TDMS Study 05070-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Midwest Research Inst DATE: 09/09/94
EXP: 05070 VINYL TOLUENE TIME: 00:18:12
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 56406
CONT: N01-ES-38042 CAS: 25013154
PATHOLOGIST: M. STEDHAM
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Midwest Research Inst DATE: 09/09/94
EXP: 05070 VINYL TOLUENE TIME: 00:18:12
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 56406
CONT: N01-ES-38042 CAS: 25013154
PATHOLOGIST: M. STEDHAM
VINYL TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 514 529 567 588 607 644 648 658 670 673 |
| 673 687 696 707 714 717 |
| CENSORED DEATHS |
| 266 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 358 392 434 550 553 567 574 582 602 623 |
| 623 632 661 676 676 682 686 695 714 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 3 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 574 664 683 702 703 716 |
| CENSORED DEATHS |
| 148 148 252 |
| |
==================================================================================
VINYL TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 95.9 91.8 83.7 67.3 |
| | |
| | |
|10 PPM | 100.0 100.0 100.0 98.0 96.0 94.0 94.0 82.0 74.0 60.0 |
| | |
| | |
|25 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 97.9 95.7 87.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 PPM 25 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 67.3% 60.0% 87.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.026N P=0.472 P=0.031N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 643.3 600.2 673.7 |
|NATURAL DEATHS (C) | (16.1) (23.2) (21.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.6 678.7 691.2 |
|(STANDARD ERROR) | (11.6) (12.9) (18.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
VINYL TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 47 469 560 574 589 672 692 692 700 705 |
| 709 714 715 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 1 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 459 582 657 665 679 679 690 693 696 696 |
| 714 714 |
| CENSORED DEATHS |
| 606 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 8 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 350 464 603 616 667 672 674 728 |
| CENSORED DEATHS |
| 3 42 148 148 148 148 148 148 |
| |
==================================================================================
VINYL TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 98.0 98.0 98.0 96.0 96.0 90.0 90.0 72.0 |
| | |
| | |
|10 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 96.0 91.9 75.6 |
| | |
| | |
|25 PPM | 100.0 100.0 100.0 97.6 97.6 95.2 95.2 92.9 90.5 81.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 PPM 25 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 72.0% 75.6% 81.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.434N P=0.847N P=0.473N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 611.9 660.3 596.8 |
|NATURAL DEATHS (C) | (48.1) (20.9) (44.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 697.6 711.5 611.2 |
|(STANDARD ERROR) | (15.2) ( 6.8) (32.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
VINYL TOLUENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 PPM = 2
25 PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
|
| 2 2 1 1 3 3
| 2 2 1 1 3 3
95 +
| 2 2 1 1 3 3
|
| 1 1
P 90 + 2 2 1 1
E | 3 3
R | 22 11 3 3
C | 2 2 11
E 85 +
N | 2 2 1 1
T | 2 2
| 11
S 80 +
U |
R | 2 2 1 1
V | 2 2
I 75 + 11
V | 2 2 11
A |
L | 11
70 + 22 11
|
| 1 1
| 2 2
65 +
| 2 2
| 2 2
|
60 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 2 obs hidden.
VINYL TOLUENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 PPM = 2
25 PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
|
| 1 3 21 2
| 1 1 2 2
P 95 + 3 3
E | 1 1 2 2
R | 1 1 33 2 2
C |
E 90 + 1 3 1
N |
T | 12 1
| 33
S 85 +
U | 3 11 3
R | 11
V | 3 3
I 80 + 211
V |
A |
L | 11
75 + 2 2
| 11
| 1 1
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
--multipart-boundary
Content-type: text/plain
Range: bytes 24414-24414/24414
--multipart-boundary--