TDMS Study 05069-08 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE NTP Experiment-Test: 05069-08 Report: PEIRPT05 Study Type: CHRONIC Date: 03/13/95 Route: DERMAL,SOLUTION Time: 18:03:28 66 WEEK SSAC Facility: TSI Mason Research Chemical CAS #: 147-47-7 Lock Date: 08/21/92 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95 Route: DERMAL,SOLUTION Time: 18:03:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 60 60 60 60 Scheduled Sacrifice 10 10 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Stomach, Forestomach (10) (10) (10) (10) Squamous Cell Papilloma 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Pituitary Gland (10) (10) (10) (10) Pars Distalis, Adenoma 4 (40%) 3 (30%) 4 (40%) 5 (50%) Pars Distalis, Adenoma, Multiple 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (10) (10) (10) (10) Adenoma 1 (10%) Uterus (10) (10) (10) (10) Polyp Stromal 1 (10%) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95 Route: DERMAL,SOLUTION Time: 18:03:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Thymus (10) (9) (10) (10) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (10) (10) (10) (10) Fibroadenoma 1 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(10) *(10) *(10) *(10) Lymphoma Malignant 1 (10%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 3 NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95 Route: DERMAL,SOLUTION Time: 18:03:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 6 4 5 6 Total Primary Neoplasms 6 5 5 6 Total Animals with Benign Neoplasms 6 4 4 6 Total Benign Neoplasms 6 5 4 6 Total Animals with Malignant Neoplasms 1 Total Malignant Neoplasms 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 4 NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95 Route: DERMAL,SOLUTION Time: 18:03:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 60 60 60 60 Scheduled Sacrifice 10 10 10 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Pancreas (10) (10) (10) (10) Acinus, Adenoma 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Medulla (10) (10) (10) (10) Pheochromocytoma Benign 1 (10%) Islets, Pancreatic (10) (10) (10) (10) Carcinoma 1 (10%) Pituitary Gland (9) (10) (10) (9) Pars Distalis, Adenoma 5 (56%) 4 (40%) 1 (11%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (10) (10) (10) (10) Testes (10) (10) (10) (10) Bilateral, Interstitial Cell, Adenoma 5 (50%) 4 (40%) 2 (20%) Interstitial Cell, Adenoma 5 (50%) 3 (30%) 3 (30%) 5 (50%) ____________________________________________________________________________________________________________________________________ Page 5 NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95 Route: DERMAL,SOLUTION Time: 18:03:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (10) (10) (10) (10) Lymph Node, Mesenteric (10) (10) (10) (10) Spleen (10) (10) (10) (10) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (9) (10) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(10) *(10) *(10) *(10) Leukemia Mononuclear 1 (10%) 2 (20%) Mesothelioma Malignant 1 (10%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 6 NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95 Route: DERMAL,SOLUTION Time: 18:03:28 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100 MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 7 9 9 8 Total Primary Neoplasms 12 10 14 8 Total Animals with Benign Neoplasms 7 8 9 8 Total Benign Neoplasms 11 8 12 8 Total Animals with Malignant Neoplasms 1 2 2 Total Malignant Neoplasms 1 2 2 Total Animals with Metastatic Neoplasms 1 Total Metastatic Neoplasm 1 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------