TDMS Study 05069-08 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE
NTP Experiment-Test: 05069-08 Report: PEIRPT09
Study Type: CHRONIC Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
CORE STUDY
Facility: TSI Mason Research
Chemical CAS #: 147-47-7
Lock Date: 08/21/92
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 0| 0| 3| 1| 3| 3| 2| 9| 3| 3| 3| 2| 2| 7| 1| 3| 8| 3| 2| 3| 3| 3| 6| 3| 0|
| 6| 2| 7| 9| 7| 4| 7| 8| 7| 7| 7| 5| 9| 6| 6| 7| 1| 7| 3| 7| 7| 7| 8| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | 2 1|
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X X |
Centrilobular, Necrosis | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 3 3 3 3 3|
Periportal, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2|
Acinus, Atrophy | 2 2 1 1 2 1 1 1 1 1 3|
Artery, Thrombosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 1 2 2 3 |
Inflammation, Chronic | 2 3 2 3 |
Ulcer | 4 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 2 2 3 2 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 2 1 1 2 1 1 1 2 1 2 1 1 2 1 1 1|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 0| 0| 3| 1| 3| 3| 2| 9| 3| 3| 3| 2| 2| 7| 1| 3| 8| 3| 2| 3| 3| 3| 6| 3| 0|
| 6| 2| 7| 9| 7| 4| 7| 8| 7| 7| 7| 5| 9| 6| 6| 7| 1| 7| 3| 7| 7| 7| 8| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | 3 3 |
Valve, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Hematopoietic Cell Proliferation | 1|
Hyperplasia | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 3 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + M + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 3 2 2|
Pars Distalis, Cyst | 3 2 3 3 |
Pars Distalis, Hyperplasia | 1 2 2 3 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
C-Cell, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | 2 1 |
Hyperplasia | 1 |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 4 2 1 3 |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Congestion | |
Pancreatic, Erythrophagocytosis | 2 |
Renal, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 0| 0| 3| 1| 3| 3| 2| 9| 3| 3| 3| 2| 2| 7| 1| 3| 8| 3| 2| 3| 3| 3| 6| 3| 0|
| 6| 2| 7| 9| 7| 4| 7| 8| 7| 7| 7| 5| 9| 6| 6| 7| 1| 7| 3| 7| 7| 7| 8| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 1 2 3 3 1 |
Hematopoietic Cell Proliferation | 3 4|
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Ectopic Parathyroid Gland | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Inflammation, Acute | |
Inflammation, Chronic | 1 1|
Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 2 |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1|
Infiltration Cellular, Histiocyte | 2 2 1 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 0| 0| 3| 1| 3| 3| 2| 9| 3| 3| 3| 2| 2| 7| 1| 3| 8| 3| 2| 3| 3| 3| 6| 3| 0|
| 6| 2| 7| 9| 7| 4| 7| 8| 7| 7| 7| 5| 9| 6| 6| 7| 1| 7| 3| 7| 7| 7| 8| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 2 2 |
Capillary, Thrombosis | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Fungus | |
Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 2 2 2 |
Infarct | 2 |
Nephropathy, Chronic | 2 2 2 2 2 3 2 2 3 2 3 1 2 2 3 2 2 2 2 2 2 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 4| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 6| 7| 3| 4| 3| 3| 5| 3| 7| 3| 0| 3| 6| 2| 9| 0| 9| 2| 9| 3| 2| |
| 4| 6| 1| 7| 3| 2| 7| 6| 7| 7| 4| 7| 9| 5| 4| 7| 3| 2| 6| 4| 1| 7| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 4| 5| 7| 8| 0| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 | 3 1.3|
Basophilic Focus | X X X X X X X X X X X X X X X X X | 35 |
Clear Cell Focus | X X X | 7 |
Eosinophilic Focus | X X X X X | 12 |
Hematopoietic Cell Proliferation | 1 | 3 1.3|
Hepatodiaphragmatic Nodule | X X X X X X | 11 |
Inflammation, Granulomatous | 2 | 1 2.0|
Mixed Cell Focus | X X X X X X X | 10 |
Centrilobular, Necrosis | | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 3 3 2 3 3| 11 2.9|
Periportal, Vacuolization Cytoplasmic| 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis | 2 2 3 2 | 6 2.2|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Acinus, Atrophy | 2 1 1 1 1 2 1 1 | 19 1.4|
Artery, Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 2 2 2 2 4 2 3 | 13 2.2|
Inflammation, Chronic | 2 3 3 2 3 | 9 2.6|
Ulcer | 1 2 2 3 1 4 3 | 10 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 1 2 2 3 2| 13 2.2|
Mineralization | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 4| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 6| 7| 3| 4| 3| 3| 5| 3| 7| 3| 0| 3| 6| 2| 9| 0| 9| 2| 9| 3| 2| |
| 4| 6| 1| 7| 3| 2| 7| 6| 7| 7| 4| 7| 9| 5| 4| 7| 3| 2| 6| 4| 1| 7| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 4| 5| 7| 8| 0| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 1 2 1 2 1 1 1 2 1 1 1 3 2 2 2 2 | 41 1.4|
Mineralization | 1 | 1 1.0|
Atrium, Thrombosis | 4| 3 3.3|
Valve, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 2 1 1 1 1 1 | 7 1.3|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 1 1 1 2 2 2 1 | 13 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + + + + + + + + M + + + + + + + +| 44 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 2 3 3| 9 2.4|
Pars Distalis, Cyst | 2 3 | 6 2.7|
Pars Distalis, Hyperplasia | 1 3 1 2| 11 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 1 2 | 9 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 3 1.7|
Hyperplasia | 3 3 | 3 2.3|
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 2 | 8 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 4| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 6| 7| 3| 4| 3| 3| 5| 3| 7| 3| 0| 3| 6| 2| 9| 0| 9| 2| 9| 3| 2| |
| 4| 6| 1| 7| 3| 2| 7| 6| 7| 7| 4| 7| 9| 5| 4| 7| 3| 2| 6| 4| 1| 7| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 4| 5| 7| 8| 0| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 13 |
Mediastinal, Congestion | 2 | 1 2.0|
Pancreatic, Erythrophagocytosis | | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 3 2.0|
Infiltration Cellular, Plasma Cell | 3 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 4 | 1 4.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Fibrosis | 3 | 6 2.2|
Hematopoietic Cell Proliferation | 2 | 3 3.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + M + + + + + + + + + + + +| 47 |
Ectopic Parathyroid Gland | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + I + + + + + + M + + + + + + + + + +| 48 |
Galactocele | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 2 1.0|
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic | 1 3 1 1 | 6 1.3|
Ulcer | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 2 | 2 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 2.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 4| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 6| 7| 3| 4| 3| 3| 5| 3| 7| 3| 0| 3| 6| 2| 9| 0| 9| 2| 9| 3| 2| |
| 4| 6| 1| 7| 3| 2| 7| 6| 7| 7| 4| 7| 9| 5| 4| 7| 3| 2| 6| 4| 1| 7| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| L |
| 4| 5| 7| 8| 0| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Chronic | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 4 1 | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 2 | 5 1.6|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | | 3 1.7|
Capillary, Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Fungus | 1 2| 2 1.5|
Inflammation, Chronic Active | 1 1 2| 4 1.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 4 2.0|
Infarct | | 1 2.0|
Nephropathy, Chronic | 1 2 2 1 2 1 3 1 2 2 2 3 3 1 1 1 4 4 3 2 1 2 3 1| 49 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 4| 7| 4| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 4| 2| 8| 6| 3| 1| 9| 8| 3| 8| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 7| 9| 2| 7| 7| 5| 4| 2| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
36 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + A + + +|
Erosion | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Erosion | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + A + + + + + + + + + + A + + +|
Hemorrhage | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + A + + + A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + A + + + A + + + + + + + + + + A + + +|
Inflammation, Chronic | |
Metaplasia, Osseous | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X X X X|
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X X X |
Regeneration | 3 |
Centrilobular, Atrophy | |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 2 |
Periportal, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 1 1 2 1 1 1 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 3 3 1 |
Inflammation, Chronic | 3 3 |
Ulcer | 4 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 4| 7| 4| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 4| 2| 8| 6| 3| 1| 9| 8| 3| 8| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 7| 9| 2| 7| 7| 5| 4| 2| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
36 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 1 1 2 2 2 1 2 1 1 2 2 2 2 2 1 2 2 1 2 1|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 1 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Pars | |
Intermedia, Hyperplasia | 2 |
Pars Distalis, Angiectasis | 2 2 2 3 3 3 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | 4 1 |
Hyperplasia | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + |
Bronchial, Depletion Lymphoid | |
Lumbar, Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 4| 7| 4| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 4| 2| 8| 6| 3| 1| 9| 8| 3| 8| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 7| 9| 2| 7| 7| 5| 4| 2| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
36 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Ectasia | |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Ectasia | |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X X |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Inflammation, Chronic | 1 1 1 1 1 1 1|
Skin, Site of Application, Acanthosis| |
Skin, Site of Application, | |
Hyperkeratosis | |
Skin, Site of Application, | |
Inflammation, Chronic | 1 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 1 |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fracture | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 6| 4| 7| 4| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 4| 2| 8| 6| 3| 1| 9| 8| 3| 8| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3|
| 7| 9| 2| 7| 7| 5| 4| 2| 5| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
36 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
| 6| 7| 8| 9| 0| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 1 1 2 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Edema | |
Serosa, Fibrosis | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Fungus | 2 |
Inflammation, Chronic Active | 2 2 2 |
Thrombosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy, Chronic | 3 1 3 3 1 2 2 3 1 3 3 1 2 3 2 3 2 3 3 2 3 3 3|
Pigmentation | 2 |
Papilla, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7| |
DAY ON TEST | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2| |
| 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
36 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
| 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 47 |
Erosion | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + A +| 47 |
Erosion | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + A + + + A + + + + + + + + + A +| 43 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + A + + + + + + + + + A +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + A + A A + + + + + + A +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + A + + + A + + A A + + + + + A +| 40 |
Inflammation, Chronic | 3 | 1 3.0|
Metaplasia, Osseous | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 36 |
Clear Cell Focus | X X X | 7 |
Eosinophilic Focus | X X X X X X X| 16 |
Hepatodiaphragmatic Nodule | X X | 5 |
Mixed Cell Focus | X X X | 6 |
Regeneration | | 1 3.0|
Centrilobular, Atrophy | 2 | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 3 3 3 | 5 2.8|
Periportal, Vacuolization Cytoplasmic| 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | 2 2 3 2 | 7 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 1 1 | 15 1.1|
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 2 3 2 2 3| 10 2.4|
Inflammation, Chronic | 2 2 2 3| 6 2.5|
Ulcer | 4 1 3 1 4 | 8 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7| |
DAY ON TEST | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2| |
| 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
36 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
| 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 1 1 1 1 | 6 1.3|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 2 2 2 1 1 2 1 1 2 1 2 2 2 1 2 2 1 1| 46 1.6|
Atrium, Thrombosis | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia | 4 4 | 4 2.8|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 1 2 1 2 1 2 1| 12 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Craniopharyngeal Duct, Pars | | |
Intermedia, Hyperplasia | | 1 2.0|
Pars Distalis, Angiectasis | 2 3 2 2 3 2 3 | 13 2.5|
Pars Distalis, Cyst | 3 | 2 2.5|
Pars Distalis, Hyperplasia | 2 2 2 2 2 1 2 2 | 13 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 1| 12 1.1|
Follicular Cell, Hyperplasia | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + + M + + + + + + + +| 46 |
Cyst | | 2 2.5|
Hyperplasia | | 1 2.0|
Inflammation, Acute | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7| |
DAY ON TEST | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2| |
| 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
36 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
| 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 10 |
Bronchial, Depletion Lymphoid | 3 | 1 3.0|
Lumbar, Depletion Lymphoid | 3 | 1 3.0|
Mediastinal, Ectasia | | 1 2.0|
Mediastinal, Hemorrhage | 2 2 4 | 3 2.7|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Pancreatic, Ectasia | 2 | 1 2.0|
Pancreatic, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 4 | 1 4.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 | 4 2.3|
Hematopoietic Cell Proliferation | 3 3 2 3 | 5 2.8|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | X X X X X X | 10 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 1.0|
Inflammation, Chronic | 1 1 1 | 10 1.0|
Skin, Site of Application, Acanthosis| 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7| |
DAY ON TEST | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2| |
| 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
36 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
| 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin, Site of Application, | | |
Hyperkeratosis | 1 | 1 1.0|
Skin, Site of Application, | | |
Inflammation, Chronic | | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 2 | 3 1.7|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fracture | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 | 5 1.2|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Edema | 2 | 1 2.0|
Serosa, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X| 2 |
Fungus | 2 2| 3 2.0|
Inflammation, Chronic Active | 2 2 2| 6 2.0|
Thrombosis | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 4| 5| 7| 5| 6| 7| 7| 6| 7| 7| 6| 2| 7| |
DAY ON TEST | 0| 3| 3| 8| 1| 5| 1| 3| 3| 1| 3| 8| 9| 2| 3| 0| 4| 3| 3| 7| 3| 3| 7| 9| 2| |
| 8| 8| 7| 8| 4| 4| 9| 7| 7| 3| 6| 8| 2| 4| 6| 5| 7| 4| 6| 2| 6| 6| 3| 2| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
36 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| L |
| 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 3 2 2 4 1 4 3 2 3 3 3 2 1 3 1 1 2 2 3 3 3 3| 45 2.4|
Pigmentation | 2 | 2 2.0|
Papilla, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + A +| 48 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 4| 6| 6| 7| 4| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 6| 3| 9| 3| 3| 4| 0| 9| 3| 5| 0| 6| 3| 1| 3| 3| 2| 3| 1| 3|
| 6| 6| 0| 6| 6| 4| 6| 7| 6| 6| 7| 2| 1| 6| 7| 9| 3| 6| 9| 6| 6| 6| 6| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
60 MG/KG | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0|
| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + A + + + A + + A A + + + + + + + + +|
Edema | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + A + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + A + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + A + + A A A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Congestion | |
Eosinophilic Focus | X X X X X X X X X X |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X X X X X |
Regeneration | |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 2 3|
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 1 |
Metaplasia, Osseous | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 1 2 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Hyperplasia, Squamous | 2 2 3|
Inflammation, Chronic | 2 2 3|
Ulcer | 3 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 2 1 2 1 2 1 2 1 1 1 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 4| 6| 6| 7| 4| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 6| 3| 9| 3| 3| 4| 0| 9| 3| 5| 0| 6| 3| 1| 3| 3| 2| 3| 1| 3|
| 6| 6| 0| 6| 6| 4| 6| 7| 6| 6| 7| 2| 1| 6| 7| 9| 3| 6| 9| 6| 6| 6| 6| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
60 MG/KG | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0|
| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Metaplasia, Hepatocyte | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 3 3 |
Pars Distalis, Hyperplasia | 3 2 1 2 1 3 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + M + M + M + + + + + + + + + +|
Cyst | |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + +|
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 4| 6| 6| 7| 4| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 6| 3| 9| 3| 3| 4| 0| 9| 3| 5| 0| 6| 3| 1| 3| 3| 2| 3| 1| 3|
| 6| 6| 0| 6| 6| 4| 6| 7| 6| 6| 7| 2| 1| 6| 7| 9| 3| 6| 9| 6| 6| 6| 6| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
60 MG/KG | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0|
| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Inflammation, Chronic | 1 1 1 1 1 |
Necrosis | |
Skin, Site of Application, Acanthosis| 1 1 |
Skin, Site of Application, | |
Hyperkeratosis | 1 1 |
Skin, Site of Application, | |
Inflammation, Chronic | |
Subcutaneous Tissue, Foreign Body | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Skin, Site of | |
Application, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
Axon, Degeneration | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 3 |
Inflammation, Chronic Active | 2 |
Thrombosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 4| 6| 6| 7| 4| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 6| 3| 9| 3| 3| 4| 0| 9| 3| 5| 0| 6| 3| 1| 3| 3| 2| 3| 1| 3|
| 6| 6| 0| 6| 6| 4| 6| 7| 6| 6| 7| 2| 1| 6| 7| 9| 3| 6| 9| 6| 6| 6| 6| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
60 MG/KG | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0|
| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Iris, Synechia | 4 |
Lens, Cataract | 4 3 |
Retina, Atrophy | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Nephropathy, Chronic | 2 2 1 2 3 2 2 2 2 3 2 3 2 1 2 2 1 1 3 3 2 1 3 2|
Pigmentation | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 6| 3| 3| 0| 5| 8| 3| 3| 2| 3| 9| 3| 9| 9| 9| 3| 8| 5| 0| 3| |
| 0| 0| 6| 6| 0| 8| 6| 6| 9| 1| 8| 6| 6| 7| 6| 4| 6| 2| 8| 2| 6| 9| 9| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
60 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + A + A +| 42 |
Edema | 2 | 1 2.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + A + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + A + + A + + +| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X| 32 |
Clear Cell Focus | X X X X | 9 |
Congestion | 2 | 1 2.0|
Eosinophilic Focus | X X X X X X X | 17 |
Hepatodiaphragmatic Nodule | X X X | 6 |
Mixed Cell Focus | X X X X | 9 |
Regeneration | 4 3 | 2 3.5|
Centrilobular, Vacuolization | | |
Cytoplasmic | 3 3 2 | 6 2.7|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Inflammation, Chronic | | 1 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
Fat, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
Acinus, Atrophy | 2 1 1 1 1 1 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Diverticulum | | 1 |
Hyperplasia, Squamous | 2 3 2 | 6 2.3|
Inflammation, Chronic | 3 2 | 5 2.4|
Ulcer | 3 2 1 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 1 3 1 1 | 6 1.7|
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 6| 3| 3| 0| 5| 8| 3| 3| 2| 3| 9| 3| 9| 9| 9| 3| 8| 5| 0| 3| |
| 0| 0| 6| 6| 0| 8| 6| 6| 9| 1| 8| 6| 6| 7| 6| 4| 6| 2| 8| 2| 6| 9| 9| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
60 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 1 2 2 2 2 2 1 1 1 1 1 1 2 2 2 1 2 1 2 1 1 1 1| 43 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
Vacuolization Cytoplasmic | 2 1 1 1 1 2 | 8 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Metaplasia, Hepatocyte | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 4 2 2 3 | 7 2.6|
Pars Distalis, Hyperplasia | 3 2 4 2 2 3| 16 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 1 1 1 1| 11 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 45 |
Cyst | 3 | 1 3.0|
Inflammation, Acute | 1 2 | 2 1.5|
Inflammation, Chronic | 1| 2 1.5|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 | 5 3.2|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | + | 2 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 7 |
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 6| 3| 3| 0| 5| 8| 3| 3| 2| 3| 9| 3| 9| 9| 9| 3| 8| 5| 0| 3| |
| 0| 0| 6| 6| 0| 8| 6| 6| 9| 1| 8| 6| 6| 7| 6| 4| 6| 2| 8| 2| 6| 9| 9| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
60 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 | 3 2.3|
Hematopoietic Cell Proliferation | 3 2 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Galactocele | X X| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 3 1 | 5 1.4|
Inflammation, Chronic | 1 1 1| 8 1.0|
Necrosis | 4 | 1 4.0|
Skin, Site of Application, Acanthosis| 1 1 1 1 1 1 1 | 9 1.0|
Skin, Site of Application, | | |
Hyperkeratosis | 1 1 1 1 1 | 7 1.0|
Skin, Site of Application, | | |
Inflammation, Chronic | 1 1 | 2 1.0|
Subcutaneous Tissue, Foreign Body | X | 1 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 2 1| 3 1.7|
Subcutaneous Tissue, Skin, Site of | | |
Application, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 1.5|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Axon, Degeneration | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 6| 3| 3| 0| 5| 8| 3| 3| 2| 3| 9| 3| 9| 9| 9| 3| 8| 5| 0| 3| |
| 0| 0| 6| 6| 0| 8| 6| 6| 9| 1| 8| 6| 6| 7| 6| 4| 6| 2| 8| 2| 6| 9| 9| 7| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
60 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| L |
| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Edema | | 1 2.0|
Infiltration Cellular, Histiocyte | 1| 2 1.5|
Inflammation, Chronic Active | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X| 2 |
Fungus | 2 | 2 2.5|
Inflammation, Chronic Active | 2 2| 3 2.0|
Thrombosis | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Iris, Synechia | | 1 4.0|
Lens, Cataract | | 2 3.5|
Retina, Atrophy | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
Nephropathy, Chronic | 3 2 3 2 3 2 3 2 1 1 1 2 1 3 3 3 2 3 1 2 1 2 2 3| 48 2.1|
Pigmentation | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 5| 6| 6| 7|
DAY ON TEST | 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 8| 3| 5| 2| 8| 4| 8| 3|
| 9| 6| 6| 5| 6| 8| 6| 6| 6| 2| 8| 6| 6| 6| 6| 6| 6| 4| 6| 5| 2| 3| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X X X X X X X|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X X X X X |
Inflammation, Chronic | 1 1 |
Mixed Cell Focus | X X X X X X |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 2 3 3 |
Midzonal, Vacuolization Cytoplasmic | 2 |
Serosa, Inflammation, Acute | |
Serosa, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Hepatocyte | |
Acinus, Atrophy | 1 1 1 1 1 1 1 1 1 |
Acinus, Hyperplasia | |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 3 |
Inflammation, Chronic | 2 3 |
Perforation | |
Ulcer | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 3 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 1 3 2 2 2 1 2 3 1 1 1 1 2 1 1 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 5| 6| 6| 7|
DAY ON TEST | 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 8| 3| 5| 2| 8| 4| 8| 3|
| 9| 6| 6| 5| 6| 8| 6| 6| 6| 2| 8| 6| 6| 6| 6| 6| 6| 4| 6| 5| 2| 3| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration | |
Hyperplasia | 1 1 |
Necrosis | |
Vacuolization Cytoplasmic | 1 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Hepatocyte | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 4 3 3 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 3 2 2 2 |
Rathke's Cleft, Cyst | 2 |
Rathke's Cleft, Hemorrhage | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Bilateral, Cyst | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Cystic | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 5| 6| 6| 7|
DAY ON TEST | 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 8| 3| 5| 2| 8| 4| 8| 3|
| 9| 6| 6| 5| 6| 8| 6| 6| 6| 2| 8| 6| 6| 6| 6| 6| 6| 4| 6| 5| 2| 3| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 |
Capsule, Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Ectopic Parathyroid Gland | 1 |
Metaplasia, Osseous | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Inflammation, Chronic | 1 1 |
Necrosis, Chronic | |
Skin, Site of Application, Acanthosis| 1 1 1 1 1 1 1 1 1 1 |
Skin, Site of Application, | |
Hyperkeratosis | |
Skin, Site of Application, | |
Inflammation, Chronic | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic | 2 2 |
Inflammation, Granulomatous | 2 |
Alveolar Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X |
Fungus | 2 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 7| 5| 6| 6| 7|
DAY ON TEST | 7| 3| 3| 7| 3| 0| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 3| 8| 3| 5| 2| 8| 4| 8| 3|
| 9| 6| 6| 5| 6| 8| 6| 6| 6| 2| 8| 6| 6| 6| 6| 6| 6| 4| 6| 5| 2| 3| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
Posterior Chamber, Hemorrhage | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 3 1 3 3 2 1 2 3 3 2 3 2 1 2 2 4 1 4 1 2 2 4 4 2|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 7| 7| 3| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 4| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 4| 8| 9| 3| 0| 0| 3| 3| 8| 3| 3| 2| 4| 3| 3| 2| 4| 3| 4| 3| 1| 1| 0| 1| |
| 6| 1| 8| 8| 6| 2| 4| 6| 6| 1| 6| 6| 7| 4| 6| 6| 6| 0| 6| 8| 6| 0| 4| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
100 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| L |
MG/KG | 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + A + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + A + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + A + + + + + + + + A + + +| 45 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + A + + + A + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A A + + + + + + A + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + A A + + A + + + A + + + + A + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.0|
Basophilic Focus | X X X X X X X X X X | 30 |
Clear Cell Focus | X X X X X | 12 |
Eosinophilic Focus | X X X X X X X | 14 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X X X | 16 |
Inflammation, Chronic | 1 | 3 1.0|
Mixed Cell Focus | X X X X X | 11 |
Centrilobular, Vacuolization | | |
Cytoplasmic | 2 4 1 3 2| 9 2.4|
Midzonal, Vacuolization Cytoplasmic | | 1 2.0|
Serosa, Inflammation, Acute | 2| 1 2.0|
Serosa, Necrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + +| 3 |
Fat, Necrosis | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Hepatocyte | 1 | 1 1.0|
Acinus, Atrophy | 2 1 1 2 2| 14 1.2|
Acinus, Hyperplasia | 1| 1 1.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 2 2 3| 7 2.4|
Inflammation, Chronic | 2 2 2| 5 2.2|
Perforation | X| 1 |
Ulcer | 2 4 4| 5 3.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Erosion | 1 3 2 1| 7 1.9|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 7| 7| 3| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 4| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 4| 8| 9| 3| 0| 0| 3| 3| 8| 3| 3| 2| 4| 3| 3| 2| 4| 3| 4| 3| 1| 1| 0| 1| |
| 6| 1| 8| 8| 6| 2| 4| 6| 6| 1| 6| 6| 7| 4| 6| 6| 6| 0| 6| 8| 6| 0| 4| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
100 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| L |
MG/KG | 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 2 1 1 1 2 2 2 1 1 1 2 2 2 1 2 2 2 1| 43 1.5|
Atrium, Thrombosis | 4 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Degeneration | 3 | 1 3.0|
Hyperplasia | 1 1 1 | 5 1.0|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 2 2 2 | 8 1.9|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Hepatocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 4 2 2 2 1 | 11 2.5|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 3 2 2 3 2 | 11 2.3|
Rathke's Cleft, Cyst | | 1 2.0|
Rathke's Cleft, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
C-Cell, Hyperplasia | 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Cyst | 3 3 | 2 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 3 3 4 | 7 2.9|
Bilateral, Cyst | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 7| 7| 3| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 4| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 4| 8| 9| 3| 0| 0| 3| 3| 8| 3| 3| 2| 4| 3| 3| 2| 4| 3| 4| 3| 1| 1| 0| 1| |
| 6| 1| 8| 8| 6| 2| 4| 6| 6| 1| 6| 6| 7| 4| 6| 6| 6| 0| 6| 8| 6| 0| 4| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
100 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| L |
MG/KG | 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
Hyperplasia, Cystic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 4 2.3|
Capsule, Necrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2| 1 2.0|
Ectopic Parathyroid Gland | | 1 1.0|
Metaplasia, Osseous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | X X X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 | 3 1.0|
Inflammation, Chronic | 1 1 1 1 2 1 | 8 1.1|
Necrosis, Chronic | 1 | 1 1.0|
Skin, Site of Application, Acanthosis| 1 1 1 1 1 1 1 1 1 1 1 1| 22 1.0|
Skin, Site of Application, | | |
Hyperkeratosis | 1 | 1 1.0|
Skin, Site of Application, | | |
Inflammation, Chronic | 1 1 | 2 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 7| 6| 7| 7| 3| 5| 7| 7| 6| 6| 7| 7| 6| 5| 7| 4| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 4| 8| 9| 3| 0| 0| 3| 3| 8| 3| 3| 2| 4| 3| 3| 2| 4| 3| 4| 3| 1| 1| 0| 1| |
| 6| 1| 8| 8| 6| 2| 4| 6| 6| 1| 6| 6| 7| 4| 6| 6| 6| 0| 6| 8| 6| 0| 4| 1| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
100 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| L |
MG/KG | 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 | 3 1.0|
Inflammation, Chronic | 1 | 3 1.7|
Inflammation, Granulomatous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X | 4 |
Fungus | | 2 1.5|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Chronic Active | 1 2 | 7 1.7|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Lens, Cataract | 4 2 | 3 2.7|
Posterior Chamber, Hemorrhage | | 1 3.0|
Retina, Degeneration | 4 | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 2 2 1 3 2 3 3 1 2 2 3 2 1 3 3 1 1 2 1 2 1 1 4| 49 2.2|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|
| 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + A + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + A + + + + + + + + + + + A + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A A + + + A + + + + + + + + + + + A + A +|
Dilatation | |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A + + + A + + + + + + A + + + + A + A +|
Diverticulum | X |
Inflammation, Chronic | 3 |
Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1|
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X X X |
Congestion | 2 |
Degeneration, Cystic | 2 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic | 1 |
Necrosis | 2 2 1 |
Centrilobular, Necrosis | 2 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 3 2 4 3 |
Periportal, Vacuolization Cytoplasmic| 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemorrhage | 3 3 |
Inflammation, Granulomatous | 3 |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
Acinus, Atrophy | 1 1 2 2 2 1 2 4 2 2 1 1 1 |
Acinus, Hyperplasia | 1 |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 3 1 3 3 3 4 2 4 2 3 2 2|
Inflammation, Chronic | 3 2 3 2 2 4 4 2 4 |
Inflammation, Chronic Active | 4 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|
| 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Perforation | X X X |
Ulcer | 2 4 4 4 2 3 4 4 4 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 2 2 1 2 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 2 2 3 |
Metaplasia, Squamous | 2 |
Mineralization | 1 4 2 3 4 2 3 3|
Ulcer | 2 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 3 1 1 2 2 3 2 1 3 1 2 3 2 2 1 2 2 1 2 2|
Mineralization | 2 3 2 2 1 1|
Atrium, Inflammation, Acute | 3 |
Atrium, Thrombosis | X 2 X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 1 2 4 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 2 2 2 2 3 4 |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 1 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 3 2 3 3 |
Pars Distalis, Pigmentation | 2 |
Pars Intermedia, Cyst | |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|
| 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
Foreign Body | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Acute | 1 3 |
Inflammation, Chronic | 2 1 2 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 2 3 3 1 3 4 3 3 1|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Interstitial Cell, Hyperplasia | 1 2 1 2 1 1 2 2 2 1 2 2 2 1 1 |
Seminiferous Tubule, Degeneration | 4 4 4 3 2 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 4 3 |
Myelofibrosis | 2 3 3 2 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Angiectasis | 1 3 |
Mediastinal, Congestion | 2 |
Mediastinal, Ectasia | 2 |
Mediastinal, Erythrophagocytosis | |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Angiectasis | 3 |
Pancreatic, Congestion | |
Pancreatic, Hemorrhage | |
Pancreatic, Necrosis | 2 |
Renal, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|
| 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Plasma Cell | 3 3 |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 |
Congestion | 3 |
Depletion Lymphoid | |
Ectasia | 3 3 2 |
Erythrophagocytosis | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 3 2 3 4 3 |
Hematopoietic Cell Proliferation | |
Pigmentation | 2 |
Red Pulp, Thrombosis | X |
__________________________________________________________________________|
Thymus | + + + + M + + + + M M + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + M + + + + + + M + + + + + + + + +|
Galactocele | X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Inflammation, Acute | 1 |
Ulcer | 1 |
Skin, Site of Application, Acanthosis| 1 |
Skin, Site of Application, | |
Hyperkeratosis | 1 1 |
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Skin, Site of | |
Application, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 3 3 3 2 2 2 2 3 3 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 6| 6| 6| 5| 6| 6| 6| 5| 6| 6| 5| 6| 6| 7| 5| 6| 5| 4| 6| 6|
DAY ON TEST | 0| 2| 2| 2| 3| 1| 1| 5| 5| 5| 5| 6| 6| 7| 1| 2| 3| 2| 2| 0| 6| 6| 3| 7| 0|
| 9| 2| 9| 7| 1| 6| 0| 2| 7| 0| 6| 2| 3| 9| 3| 1| 7| 0| 9| 7| 8| 4| 5| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 3 3 1 |
Infiltration Cellular, Histiocyte | 2 2 1 3 2 1 |
Inflammation, Chronic | 1 2 3 |
Inflammation, Chronic Active | |
Mineralization | 4 1 |
Alveolus, Edema | 1 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 1 1 1 1 2|
Fungus | 2 2 2 2 3 2 3 2 2|
Inflammation, Chronic Active | 2 2 2 1 1 2 2 2 2 2 2 2 2 2|
Thrombosis | X |
Ulcer | 3 |
Vein, Thrombosis | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
Hydronephrosis | |
Infarct | |
Mineralization | 3 |
Nephropathy, Chronic | 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 2 3 4 3 4 3 2 4 4|
Renal Tubule, Hyperplasia | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Calculus Gross Observation | |
Hemorrhage | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7| |
DAY ON TEST | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2| |
| 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + A + + + + + + + + + + + + A + + + + +| 42 |
Dilatation | 2 | 1 2.0|
Inflammation, Acute | 4 4 | 2 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + A + + + + + + + + + A + + + + +| 46 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A + + A + + + + + + + + + A + + + + +| 40 |
Diverticulum | | 1 |
Inflammation, Chronic | | 1 3.0|
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 | 6 1.3|
Basophilic Focus | X X | 8 |
Clear Cell Focus | X| 5 |
Congestion | | 1 2.0|
Degeneration, Cystic | 1 | 3 1.3|
Hepatodiaphragmatic Nodule | X X X | 8 |
Inflammation, Chronic | | 1 1.0|
Necrosis | 1 | 4 1.5|
Centrilobular, Necrosis | 2 | 3 2.3|
Centrilobular, Vacuolization | | |
Cytoplasmic | 4 3 2 3 2 3 3 | 12 2.9|
Periportal, Vacuolization Cytoplasmic| 2 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Hemorrhage | | 2 3.0|
Inflammation, Granulomatous | | 1 3.0|
Fat, Necrosis | 2 2 3 | 6 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 | 1 4.0|
Mineralization | 2 | 1 2.0|
Acinus, Atrophy | 1 1 1 1 1 1 2 1 2 2 1 2 | 25 1.5|
Acinus, Hyperplasia | 3| 2 2.0|
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7| |
DAY ON TEST | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2| |
| 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 1 3 2 3 1 4 3 4 1 3 2 2 1 3 2 | 29 2.5|
Inflammation, Chronic | 3 3 3 2 2 2 3 2 | 17 2.7|
Inflammation, Chronic Active | | 1 4.0|
Mineralization | | 1 3.0|
Perforation | X | 4 |
Ulcer | 1 3 4 4 3 4 2 2 2 3 | 20 3.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 2 2 1 1 2 | 13 1.8|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 3 2.3|
Metaplasia, Squamous | | 1 2.0|
Mineralization | 2 2 2 4 1 3 4 | 15 2.7|
Ulcer | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 1 1 1 2 1 1 1 2 2 3 3 2 3 2 3 2 3 1 3 3 3| 47 2.0|
Mineralization | 3 2 2 2 | 10 2.0|
Atrium, Inflammation, Acute | 3 | 2 3.0|
Atrium, Thrombosis | 4 | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 2 2.0|
Hyperplasia | 2 | 2 1.5|
Necrosis | 2 | 2 2.0|
Vacuolization Cytoplasmic | 1 2 2 1 | 9 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 3 1 1 4 1 2 1 1 1 3 1 1 2 3 3 | 28 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 4 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M M + + + + +| 48 |
Hyperplasia | 3 2 3 2 2 3 3 3 2| 18 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 | 4 2.3|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia | 2 2 3 3 1| 11 2.3|
Pars Distalis, Pigmentation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7| |
DAY ON TEST | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2| |
| 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Cyst | X X | 2 |
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Mediastinum, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + + + + | 6 |
Foreign Body | X | 1 |
Inflammation, Acute | 3 | 2 2.5|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Inflammation, Acute | 2 1 2 | 5 1.8|
Inflammation, Chronic | 2 | 4 1.8|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 2 2 3 2 3 2 2 2 3 3 2 2 2| 23 2.4|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 2 1.5|
Interstitial Cell, Hyperplasia | 2 2 1 2 1 1 2 2 1 2 2 1 | 27 1.6|
Seminiferous Tubule, Degeneration | 4 4 4 4 4 4 4 4 4 | 21 3.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypoplasia | 2 2 | 4 2.8|
Myelofibrosis | 3 | 5 2.6|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 19 |
Mediastinal, Angiectasis | | 2 2.0|
Mediastinal, Congestion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7| |
DAY ON TEST | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2| |
| 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Ectasia | | 1 2.0|
Mediastinal, Erythrophagocytosis | 2 2 | 2 2.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Pancreatic, Angiectasis | | 1 3.0|
Pancreatic, Congestion | 1 | 1 1.0|
Pancreatic, Hemorrhage | 2 2 | 2 2.0|
Pancreatic, Necrosis | | 1 2.0|
Renal, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 2 3.0|
Infiltration Cellular, Plasma Cell | 3 4 3 | 5 3.2|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 3.0|
Congestion | | 1 3.0|
Depletion Lymphoid | 4 | 1 4.0|
Ectasia | 2 3 | 5 2.6|
Erythrophagocytosis | 2 2 | 2 2.0|
Hemorrhage | 2 2 | 3 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 3 2 3 | 11 2.9|
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Pigmentation | 2 | 2 2.0|
Red Pulp, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + M + + + + + + + + M M M + + + +| 42 |
Galactocele | X X X X X X X | 12 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 1 1 1 1 1| 9 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7| |
DAY ON TEST | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2| |
| 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute | 1 | 2 1.0|
Ulcer | | 1 1.0|
Skin, Site of Application, Acanthosis| | 1 1.0|
Skin, Site of Application, | | |
Hyperkeratosis | | 2 1.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 1 | 1 1.0|
Subcutaneous Tissue, Skin, Site of | | |
Application, Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 3 2 1 3 2 3 1 2 | 21 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Hemorrhage | 2 1 3 2 | 7 2.1|
Infiltration Cellular, Histiocyte | 2 3 1 2 | 10 1.9|
Inflammation, Chronic | | 3 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | | 2 2.5|
Alveolus, Edema | 2 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 2 1 1 1 1 1 1 1 | 15 1.2|
Fungus | 2 3 2 3 3 3 3 2 2 2 | 19 2.4|
Inflammation, Chronic Active | 2 2 2 2 1 2 2 3 2 3 2 3 | 26 2.0|
Thrombosis | X | 2 |
Ulcer | 3 | 2 3.0|
Vein, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 3| 6| 6| 4| 4| 4| 6| 5| 7| 7| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 7| |
DAY ON TEST | 2| 1| 3| 9| 5| 6| 9| 2| 9| 4| 2| 2| 2| 8| 8| 5| 6| 9| 4| 5| 2| 5| 8| 1| 2| |
| 5| 8| 0| 3| 2| 8| 8| 8| 2| 9| 2| 9| 9| 7| 3| 3| 7| 1| 2| 0| 4| 2| 9| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 5| 6| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 3 |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X | 13 |
Hydronephrosis | 3 | 1 3.0|
Infarct | 2 | 1 2.0|
Mineralization | 1 2 | 3 2.0|
Nephropathy, Chronic | 4 4 4 1 4 4 3 2 2 4 3 4 4 4 4 3 4 4 4 3 4 4 4 3 4| 50 3.6|
Renal Tubule, Hyperplasia | 4 | 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Gross Observation | X X | 2 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|
DAY ON TEST | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|
| 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
36 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Angiectasis | 2 |
Inflammation, Acute | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + A +|
Erosion | 2 |
Inflammation, Acute | 2 2 4 3 |
Necrosis | 4 |
Ulcer | 2 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + + + + + A + + + + + A A + + A A +|
Inflammation, Chronic | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 4 |
Basophilic Focus | X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 2 |
Leukocytosis | |
Mineralization | 1 |
Mixed Cell Focus | |
Regeneration | |
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 3 3 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Inflammation, Acute | 2 |
Inflammation, Granulomatous | |
Acinus, Atrophy | 2 1 1 2 1 2 2 2 1 2 1|
Acinus, Hyperplasia | 1 1 |
Artery, Angiectasis | |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|
DAY ON TEST | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|
| 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
36 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | 3 2 3 3 2 2 2 3 3 3 2 2 2 3 3 2 1 |
Inflammation, Chronic | 2 2 2 2 2 3 2 |
Mineralization | |
Perforation | X X |
Ulcer | 3 2 3 2 4 3 3 2 4 4 1 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 1 1 1 1 1 2 1 |
Inflammation, Chronic | |
Mineralization | 3 4 1 4 2 4 3 4 4 3 3 4 2 3 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 1 3 3 2 1 3 2 2 2 3 3 3 2 3 2 2 2 1 2 3 2|
Mineralization | 2 3 2 3 2 2 2 2 2 4 |
Atrium, Thrombosis | 1 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 |
Hyperplasia | 2 |
Hypertrophy | |
Inflammation, Acute | |
Vacuolization Cytoplasmic | 2 1 2 2 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 1 2 1 1 3 2 1 2 1 2 3 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 3 2 3 3 3 4 4 2 3 2 2|
Mineralization | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Mineralization | 1 |
Craniopharyngeal Duct, Hyperplasia | |
Craniopharyngeal Duct, Pars Nervosa, | |
Hyperplasia | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 1 |
Pars Distalis, Hyperplasia | 3 4 1 2 2 1 3 2|
Pars Nervosa, Cyst | 2 |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|
DAY ON TEST | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|
| 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
36 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Mineralization | 1 |
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Granulomatous | |
Mineralization | |
Necrosis | 3 |
__________________________________________________________________________|
Penis | + + + + + + + |
Inflammation, Acute | 2 4 2 2 |
Mineralization | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 3 2 1 4 3 2 2 1 1 1 1 3 3 1 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Mineralization | 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Interstitial Cell, Hyperplasia | 2 1 2 1 1 1 2 1 1 2 1 2 2 2 1|
Seminiferous Tubule, Degeneration | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Mediastinal, Ectasia | 2 2 |
Mediastinal, Erythrophagocytosis | 2 2 |
Mediastinal, Hemorrhage | 2 2 |
Pancreatic, Angiectasis | 2 |
Pancreatic, Ectasia | 2 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|
DAY ON TEST | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|
| 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
36 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | 3 |
Depletion Lymphoid | |
Ectasia | 3 4 3 |
Erythrophagocytosis | 2 2 |
Hemorrhage | 2 3 2 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 1 2 2 3 2 |
Hematopoietic Cell Proliferation | 2 2 3 3 2 |
Capsule, Necrosis | 2 |
Lymphoid Follicle, Depletion Cellular| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + M + + +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + M + + + + + + + M + + + + + + M + + +|
Galactocele | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Hyperkeratosis | 1 |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Ulcer | |
Skin, Site of Application, Acanthosis| 1 2 1 |
Skin, Site of Application, Cyst | |
Epithelial Inclusion | |
Skin, Site of Application, | |
Hyperkeratosis | 1 1 |
Skin, Site of Application, | |
Inflammation, Chronic | 1 1 1 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 3 2 4 3 3 3 3 3 3 3 4 2 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 5| 6| 6| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 6| 6| 6| 6|
DAY ON TEST | 1| 4| 6| 6| 5| 4| 9| 5| 6| 2| 2| 6| 4| 4| 0| 2| 5| 2| 0| 4| 9| 2| 3| 5| 5|
| 9| 5| 0| 3| 0| 7| 4| 1| 0| 8| 6| 3| 9| 1| 3| 7| 3| 5| 2| 1| 8| 5| 9| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
36 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 4| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 1 2 2 2 3 2 2 2 2 3 |
Inflammation, Acute | 1 |
Mineralization | 1 2 1 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Edema | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X X |
Fungus | 2 2 2 2 2 2 2 |
Hemorrhage | 3 |
Inflammation, Chronic | 4 |
Inflammation, Chronic Active | 2 2 2 2 2 1 1 1 2 |
Ulcer | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Anterior Chamber, Inflammation, Acute| 3 |
Choroid, Mineralization | |
Cornea, Inflammation, Acute | 3 |
Lens, Cataract | 2 |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X |
Mineralization | 3 |
Nephropathy, Chronic | 4 4 4 4 4 4 3 4 4 4 4 3 4 4 3 3 4 4 3 4 4 3 4 4 4|
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6| |
DAY ON TEST | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7| |
| 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
36 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Inflammation, Acute | 1 | 2 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + A + + A A + + + + +| 44 |
Erosion | | 1 2.0|
Inflammation, Acute | 3 2 3 | 7 2.7|
Necrosis | | 1 4.0|
Ulcer | 4 | 3 2.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + A + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + A A + + + + + + + A + + + + + A + + + + +| 37 |
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 3 | 5 2.0|
Basophilic Focus | | 4 |
Clear Cell Focus | X X | 3 |
Degeneration, Cystic | 1 1 2 1 | 6 1.3|
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X X X X | 7 |
Hyperplasia | | 1 2.0|
Leukocytosis | 1 | 1 1.0|
Mineralization | | 1 1.0|
Mixed Cell Focus | X | 1 |
Regeneration | 3 | 1 3.0|
Centrilobular, Necrosis | 2 | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration | 1 | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Acinus, Atrophy | 1 1 2 1 1 2 2 2 1 1 | 21 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6| |
DAY ON TEST | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7| |
| 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
36 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Hyperplasia | 3 | 3 1.7|
Artery, Angiectasis | 4 3| 2 3.5|
Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 1 2 2 2 3 2 1 1 2 2 2 2 2 3 3 3 3| 34 2.3|
Inflammation, Chronic | 2 4 3 2 3 3 2 | 14 2.4|
Mineralization | 2 | 1 2.0|
Perforation | X X X | 5 |
Ulcer | 2 4 4 2 3 4 2 3 4 4 4| 25 3.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 2 1 1 2 1 1 1 1 1 1 1 1| 22 1.2|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | 3 3 3 1 2| 19 2.9|
Ulcer | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 2 2 2 1 2 1 1 3 1 2 2 3 1 1 1 3 2 1 1 1 2| 48 2.0|
Mineralization | 1 2 4 1 1| 15 2.2|
Atrium, Thrombosis | 2 3 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.5|
Hyperplasia | 1| 2 1.5|
Hypertrophy | 2 | 1 2.0|
Inflammation, Acute | 2| 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 1 | 11 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 2 2 2 2 3 1 1 1 2 1 3 1 2| 33 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hyperplasia | 2 3 3 2 2 3 3| 21 2.7|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6| |
DAY ON TEST | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7| |
| 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
36 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Mineralization | | 1 1.0|
Craniopharyngeal Duct, Hyperplasia | 1 | 1 1.0|
Craniopharyngeal Duct, Pars Nervosa, | | |
Hyperplasia | 2 | 1 2.0|
Pars Distalis, Angiectasis | 1 2| 2 1.5|
Pars Distalis, Cyst | 2 2 | 4 1.8|
Pars Distalis, Hyperplasia | 2 1 2 1 1 2 | 14 1.9|
Pars Nervosa, Cyst | | 1 2.0|
Rathke's Cleft, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
C-Cell, Hyperplasia | 1 1 1 1 1 | 7 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Penis | + + + | 10 |
Inflammation, Acute | 2 | 5 2.4|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Acute | | 2 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | 2 2 3 1 2 2 1 3 2 2 2 | 28 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 2 1 2 1 1 1 | 22 1.4|
Seminiferous Tubule, Degeneration | 4 4 4 4 4 4 4 4 4 | 25 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6| |
DAY ON TEST | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7| |
| 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
36 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 15 |
Mediastinal, Ectasia | | 2 2.0|
Mediastinal, Erythrophagocytosis | | 2 2.0|
Mediastinal, Hemorrhage | 3 | 3 2.3|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Ectasia | | 1 2.0|
Pancreatic, Hemorrhage | 1 | 2 1.5|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erythrophagocytosis | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Depletion Lymphoid | 3| 1 3.0|
Ectasia | | 3 3.3|
Erythrophagocytosis | | 2 2.0|
Hemorrhage | 2 | 5 2.2|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 3 3 1 1 | 12 2.2|
Hematopoietic Cell Proliferation | 3 2 | 7 2.4|
Capsule, Necrosis | 2 | 2 2.0|
Lymphoid Follicle, Depletion Cellular| 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M M + + M + + + + + + M + + + + + + +| 44 |
Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + M + + + M + + + + + + +| 42 |
Galactocele | X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 1 1 | 5 1.0|
Hyperkeratosis | | 1 1.0|
Inflammation, Acute | 1 1 | 2 1.0|
Inflammation, Chronic | 1 | 2 1.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6| |
DAY ON TEST | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7| |
| 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
36 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin, Site of Application, Acanthosis| 1 | 4 1.3|
Skin, Site of Application, Cyst | | |
Epithelial Inclusion | X | 1 |
Skin, Site of Application, | | |
Hyperkeratosis | | 2 1.0|
Skin, Site of Application, | | |
Inflammation, Chronic | | 3 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 3 1 3 2 2 2 3| 24 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage | 1 2 1 1 | 9 1.7|
Infiltration Cellular, Histiocyte | 1 2 3 | 13 2.1|
Inflammation, Acute | 2 | 2 1.5|
Mineralization | | 7 1.7|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.0|
Alveolus, Edema | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | X X X X X X | 11 |
Fungus | 2 3 3 2 2 3 2 1 1 2 2 2 1 2 | 21 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 | 24 1.8|
Ulcer | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05069-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2-DIHYDRO-2,2,4-TRIMETHYLQUINOLINE Date: 03/13/95
Route: DERMAL,SOLUTION Time: 19:57:42
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 5| 5| 6| 7| 6| 7| 6| 5| 5| 4| 6| 6| 6| 5| 6| 7| 6| 7| 6| 6| 5| 6| |
DAY ON TEST | 9| 1| 2| 5| 8| 0| 2| 4| 0| 9| 7| 9| 7| 1| 0| 4| 0| 0| 1| 0| 1| 3| 1| 6| 7| |
| 2| 3| 9| 4| 0| 3| 9| 0| 4| 3| 1| 2| 1| 0| 1| 9| 4| 9| 6| 0| 8| 0| 3| 8| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
36 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Anterior Chamber, Inflammation, Acute| | 1 3.0|
Choroid, Mineralization | 2 | 1 2.0|
Cornea, Inflammation, Acute | | 1 3.0|
Lens, Cataract | 2 2 | 3 2.0|
Retina, Degeneration | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X | 10 |
Mineralization | 2 | 2 2.5|
Nephropathy, Chronic | 4 4 4 4 3 4 3 4 4 4 3 4 3 3 4 4 1 2 4 4 4 4 4 3 4| 50 3.7|
Pigmentation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 | 1 1.0|
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked