TDMS Study 05070-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
VINYL TOLUENE
NTP Experiment-Test: 05070-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
Facility: Midwest Research Institute
Chemical CAS #: 25013154
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 16 21 18
Natural Death 3 1 6
Survivors
Terminal Sacrifice 31 28 26
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (5) (46)
Intestine Large, Colon (50) (10) (49)
Intestine Large, Rectum (46) (9) (46)
Intestine Small, Duodenum (50) (9) (50)
Intestine Small, Ileum (48) (7) (48)
Intestine Small, Jejunum (48) (7) (49)
Liver (50) (33) (50)
Mesentery (4) (2) (5)
Fibrosarcoma, Metastatic, Skin 1 (50%)
Fat, Lipoma 1 (25%)
Pancreas (50) (13) (49)
Carcinoma 1 (2%)
Salivary Glands (50) (9) (47)
Stomach, Forestomach (49) (11) (49)
Stomach, Glandular (50) (11) (50)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50)
Hemangiosarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (14) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (48) (14) (45)
Pheochromocytoma Malignant 2 (4%) 1 (2%)
Pheochromocytoma Benign 5 (10%) 3 (7%)
Page 2
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (50) (12) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%) 1 (8%) 2 (4%)
Pituitary Gland (50) (43) (50)
Pars Distalis, Adenoma 25 (50%) 24 (56%) 24 (48%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Distalis, Adenoma, Two 3 (6%) 1 (2%) 4 (8%)
Pars Distalis, Carcinoma 4 (8%) 2 (5%) 1 (2%)
Thyroid Gland (50) (10) (50)
Carcinoma 1 (2%)
C-Cell, Adenoma 7 (14%) 2 (4%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Adenoma, Papillary 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (48) (11) (46)
Adenoma 1 (2%) 2 (18%) 2 (4%)
Carcinoma 2 (18%)
Duct, Squamous Cell Papilloma 1 (2%)
Ovary (50) (18) (50)
Uterus (50) (18) (50)
Adenoma 1 (2%)
Leiomyoma 1 (6%) 1 (2%)
Leiomyosarcoma 1 (2%) 1 (6%)
Polyp Stromal 7 (14%) 6 (33%) 5 (10%)
Sarcoma Stromal 1 (2%)
Vagina (1) (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (9) (50)
Lymph Node (50) (17) (50)
Lymph Node, Mandibular (47) (11) (47)
Lymph Node, Mesenteric (47) (12) (46)
Spleen (50) (19) (50)
Thymus (38) (6) (37)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (29) (49)
Adenocarcinoma 3 (6%) 2 (4%)
Adenoma 1 (3%) 1 (2%)
Carcinoma 1 (3%)
Fibroadenoma 13 (27%) 8 (28%) 9 (18%)
Fibroadenoma, Multiple 1 (2%)
Fibroadenoma, Two 2 (4%)
Skin (50) (13) (50)
Basal Cell Carcinoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (6%) 2 (15%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (8%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Myxoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (9) (50)
Sternum, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Trachea (50) (8) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (14) (50)
Urinary Bladder (49) (9) (46)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 20 (40%) 16 (32%) 25 (50%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 41 46
Total Primary Neoplasms 108 70 97
Total Animals with Benign Neoplasms 44 34 39
Total Benign Neoplasms 73 46 57
Total Animals with Malignant Neoplasms 28 23 31
Total Malignant Neoplasms 35 24 40
Total Animals with Metastatic Neoplasms 1 2
Total Metastatic Neoplasm 1 2
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 24 29 28
Natural Death 6 4 3
Survivors
Terminal Sacrifice 19 17 19
Wrong Sex 1
Animals Examined Microscopically 49 50 50
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ALIMENTARY SYSTEM
Intestine Large, Cecum (43) (9) (47)
Intestine Large, Colon (46) (13) (49)
Serosa, Carcinoma, Metastatic, Intestine
Small 1 (2%)
Intestine Small, Ileum (44) (12) (44)
Jejunum, Adenocarcinoma, Mucinous 1 (2%)
Intestine Small, Jejunum (45) (13) (47)
Adenocarcinoma 1 (2%)
Liver (49) (42) (50)
Fibrosarcoma, Metastatic 1 (2%)
Neoplastic Nodule 2 (4%) 2 (5%) 1 (2%)
Mesentery (8) (4) (6)
Fat, Adenocarcinoma, Metastatic, Intestine
Small 1 (13%)
Pancreas (46) (19) (49)
Pharynx (1) (1) (1)
Palate, Squamous Cell Papilloma 1 (100%) 1 (100%)
Salivary Glands (48) (18) (50)
Fibrosarcoma 1 (6%)
Stomach, Forestomach (48) (13) (49)
Stomach, Glandular (47) (14) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (14) (50)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (24) (50)
Adrenal Gland, Cortex (49) (20) (50)
Adenoma 2 (4%)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (49) (21) (46)
Pheochromocytoma Malignant 1 (2%) 3 (14%) 2 (4%)
Pheochromocytoma Complex 3 (6%) 1 (2%)
Pheochromocytoma Benign 11 (22%) 6 (29%) 11 (24%)
Pheochromocytoma Benign, Multiple 3 (6%) 3 (7%)
Islets, Pancreatic (46) (16) (49)
Adenoma 5 (11%) 3 (19%) 5 (10%)
Adenoma, Two 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (45) (14) (45)
Adenoma 1 (2%)
Pituitary Gland (49) (35) (50)
Pars Distalis, Adenoma 27 (55%) 20 (57%) 28 (56%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Distalis, Adenoma, Two 3 (6%) 1 (3%) 1 (2%)
Pars Distalis, Carcinoma 3 (6%) 1 (3%) 1 (2%)
Thyroid Gland (49) (20) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 7 (14%) 2 (10%) 6 (12%)
C-Cell, Carcinoma 1 (2%) 1 (5%) 1 (2%)
Follicular Cell, Carcinoma 2 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Lipoma 1 (100%)
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GENITAL SYSTEM
Epididymis (47) (16) (50)
Preputial Gland (46) (18) (48)
Adenoma 1 (2%) 2 (4%)
Carcinoma 1 (2%) 2 (11%) 1 (2%)
Prostate (49) (18) (49)
Adenoma 1 (2%)
Seminal Vesicle (41) (13) (43)
Adenocarcinoma, Metastatic, Intestine Small 1 (2%)
Testes (49) (42) (50)
Bilateral, Interstitial Cell, Adenoma 25 (51%) 21 (50%) 33 (66%)
Interstitial Cell, Adenoma 10 (20%) 10 (24%) 8 (16%)
Page 8
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (15) (50)
Lymph Node (49) (27) (50)
Inguinal, Renal, Adenocarcinoma, Metastatic,
Intestine Small 1 (2%)
Mediastinal, Pheochromocytoma Malignant,
Metastatic, Adrenal Gland 1 (4%)
Lymph Node, Mandibular (44) (14) (48)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (44) (17) (48)
Spleen (49) (35) (49)
Thymus (38) (14) (38)
Thymoma Malignant 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (38) (20) (46)
Adenocarcinoma 1 (5%) 1 (2%)
Fibroadenoma 1 (3%) 1 (2%)
Skin (49) (23) (50)
Basosquamous Tumor Benign 1 (4%)
Keratoacanthoma 2 (4%) 3 (13%) 5 (10%)
Keratoacanthoma, Two 1 (4%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 3 (6%) 1 (4%) 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (4) (1)
Hindlimb, Rhabdomyosarcoma 1 (25%)
Intercostal, Fibroma 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (15) (50)
Astrocytoma NOS 1 (2%)
Carcinoma, Early Invasion 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Page 9
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (37) (5) (41)
Carcinoma, Metastatic, Thyroid Gland 1 (3%)
Lung (49) (50) (50)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Fibrosarcoma, Metastatic 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Pheochromocytoma Complex, Metastatic 1 (2%)
Trachea (48) (14) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Right, Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (35) (50)
Lipoma 2 (4%)
Sarcoma 1 (2%)
Urinary Bladder (48) (12) (49)
Transitional Epithelium, Papilloma 2 (4%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(49) *(50) *(50)
Leukemia Mononuclear 25 (51%) 26 (52%) 20 (40%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05070-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC VINYL TOLUENE Date: 09/08/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:35:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 300 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 50 50
Total Primary Neoplasms 152 116 149
Total Animals with Benign Neoplasms 48 45 49
Total Benign Neoplasms 108 73 115
Total Animals with Malignant Neoplasms 38 37 29
Total Malignant Neoplasms 43 43 34
Total Animals with Metastatic Neoplasms 5 1 1
Total Metastatic Neoplasm 12 2 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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