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https://ntp.niehs.nih.gov/go/1629

TDMS Study 05070-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           VINYL TOLUENE


NTP Experiment-Test: 05070-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03




       Facility:  Midwest Research Institute

       Chemical CAS #:  25013154

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           21           18                                                  
    Natural Death                                      3            1            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           28           26                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (5)          (46)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Parasite Metazoan                                2 (4%)                    8 (17%)                                            
      Artery, Inflammation, Chronic, Focal             1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (10)         (49)                                                
      Parasite Metazoan                                7 (14%)      1 (10%)      9 (18%)                                            
      Muscularis, Atrophy, Focal                       1 (2%)                                                                       
   Intestine Large, Rectum                            (46)         (9)          (46)                                                
      Parasite Metazoan                                2 (4%)                    3 (7%)                                             
      Mucosa, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)                                                                       
   Intestine Small, Duodenum                          (50)         (9)          (50)                                                
      Muscularis, Fibrosis, Focal                                                1 (2%)                                             
   Intestine Small, Ileum                             (48)         (7)          (48)                                                
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
      Parasite Metazoan                                                          1 (2%)                                             
   Liver                                              (50)         (33)         (50)                                                
      Angiectasis, Focal                               3 (6%)                    3 (6%)                                             
      Angiectasis, Multifocal                                       2 (6%)       1 (2%)                                             
      Basophilic Focus                                 8 (16%)      3 (9%)       7 (14%)                                            
      Basophilic Focus, Multiple                      19 (38%)      9 (27%)     14 (28%)                                            
      Clear Cell Focus                                 1 (2%)                                                                       
      Congestion, Acute, Multifocal                                 3 (9%)                                                          
      Cytomegaly, Multifocal                           1 (2%)                    1 (2%)                                             
      Cytoplasmic Alteration, Focal                    1 (2%)                    1 (2%)                                             
      Eosinophilic Focus                               1 (2%)                                                                       
      Fatty Change, Diffuse                            3 (6%)       1 (3%)                                                          
      Fatty Change, Focal                                                        2 (4%)                                             
      Fatty Change, Multifocal                         7 (14%)      1 (3%)       4 (8%)                                             
      Fibrosis, Multifocal                             1 (2%)                                                                       
      Granuloma, Multifocal                           19 (38%)      6 (18%)     14 (28%)                                            
      Hemorrhage, Acute, Multifocal                                              1 (2%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)       5 (15%)      6 (12%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatodiaphragmatic Nodule, Multiple             1 (2%)       1 (3%)                                                          
      Hyperplasia, Focal, Nodular                                   2 (6%)                                                          
      Hyperplasia, Multifocal, Nodular                 1 (2%)                    2 (4%)                                             
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
      Mitotic Alteration                                            1 (3%)       1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)                    3 (6%)                                             
      Mixed Cell Focus, Two                                                      1 (2%)                                             
      Necrosis, Focal                                  1 (2%)       1 (3%)                                                          
      Necrosis, Multifocal                             8 (16%)      1 (3%)       5 (10%)                                            
      Pigmentation, Multifocal                                      1 (3%)                                                          
      Bile Duct, Hyperplasia, Focal                    1 (2%)                                                                       
      Bile Duct, Hyperplasia, Multifocal               6 (12%)      7 (21%)      6 (12%)                                            
      Centrilobular, Atrophy, Multifocal               1 (2%)       1 (3%)                                                          
      Centrilobular, Degeneration, Diffuse             1 (2%)       4 (12%)                                                         
      Centrilobular, Degeneration, Multifocal                       1 (3%)                                                          
      Centrilobular, Fatty Change, Diffuse             4 (8%)       3 (9%)       5 (10%)                                            
      Centrilobular, Fatty Change, Multifocal                                    1 (2%)                                             
      Centrilobular, Necrosis, Diffuse                                           1 (2%)                                             
      Centrilobular, Necrosis, Multifocal              1 (2%)                    3 (6%)                                             
      Periportal, Fatty Change, Multifocal                          2 (6%)                                                          
      Portal, Inflammation, Chronic, Multifocal                                  1 (2%)                                             
   Mesentery                                          (4)          (2)          (5)                                                 
      Artery, Inflammation, Multifocal, Necrotizing                              1 (20%)                                            
      Fat, Inflammation, Focal, Necrotizing                                      1 (20%)                                            
      Fat, Necrosis, Focal                             1 (25%)                   4 (80%)                                            
   Pancreas                                           (50)         (13)         (49)                                                
      Inflammation, Focal, Granulomatous                                         1 (2%)                                             
      Acinus, Atrophy, Diffuse                         2 (4%)                                                                       
      Acinus, Atrophy, Focal                           1 (2%)                    2 (4%)                                             
      Acinus, Atrophy, Multifocal                     13 (26%)      3 (23%)      8 (16%)                                            
      Acinus, Hyperplasia, Focal                       1 (2%)                                                                       
      Artery, Inflammation, Chronic, Focal             2 (4%)                                                                       
      Artery, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)                                                                       
      Duct, Cyst, Multiple                                                       1 (2%)                                             
      Interlobular, Inflammation, Chronic, Diffuse     1 (2%)                                                                       
   Pharynx                                                                      (1)                                                 
      Mucosa, Palate, Inflammation, Chronic,                                                                                        
          Diffuse                                                                1 (100%)                                           
   Salivary Glands                                    (50)         (9)          (47)                                                
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
      Duct, Inflammation, Chronic Active, Focal        1 (2%)                                                                       
      Parotid Gland, Inflammation, Chronic Active,                                                                                  
           Focal                                                                 1 (2%)                                             
   Stomach, Forestomach                               (49)         (11)         (49)                                                
      Inflammation, Chronic Active                     3 (6%)       1 (9%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer, Single, Subacute                          1 (2%)                                                                       
      Epithelium, Hyperplasia                          2 (4%)       1 (9%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (11)         (50)                                                
      Cyst Epithelial Inclusion                                     1 (9%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mucosa, Cyst, Multiple                           2 (4%)                                                                       
   Tooth                                                                        (1)                                                 
      Peridontal Tissue, Inflammation, Chronic,                                                                                     
           Diffuse                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)                                                
      Abscess, Single                                  1 (2%)                                                                       
      Cardiomyopathy                                  36 (72%)      4 (40%)     40 (80%)                                            
      Artery, Inflammation, Chronic Active, Focal                                1 (2%)                                             
      Artery, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)                                                                       
      Atrium Left, Thrombosis                          2 (4%)       1 (10%)      2 (4%)                                             
      Epicardium, Inflammation, Chronic Active,                                                                                     
           Focal                                                                 1 (2%)                                             
      Myocardium, Degeneration, Focal                                            1 (2%)                                             
      Valve, Degeneration, Mucoid, Multifocal          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (14)         (50)                                                
      Bilateral, Capsule, Fibrosis, Multifocal                                   1 (2%)                                             
      Capsule, Accessory Adrenal Cortical Nodule       5 (10%)      1 (7%)       5 (10%)                                            
   Adrenal Gland, Cortex                              (50)         (14)         (50)                                                
      Angiectasis, Focal                               2 (4%)                                                                       
      Angiectasis, Multifocal                          4 (8%)       3 (21%)      4 (8%)                                             
      Atrophy                                                                    1 (2%)                                             
      Congestion                                       4 (8%)       1 (7%)       2 (4%)                                             
      Degeneration, Diffuse, Fatty                     1 (2%)                    1 (2%)                                             
      Degeneration, Fatty, Focal                       8 (16%)      1 (7%)       8 (16%)                                            
      Degeneration, Fatty, Multifocal                  2 (4%)       1 (7%)       1 (2%)                                             
      Hyperplasia, Focal                               9 (18%)                   2 (4%)                                             
      Hyperplasia, Multifocal                                       1 (7%)       1 (2%)                                             
      Hypertrophy, Focal                               4 (8%)                    1 (2%)                                             
      Hypertrophy, Multifocal                          2 (4%)       1 (7%)       1 (2%)                                             
      Pigmentation, Diffuse, Hemosiderin               2 (4%)                    1 (2%)                                             
      Pigmentation, Hemosiderin, Multifocal                                      1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (14)         (45)                                                
      Angiectasis, Multifocal                          1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Focal                               5 (10%)      1 (7%)       5 (11%)                                            
      Hyperplasia, Multifocal                          2 (4%)                    3 (7%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (12)         (49)                                                
      Ectopic Tissue, Focal                            1 (2%)                                                                       
      Hyperplasia, Focal                                                         4 (8%)                                             
      Hyperplasia, Multifocal                          2 (4%)                                                                       
      Hypertrophy, Focal                               2 (4%)                    1 (2%)                                             
      Hypoplasia, Diffuse                              1 (2%)                                                                       
   Pituitary Gland                                    (50)         (43)         (50)                                                
      Pars Distalis, Angiectasis, Focal                4 (8%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Angiectasis, Multifocal           2 (4%)       3 (7%)                                                          
      Pars Distalis, Concretion                                                  1 (2%)                                             
      Pars Distalis, Cyst                              5 (10%)     10 (23%)     10 (20%)                                            
      Pars Distalis, Cyst, Multiple                                 1 (2%)                                                          
      Pars Distalis, Hemorrhage, Chronic, Focal        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       1 (2%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                3 (6%)       2 (5%)       2 (4%)                                             
      Pars Distalis, Hyperplasia, Multifocal                        1 (2%)       1 (2%)                                             
      Pars Distalis, Pigmentation, Diffuse,                                                                                         
          Hemosiderin                                  1 (2%)                                                                       
      Pars Intermedia, Pigmentation, Diffuse,                                                                                       
          Hemosiderin                                  1 (2%)                                                                       
      Pars Nervosa, Pigmentation, Diffuse                                        1 (2%)                                             
   Thyroid Gland                                      (50)         (10)         (50)                                                
      Cyst                                             2 (4%)                    1 (2%)                                             
      Developmental Malformation                                    1 (10%)                                                         
      C-Cell, Hyperplasia, Focal                       2 (4%)                    3 (6%)                                             
      C-Cell, Hyperplasia, Multifocal                 21 (42%)      1 (10%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Necrosis, Acute                                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (11)         (46)                                                
      Abscess                                                       1 (9%)                                                          
      Atrophy                                                       1 (9%)       1 (2%)                                             
      Ectasia                                                       2 (18%)      4 (9%)                                             
      Hyperplasia                                      3 (6%)       1 (9%)       3 (7%)                                             
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (9%)       2 (4%)                                             
      Inflammation, Granulomatous                      2 (4%)                    3 (7%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Ovary                                              (50)         (18)         (50)                                                
      Angiectasis, Multifocal                          1 (2%)                                                                       
      Congestion, Diffuse                              1 (2%)                    1 (2%)                                             
      Cyst                                                          5 (28%)      3 (6%)                                             
      Hyperplasia                                      1 (2%)                                                                       
   Uterus                                             (50)         (18)         (50)                                                
      Adenomyosis, Focal                                                         1 (2%)                                             
      Cyst                                             1 (2%)                    1 (2%)                                             
      Dilatation                                       1 (2%)       3 (17%)      2 (4%)                                             
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Endometrium, Hyperplasia, Focal                  1 (2%)                                                                       
      Epithelium, Hyperplasia, Diffuse                 1 (2%)                    1 (2%)                                             
      Epithelium, Hyperplasia, Focal                   2 (4%)                    1 (2%)                                             
      Lumen, Hemorrhage                                             1 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (9)          (50)                                                
      Hyperplasia                                      2 (4%)                    3 (6%)                                             
      Hyperplasia, Megakaryocyte                                                 1 (2%)                                             
      Metaplasia, Diffuse, Osseous                     1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                        6 (12%)                   2 (4%)                                             
   Lymph Node                                         (50)         (17)         (50)                                                
      Hyperplasia, Re Cell                             1 (2%)                                                                       
      Mediastinal, Hemorrhage                          4 (8%)                    3 (6%)                                             
      Mediastinal, Hyperplasia, Re Cell                                          1 (2%)                                             
      Mediastinal, Pigmentation, Diffuse,                                                                                           
          Hemosiderin                                                            1 (2%)                                             
      Pancreatic, Hemorrhage                           1 (2%)       1 (6%)                                                          
      Pancreatic, Inflammation, Acute                               1 (6%)                                                          
      Pancreatic, Pigmentation, Hemosiderin                                      1 (2%)                                             
      Renal, Hyperplasia, Plasma Cell                                            1 (2%)                                             
      Renal, Hyperplasia, Re Cell                                                1 (2%)                                             
   Lymph Node, Mandibular                             (47)         (11)         (47)                                                
      Edema                                                                      1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Plasma Cell                         2 (4%)                    5 (11%)                                            
      Hyperplasia, Re Cell                                          1 (9%)       1 (2%)                                             
      Artery, Inflammation, Chronic Active, Focal                                1 (2%)                                             
   Lymph Node, Mesenteric                             (47)         (12)         (46)                                                
      Hemorrhage                                       3 (6%)       3 (25%)      2 (4%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Hyperplasia, Re Cell                             4 (9%)                    3 (7%)                                             
      Pigmentation, Hemosiderin                                     1 (8%)                                                          
   Spleen                                             (50)         (19)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Fibrosis, Focal                                               1 (5%)       2 (4%)                                             
      Fibrosis, Multifocal                                                       1 (2%)                                             
      Granuloma, Multifocal                            1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 5 (10%)                   5 (10%)                                            
      Hyperplasia, Multifocal, Reticulum Cell          1 (2%)                                                                       
      Metaplasia, Focal, Osseous                                    1 (5%)                                                          
      Pigmentation, Hemosiderin                       11 (22%)      1 (5%)      15 (30%)                                            
      Capsule, Ectopic Tissue                          1 (2%)                                                                       
      Capsule, Infiltration Cellular, Multifocal,                                                                                   
           Lymphocyte                                  1 (2%)                                                                       
   Thymus                                             (38)         (6)          (37)                                                
      Ectopic Parathyroid Gland                        1 (3%)       2 (33%)                                                         
      Hyperplasia, Diffuse, Tubular                    6 (16%)                  14 (38%)                                            
      Infiltration Cellular, Polymorphonuclear         1 (3%)                                                                       
      Artery, Mediastinum, Inflammation, Chronic                                                                                    
          Active, Multifocal                           1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (29)         (49)                                                
      Ectasia, Diffuse                                              3 (10%)      1 (2%)                                             
      Ectasia, Focal                                   2 (4%)                    2 (4%)                                             
      Ectasia, Multifocal                             12 (25%)     10 (34%)     15 (31%)                                            
      Galactocele                                                   1 (3%)                                                          
      Hyperplasia, Diffuse                            14 (29%)     11 (38%)     15 (31%)                                            
      Hyperplasia, Focal                               1 (2%)       1 (3%)       2 (4%)                                             
      Hyperplasia, Multifocal                          4 (8%)                                                                       
      Inflammation, Granulomatous, Multifocal          2 (4%)                                                                       
      Artery, Inflammation, Chronic Active, Focal                                1 (2%)                                             
   Skin                                               (50)         (13)         (50)                                                
      Hyperplasia, Focal, Squamous                                               1 (2%)                                             
      Inflammation, Chronic Active, Focal                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (9)          (50)                                                
      Hyperostosis                                     1 (2%)                    2 (4%)                                             
      Osteopetrosis                                    1 (2%)                    5 (10%)                                            
   Skeletal Muscle                                                              (1)                                                 
      Inflammation, Diffuse, Proliferative                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
      Compression                                     11 (22%)      1 (9%)      16 (32%)                                            
      Hemorrhage, Focal                                2 (4%)                                                                       
      Hemorrhage, Multifocal                           1 (2%)       1 (9%)                                                          
      Hydrocephalus                                    2 (4%)       1 (9%)       5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (46)         (6)          (40)                                                
      Hyperplasia, Focal, Papillary                                              1 (3%)                                             
      Inflammation, Acute, Diffuse                                               1 (3%)                                             
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
      Inflammation, Chronic, Focal                     4 (9%)                    3 (8%)                                             
      Inflammation, Chronic Active, Focal             10 (22%)                   4 (10%)                                            
      Submucosa, Dilatation, Multifocal                1 (2%)                                                                       
   Lung                                               (50)         (50)         (50)                                                
      Atelectasis, Focal                                                         1 (2%)                                             
      Autolysis                                        1 (2%)                                                                       
      Granuloma, Multifocal                                         1 (2%)                                                          
      Hemorrhage, Acute, Multifocal                    1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal                       5 (10%)      1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Multifocal                  1 (2%)                                                          
      Alveolus, Infiltration Cellular, Focal,                                                                                       
          Histiocyte                                                1 (2%)                                                          
      Bronchiole, Alveolus, Inflammation, Acute,                                                                                    
           Multifocal                                                            1 (2%)                                             
      Interstitium, Inflammation, Chronic, Focal       2 (4%)                                                                       
      Interstitium, Inflammation, Chronic,                                                                                          
          Multifocal                                   1 (2%)       1 (2%)       1 (2%)                                             
      Peribronchial, Hyperplasia, Lymphoid,                                                                                         
          Multifocal                                   2 (4%)                                                                       
      Pleura, Inflammation, Multifocal, Subacute                                 1 (2%)                                             
   Nose                                               (50)         (49)         (50)                                                
      Lumen, Exudate                                   1 (2%)       4 (8%)       2 (4%)                                             
      Lumen, Foreign Body                              2 (4%)                    1 (2%)                                             
      Mucosa, Inflammation, Acute                                                1 (2%)                                             
      Mucosa, Inflammation, Chronic                    2 (4%)       2 (4%)       1 (2%)                                             
      Mucosa, Inflammation, Chronic Active             1 (2%)       4 (8%)       4 (8%)                                             
      Mucosa, Metaplasia, Focal                        1 (2%)                                                                       
      Mucosa, Thrombosis, Multifocal                   2 (4%)       4 (8%)                                                          
      Nasolacrimal Duct, Exudate                       5 (10%)      3 (6%)       4 (8%)                                             
      Nasolacrimal Duct, Inflammation, Chronic        13 (26%)     17 (35%)     16 (32%)                                            
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
          Active                                       5 (10%)      1 (2%)       4 (8%)                                             
      Olfactory Epithelium, Atrophy                                 2 (4%)       3 (6%)                                             
      Olfactory Epithelium, Cyst                                    5 (10%)     13 (26%)                                            
      Olfactory Epithelium, Erosion                                 3 (6%)       4 (8%)                                             
      Olfactory Epithelium, Exudate                                 1 (2%)                                                          
      Olfactory Epithelium, Hyperplasia, Eosinophil    2 (4%)       9 (18%)     21 (42%)                                            
      Olfactory Epithelium, Metaplasia                              1 (2%)                                                          
      Respiratory Epithelium, Cyst                                  6 (12%)     10 (20%)                                            
      Respiratory Epithelium, Hyperplasia              7 (14%)     19 (39%)     16 (32%)                                            
      Respiratory Epithelium, Hyperplasia,                                                                                          
          Eosinophil                                                             3 (6%)                                             
      Respiratory Epithelium, Hyperplasia,                                                                                          
          Multifocal                                   1 (2%)                                                                       
   Trachea                                            (50)         (8)          (50)                                                
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (3)          (5)                                                 
      Cataract                                         1 (50%)                   1 (20%)                                            
      Bilateral, Cataract                                           1 (33%)      1 (20%)                                            
      Bilateral, Retina, Degeneration                               1 (33%)                                                         
      Retina, Degeneration                             1 (50%)                   1 (20%)                                            
   Harderian Gland                                                              (2)                                                 
      Inflammation, Chronic, Multifocal                                          2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (14)         (50)                                                
      Hydronephrosis                                                             1 (2%)                                             
      Nephropathy, Chronic                            46 (92%)      6 (43%)     43 (86%)                                            
      Pigmentation, Diffuse                            8 (16%)      2 (14%)     11 (22%)                                            
      Pigmentation, Multifocal                        11 (22%)      1 (7%)       6 (12%)                                            
      Bilateral, Hydronephrosis                                                  1 (2%)                                             
      Cortex, Cyst                                     1 (2%)                                                                       
      Cortex, Hyperplasia, Atypical, Focal             2 (4%)                    1 (2%)                                             
      Cortex, Inflammation, Focal, Suppurative         1 (2%)                                                                       
      Cortex, Mineralization, Multifocal                                         1 (2%)                                             
      Corticomedullary Junction, Mineralization,                                                                                    
           Multifocal                                                            1 (2%)                                             
      Pelvis, Inflammation, Diffuse, Suppurative                                 1 (2%)                                             
      Proximal Convoluted Renal Tubule, Necrosis,                                                                                   
           Multifocal                                  2 (4%)                                                                       
      Transitional Epithelium, Hyperplasia                                       3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Mineralization,                                                                                      
           Focal                                       1 (2%)                    1 (2%)                                             
      Transitional Epithelium, Mineralization,                                                                                      
           Multifocal                                  3 (6%)                    3 (6%)                                             
   Urinary Bladder                                    (49)         (9)          (46)                                                
      Ectasia                                                                    2 (4%)                                             
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Artery, Inflammation, Chronic Active,                                                                                         
          Multifocal                                                             1 (2%)                                             
      Transitional Epithelium, Hyperplasia, Focal                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           29           28                                                  
    Natural Death                                      6            4            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           17           19                                                  
  Wrong Sex                                            1                                                                            
  Animals Examined Microscopically                    49           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (43)         (9)          (47)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Parasite Metazoan                                2 (5%)                    4 (9%)                                             
   Intestine Large, Colon                             (46)         (13)         (49)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Mineralization, Multifocal                                                 1 (2%)                                             
      Parasite Metazoan                                4 (9%)                    6 (12%)                                            
      Artery, Inflammation, Chronic Active, Focal                                1 (2%)                                             
   Intestine Large, Rectum                            (36)         (12)         (40)                                                
      Parasite Metazoan                                2 (6%)                    2 (5%)                                             
      Artery, Submucosa, Inflammation, Chronic                                                                                      
          Active, Multifocal                           1 (3%)                                                                       
   Intestine Small, Duodenum                          (45)         (14)         (48)                                                
      Inflammation, Acute, Multifocal                               1 (7%)                                                          
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
      Ulcer, Two                                       1 (2%)                                                                       
   Intestine Small, Ileum                             (44)         (12)         (44)                                                
      Inflammation, Chronic Active, Multifocal                                   1 (2%)                                             
   Liver                                              (49)         (42)         (50)                                                
      Angiectasis, Focal                               3 (6%)       3 (7%)       2 (4%)                                             
      Angiectasis, Multifocal                          3 (6%)                    3 (6%)                                             
      Basophilic Focus                                 1 (2%)       4 (10%)      3 (6%)                                             
      Basophilic Focus, Multiple                       1 (2%)       3 (7%)       1 (2%)                                             
      Congestion                                                    2 (5%)                                                          
      Cytomegaly, Focal                                             1 (2%)                                                          
      Cytomegaly, Multifocal                                        1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    2 (4%)                    1 (2%)                                             
      Degeneration, Ballooning, Focal                  3 (6%)                    3 (6%)                                             
      Eosinophilic Focus                               1 (2%)       1 (2%)       1 (2%)                                             
      Eosinophilic Focus, Multiple                     1 (2%)                                                                       
      Fatty Change, Diffuse                            1 (2%)       3 (7%)       1 (2%)                                             
      Fatty Change, Focal                              2 (4%)       1 (2%)                                                          
      Fatty Change, Multifocal                         1 (2%)       3 (7%)       8 (16%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Granuloma, Multifocal                            4 (8%)                    4 (8%)                                             
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Hemorrhage, Multifocal                           2 (4%)                    1 (2%)                                             
      Hepatodiaphragmatic Nodule                       3 (6%)       3 (7%)       3 (6%)                                             
      Hepatodiaphragmatic Nodule, Multiple                          1 (2%)                                                          
      Hyperplasia, Focal, Nodular                                                1 (2%)                                             
      Hyperplasia, Multifocal, Nodular                 1 (2%)                                                                       
      Mitotic Alteration                                            2 (5%)                                                          
      Necrosis, Focal                                               1 (2%)       1 (2%)                                             
      Necrosis, Multifocal                            12 (24%)      3 (7%)       8 (16%)                                            
      Pigmentation, Multifocal                                      1 (2%)                                                          
      Thrombosis, Two                                  1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal                         1 (2%)                                                          
      Bile Duct, Fibrosis, Multifocal                  2 (4%)                    1 (2%)                                             
      Bile Duct, Hyperplasia, Multifocal              32 (65%)     23 (55%)     30 (60%)                                            
      Centrilobular, Congestion, Diffuse               1 (2%)                                                                       
      Centrilobular, Degeneration, Diffuse             2 (4%)       5 (12%)      1 (2%)                                             
      Centrilobular, Degeneration, Multifocal                                    4 (8%)                                             
      Centrilobular, Fatty Change, Diffuse            11 (22%)      2 (5%)       4 (8%)                                             
      Centrilobular, Fatty Change, Multifocal          1 (2%)                                                                       
      Centrilobular, Necrosis, Diffuse                 5 (10%)                                                                      
      Centrilobular, Necrosis, Multifocal              1 (2%)       1 (2%)                                                          
      Periportal, Cytomegaly, Diffuse                                            1 (2%)                                             
      Periportal, Fatty Change, Diffuse                1 (2%)       1 (2%)       2 (4%)                                             
      Portal, Fibrosis, Multifocal                                  1 (2%)                                                          
      Portal, Inflammation, Chronic, Multifocal        1 (2%)                                                                       
      Portal, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   2 (4%)       1 (2%)                                                          
   Mesentery                                          (8)          (4)          (6)                                                 
      Accessory Spleen, Two                                                      1 (17%)                                            
      Hemorrhage, Acute, Multifocal                    1 (13%)                                                                      
      Inflammation, Chronic Active, Multifocal                                   1 (17%)                                            
      Artery, Ectasia, Multifocal                                   1 (25%)                                                         
      Artery, Inflammation, Chronic, Focal                                       1 (17%)                                            
      Artery, Inflammation, Chronic, Multifocal        1 (13%)      1 (25%)                                                         
      Artery, Mineralization, Multifocal                            1 (25%)      1 (17%)                                            
      Fat, Necrosis, Focal                                          1 (25%)                                                         
   Pancreas                                           (46)         (19)         (49)                                                
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte    2 (4%)                                                                       
      Acinus, Atrophy, Diffuse                         3 (7%)       1 (5%)                                                          
      Acinus, Atrophy, Focal                           5 (11%)                   2 (4%)                                             
      Acinus, Atrophy, Multifocal                     18 (39%)      2 (11%)     20 (41%)                                            
      Acinus, Hyperplasia, Focal                                                 1 (2%)                                             
      Acinus, Hyperplasia, Multifocal                  1 (2%)                                                                       
      Artery, Ectasia, Multifocal                                   1 (5%)                                                          
      Artery, Fibrosis                                              1 (5%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation, Chronic, Multifocal                     1 (5%)                                                          
      Artery, Inflammation, Chronic Active, Focal                                2 (4%)                                             
      Artery, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   2 (4%)                    1 (2%)                                             
      Artery, Mineralization, Multifocal                            1 (5%)                                                          
   Pharynx                                            (1)          (1)          (1)                                                 
      Inflammation, Chronic Active, Multifocal                      1 (100%)                                                        
      Palate, Inflammation, Chronic, Focal             1 (100%)                  1 (100%)                                           
   Salivary Glands                                    (48)         (18)         (50)                                                
      Artery, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)                                                                       
   Stomach, Forestomach                               (48)         (13)         (49)                                                
      Inflammation, Chronic Active                     5 (10%)      2 (15%)      5 (10%)                                            
      Mineralization, Diffuse                                                    1 (2%)                                             
      Ulcer                                            3 (6%)       1 (8%)       3 (6%)                                             
      Epithelium, Hyperplasia                          6 (13%)      2 (15%)      6 (12%)                                            
      Submucosa, Edema, Diffuse                                                  1 (2%)                                             
      Submucosa, Inflammation, Subacute                1 (2%)                                                                       
   Stomach, Glandular                                 (47)         (14)         (50)                                                
      Cyst, Multiple                                   1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (7%)                                                          
      Inflammation, Chronic Active, Focal                                        1 (2%)                                             
      Mineralization, Diffuse                                                    1 (2%)                                             
      Mineralization, Multifocal                       1 (2%)                                                                       
      Ulcer, Acute                                     2 (4%)                                                                       
   Tooth                                              (2)          (3)          (1)                                                 
      Dysplasia                                                     3 (100%)                                                        
      Pulp, Angiectasis                                1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (14)         (50)                                                
      Cardiomyopathy                                  42 (86%)     10 (71%)     40 (80%)                                            
      Mineralization, Multifocal                                                 1 (2%)                                             
      Atrium Left, Thrombosis                          4 (8%)       1 (7%)       2 (4%)                                             
      Endocardium, Atrium, Fibrosis, Focal             1 (2%)                                                                       
      Myocardium, Fibrosis, Focal                                                1 (2%)                                             
      Valve, Fibrosis, Focal                           1 (2%)                    1 (2%)                                             
      Valve, Inflammation, Focal, Proliferative                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (24)         (50)                                                
      Capsule, Accessory Adrenal Cortical Nodule       5 (10%)      2 (8%)       4 (8%)                                             
   Adrenal Gland, Cortex                              (49)         (20)         (50)                                                
      Cytoplasmic Alteration, Focal                    1 (2%)                    1 (2%)                                             
      Degeneration, Diffuse, Fatty                    13 (27%)      5 (25%)      9 (18%)                                            
      Degeneration, Fatty, Focal                       6 (12%)      4 (20%)      6 (12%)                                            
      Degeneration, Fatty, Multifocal                  3 (6%)       1 (5%)       3 (6%)                                             
      Hyperplasia, Focal                               4 (8%)       2 (10%)     10 (20%)                                            
      Hyperplasia, Multifocal                          3 (6%)                    2 (4%)                                             
      Hypertrophy, Focal                                            2 (10%)      1 (2%)                                             
      Hypertrophy, Multifocal                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (21)         (46)                                                
      Angiectasis, Focal                               1 (2%)                                                                       
      Hyperplasia, Focal                               8 (16%)      3 (14%)      5 (11%)                                            
      Hyperplasia, Multifocal                         10 (20%)      2 (10%)      4 (9%)                                             
   Islets, Pancreatic                                 (46)         (16)         (49)                                                
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                               2 (4%)                    2 (4%)                                             
      Hyperplasia, Multifocal                          1 (2%)       2 (13%)      5 (10%)                                            
      Inflammation, Multifocal                                                   1 (2%)                                             
   Parathyroid Gland                                  (45)         (14)         (45)                                                
      Hyperplasia                                      1 (2%)       2 (14%)      5 (11%)                                            
   Pituitary Gland                                    (49)         (35)         (50)                                                
      Pars Distalis, Angiectasis                       2 (4%)       1 (3%)       3 (6%)                                             
      Pars Distalis, Cyst                              1 (2%)       4 (11%)      5 (10%)                                            
      Pars Distalis, Degeneration, Fatty, Focal                                  1 (2%)                                             
      Pars Distalis, Hyperplasia                                    1 (3%)       2 (4%)                                             
      Pars Distalis, Hyperplasia, Diffuse,                                                                                          
          Eosinophil                                   1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                2 (4%)       3 (9%)       7 (14%)                                            
      Pars Distalis, Hyperplasia, Multifocal           5 (10%)                                                                      
      Pars Distalis, Pigmentation, Focal               1 (2%)                                                                       
      Pars Intermedia, Hyperplasia                     2 (4%)                                                                       
   Thyroid Gland                                      (49)         (20)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Mineralization, Multifocal                       1 (2%)                                                                       
      C-Cell, Hyperplasia, Focal                       4 (8%)       1 (5%)       2 (4%)                                             
      C-Cell, Hyperplasia, Multifocal                  4 (8%)       1 (5%)       3 (6%)                                             
      Follicle, Cyst                                                             2 (4%)                                             
      Follicular Cell, Degeneration, Multifocal        1 (2%)                    1 (2%)                                             
      Follicular Cell, Hyperplasia, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (1)                                                 
      Necrosis, Focal                                                            1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (47)         (16)         (50)                                                
      Dilatation, Multifocal                           2 (4%)                    1 (2%)                                             
      Granuloma Sperm, Single                          1 (2%)                    1 (2%)                                             
      Inflammation, Focal, Suppurative                 1 (2%)                                                                       
      Left, Atrophy                                                              1 (2%)                                             
   Preputial Gland                                    (46)         (18)         (48)                                                
      Abscess                                                       2 (11%)                                                         
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Ectasia                                          2 (4%)       2 (11%)      3 (6%)                                             
      Fibrosis, Diffuse                                2 (4%)                                                                       
      Inflammation, Chronic Active                     4 (9%)                    4 (8%)                                             
      Inflammation, Diffuse, Granulomatous             1 (2%)                    1 (2%)                                             
      Inflammation, Focal, Granulomatous               4 (9%)                    3 (6%)                                             
      Inflammation, Focal, Suppurative                 1 (2%)                                                                       
      Inflammation, Granulomatous, Multifocal         18 (39%)      4 (22%)     22 (46%)                                            
   Prostate                                           (49)         (18)         (49)                                                
      Hyperplasia, Focal                               5 (10%)                   5 (10%)                                            
      Hyperplasia, Multifocal                          3 (6%)       2 (11%)      6 (12%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                     8 (16%)      6 (33%)     13 (27%)                                            
   Seminal Vesicle                                    (41)         (13)         (43)                                                
      Atrophy, Diffuse                                 3 (7%)                    5 (12%)                                            
      Fibrosis, Multifocal                                                       1 (2%)                                             
      Inflammation, Chronic Active, Diffuse,                                                                                        
          Suppurative                                                            1 (2%)                                             
      Inflammation, Diffuse, Subacute                  1 (2%)                                                                       
   Testes                                             (49)         (42)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Mineralization, Focal                            1 (2%)                                                                       
      Mineralization, Multifocal                       1 (2%)       1 (2%)       1 (2%)                                             
      Arteriole, Inflammation                          6 (12%)      2 (5%)       4 (8%)                                             
      Capsule, Hyperplasia, Multifocal                                           1 (2%)                                             
      Interstitial Cell, Hyperplasia                   2 (4%)       4 (10%)      2 (4%)                                             
      Seminiferous Tubule, Atrophy                    13 (27%)     11 (26%)     13 (26%)                                            
      Seminiferous Tubule, Degeneration                2 (4%)                    4 (8%)                                             
      Serosa, Necrosis, Focal                          1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (15)         (50)                                                
      Atrophy                                                       1 (7%)                                                          
      Hyperplasia                                      8 (17%)      2 (13%)      5 (10%)                                            
      Metaplasia, Osseous                              1 (2%)       1 (7%)                                                          
      Myelofibrosis                                    1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                        4 (8%)                    4 (8%)                                             
   Lymph Node                                         (49)         (27)         (50)                                                
      Inflammation, Focal, Suppurative                 1 (2%)                                                                       
      Lumbar, Hemorrhage                                                         1 (2%)                                             
      Lumbar, Inflammation, Granulomatous,                                                                                          
          Multifocal                                   1 (2%)                                                                       
      Mediastinal, Hemorrhage                          2 (4%)       2 (7%)       5 (10%)                                            
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                                                       
      Mediastinal, Hyperplasia, Re Cell                1 (2%)                                                                       
      Mediastinal, Pigmentation, Hemosiderin           2 (4%)                                                                       
      Pancreatic, Hemorrhage                                        1 (4%)                                                          
      Pancreatic, Hyperplasia, Lymphoid                2 (4%)                                                                       
   Lymph Node, Mandibular                             (44)         (14)         (48)                                                
      Hemorrhage                                                    1 (7%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (5%)                    3 (6%)                                             
      Hyperplasia, Plasma Cell                         2 (5%)       1 (7%)       5 (10%)                                            
      Hyperplasia, Re Cell                             1 (2%)                                                                       
      Inflammation, Focal, Subacute                    1 (2%)                                                                       
   Lymph Node, Mesenteric                             (44)         (17)         (48)                                                
      Depletion Lymphoid                               1 (2%)                    1 (2%)                                             
      Fibrosis, Multifocal                                                       1 (2%)                                             
      Hemorrhage                                                    2 (12%)      2 (4%)                                             
      Hyperplasia, Lymphoid                            2 (5%)                    2 (4%)                                             
      Hyperplasia, Re Cell                             1 (2%)                    3 (6%)                                             
   Spleen                                             (49)         (35)         (49)                                                
      Congestion                                                    1 (3%)       1 (2%)                                             
      Depletion Lymphoid                                                         1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)       2 (6%)       4 (8%)                                             
      Fibrosis, Multifocal                             2 (4%)       2 (6%)                                                          
      Hematopoietic Cell Proliferation                 4 (8%)       2 (6%)                                                          
      Necrosis, Coagulative, Focal                     1 (2%)                                                                       
      Pigmentation, Hemosiderin                        3 (6%)       1 (3%)       7 (14%)                                            
      Thrombosis, Single                                                         1 (2%)                                             
      Capsule, Fibrosis, Focal                                                   1 (2%)                                             
      Capsule, Fibrosis, Multifocal                    1 (2%)                    1 (2%)                                             
   Thymus                                             (38)         (14)         (38)                                                
      Angiectasis, Multifocal                                       1 (7%)                                                          
      Depletion Lymphoid                                                         1 (3%)                                             
      Hemorrhage                                       1 (3%)       1 (7%)                                                          
      Hyperplasia, Tubular                             8 (21%)      2 (14%)      6 (16%)                                            
      Artery, Inflammation, Chronic Active             1 (3%)                    1 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (38)         (20)         (46)                                                
      Ectasia, Diffuse                                 9 (24%)      4 (20%)      4 (9%)                                             
      Ectasia, Multifocal                             14 (37%)      7 (35%)      6 (13%)                                            
      Granuloma                                                                  1 (2%)                                             
      Hyperplasia, Diffuse                             3 (8%)       2 (10%)      7 (15%)                                            
      Hyperplasia, Focal                                                         1 (2%)                                             
      Inflammation, Chronic Active, Multifocal         2 (5%)                                                                       
      Inflammation, Granulomatous                                   1 (5%)                                                          
      Inflammation, Proliferative                      2 (5%)                                                                       
   Skin                                               (49)         (23)         (50)                                                
      Cyst Epithelial Inclusion                        1 (2%)       3 (13%)                                                         
      Hyperkeratosis                                   1 (2%)       2 (9%)                                                          
      Hyperplasia, Squamous                            1 (2%)       1 (4%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                    1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Artery, Subcutaneous Tissue, Inflammation,                                                                                    
           Chronic Active, Focal                       1 (2%)                                                                       
      Subcutaneous Tissue, Cyst                                                  1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage, Chronic,                                                                                     
           Focal                                       1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    2 (9%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (18)         (50)                                                
      Fibrous Osteodystrophy                                        3 (17%)      2 (4%)                                             
      Osteopetrosis                                                              1 (2%)                                             
      Sternum, Developmental Malformation              1 (2%)                                                                       
   Skeletal Muscle                                    (2)          (4)          (1)                                                 
      Hemorrhage, Acute                                             2 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (15)         (50)                                                
      Compression                                     11 (22%)      5 (33%)      9 (18%)                                            
      Hemorrhage, Focal                                4 (8%)                    1 (2%)                                             
      Hemorrhage, Multifocal                           1 (2%)                    2 (4%)                                             
      Hydrocephalus                                    3 (6%)       2 (13%)      8 (16%)                                            
      Perivascular, Infiltration Cellular,                                                                                          
          Multifocal, Mixed Cell                                    1 (7%)                                                          
      Thalamus, Gliosis, Focal                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (37)         (5)          (41)                                                
      Inflammation, Chronic, Multifocal                                          2 (5%)                                             
      Inflammation, Chronic Active, Focal              7 (19%)      1 (20%)      5 (12%)                                            
      Inflammation, Focal, Suppurative                 1 (3%)                                                                       
      Submucosa, Dilatation                                                      1 (2%)                                             
   Lung                                               (49)         (50)         (50)                                                
      Edema, Focal                                     1 (2%)                                                                       
      Hemorrhage, Multifocal, Subacute                 1 (2%)                    1 (2%)                                             
      Mineralization, Multifocal                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal                       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Multifocal                  2 (4%)                                                          
      Artery, Mineralization, Focal                                              1 (2%)                                             
      Bronchus, Hyperplasia, Focal, Lymphoid                                     1 (2%)                                             
      Bronchus, Epithelium, Hyperplasia, Focal         1 (2%)                                                                       
      Interstitium, Inflammation, Acute, Multifocal                              1 (2%)                                             
      Interstitium, Inflammation, Chronic, Diffuse                  1 (2%)                                                          
      Interstitium, Inflammation, Chronic, Focal       1 (2%)                                                                       
      Interstitium, Inflammation, Chronic,                                                                                          
          Multifocal                                   2 (4%)       4 (8%)       2 (4%)                                             
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                                            2 (4%)                                             
      Interstitium, Mineralization, Multifocal                      1 (2%)                                                          
      Vein, Mineralization, Multifocal                 1 (2%)                                                                       
   Nose                                               (48)         (50)         (50)                                                
      Lumen, Exudate                                   2 (4%)       5 (10%)      2 (4%)                                             
      Lumen, Foreign Body                              2 (4%)       5 (10%)      4 (8%)                                             
      Mucosa, Inflammation, Chronic                    4 (8%)       4 (8%)       6 (12%)                                            
      Mucosa, Inflammation, Chronic Active             2 (4%)       9 (18%)      4 (8%)                                             
      Mucosa, Thrombosis, Multifocal                   5 (10%)      5 (10%)      3 (6%)                                             
      Nasolacrimal Duct, Exudate                       1 (2%)       3 (6%)       3 (6%)                                             
      Nasolacrimal Duct, Fungus                                                  1 (2%)                                             
      Nasolacrimal Duct, Hyperplasia                   1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute                        1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Chronic        14 (29%)     16 (32%)     10 (20%)                                            
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       5 (10%)      1 (2%)       5 (10%)                                            
      Olfactory Epithelium, Atrophy                    2 (4%)       1 (2%)       3 (6%)                                             
      Olfactory Epithelium, Cyst                                    4 (8%)       6 (12%)                                            
      Olfactory Epithelium, Erosion                                 8 (16%)      1 (2%)                                             
      Olfactory Epithelium, Hyperplasia, Eosinophil    1 (2%)                                                                       
      Olfactory Epithelium, Inflammation, Chronic                                                                                   
          Active                                                                 1 (2%)                                             
      Olfactory Epithelium, Metaplasia                              6 (12%)      4 (8%)                                             
      Respiratory Epithelium, Cyst                     2 (4%)      13 (26%)      9 (18%)                                            
      Respiratory Epithelium, Hyperplasia              8 (17%)     24 (48%)     27 (54%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Respiratory Epithelium, Hyperplasia,                                                                                          
          Eosinophil                                   4 (8%)                    1 (2%)                                             
      Respiratory Epithelium, Hyperplasia,                                                                                          
          Papillary                                                 5 (10%)      2 (4%)                                             
   Trachea                                            (48)         (14)         (50)                                                
      Inflammation, Chronic                                         1 (7%)       2 (4%)                                             
      Artery, Inflammation, Chronic Active, Focal      1 (2%)                                                                       
      Glands, Metaplasia, Focal, Squamous                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)          (5)                                                 
      Anterior, Synechia                                            1 (50%)                                                         
      Choroid, Left, Hemorrhage                        1 (33%)                                                                      
      Cornea, Inflammation, Chronic Active                          1 (50%)                                                         
      Lens, Right, Cataract                                         1 (50%)                                                         
      Retina, Degeneration                             1 (33%)      1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (35)         (50)                                                
      Bacterium                                                     1 (3%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (3%)                                                          
      Inflammation, Acute, Multifocal, Suppurative                  1 (3%)                                                          
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Mineralization, Diffuse                                                    1 (2%)                                             
      Nephropathy, Chronic                            46 (94%)     32 (91%)     48 (96%)                                            
      Pigmentation, Diffuse                            8 (16%)      2 (6%)       5 (10%)                                            
      Pigmentation, Multifocal                         2 (4%)       1 (3%)       1 (2%)                                             
      Artery, Inflammation, Chronic Active, Focal                                1 (2%)                                             
      Cortex, Cyst                                     1 (2%)       1 (3%)       3 (6%)                                             
      Cortex, Hyperplasia, Atypical                    1 (2%)                    2 (4%)                                             
      Proximal Convoluted Renal Tubule, Necrosis,                                                                                   
           Acute, Multifocal                                                     1 (2%)                                             
      Transitional Epithelium, Hyperplasia             2 (4%)                                                                       
      Transitional Epithelium, Mineralization          4 (8%)                                                                       
   Urinary Bladder                                    (48)         (12)         (49)                                                
      Calculus Gross Observation                       1 (2%)                                                                       
      Ectasia                                                                    1 (2%)                                             
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
      Inflammation, Diffuse, Subacute                                            1 (2%)                                             
      Lumen, Calculus Micro Observation Only,                                                                                       
          Single                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05070-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           VINYL TOLUENE                                       Date: 09/08/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:35:03  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      100 PPM      300 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Subserosa, Mineralization, Focal                                           1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
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