TDMS Study 05069-07 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-07 Report: PEIRPT03
Study Type: CHRONIC Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:11:55
65 WEEK SSAC
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 08/05/92
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/04/90 - 09/05/90
Treatment Groups: Include 002 0 MG/KG
Include 004 3.6 MG/KG
Include 006 6.0 MG/KG
Include 008 10.0 MG/KG
Include 001 0 MG/KG
Include 003 3.6 MG/KG
Include 005 6.0 MG/KG
Include 007 10.0 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:11:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 9 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 9 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (10) (8) (9) (10)
Crystals 1 (10%)
Inflammation 1 (10%)
Liver (10) (9) (9) (10)
Clear Cell Focus 1 (11%)
Eosinophilic Focus 3 (30%) 2 (22%) 1 (11%)
Hyperplasia 1 (11%)
Infiltration Cellular, Lymphocyte 1 (10%) 1 (11%)
Mesentery (1) (2) (1)
Inflammation, Chronic Active 1 (50%)
Fat, Necrosis 1 (100%) 2 (100%) 1 (100%)
Pancreas (10) (10) (9) (10)
Inflammation, Chronic 1 (10%)
Acinus, Atrophy 1 (10%)
Salivary Glands (10) (10) (9) (10)
Infiltration Cellular, Lymphocyte 3 (30%) 1 (10%) 2 (20%)
Stomach, Forestomach (10) (10) (9) (10)
Cyst 1 (11%)
Stomach, Glandular (10) (10) (9) (10)
Cyst 1 (10%) 1 (10%)
Inflammation, Subacute 1 (10%)
Mineralization 1 (11%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (9) (10)
Cardiomyopathy 5 (50%) 6 (60%) 4 (44%) 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:11:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (9) (10)
Capsule, Accessory Adrenal Cortical Nodule 2 (20%)
Capsule, Hyperplasia 10 (100%) 10 (100%) 8 (89%) 10 (100%)
Islets, Pancreatic (10) (10) (9) (10)
Hyperplasia 2 (20%) 2 (22%)
Pituitary Gland (8) (9) (9) (9)
Pars Distalis, Hyperplasia 1 (11%) 1 (11%) 1 (11%)
Thyroid Gland (10) (10) (9) (10)
Inflammation, Chronic 1 (10%)
Follicle, Hypertrophy 2 (20%) 2 (22%) 1 (10%)
Follicular Cell, Hyperplasia 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (9) (10)
Cyst 4 (40%) 2 (20%) 2 (22%) 2 (20%)
Hemorrhage 1 (10%)
Periovarian Tissue, Necrosis 1 (10%)
Uterus (10) (10) (9) (10)
Dilatation 1 (10%)
Hyperplasia, Cystic, Glandular 9 (90%) 10 (100%) 9 (100%) 9 (90%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (9) (10)
Myelofibrosis 2 (20%) 1 (10%) 1 (11%)
Lymph Node, Mandibular (10) (10) (9) (8)
Hyperplasia, Lymphoid 1 (10%) 1 (13%)
Lymph Node, Mesenteric (10) (9) (8) (10)
Hyperplasia, Lymphoid 1 (10%)
Spleen (10) (10) (9) (10)
Hematopoietic Cell Proliferation 2 (22%)
Hyperplasia, Lymphoid 1 (10%) 1 (10%)
Thymus (9) (10) (9) (10)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:11:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (10) (10) (9) (10)
Mineralization 3 (30%) 4 (40%) 5 (56%) 5 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (9) (10)
Hemorrhage 2 (20%) 3 (33%) 3 (30%)
Hyperplasia, Lymphoid 1 (10%)
Nose (10) (10) (9) (10)
Glands, Inflammation, Acute 6 (60%) 5 (50%) 2 (22%) 3 (30%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (9) (10)
Infarct 1 (11%)
Infiltration Cellular, Lymphocyte 1 (10%)
Inflammation, Chronic 1 (11%)
Metaplasia, Osseous 2 (22%)
Nephropathy 4 (40%) 3 (30%) 4 (44%) 4 (40%)
Cortex, Mineralization 3 (30%) 2 (20%) 3 (33%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:11:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Basophilic Focus 1 (10%)
Clear Cell Focus 1 (10%) 2 (20%)
Congestion 1 (10%)
Eosinophilic Focus 1 (10%)
Fatty Change 5 (50%) 5 (50%) 5 (50%) 6 (60%)
Hematopoietic Cell Proliferation 2 (20%)
Hyperplasia 1 (10%)
Infarct 1 (10%)
Mixed Cell Focus 1 (10%)
Mesentery (2)
Fat, Necrosis 2 (100%)
Pancreas (10) (10) (10) (10)
Inflammation, Chronic 1 (10%)
Inflammation, Chronic Active 1 (10%)
Acinus, Atrophy 2 (20%) 1 (10%)
Acinus, Necrosis 1 (10%)
Salivary Glands (10) (10) (10) (10)
Infiltration Cellular, Lymphocyte 1 (10%)
Mineralization 1 (10%)
Stomach, Forestomach (10) (10) (10) (10)
Cyst 1 (10%)
Stomach, Glandular (10) (10) (10) (10)
Cyst 3 (30%) 1 (10%)
Infiltration Cellular, Polymorphonuclear 1 (10%)
Mineralization 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10)
Cardiomyopathy 4 (40%) 4 (40%) 2 (20%) 6 (60%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:11:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (9)
Cytoplasmic Alteration 1 (10%) 1 (10%) 3 (30%) 3 (33%)
Hyperplasia 1 (10%)
Capsule, Hyperplasia 8 (80%) 10 (100%) 8 (80%) 8 (89%)
Islets, Pancreatic (10) (10) (10) (10)
Hyperplasia 5 (50%) 4 (40%) 5 (50%) 2 (20%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 2 (20%)
Thyroid Gland (10) (10) (10) (10)
Ultimobranchial Cyst 1 (10%)
Follicle, Hypertrophy 2 (20%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10) (10) (9)
Dilatation 1 (10%) 5 (50%) 3 (33%)
Inflammation, Chronic 2 (20%) 4 (40%)
Prostate (10) (9) (10) (10)
Concretion 1 (11%) 1 (10%)
Testes (10) (10) (10) (10)
Mineralization 1 (10%)
Seminiferous Tubule, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Thymus (10) (9) (10) (9)
Cyst 3 (33%) 1 (10%)
Ectopic Parathyroid Gland 1 (11%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Hyperplasia, Mast Cell 1 (10%)
Skin, Site of Application, Acanthosis 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05069-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 10/19/94
Route: DERMAL,SOLUTION Time: 14:11:55
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 3.6 6.0 10.0
MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (10) (10) (10) (9)
Mineralization 4 (40%) 8 (80%) 4 (40%) 6 (67%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 2 (20%) 1 (10%)
Metaplasia, Osseous 1 (10%)
Nose (10) (10) (10) (10)
Glands, Inflammation, Acute 1 (10%) 3 (30%) 3 (30%) 3 (30%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Hydronephrosis 1 (10%)
Infiltration Cellular, Lymphocyte 1 (10%)
Nephropathy 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Cortex, Mineralization 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Renal Tubule, Hyperplasia 1 (10%)
Urinary Bladder (10) (10) (10) (10)
Calculus Gross Observation 1 (10%) 1 (10%)
Calculus Micro Observation Only 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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