TDMS Study 05069-08 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-08 Report: PEIRPT05
Study Type: CHRONIC Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:03:28
66 WEEK SSAC
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 08/21/92
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:03:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
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ALIMENTARY SYSTEM
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 1 (10%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Adenoma 4 (40%) 3 (30%) 4 (40%) 5 (50%)
Pars Distalis, Adenoma, Multiple 1 (10%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (10) (10) (10) (10)
Adenoma 1 (10%)
Uterus (10) (10) (10) (10)
Polyp Stromal 1 (10%)
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Page 2
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:03:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Thymus (10) (9) (10) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (10) (10)
Fibroadenoma 1 (10%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Lymphoma Malignant 1 (10%)
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* Number of animals with any tissue examined microscopically
Page 3
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:03:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 6 4 5 6
Total Primary Neoplasms 6 5 5 6
Total Animals with Benign Neoplasms 6 4 4 6
Total Benign Neoplasms 6 5 4 6
Total Animals with Malignant Neoplasms 1
Total Malignant Neoplasms 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 4
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:03:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Pancreas (10) (10) (10) (10)
Acinus, Adenoma 1 (10%)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (10) (10) (10) (10)
Pheochromocytoma Benign 1 (10%)
Islets, Pancreatic (10) (10) (10) (10)
Carcinoma 1 (10%)
Pituitary Gland (9) (10) (10) (9)
Pars Distalis, Adenoma 5 (56%) 4 (40%) 1 (11%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Testes (10) (10) (10) (10)
Bilateral, Interstitial Cell, Adenoma 5 (50%) 4 (40%) 2 (20%)
Interstitial Cell, Adenoma 5 (50%) 3 (30%) 3 (30%) 5 (50%)
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Page 5
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:03:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Lymph Node, Mesenteric (10) (10) (10) (10)
Spleen (10) (10) (10) (10)
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INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (9) (10)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Mononuclear 1 (10%) 2 (20%)
Mesothelioma Malignant 1 (10%)
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* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05069-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 18:03:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 36 MG/KG 60 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 7 9 9 8
Total Primary Neoplasms 12 10 14 8
Total Animals with Benign Neoplasms 7 8 9 8
Total Benign Neoplasms 11 8 12 8
Total Animals with Malignant Neoplasms 1 2 2
Total Malignant Neoplasms 1 2 2
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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