TDMS Study 05070-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) VINYL TOLUENE NTP Experiment-Test: 05070-02 Report: PEIRPT05 Study Type: CHRONIC Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 Facility: Midwest Research Institute Chemical CAS #: 25013154 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund Sacrifice 6 10 1 Natural Death 8 2 7 Accidently Killed 1 2 Dosing Accident 6 Survivors Terminal Sacrifice 36 37 34 Animals Examined Microscopically 48 49 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (48) (1) (47) Gallbladder (38) (2) (42) Intestine Large, Colon (47) (2) (46) Intestine Large, Rectum (47) (1) (40) Intestine Small (46) (6) (47) Intestine Small, Duodenum (45) (3) (44) Polyp Adenomatous 1 (33%) Liver (48) (16) (49) Hemangiosarcoma 1 (6%) Hemangiosarcoma, Metastatic, Spleen 1 (6%) Hepatocellular Carcinoma 6 (13%) 2 (13%) Hepatocellular Carcinoma, Multiple 1 (6%) Hepatocellular Adenoma 4 (8%) 2 (13%) 2 (4%) Mesentery (8) (3) (2) Plasma Cell Tumor Malignant 1 (50%) Pancreas (47) (3) (49) Salivary Glands (48) (1) (48) Plasma Cell Tumor Malignant 1 (2%) Stomach, Forestomach (47) (3) (45) Stomach, Glandular (47) (3) (47) Hamartoma 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (48) (2) (48) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (47) (3) (49) Adrenal Gland, Cortex (47) (2) (48) Adrenal Gland, Medulla (45) (2) (47) Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (47) (3) (49) Carcinoma 1 (33%) Parathyroid Gland (29) (1) (25) Pituitary Gland (46) (5) (47) Pars Distalis, Adenoma 8 (17%) 3 (60%) 2 (4%) Pars Intermedia, Adenoma 1 (2%) 1 (2%) Thyroid Gland (48) (2) (42) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (46) (14) (44) Adenoma 1 (7%) Granulosa Cell Tumor Malignant 1 (2%) Hemangioma 1 (2%) Plasma Cell Tumor Malignant 1 (2%) Uterus (48) (37) (45) Granulosa Cell Tumor Malignant, Metastatic, Uterus 1 (2%) Hemangiosarcoma, Metastatic, Spleen 1 (3%) Plasma Cell Tumor Malignant 1 (2%) Polyp Stromal 2 (4%) 1 (3%) Sarcoma Stromal 1 (3%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (47) (2) (47) Lymph Node (48) (8) (49) Lymph Node, Mandibular (45) (1) (43) Plasma Cell Tumor Malignant 1 (2%) Lymph Node, Mesenteric (38) (6) (32) Spleen (47) (13) (49) Hemangiosarcoma 3 (23%) Thymus (40) (2) (42) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (47) (1) (44) Adenocarcinoma 2 (4%) Skin (46) (20) (47) Subcutaneous Tissue, Fibrosarcoma 2 (10%) Subcutaneous Tissue, Hemangioma 1 (5%) Subcutaneous Tissue, Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (40) (1) (40) Plasma Cell Tumor Malignant 1 (3%) Lung (48) (49) (49) Adenocarcinoma, Metastatic, Mammary Gland 1 (2%) Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%) 2 (4%) Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) Hepatocellular Carcinoma, Metastatic 1 (2%) Pleura, Mediastinum, Plasma Cell Tumor Malignant 1 (2%) Trachea (48) (2) (47) Plasma Cell Tumor Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (1) (1) Adenoma, Papillary 1 (100%) Carcinoma 1 (100%) Lacrimal Gland (10) (5) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (48) (7) (49) Hemangiosarcoma, Metastatic, Spleen 1 (14%) Urinary Bladder (45) (2) (40) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(48) *(49) *(50) Lymphoma Malignant Histiocytic 3 (6%) 2 (4%) 2 (4%) Lymphoma Malignant Lymphocytic 7 (15%) 4 (8%) Lymphoma Malignant Mixed 4 (8%) 5 (10%) 1 (2%) Lymphoma Malignant Undifferentiated Cell 2 (4%) 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 29 27 17 Total Primary Neoplasms 48 31 27 Total Animals with Benign Neoplasms 16 11 7 Total Benign Neoplasms 22 11 7 Total Animals with Malignant Neoplasms 22 18 12 Total Malignant Neoplasms 26 20 20 Total Animals with Metastatic Neoplasms 2 2 Total Metastatic Neoplasm 2 4 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund Sacrifice 10 13 4 Natural Death 6 7 2 Accidently Killed 1 1 Dosing Accident 2 Survivors Terminal Sacrifice 33 30 41 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (49) (9) (48) Intestine Large, Cecum (46) (7) (44) Intestine Large, Colon (48) (10) (47) Serosa, Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Intestine Small, Duodenum (47) (10) (49) Polyp Adenomatous 1 (10%) 1 (2%) Intestine Small, Jejunum (46) (10) (44) Adenocarcinoma 1 (10%) Liver (50) (23) (48) Hemangiosarcoma, Multiple 1 (2%) Hepatocellular Carcinoma 9 (18%) 11 (48%) 7 (15%) Hepatocellular Carcinoma, Multiple 1 (2%) 1 (4%) 5 (10%) Hepatocellular Adenoma 6 (12%) 2 (9%) 2 (4%) Hepatocellular Adenoma, Multiple 2 (4%) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Mesentery (6) (3) Fat, Hemangiosarcoma 1 (33%) Pancreas (49) (9) (49) Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Salivary Glands (50) (11) (50) Stomach, Forestomach (48) (10) (47) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (49) (10) (48) Capsule, Adenoma, Multiple 1 (2%) Capsule, Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Adrenal Gland, Cortex (49) (10) (48) Adenoma 1 (2%) Adrenal Gland, Medulla (49) (9) (47) Pheochromocytoma Benign 1 (2%) 1 (2%) Islets, Pancreatic (49) (9) (49) Adenoma 2 (4%) Parathyroid Gland (36) (6) (35) Pituitary Gland (45) (11) (47) Pars Distalis, Adenoma 1 (2%) 1 (2%) Thyroid Gland (49) (9) (47) Follicular Cell, Adenocarcinoma 1 (2%) Follicular Cell, Adenoma 3 (6%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (49) (11) (49) Prostate (46) (9) (44) Serosa, Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Seminal Vesicle (48) (17) (49) Serosa, Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Testes (50) (12) (49) Interstitial Cell, Adenoma 1 (8%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (10) (49) Lymph Node (50) (26) (50) Lymph Node, Mandibular (47) (11) (35) Lymph Node, Mesenteric (42) (19) (33) Spleen (49) (14) (49) Hemangiosarcoma 1 (7%) Capsule, Sarcoma, Metastatic, Uncertain Primary Site 1 (2%) Page 8 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Thymus (35) (6) (34) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (30) (49) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Fibrous Histiocytoma 1 (3%) Subcutaneous Tissue, Hemangioma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (10) (50) Osteoma 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (11) (50) Meninges, Hamartoma 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (44) (6) (46) Lung (50) (49) (49) Alveolar/Bronchiolar Adenoma 9 (18%) 2 (4%) 2 (4%) Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (4%) Alveolar/Bronchiolar Carcinoma, Multiple 2 (4%) 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 3 (6%) 4 (8%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (1) Bilateral, Adenoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (11) (50) Urinary Bladder (49) (27) (47) Page 9 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Lymphoma Malignant Histiocytic 2 (4%) 2 (4%) Lymphoma Malignant Lymphocytic 3 (6%) Lymphoma Malignant Mixed 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 10 NTP Experiment-Test: 05070-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC VINYL TOLUENE Date: 09/09/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:07:46 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 10 PPM 25 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 33 23 20 Total Primary Neoplasms 48 28 25 Total Animals with Benign Neoplasms 21 7 10 Total Benign Neoplasms 26 7 11 Total Animals with Malignant Neoplasms 18 16 13 Total Malignant Neoplasms 22 21 14 Total Animals with Metastatic Neoplasms 3 4 1 Total Metastatic Neoplasm 3 4 7 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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