TDMS Study 05069-08 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-08 Report: PEIRPT03
Study Type: CHRONIC Date: 03/13/95
Route: DERMAL,SOLUTION Time: 17:45:22
66 WEEK SSAC
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 08/21/92
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 17:45:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Intestine Small, Ileum (10) (10) (10) (10)
Dilatation 1 (10%)
Erosion 1 (10%)
Liver (10) (10) (10) (10)
Basophilic Focus 9 (90%) 9 (90%) 9 (90%) 7 (70%)
Clear Cell Focus 1 (10%) 2 (20%)
Cyst 1 (10%)
Eosinophilic Focus 1 (10%)
Fatty Change, Focal 1 (10%) 2 (20%)
Hepatodiaphragmatic Nodule 1 (10%) 4 (40%) 1 (10%) 3 (30%)
Mixed Cell Focus 2 (20%) 1 (10%)
Mesentery (1) (1) (1)
Fat, Necrosis 1 (100%) 1 (100%) 1 (100%)
Pancreas (10) (10) (10) (10)
Acinus, Atrophy 3 (30%) 6 (60%) 6 (60%) 4 (40%)
Artery, Inflammation, Chronic Active 1 (10%)
Salivary Glands (10) (10) (10) (10)
Duct, Metaplasia, Squamous 1 (10%) 3 (30%) 1 (10%) 3 (30%)
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 (10%)
Hyperplasia, Basal Cell 1 (10%)
Inflammation, Acute 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10)
Cardiomyopathy 5 (50%) 7 (70%) 7 (70%) 8 (80%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 17:45:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hyperplasia 1 (10%)
Adrenal Medulla (10) (10) (10) (10)
Hyperplasia 1 (10%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Angiectasis 3 (30%) 4 (40%) 6 (60%) 6 (60%)
Pars Distalis, Cyst 6 (60%) 8 (80%) 8 (80%) 7 (70%)
Pars Distalis, Hyperplasia 3 (30%) 6 (60%) 6 (60%) 5 (50%)
Thyroid Gland (10) (10) (10) (10)
C-Cell, Hyperplasia 1 (10%)
Follicle, Cyst 2 (20%)
Follicular Cell, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Cyst 1 (10%) 2 (20%) 1 (10%)
Uterus (10) (10) (10) (10)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Inflammation, Chronic 3 (30%) 1 (10%) 1 (10%)
Skin, Site of Application, Acanthosis 1 (10%) 4 (40%) 4 (40%) 8 (80%)
Skin, Site of Application, Hyperkeratosis 1 (10%) 1 (10%) 1 (10%)
Skin, Site of Application, Inflammation,
Chronic 1 (10%) 1 (10%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 17:45:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Foreign Body 1 (10%)
Infiltration Cellular, Histiocyte 2 (20%) 4 (40%) 3 (30%)
Inflammation, Chronic Active 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
Nose (10) (10) (10) (10)
Fungus 1 (10%)
Inflammation, Acute 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Lens, Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Nephropathy, Chronic 9 (90%) 10 (100%) 10 (100%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 17:45:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (10) (10) (10) (10)
Erosion 1 (10%) 1 (10%)
Inflammation, Chronic Active 1 (10%)
Ulcer 1 (10%)
Liver (10) (10) (10) (10)
Basophilic Focus 4 (40%)
Clear Cell Focus 3 (30%) 2 (20%)
Eosinophilic Focus 1 (10%)
Fatty Change, Focal 10 (100%) 9 (90%) 8 (80%) 10 (100%)
Hepatodiaphragmatic Nodule 2 (20%) 1 (10%)
Necrosis 1 (10%)
Mesentery (1) (1)
Fat, Inflammation, Chronic Active 1 (100%)
Fat, Necrosis 1 (100%)
Pancreas (10) (10) (10) (10)
Pigmentation 1 (10%)
Acinus, Atrophy 3 (30%) 5 (50%) 6 (60%) 7 (70%)
Salivary Glands (10) (10) (10) (10)
Duct, Metaplasia, Squamous 2 (20%) 3 (30%) 2 (20%) 4 (40%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10)
Cardiomyopathy 10 (100%) 10 (100%) 9 (90%) 10 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hyperplasia 1 (10%)
Adrenal Medulla (10) (10) (10) (10)
Hyperplasia 1 (10%) 2 (20%)
Islets, Pancreatic (10) (10) (10) (10)
Hyperplasia 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 17:45:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pituitary Gland (9) (10) (10) (9)
Pars Distalis, Angiectasis 3 (33%) 2 (20%) 2 (22%)
Pars Distalis, Cyst 1 (11%) 1 (10%) 3 (30%)
Pars Distalis, Hyperplasia 6 (67%) 2 (20%) 2 (20%) 2 (22%)
Pars Intermedia, Cyst 2 (20%) 1 (11%)
Thyroid Gland (10) (10) (10) (10)
C-Cell, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (10) (10) (10) (10)
Interstitial Cell, Hyperplasia 9 (90%) 5 (50%) 4 (40%) 8 (80%)
Seminiferous Tubule, Atrophy 2 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Pancreatic, Hyperplasia 1 (100%)
Lymph Node, Mesenteric (10) (10) (10) (10)
Ectasia 1 (10%) 1 (10%)
Spleen (10) (10) (10) (10)
Fibrosis 1 (10%) 1 (10%)
Capsule, Pigmentation 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Inflammation, Chronic 1 (10%) 1 (10%)
Skin, Site of Application, Acanthosis 1 (10%) 10 (100%) 9 (90%) 9 (90%)
Skin, Site of Application, Inflammation,
Chronic 2 (20%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 17:45:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (9) (10)
Edema 1 (10%)
Hemorrhage 1 (10%) 4 (40%) 1 (10%)
Infiltration Cellular, Histiocyte 2 (20%) 3 (30%) 1 (11%)
Nose (10) (9) (10) (10)
Fungus 2 (20%) 1 (10%)
Inflammation, Chronic Active 4 (40%) 3 (33%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Cyst 1 (10%) 1 (10%)
Nephropathy, Chronic 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Urinary Bladder (10) (10) (10) (10)
Calculus Gross Observation 1 (10%) 1 (10%) 2 (20%)
Calculus Micro Observation Only 1 (10%) 1 (10%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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