%)                                 1 (2%)                                
   Pituitary Gland                                    (44)         (48)         (47)         (45)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Angiectasis                       1 (2%)                    2 (4%)       4 (9%)                                
      Pars Distalis, Hyperplasia                      22 (50%)     23 (48%)     17 (36%)     20 (44%)                               
      Rathke's Cleft, Hemorrhage                                                 1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Cyst                                             2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic                                                                   1 (2%)                                
      C-Cell, Hyperplasia                              1 (2%)                                                                       
      Follicle, Hypertrophy                                                                   1 (2%)                                
      Follicular Cell, Hyperplasia                    20 (41%)     25 (50%)     25 (50%)     21 (42%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (50)         (50)         (50)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Pigmentation                                     1 (2%)                    2 (4%)       1 (2%)                                
      Arteriole, Inflammation, Chronic                                                        1 (2%)                                
   Ovary                                              (50)         (49)         (50)         (49)                                   
      Angiectasis                                      1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Atrophy                                          1 (2%)                                                                       
      Cyst                                            14 (28%)     11 (22%)     10 (20%)     14 (29%)                               
      Hemorrhage                                       3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Granulomatous                                                             1 (2%)                                
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active                                       1 (2%)                                                                       
      Periovarian Tissue, Necrosis                     3 (6%)       1 (2%)       1 (2%)       1 (2%)                                
   Uterus                                             (50)         (50)         (51)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                      3 (6%)                    2 (4%)                                             
      Dilatation                                       6 (12%)      3 (6%)       1 (2%)       8 (16%)                               
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)                                
      Hyperplasia, Cystic                             42 (84%)     45 (90%)     44 (86%)     47 (94%)                               
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (51)         (50)                                   
      Myelofibrosis                                   11 (22%)     16 (32%)     15 (29%)     13 (26%)                               
   Lymph Node                                         (8)          (4)          (5)          (3)                                    
      Iliac, Angiectasis                               1 (13%)                                                                      
      Iliac, Hemorrhage                                                                       1 (33%)                               
      Pancreatic, Hyperplasia, Lymphoid                             1 (25%)                                                         
   Lymph Node, Mandibular                             (50)         (49)         (51)         (50)                                   
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       1 (2%)                                             
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
   Lymph Node, Mesenteric                             (47)         (48)         (51)         (50)                                   
      Angiectasis                                      2 (4%)                                 3 (6%)                                
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       1 (2%)                                             
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
   Spleen                                             (50)         (50)         (51)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Hematopoietic Cell Proliferation                15 (30%)     11 (22%)     13 (25%)     15 (30%)                               
      Hyperplasia, Lymphoid                            4 (8%)       9 (18%)      3 (6%)       8 (16%)                               
      Lymphoid Follicle, Atrophy                       1 (2%)                                                                       
   Thymus                                             (45)         (46)         (48)         (49)                                   
      Angiectasis                                                                             1 (2%)                                
      Cyst                                                                                    3 (6%)                                
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)         (49)                                   
      Galactocele                                      1 (2%)                                                                       
   Skin                                               (50)         (50)         (51)         (50)                                   
      Acanthosis                                                                 1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Skin, Site of Application, Acanthosis            1 (2%)       1 (2%)                                                          
      Skin, Site of Application, Hyperplasia, Mast                                                                                  
          Cell                                                      1 (2%)                                                          
      Subcutaneous Tissue, Angiectasis                              1 (2%)                                                          
      Subcutaneous Tissue, Congestion                                            1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                 1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Inflammation, Chronic                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)          (1)          (1)          (1)                                    
      Inflammation, Chronic Active                     1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (51)         (50)                                   
      Hydrocephalus                                                              1 (2%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Thalamus, Mineralization                        21 (42%)     18 (36%)     14 (27%)     17 (34%)                               
   Peripheral Nerve                                   (1)                       (2)          (1)                                    
      Demyelination                                    1 (100%)                  2 (100%)     1 (100%)                              
   Spinal Cord                                        (1)                       (2)          (1)                                    
      Demyelination                                    1 (100%)                  2 (100%)                                           
      Axon, Degeneration                                                                      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (51)         (50)                                   
      Hemorrhage                                       3 (6%)       3 (6%)       2 (4%)       7 (14%)                               
      Infiltration Cellular, Histiocyte                2 (4%)       1 (2%)       3 (6%)       3 (6%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                              2 (4%)                    1 (2%)                                
      Bronchiole, Degeneration, Hyaline                1 (2%)                                                                       
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Nose                                               (50)         (49)         (51)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Exudate                                                       2 (4%)       1 (2%)       2 (4%)                                
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                    1 (2%)                                
      Glands, Inflammation, Acute                     17 (34%)     15 (31%)     20 (39%)     12 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (51)         (50)                                   
      Casts Protein                                                                           1 (2%)                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hydronephrosis                                   1 (2%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Infiltration Cellular, Lymphocyte                             2 (4%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Metaplasia, Osseous                                           1 (2%)                    1 (2%)                                
      Nephropathy, Chronic                            33 (66%)     32 (64%)     37 (73%)     36 (72%)                               
      Pigmentation                                     2 (4%)       1 (2%)                                                          
      Renal Tubule, Atrophy                                                                   1 (2%)                                
      Renal Tubule, Degeneration, Hyaline              2 (4%)                                 1 (2%)                                
      Renal Tubule, Necrosis                                        1 (2%)       1 (2%)       2 (4%)                                
   Urinary Bladder                                    (50)         (50)         (51)         (49)                                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Arteriole, Inflammation, Chronic                                                        1 (2%)                                
      Serosa, Inflammation, Acute                                                             1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            8            2           10                                     
    Moribund Sacrifice                                 5            4            7            3                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           37           41           37                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (46)         (47)         (41)                                   
      Hyperplasia                                                                             1 (2%)                                
   Intestine Large, Rectum                            (48)         (49)         (50)         (49)                                   
      Inflammation, Acute                                                                     1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Intestine Large, Cecum                             (48)         (50)         (50)         (46)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
   Intestine Small, Ileum                             (45)         (46)         (47)         (44)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       1 (2%)                                                          
      Basophilic Focus                                                           1 (2%)       3 (6%)                                
      Clear Cell Focus                                24 (48%)     21 (42%)     20 (40%)     28 (56%)                               
      Congestion                                       3 (6%)       1 (2%)                    2 (4%)                                
      Cyst                                                          1 (2%)                    1 (2%)                                
      Eosinophilic Focus                              20 (40%)     21 (42%)     22 (44%)     10 (20%)                               
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Mixed Cell Focus                                 9 (18%)      9 (18%)     12 (24%)     16 (32%)                               
      Necrosis                                         2 (4%)       4 (8%)       2 (4%)       3 (6%)                                
      Vacuolization Cytoplasmic                        1 (2%)                    2 (4%)       1 (2%)                                
   Mesentery                                          (1)                       (2)          (3)                                    
      Inflammation, Granulomatous                                                1 (50%)                                            
      Fat, Necrosis                                    1 (100%)                               1 (33%)                               
   Pancreas                                           (49)         (49)         (50)         (49)                                   
      Inflammation, Chronic                            1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Acinus, Atrophy                                  8 (16%)      4 (8%)       5 (10%)      5 (10%)                               
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Duct, Cyst                                       1 (2%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (49)         (50)         (50)         (48)                                   
      Hyperplasia, Squamous                            4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Ulcer                                            2 (4%)                                                                       
   Stomach, Glandular                                 (48)         (50)         (50)         (48)                                   
      Erosion                                                       1 (2%)       1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Eosinophil                                          1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Mineralization                                                             1 (2%)                                             
   Tooth                                              (21)         (16)         (26)         (13)                                   
      Dysplasia                                       21 (100%)    15 (94%)     26 (100%)    13 (100%)                              
      Inflammation, Chronic Active                                  1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   2 (4%)       7 (14%)      7 (14%)      4 (8%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                 2 (4%)                                
      Mineralization                                   1 (2%)                                                                       
      Valve, Inflammation, Acute                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (49)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Hyperplasia                                      6 (12%)      8 (16%)      6 (12%)      4 (8%)                                
      Hypertrophy                                     23 (47%)     19 (39%)     16 (33%)     17 (34%)                               
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
      Capsule, Hyperplasia                            43 (88%)     43 (88%)     42 (86%)     38 (76%)                               
   Adrenal Medulla                                    (48)         (49)         (49)         (50)                                   
      Hyperplasia                                      2 (4%)                    1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (49)         (49)         (50)         (49)                                   
      Hyperplasia                                     47 (96%)     45 (92%)     48 (96%)     47 (96%)                               
   Pituitary Gland                                    (45)         (43)         (40)         (46)                                   
      Pars Distalis, Cyst                              2 (4%)       2 (5%)       2 (5%)       3 (7%)                                
      Pars Distalis, Hyperplasia                                    1 (2%)       1 (3%)                                             
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Follicle, Dilatation                                          2 (4%)                    1 (2%)                                
      Follicular Cell, Hyperplasia                     8 (16%)      3 (6%)       9 (18%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 (2%)       2 (4%)                    1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Inflammation, Granulomatous                                                             1 (2%)                                
      Spermatocele                                     2 (4%)       1 (2%)                    2 (4%)                                
   Penis                                              (1)                                                                           
      Concretion                                       1 (100%)                                                                     
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Preputial Gland                                    (48)         (50)         (50)         (50)                                   
      Dilatation                                      14 (29%)     11 (22%)     17 (34%)     16 (32%)                               
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                           14 (29%)     18 (36%)     17 (34%)     14 (28%)                               
      Inflammation, Chronic Active                     5 (10%)      2 (4%)       2 (4%)       4 (8%)                                
      Metaplasia, Squamous                             1 (2%)                                                                       
   Prostate                                           (49)         (50)         (50)         (50)                                   
      Concretion                                                                 1 (2%)                                             
      Cyst                                                                                    1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Seminal Vesicle                                    (49)         (50)         (50)         (50)                                   
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                      2 (4%)                                                                       
      Hypertrophy                                      8 (16%)                                                                      
      Inflammation, Chronic                                         1 (2%)       1 (2%)       2 (4%)                                
   Testes                                             (49)         (50)         (50)         (50)                                   
      Giant Cell                                                    1 (2%)                                                          
      Granuloma Sperm                                               1 (2%)                                                          
      Seminiferous Tubule, Degeneration                2 (4%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (50)         (49)                                   
      Granuloma                                                                               1 (2%)                                
      Hyperplasia, Mast Cell                           1 (2%)                                                                       
      Myelofibrosis                                                 1 (2%)       1 (2%)       1 (2%)                                
   Lymph Node, Mandibular                             (49)         (48)         (49)         (48)                                   
      Angiectasis                                                                             1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (48)         (47)         (50)         (47)                                   
      Angiectasis                                      8 (17%)      2 (4%)       1 (2%)       8 (17%)                               
      Hemorrhage                                                    1 (2%)                    2 (4%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Spleen                                             (48)         (49)         (49)         (50)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 7 (15%)      5 (10%)      5 (10%)      8 (16%)                               
      Hyperplasia, Lymphoid                            1 (2%)                                 4 (8%)                                
      Lymphoid Follicle, Atrophy                                    1 (2%)                                                          
      Red Pulp, Atrophy                                1 (2%)                                 1 (2%)                                
   Thymus                                             (39)         (42)         (46)         (40)                                   
      Atrophy                                          1 (3%)                                                                       
      Cyst                                             3 (8%)                    1 (2%)       1 (3%)                                
      Ectopic Parathyroid Gland                                     1 (2%)       1 (2%)                                             
      Hyperplasia                                      1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Acanthosis                                                    1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)       1 (2%)                                                          
      Skin, Site of Application, Acanthosis            1 (2%)       1 (2%)                    1 (2%)                                
      Skin, Site of Application, Hyperkeratosis                                  1 (2%)                                             
      Skin, Site of Application, Ulcer                 1 (2%)                                                                       
      Subcutaneous Tissue, Abscess                     1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                                              1 (2%)                                
      Subcutaneous Tissue, Granuloma                                             1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage                  1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                    2 (4%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Inflammation, Chronic           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (49)                                   
      Vertebra, Inflammation, Chronic Active           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Thalamus, Mineralization                        24 (48%)     24 (48%)     23 (46%)     18 (36%)                               
   Spinal Cord                                                                  (1)                                                 
      Demyelination                                                              1 (100%)                                           
      Gray Matter, Necrosis                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                       4 (8%)       5 (10%)      4 (8%)       4 (8%)                                
      Infiltration Cellular, Histiocyte                8 (16%)      3 (6%)       7 (14%)      6 (12%)                               
      Inflammation, Chronic                                                                   2 (4%)                                
      Metaplasia, Osseous                                                        1 (2%)       1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (6%)       4 (8%)       3 (6%)       6 (12%)                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Exudate                                          1 (2%)       2 (4%)       8 (16%)      3 (6%)                                
      Foreign Body                                                               1 (2%)                                             
      Inflammation, Acute                              1 (2%)       2 (4%)       5 (10%)                                            
      Polyp, Inflammatory                              1 (2%)       1 (2%)       2 (4%)                                             
      Glands, Inflammation, Acute                     22 (44%)     12 (24%)     11 (22%)     13 (26%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                       (1)                                    
      Atrophy                                                       1 (100%)                                                        
      Lens, Cataract                                                                          1 (100%)                              
   Harderian Gland                                    (4)          (5)          (5)          (3)                                    
      Cyst                                             1 (25%)                                                                      
      Inflammation, Granulomatous                      1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                            10 (20%)      8 (16%)      8 (16%)      8 (16%)                               
      Granuloma                                        1 (2%)                                                                       
      Hydronephrosis                                   3 (6%)                    1 (2%)                                             
      Infarct                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Metaplasia, Osseous                                           2 (4%)                    1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05069-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE                           Date: 10/19/94  
Route: DERMAL,SOLUTION                                                                                            Time: 15:36:40  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      3.6          6.0          10.0                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Nephropathy, Acute                                                                      1 (2%)                                
      Nephropathy, Chronic                            45 (90%)     43 (86%)     50 (100%)    46 (92%)                               
      Pigmentation                                                               1 (2%)                                             
      Cortex, Mineralization                          35 (70%)     40 (80%)     45 (90%)     36 (72%)                               
      Renal Tubule, Degeneration, Hyaline              1 (2%)                                 1 (2%)                                
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (50)         (46)                                   
      Calculus Gross Observation                                    1 (2%)       2 (4%)       1 (2%)                                
      Calculus Micro Observation Only                  3 (6%)       2 (4%)       6 (12%)                                            
      Inflammation, Chronic                                         1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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