TDMS Study 05070-02 Pathology Tables
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
Facility: Midwest Research Institute
Chemical CAS #: 25013154
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|
| 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + A + + + + + + + + + + + + + A + +|
Dilatation | 4 |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active,| |
Multifocal | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + A + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Serosa, Ileum, Jejunum, Inflammation,| |
Chronic Active, Multifocal | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | |
Fatty Change, Diffuse | 1 |
Granuloma, Multifocal | 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | 4 4 |
Hepatodiaphragmatic Nodule | |
Infarct | 4 |
Infiltration Cellular, Diffuse, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Multifocal, Subacute | 1 1 1|
Necrosis, Multifocal | 2 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Multifocal| 2 |
Bile Duct, Hyperplasia, Focal | 1 |
Centrilobular, Necrosis, Diffuse | 3 |
Centrilobular, Necrosis, Multifocal | 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 1 |
Infiltration Cellular, Mixed Cell | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + M + + + + + + + + + + + + + + + +|
Cytomegaly, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|
| 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hypertrophy, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 3 |
Infiltration Cellular, Multifocal, | |
Mixed Cell | |
Inflammation, Chronic Active | 3 2 |
Acinus, Atrophy | 3 4 |
__________________________________________________________________________|
Pharynx | |
Palate, Ulcer, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 1 3 2 3 2 4 1 2 3|
Inflammation, Chronic Active, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Chronic Active, | |
Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Inflammation, Chronic Active, | |
Multifocal | |
Aortic Valve, Thrombosis | 2|
Atrium Left, Thrombosis | |
Mitral Valve, Inflammation, Chronic | |
Active, Focal | 3 |
Pericardium, Infiltration Cellular, | |
Multifocal, Mixed Cell | |
Valve, Pigmentation, Hemosiderin, | |
Multifocal | 2 |
Ventricle, Mineralization, Focal | |
Ventricle, Necrosis, Focal, Subacute | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|
| 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adrenal Gland, Accessory Adrenal | |
Cortical Nodule | |
Capsule, Hyperplasia, Diffuse | 3 4 3 2 |
Capsule, Hyperplasia, Multifocal | 2 2 3 4 4 2 3 2 4 2 4 2 2 3 3 2 2 2|
Capsule, Inflammation, Chronic | |
Active, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Degeneration, Fatty, Focal | 3 |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Medulla, Hematopoietic Cell | |
Proliferation, Multifocal | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy, Multifocal | 3 |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M M M + M M + M M + M + + + M + M|
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + M + + + + + + +|
Pars Distalis, Angiectasis, Focal | 3 2 2 |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia, | |
Multifocal | |
Pars Distalis, Hypertrophy, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1|
Inflammation, Chronic Active, Focal | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Focal | 2 |
Follicular Cell, Hyperplasia, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + M + + + + + + + + + + + + + + + +|
Abscess, Multiple | 4 |
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|
| 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 2 X 2 4 |
Hemorrhage, Focal | 3 4 |
Infiltration Cellular, Lymphocyte | 2 |
Thrombosis | 4 |
Periovarian Tissue, Infiltration | |
Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Single | 3 |
Adenomyosis | 2 |
Angiectasis | 4 |
Dilatation | 3 3 |
Hemorrhage, Acute | 4 |
Hyperplasia, Cystic | 3 4 2 3 2 3 1 3 3 2 3 1 1 2 1 2|
Inflammation, Chronic Active, | |
Multifocal | |
Thrombosis | |
Serosa, Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Bronchial, Depletion Lymphoid, | |
Diffuse | |
Bronchial, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | |
Hyperplasia, Re Cell | 3 |
Infiltration Cellular, Diffuse, | |
Polymorphonuclear | 3 |
Pigmentation, Diffuse, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M M + + + + M + + + + + + + M + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 4 |
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 4 3 4 2 |
Hyperplasia, Lymphoid | 2 4 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|
| 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infarct | |
Pigmentation, Hemosiderin | 2 2 |
Capsule, Abscess, Chronic | 4 |
Capsule, Ectopic Tissue | |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + M M + + + + + + + + + + + M M M + M +|
Depletion Lymphoid | 3 4 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Multifocal | |
Hyperplasia, Diffuse | |
Infiltration Cellular, Multifocal, | |
Mixed Cell | |
Inflammation, Chronic, Diffuse | 3 |
Inflammation, Chronic Active, Diffuse| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic Active, Diffuse| |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 2 |
Joint, Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute, Focal | 2 |
Hydrocephalus | 2 |
Inflammation, Acute, Focal | |
Mineralization, Multifocal | 2 1 2 1 2 2 2 2 2 2 1 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + + + + + + + + + + + + + + M + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Diffuse, | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|
| 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocyte | 1 3 |
Infiltration Cellular, Diffuse, | |
Mixed Cell | 3 |
Infiltration Cellular, Focal, | |
Histiocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Artery, Inflammation, Acute, | |
Multifocal | |
Mediastinum, Infiltration Cellular, | |
Multifocal, Lymphocyte | 3 |
Peribronchiolar, Inflammation, | |
Chronic Active, Multifocal | 1 |
Pleura, Inflammation, Chronic Active,| |
Multifocal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Mucosa, Inflammation, Chronic | 1 |
Mucosa, Inflammation, Chronic Active | 2 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 |
Olfactory Epithelium, Atrophy, Focal | 3 |
Respiratory Epithelium, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Cornea, Neovascularization | 3 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | + + + + + + |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 4 2 |
Infiltration Cellular, Multifocal, | |
Mixed Cell | |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 0| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 8| 3| 2| 3| 3| 3| 1| 9| 3| 3| 3| 9| 6| 3| 0| 4| 0| 3| 3|
| 5| 5| 5| 5| 3| 3| 9| 3| 8| 2| 2| 1| 4| 2| 2| 5| 5| 2| 9| 4| 5| 7| 9| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 3 2 2 2 1 3|
Capsule, Inflammation, Chronic Active| 3 2 |
Medulla, Epithelium, Karyomegaly, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 1 3 4 2 1 |
Infiltration Cellular, Multifocal, | |
Mixed Cell | |
Serosa, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3| |
| 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + M + + + + M + + M + M + M M + + +| 38 |
Dilatation | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +| 45 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Serosa, Inflammation, Chronic Active,| | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 4| 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 45 |
Serosa, Ileum, Jejunum, Inflammation,| | |
Chronic Active, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | | 1 1.0|
Granuloma, Multifocal | 1 | 2 1.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 3 3.3|
Hepatodiaphragmatic Nodule | X | 1 |
Infarct | | 1 4.0|
Infiltration Cellular, Diffuse, | | |
Lymphocyte | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1| 5 1.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Multifocal, Subacute | 1 1 1 1 1 | 8 1.0|
Necrosis, Multifocal | 4 | 2 3.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
Bile Duct, Hyperplasia, Focal | | 1 1.0|
Centrilobular, Necrosis, Diffuse | | 1 3.0|
Centrilobular, Necrosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3| |
| 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 2 2.0|
Infiltration Cellular, Mixed Cell | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cytomegaly, Multifocal | 2 | 2 2.0|
Hypertrophy, Focal | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 4 3 2 2 | 9 2.4|
Infiltration Cellular, Multifocal, | | |
Mixed Cell | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
Acinus, Atrophy | 4 | 3 3.7|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Ulcer, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 2 1 4 3 3 4 3 3 2 2 4 2 2 2 1 2 2 3 2| 32 2.4|
Inflammation, Chronic Active, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Developmental Malformation | X | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Pulp, Inflammation, Chronic Active, | | |
Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Bacterium | 4 | 1 4.0|
Inflammation, Chronic Active, | | |
Multifocal | 4 | 1 4.0|
Aortic Valve, Thrombosis | | 1 2.0|
Atrium Left, Thrombosis | 4 | 1 4.0|
Mitral Valve, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3| |
| 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Active, Focal | | 1 3.0|
Pericardium, Infiltration Cellular, | | |
Multifocal, Mixed Cell | 2 | 1 2.0|
Valve, Pigmentation, Hemosiderin, | | |
Multifocal | | 1 2.0|
Ventricle, Mineralization, Focal | 2 | 1 2.0|
Ventricle, Necrosis, Focal, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Adrenal Gland, Accessory Adrenal | | |
Cortical Nodule | X X | 2 |
Capsule, Hyperplasia, Diffuse | 2 2 4 3 3 3 3 3 3 | 13 2.9|
Capsule, Hyperplasia, Multifocal | 2 2 2 3 3 3 3 3 3 3 2 3 2 2 2 | 33 2.6|
Capsule, Inflammation, Chronic | | |
Active, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Accessory Adrenal Cortical Nodule | X X | 4 |
Degeneration, Fatty, Focal | 3 | 2 3.0|
Hyperplasia, Focal | 3 | 1 3.0|
Hypertrophy, Focal | 2 | 1 2.0|
Medulla, Hematopoietic Cell | | |
Proliferation, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + | 45 |
Hyperplasia, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy, Multifocal | | 1 3.0|
Hyperplasia, Multifocal | 3 3 3 2 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + M + M + + M + M M M + + + + + M +| 29 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Pars Distalis, Angiectasis, Focal | 2 2 3 2 | 7 2.3|
Pars Distalis, Hyperplasia, Focal | 1 2 4 3 | 4 2.5|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
Pars Distalis, Hypertrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Focal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3| |
| 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphocyte | | 1 1.0|
Inflammation, Chronic Active, Focal | 1 | 1 1.0|
Follicle, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia, Focal | | 1 2.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 |
Abscess, Multiple | | 1 4.0|
Atrophy | | 1 4.0|
Cyst | 3 X 3 X X | 9 2.8|
Hemorrhage, Focal | | 2 3.5|
Infiltration Cellular, Lymphocyte | 2 | 2 2.0|
Thrombosis | | 1 4.0|
Periovarian Tissue, Infiltration | | |
Cellular, Lymphocyte | 4 3 2 | 4 2.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess, Single | | 1 3.0|
Adenomyosis | | 1 2.0|
Angiectasis | | 1 4.0|
Dilatation | | 2 3.0|
Hemorrhage, Acute | | 1 4.0|
Hyperplasia, Cystic | 2 2 3 2 3 3 3 4 4 4 3 3 3 3 3 2 1 2 1 3| 36 2.5|
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
Thrombosis | X | 1 |
Serosa, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Bronchial, Depletion Lymphoid, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3| |
| 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Diffuse | 3 | 1 3.0|
Bronchial, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + +| 45 |
Hyperplasia, Lymphoid | 4 4 | 4 3.0|
Hyperplasia, Plasma Cell | 2 3 2 | 3 2.3|
Hyperplasia, Re Cell | | 1 3.0|
Infiltration Cellular, Diffuse, | | |
Polymorphonuclear | | 1 3.0|
Pigmentation, Diffuse, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + M I + + + + + + + + M + M + M +| 38 |
Hemorrhage | 3 2 | 3 2.3|
Hyperplasia, Lymphoid | 3 3 | 4 2.5|
Hyperplasia, Plasma Cell | | 1 4.0|
Hyperplasia, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 4 | 6 3.3|
Hyperplasia, Lymphoid | 3 2 4 3 | 6 3.0|
Infarct | 4 | 1 4.0|
Pigmentation, Hemosiderin | 2 | 3 2.0|
Capsule, Abscess, Chronic | | 1 4.0|
Capsule, Ectopic Tissue | X | 1 |
Capsule, Fibrosis, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + M + + + + + + + + + + + + + + + + + + +| 40 |
Depletion Lymphoid | 3 | 3 3.3|
Ectopic Parathyroid Gland | X X | 2 |
Hyperplasia, Lymphoid | | 1 2.0|
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
Ectasia, Multifocal | 2 | 1 2.0|
Hyperplasia, Diffuse | 2 3 | 2 2.5|
Infiltration Cellular, Multifocal, | | |
Mixed Cell | 2 | 1 2.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
Inflammation, Chronic Active, Diffuse| 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3| |
| 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Chronic, Diffuse | | 1 2.0|
Inflammation, Chronic Active, Diffuse| 1 | 1 1.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrous Osteodystrophy | 3 3 3 2 | 7 2.6|
Joint, Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage, Acute, Focal | | 1 2.0|
Hydrocephalus | | 1 2.0|
Inflammation, Acute, Focal | 2 | 1 2.0|
Mineralization, Multifocal | 3 2 3 2 1 2 2 3 2 2 2 3 2 1 1 3 2 | 29 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + M M + M + + M M + + + + + + + + + +| 40 |
Inflammation, Chronic | 2| 1 2.0|
Inflammation, Chronic Active | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Diffuse, | | |
Histiocyte | | 2 2.0|
Infiltration Cellular, Diffuse, | | |
Mixed Cell | | 1 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 3 1 | 9 1.9|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
Artery, Inflammation, Acute, | | |
Multifocal | 4 | 1 4.0|
Mediastinum, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 | 2 2.5|
Peribronchiolar, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3| |
| 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic Active, Multifocal | | 1 1.0|
Pleura, Inflammation, Chronic Active,| | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | | 1 2.0|
Mucosa, Inflammation, Chronic | | 1 1.0|
Mucosa, Inflammation, Chronic Active | 1 | 3 1.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 3 2.0|
Olfactory Epithelium, Atrophy, Focal | | 1 3.0|
Respiratory Epithelium, Hyperplasia | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy | 4 | 1 4.0|
Cornea, Neovascularization | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + + + + | 10 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 3 | 6 2.5|
Infiltration Cellular, Multifocal, | | |
Mixed Cell | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 2 2 1 1 1 2 3 2 2 1 2 1| 22 1.9|
Capsule, Inflammation, Chronic Active| | 2 2.5|
Medulla, Epithelium, Karyomegaly, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + M + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 7| 3| 3| |
| 2| 2| 2| 1| 2| 0| 5| 5| 4| 4| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 0| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 2 | 2 1.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 2 1 2 2 2 1 2 2 2 | 19 1.8|
Infiltration Cellular, Multifocal, | | |
Mixed Cell | 1 | 1 1.0|
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|
DAY ON TEST | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|
| 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + A M M + + A + + + + + + + + + M + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + M +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + M M M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + M M M +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + A + + + + + + A + + + + + + + M M M +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cytomegaly, Focal | |
Fatty Change, Diffuse | |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Hemorrhage, Multifocal | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Multifocal, Subacute | 1 1 1 3 1 |
Necrosis, Multifocal | 1 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Inflammation, Chronic Active | 3 |
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 3 2 1 2 2 3 2 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + M M M +|
Hyperplasia, Diffuse, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|
DAY ON TEST | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|
| 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active, Focal | 2 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cardiomyopathy | 1 |
Atrium Left, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Diffuse | 3 4 2 4 4 |
Capsule, Hyperplasia, Multifocal | 3 3 1 4 3 3 3 3 3 3 2 2 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Angiectasis, Multifocal | 3 |
Atrophy, Focal | 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Multifocal | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + M + M M M + M + + M + + M + M M M M|
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + M M + +|
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Cyst, Multifocal | |
__________________________________________________________________________|
Ovary | + M + + + + + + + M + + + + + + + + + M + + + M +|
Angiectasis | 1 |
Cyst | X |
Hyperplasia, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|
DAY ON TEST | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|
| 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + M + + M + +|
Dilatation | 4 4 3 |
Hyperplasia, Cystic | 2 2 2 1 1 1 1 1 1 1 1 2 1 2|
Inflammation, Chronic, Diffuse | 3 |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + M + + + + + + + + + M + + + + +|
Hypoplasia, Focal | 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Lymphoid | |
Bronchial, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + M + + M + + + + + + M + + + M +|
Hyperplasia, Lymphoid | 4 3 |
Hyperplasia, Re Cell | |
Pigmentation, Diffuse, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + I + + M + M + M + + M + M + M M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Depletion Lymphoid | 3 4 |
Developmental Malformation | |
Hyperplasia, Lymphoid | 3 2 |
Hyperplasia, Plasma Cell | |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + M + + + + M + + + + + + + M M M + + + + +|
Angiectasis, Multifocal | |
Cyst, Multiple | |
Depletion Lymphoid | 3 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + M + M + M +|
Ectasia, Multifocal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Diffuse| 1 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + M + + + + + + + + + M + + + + +|
Fibrous Osteodystrophy | 2 2 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|
DAY ON TEST | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|
| 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization, Multifocal | 2 1 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + M + + + + M + + + M + + + + + + + + M M +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Crystals | 4 |
Edema | |
Infiltration Cellular, Diffuse, | |
Histiocyte | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 3 2 3 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 1 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Inflammation, Chronic | |
Active, Focal | 2 |
Alveolus, Inflammation, Chronic | |
Active, Multifocal | |
Bronchiole, Inflammation, Chronic | |
Active, Focal | |
Bronchiole, Alveolus, Inflammation, | |
Chronic Active, Focal | |
Bronchiole, Alveolus, Inflammation, | |
Chronic Active, Multifocal | 3 1 1 1 2 2 1 2 2 2 2 2 1 2 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + I + + + + +|
Lumen, Crystals | |
Mucosa, Inflammation, Chronic Active | 3 1 3 3 2 2 4 2 2 3 4 3 2 2 2 3 2 3 3 1 3 3 4|
Nasolacrimal Duct, Hyperplasia | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Respiratory Epithelium, Hyperplasia | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M + + +|
Edema | |
Metaplasia, Multifocal, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 7| 6| 0| 7| 1| 1| 1| 7|
DAY ON TEST | 3| 6| 3| 3| 6| 3| 3| 3| 3| 0| 3| 3| 1| 3| 3| 3| 3| 2| 0| 4| 3| 4| 4| 4| 3|
| 5| 7| 5| 4| 4| 4| 3| 3| 3| 3| 3| 2| 6| 2| 1| 5| 5| 8| 3| 2| 4| 8| 8| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 |
Cortex, Regeneration, Multifocal | 2 |
Cortex, Epithelium, Hyperplasia, | |
Atypical, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + M + + + + + + + + + M + M M M +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1|
Infiltration Cellular, Multifocal, | |
Mixed Cell | |
Perforation | X |
Serosa, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + + + + + A + M + + + + + + + +| 42 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + M M + + + + + + + + + + + +| 43 |
Peyer's Patch, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + M M M + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + M + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + M M M + + + + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M + + + + + + M M M + + + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Clear Cell Focus | X | 1 |
Cytomegaly, Focal | 3 | 1 3.0|
Fatty Change, Diffuse | 2 | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 1.0|
Hemorrhage, Multifocal | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 1| 3 1.3|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Multifocal, Subacute | | 5 1.4|
Necrosis, Multifocal | | 1 1.0|
Vacuolization Cytoplasmic, Multifocal| 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 2 | 4 1.5|
Inflammation, Chronic Active | | 1 3.0|
Acinus, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 1 2 1 2 2 2 1 2 4 | 21 2.0|
Inflammation, Chronic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia, Diffuse, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
Inflammation, Chronic Active, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Cardiomyopathy | 2 | 2 1.5|
Atrium Left, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia, Diffuse | 3 3 3 3 3 2 2| 12 3.0|
Capsule, Hyperplasia, Multifocal | 3 3 3 4 2 3 3 2 2 1 4 3 3 3 2 3 | 32 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | X | 2 |
Angiectasis, Multifocal | | 1 3.0|
Atrophy, Focal | | 1 2.0|
Hyperplasia, Focal | 3 2 | 2 2.5|
Hypertrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Amyloid Deposition | | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Multifocal | 4 | 1 4.0|
Hyperplasia, Multifocal | 2 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M M M + + M M M M M + + M + + + + M + +| 25 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + A + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + M M + + + + + + + + M + +| 42 |
Follicle, Cyst | 3 | 2 3.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Cyst, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + +| 44 |
Angiectasis | | 1 1.0|
Cyst | X X X | 4 |
Hyperplasia, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + M + + + + + + + + + + + + +| 45 |
Dilatation | 4 3 4 3 4 4 4 4 4 | 12 3.8|
Hyperplasia, Cystic | 3 2 2 2 1 2 2 1 1 1 2 2 2 3 2| 29 1.6|
Inflammation, Chronic, Diffuse | | 1 3.0|
Metaplasia, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hypoplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bronchial, Hyperplasia, Lymphoid | 3 3 | 2 3.0|
Bronchial, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + +| 43 |
Hyperplasia, Lymphoid | 3 | 3 3.3|
Hyperplasia, Re Cell | 2 | 1 2.0|
Pigmentation, Diffuse, Hemosiderin | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M M M M + + + + + + + M + M| 32 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 3.0|
Depletion Lymphoid | | 2 3.5|
Developmental Malformation | X | 1 |
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + A + + + + + + + + + + + + + + + +| 42 |
Angiectasis, Multifocal | 3 | 1 3.0|
Cyst, Multiple | 2 | 1 2.0|
Depletion Lymphoid | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Ectopic Parathyroid Gland | X X | 2 |
Hyperplasia, Lymphoid | 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + +| 44 |
Ectasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + M + + + + + + + M + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active, Diffuse| | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrous Osteodystrophy | 3 2 2 2 2 | 8 2.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Mineralization, Multifocal | 1 2 1 2 1 1 1 1 1 | 16 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + + + + M M M + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Crystals | | 1 4.0|
Edema | 4 | 1 4.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | 4 | 2 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 3 2 | 7 2.4|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 | 4 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolus, Inflammation, Chronic | | |
Active, Focal | | 1 2.0|
Alveolus, Inflammation, Chronic | | |
Active, Multifocal | 1 | 1 1.0|
Bronchiole, Inflammation, Chronic | | |
Active, Focal | 1 | 1 1.0|
Bronchiole, Alveolus, Inflammation, | | |
Chronic Active, Focal | 1 | 1 1.0|
Bronchiole, Alveolus, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 1| 1| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 4| 4| 4| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 2| 1| 5| 4| 4| 0| 4| 4| 8| 8| 8| 2| 3| 3| 2| 2| 2| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic Active, Multifocal | 2 3 3 2 3 3 2 2 2 3 2 3 2 1 1 3 3 2 3| 35 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lumen, Crystals | 3 3 3 | 3 3.0|
Mucosa, Inflammation, Chronic Active | 3 4 3 3 2 2 3 2 2 2 3 3 2 2 2 2 3 2 3 3 3 2 1 3| 47 2.6|
Nasolacrimal Duct, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 3 | 2 2.5|
Respiratory Epithelium, Hyperplasia | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 47 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Edema | 3 | 1 3.0|
Metaplasia, Multifocal, Squamous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + + + | 5 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 2 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 4 1 1 2| 7 1.9|
Cortex, Regeneration, Multifocal | 1 | 2 1.5|
Cortex, Epithelium, Hyperplasia, | | |
Atypical, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + M M M + + + + + + + + + + +| 40 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 2 | 3 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 3 1 3 2 | 9 1.7|
Infiltration Cellular, Multifocal, | | |
Mixed Cell | 3 | 1 3.0|
Perforation | | 1 |
Serosa, Inflammation, Chronic | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|
| 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Gallbladder | |
Dilatation | |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + + + |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + +|
Angiectasis, Focal | |
Hematocyst | 4 |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Necrosis, Diffuse | 3 |
Portal, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | |
Fat, Necrosis, Multifocal | 4 4 |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Salivary Glands | M |
__________________________________________________________________________|
Stomach | + + |
__________________________________________________________________________|
Stomach, Forestomach | + + |
__________________________________________________________________________|
Stomach, Glandular | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
Capsule, Hyperplasia, Diffuse | |
Capsule, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | M |
__________________________________________________________________________|
Adrenal Gland, Medulla | M |
__________________________________________________________________________|
Islets, Pancreatic | + |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + |
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|
| 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + |
Abscess, Multiple | |
Cyst | 4 2 3 4 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hyperplasia, Cystic | 2 2 2 3 2 2 3 3 2 2 3 2 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4|
__________________________________________________________________________|
Thymus | + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Hemorrhage, | |
Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Fibrous Osteodystrophy | 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Mineralization, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Crystals | 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 1 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 6| 9| 3| 3| 3| 3| 7| 3| 8| 9| 3| 3| 3| 3| 0| 3| 1|
| 5| 4| 5| 5| 5| 4| 9| 3| 5| 3| 3| 2| 2| 2| 9| 5| 2| 0| 5| 4| 4| 3| 6| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active, Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Inflammation, Chronic | |
Active, Multifocal | |
Bronchiole, Hyperplasia, Focal | |
Bronchiole, Hyperplasia, Multifocal | 2 |
Bronchiole, Alveolus, Inflammation, | |
Chronic Active, Focal | 3 1 1 2 |
Bronchiole, Alveolus, Inflammation, | |
Chronic Active, Multifocal | 1 3 2 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Mucosa, Inflammation, Chronic Active | 3 2 2 2 2 2 1 3 2 3 2 2 1 2 2 2 2 3 3 3 2 4 1 3|
Respiratory Epithelium, Hyperplasia | 3 3 3 3 2 3 2 3 3 4 3 3 3 2 3 3 2 4 4 4 3 3 2 4|
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| |
| 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + | 6 |
Peyer's Patch, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 16 |
Angiectasis, Focal | 3 | 1 3.0|
Hematocyst | | 1 4.0|
Bile Duct, Hyperplasia, Multifocal | 4 | 1 4.0|
Centrilobular, Necrosis, Diffuse | | 1 3.0|
Portal, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis, Focal | 2 | 1 2.0|
Fat, Necrosis, Multifocal | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach | + | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 3 |
Capsule, Hyperplasia, Diffuse | 4 | 1 4.0|
Capsule, Hyperplasia, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 3 |
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| |
| 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + +| 14 |
Abscess, Multiple | 4 | 1 4.0|
Cyst | X 4 X 3 3| 9 3.3|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 37 |
Dilatation | 4 4 4 4| 5 4.0|
Hyperplasia, Cystic | 2 4 3 3 2 3 2 2 2 2 2 2 1 2| 29 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M | 6 |
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
Hemorrhage | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 13 |
Hematopoietic Cell Proliferation | 3 4 4 | 6 3.8|
__________________________________________________________________________|____________|
Thymus | + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 20 |
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Hemorrhage, | | |
Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 12 |
Fibrous Osteodystrophy | 3 1 1 3 2 2 2 3 | 10 1.9|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 9| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| |
| 6| 3| 2| 2| 1| 5| 5| 5| 5| 7| 4| 6| 3| 4| 3| 3| 3| 2| 2| 1| 5| 5| 5| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mineralization, Multifocal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Crystals | 4 4 4 | 4 3.5|
Infiltration Cellular, Focal, | | |
Histiocyte | 2 2 | 4 1.8|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 2 1 2 | 10 1.5|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 2 1 | 6 1.5|
Inflammation, Chronic Active, Focal | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Alveolus, Inflammation, Chronic | | |
Active, Multifocal | 3 | 1 3.0|
Bronchiole, Hyperplasia, Focal | 2 | 1 2.0|
Bronchiole, Hyperplasia, Multifocal | | 1 2.0|
Bronchiole, Alveolus, Inflammation, | | |
Chronic Active, Focal | 4 | 5 2.2|
Bronchiole, Alveolus, Inflammation, | | |
Chronic Active, Multifocal | 3 2 1 2 | 9 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Exudate | 3 | 2 2.5|
Mucosa, Inflammation, Chronic Active | 4 2 3 2 2 2 3 3 2 3 2 3 3 2 3 3 2 2 2 2 3 3 2 2 2| 49 2.4|
Respiratory Epithelium, Hyperplasia | 4 3 4 4 3 4 3 4 3 4 4 4 3 4 4 3 3 3 3 4 4 4 3 3 3| 49 3.3|
__________________________________________________________________________|____________|
Trachea | + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|
DAY ON TEST | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|
| 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Gallbladder | + + M + M + M + + + + + + + + + + + + M + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + M + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anisokaryosis | 3 |
Basophilic Focus | X X |
Cyst Multilocular | X 3 |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Infarct, Single | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 |
Inflammation, Acute, Multifocal | |
Karyomegaly, Multifocal | 2 |
Necrosis, Acute, Multifocal | 2 3 |
Necrosis, Multifocal, Subacute | 3 |
Syncytial Alteration, Multifocal | 2 |
Median Lobe, Congestion, Diffuse | 4 |
Median Lobe, Fibrosis | 3 |
Median Lobe, Thrombosis | 4 |
Median Lobe, Hepatocyte, Atrophy, | |
Diffuse | 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Acute, Focal | 3 |
Artery, Adventitia, Infiltration | |
Cellular, Focal, Mixed Cell | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Acinus, Atrophy, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|
DAY ON TEST | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|
| 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Hyperplasia, Focal | 3 |
Acinus, Hypertrophy, Multifocal | 2 |
Artery, Inflammation, Chronic Active,| |
Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 2 1 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Embolus, Single | |
Coronary Artery, Infiltration | |
Cellular, Focal, Mixed Cell | 3 |
Mitral Valve, Pigmentation, Focal, | |
Hemosiderin | 3 |
Myocardium, Inflammation, Chronic | |
Active, Multifocal | |
Perivascular, Inflammation, Acute, | |
Focal | |
Ventricle, Karyomegaly, Multifocal | 3 |
Ventricle Left, Bacterium | |
Ventricle Left, Inflammation, Focal, | |
Subacute | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | 1 1 3|
Capsule, Hyperplasia, Multifocal | 1 1 2 1 2 2 2 4 2 2 3 3 4 3 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia, Focal | 3 |
Hyperplasia, Multifocal | 3 |
Hypertrophy, Focal | 2 2 2 |
Hypertrophy, Multifocal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + M + + M + M + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|
DAY ON TEST | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|
| 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + M + +|
Pars Distalis, Cyst | 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Abscess | 3 3 |
Cyst | X X X X |
Cyst Multilocular | X |
Inflammation, Chronic | 3 3 2 |
Inflammation, Chronic Active | 3 4 3 4 4 |
__________________________________________________________________________|
Prostate | + M + + + M + + + + + + + + + + + + + + + + M + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Acute, Suppurative | |
Inflammation, Chronic Active | 4 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 2 3 |
Seminiferous Tubule, Degeneration, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Re Cell | |
Lumbar, Hemorrhage | 4 |
Lumbar, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + M + M + + +|
Hematopoietic Cell Proliferation | 4 2 3 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|
DAY ON TEST | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|
| 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 3 3 3 3 2 3 3 2 3 |
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 2 2 2 3 3 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Thymus | M + M + + + + M + + + + M + + + + + + + + + + M M|
Depletion Lymphoid | |
Syncytial Alteration | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M + + M M + M M M M + M M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Prepuce, Necrosis | 4 |
Prepuce, Ulcer | 4 4 |
Subcutaneous Tissue, Cyst | |
Subcutaneous Tissue, Inflammation, | |
Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Sternum, Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Mineralization, Focal | 1 |
Mineralization, Multifocal | 4 2 2 2 2 3 3 2 3 2 2 1 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Diffuse, | |
Histiocyte | 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2|
Interstitium, Inflammation, Acute, | |
Focal | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 2| 7| 6| 7|
DAY ON TEST | 7| 1| 8| 3| 6| 9| 7| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 0| 3| 6| 3| 5| 3|
| 3| 7| 7| 2| 7| 6| 0| 2| 2| 2| 5| 4| 9| 3| 3| 3| 3| 3| 2| 7| 2| 6| 1| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Acute | 2 1 |
Mucosa, Inflammation, Chronic | |
Mucosa, Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Respiratory Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Single | 3 |
Embolus, Multifocal | |
Hydronephrosis | 3 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 2 2 |
Infiltration Cellular, Multifocal, | |
Mixed Cell | 1 |
Inflammation, Acute, Multifocal, | |
Suppurative | |
Inflammation, Chronic Active, | |
Multifocal, Suppurative | 4 4 |
Mineralization, Focal | |
Cortex, Renal Tubule, Epithelium, | |
Hyperplasia, Atypical, Focal | 2 |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Embolus | |
Inflammation, Chronic Active, Diffuse| 4 |
Inflammation, Chronic Active, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3| |
| 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + M + + + + + + A M + A + +| 41 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + A + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + M + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Anisokaryosis | | 1 3.0|
Basophilic Focus | | 2 |
Cyst Multilocular | | 2 3.0|
Fatty Change, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 1 2.0|
Infarct, Single | | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | | 1 2.0|
Inflammation, Acute, Multifocal | 3 | 1 3.0|
Karyomegaly, Multifocal | | 1 2.0|
Necrosis, Acute, Multifocal | | 2 2.5|
Necrosis, Multifocal, Subacute | | 1 3.0|
Syncytial Alteration, Multifocal | | 1 2.0|
Median Lobe, Congestion, Diffuse | | 1 4.0|
Median Lobe, Fibrosis | | 1 3.0|
Median Lobe, Thrombosis | | 1 4.0|
Median Lobe, Hepatocyte, Atrophy, | | |
Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 | 2 2.5|
Inflammation, Acute, Focal | | 1 3.0|
Artery, Adventitia, Infiltration | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3| |
| 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cellular, Focal, Mixed Cell | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Acinus, Atrophy, Multifocal | | 1 2.0|
Acinus, Hyperplasia, Focal | | 1 3.0|
Acinus, Hypertrophy, Multifocal | | 1 2.0|
Artery, Inflammation, Chronic Active,| | |
Focal | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 1 3 2 2 2 1 2 2 2 1 2 1 2| 24 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + M + M + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal, Squamous | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Embolus, Single | 3 | 1 3.0|
Coronary Artery, Infiltration | | |
Cellular, Focal, Mixed Cell | | 1 3.0|
Mitral Valve, Pigmentation, Focal, | | |
Hemosiderin | | 1 3.0|
Myocardium, Inflammation, Chronic | | |
Active, Multifocal | 2 | 1 2.0|
Perivascular, Inflammation, Acute, | | |
Focal | 3 | 1 3.0|
Ventricle, Karyomegaly, Multifocal | | 1 3.0|
Ventricle Left, Bacterium | X | 1 |
Ventricle Left, Inflammation, Focal, | | |
Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Capsule, Hyperplasia, Focal | | 3 1.7|
Capsule, Hyperplasia, Multifocal | 2 1 1 2 2 1 3 2 1 2 2 3 1 3 3 3 2 2 2| 36 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3| |
| 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia, Focal | 2 3 2 4| 5 2.8|
Hyperplasia, Multifocal | 3 2 3 1 2 | 6 2.3|
Hypertrophy, Focal | 1 2 2 2| 7 1.9|
Hypertrophy, Multifocal | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Hyperplasia, Multifocal | 3 2 2 2 3 3 | 7 2.4|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M M M + M + + + + M M + M + + + + M + M +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + I + + + + + + + + + + M + + + + +| 45 |
Pars Distalis, Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ultimobranchial Cyst | X | 1 |
Follicular Cell, Hyperplasia | | 1 1.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 15 |
Abscess | 4 4 2 3 | 6 3.2|
Cyst | 4 | 5 4.0|
Cyst Multilocular | | 1 |
Inflammation, Chronic | | 3 2.7|
Inflammation, Chronic Active | 4 3 | 7 3.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Inflammation, Acute, Suppurative | 4 | 1 4.0|
Inflammation, Chronic Active | 3 | 3 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + M + +| 48 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3| |
| 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Atrophy | | 3 2.3|
Seminiferous Tubule, Degeneration, | | |
Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Myeloid Cell, Hyperplasia | 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Re Cell | 2 | 1 2.0|
Lumbar, Hemorrhage | | 1 4.0|
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
Hyperplasia, Re Cell | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + M + M + + + + + M + + M + +| 42 |
Hematopoietic Cell Proliferation | 2 3 3 | 6 2.8|
Hemorrhage | 2 2 2 1 2 3 4 4 2 3 2 2 3 3 3| 25 2.6|
Hyperplasia, Re Cell | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Depletion Lymphoid | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 4 2 3 2 | 11 2.7|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Re Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M M + + M + + + + M + + M M A + M + + +| 35 |
Depletion Lymphoid | 4 | 1 4.0|
Syncytial Alteration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M + M M M + M M M M M M + M M M M + M| 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Prepuce, Necrosis | 4 4 | 3 4.0|
Prepuce, Ulcer | | 2 4.0|
Subcutaneous Tissue, Cyst | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Granulomatous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3| |
| 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Sternum, Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 2.0|
Mineralization, Focal | | 1 1.0|
Mineralization, Multifocal | 1 2 2 2 2 2 4 1 2 4 3 3 | 26 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M + + + + + + + + + + + + + + M + + + M + + M + M| 44 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Diffuse, | | |
Histiocyte | | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 1 1| 5 1.2|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 4 | 2 3.0|
Interstitium, Inflammation, Acute, | | |
Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Inflammation, Acute | 1 | 3 1.3|
Mucosa, Inflammation, Chronic | 1 | 1 1.0|
Mucosa, Inflammation, Chronic Active | 1 | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Cyst, Single | | 1 3.0|
Embolus, Multifocal | 3 | 1 3.0|
Hydronephrosis | 2 | 3 2.7|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 1| 3| 3| 3| 3| 4| 3| 8| 1| 3| 3| |
| 5| 4| 4| 3| 3| 4| 3| 3| 2| 2| 2| 2| 7| 1| 4| 5| 5| 4| 4| 8| 3| 8| 4| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 1 1 1 | 9 1.4|
Infiltration Cellular, Multifocal, | | |
Mixed Cell | | 1 1.0|
Inflammation, Acute, Multifocal, | | |
Suppurative | 4 | 1 4.0|
Inflammation, Chronic Active, | | |
Multifocal, Suppurative | | 2 4.0|
Mineralization, Focal | 1 | 1 1.0|
Cortex, Renal Tubule, Epithelium, | | |
Hyperplasia, Atypical, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Calculus Micro Observation Only | X | 2 |
Embolus | 4 | 1 4.0|
Inflammation, Chronic Active, Diffuse| | 1 4.0|
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + M + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M M + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | 3 |
Mucosa, Necrosis, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + M M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | M + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Basophilic Focus, Multiple | X |
Cyst Multilocular | |
Cytomegaly, Focal | 2 |
Degeneration, Ballooning, Multifocal | 1 |
Fatty Change, Focal | |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | X |
Necrosis, Acute, Focal | 4 |
Necrosis, Acute, Multifocal | |
Syncytial Alteration, Focal | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Fat, Inflammation, Chronic Active, | |
Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 |
Acinus, Hypertrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 3 3 2 2 3 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
Inflammation, Chronic Active, | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | 2 2 |
Capsule, Hyperplasia, Multifocal | 2 3 3 2 4 4 3 3 3 3 3 2 3 2 2 3 2 4 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia, Focal | 3 2 2 |
Hyperplasia, Multifocal | 3 1 2|
Hypertrophy, Focal | 2 4 4 1 |
Hypertrophy, Multifocal | 4 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Parathyroid Gland | + + M M M M + + + M + + + + + + + + + + M + M + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Inflammation, Chronic, Focal | |
Ultimobranchial Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + |
Cyst | 3 2 3 |
__________________________________________________________________________|
Prostate | M M + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Left, Hemorrhage | |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + M + + + + + + + + M + + + + + + M + + +|
Hyperplasia, Lymphoid | 2 2|
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M M M + + + + + + + + + + + + M M + + + M +|
Hemorrhage | 3 4 3 2 2 3 3 2 3|
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Re Cell | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Diffuse, Lymphoid | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Thrombosis | |
Lymphocyte, Necrosis, Multifocal | |
__________________________________________________________________________|
Thymus | + + + + M + + M + + + + + + + + M + M + + M + +|
Cyst, Multiple | |
Depletion Lymphoid | |
Hyperplasia, Diffuse, Lymphoid | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + + M M M M M M M + + + + + + + M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoporosis, Focal | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 1 2 1 2 3 2 1 1 2 2|
Artery, Meninges, Inflammation, | |
Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + M M + + + + + + + + + + + + + + + + + + M + +|
Inflammation, Acute, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic, Multifocal | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Granuloma | |
Infiltration Cellular, Focal, | |
Histiocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 |
Alveolus, Inflammation, Chronic | |
Active, Focal | 2 |
Alveolus, Inflammation, Chronic | |
Active, Multifocal | 1 2 1 |
Bronchiole, Alveolus, Inflammation, | |
Chronic Active, Focal | |
Bronchiole, Alveolus, Inflammation, | |
Chronic Active, Multifocal | 2 3 2 2 2 2 1 2 2 4 2 1 1 3 2 2 |
Mediastinum, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
Pleura, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Acute | 1 |
Mucosa, Inflammation, Chronic Active | 2 2 3 3 3 3 3 3 2 3 2 4 2 3 3 2 3 4 3 3 2 2 3 2|
Respiratory Epithelium, Hyperplasia | 3 3 4 4 4 4 4 3 4 3 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Glands, Hyperplasia, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Left, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Chronic, Focal, Two | 4 |
Degeneration, Chronic, Multifocal | 4 |
Hydronephrosis | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 7| 7| 1| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 8| 8| 2| 2| 2| 2| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 3| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
25 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Nephropathy, Chronic | 2 1 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Urinary Bladder | + M + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + M + + M M A M + + + + + + + M + + + M M + M A +| 37 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M M + + + + + + + + + + + + + + + + +| 44 |
Hyperplasia, Focal, Lymphoid | | 1 3.0|
Mucosa, Necrosis, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + M + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + M + + + + + + + + M + + + + + M + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + M + + + + + + + + M + + + A + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + M + + + + + + + + +| 48 |
Angiectasis, Multifocal | 3 | 1 3.0|
Basophilic Focus, Multiple | | 1 |
Cyst Multilocular | 4 | 1 4.0|
Cytomegaly, Focal | | 1 2.0|
Degeneration, Ballooning, Multifocal | | 1 1.0|
Fatty Change, Focal | 2 | 1 2.0|
Fibrosis, Focal | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Necrosis, Acute, Focal | | 1 4.0|
Necrosis, Acute, Multifocal | 3 4 | 2 3.5|
Syncytial Alteration, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Fat, Inflammation, Chronic Active, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 2 2.0|
Acinus, Hypertrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 1 1 1 2 1 2 2 2 2 2 1| 24 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Epithelium, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + M + + + + + +| 48 |
Capsule, Hyperplasia, Focal | | 2 2.0|
Capsule, Hyperplasia, Multifocal | 3 2 2 2 2 2 2 4 2 2 2 2 2 2 1 2 2 2 2 3| 39 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | X X | 3 |
Hyperplasia, Focal | 2 1 2 2 | 7 2.0|
Hyperplasia, Multifocal | 2 3 | 5 2.2|
Hypertrophy, Focal | 2 2 2 2 | 8 2.4|
Hypertrophy, Multifocal | | 3 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 3 | 2 3.0|
Hyperplasia, Multifocal | 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + M + M + + + + M + M M + + + + + M + +| 35 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + I +| 47 |
Pars Distalis, Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + M + + + + + + + + +| 47 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Ultimobranchial Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 8 |
Cyst | 4 2 X X 4 | 8 3.0|
__________________________________________________________________________|____________|
Prostate | + + + M + + M + + + + + + + + M + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Left, Hemorrhage | 4 | 1 4.0|
Seminiferous Tubule, Atrophy | 3 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + M + M M M + M + + + M + M M + + + M + + +| 35 |
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Re Cell | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M M M M M + + + + + + + + M M M + + + + + + M| 33 |
Hemorrhage | 2 2 4 2 3 | 14 2.7|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Re Cell | 2 | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Multifocal | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hyperplasia, Diffuse, Lymphoid | 4 | 1 4.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Thrombosis | 3 | 1 3.0|
Lymphocyte, Necrosis, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + M M M + + I + + + M + + M M + + M + M| 34 |
Cyst, Multiple | 2 | 1 2.0|
Depletion Lymphoid | 2 | 1 2.0|
Hyperplasia, Diffuse, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M + + M M M M + M M + M + M + + M + + M M M| 21 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteoporosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | 2 1 2 2 2 1 1 1 2 2 | 21 1.7|
Artery, Meninges, Inflammation, | | |
Chronic, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Acute, Diffuse | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Congestion | 2 | 1 2.0|
Granuloma | 4 | 1 4.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 3 | 3 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | | 1 2.0|
Alveolus, Inflammation, Chronic | | |
Active, Focal | | 1 2.0|
Alveolus, Inflammation, Chronic | | |
Active, Multifocal | | 3 1.3|
Bronchiole, Alveolus, Inflammation, | | |
Chronic Active, Focal | 3 | 1 3.0|
Bronchiole, Alveolus, Inflammation, | | |
Chronic Active, Multifocal | 2 2 3 2 2 4 2 4 4 3 2 2 3| 29 2.3|
Mediastinum, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 2 | 2 2.0|
Pleura, Hyperplasia, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 0| 0| 3| 3| 3| 6| 3| |
| 5| 5| 5| 5| 5| 6| 2| 5| 4| 4| 3| 3| 3| 3| 3| 4| 3| 5| 3| 2| 5| 5| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
25 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Acute | | 1 1.0|
Mucosa, Inflammation, Chronic Active | 2 3 3 3 4 3 2 4 4 4 3 2 3 3 3 2 3 3 2 4 4 4 1 4| 48 2.9|
Respiratory Epithelium, Hyperplasia | 4 4 4 4 4 4 3 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| 49 3.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + M + + + + + + + + M + + + + + + + + +| 48 |
Inflammation, Chronic, Focal | | 1 1.0|
Glands, Hyperplasia, Diffuse | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Left, Inflammation, Chronic | | |
Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Degeneration, Chronic, Focal, Two | | 1 4.0|
Degeneration, Chronic, Multifocal | | 1 4.0|
Hydronephrosis | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 | 3 1.3|
Nephropathy, Chronic | 2 | 3 1.7|
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Gallbladder | + + + + + + M |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Necrosis, Acute, Focal | 1 |
Necrosis, Acute, Multifocal | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + A |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Cardiomyopathy | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
Capsule, Hyperplasia, Multifocal | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Parathyroid Gland | M M M + + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Chronic Active, | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
Multifocal | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | |
Cyst | |
Dilatation | 3 |
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Prostate | M + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + M + + +|
Dilatation | 3|
__________________________________________________________________________|
Testes | + + + + + + + |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + M + |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + M + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 4 4 2 2 2 3 2 2|
Hyperplasia, Lymphoid | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + A +|
Hematopoietic Cell Proliferation | 4 3 3 |
__________________________________________________________________________|
Thymus | + + M M + M M |
Depletion Lymphoid | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Ulcer | |
Prepuce, Abscess | 4 |
Prepuce, Inflammation, Chronic Active| |
Prepuce, Ulcer | 4 |
Scrotal, Pigmentation, Focal, Melanin| 4 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Scrotal, Hair Follicle, Hyperplasia, | |
Focal | 2 |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + M + |
__________________________________________________________________________|
Skeletal Muscle | |
Arteriole, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Mineralization, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + M M M |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Focal, | |
Histiocyte | 1|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Inflammation, Chronic | |
Active, Focal | |
Bronchiole, Hyperplasia, Focal | |
Bronchiole, Hyperplasia, Multifocal | 2 1 1 |
Bronchiole, Inflammation, Chronic, | |
Focal | 1 |
Bronchiole, Alveolus, Inflammation, | |
Chronic, Multifocal | 1 |
Bronchiole, Alveolus, Inflammation, | |
Chronic Active, Focal | 2 |
Bronchiole, Alveolus, Inflammation, | |
Chronic Active, Multifocal | 3 3 3 3 3 3 |
Mediastinum, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
Pleura, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 3| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 6| 3| 5| 3| 2| 3| 7| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
| 3| 2| 7| 1| 3| 1| 4| 2| 4| 6| 5| 5| 5| 5| 8| 4| 4| 4| 3| 3| 2| 2| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Chronic Active | 2 3 1 2 1 2 1 2 1 1 2 1 1 2 1 2 2 2 1 2 3 1 4 2|
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Respiratory Epithelium, Hyperplasia | 4 4 3 4 3 4 3 3 3 3 3 2 3 3 3 3 2 3 2 3 3 3 3 3|
__________________________________________________________________________|
Trachea | + + + + + M + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Inflammation, Acute, Focal | |
Inflammation, Chronic Active, | |
Multifocal, Suppurative | |
Mineralization, Multifocal | 2 |
Nephropathy, Chronic | 1 |
Capsule, Fibrosis, Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
Inflammation, Chronic Active, Diffuse| |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3| |
| 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + | 9 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + A A + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A M + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + M | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + M + + | 10 |
__________________________________________________________________________|____________|
Liver | A + + + + + + + + + + + | 23 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 1 2.0|
Necrosis, Acute, Focal | 2 1 | 3 1.3|
Necrosis, Acute, Multifocal | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + A + + | 9 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 11 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + A + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + A + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + A + + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 13 |
Cardiomyopathy | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + | 10 |
Capsule, Hyperplasia, Multifocal | 1 | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + | 10 |
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + | 9 |
Hyperplasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | A + M + + | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3| |
| 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | A + M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Inflammation, Chronic Active, | | |
Multifocal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | A + + + + | 11 |
__________________________________________________________________________|____________|
Preputial Gland | + A + + | 6 |
Abscess | 4 | 1 4.0|
Cyst | 4 | 1 4.0|
Dilatation | | 1 3.0|
Inflammation, Chronic | 1 | 3 1.7|
__________________________________________________________________________|____________|
Prostate | + A + + | 9 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 17 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | A + + + + +| 12 |
Seminiferous Tubule, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 10 |
Myeloid Cell, Hyperplasia | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 26 |
Angiectasis, Focal | 2 | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + | 19 |
Hematopoietic Cell Proliferation | 1 2 1 | 4 1.5|
Hemorrhage | 2 2 4 2 | 12 2.6|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + A + + + | 14 |
Hematopoietic Cell Proliferation | 4 3 4 | 6 3.5|
__________________________________________________________________________|____________|
Thymus | M A + + + | 6 |
Depletion Lymphoid | 3 | 1 3.0|
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3| |
| 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M | 2 |
__________________________________________________________________________|____________|
Skin | A + + + + + + + + + + + + +| 30 |
Inflammation, Chronic Active | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
Prepuce, Abscess | 4 | 2 4.0|
Prepuce, Inflammation, Chronic Active| 3 | 1 3.0|
Prepuce, Ulcer | 4 | 2 4.0|
Scrotal, Pigmentation, Focal, Melanin| | 1 4.0|
Scrotal, Hair Follicle, Hyperplasia, | | |
Focal | | 1 2.0|
Subcutaneous Tissue, Abscess | 4 | 1 4.0|
Subcutaneous Tissue, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Arteriole, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 11 |
Mineralization, Multifocal | 2 2 2 2 | 5 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 6 |
__________________________________________________________________________|____________|
Lung | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 1 3.0|
Infiltration Cellular, Focal, | | |
Histiocyte | 1 | 2 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 1 | 3 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1| 2 1.5|
Alveolus, Inflammation, Chronic | | |
Active, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05070-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:49:27
__________________________________________________________________________________________________________________________________
| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 3| 3| 9| 5| 8| 3| 6| 3| 3| 3| 8| 3| |
| 2| 3| 5| 5| 4| 6| 4| 3| 3| 3| 3| 2| 2| 2| 2| 5| 0| 2| 5| 1| 4| 3| 3| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchiole, Hyperplasia, Focal | 1 | 1 1.0|
Bronchiole, Hyperplasia, Multifocal | 1 | 4 1.3|
Bronchiole, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Bronchiole, Alveolus, Inflammation, | | |
Chronic, Multifocal | | 1 1.0|
Bronchiole, Alveolus, Inflammation, | | |
Chronic Active, Focal | 2 1 | 3 1.7|
Bronchiole, Alveolus, Inflammation, | | |
Chronic Active, Multifocal | 2 3 3 2 4 1 | 12 2.8|
Mediastinum, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 | 1 2.0|
Pleura, Infiltration Cellular, | | |
Lymphocyte | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mucosa, Inflammation, Chronic Active | 1 2 2 3 2 3 3 3 2 2 1 2 3 2 1 1 3 2 3 3 4 1 2| 47 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 3 3 3 4 3 3 4 3 4 3 3 3 4 3 4 3 3 3 3 4 4 4 3 3| 48 3.2|
__________________________________________________________________________|____________|
Trachea | A + M + + | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + A + + | 11 |
Inflammation, Acute, Focal | 1 | 1 1.0|
Inflammation, Chronic Active, | | |
Multifocal, Suppurative | 4 | 1 4.0|
Mineralization, Multifocal | | 1 2.0|
Nephropathy, Chronic | | 1 1.0|
Capsule, Fibrosis, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + | 27 |
Inflammation, Chronic Active, Diffuse| 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 563339-563339/563339
--multipart-boundary--