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https://ntp.niehs.nih.gov/go/3897

TDMS Study 05070-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           VINYL TOLUENE


NTP Experiment-Test: 05070-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43




       Facility:  Midwest Research Institute

       Chemical CAS #:  25013154

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6           10            1                                                  
    Natural Death                                      8            2            7                                                  
    Accidently Killed                                               1            2                                                  
    Dosing Accident                                                              6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           37           34                                                  
  Animals Examined Microscopically                    48           49           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (38)         (2)          (42)                                                
      Dilatation                                       1 (3%)       1 (50%)                                                         
      Infiltration Cellular, Lymphocyte                2 (5%)                    1 (2%)                                             
   Intestine Large, Cecum                             (45)         (2)          (43)                                                
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                    1 (2%)                                             
   Intestine Large, Colon                             (47)         (2)          (46)                                                
      Serosa, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)                                                                       
   Intestine Small                                    (46)         (6)          (47)                                                
      Peyer's Patch, Hyperplasia, Lymphoid             2 (4%)       1 (17%)                                                         
   Intestine Small, Duodenum                          (45)         (3)          (44)                                                
      Serosa, Ileum, Jejunum, Inflammation,                                                                                         
          Chronic Active, Multifocal                   1 (2%)                                                                       
   Liver                                              (48)         (16)         (49)                                                
      Angiectasis, Focal                                            1 (6%)                                                          
      Clear Cell Focus                                                           1 (2%)                                             
      Cytomegaly, Focal                                                          1 (2%)                                             
      Eosinophilic Focus                               1 (2%)                                                                       
      Fatty Change, Diffuse                            1 (2%)                    1 (2%)                                             
      Granuloma, Multifocal                            2 (4%)                                                                       
      Hematocyst                                                    1 (6%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     3 (6%)                    1 (2%)                                             
      Hemorrhage, Multifocal                                                     1 (2%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Diffuse, Lymphocyte       1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte    5 (10%)                   3 (6%)                                             
      Infiltration Cellular, Mixed Cell                1 (2%)                    1 (2%)                                             
      Inflammation, Multifocal, Subacute               8 (17%)                   5 (10%)                                            
      Necrosis, Multifocal                             2 (4%)                    1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal            1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia, Focal                    1 (2%)                                                                       
      Bile Duct, Hyperplasia, Multifocal                            1 (6%)                                                          
      Centrilobular, Necrosis, Diffuse                 1 (2%)       1 (6%)                                                          
      Centrilobular, Necrosis, Multifocal              1 (2%)                                                                       
      Portal, Inflammation, Chronic                                 1 (6%)                                                          
   Mesentery                                          (8)          (3)          (2)                                                 
      Infiltration Cellular, Multifocal, Lymphocyte    2 (25%)                                                                      
      Infiltration Cellular, Mixed Cell                2 (25%)                                                                      
      Fat, Necrosis, Focal                                          1 (33%)                                                         
      Fat, Necrosis, Multifocal                                     2 (67%)                                                         
   Pancreas                                           (47)         (3)          (49)                                                
      Cytomegaly, Multifocal                           2 (4%)                                                                       
      Hypertrophy, Focal                               1 (2%)                                                                       
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    9 (19%)                   4 (8%)                                             
      Infiltration Cellular, Multifocal, Mixed Cell    1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Acinus, Atrophy                                  3 (6%)                    2 (4%)                                             
   Pharynx                                            (1)                                                                           
      Palate, Ulcer, Chronic                           1 (100%)                                                                     
   Salivary Glands                                    (48)         (1)          (48)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte   32 (67%)                  21 (44%)                                            
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
   Stomach, Forestomach                               (47)         (3)          (45)                                                
      Hyperplasia, Diffuse, Squamous                                             1 (2%)                                             
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
   Stomach, Glandular                                 (47)         (3)          (47)                                                
      Developmental Malformation                       1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (2%)                                             
      Inflammation, Chronic Active, Focal                                        1 (2%)                                             
   Tooth                                              (1)                       (1)                                                 
      Developmental Malformation                                                 1 (100%)                                           
      Pulp, Inflammation, Chronic Active, Focal        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (48)         (2)          (48)                                                
      Bacterium                                        1 (2%)                                                                       
      Cardiomyopathy                                                             2 (4%)                                             
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Aortic Valve, Thrombosis                         1 (2%)                                                                       
      Atrium Left, Thrombosis                          1 (2%)                    1 (2%)                                             
      Mitral Valve, Inflammation, Chronic Active,                                                                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
           Focal                                       1 (2%)                                                                       
      Pericardium, Infiltration Cellular,                                                                                           
          Multifocal, Mixed Cell                       1 (2%)                                                                       
      Valve, Pigmentation, Hemosiderin, Multifocal     1 (2%)                                                                       
      Ventricle, Mineralization, Focal                 1 (2%)                                                                       
      Ventricle, Necrosis, Focal, Subacute             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (47)         (3)          (49)                                                
      Adrenal Gland, Accessory Adrenal Cortical                                                                                     
          Nodule                                       2 (4%)                                                                       
      Capsule, Hyperplasia, Diffuse                   13 (28%)      1 (33%)     12 (24%)                                            
      Capsule, Hyperplasia, Multifocal                33 (70%)      1 (33%)     32 (65%)                                            
      Capsule, Inflammation, Chronic Active, Focal     1 (2%)                                                                       
   Adrenal Gland, Cortex                              (47)         (2)          (48)                                                
      Accessory Adrenal Cortical Nodule                4 (9%)                    2 (4%)                                             
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Atrophy, Focal                                                             1 (2%)                                             
      Degeneration, Fatty, Focal                       2 (4%)                                                                       
      Hyperplasia, Focal                               1 (2%)                    2 (4%)                                             
      Hypertrophy, Focal                               1 (2%)                    1 (2%)                                             
      Medulla, Hematopoietic Cell Proliferation,                                                                                    
           Multifocal                                  1 (2%)                                                                       
   Adrenal Gland, Medulla                             (45)         (2)          (47)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)                    1 (2%)                                             
   Islets, Pancreatic                                 (47)         (3)          (49)                                                
      Atrophy, Multifocal                              1 (2%)                    1 (2%)                                             
      Hyperplasia, Multifocal                          7 (15%)      1 (33%)      3 (6%)                                             
   Parathyroid Gland                                  (29)         (1)          (25)                                                
      Infiltration Cellular, Focal, Lymphocyte         1 (3%)                    2 (8%)                                             
   Pituitary Gland                                    (46)         (5)          (47)                                                
      Pars Distalis, Angiectasis, Focal                7 (15%)                                                                      
      Pars Distalis, Hyperplasia, Focal                4 (9%)                                                                       
      Pars Distalis, Hyperplasia, Multifocal           1 (2%)                                                                       
      Pars Distalis, Hypertrophy, Focal                1 (2%)                                                                       
   Thyroid Gland                                      (48)         (2)          (42)                                                
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
      Follicle, Cyst                                   1 (2%)                    2 (5%)                                             
      Follicular Cell, Hyperplasia, Focal              1 (2%)                                                                       
      Follicular Cell, Hyperplasia, Multifocal         2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)                       (1)                                                 
      Cyst, Multifocal                                                           1 (100%)                                           
   Ovary                                              (46)         (14)         (44)                                                
      Abscess, Multiple                                1 (2%)       1 (7%)                                                          
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             9 (20%)      9 (64%)      4 (9%)                                             
      Hemorrhage, Focal                                2 (4%)                                                                       
      Hyperplasia, Diffuse                                                       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                2 (4%)       1 (7%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Periovarian Tissue, Infiltration Cellular,                                                                                    
           Lymphocyte                                  4 (9%)                                                                       
   Uterus                                             (48)         (37)         (45)                                                
      Abscess, Single                                  1 (2%)                                                                       
      Adenomyosis                                      1 (2%)                                                                       
      Angiectasis                                      1 (2%)                                                                       
      Dilatation                                       2 (4%)       5 (14%)     12 (27%)                                            
      Hemorrhage, Acute                                1 (2%)                                                                       
      Hyperplasia, Cystic                             36 (75%)     29 (78%)     29 (64%)                                            
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Metaplasia, Squamous                                                       1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Serosa, Cyst                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (2)          (47)                                                
      Hypoplasia, Focal                                                          1 (2%)                                             
      Myeloid Cell, Hyperplasia                        1 (2%)                                                                       
   Lymph Node                                         (48)         (8)          (49)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Bronchial, Depletion Lymphoid, Diffuse           1 (2%)                                                                       
      Bronchial, Hyperplasia, Lymphoid                                           2 (4%)                                             
      Bronchial, Hyperplasia, Plasma Cell              1 (2%)                    1 (2%)                                             
      Mediastinal, Hemorrhage                          1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                         2 (4%)                                             
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mandibular                             (45)         (1)          (43)                                                
      Hyperplasia, Lymphoid                            4 (9%)                    3 (7%)                                             
      Hyperplasia, Plasma Cell                         3 (7%)                                                                       
      Hyperplasia, Re Cell                             1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Diffuse,                                                                                               
          Polymorphonuclear                            1 (2%)                                                                       
      Pigmentation, Diffuse, Hemosiderin               1 (2%)                    2 (5%)                                             
   Lymph Node, Mesenteric                             (38)         (6)          (32)                                                
      Hematopoietic Cell Proliferation                              2 (33%)                                                         
      Hemorrhage                                       3 (8%)       3 (50%)                                                         
      Hyperplasia, Lymphoid                            4 (11%)                                                                      
      Hyperplasia, Plasma Cell                         1 (3%)                                                                       
      Hyperplasia, Re Cell                             1 (3%)                                                                       
   Spleen                                             (47)         (13)         (49)                                                
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                                                 1 (2%)                                             
      Depletion Lymphoid                                                         2 (4%)                                             
      Developmental Malformation                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 6 (13%)      6 (46%)                                                         
      Hyperplasia, Lymphoid                            6 (13%)                   2 (4%)                                             
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Infarct                                          1 (2%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                        3 (6%)                                                                       
      Capsule, Abscess, Chronic                        1 (2%)                                                                       
      Capsule, Ectopic Tissue                          1 (2%)                                                                       
      Capsule, Fibrosis, Focal                         1 (2%)                                                                       
   Thymus                                             (40)         (2)          (42)                                                
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Cyst, Multiple                                                             1 (2%)                                             
      Depletion Lymphoid                               3 (8%)                    2 (5%)                                             
      Ectopic Parathyroid Gland                        2 (5%)                    2 (5%)                                             
      Hyperplasia, Lymphoid                            1 (3%)                    3 (7%)                                             
      Epithelial Cell, Hyperplasia                     1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (1)          (44)                                                
      Ectasia, Multifocal                              1 (2%)                    1 (2%)                                             
      Hyperplasia, Diffuse                             2 (4%)                                                                       
      Infiltration Cellular, Multifocal, Mixed Cell    1 (2%)                                                                       
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
      Inflammation, Chronic Active, Diffuse            1 (2%)                                                                       
   Skin                                               (46)         (20)         (47)                                                
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
      Inflammation, Chronic Active, Diffuse            1 (2%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Edema                       1 (2%)       1 (5%)                                                          
      Subcutaneous Tissue, Hemorrhage, Acute                        1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (47)         (12)         (47)                                                
      Fibrous Osteodystrophy                           7 (15%)     10 (83%)      8 (17%)                                            
      Joint, Inflammation, Chronic, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (2)          (49)                                                
      Hemorrhage, Acute, Focal                         1 (2%)                                                                       
      Hydrocephalus                                    1 (2%)                                                                       
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Mineralization, Multifocal                      29 (60%)      1 (50%)     16 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (40)         (1)          (40)                                                
      Inflammation, Chronic                            1 (3%)                                                                       
      Inflammation, Chronic Active                     2 (5%)                                                                       
   Lung                                               (48)         (49)         (49)                                                
      Crystals                                                      4 (8%)       1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Infiltration Cellular, Diffuse, Histiocyte       2 (4%)                    2 (4%)                                             
      Infiltration Cellular, Diffuse, Mixed Cell       1 (2%)                                                                       
      Infiltration Cellular, Focal, Histiocyte         1 (2%)       4 (8%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    9 (19%)     10 (20%)      7 (14%)                                            
      Infiltration Cellular, Multifocal, Histiocyte                 6 (12%)      4 (8%)                                             
      Inflammation, Chronic Active, Focal                           1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       1 (2%)       1 (2%)                                             
      Alveolus, Inflammation, Chronic Active, Focal                              1 (2%)                                             
      Alveolus, Inflammation, Chronic Active,                                                                                       
          Multifocal                                                1 (2%)       1 (2%)                                             
      Artery, Inflammation, Acute, Multifocal          1 (2%)                                                                       
      Bronchiole, Hyperplasia, Focal                                1 (2%)                                                          
      Bronchiole, Hyperplasia, Multifocal                           1 (2%)                                                          
      Bronchiole, Inflammation, Chronic Active,                                                                                     
           Focal                                                                 1 (2%)                                             
      Bronchiole, Alveolus, Inflammation, Chronic                                                                                   
          Active, Focal                                             5 (10%)      1 (2%)                                             
      Bronchiole, Alveolus, Inflammation, Chronic                                                                                   
          Active, Multifocal                                        9 (18%)     35 (71%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mediastinum, Infiltration Cellular,                                                                                           
          Multifocal, Lymphocyte                       2 (4%)                                                                       
      Peribronchiolar, Inflammation, Chronic                                                                                        
          Active, Multifocal                           1 (2%)                                                                       
      Pleura, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)                                                                       
   Nose                                               (48)         (49)         (48)                                                
      Exudate                                                       2 (4%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Lumen, Crystals                                                            3 (6%)                                             
      Mucosa, Inflammation, Chronic                    1 (2%)                                                                       
      Mucosa, Inflammation, Chronic Active             3 (6%)      49 (100%)    47 (98%)                                            
      Nasolacrimal Duct, Hyperplasia                                             1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic         3 (6%)                    2 (4%)                                             
      Olfactory Epithelium, Atrophy, Focal             1 (2%)                                                                       
      Respiratory Epithelium, Hyperplasia              5 (10%)     49 (100%)    47 (98%)                                            
   Trachea                                            (48)         (2)          (47)                                                
      Edema                                                                      1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Metaplasia, Multifocal, Squamous                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                                                                           
      Atrophy                                          1 (50%)                                                                      
      Cornea, Neovascularization                       1 (50%)                                                                      
   Lacrimal Gland                                     (10)                      (5)                                                 
      Infiltration Cellular, Focal, Lymphocyte         1 (10%)                   2 (40%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte    6 (60%)                   2 (40%)                                            
      Infiltration Cellular, Multifocal, Mixed Cell    1 (10%)                                                                      
      Infiltration Cellular, Lymphocyte                1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (7)          (49)                                                
      Cyst                                             1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte   22 (46%)                   7 (14%)                                            
      Capsule, Inflammation, Chronic Active            2 (4%)                                                                       
      Cortex, Regeneration, Multifocal                                           2 (4%)                                             
      Cortex, Epithelium, Hyperplasia, Atypical,                                                                                    
           Multifocal                                                            1 (2%)                                             
      Medulla, Epithelium, Karyomegaly, Multifocal     1 (2%)                                                                       
   Urinary Bladder                                    (45)         (2)          (40)                                                
      Infiltration Cellular, Focal, Lymphocyte         2 (4%)                    3 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Infiltration Cellular, Multifocal, Lymphocyte   19 (42%)                   9 (23%)                                            
      Infiltration Cellular, Multifocal, Mixed Cell    1 (2%)                    1 (3%)                                             
      Perforation                                                                1 (3%)                                             
      Serosa, Inflammation, Chronic                    1 (2%)                    2 (5%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           13            4                                                  
    Natural Death                                      6            7            2                                                  
    Accidently Killed                                  1                         1                                                  
    Dosing Accident                                                              2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           30           41                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (9)          (48)                                                
      Inflammation, Chronic Active                     1 (2%)       1 (11%)                                                         
   Gallbladder                                        (41)         (10)         (37)                                                
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Intestine Large, Cecum                             (46)         (7)          (44)                                                
      Hyperplasia, Focal, Lymphoid                                               1 (2%)                                             
      Mucosa, Necrosis, Acute                                                    1 (2%)                                             
   Liver                                              (50)         (23)         (48)                                                
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Anisokaryosis                                    1 (2%)                                                                       
      Basophilic Focus                                 2 (4%)                                                                       
      Basophilic Focus, Multiple                                                 1 (2%)                                             
      Cyst Multilocular                                2 (4%)                    1 (2%)                                             
      Cytomegaly, Focal                                                          1 (2%)                                             
      Degeneration, Ballooning, Multifocal                                       1 (2%)                                             
      Fatty Change, Focal                              1 (2%)                    1 (2%)                                             
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)       1 (4%)                                                          
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Infarct, Single                                  1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Histiocyte    1 (2%)                                                                       
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Karyomegaly, Multifocal                          1 (2%)                                                                       
      Necrosis, Acute, Focal                                        3 (13%)      1 (2%)                                             
      Necrosis, Acute, Multifocal                      2 (4%)       2 (9%)       2 (4%)                                             
      Necrosis, Multifocal, Subacute                   1 (2%)                                                                       
      Syncytial Alteration, Focal                                                1 (2%)                                             
      Syncytial Alteration, Multifocal                 1 (2%)                                                                       
      Median Lobe, Congestion, Diffuse                 1 (2%)                                                                       
      Median Lobe, Fibrosis                            1 (2%)                                                                       
      Median Lobe, Thrombosis                          1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Median Lobe, Hepatocyte, Atrophy, Diffuse        1 (2%)                                                                       
   Mesentery                                          (6)                       (3)                                                 
      Infiltration Cellular, Multifocal, Lymphocyte    2 (33%)                   1 (33%)                                            
      Inflammation, Acute, Focal                       1 (17%)                                                                      
      Artery, Adventitia, Infiltration Cellular,                                                                                    
           Focal, Mixed Cell                           1 (17%)                                                                      
      Fat, Inflammation, Chronic Active, Focal                                   1 (33%)                                            
   Pancreas                                           (49)         (9)          (49)                                                
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                    2 (4%)                                             
      Acinus, Atrophy, Multifocal                      1 (2%)                                                                       
      Acinus, Hyperplasia, Focal                       1 (2%)                                                                       
      Acinus, Hypertrophy, Focal                                                 1 (2%)                                             
      Acinus, Hypertrophy, Multifocal                  1 (2%)                                                                       
      Artery, Inflammation, Chronic Active, Focal      1 (2%)                                                                       
   Salivary Glands                                    (50)         (11)         (50)                                                
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte   24 (48%)      2 (18%)     24 (48%)                                            
   Stomach, Forestomach                               (48)         (10)         (47)                                                
      Hyperplasia, Focal, Squamous                     1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                   1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (47)         (11)         (49)                                                
      Inflammation, Chronic Active, Focal                                        1 (2%)                                             
      Inflammation, Chronic Active, Multifocal                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (50)                                                
      Cardiomyopathy                                                1 (8%)       1 (2%)                                             
      Artery, Embolus, Single                          1 (2%)                                                                       
      Artery, Inflammation, Chronic Active                          1 (8%)                                                          
      Coronary Artery, Infiltration Cellular,                                                                                       
          Focal, Mixed Cell                            1 (2%)                                                                       
      Mitral Valve, Pigmentation, Focal,                                                                                            
          Hemosiderin                                  1 (2%)                                                                       
      Myocardium, Inflammation, Chronic Active,                                                                                     
           Multifocal                                  1 (2%)                                                                       
      Perivascular, Inflammation, Acute, Focal         1 (2%)                                                                       
      Ventricle, Karyomegaly, Multifocal               1 (2%)                                                                       
      Ventricle Left, Bacterium                        1 (2%)                                                                       
      Ventricle Left, Inflammation, Focal, Subacute    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (10)         (48)                                                
      Capsule, Hyperplasia, Focal                      3 (6%)                    2 (4%)                                             
      Capsule, Hyperplasia, Multifocal                36 (73%)      3 (30%)     39 (81%)                                            
   Adrenal Gland, Cortex                              (49)         (10)         (48)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                    3 (6%)                                             
      Hyperplasia, Focal                               5 (10%)                   7 (15%)                                            
      Hyperplasia, Multifocal                          6 (12%)                   5 (10%)                                            
      Hypertrophy, Focal                               7 (14%)      1 (10%)      8 (17%)                                            
      Hypertrophy, Multifocal                          6 (12%)                   3 (6%)                                             
   Adrenal Gland, Medulla                             (49)         (9)          (47)                                                
      Hyperplasia, Focal                               1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (9)          (49)                                                
      Hyperplasia, Focal                                                         2 (4%)                                             
      Hyperplasia, Multifocal                          7 (14%)      1 (11%)      4 (8%)                                             
   Parathyroid Gland                                  (36)         (6)          (35)                                                
      Infiltration Cellular, Focal, Lymphocyte                                   1 (3%)                                             
   Pituitary Gland                                    (45)         (11)         (47)                                                
      Pars Distalis, Cyst                              2 (4%)                    2 (4%)                                             
   Thyroid Gland                                      (49)         (9)          (47)                                                
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Ultimobranchial Cyst                             1 (2%)                    2 (4%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
      Follicular Cell, Hyperplasia, Multifocal         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (1)                                                 
      Inflammation, Chronic Active, Multifocal                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)                                                                           
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Preputial Gland                                    (15)         (6)          (8)                                                 
      Abscess                                          6 (40%)      1 (17%)                                                         
      Cyst                                             5 (33%)      1 (17%)      8 (100%)                                           
      Cyst Multilocular                                1 (7%)                                                                       
      Dilatation                                                    1 (17%)                                                         
      Inflammation, Chronic                            3 (20%)      3 (50%)                                                         
      Inflammation, Chronic Active                     7 (47%)                                                                      
   Prostate                                           (46)         (9)          (44)                                                
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                                                                       
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     3 (7%)       1 (11%)                                                         
   Seminal Vesicle                                    (48)         (17)         (49)                                                
      Dilatation                                       1 (2%)       1 (6%)                                                          
   Testes                                             (50)         (12)         (49)                                                
      Left, Hemorrhage                                                           1 (2%)                                             
      Seminiferous Tubule, Atrophy                     3 (6%)       1 (8%)       3 (6%)                                             
      Seminiferous Tubule, Degeneration, Multifocal    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (10)         (49)                                                
      Myeloid Cell, Hyperplasia                        5 (10%)      2 (20%)                                                         
   Lymph Node                                         (50)         (26)         (50)                                                
      Angiectasis, Focal                                            1 (4%)                                                          
      Bronchial, Hemorrhage                                                      1 (2%)                                             
      Inguinal, Hyperplasia, Lymphoid                               1 (4%)                                                          
      Inguinal, Hyperplasia, Re Cell                   1 (2%)                                                                       
      Lumbar, Hemorrhage                               1 (2%)                                                                       
      Lumbar, Hyperplasia, Lymphoid                    1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                            1 (4%)       1 (2%)                                             
   Lymph Node, Mandibular                             (47)         (11)         (35)                                                
      Hyperplasia, Lymphoid                                                      2 (6%)                                             
      Hyperplasia, Re Cell                             3 (6%)                    3 (9%)                                             
   Lymph Node, Mesenteric                             (42)         (19)         (33)                                                
      Hematopoietic Cell Proliferation                 6 (14%)      4 (21%)                                                         
      Hemorrhage                                      25 (60%)     12 (63%)     14 (42%)                                            
      Hyperplasia                                                   1 (5%)                                                          
      Hyperplasia, Lymphoid                                         1 (5%)       2 (6%)                                             
      Hyperplasia, Re Cell                             2 (5%)                    3 (9%)                                             
   Spleen                                             (49)         (14)         (49)                                                
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Depletion Lymphoid                               1 (2%)                                                                       
      Hematopoietic Cell Proliferation                11 (22%)      6 (43%)      2 (4%)                                             
      Hyperplasia, Diffuse, Lymphoid                                             1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Hyperplasia, Re Cell                             1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)                                             
      Lymphocyte, Necrosis, Multifocal                                           1 (2%)                                             
   Thymus                                             (35)         (6)          (34)                                                
      Cyst, Multiple                                                             1 (3%)                                             
      Depletion Lymphoid                               1 (3%)       1 (17%)      1 (3%)                                             
      Hyperplasia, Diffuse, Lymphoid                                             1 (3%)                                             
      Inflammation, Acute                                           1 (17%)                                                         
      Syncytial Alteration                             1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (30)         (49)                                                
      Inflammation, Chronic Active                     1 (2%)       1 (3%)       1 (2%)                                             
      Ulcer                                                         1 (3%)                                                          
      Prepuce, Abscess                                              2 (7%)                                                          
      Prepuce, Inflammation, Chronic Active                         1 (3%)                                                          
      Prepuce, Necrosis                                3 (6%)                                                                       
      Prepuce, Ulcer                                   2 (4%)       2 (7%)                                                          
      Scrotal, Pigmentation, Focal, Melanin                         1 (3%)                                                          
      Scrotal, Hair Follicle, Hyperplasia, Focal                    1 (3%)                                                          
      Subcutaneous Tissue, Abscess                                  1 (3%)                                                          
      Subcutaneous Tissue, Cyst                        1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                    1 (3%)                                                          
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Granulomatous                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)                                                
      Hyperostosis                                     1 (2%)                                                                       
      Osteoporosis, Focal                                                        1 (2%)                                             
      Sternum, Developmental Malformation              1 (2%)                                                                       
   Skeletal Muscle                                                 (1)          (1)                                                 
      Arteriole, Inflammation, Chronic Active                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
      Hydrocephalus                                    1 (2%)                                                                       
      Mineralization, Focal                            1 (2%)                                                                       
      Mineralization, Multifocal                      26 (52%)      5 (45%)     21 (42%)                                            
      Artery, Meninges, Inflammation, Chronic,                                                                                      
           Multifocal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (44)         (6)          (46)                                                
      Inflammation, Acute, Diffuse                                               1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
   Lung                                               (50)         (49)         (49)                                                
      Congestion                                                    1 (2%)       1 (2%)                                             
      Granuloma                                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Infiltration Cellular, Diffuse, Histiocyte       1 (2%)                                                                       
      Infiltration Cellular, Focal, Histiocyte                      2 (4%)       1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    5 (10%)      1 (2%)       3 (6%)                                             
      Infiltration Cellular, Multifocal, Histiocyte                 3 (6%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       2 (4%)                                                          
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
           Histiocyte                                                            1 (2%)                                             
      Alveolus, Inflammation, Chronic Active, Focal                 1 (2%)       1 (2%)                                             
      Alveolus, Inflammation, Chronic Active,                                                                                       
          Multifocal                                                             3 (6%)                                             
      Bronchiole, Hyperplasia, Focal                                1 (2%)                                                          
      Bronchiole, Hyperplasia, Multifocal                           4 (8%)                                                          
      Bronchiole, Inflammation, Chronic, Focal                      1 (2%)                                                          
      Bronchiole, Alveolus, Inflammation, Chronic,                                                                                  
           Multifocal                                               1 (2%)                                                          
      Bronchiole, Alveolus, Inflammation, Chronic                                                                                   
          Active, Focal                                             3 (6%)       1 (2%)                                             
      Bronchiole, Alveolus, Inflammation, Chronic                                                                                   
          Active, Multifocal                                       12 (24%)     29 (59%)                                            
      Interstitium, Inflammation, Acute, Focal         1 (2%)                                                                       
      Mediastinum, Infiltration Cellular,                                                                                           
          Multifocal, Lymphocyte                                    1 (2%)       2 (4%)                                             
      Pleura, Hyperplasia, Diffuse                                               1 (2%)                                             
      Pleura, Infiltration Cellular, Lymphocyte                     1 (2%)                                                          
   Nose                                               (50)         (48)         (49)                                                
      Mucosa, Inflammation, Acute                      3 (6%)                    1 (2%)                                             
      Mucosa, Inflammation, Chronic                    1 (2%)                                                                       
      Mucosa, Inflammation, Chronic Active             2 (4%)      47 (98%)     48 (98%)                                            
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                    1 (2%)                                                          
      Respiratory Epithelium, Hyperplasia              5 (10%)     48 (100%)    49 (100%)                                           
   Trachea                                            (49)         (9)          (48)                                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Glands, Hyperplasia, Diffuse                                               2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Left, Inflammation, Chronic Active                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05070-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:07:43  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      10 PPM       25 PPM                                                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (11)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Cyst, Single                                     1 (2%)                                                                       
      Degeneration, Chronic, Focal, Two                                          1 (2%)                                             
      Degeneration, Chronic, Multifocal                                          1 (2%)                                             
      Embolus, Multifocal                              1 (2%)                                                                       
      Hydronephrosis                                   3 (6%)                    1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    9 (18%)                   3 (6%)                                             
      Infiltration Cellular, Multifocal, Mixed Cell    1 (2%)                                                                       
      Inflammation, Acute, Focal                                    1 (9%)                                                          
      Inflammation, Acute, Multifocal, Suppurative     1 (2%)                                                                       
      Inflammation, Chronic Active, Multifocal,                                                                                     
           Suppurative                                 2 (4%)       1 (9%)                                                          
      Mineralization, Focal                            1 (2%)                                                                       
      Mineralization, Multifocal                                    1 (9%)                                                          
      Nephropathy, Chronic                                          1 (9%)       3 (6%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
      Capsule, Fibrosis, Multifocal                                 1 (9%)                                                          
      Cortex, Renal Tubule, Epithelium,                                                                                             
          Hyperplasia, Atypical, Focal                 1 (2%)                                                                       
   Urethra                                            (1)                                                                           
      Calculus Micro Observation Only                  1 (100%)                                                                     
   Urinary Bladder                                    (49)         (27)         (47)                                                
      Calculus Micro Observation Only                  2 (4%)                                                                       
      Embolus                                          1 (2%)                                                                       
      Inflammation, Chronic Active, Diffuse            1 (2%)       1 (4%)                                                          
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
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