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TDMS Study 05070-02 Pathology Tables

NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28




       Facility:  Midwest Research Institute

       Chemical CAS #:  25013154

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  M  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Serosa, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Serosa, Lymphoma Malignant Mixed     |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     A  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +     +  +  +     +  +  +  +     +  +        +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Hepatocellular Carcinoma             |          X                 X                    X  X                     |             
      Hepatocellular Adenoma               |                                                    X                     |             
      Lymphoma Malignant Histiocytic       |          X                                                  X            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                       +        +     +                 +      |             
      Lymphoma Malignant Histiocytic       |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |       X                 X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                      X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Glandular, Lymphoma Malignant Mixed  |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Hamartoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Atrium Left, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                             X            |             
      Atrium Left, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  M  M  +  M  M  +     M  M  +  M  +  +  +     M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  M  +  +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |                                                          X  X            |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                                      X   |             
      Hemangioma                           |                               X                                          |             
      Lymphoma Malignant Histiocytic       |                                                             X            |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |       X                 X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Granulosa Cell Tumor Malignant,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Metastatic, Uterus               |                                                                      X   |             
      Lymphoma Malignant Histiocytic       |          X                                                  X            |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Mixed             |                                                    X                     |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |          X                                                               |             
      Axillary, Lymphoma Malignant Mixed   |       X                                                                  |             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |       X                                                                  |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Mediastinal, Lymphoma Malignant Mixed|       X                                         X                        |             
      Pancreatic, Lymphoma Malignant Mixed |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  M  +  +  +  +  M     +  +  +  +  +  +  +     M  +  +|             
      Lymphoma Malignant Histiocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |       X                 X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  +  +  +  +  +  +  +     +  +  +  +  M  M  M     +  M  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |       X                 X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +|             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     M  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Alveolar/Bronchiolar Carcinoma       |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |       X                                         X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pleura, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma, Papillary                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |       +                    +  +              +  +                    +   |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|             
                                           | 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |          X                                                               |             
      Lymphoma Malignant Lymphocytic       |                            X                                      X      |             
      Lymphoma Malignant Mixed             |       X                 X                       X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |          X                                                  X            |             
      Lymphoma Malignant Lymphocytic       |                            X                                      X      |             
      Lymphoma Malignant Mixed             |       X                 X                       X  X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  M  M  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Serosa, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Serosa, Lymphoma Malignant Mixed     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  42        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hepatocellular Carcinoma             |          X                                   X                           |          6 |
      Hepatocellular Adenoma               |                               X  X                                   X   |          4 |
      Lymphoma Malignant Histiocytic       |                                                          X               |          3 |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                            X                                X            |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                    +  +            |   8        |
      Lymphoma Malignant Histiocytic       |                                                          X               |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                +         |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Glandular, Lymphoma Malignant Mixed  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hamartoma                            |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrium Left, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Atrium Left, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Lymphoma Malignant Histiocytic       |                                                          X               |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +   |  45        |
      Pheochromocytoma Benign              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  M  +  +  M  +  M  M  M  +  +  +  +  +  M  +|  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Adenoma               |       X                             X        X     X        X        X   |          8 |
      Pars Intermedia, Adenoma             |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Follicular Cell, Adenoma             |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                   +                                                      |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                          X               |          2 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Granulosa Cell Tumor Malignant,      |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                          X               |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                            X                                X            |          2 |
      Polyp Stromal                        |                   X                 X                                    |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Undifferentiated Cell Type       |                                                             X            |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                             X            |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Lymphocytic       |                                     X                 X                  |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  M  I  +  +  +  +  +  +  +  +  M  +  M  +  M  +|  38        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                                                 X     X                  |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Lymphoma Malignant Histiocytic       |                                                          X               |          1 |
      Lymphoma Malignant Lymphocytic       |                               X     X           X                        |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenocarcinoma                       |                   X                                            X         |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  M  M  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3|            |
                                           | 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Gland                            |                                                                X         |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                      X   |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                          X               |          1 |
      Lymphoma Malignant Lymphocytic       |    X                          X                       X                  |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                            X                                X            |          2 |
      Pleura, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   1        |
      Adenoma, Papillary                   |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                 +           +  +     +   |  10        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                          X               |          2 |
      Lymphoma Malignant Lymphocytic       |                                     X           X     X                  |          5 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |
      Lymphoma Malignant Lymphocytic       |    X                                                  X                  |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                            X                                             |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                          X               |          3 |
      Lymphoma Malignant Lymphocytic       |    X                          X     X           X     X                  |          7 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                            X                                X            |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  M  M  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +     +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +     +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  A  +  +  +  +     +  +  A  +  +  +  +  +  +     +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                      X                                   X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Plasma Cell Tumor Malignant          |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Plasma Cell Tumor Malignant          |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  M  +  M  M  M  +  M  +  +  M  +  +  M  +  M  M  M  M|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Plasma Cell Tumor Malignant          |                                                    X                     |             
      Bilateral, Lymphoma Malignant Mixed  |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Plasma Cell Tumor Malignant          |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                       X                  |             
      Lumbar, Lymphoma Malignant Mixed     |                                                       X                  |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
      Plasma Cell Tumor Malignant          |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  I  +  +     M  +  M  +  M  +  +  M  +  M  +  M  M  M  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Plasma Cell Tumor Malignant          |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X                                                         |             
      Alveolar/Bronchiolar Carcinoma       |             X     X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
      Pleura, Mediastinum, Plasma Cell     |                                                                          |             
          Tumor Malignant                  |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|             
                                           | 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Plasma Cell Tumor Malignant          |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                        +                                +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  M  M  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +|  42        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +        +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +     +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                   X                       X                              |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   2        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Plasma Cell Tumor Malignant          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       | X                                         X                              |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       | X                                         X                              |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Plasma Cell Tumor Malignant          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       | X                 X                                                      |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  M  M  +     +  M  M  M  M  M  +  +  M  +  +  +  +  M  +  +|  25        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Adenoma               | X                                                                 X      |          2 |
      Pars Intermedia, Adenoma             |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +     +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +|  42        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Lymphoma Malignant Lymphocytic       | X                 X                       X                              |          3 |
      Plasma Cell Tumor Malignant          |                                                                          |          1 |
      Bilateral, Lymphoma Malignant Mixed  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Plasma Cell Tumor Malignant          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                            X                                             |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Plasma Cell Tumor Malignant          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +  +  M  M  M  M  +  +  +  +  +  +  +  M  +  M|  32        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       | X                 X                       X                              |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Lymphoma Malignant Lymphocytic       | X                                         X                              |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  M  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  M  +  +     +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
      Plasma Cell Tumor Malignant          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                   X                       X                              |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Pleura, Mediastinum, Plasma Cell     |                                                                          |            |
          Tumor Malignant                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
      Plasma Cell Tumor Malignant          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
      Carcinoma                            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          | +                          +                                      +      |   5        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Lymphoma Malignant Lymphocytic       | X                                         X                              |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |          X                                            X                  |          2 |
      Lymphoma Malignant Lymphocytic       | X                 X        X              X                              |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|             
                                           | 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                 +                        |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                 +     +        +         |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                 +              +         |             
      Polyp Adenomatous                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                 +                        |             
                                            __________________________________________________________________________|             
   Liver                                   |                      +  +  +              +  +  +              +        +|             
      Hemangiosarcoma                      |                                                                X         |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                           X                              |             
      Hepatocellular Adenoma               |                      X                       X                           |             
      Lymphoma Malignant Histiocytic       |                            X                                            X|             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +           +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                 +                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                 M                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                              +  +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                              +  +                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                              +  +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                 +                        |             
      Extra Adrenal Tissue, Lymphoma       |                                                                          |             
          Malignant Undifferentiated Cell  |                                                                          |             
          Type                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                 M                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                 M                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                 +                        |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +                                         +                        |             
      Pars Distalis, Adenoma               |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|             
                                           | 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +              +                 +     +        +              +         |             
      Adenoma                              |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +           +  +  +  +  +  +     +  +     +     +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Polyp Stromal                        |                                     X                                    |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                 +                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                       +                        |             
      Lumbar, Lymphoma Malignant Mixed     |                         X                                                |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                 M                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +                       +                        |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                         +  +              +     +     +                 +|             
      Hemangiosarcoma                      |                                           X                              |             
      Lymphoma Malignant Histiocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                         X                             X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                         +                       M                        |             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                 +                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +              +     +  +  +     +     +     +     +        +         |             
      Subcutaneous Tissue, Fibrosarcoma    |                   X                                                      |             
      Subcutaneous Tissue, Hemangioma      |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +           +                                +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|             
                                           | 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                                 +                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic |                                                                          |             
      Lymphoma Malignant Histiocytic       |                            X                                            X|             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |             
      Pleura, Lymphoma Malignant Mixed     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                         +  +                    +              +         |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Lymphoma Malignant Histiocytic       |                            X                                            X|             
      Lymphoma Malignant Mixed             |                         X                             X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3|            |
                                           | 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                           +                          +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                              +           +           +   |   6        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                      +   |   3        |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                      A   |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +        +  +  +     +        +                          +   |  16        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Spleen  |                            X                                             |          1 |
      Hepatocellular Carcinoma             |                         X        X                                       |          2 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                           +                          +   |   3        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                      +   |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                      +   |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                      +   |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                        +                             +   |   3        |
      Extra Adrenal Tissue, Lymphoma       |                                                                          |            |
          Malignant Undifferentiated Cell  |                                                                          |            |
          Type                             |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                        +                             +   |   2        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                        +                             +   |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                           +                          +   |   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3|            |
                                           | 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +        +                                                     +   |   5        |
      Pars Distalis, Adenoma               |       X        X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +           +           +  +  +              +                    +  +|  14        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +     +  +  +  +        +     +  +     +  +  +  +  +  +  +  +|  37        |
      Hemangiosarcoma, Metastatic, Spleen  |                            X                                             |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Polyp Stromal                        |                                                                          |          1 |
      Sarcoma Stromal                      |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +  +  +     +                 +           +   |   8        |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            +     +     +                 +           M   |   6        |
      Lymphoma Malignant Mixed             |                                  X                                       |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +              +     +     +     +                       +   |  13        |
      Hemangiosarcoma                      |             X              X                                             |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                      +   |   2        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3|            |
                                           | 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +        +  +        +           +           +     +              +   |  20        |
      Subcutaneous Tissue, Fibrosarcoma    | X                                                                        |          2 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +              +     +           +  +     +     +     +     +   |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                                      M   |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |          2 |
      Hepatocellular Carcinoma, Metastatic |                         X                                                |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant Mixed|                                  X                                       |          1 |
      Pleura, Lymphoma Malignant Mixed     |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                      +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                      +     +                                         +   |   7        |
      Hemangiosarcoma, Metastatic, Spleen  |                            X                                             |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                      +   |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                      X           X           X                           |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                               X        X                                 |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|             
                             DAY ON TEST   | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|             
                                           | 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Multiple            |                                     X                                    |             
      Hepatocellular Carcinoma             |             X     X     X                                            X   |             
      Hepatocellular Carcinoma, Multiple   | X                                                                        |             
      Hepatocellular Adenoma               |                                        X        X  X                     |             
      Hepatocellular Adenoma, Multiple     |                                           X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +        +  +                                                      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma, Multiple           |                                           X                              |             
      Capsule, Lymphoma Malignant Mixed    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|             
                             DAY ON TEST   | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|             
                                           | 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Adenoma               |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Follicular Cell, Adenocarcinoma      |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       | +                                                                        |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +     +     +  +           +        +     +  +        +         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                            X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|             
                             DAY ON TEST   | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|             
                                           | 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  +  +  M  M  +  M  M  M  M  +  M  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Hamartoma                  |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X  X                                      X                 X     X|             
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                X                                                         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X           X                                                            |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X                                         X                     |             
      Lymphoma Malignant Mixed             |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  M  +  A  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  46        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +     +  +  M  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +|  46        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatocellular Carcinoma             |                   X           X        X                       X  X      |          9 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |    X                                               X           X         |          6 |
      Hepatocellular Adenoma, Multiple     |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                              +         |   6        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Capsule, Adenoma, Multiple           |                                                                          |          1 |
      Capsule, Lymphoma Malignant Mixed    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  49        |
      Adenoma                              |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  49        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  M  M  +  M  +  +  +  +  M  M  +  M  +  +  +  +  M  +  M  +|  36        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  45        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenocarcinoma      |                                                                X         |          1 |
      Follicular Cell, Adenoma             | X                    X                                X                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                       +  +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +|  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      | X                                                                        |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  M  +  +|  42        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  M  +  +  M  +  +  +  +  M  +  +  M  M  A  +  M  +  +  +|  35        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  +  M|  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteoma                              |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Hamartoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  M|  44        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                  X  X  X  X                              |          9 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         | X                                                                        |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                               X                                          |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                  +                                       |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3|            |
                                           | 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                   X  X                                                   |          2 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Serosa, Sarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                         X                 X        X                     |             
      Hepatocellular Carcinoma, Multiple   |                   X                                                      |             
      Hepatocellular Adenoma               |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +              +                    +                        |             
      Fat, Hemangiosarcoma                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Sarcoma, Metastatic,        |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +  +                    +            |             
                                            __________________________________________________________________________|             
   Prostate                                | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Sarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Sarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  M  M  +  +  +  +        +  +  +  +  +  +  +  +  M  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Sarcoma, Metastatic,        |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  +  +  M  M  M  M  M  M  M  +  +  +  +  +  +  +  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                 X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    25 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  M  M  A  M  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M  A  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Serosa, Sarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Polyp Adenomatous                    |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     M  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Hepatocellular Carcinoma             |                            X     X                    X                 X|          7 |
      Hepatocellular Carcinoma, Multiple   |       X                 X                                X        X      |          5 |
      Hepatocellular Adenoma               |                                     X              X                     |          2 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Hemangiosarcoma                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|  48        |
      Capsule, Sarcoma, Metastatic,        |                                                                          |            |
          Uncertain Primary Site           |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|  47        |
      Pheochromocytoma Benign              |                                                             X            |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  M  +  M  +  +  +  +  M  +  M  M  +  +  +  +  +  M  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +|  47        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +        +                 +  +                 +               |   8        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  44        |
      Serosa, Sarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  49        |
      Serosa, Sarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  M  +  M  M  M  +  M  +  +  +  M  +  M  M  +  +  +  M  +  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  M  M  M  M  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  M|  33        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Sarcoma, Metastatic,        |                                                                          |            |
          Uncertain Primary Site           |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  M  M  M  +  +  I  +  +  +  M  +  +  M  M  +  +  M  +  M|  34        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  +  +  M  M  M  M  +  M  M  +  M  +  M  +  +  M  +  +  M  M  M|  21        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                       X                  |          1 |
      Subcutaneous Tissue, Hemangioma      |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    25 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +           +  +  +                 M        +                     |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +           +  +  +  +              M                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M     +           +  +  +                 +        A                     |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +           +  +  +                 M        A                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +           +  +  +     +           +        +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +           +  +  +     +           +        A                     |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +           +  +  +     +           +        A                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +           +  +  +     +           +        A                     |             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +     +           +  +     +  +                  |             
      Hepatocellular Carcinoma             |    X  X     X     X  X                       X     X                     |             
      Hepatocellular Carcinoma, Multiple   |                         X                                                |             
      Hepatocellular Adenoma               |                                                       X                  |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +           +  +  +                 +        A                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +           +  +  +                 +        +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +           +  +  +                 +        +              +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +           +  +  +                 +     +  +                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +           M  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +           +  +  +                 +        A                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     M           M  +  +                 M        +                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +           +  +  +                 M        +                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +           +  +  +                 +        +                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                            +                    +   |             
                                            __________________________________________________________________________|             
   Prostate                                | M     +           +  +  +                 +        +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +     +     +  +  +  +              M        +              +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +           +  +  +                 +        +                     |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +           +  +  +                 M        +                     |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +           +  +  +     +        +  +  +     +  +     +           +|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M     +           +  +  +                 +        M                    +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +           +  +  +     +        +  M  +     M  +     +           +|             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +  +                 +        A                    +|             
      Hemangiosarcoma                      |          X                                                               |             
      Lymphoma Malignant Histiocytic       |    X                 X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +           M  M  +                 M        M                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     M           M  M  M                 M        M                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +        +  +  +  +     +  +     +  +  +  +  +  +        +  +   |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +           +  +  +                 M        +                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +           +  +  +                 +        +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | M     +           +  +  M                 M        M                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                  X                             X         |             
      Alveolar/Bronchiolar Carcinoma       |                                              X                           |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                           X                              |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                         X                                                |             
      Lymphoma Malignant Histiocytic       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +           +  +  +                 M        +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +           +  +  +                 +     +  +                     |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +     +  +  +  +        +     +        +        +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |    X                 X                                                   |             
      Lymphoma Malignant Mixed             |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3|            |
                                           | 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                             M              +  +                     |   9        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +                             A  A        +  +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +                             +              +  +                     |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                             A              M  +                     |   7        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +                             A              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +                             A              +  +                     |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                          +  +           +  +  +                     |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +                             A           +  +  M                     |  10        |
      Polyp Adenomatous                    |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                             M              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    M                          +  M              +  +                     |  10        |
      Adenocarcinoma                       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | A  +     +        +     +        +  +     +  +  +  +     +               |  23        |
      Hepatocellular Carcinoma             |    X              X     X           X                                    |         11 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                           X                              |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                             A              +  +                     |   9        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                             +              +  +                     |  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +                             A              +  +                     |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | A  +                             A              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +                             A              +  +                     |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                             +              +  +                     |  13        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                             A              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                             A              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                             A              +  +                     |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                             A              +  +                     |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | A  +                             M              +  +                     |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +                             +              +  +                     |  11        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | A  +                             M              +  +                     |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3|            |
                                           | 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | A  +                             +              +  +                     |  11        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                    A     +        +                        |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +                             A              +  +                     |   9        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +           +                 +        +     +  +     +               |  17        |
                                            __________________________________________________________________________|____________|
   Testes                                  | A  +                             +              +  +                    +|  12        |
      Interstitial Cell, Adenoma           |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                             +              +  +                     |  10        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +     +           +  +     +  +  +  +  +     +               |  26        |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +        +     +              +              +  M                     |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +     +  +     +           +  M           +  +  +                     |  19        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +                    +        A           +  +  +                     |  14        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M                             A        +     +  +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                             M              M  M                     |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | A  +           +  +  +  +  +  +  +           +  +  +              +     +|  30        |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                             +              +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                             +              +  +                     |  11        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +                                            +  +                     |   6        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05070-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:44:28  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3|            |
                                           | 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                   X                                                      |          2 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                   X     X           X                                    |          4 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | A  +                             M              +  +                     |   9        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   1        |
      Bilateral, Adenoma                   |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | A  +                             A              +  +                     |  11        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +     +  +           +  A     +  +  +  +  +  +  +        +  +   |  27        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
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