TDMS Study 05069-08 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-08 Report: PEIRPT03
Study Type: CHRONIC Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
CORE STUDY
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 08/21/92
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 19 10 9 9
Natural Death 12 19 19 19
Survivors
Terminal Sacrifice 19 21 22 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (47) (48) (47)
Erosion 1 (2%)
Intestine Large, Rectum (49) (47) (47) (46)
Erosion 1 (2%)
Intestine Large, Cecum (48) (43) (42) (45)
Edema 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (49) (41) (44) (44)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Intestine Small, Ileum (45) (40) (42) (40)
Inflammation, Chronic 1 (3%)
Metaplasia, Osseous 1 (3%)
Ulcer 1 (3%)
Liver (50) (50) (50) (50)
Angiectasis 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Basophilic Focus 35 (70%) 36 (72%) 32 (64%) 30 (60%)
Clear Cell Focus 7 (14%) 7 (14%) 9 (18%) 12 (24%)
Congestion 1 (2%)
Eosinophilic Focus 12 (24%) 16 (32%) 17 (34%) 14 (28%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%)
Hepatodiaphragmatic Nodule 11 (22%) 5 (10%) 6 (12%) 16 (32%)
Inflammation, Chronic 3 (6%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 10 (20%) 6 (12%) 9 (18%) 11 (22%)
Regeneration 1 (2%) 2 (4%)
Centrilobular, Atrophy 1 (2%)
Centrilobular, Necrosis 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 11 (22%) 5 (10%) 6 (12%) 9 (18%)
Midzonal, Vacuolization Cytoplasmic 1 (2%)
Periportal, Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Serosa, Necrosis 1 (2%)
Mesentery (8) (8) (4) (3)
Inflammation, Chronic 1 (13%) 1 (25%)
Metaplasia, Osseous 1 (25%)
Fat, Necrosis 6 (75%) 7 (88%) 2 (50%) 2 (67%)
Pancreas (50) (50) (50) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%)
Acinus, Atrophy 19 (38%) 15 (30%) 14 (28%) 14 (28%)
Acinus, Hyperplasia 1 (2%)
Artery, Thrombosis 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (50) (50) (49) (50)
Diverticulum 1 (2%)
Hyperplasia, Squamous 13 (26%) 10 (20%) 6 (12%) 7 (14%)
Inflammation, Chronic 9 (18%) 6 (12%) 5 (10%) 5 (10%)
Perforation 1 (2%)
Ulcer 10 (20%) 8 (16%) 5 (10%) 5 (10%)
Stomach, Glandular (50) (50) (50) (49)
Erosion 13 (26%) 6 (12%) 6 (12%) 7 (14%)
Hyperplasia 1 (2%)
Mineralization 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 41 (82%) 46 (92%) 43 (86%) 43 (86%)
Mineralization 1 (2%)
Atrium, Thrombosis 3 (6%) 2 (4%) 2 (4%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (2%)
Degeneration 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 7 (14%) 4 (8%) 2 (4%) 5 (10%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic 13 (26%) 12 (24%) 8 (16%) 8 (16%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 8 (16%) 3 (6%) 3 (6%) 3 (6%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Metaplasia, Hepatocyte 1 (2%) 1 (2%)
Parathyroid Gland (44) (50) (49) (48)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Craniopharyngeal Duct, Pars Intermedia,
Hyperplasia 1 (2%)
Pars Distalis, Angiectasis 9 (18%) 13 (26%) 7 (14%) 11 (22%)
Pars Distalis, Cyst 6 (12%) 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia 11 (22%) 13 (26%) 16 (32%) 11 (22%)
Rathke's Cleft, Cyst 1 (2%)
Rathke's Cleft, Hemorrhage 1 (2%)
Thyroid Gland (49) (50) (48) (49)
Hyperplasia 1 (2%)
C-Cell, Hyperplasia 9 (18%) 12 (24%) 11 (23%) 4 (8%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (46) (45) (49)
Cyst 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Hyperplasia 3 (6%) 1 (2%)
Inflammation, Acute 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Inflammation, Chronic 2 (4%)
Metaplasia, Squamous 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 8 (16%) 2 (4%) 5 (10%) 7 (14%)
Bilateral, Cyst 1 (2%) 2 (4%)
Uterus (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Hyperplasia, Cystic 1 (2%)
Inflammation, Chronic 1 (2%)
Vagina (1) (2)
Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Hyperplasia, Reticulum Cell 1 (2%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (13) (10) (7) (1)
Bronchial, Depletion Lymphoid 1 (10%)
Lumbar, Depletion Lymphoid 1 (10%)
Mediastinal, Congestion 1 (8%)
Mediastinal, Ectasia 1 (10%)
Mediastinal, Hemorrhage 3 (30%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (10%) 1 (14%)
Pancreatic, Ectasia 1 (10%)
Pancreatic, Erythrophagocytosis 1 (8%)
Pancreatic, Pigmentation 1 (10%)
Renal, Hemorrhage 1 (8%) 1 (14%)
Lymph Node, Mandibular (50) (50) (50) (50)
Hemorrhage 3 (6%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Plasma Cell 2 (4%) 1 (2%) 1 (2%)
Lymph Node, Mesenteric (50) (49) (50) (50)
Ectasia 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Acute 1 (2%)
Spleen (50) (50) (50) (50)
Congestion 1 (2%)
Fibrosis 6 (12%) 4 (8%) 3 (6%)
Hematopoietic Cell Proliferation 3 (6%) 5 (10%) 6 (12%) 4 (8%)
Pigmentation 1 (2%) 1 (2%)
Capsule, Necrosis 1 (2%)
Thymus (47) (50) (49) (50)
Cyst 1 (2%) 1 (2%)
Ectopic Parathyroid Gland 2 (4%) 1 (2%)
Metaplasia, Osseous 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (49) (49) (50)
Galactocele 2 (4%) 10 (20%) 3 (6%) 5 (10%)
Inflammation, Chronic Active 1 (2%)
Skin (50) (50) (50) (50)
Acanthosis 2 (4%) 1 (2%) 5 (10%) 3 (6%)
Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic 6 (12%) 10 (20%) 8 (16%) 8 (16%)
Necrosis 1 (2%)
Necrosis, Chronic 1 (2%)
Ulcer 1 (2%)
Skin, Site of Application, Acanthosis 1 (2%) 9 (18%) 22 (44%)
Skin, Site of Application, Hyperkeratosis 1 (2%) 7 (14%) 1 (2%)
Skin, Site of Application, Inflammation,
Chronic 1 (2%) 2 (4%) 2 (4%)
Subcutaneous Tissue, Foreign Body 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
Subcutaneous Tissue, Skin, Site of
Application, Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 2 (4%)
Hyperostosis 1 (2%)
Cranium, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Peripheral Nerve (1)
Axon, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Edema 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 5 (10%) 5 (10%) 2 (4%) 3 (6%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%) 3 (6%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%) 2 (4%)
Alveolus, Edema 1 (2%)
Capillary, Thrombosis 1 (2%)
Serosa, Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (50) (50) (50) (49)
Foreign Body 2 (4%) 2 (4%) 2 (4%) 4 (8%)
Fungus 2 (4%) 3 (6%) 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 4 (8%) 6 (12%) 3 (6%) 7 (14%)
Thrombosis 3 (6%) 3 (6%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (3)
Iris, Synechia 1 (50%)
Lens, Cataract 2 (100%) 3 (100%)
Posterior Chamber, Hemorrhage 1 (33%)
Retina, Atrophy 1 (50%)
Retina, Degeneration 1 (50%) 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Accumulation, Hyaline Droplet 4 (8%)
Hydronephrosis 1 (2%)
Infarct 1 (2%)
Inflammation, Acute 1 (2%)
Nephropathy, Chronic 49 (98%) 45 (90%) 48 (96%) 49 (98%)
Pigmentation 2 (4%) 1 (2%) 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (50) (48) (49) (50)
Hemorrhage 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Natural Death 21 26 25 23
Moribund Sacrifice 24 22 20 26
Survivors
Terminal Sacrifice 5 2 4 1
Other 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (47) (42) (44)
Inflammation, Acute 1 (2%)
Ulcer 1 (2%)
Intestine Large, Rectum (47) (49) (49) (45)
Angiectasis 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
Intestine Large, Cecum (42) (44) (36) (39)
Dilatation 1 (2%)
Erosion 1 (2%)
Inflammation, Acute 2 (5%) 7 (16%) 4 (10%)
Necrosis 1 (2%) 1 (2%) 1 (3%)
Ulcer 3 (7%) 2 (5%)
Intestine Small, Duodenum (50) (50) (46) (48)
Diverticulum 1 (2%)
Erosion 2 (4%) 1 (2%)
Inflammation, Chronic Active 2 (4%)
Ulcer 1 (2%)
Intestine Small, Jejunum (46) (45) (42) (39)
Inflammation, Acute 1 (2%)
Intestine Small, Ileum (40) (37) (34) (37)
Diverticulum 1 (3%)
Fibrosis 1 (3%)
Inflammation, Chronic 1 (3%) 1 (3%) 1 (3%)
Metaplasia, Osseous 1 (3%)
Necrosis 1 (3%)
Ulcer 1 (3%)
Liver (50) (50) (50) (50)
Angiectasis 6 (12%) 5 (10%) 1 (2%) 1 (2%)
Basophilic Focus 8 (16%) 4 (8%) 3 (6%) 4 (8%)
Clear Cell Focus 5 (10%) 3 (6%) 3 (6%) 3 (6%)
Congestion 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Degeneration, Cystic 3 (6%) 6 (12%) 7 (14%) 2 (4%)
Eosinophilic Focus 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 8 (16%) 7 (14%) 8 (16%) 4 (8%)
Hyperplasia 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 1 (2%) 3 (6%)
Leukocytosis 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 1 (2%) 4 (8%)
Necrosis 4 (8%) 2 (4%) 3 (6%)
Regeneration 1 (2%) 1 (2%)
Centrilobular, Necrosis 3 (6%) 1 (2%) 2 (4%) 4 (8%)
Centrilobular, Vacuolization Cytoplasmic 12 (24%) 6 (12%) 8 (16%) 7 (14%)
Periportal, Vacuolization Cytoplasmic 4 (8%) 2 (4%) 4 (8%)
Serosa, Fibrosis 1 (2%)
Serosa, Necrosis 1 (2%)
Mesentery (10) (3) (3) (4)
Hemorrhage 2 (20%) 2 (50%)
Inflammation, Chronic 1 (33%)
Inflammation, Granulomatous 1 (10%)
Artery, Angiectasis 1 (25%)
Fat, Necrosis 6 (60%) 2 (67%) 1 (33%) 1 (25%)
Pancreas (50) (50) (50) (50)
Cytoplasmic Alteration 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
Acinus, Atrophy 25 (50%) 21 (42%) 20 (40%) 23 (46%)
Acinus, Hyperplasia 2 (4%) 3 (6%) 4 (8%) 6 (12%)
Artery, Angiectasis 2 (4%) 2 (4%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Artery, Mineralization 1 (2%) 1 (2%)
Salivary Glands (49) (50) (50) (50)
Fibrosis 1 (2%)
Stomach, Forestomach (50) (50) (50) (49)
Erosion 1 (2%)
Foreign Body 1 (2%)
Hyperplasia, Squamous 29 (58%) 34 (68%) 31 (62%) 28 (57%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 17 (34%) 14 (28%) 20 (40%) 14 (29%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%) 5 (10%) 2 (4%)
Perforation 4 (8%) 5 (10%) 7 (14%) 4 (8%)
Ulcer 20 (40%) 25 (50%) 16 (32%) 15 (31%)
Stomach, Glandular (50) (50) (50) (49)
Erosion 13 (26%) 22 (44%) 22 (44%) 17 (35%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Mineralization 15 (30%) 19 (38%) 20 (40%) 16 (33%)
Ulcer 2 (4%) 2 (4%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 47 (94%) 48 (96%) 48 (96%) 44 (88%)
Inflammation, Acute 2 (4%)
Mineralization 10 (20%) 15 (30%) 13 (26%) 9 (18%)
Thrombosis 1 (2%)
Atrium, Inflammation, Acute 2 (4%)
Atrium, Thrombosis 4 (8%) 5 (10%) 9 (18%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Angiectasis 2 (4%)
Cytoplasmic Alteration 2 (4%)
Hemorrhage 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Hyperplasia 2 (4%) 2 (4%) 2 (4%) 5 (10%)
Hypertrophy 1 (2%)
Inflammation, Acute 1 (2%)
Necrosis 2 (4%)
Vacuolization Cytoplasmic 9 (18%) 11 (22%) 11 (22%) 9 (18%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 28 (56%) 33 (66%) 30 (60%) 23 (46%)
Mineralization 1 (2%)
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 4 (8%) 1 (2%) 1 (2%)
Parathyroid Gland (48) (49) (46) (49)
Hyperplasia 18 (38%) 21 (43%) 23 (50%) 23 (47%)
Mineralization 1 (2%) 1 (2%)
Pituitary Gland (49) (50) (50) (49)
Angiectasis 1 (2%) 1 (2%)
Mineralization 1 (2%)
Craniopharyngeal Duct, Hyperplasia 1 (2%)
Craniopharyngeal Duct, Pars Nervosa,
Hyperplasia 1 (2%)
Pars Distalis, Angiectasis 4 (8%) 2 (4%) 4 (8%) 1 (2%)
Pars Distalis, Cyst 3 (6%) 4 (8%) 6 (12%) 8 (16%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 11 (22%) 14 (28%) 12 (24%) 14 (29%)
Pars Distalis, Pigmentation 1 (2%) 2 (4%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 2 (4%) 1 (2%)
Pars Nervosa, Cyst 1 (2%) 1 (2%) 1 (2%)
Rathke's Cleft, Cyst 1 (2%) 2 (4%)
Thyroid Gland (50) (50) (50) (50)
Cyst 1 (2%)
Mineralization 1 (2%)
C-Cell, Hyperplasia 4 (8%) 7 (14%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Mediastinum, Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Atrophy 1 (2%)
Granuloma Sperm 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Penis (6) (10) (2) (2)
Foreign Body 1 (17%)
Inflammation, Acute 2 (33%) 5 (50%) 1 (50%) 1 (50%)
Inflammation, Chronic Active 1 (17%)
Mineralization 1 (10%)
Preputial Gland (50) (49) (49) (49)
Abscess 1 (2%)
Cyst 1 (2%) 2 (4%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Acute 5 (10%) 2 (4%) 5 (10%) 8 (16%)
Inflammation, Chronic 4 (8%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%)
Prostate (50) (50) (50) (49)
Developmental Malformation 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 23 (46%) 28 (56%) 22 (44%) 24 (49%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Seminal Vesicle (50) (50) (50) (50)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 2 (4%) 2 (4%)
Testes (50) (50) (50) (50)
Hemorrhage 1 (2%)
Mineralization 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Arteriole, Inflammation, Chronic 1 (2%)
Interstitial Cell, Hyperplasia 27 (54%) 22 (44%) 25 (50%) 31 (62%)
Seminiferous Tubule, Degeneration 21 (42%) 25 (50%) 26 (52%) 23 (46%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hypoplasia 4 (8%) 2 (4%)
Myelofibrosis 5 (10%)
Necrosis 1 (2%) 1 (2%)
Lymph Node (19) (15) (6) (9)
Mediastinal, Angiectasis 2 (11%)
Mediastinal, Congestion 1 (5%) 1 (11%)
Mediastinal, Ectasia 1 (5%) 2 (13%)
Mediastinal, Erythrophagocytosis 2 (11%) 2 (13%)
Mediastinal, Hemorrhage 1 (5%) 3 (20%) 1 (17%) 1 (11%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (5%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (5%)
Mediastinal, Pigmentation 1 (11%)
Pancreatic, Angiectasis 1 (5%) 1 (7%)
Pancreatic, Congestion 1 (5%)
Pancreatic, Ectasia 1 (7%)
Pancreatic, Hemorrhage 2 (11%) 2 (13%)
Pancreatic, Hyperplasia, Lymphoid 1 (7%)
Pancreatic, Infiltration Cellular, Plasma
Cell 1 (11%)
Pancreatic, Necrosis 1 (5%)
Renal, Ectasia 1 (5%)
Renal, Hemorrhage 1 (11%)
Lymph Node, Mandibular (49) (50) (50) (50)
Ectasia 1 (2%)
Erythrophagocytosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Infiltration Cellular, Plasma Cell 5 (10%) 2 (4%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (49)
Angiectasis 2 (4%) 1 (2%) 2 (4%)
Congestion 1 (2%)
Depletion Lymphoid 1 (2%) 1 (2%) 1 (2%)
Ectasia 5 (10%) 3 (6%) 6 (12%) 3 (6%)
Erythrophagocytosis 2 (4%) 2 (4%) 2 (4%)
Hemorrhage 3 (6%) 5 (10%) 2 (4%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Acute 1 (2%)
Spleen (50) (50) (50) (50)
Fibrosis 11 (22%) 12 (24%) 12 (24%) 13 (26%)
Hematopoietic Cell Proliferation 2 (4%) 7 (14%) 6 (12%) 2 (4%)
Necrosis 2 (4%)
Pigmentation 2 (4%)
Capsule, Necrosis 2 (4%) 4 (8%)
Lymphoid Follicle, Depletion Cellular 1 (2%)
Red Pulp, Thrombosis 1 (2%)
Thymus (45) (44) (49) (46)
Angiectasis 1 (2%)
Ectopic Parathyroid Gland 3 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (42) (45) (40)
Galactocele 12 (29%) 5 (12%) 3 (7%) 2 (5%)
Skin (50) (50) (49) (50)
Acanthosis 9 (18%) 5 (10%) 6 (12%) 7 (14%)
Hyperkeratosis 1 (2%) 1 (2%) 5 (10%)
Inflammation, Acute 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Skin, Site of Application, Acanthosis 1 (2%) 4 (8%) 14 (29%) 21 (42%)
Skin, Site of Application, Cyst Epithelial
Inclusion 1 (2%)
Skin, Site of Application, Hyperkeratosis 2 (4%) 2 (4%) 2 (4%) 3 (6%)
Skin, Site of Application, Inflammation,
Chronic 3 (6%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%) 1 (2%)
Subcutaneous Tissue, Skin, Site of
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Application, Fibrosis 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 21 (42%) 24 (48%) 27 (54%) 25 (50%)
Inflammation, Chronic 1 (2%)
Osteomalacia 1 (2%)
Mandible, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 4 (8%) 2 (4%) 3 (6%) 1 (2%)
Inflammation, Acute 1 (2%)
Cerebrum, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Emphysema 2 (4%)
Hemorrhage 7 (14%) 9 (18%) 5 (10%) 4 (8%)
Infiltration Cellular, Histiocyte 10 (20%) 13 (26%) 15 (30%) 15 (30%)
Inflammation, Acute 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic 3 (6%) 3 (6%)
Inflammation, Chronic Active 1 (2%)
Mineralization 2 (4%) 7 (14%) 6 (12%) 6 (12%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 1 (2%) 1 (2%)
Alveolus, Edema 4 (8%) 3 (6%) 9 (18%) 5 (10%)
Capillary, Thrombosis 4 (8%)
Nose (50) (49) (50) (50)
Foreign Body 15 (30%) 11 (22%) 9 (18%) 9 (18%)
Fungus 19 (38%) 21 (43%) 13 (26%) 10 (20%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 26 (52%) 24 (49%) 22 (44%) 16 (32%)
Thrombosis 2 (4%) 1 (2%)
Ulcer 2 (4%) 4 (8%) 2 (4%)
Vein, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:33:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (3)
Anterior Chamber, Inflammation, Acute 1 (33%)
Choroid, Mineralization 1 (33%)
Cornea, Inflammation, Acute 1 (33%)
Iris, Synechia 1 (33%)
Lens, Cataract 1 (100%) 3 (100%) 3 (100%)
Retina, Degeneration 2 (67%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 13 (26%) 10 (20%) 17 (34%) 20 (40%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%)
Inflammation, Acute 2 (4%)
Mineralization 3 (6%) 2 (4%) 5 (10%) 4 (8%)
Nephropathy, Chronic 50 (100%) 50 (100%) 49 (98%) 50 (100%)
Pigmentation 2 (4%) 1 (2%)
Cortex, Mineralization 1 (2%)
Renal Tubule, Degeneration, Hyaline 1 (2%)
Renal Tubule, Hyperplasia 2 (4%) 6 (12%) 3 (6%)
Vein, Thrombosis 1 (2%)
Urinary Bladder (49) (50) (50) (48)
Calculus Gross Observation 2 (4%) 1 (2%)
Calculus Micro Observation Only 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------