TDMS Study 05069-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: TSI Mason Research 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) DATE: 04/03/96 EXPERIMENT: 05069 TEST: 07 TIME: 03:33:54 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-95256 ROUTE: DERMAL,SOLUTION NTP C#: 60902D PATHOLOGIST: DR. VOELKER CAS: 147-47-7 ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: TSI Mason Research 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) DATE: 04/03/96 EXPERIMENT: 05069 TEST: 07 TIME: 03:33:54 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-95256 ROUTE: DERMAL,SOLUTION NTP C#: 60902D PATHOLOGIST: DR. VOELKER CAS: 147-47-7 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 0 MG/KG | | --------------------- | | | | TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 | | | | UNCENSORED DEATHS | | 6 592 603 612 626 638 639 679 695 701 | | 709 | | CENSORED DEATHS | | 456 456 456 456 456 456 456 456 456 456 | | | |--------------------------------------------------------------------------------| | DOSE = 3.6 MG/KG | | ---------------------------- | | | | TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 11 TERMINAL 37 | | | | UNCENSORED DEATHS | | 22 357 400 540 560 588 616 626 640 708 | | 710 724 | | CENSORED DEATHS | | 207 456 456 456 456 456 456 456 456 456 | | 456 | | | |--------------------------------------------------------------------------------| | DOSE = 6.0 MG/KG | | ---------------------------- | | | | TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 | | | | UNCENSORED DEATHS | | 385 553 571 592 603 618 661 661 669 | | CENSORED DEATHS | | 456 456 456 456 456 456 456 456 456 456 | | | ================================================================================== 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 10.0 MG/KG | | ---------------------------- | | | | TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 10 TERMINAL 37 | | | | UNCENSORED DEATHS | | 464 490 515 536 581 582 623 660 676 686 | | 691 722 728 | | CENSORED DEATHS | | 456 456 456 456 456 456 456 456 456 456 | | | ================================================================================== 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 729 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 729 (A) | | | |--------------------------------------------------------------------------------| | | | |0 MG/KG | 98.3 98.3 98.3 98.3 98.3 98.3 98.3 94.3 86.3 78.3 | | | | | | | |3.6 | 98.3 98.3 98.3 96.6 94.9 94.9 92.9 88.8 82.6 76.4 | |MG/KG | | | | | |6.0 | 100.0 100.0 100.0 100.0 98.3 98.3 98.3 90.3 84.3 82.3 | |MG/KG | | | | | |10.0 | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 88.0 84.0 74.0 | |MG/KG | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 0 MG/KG 3.6 6.0 10.0 | | MG/KG MG/KG MG/KG | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 78.3% 76.4% 82.3% 74.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.800 P=0.894 P=0.852N P=0.763 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 590.9 540.9 590.3 611.8 | |NATURAL DEATHS (C) | (59.8) (57.6) (29.1) (25.0) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 658.2 637.2 662.7 658.1 | |(STANDARD ERROR) | (17.2) (19.7) (14.2) (14.3) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 736 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 0 MG/KG | | --------------------- | | | | TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 | | | | UNCENSORED DEATHS | | 388 502 567 630 665 672 675 684 708 709 | | 711 713 714 714 721 729 | | CENSORED DEATHS | | 455 455 455 455 455 455 455 455 455 455 | | | |--------------------------------------------------------------------------------| | DOSE = 3.6 MG/KG | | ---------------------------- | | | | TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 | | | | UNCENSORED DEATHS | | 448 490 560 581 593 659 684 698 699 724 | | CENSORED DEATHS | | 455 455 455 455 455 455 455 455 455 455 | | | |--------------------------------------------------------------------------------| | DOSE = 6.0 MG/KG | | ---------------------------- | | | | TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 | | | | UNCENSORED DEATHS | | 394 446 490 504 628 694 709 717 726 735 | | CENSORED DEATHS | | 28 455 455 455 455 455 455 455 455 455 | | | ================================================================================== 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 736 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 10.0 MG/KG | | ---------------------------- | | | | TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 | | | | UNCENSORED DEATHS | | 493 537 603 638 642 670 684 687 718 719 | | CENSORED DEATHS | | 455 455 455 455 455 455 455 455 455 455 | | | ================================================================================== 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 736 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 736 (A) | | | |--------------------------------------------------------------------------------| | | | |0 MG/KG | 100.0 100.0 100.0 100.0 98.3 98.3 96.3 94.3 90.3 68.2 | | | | | | | |3.6 | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 90.3 88.3 80.3 | |MG/KG | | | | | |6.0 | 100.0 100.0 100.0 100.0 98.3 96.6 92.6 92.6 90.6 80.5 | |MG/KG | | | | | |10.0 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 94.0 90.0 80.0 | |MG/KG | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | 0 MG/KG 3.6 6.0 10.0 | | MG/KG MG/KG MG/KG | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 68.2% 80.3% 80.5% 80.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.215N P=0.302N P=0.265N P=0.281N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 656.4 613.6 604.3 639.1 | |NATURAL DEATHS (C) | (23.6) (29.9) (41.7) (23.8) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 667.9 668.8 660.1 673.0 | |(STANDARD ERROR) | (14.5) (14.5) (18.4) (14.0) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) KAPLAN-MEIER SURVIVAL CURVES 0 MG/KG = 1 3.6 MG/KG = 2 6.0 MG/KG = 3 10.0 MG/KG = 4 ------------------------------------------------------ SPECIES=MICE SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 11 2 3 4 | 1 2 2 3 3 1 | 4 4 | 2 2 4 4 3 3 1 1 P 95 + 2 2 E | 4 4 3 3 11 R | 42 2 4 3 31 1 C | 2 2 E 90 + 44 3 31 1 N | 2 23 3 T | 4 4 | 242 1 4 1 S 85 + 2 2 U | 331 1 R | 2 344 112 3 V | I 80 + 44 11 V | 1 2 1 A | 4 4 L | 2 2 75 + | 4 4 | | 70 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 6 obs hidden. 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE_(MONOMER) KAPLAN-MEIER SURVIVAL CURVES 0 MG/KG = 1 3.6 MG/KG = 2 6.0 MG/KG = 3 10.0 MG/KG = 4 ----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 13 2 4 | 13 2 2 1 | 4 4 | 3 2 1 4 21 4 95 + 3 3 | 21 2 4 1 4 P | 3 2 2 1 1 E | R 90 + 2 3 4 11 3 C | 2112 3 3 E | 4 4 N | 1142 33 T 85 + 33 | 14 14 S | 2 2 3 U | R 80 + 42 32 V | I | V | A 75 + L | | 11 | 70 + 1 1 | 11 | | 65 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 13 obs hidden.