TDMS Study 05070-01 Pathology Tables
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
Facility: Midwest Research Institute
Chemical CAS #: 25013154
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|
| 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X X|
Artery, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X|
Muscularis, Atrophy, Focal | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + M|
Parasite Metazoan | X X |
Mucosa, Inflammation, Chronic Active,| |
Multifocal | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + M + + + + + + +|
Inflammation, Chronic, Diffuse | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X X X X X X X X|
Clear Cell Focus | X |
Cytomegaly, Multifocal | 3 |
Cytoplasmic Alteration, Focal | |
Eosinophilic Focus | |
Fatty Change, Diffuse | 3 2 |
Fatty Change, Multifocal | |
Fibrosis, Multifocal | 2 |
Granuloma, Multifocal | 2 4 3 2 1 1 2 2 2 2 2 |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | X |
Hyperplasia, Multifocal, Nodular | 2 |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
Necrosis, Multifocal | 1 2 2 2 2 |
Bile Duct, Hyperplasia, Focal | 2 |
Bile Duct, Hyperplasia, Multifocal | 1 2 1 |
Centrilobular, Atrophy, Multifocal | |
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Fatty Change, Diffuse | 4 2 |
Centrilobular, Necrosis, Multifocal | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|
| 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | 1 |
Acinus, Atrophy, Multifocal | 2 2 2 1 2 1 1 |
Acinus, Hyperplasia, Focal | 3 |
Artery, Inflammation, Chronic, Focal | 2 |
Artery, Inflammation, Chronic Active,| |
Multifocal | 2 |
Interlobular, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | 4 |
Inflammation, Chronic Active, Focal | 2 |
Duct, Inflammation, Chronic Active, | |
Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic Active | 3 |
Ulcer, Single, Subacute | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Mucosa, Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Single | |
Cardiomyopathy | 3 2 2 2 3 1 2 2 1 2 3 2 2 3 2 3 1 2|
Artery, Inflammation, Chronic Active,| |
Multifocal | |
Atrium Left, Thrombosis | |
Valve, Degeneration, Mucoid, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 |
Angiectasis, Multifocal | 2 3|
Congestion | 4 3 2 |
Degeneration, Diffuse, Fatty | 2 |
Degeneration, Fatty, Focal | 2 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|
| 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Fatty, Multifocal | 3 |
Hyperplasia, Focal | 2 2 3 3 1 2 |
Hypertrophy, Focal | 1 |
Hypertrophy, Multifocal | |
Pigmentation, Diffuse, Hemosiderin | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
Angiectasis, Multifocal | 2 |
Hyperplasia, Focal | 1 3 3 2 |
Hyperplasia, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue, Focal | X |
Hyperplasia, Multifocal | 3 |
Hypertrophy, Focal | 2 |
Hypoplasia, Diffuse | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 4 3 |
Pars Distalis, Angiectasis, | |
Multifocal | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hemorrhage, Chronic, | |
Focal | 3 |
Pars Distalis, Hyperplasia, Focal | 3 3 |
Pars Distalis, Hyperplasia | 3 |
Pars Distalis, Pigmentation, Diffuse,| |
Hemosiderin | |
Pars Intermedia, Pigmentation, | |
Diffuse, Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia, Focal | 1 |
C-Cell, Hyperplasia, Multifocal | 2 2 1 1 1 2 2 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + M|
Hyperplasia | 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|
| 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis, Multifocal | 2 |
Congestion, Diffuse | |
Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Dilatation | 4 |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Focal | 1 |
Epithelium, Hyperplasia, Diffuse | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 2|
Metaplasia, Diffuse, Osseous | 3 |
Myeloid Cell, Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 2 |
Mediastinal, Hemorrhage | 2 3 |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + M + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + M + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Plasma Cell | |
Hyperplasia, Re Cell | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma, Multifocal | 2 |
Hematopoietic Cell Proliferation | 2 2 1|
Hyperplasia, Multifocal, Reticulum | |
Cell | |
Pigmentation, Hemosiderin | 2 3 2 2 3 2 |
Capsule, Ectopic Tissue | |
Capsule, Infiltration Cellular, | |
Multifocal, Lymphocyte | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + M M + M M + + + + + + + + + + +|
Ectopic Parathyroid Gland | X |
Hyperplasia, Diffuse, Tubular | 3 2 2 2 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
Artery, Mediastinum, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|
| 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Chronic Active, Multifocal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Ectasia, Focal | |
Ectasia, Multifocal | 2 2 2 3 2 2 2|
Hyperplasia, Diffuse | 2 2 1 2 1 2 1 2 |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
Inflammation, Granulomatous, | |
Multifocal | 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperostosis | |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X |
Hemorrhage, Focal | 1 |
Hemorrhage, Multifocal | |
Hydrocephalus | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + M + M + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Diffuse | 4 |
Inflammation, Chronic, Focal | 4 2 3 2|
Inflammation, Chronic Active, Focal | 3 1 2 3 |
Submucosa, Dilatation, Multifocal | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hemorrhage, Acute, Multifocal | 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 |
Interstitium, Inflammation, Chronic, | |
Multifocal | 3 |
Peribronchial, Hyperplasia, Lymphoid,| |
Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | |
Lumen, Foreign Body | 4 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 5| 7| 7| 1| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 3| 7| 2| 2| 1| 2| 2| 0| 2| 2| 9| 2| 4| 3| 8| 2| 2| 6| 2| 2| 2| 8| 3| 2| 1|
| 0| 9| 9| 9| 3| 9| 8| 1| 9| 9| 2| 9| 5| 0| 2| 9| 9| 6| 8| 8| 8| 8| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Chronic | 4 |
Mucosa, Inflammation, Chronic Active | |
Mucosa, Metaplasia, Focal | 3 |
Mucosa, Thrombosis, Multifocal | 3 |
Nasolacrimal Duct, Exudate | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 2 |
Olfactory Epithelium, Hyperplasia, | |
Eosinophil | 2 |
Respiratory Epithelium, Hyperplasia | 2 1 |
Respiratory Epithelium, Hyperplasia, | |
Multifocal | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 3 3 2 2 3 2 3 4 3 4 3 3 2 2 1 4 3 3 3 1 3 1|
Pigmentation, Diffuse | 1 3 1|
Pigmentation, Multifocal | 2 2 1 2 2 2 1 |
Cortex, Cyst | X |
Cortex, Hyperplasia, Atypical, Focal | |
Cortex, Inflammation, Focal, | |
Suppurative | |
Proximal Convoluted Renal Tubule, | |
Necrosis, Multifocal | |
Transitional Epithelium, | |
Mineralization, Focal | |
Transitional Epithelium, | |
Mineralization, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5| |
| 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
Parasite Metazoan | | 2 |
Artery, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 7 |
Muscularis, Atrophy, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + M + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | | 2 |
Mucosa, Inflammation, Chronic Active,| | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 1 3 3 | 3 2.3|
Basophilic Focus | X X X X X | 8 |
Basophilic Focus, Multiple | X X X X X X X X X X | 19 |
Clear Cell Focus | | 1 |
Cytomegaly, Multifocal | | 1 3.0|
Cytoplasmic Alteration, Focal | 3 | 1 3.0|
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 2 | 3 2.3|
Fatty Change, Multifocal | 1 1 1 1 1 3 4| 7 1.7|
Fibrosis, Multifocal | | 1 2.0|
Granuloma, Multifocal | 1 1 1 1 2 2 2 1 | 19 1.8|
Hepatodiaphragmatic Nodule | | 1 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Hyperplasia, Multifocal, Nodular | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 1 2.0|
Necrosis, Multifocal | 2 2 1| 8 1.8|
Bile Duct, Hyperplasia, Focal | | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | 2 1 3| 6 1.7|
Centrilobular, Atrophy, Multifocal | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5| |
| 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Centrilobular, Degeneration, Diffuse | 2 | 1 2.0|
Centrilobular, Fatty Change, Diffuse | 4 4 | 4 3.2|
Centrilobular, Necrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Diffuse | 4 | 2 3.5|
Acinus, Atrophy, Focal | | 1 1.0|
Acinus, Atrophy, Multifocal | 2 2 1 1 1 2| 13 1.5|
Acinus, Hyperplasia, Focal | | 1 3.0|
Artery, Inflammation, Chronic, Focal | 3 | 2 2.5|
Artery, Inflammation, Chronic Active,| | |
Multifocal | | 1 2.0|
Interlobular, Inflammation, Chronic, | | |
Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Diffuse | | 1 4.0|
Inflammation, Chronic Active, Focal | | 1 2.0|
Duct, Inflammation, Chronic Active, | | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 4 3 | 3 3.3|
Ulcer, Single, Subacute | 3| 1 3.0|
Epithelium, Hyperplasia | 4 2| 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Mucosa, Cyst, Multiple | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Single | 2| 1 2.0|
Cardiomyopathy | 2 2 1 3 3 3 3 2 2 2 1 2 2 2 2 2 1 2 | 36 2.1|
Artery, Inflammation, Chronic Active,| | |
Multifocal | 4 | 1 4.0|
Atrium Left, Thrombosis | 4 2| 2 3.0|
Valve, Degeneration, Mucoid, | | |
Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5| |
| 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 2 2.5|
Angiectasis, Multifocal | 1 2 | 4 2.0|
Congestion | 3 | 4 3.0|
Degeneration, Diffuse, Fatty | | 1 2.0|
Degeneration, Fatty, Focal | 2 2 2 3| 8 2.4|
Degeneration, Fatty, Multifocal | 2 | 2 2.5|
Hyperplasia, Focal | 2 1 3 | 9 2.1|
Hypertrophy, Focal | 2 4 1 | 4 2.0|
Hypertrophy, Multifocal | 2 2 | 2 2.0|
Pigmentation, Diffuse, Hemosiderin | 3 2| 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis, Multifocal | | 1 2.0|
Hyperplasia, Focal | 2 | 5 2.2|
Hyperplasia, Multifocal | 2 2| 2 2.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Tissue, Focal | | 1 |
Hyperplasia, Multifocal | 2 | 2 2.5|
Hypertrophy, Focal | 1 | 2 1.5|
Hypoplasia, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + M + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | 2 3 | 4 3.0|
Pars Distalis, Angiectasis, | | |
Multifocal | 1 4| 2 2.5|
Pars Distalis, Cyst | 3 2 2 3 | 5 2.4|
Pars Distalis, Hemorrhage, Chronic, | | |
Focal | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 3 | 3 3.0|
Pars Distalis, Hyperplasia | | 1 3.0|
Pars Distalis, Pigmentation, Diffuse,| | |
Hemosiderin | 2 | 1 2.0|
Pars Intermedia, Pigmentation, | | |
Diffuse, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5| |
| 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X 1 | 2 1.0|
C-Cell, Hyperplasia, Focal | 3 | 2 2.0|
C-Cell, Hyperplasia, Multifocal | 2 2 3 2 2 2 2 2 2 2 2 3 | 21 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 4 | 3 3.3|
Inflammation, Acute | 2 2 | 2 2.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Inflammation, Granulomatous | 4 | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | | 1 2.0|
Congestion, Diffuse | 2 | 1 2.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Dilatation | | 1 4.0|
Inflammation, Acute, Multifocal | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Endometrium, Hyperplasia, Focal | | 1 1.0|
Epithelium, Hyperplasia, Diffuse | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.0|
Metaplasia, Diffuse, Osseous | | 1 3.0|
Myeloid Cell, Hyperplasia | 4 4 2 2 | 6 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Re Cell | | 1 2.0|
Mediastinal, Hemorrhage | 3 4| 4 3.0|
Pancreatic, Hemorrhage | 4| 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5| |
| 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | 2 4| 3 2.3|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Hyperplasia, Re Cell | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma, Multifocal | | 1 2.0|
Hematopoietic Cell Proliferation | 4 3 | 5 2.4|
Hyperplasia, Multifocal, Reticulum | | |
Cell | 2 | 1 2.0|
Pigmentation, Hemosiderin | 1 2 2 3 2 | 11 2.2|
Capsule, Ectopic Tissue | X | 1 |
Capsule, Infiltration Cellular, | | |
Multifocal, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M M + M + M M + M + + + + M + + + + + + + +| 38 |
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Diffuse, Tubular | 2 | 6 2.2|
Infiltration Cellular, | | |
Polymorphonuclear | 4 | 1 4.0|
Artery, Mediastinum, Inflammation, | | |
Chronic Active, Multifocal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia, Focal | 2 2 | 2 2.0|
Ectasia, Multifocal | 2 2 2 2 1 | 12 2.0|
Hyperplasia, Diffuse | 2 1 2 2 2 3 | 14 1.8|
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia, Multifocal | 2 1 1 | 4 1.5|
Inflammation, Granulomatous, | | |
Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperostosis | 3 | 1 3.0|
Osteopetrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5| |
| 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X | 11 |
Hemorrhage, Focal | 3 | 2 2.0|
Hemorrhage, Multifocal | 4 | 1 4.0|
Hydrocephalus | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + M + + + + + + M + + + + + + + + + + + + + + +| 46 |
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Diffuse | | 1 4.0|
Inflammation, Chronic, Focal | | 4 2.8|
Inflammation, Chronic Active, Focal | 3 3 2 3 3 3 | 10 2.6|
Submucosa, Dilatation, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | | 1 3.0|
Hemorrhage, Acute, Multifocal | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 2 | 2 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
Peribronchial, Hyperplasia, Lymphoid,| | |
Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 1 | 1 1.0|
Lumen, Foreign Body | 1 | 2 2.5|
Mucosa, Inflammation, Chronic | 1 | 2 2.5|
Mucosa, Inflammation, Chronic Active | 1 | 1 1.0|
Mucosa, Metaplasia, Focal | | 1 3.0|
Mucosa, Thrombosis, Multifocal | 3| 2 3.0|
Nasolacrimal Duct, Exudate | 1 1 1| 5 1.4|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 1 1 3 1 2 1 1 1 | 13 1.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 3 2 1| 5 2.2|
Olfactory Epithelium, Hyperplasia, | | |
Eosinophil | 1 | 2 1.5|
Respiratory Epithelium, Hyperplasia | 2 1 1 1 1 | 7 1.3|
Respiratory Epithelium, Hyperplasia, | | |
Multifocal | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 6| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 7| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 2| 5| |
| 1| 1| 4| 1| 1| 3| 1| 0| 0| 0| 3| 8| 1| 1| 1| 1| 1| 1| 0| 0| 5| 8| 0| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 4 3 2 3 4 4 2 3 3 3 3 2 2 4 2 4 2 3 2 3 3 1 2| 46 2.7|
Pigmentation, Diffuse | 3 4 3 3 2| 8 2.5|
Pigmentation, Multifocal | 1 2 2 1 | 11 1.6|
Cortex, Cyst | | 1 |
Cortex, Hyperplasia, Atypical, Focal | 3 2 | 2 2.5|
Cortex, Inflammation, Focal, | | |
Suppurative | 1 | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis, Multifocal | 2 2| 2 2.0|
Transitional Epithelium, | | |
Mineralization, Focal | 2 | 1 2.0|
Transitional Epithelium, | | |
Mineralization, Multifocal | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|
| 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic | |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M M + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 2 |
Angiectasis, Multifocal | 3 |
Basophilic Focus | X X X X X X|
Basophilic Focus, Multiple | X X X X X X X X |
Cytomegaly, Multifocal | |
Cytoplasmic Alteration, Focal | 2 |
Fatty Change, Focal | 2 2 |
Fatty Change, Multifocal | 1 |
Granuloma, Multifocal | 1 2 3 2 2 1|
Hemorrhage, Acute, Multifocal | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Multifocal, Nodular | 1 |
Inflammation, Chronic, Multifocal | 2 |
Mitotic Alteration | |
Mixed Cell Focus | X X|
Mixed Cell Focus, Two | X |
Necrosis, Multifocal | 1 2 2 |
Bile Duct, Hyperplasia, Multifocal | 1 3 |
Centrilobular, Fatty Change, Diffuse | 4 4 3 |
Centrilobular, Fatty Change, | |
Multifocal | |
Centrilobular, Necrosis, Diffuse | 2 |
Centrilobular, Necrosis, Multifocal | 1 |
Portal, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Mesentery | |
Artery, Inflammation, Multifocal, | |
Necrotizing | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|
| 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fat, Inflammation, Focal, Necrotizing| |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Granulomatous | |
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy, Multifocal | 2 2 3 2 2 |
Duct, Cyst, Multiple | |
__________________________________________________________________________|
Pharynx | |
Mucosa, Palate, Inflammation, | |
Chronic, Diffuse | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Inflammation, Chronic | |
Active, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic, Diffuse | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 1 3 2 2 2 1 1 3 2 2 1 2 2 1 1 2 2 2|
Artery, Inflammation, Chronic Active,| |
Focal | |
Atrium Left, Thrombosis | |
Epicardium, Inflammation, Chronic | |
Active, Focal | |
Myocardium, Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Capsule, Fibrosis, | |
Multifocal | |
Capsule, Accessory Adrenal Cortical | |
Nodule | X X X X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 3 2|
Atrophy | |
Congestion | 2 |
Degeneration, Diffuse, Fatty | 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|
| 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Fatty, Focal | 2 2 4 2 3 |
Degeneration, Fatty, Multifocal | 3 |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Hypertrophy, Focal | |
Hypertrophy, Multifocal | 3 |
Pigmentation, Diffuse, Hemosiderin | |
Pigmentation, Hemosiderin, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + M M + + M + + + +|
Angiectasis, Multifocal | 3 |
Hyperplasia, Focal | 1 2 2 2 |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 3 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Parathyroid Gland | M M + + + M + + + + + + + M M + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2|
Pars Distalis, Concretion | |
Pars Distalis, Cyst | 3 4 |
Pars Distalis, Hyperplasia, Focal | 3|
Pars Distalis, Hyperplasia | 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
Pars Nervosa, Pigmentation, Diffuse | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
C-Cell, Hyperplasia, Focal | 2 2 |
C-Cell, Hyperplasia, Multifocal | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M M M + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 2 |
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 2 |
Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|
| 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis, Focal | 2 |
Cyst | |
Dilatation | 2 |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia, Diffuse | 2 |
Epithelium, Hyperplasia, Focal | 4 |
Lumen, Hemorrhage | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Hyperplasia, Megakaryocyte | |
Hyperplasia | |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Re Cell | 2 |
Mediastinal, Pigmentation, Diffuse, | |
Hemosiderin | |
Pancreatic, Pigmentation, Hemosiderin| |
Renal, Hyperplasia, Plasma Cell | 3 |
Renal, Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 4 |
Hyperplasia, Re Cell | |
Artery, Inflammation, Chronic Active,| |
Focal | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M M + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Fibrosis, Multifocal | 3 |
Hematopoietic Cell Proliferation | 2 3 |
Pigmentation, Hemosiderin | 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + M M + + + + + + M + + + + + + + + + + + M M +|
Hyperplasia, Diffuse, Tubular | 3 2 3 2 3 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|
| 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ectasia, Diffuse | 3 |
Ectasia, Focal | 4 4 |
Ectasia, Multifocal | 3 1 3 2 3 2 2 3 |
Hyperplasia, Diffuse | 4 1 2 3 2 2 3 3 2 |
Hyperplasia, Focal | 4 |
Artery, Inflammation, Chronic Active,| |
Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | 4 |
Inflammation, Chronic Active, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Osteopetrosis | 4 3 3 |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Diffuse, Proliferative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X 4 X X X |
Hydrocephalus | 3 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M M + + + + + M + + + + M + + + + + + + + +|
Hyperplasia, Focal, Papillary | |
Inflammation, Acute, Diffuse | |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic Active, Focal | 2 1 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis, Focal | 1|
Inflammation, Chronic, Multifocal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Bronchiole, Alveolus, Inflammation, | |
Acute, Multifocal | 3 |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
Pleura, Inflammation, Multifocal, | |
Subacute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | |
Lumen, Foreign Body | |
Mucosa, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|
| 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Inflammation, Chronic | |
Mucosa, Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Exudate | 3 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 2 1 1 1 2 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Cyst | 2 1 2 1 1 1 1 1 |
Olfactory Epithelium, Erosion | 2 2 2 |
Olfactory Epithelium, Hyperplasia, | |
Eosinophil | 2 1 1 2 1 2 1|
Respiratory Epithelium, Cyst | 1 1 1 |
Respiratory Epithelium, Hyperplasia, | |
Eosinophil | 1 2 1 |
Respiratory Epithelium, Hyperplasia | 1 2 3 1 2 3 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 4 |
Bilateral, Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 2 3 2 2 4 2 1 3 1 1 3 1 3 3 1 3 3 3 1 4 2|
Pigmentation, Diffuse | 3 2 2 3 2 2 |
Pigmentation, Multifocal | 3 1 2 |
Bilateral, Hydronephrosis | 2 |
Cortex, Hyperplasia, Atypical, Focal | 1 |
Cortex, Mineralization, Multifocal | |
Corticomedullary Junction, | |
Mineralization, Multifocal | 1 |
Pelvis, Inflammation, Diffuse, | |
Suppurative | 3 |
Transitional Epithelium, Hyperplasia | 2 |
Transitional Epithelium, | |
Mineralization, Focal | |
Transitional Epithelium, | |
Mineralization, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 4| 1| 3| 3| 3| 3| 3| 5| 0| 1| 3| 8| 9| 3| 9| 3| 3| 3| 8| 0| 3| 3|
| 0| 1| 1| 4| 4| 1| 1| 1| 0| 0| 6| 6| 4| 1| 1| 9| 1| 7| 1| 1| 0| 3| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Ectasia | 3 4 |
Inflammation, Chronic, Diffuse | 2 |
Artery, Inflammation, Chronic Active,| |
Multifocal | |
Transitional Epithelium, Hyperplasia,| |
Focal | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| |
DAY ON TEST | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2| |
| 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + M + M +| 46 |
Inflammation, Chronic | 1 | 1 1.0|
Parasite Metazoan | X X X X| 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X X X | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X| 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Muscularis, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 3 2.3|
Angiectasis, Multifocal | | 1 3.0|
Basophilic Focus | X | 7 |
Basophilic Focus, Multiple | X X X X X X| 14 |
Cytomegaly, Multifocal | 1 | 1 1.0|
Cytoplasmic Alteration, Focal | | 1 2.0|
Fatty Change, Focal | | 2 2.0|
Fatty Change, Multifocal | 1 2 1 | 4 1.3|
Granuloma, Multifocal | 1 2 1 1 2 1 1 4 | 14 1.7|
Hemorrhage, Acute, Multifocal | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 6 |
Hyperplasia, Multifocal, Nodular | 3 | 2 2.0|
Inflammation, Chronic, Multifocal | | 1 2.0|
Mitotic Alteration | 3 | 1 3.0|
Mixed Cell Focus | X | 3 |
Mixed Cell Focus, Two | | 1 |
Necrosis, Multifocal | 2 3 | 5 2.0|
Bile Duct, Hyperplasia, Multifocal | 2 3 2 2 | 6 2.2|
Centrilobular, Fatty Change, Diffuse | 4 3 | 5 3.6|
Centrilobular, Fatty Change, | | |
Multifocal | 2 | 1 2.0|
Centrilobular, Necrosis, Diffuse | | 1 2.0|
Centrilobular, Necrosis, Multifocal | 2 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| |
DAY ON TEST | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2| |
| 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Portal, Inflammation, Chronic, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 5 |
Artery, Inflammation, Multifocal, | | |
Necrotizing | 4 | 1 4.0|
Fat, Inflammation, Focal, Necrotizing| 4 | 1 4.0|
Fat, Necrosis, Focal | 3 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Focal, Granulomatous | 1 | 1 1.0|
Acinus, Atrophy, Focal | 2 | 2 2.0|
Acinus, Atrophy, Multifocal | 2 2 3 | 8 2.3|
Duct, Cyst, Multiple | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Mucosa, Palate, Inflammation, | | |
Chronic, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Parotid Gland, Inflammation, Chronic | | |
Active, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic, Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 3 2 2 2 2 1 1 3 2 2 2 2 1 1 2 1| 40 1.9|
Artery, Inflammation, Chronic Active,| | |
Focal | 3 | 1 3.0|
Atrium Left, Thrombosis | 3 2 | 2 2.5|
Epicardium, Inflammation, Chronic | | |
Active, Focal | 2 | 1 2.0|
Myocardium, Degeneration, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| |
DAY ON TEST | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2| |
| 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Capsule, Fibrosis, | | |
Multifocal | 2 | 1 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | 3 3 | 4 2.8|
Atrophy | 2 | 1 2.0|
Congestion | 2 | 2 2.0|
Degeneration, Diffuse, Fatty | | 1 3.0|
Degeneration, Fatty, Focal | 3 1 4 | 8 2.6|
Degeneration, Fatty, Multifocal | | 1 3.0|
Hyperplasia, Focal | 3 1| 2 2.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
Hypertrophy, Focal | 2 | 1 2.0|
Hypertrophy, Multifocal | | 1 3.0|
Pigmentation, Diffuse, Hemosiderin | 2 | 1 2.0|
Pigmentation, Hemosiderin, Multifocal| 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 45 |
Angiectasis, Multifocal | | 1 3.0|
Hyperplasia, Focal | 2 | 5 1.8|
Hyperplasia, Multifocal | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 | 4 2.0|
Hypertrophy, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + M + + + + + + + M| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | 3 | 2 2.5|
Pars Distalis, Concretion | 2 | 1 2.0|
Pars Distalis, Cyst | X 2 2 3 2 X 2 3 | 10 2.6|
Pars Distalis, Hyperplasia, Focal | 2 | 2 2.5|
Pars Distalis, Hyperplasia | | 1 3.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
Pars Nervosa, Pigmentation, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
C-Cell, Hyperplasia, Focal | 2 | 3 2.0|
C-Cell, Hyperplasia, Multifocal | 1 2 2 2 2 | 7 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| |
DAY ON TEST | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2| |
| 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 46 |
Atrophy | 3 | 1 3.0|
Ectasia | 3 3 3 | 4 2.8|
Hyperplasia | 4 3 4 | 3 3.7|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Inflammation, Granulomatous | 2 2 3| 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Diffuse | | 1 2.0|
Cyst | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomyosis, Focal | | 1 2.0|
Cyst | 1 | 1 1.0|
Dilatation | 3 | 2 2.5|
Inflammation, Chronic Active | 4 | 1 4.0|
Epithelium, Hyperplasia, Diffuse | | 1 2.0|
Epithelium, Hyperplasia, Focal | | 1 4.0|
Lumen, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
Hyperplasia, Megakaryocyte | 3 | 1 3.0|
Hyperplasia | 2 3 | 2 2.5|
Myeloid Cell, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hemorrhage | 3 3 3 | 3 3.0|
Mediastinal, Hyperplasia, Re Cell | | 1 2.0|
Mediastinal, Pigmentation, Diffuse, | | |
Hemosiderin | 3 | 1 3.0|
Pancreatic, Pigmentation, Hemosiderin| 3 | 1 3.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
Renal, Hyperplasia, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + M + + + + + + + + + + + + +| 47 |
Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| |
DAY ON TEST | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2| |
| 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 2 3 3 | 5 3.0|
Hyperplasia, Re Cell | 2 | 1 2.0|
Artery, Inflammation, Chronic Active,| | |
Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + M + + + + + + + + + +| 46 |
Hemorrhage | 3 | 2 3.0|
Hyperplasia, Re Cell | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 | 2 2.5|
Fibrosis, Multifocal | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 2 | 5 2.2|
Pigmentation, Hemosiderin | 2 2 2 3 2 3 2 | 15 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M M + + + M + + M + + + + + M M M M| 37 |
Hyperplasia, Diffuse, Tubular | 2 3 2 2 | 14 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia, Diffuse | | 1 3.0|
Ectasia, Focal | | 2 4.0|
Ectasia, Multifocal | 2 3 2 2 2 2 1 | 15 2.2|
Hyperplasia, Diffuse | 3 2 3 4 2 2 | 15 2.5|
Hyperplasia, Focal | 2 | 2 3.0|
Artery, Inflammation, Chronic Active,| | |
Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Squamous | | 1 4.0|
Inflammation, Chronic Active, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 2 | 2 2.0|
Osteopetrosis | 2 3 | 5 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Diffuse, Proliferative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X | 16 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| |
DAY ON TEST | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2| |
| 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hydrocephalus | 2 2 | 5 2.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + + M + M + + + + + + + M + + M + M +| 40 |
Hyperplasia, Focal, Papillary | 2 | 1 2.0|
Inflammation, Acute, Diffuse | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 2 | 3 1.7|
Inflammation, Chronic Active, Focal | | 4 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis, Focal | | 1 1.0|
Inflammation, Chronic, Multifocal | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
Bronchiole, Alveolus, Inflammation, | | |
Acute, Multifocal | | 1 3.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 3 | 1 3.0|
Pleura, Inflammation, Multifocal, | | |
Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 1 2 | 2 1.5|
Lumen, Foreign Body | 1 | 1 1.0|
Mucosa, Inflammation, Acute | 4 | 1 4.0|
Mucosa, Inflammation, Chronic | 1 | 1 1.0|
Mucosa, Inflammation, Chronic Active | 1 1 1 | 4 1.0|
Nasolacrimal Duct, Exudate | 2 1 | 4 1.8|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 2 2 1 1 1 1 | 16 1.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 1 3 2 | 4 2.3|
Olfactory Epithelium, Atrophy | 1 1 1 | 3 1.0|
Olfactory Epithelium, Cyst | 1 1 2 1 1 | 13 1.2|
Olfactory Epithelium, Erosion | 1 | 4 1.8|
Olfactory Epithelium, Hyperplasia, | | |
Eosinophil | 2 1 1 3 1 2 3 1 1 1 3 1 1 2| 21 1.6|
Respiratory Epithelium, Cyst | 1 1 1 1 1 1 1 | 10 1.0|
Respiratory Epithelium, Hyperplasia, | | |
Eosinophil | | 3 1.3|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 3 1 1 2 | 16 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 4| 6| 7| 5| 7| 5| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| |
DAY ON TEST | 8| 3| 2| 4| 1| 3| 1| 2| 7| 2| 7| 3| 3| 3| 2| 0| 2| 2| 8| 2| 2| 2| 2| 0| 2| |
| 0| 0| 9| 6| 8| 4| 4| 9| 6| 8| 6| 7| 0| 0| 9| 9| 6| 9| 2| 8| 8| 6| 8| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cataract | | 1 4.0|
Bilateral, Cataract | | 1 3.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Inflammation, Chronic, Multifocal | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 2 | 1 2.0|
Nephropathy, Chronic | 4 3 1 1 3 3 3 4 1 2 2 1 2 2 4 2 3 2 2 2 2 2| 43 2.3|
Pigmentation, Diffuse | 3 3 3 3 2 | 11 2.5|
Pigmentation, Multifocal | 2 2 2 | 6 2.0|
Bilateral, Hydronephrosis | | 1 2.0|
Cortex, Hyperplasia, Atypical, Focal | | 1 1.0|
Cortex, Mineralization, Multifocal | 3 | 1 3.0|
Corticomedullary Junction, | | |
Mineralization, Multifocal | | 1 1.0|
Pelvis, Inflammation, Diffuse, | | |
Suppurative | | 1 3.0|
Transitional Epithelium, Hyperplasia | 1 2 | 3 1.7|
Transitional Epithelium, | | |
Mineralization, Focal | 1 | 1 1.0|
Transitional Epithelium, | | |
Mineralization, Multifocal | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + M + + + + + + + + + + + + + + + +| 46 |
Ectasia | | 2 3.5|
Inflammation, Chronic, Diffuse | | 1 2.0|
Artery, Inflammation, Chronic Active,| | |
Multifocal | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|
| 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + M + M |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Angiectasis, Multifocal | 3 |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X X X X |
Congestion, Acute, Multifocal | 3 |
Fatty Change, Diffuse | |
Fatty Change, Multifocal | 2 |
Granuloma, Multifocal | 2 2 2 |
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | X |
Hyperplasia, Focal, Nodular | 2 |
Mitotic Alteration | 2 |
Necrosis, Focal | 1 |
Necrosis, Multifocal | 2 |
Pigmentation, Multifocal | |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 |
Centrilobular, Atrophy, Multifocal | 3 |
Centrilobular, Degeneration, Diffuse | 2 2 |
Centrilobular, Degeneration, | |
Multifocal | 2 |
Centrilobular, Fatty Change, Diffuse | 3 3 |
Periportal, Fatty Change, Multifocal | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + +|
Acinus, Atrophy, Multifocal | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|
| 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + |
Cardiomyopathy | 2 |
Atrium Left, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
Angiectasis, Multifocal | 2|
Congestion | 3 |
Degeneration, Fatty, Focal | |
Degeneration, Fatty, Multifocal | 2 |
Hyperplasia, Multifocal | |
Hypertrophy, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Angiectasis, | |
Multifocal | 2 |
Pars Distalis, Cyst | 1 3 3 4 4 |
Pars Distalis, Cyst, Multiple | 4 |
Pars Distalis, Hyperplasia, Focal | 2|
Pars Distalis, Hyperplasia | 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
Developmental Malformation | |
C-Cell, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Necrosis, Acute | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M M + + + |
Abscess | 3 |
Atrophy | 3 |
Ectasia | 3 |
Hyperplasia | 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|
| 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + |
Cyst | X 3 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + |
Dilatation | 3 |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Pancreatic, Hemorrhage | |
Pancreatic, Inflammation, Acute | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + |
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + |
Hemorrhage | 2 2 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Fibrosis, Focal | 4 |
Metaplasia, Focal, Osseous | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + M |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M |
Ectasia, Diffuse | 3 |
Ectasia, Multifocal | 1 2 2 2 3 3 2 |
Galactocele | 4 |
Hyperplasia, Diffuse | 2 2 3 2 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Skin | + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
Compression | |
Hemorrhage, Multifocal | 3 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 0| 3| 3| 3| 4| 9| 3| 3| 9| 5| 1| 3| 9| 3| 3| 3| 3| 0| 9| 3| 3| 2| 3| 3|
| 1| 1| 1| 1| 1| 8| 5| 1| 1| 9| 9| 4| 1| 3| 1| 1| 1| 1| 3| 6| 0| 0| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Granuloma, Multifocal | 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 2 1 |
Mucosa, Inflammation, Chronic | |
Mucosa, Inflammation, Chronic Active | 1 1 |
Mucosa, Thrombosis, Multifocal | 4 4 1 |
Nasolacrimal Duct, Exudate | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 3 2 1 2 1 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Cyst | 1 1 1 1 1 |
Olfactory Epithelium, Erosion | 1 1 |
Olfactory Epithelium, Exudate | |
Olfactory Epithelium, Hyperplasia, | |
Eosinophil | 2 1 1 1 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Cyst | 1 1 1 |
Respiratory Epithelium, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + M + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Bilateral, Cataract | |
Bilateral, Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Nephropathy, Chronic | 4 2 |
Pigmentation, Diffuse | 3 |
Pigmentation, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2| |
| 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + M | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 10 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M + | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 33 |
Angiectasis, Multifocal | 3 | 2 3.0|
Basophilic Focus | X X | 3 |
Basophilic Focus, Multiple | X X | 9 |
Congestion, Acute, Multifocal | 2 2 | 3 2.3|
Fatty Change, Diffuse | 4 | 1 4.0|
Fatty Change, Multifocal | | 1 2.0|
Granuloma, Multifocal | 2 1 3 | 6 2.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Hyperplasia, Focal, Nodular | 2 | 2 2.0|
Mitotic Alteration | | 1 2.0|
Necrosis, Focal | | 1 1.0|
Necrosis, Multifocal | | 1 2.0|
Pigmentation, Multifocal | 2 | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 | 7 2.0|
Centrilobular, Atrophy, Multifocal | | 1 3.0|
Centrilobular, Degeneration, Diffuse | 2 3 | 4 2.3|
Centrilobular, Degeneration, | | |
Multifocal | | 1 2.0|
Centrilobular, Fatty Change, Diffuse | 4 | 3 3.3|
Periportal, Fatty Change, Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 13 |
Acinus, Atrophy, Multifocal | 1 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 9 |
__________________________________________________________________________|____________|
Stomach | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + +| 11 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2| |
| 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + +| 11 |
Cyst Epithelial Inclusion | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 10 |
Cardiomyopathy | 1 1 1 | 4 1.3|
Atrium Left, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 14 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 14 |
Angiectasis, Multifocal | 3 2 | 3 2.3|
Congestion | | 1 3.0|
Degeneration, Fatty, Focal | 4 | 1 4.0|
Degeneration, Fatty, Multifocal | | 1 2.0|
Hyperplasia, Multifocal | 3 | 1 3.0|
Hypertrophy, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 14 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| 43 |
Pars Distalis, Angiectasis, Focal | | 1 2.0|
Pars Distalis, Angiectasis, | | |
Multifocal | 2 3| 3 2.3|
Pars Distalis, Cyst | 2 2 2 2 3 | 10 2.6|
Pars Distalis, Cyst, Multiple | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 2 | 2 2.0|
Pars Distalis, Hyperplasia | | 1 3.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 10 |
Developmental Malformation | X | 1 |
C-Cell, Hyperplasia, Multifocal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2| |
| 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Necrosis, Acute | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + M | 11 |
Abscess | | 1 3.0|
Atrophy | | 1 3.0|
Ectasia | 2 | 2 2.5|
Hyperplasia | | 1 4.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 18 |
Cyst | 4 4 | 5 3.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 18 |
Dilatation | 2 4 | 3 3.0|
Lumen, Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 17 |
Pancreatic, Hemorrhage | 2 | 1 2.0|
Pancreatic, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 11 |
Hyperplasia, Re Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 12 |
Hemorrhage | | 3 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 19 |
Fibrosis, Focal | | 1 4.0|
Metaplasia, Focal, Osseous | 3 | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M M + + | 6 |
Ectopic Parathyroid Gland | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 29 |
Ectasia, Diffuse | 2 2 | 3 2.3|
Ectasia, Multifocal | 4 2 4 | 10 2.5|
Galactocele | | 1 4.0|
Hyperplasia, Diffuse | 1 2 2 2 3 2| 11 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2| |
| 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 11 |
Compression | X | 1 |
Hemorrhage, Multifocal | | 1 3.0|
Hydrocephalus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M | 6 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma, Multifocal | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 2 | 5 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 1 | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 1| 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumen, Exudate | 3 1 | 4 1.8|
Mucosa, Inflammation, Chronic | 1 1| 2 1.0|
Mucosa, Inflammation, Chronic Active | 3 1 | 4 1.5|
Mucosa, Thrombosis, Multifocal | 3 | 4 3.0|
Nasolacrimal Duct, Exudate | 2 1 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 1 1 1 1 1 2 3 2 1 1 | 17 1.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 3.0|
Olfactory Epithelium, Atrophy | 1 1 | 2 1.0|
Olfactory Epithelium, Cyst | | 5 1.0|
Olfactory Epithelium, Erosion | 2 | 3 1.3|
Olfactory Epithelium, Exudate | 1 | 1 1.0|
Olfactory Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 5| 7| 5| 6| 6| 7| 7| |
DAY ON TEST | 2| 3| 6| 2| 2| 2| 0| 2| 2| 0| 2| 7| 3| 3| 2| 0| 6| 2| 2| 2| 8| 3| 3| 2| 2| |
| 4| 0| 1| 9| 9| 4| 7| 8| 8| 9| 8| 5| 0| 0| 9| 7| 0| 9| 6| 8| 3| 7| 7| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Eosinophil | 1 1 3 3 2 | 9 1.7|
Olfactory Epithelium, Metaplasia | 3 | 1 3.0|
Respiratory Epithelium, Cyst | 1 1 1 | 6 1.0|
Respiratory Epithelium, Hyperplasia | 1 3 2 1 1 1 1 1 1 | 19 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Bilateral, Cataract | 4 | 1 4.0|
Bilateral, Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 14 |
Nephropathy, Chronic | 4 1 4 3 | 6 3.0|
Pigmentation, Diffuse | 2 | 2 2.5|
Pigmentation, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|
| 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M M + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + M M + + + + + + M M + + + + +|
Parasite Metazoan | X |
Artery, Submucosa, Inflammation, | |
Chronic Active, Multifocal | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Chronic, Diffuse | |
Ulcer, Two | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Angiectasis, Multifocal | 2 2|
Basophilic Focus | X |
Basophilic Focus, Multiple | |
Cytoplasmic Alteration, Focal | 2 3 |
Degeneration, Ballooning, Focal | 2 |
Eosinophilic Focus | X|
Eosinophilic Focus, Multiple | X |
Fatty Change, Diffuse | 1 |
Fatty Change, Focal | 1 |
Fatty Change, Multifocal | |
Granuloma, Multifocal | 3 1 1 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hemorrhage, Multifocal | 3 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Multifocal, Nodular | |
Necrosis, Multifocal | 3 2 3 4 |
Thrombosis, Two | X |
Bile Duct, Fibrosis, Multifocal | 2 |
Bile Duct, Hyperplasia, Multifocal | 2 2 3 1 4 4 3 2 2 1 3 3 2 |
Centrilobular, Congestion, Diffuse | 3 |
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Fatty Change, Diffuse | 3 4 3 3 |
Centrilobular, Fatty Change, | |
Multifocal | |
Centrilobular, Necrosis, Diffuse | 1 2 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|
| 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Centrilobular, Necrosis, Multifocal | |
Periportal, Fatty Change, Diffuse | |
Portal, Inflammation, Chronic, | |
Multifocal | |
Portal, Inflammation, Chronic Active,| |
Multifocal | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage, Acute, Multifocal | 4 |
Artery, Inflammation, Chronic, | |
Multifocal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + M + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Acinus, Atrophy, Diffuse | 2 |
Acinus, Atrophy, Focal | 2 2 2|
Acinus, Atrophy, Multifocal | 2 2 1 4 2 3 3 4 |
Acinus, Hyperplasia, Multifocal | |
Artery, Inflammation, Chronic Active,| |
Multifocal | 3 |
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active,| |
Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 1 4 3 |
Ulcer | 3 4 4 |
Epithelium, Hyperplasia | 2 3 3 |
Submucosa, Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
Mineralization, Multifocal | 2 |
Ulcer, Acute | 3 |
__________________________________________________________________________|
Tooth | + + |
Pulp, Angiectasis | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 3 2 2 2 2 2 3 2 2 3 2 2 2 3 1 2 2 2 2 2|
Atrium Left, Thrombosis | 3 3 |
Endocardium, Atrium, Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|
| 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Valve, Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Degeneration, Diffuse, Fatty | 2 1 1 2 2 3 |
Degeneration, Fatty, Focal | 2 2 2 2 3|
Degeneration, Fatty, Multifocal | 2 2 |
Hyperplasia, Focal | 3 |
Hyperplasia, Multifocal | 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Hyperplasia, Focal | 2 2 2 3 3 |
Hyperplasia, Multifocal | 2 2 2 1 3 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + +|
Atrophy, Diffuse | |
Hyperplasia, Focal | |
Hyperplasia | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Diffuse, | |
Eosinophil | 3 |
Pars Distalis, Hyperplasia, Focal | 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 2 2 |
Pars Distalis, Pigmentation, Focal | 3 |
Pars Intermedia, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Mineralization, Multifocal | |
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | 4 |
Follicular Cell, Degeneration, | |
Multifocal | 1 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|
| 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation, Multifocal | 2 |
Granuloma Sperm, Single | |
Inflammation, Focal, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + M + +|
Atrophy, Diffuse | |
Ectasia | 2 |
Fibrosis, Diffuse | |
Inflammation, Chronic Active | 2 1 |
Inflammation, Diffuse, Granulomatous | 2 |
Inflammation, Focal, Granulomatous | 2 2 |
Inflammation, Focal, Suppurative | 2 |
Inflammation, Granulomatous, | |
Multifocal | 3 2 2 2 3 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 2 |
Hyperplasia, Multifocal | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 4 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + M + + + + + + + + M + + M + +|
Atrophy, Diffuse | 2 |
Inflammation, Diffuse, Subacute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 |
Mineralization, Multifocal | |
Arteriole, Inflammation | 2 1 3 3 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 1 1 1 3 |
Seminiferous Tubule, Degeneration | |
Serosa, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 |
Metaplasia, Osseous | |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | 3 |
Lumbar, Inflammation, Granulomatous, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|
| 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Re Cell | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 4 |
Hyperplasia, Re Cell | 3 |
Inflammation, Focal, Subacute | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + M + + + M + + + M + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Fibrosis, Multifocal | 2 2 |
Hematopoietic Cell Proliferation | 2 1 4 |
Necrosis, Coagulative, Focal | 3 |
Pigmentation, Hemosiderin | 2 2 |
Capsule, Fibrosis, Multifocal | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + M + M + + + + + + + M M +|
Hemorrhage | |
Hyperplasia, Tubular | 2 2 2 3 |
Artery, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + M M + +|
Ectasia, Diffuse | 3 3 3 4 2 2|
Ectasia, Multifocal | 2 2 4 3 3 3 2 1 4 2 4 |
Hyperplasia, Diffuse | 3 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
Inflammation, Proliferative | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Hyperplasia, Squamous | |
Inflammation, Chronic, Focal | |
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic Active, | |
Focal | |
Subcutaneous Tissue, Hemorrhage, | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|
| 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Chronic, Focal | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Developmental Malformation | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 1 4 3 X X 2|
Hemorrhage, Focal | 4 3 |
Hemorrhage, Multifocal | 4 |
Hydrocephalus | 4 2 |
Thalamus, Gliosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + M + + + + M + + + + M + + M M + + M + +|
Inflammation, Chronic Active, Focal | 3 2 1 2 4 |
Inflammation, Focal, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema, Focal | |
Hemorrhage, Multifocal, Subacute | 3 |
Bronchus, Epithelium, Hyperplasia, | |
Focal | |
Interstitium, Inflammation, Chronic, | |
Focal | 1 |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
Vein, Mineralization, Multifocal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + +|
Lumen, Exudate | 2 1 |
Lumen, Foreign Body | 2 |
Mucosa, Inflammation, Chronic | 1 1 2 |
Mucosa, Inflammation, Chronic Active | 2 2 |
Mucosa, Thrombosis, Multifocal | 4 2 3 |
Nasolacrimal Duct, Exudate | |
Nasolacrimal Duct, Hyperplasia | 2|
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 4 2 3 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Hyperplasia, | |
Eosinophil | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 5| 0| 7| 6| 6| 6| 5| 7| 7| 3| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 3| 0| 2| 2| 2| 3| 2| 5| 1| 8| 2| 2| 1| 2| 0| 7| 1| 2| 2| 2| 5| 3|
| 9| 8| 8| 3| 6| 8| 8| 9| 8| 0| 7| 4| 3| 1| 3| 1| 9| 0| 1| 1| 9| 9| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Cyst | |
Respiratory Epithelium, Hyperplasia, | |
Eosinophil | 1 2 |
Respiratory Epithelium, Hyperplasia | 1 2 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active,| |
Focal | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Choroid, Left, Hemorrhage | 4 |
Retina, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 4 3 3 2 4 4 4 1 2 3 3 1 4 3 4 4 4 3 4 2 3 4|
Pigmentation, Diffuse | 3 |
Pigmentation, Multifocal | 2 |
Cortex, Cyst | 2 |
Cortex, Hyperplasia, Atypical | |
Transitional Epithelium, Hyperplasia | 3 |
Transitional Epithelium, | |
Mineralization | 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Inflammation, Chronic Active, Focal | 2 |
Lumen, Calculus Micro Observation | |
Only, Single | X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3| |
| 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + A + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + + + +| 43 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M M M + + + M + + + + + + M + + + + + + + + +| 36 |
Parasite Metazoan | X | 2 |
Artery, Submucosa, Inflammation, | | |
Chronic Active, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + A + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Inflammation, Chronic, Diffuse | 2 | 1 2.0|
Ulcer, Two | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Focal | 2 | 3 2.0|
Angiectasis, Multifocal | 2 | 3 2.0|
Basophilic Focus | | 1 |
Basophilic Focus, Multiple | X | 1 |
Cytoplasmic Alteration, Focal | | 2 2.5|
Degeneration, Ballooning, Focal | 2 2 | 3 2.0|
Eosinophilic Focus | | 1 |
Eosinophilic Focus, Multiple | | 1 |
Fatty Change, Diffuse | | 1 1.0|
Fatty Change, Focal | 1 | 2 1.0|
Fatty Change, Multifocal | 2 | 1 2.0|
Granuloma, Multifocal | | 4 1.5|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Hemorrhage, Multifocal | 3 | 2 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
Hyperplasia, Multifocal, Nodular | 4 | 1 4.0|
Necrosis, Multifocal | 2 2 1 3 2 2 1 2 | 12 2.3|
Thrombosis, Two | | 1 |
Bile Duct, Fibrosis, Multifocal | 3 | 2 2.5|
Bile Duct, Hyperplasia, Multifocal | 4 3 1 4 2 4 3 3 1 3 2 3 4 3 3 2 1 2 3| 32 2.6|
Centrilobular, Congestion, Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3| |
| 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Centrilobular, Degeneration, Diffuse | 2 3 | 2 2.5|
Centrilobular, Fatty Change, Diffuse | 4 3 4 4 4 2 4 | 11 3.5|
Centrilobular, Fatty Change, | | |
Multifocal | 3 | 1 3.0|
Centrilobular, Necrosis, Diffuse | 3 3 | 5 2.4|
Centrilobular, Necrosis, Multifocal | 2 | 1 2.0|
Periportal, Fatty Change, Diffuse | 3 | 1 3.0|
Portal, Inflammation, Chronic, | | |
Multifocal | 1 | 1 1.0|
Portal, Inflammation, Chronic Active,| | |
Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + +| 8 |
Hemorrhage, Acute, Multifocal | | 1 4.0|
Artery, Inflammation, Chronic, | | |
Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + A + + + + + M + + + + +| 46 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 2 1.0|
Acinus, Atrophy, Diffuse | 4 4 | 3 3.3|
Acinus, Atrophy, Focal | 2 1 | 5 1.8|
Acinus, Atrophy, Multifocal | 2 1 1 4 3 2 2 2 1 2| 18 2.3|
Acinus, Hyperplasia, Multifocal | 1 | 1 1.0|
Artery, Inflammation, Chronic Active,| | |
Multifocal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Artery, Inflammation, Chronic Active,| | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 5 2.8|
Ulcer | | 3 3.7|
Epithelium, Hyperplasia | 3 3 3 | 6 2.8|
Submucosa, Inflammation, Subacute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst, Multiple | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3| |
| 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization, Multifocal | | 1 2.0|
Ulcer, Acute | 2 | 2 2.5|
__________________________________________________________________________|____________|
Tooth | | 2 |
Pulp, Angiectasis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 4 2 3 4 1 1 1 2 2 1 3 2 4 3 2 2 3 2 2 1| 42 2.2|
Atrium Left, Thrombosis | 3 2 | 4 2.8|
Endocardium, Atrium, Fibrosis, Focal | 2 | 1 2.0|
Valve, Fibrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X X X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration, Focal | 2 | 1 2.0|
Degeneration, Diffuse, Fatty | 2 3 3 2 2 3 3 | 13 2.2|
Degeneration, Fatty, Focal | 2 | 6 2.2|
Degeneration, Fatty, Multifocal | 1 | 3 1.7|
Hyperplasia, Focal | 2 1 2 | 4 2.0|
Hyperplasia, Multifocal | | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Focal | 2 | 1 2.0|
Hyperplasia, Focal | 2 2 2| 8 2.3|
Hyperplasia, Multifocal | 2 1 2 3 | 10 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + M + + + + +| 46 |
Atrophy, Diffuse | 4 | 1 4.0|
Hyperplasia, Focal | 3 2 | 2 2.5|
Hyperplasia | 3 | 1 3.0|
Hyperplasia, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + M + + + +| 45 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 2 2.5|
Pars Distalis, Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Diffuse, | | |
Eosinophil | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3| |
| 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | 2 | 2 2.5|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 2 | 5 2.0|
Pars Distalis, Pigmentation, Focal | | 1 3.0|
Pars Intermedia, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Mineralization, Multifocal | 2 | 1 2.0|
C-Cell, Hyperplasia, Focal | 3 3 2 2 | 4 2.5|
C-Cell, Hyperplasia, Multifocal | 2 2 2 | 4 2.5|
Follicular Cell, Degeneration, | | |
Multifocal | | 1 1.0|
Follicular Cell, Hyperplasia, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Dilatation, Multifocal | 2 | 2 2.0|
Granuloma Sperm, Single | 4 | 1 4.0|
Inflammation, Focal, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 46 |
Atrophy, Diffuse | 3 | 1 3.0|
Ectasia | 3 | 2 2.5|
Fibrosis, Diffuse | 3 4 | 2 3.5|
Inflammation, Chronic Active | 3 3 | 4 2.3|
Inflammation, Diffuse, Granulomatous | | 1 2.0|
Inflammation, Focal, Granulomatous | 2 2 | 4 2.0|
Inflammation, Focal, Suppurative | | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 2 2 2 2 3 3 3 2 2 2 2| 18 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 1 | 5 1.2|
Hyperplasia, Multifocal | 2 1 | 3 1.7|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 2 2 | 8 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + M + + + + + + M + + + + + M + + + + +| 41 |
Atrophy, Diffuse | 2 3| 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3| |
| 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Diffuse, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization, Focal | | 1 1.0|
Mineralization, Multifocal | 2 | 1 2.0|
Arteriole, Inflammation | 3 3 | 6 2.5|
Interstitial Cell, Hyperplasia | 1 1 | 2 1.0|
Seminiferous Tubule, Atrophy | 2 3 1 3 3 3 4 3 | 13 2.5|
Seminiferous Tubule, Degeneration | 2 3 | 2 2.5|
Serosa, Necrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 4 3 4 | 8 3.1|
Metaplasia, Osseous | 2 | 1 2.0|
Myelofibrosis | 3 | 1 3.0|
Myeloid Cell, Hyperplasia | 3 4 3 | 4 3.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Focal, Suppurative | | 1 3.0|
Lumbar, Inflammation, Granulomatous, | | |
Multifocal | | 1 3.0|
Mediastinal, Hemorrhage | 3 4 | 2 3.5|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Re Cell | 3 | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 3 2 | 2 2.5|
Pancreatic, Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + M + + + + M + + + + + + + M + + + + +| 44 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Hyperplasia, Plasma Cell | 3 | 2 3.5|
Hyperplasia, Re Cell | | 1 3.0|
Inflammation, Focal, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| 44 |
Depletion Lymphoid | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Hyperplasia, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis, Focal | 3 | 1 3.0|
Fibrosis, Multifocal | | 2 2.0|
Hematopoietic Cell Proliferation | 3 | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3| |
| 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis, Coagulative, Focal | | 1 3.0|
Pigmentation, Hemosiderin | 2 | 3 2.0|
Capsule, Fibrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + + + + + + + M M + + M + M + + +| 38 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Tubular | 2 3 3 2 | 8 2.4|
Artery, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M + + M + + + + M M + + + + + + M + M + + +| 38 |
Ectasia, Diffuse | 3 3 1 | 9 2.7|
Ectasia, Multifocal | 2 2 2 | 14 2.6|
Hyperplasia, Diffuse | 3 | 3 2.7|
Inflammation, Chronic Active, | | |
Multifocal | 2 | 2 2.0|
Inflammation, Proliferative | | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 3 | 1 3.0|
Hyperplasia, Squamous | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Artery, Subcutaneous Tissue, | | |
Inflammation, Chronic Active, | | |
Focal | 2 | 1 2.0|
Subcutaneous Tissue, Hemorrhage, | | |
Chronic, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sternum, Developmental Malformation | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | X X X 2 | 11 2.6|
Hemorrhage, Focal | 2 1 | 4 2.5|
Hemorrhage, Multifocal | | 1 4.0|
Hydrocephalus | 3 | 3 3.0|
Thalamus, Gliosis, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3| |
| 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + M + + + M + + + M + + M + + + + M + + + + +| 37 |
Inflammation, Chronic Active, Focal | 3 2 | 7 2.4|
Inflammation, Focal, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema, Focal | 4 | 1 4.0|
Hemorrhage, Multifocal, Subacute | | 1 3.0|
Bronchus, Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 4 4| 2 4.0|
Vein, Mineralization, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lumen, Exudate | | 2 1.5|
Lumen, Foreign Body | 1 | 2 1.5|
Mucosa, Inflammation, Chronic | 1 | 4 1.3|
Mucosa, Inflammation, Chronic Active | | 2 2.0|
Mucosa, Thrombosis, Multifocal | 1 2 | 5 2.4|
Nasolacrimal Duct, Exudate | 2 | 1 2.0|
Nasolacrimal Duct, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 2 2 2 2 1 | 14 1.9|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 3 2 2 3 | 5 2.4|
Olfactory Epithelium, Atrophy | 1 1 | 2 1.0|
Olfactory Epithelium, Hyperplasia, | | |
Eosinophil | | 1 2.0|
Respiratory Epithelium, Cyst | 2 1 | 2 1.5|
Respiratory Epithelium, Hyperplasia, | | |
Eosinophil | 2 1 | 4 1.5|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 8 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Artery, Inflammation, Chronic Active,| | |
Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 7| 7| 5| 6| 6| 7| 5| 5| 5| 5| 7| 7| 7| 7| 6| 4| 7| 6| 7| 6| 7| |
DAY ON TEST | 0| 1| 7| 4| 2| 2| 3| 2| 5| 3| 5| 9| 5| 2| 3| 2| 2| 2| 9| 9| 2| 4| 3| 9| 3| |
| 7| 3| 3| 3| 9| 9| 2| 3| 8| 0| 7| 9| 3| 5| 0| 9| 9| 9| 3| 2| 1| 7| 0| 7| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Choroid, Left, Hemorrhage | | 1 4.0|
Retina, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 1 3 3 3 4 4 1 3 2 4 2 4 2 4 3 4 3 3 4 2 3 3 3| 46 3.1|
Pigmentation, Diffuse | 2 4 2 1 2 3 1 | 8 2.3|
Pigmentation, Multifocal | 3 | 2 2.5|
Cortex, Cyst | | 1 2.0|
Cortex, Hyperplasia, Atypical | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 3 | 2 3.0|
Transitional Epithelium, | | |
Mineralization | 1 | 4 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Calculus Gross Observation | | 1 |
Inflammation, Chronic Active, Focal | | 1 2.0|
Lumen, Calculus Micro Observation | | |
Only, Single | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|
| 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Mineralization, Multifocal | 4|
Parasite Metazoan | X X X |
Artery, Inflammation, Chronic Active,| |
Focal | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + M + M M + + + M + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + A + + M + + + + +|
Inflammation, Chronic Active, | |
Multifocal | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Angiectasis, Multifocal | 2 2 2|
Basophilic Focus | X X X|
Basophilic Focus, Multiple | X |
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Ballooning, Focal | 3 2 |
Eosinophilic Focus | |
Fatty Change, Diffuse | |
Fatty Change, Multifocal | 1 1 2 |
Granuloma, Multifocal | 3 |
Hemorrhage, Multifocal | 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal, Nodular | |
Necrosis, Focal | 1 |
Necrosis, Multifocal | 2 3 1 2 |
Bile Duct, Fibrosis, Multifocal | 3 |
Bile Duct, Hyperplasia, Multifocal | 1 3 3 3 4 2 2 2 2 3 2 2 1 2 1 1 3|
Centrilobular, Degeneration, Diffuse | |
Centrilobular, Degeneration, | |
Multifocal | 3 |
Centrilobular, Fatty Change, Diffuse | 3 3 |
Periportal, Cytomegaly, Diffuse | |
Periportal, Fatty Change, Diffuse | 4 |
__________________________________________________________________________|
Mesentery | + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|
| 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Accessory Spleen, Two | X |
Inflammation, Chronic Active, | |
Multifocal | |
Artery, Inflammation, Chronic, Focal | |
Artery, Mineralization, Multifocal | 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 2 |
Acinus, Atrophy, Multifocal | 1 2 3 2 1 3 2 1 2 2 |
Acinus, Hyperplasia, Focal | 3 |
Artery, Inflammation, Chronic Active,| |
Focal | 2 |
Artery, Inflammation, Chronic Active,| |
Multifocal | 4 |
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Chronic Active | 3 4 3 |
Mineralization, Diffuse | 4|
Ulcer | 3 |
Epithelium, Hyperplasia | 2 3 3 |
Submucosa, Edema, Diffuse | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
Mineralization, Diffuse | 4|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 3 2 2 3 2 2 2 2 2 2 1 3 3 3 1 2 3 4 3|
Mineralization, Multifocal | 4|
Atrium Left, Thrombosis | |
Myocardium, Fibrosis, Focal | 3 |
Valve, Fibrosis, Focal | 3 |
Valve, Inflammation, Focal, | |
Proliferative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|
| 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Diffuse, Fatty | 2 2 3 2 |
Degeneration, Fatty, Focal | 2 2 2 2 |
Degeneration, Fatty, Multifocal | 2 2 |
Hyperplasia, Focal | 1 1 1 1 |
Hyperplasia, Multifocal | 1 2 |
Hypertrophy, Focal | |
Hypertrophy, Multifocal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 |
Hyperplasia, Multifocal | 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hyperplasia, Multifocal | 3 |
Inflammation, Multifocal | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + + + + M + + + M + + + +|
Hyperplasia | 3 2 2 4|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | X 3 |
Pars Distalis, Degeneration, Fatty, | |
Focal | 2 |
Pars Distalis, Hyperplasia, Focal | 3 2 3 2 2 |
Pars Distalis, Hyperplasia | 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | 2|
Follicle, Cyst | 3 |
Follicular Cell, Degeneration, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Necrosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation, Multifocal | |
Granuloma Sperm, Single | 3 |
Left, Atrophy | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 3 |
Inflammation, Chronic Active | 2 3 3 |
Inflammation, Diffuse, Granulomatous | 3 |
Inflammation, Focal, Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|
| 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Granulomatous, | |
Multifocal | 2 3 2 1 3 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 |
Hyperplasia, Multifocal | 1 2 |
Inflammation, Chronic Active | 3 2 3 3 2 3 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + M M + + + M + + + + +|
Atrophy, Diffuse | 3 |
Fibrosis, Multifocal | |
Inflammation, Chronic Active, | |
Diffuse, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 |
Arteriole, Inflammation | 3 2 3 2 |
Capsule, Hyperplasia, Multifocal | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 2 4 2 3 |
Seminiferous Tubule, Degeneration | 3 2 2 3 |
Serosa, Necrosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Myeloid Cell, Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hemorrhage | |
Mediastinal, Hemorrhage | 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3|
Fibrosis, Multifocal | 2 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | |
Fibrosis, Focal | 3 2 |
Pigmentation, Hemosiderin | 2 3 2 |
Thrombosis, Single | 3 |
Capsule, Fibrosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|
| 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Capsule, Fibrosis, Multifocal | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M + M + + + M + + + + M +|
Depletion Lymphoid | 4|
Hyperplasia, Tubular | 2 3 |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Ectasia, Diffuse | 4 |
Ectasia, Multifocal | 4 2 4 3 4 |
Granuloma | 2 |
Hyperplasia, Diffuse | 2 2 3 2|
Hyperplasia, Focal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
Ulcer | |
Subcutaneous Tissue, Cyst | X |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3|
Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X |
Hemorrhage, Focal | |
Hemorrhage, Multifocal | |
Hydrocephalus | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + M + + + + + + + M + M M + + + M + + + + +|
Inflammation, Chronic, Multifocal | 2 |
Inflammation, Chronic Active, Focal | 2 2 1 |
Submucosa, Dilatation | 3|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal, Subacute | |
Mineralization, Multifocal | 4|
Artery, Mineralization, Focal | 2 |
Bronchus, Hyperplasia, Focal, | |
Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|
| 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Inflammation, Acute, | |
Multifocal | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 3|
Interstitium, Inflammation, Chronic | |
Active, Multifocal | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 3 |
Lumen, Foreign Body | 2 1 |
Mucosa, Inflammation, Chronic | 2 1 |
Mucosa, Inflammation, Chronic Active | 2 1 1 2 |
Mucosa, Thrombosis, Multifocal | 4 2 |
Nasolacrimal Duct, Exudate | |
Nasolacrimal Duct, Fungus | 4 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 1 4 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Olfactory Epithelium, Atrophy | 2 1|
Olfactory Epithelium, Cyst | 1 1 |
Olfactory Epithelium, Erosion | |
Olfactory Epithelium, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Metaplasia | 1 1 |
Respiratory Epithelium, Cyst | 1 2 2 1 |
Respiratory Epithelium, Hyperplasia, | |
Eosinophil | |
Respiratory Epithelium, Hyperplasia | 3 1 2 3 1 1 2 2 2 1 2 2 1 1 1 1 2 2 2|
Respiratory Epithelium, Hyperplasia, | |
Papillary | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Glands, Metaplasia, Focal, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | |
Mineralization, Diffuse | 4|
Nephropathy, Chronic | 4 4 4 4 4 3 4 4 4 4 4 1 4 4 2 4 4 4 3 4 4 4 4 4|
Pigmentation, Diffuse | |
Pigmentation, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 6| 7| 5| 7| 7| 7| 5| 7| 5| 5| 6| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 1| 0| 1| 9| 4| 2| 4| 0| 2| 0| 6| 2| 2| 1| 7| 2| 4| 4| 2| 2| 3| 3| 2|
| 9| 8| 1| 1| 9| 4| 4| 8| 8| 4| 9| 0| 7| 9| 9| 2| 8| 8| 7| 1| 8| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
300 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Inflammation, Chronic Active,| |
Focal | |
Cortex, Cyst | X |
Cortex, Hyperplasia, Atypical | 2 2 |
Proximal Convoluted Renal Tubule, | |
Necrosis, Acute, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
Ectasia | |
Inflammation, Diffuse, Subacute | |
Subserosa, Mineralization, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7| |
DAY ON TEST | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3| |
| 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Parasite Metazoan | X X X X| 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Mineralization, Multifocal | | 1 4.0|
Parasite Metazoan | X X X| 6 |
Artery, Inflammation, Chronic Active,| | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + M + + + + + M + M M + + + + +| 40 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + M + + + + + + + + + + + + + + + + + + M| 44 |
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A M + + + + + + + + + + + + M + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 | 2 2.5|
Angiectasis, Multifocal | | 3 2.0|
Basophilic Focus | | 3 |
Basophilic Focus, Multiple | | 1 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Degeneration, Ballooning, Focal | 2 | 3 2.3|
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 4 | 1 4.0|
Fatty Change, Multifocal | 1 1 2 1 1 | 8 1.3|
Granuloma, Multifocal | 2 2 3 | 4 2.5|
Hemorrhage, Multifocal | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 3 |
Hyperplasia, Focal, Nodular | 3 | 1 3.0|
Necrosis, Focal | | 1 1.0|
Necrosis, Multifocal | 2 3 2 3 | 8 2.3|
Bile Duct, Fibrosis, Multifocal | | 1 3.0|
Bile Duct, Hyperplasia, Multifocal | 2 3 2 2 2 3 1 3 2 4 1 3 3| 30 2.3|
Centrilobular, Degeneration, Diffuse | 2 | 1 2.0|
Centrilobular, Degeneration, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7| |
DAY ON TEST | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3| |
| 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Multifocal | 2 2 3 | 4 2.5|
Centrilobular, Fatty Change, Diffuse | 4 3 | 4 3.3|
Periportal, Cytomegaly, Diffuse | 1 | 1 1.0|
Periportal, Fatty Change, Diffuse | 4 | 2 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Accessory Spleen, Two | | 1 |
Inflammation, Chronic Active, | | |
Multifocal | 2 | 1 2.0|
Artery, Inflammation, Chronic, Focal | 2 | 1 2.0|
Artery, Mineralization, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | | 2 1.5|
Acinus, Atrophy, Multifocal | 2 1 2 2 4 2 3 1 2 2 | 20 2.0|
Acinus, Hyperplasia, Focal | | 1 3.0|
Artery, Inflammation, Chronic Active,| | |
Focal | 3 | 2 2.5|
Artery, Inflammation, Chronic Active,| | |
Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 3 | 5 3.2|
Mineralization, Diffuse | | 1 4.0|
Ulcer | 4 4 | 3 3.7|
Epithelium, Hyperplasia | 3 2 2 | 6 2.5|
Submucosa, Edema, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active, Focal | 3 | 1 3.0|
Mineralization, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 4 2 2 1 2 2 3 2 1 3 3 2 2 2 2 3 1 2 3 | 40 2.3|
Mineralization, Multifocal | | 1 4.0|
Atrium Left, Thrombosis | 3 4 | 2 3.5|
Myocardium, Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7| |
DAY ON TEST | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3| |
| 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Valve, Fibrosis, Focal | | 1 3.0|
Valve, Inflammation, Focal, | | |
Proliferative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X X X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Degeneration, Diffuse, Fatty | 2 2 2 2 1 | 9 2.0|
Degeneration, Fatty, Focal | 2 2 | 6 2.0|
Degeneration, Fatty, Multifocal | 2 | 3 2.0|
Hyperplasia, Focal | 1 2 1 2 2 2 | 10 1.4|
Hyperplasia, Multifocal | | 2 1.5|
Hypertrophy, Focal | 1 | 1 1.0|
Hypertrophy, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + M + + + + + + + + + + + + + + + + + + + + M| 46 |
Hyperplasia, Focal | 1 2 1 | 5 1.8|
Hyperplasia, Multifocal | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 3 | 2 2.0|
Hyperplasia, Multifocal | 2 2 4 4 | 5 3.0|
Inflammation, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 45 |
Hyperplasia | 1 | 5 2.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 | 3 2.7|
Pars Distalis, Cyst | 4 2 3 | 5 3.0|
Pars Distalis, Degeneration, Fatty, | | |
Focal | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 3 3 | 7 2.6|
Pars Distalis, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 1 | 2 1.5|
C-Cell, Hyperplasia, Multifocal | 3 1 | 3 2.0|
Follicle, Cyst | 3 | 2 3.0|
Follicular Cell, Degeneration, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7| |
DAY ON TEST | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3| |
| 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Necrosis, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation, Multifocal | 3 | 1 3.0|
Granuloma Sperm, Single | | 1 3.0|
Left, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | A + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Ectasia | 3 | 3 3.3|
Inflammation, Chronic Active | 2 | 4 2.5|
Inflammation, Diffuse, Granulomatous | | 1 3.0|
Inflammation, Focal, Granulomatous | 2 2| 3 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 2 3 2 1 2 3 2 2 2 1 1 3 2 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Prostate | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 2 3 | 5 2.4|
Hyperplasia, Multifocal | 2 2 3 1 | 6 1.8|
Inflammation, Chronic Active | 4 3 1 1 2 | 13 2.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + M + + M + + + + +| 43 |
Atrophy, Diffuse | 2 3 3 2 | 5 2.6|
Fibrosis, Multifocal | 2 | 1 2.0|
Inflammation, Chronic Active, | | |
Diffuse, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | | 1 2.0|
Arteriole, Inflammation | | 4 2.5|
Capsule, Hyperplasia, Multifocal | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 2 | 2 2.0|
Seminiferous Tubule, Atrophy | 2 3 3 3 2 4 3 3 3 | 13 2.8|
Seminiferous Tubule, Degeneration | | 4 2.5|
Serosa, Necrosis, Focal | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 2| 5 2.6|
Myeloid Cell, Hyperplasia | 4 3 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7| |
DAY ON TEST | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3| |
| 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Hemorrhage | 3 | 1 3.0|
Mediastinal, Hemorrhage | 3 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 4 2 | 3 2.7|
Hyperplasia, Plasma Cell | 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Depletion Lymphoid | | 1 3.0|
Fibrosis, Multifocal | | 1 2.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
Hyperplasia, Re Cell | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3| 1 3.0|
Depletion Lymphoid | 3| 1 3.0|
Fibrosis, Focal | 2 3 | 4 2.5|
Pigmentation, Hemosiderin | 3 3 2 2 | 7 2.4|
Thrombosis, Single | | 1 3.0|
Capsule, Fibrosis, Focal | | 1 4.0|
Capsule, Fibrosis, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | A M + + M + + + + + + + + + M + M + + M + + + M +| 38 |
Depletion Lymphoid | | 1 4.0|
Hyperplasia, Tubular | 2 3 3 2 | 6 2.5|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + + + + + + + + + + + + + + + M + + +| 46 |
Ectasia, Diffuse | 3 4 4 | 4 3.8|
Ectasia, Multifocal | 3 | 6 3.3|
Granuloma | | 1 2.0|
Hyperplasia, Diffuse | 2 2 1 | 7 2.0|
Hyperplasia, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 3.0|
Ulcer | 4 | 1 4.0|
Subcutaneous Tissue, Cyst | | 1 |
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7| |
DAY ON TEST | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3| |
| 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 2 2.5|
Osteopetrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X 3 X | 9 3.0|
Hemorrhage, Focal | 3 | 1 3.0|
Hemorrhage, Multifocal | 4 2 | 2 3.0|
Hydrocephalus | 2 2 2 2 | 8 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + M + + + + + M + M + + + + +| 41 |
Inflammation, Chronic, Multifocal | 1 | 2 1.5|
Inflammation, Chronic Active, Focal | 2 2| 5 1.8|
Submucosa, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Multifocal, Subacute | 2 | 1 2.0|
Mineralization, Multifocal | | 1 4.0|
Artery, Mineralization, Focal | | 1 2.0|
Bronchus, Hyperplasia, Focal, | | |
Lymphoid | 2 | 1 2.0|
Interstitium, Inflammation, Acute, | | |
Multifocal | 2| 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 1 | 2 2.0|
Interstitium, Inflammation, Chronic | | |
Active, Multifocal | | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 2 | 2 2.5|
Lumen, Foreign Body | 1 1 | 4 1.3|
Mucosa, Inflammation, Chronic | 2 1 2 1| 6 1.5|
Mucosa, Inflammation, Chronic Active | | 4 1.5|
Mucosa, Thrombosis, Multifocal | 3 | 3 3.0|
Nasolacrimal Duct, Exudate | 3 1 2 | 3 2.0|
Nasolacrimal Duct, Fungus | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 5| 5| 6| 7| 6| 6| 7| |
DAY ON TEST | 7| 4| 1| 5| 3| 6| 4| 6| 2| 3| 8| 3| 2| 3| 3| 6| 4| 3| 7| 0| 1| 3| 3| 6| 3| |
| 9| 8| 7| 3| 0| 6| 8| 0| 9| 0| 9| 0| 4| 0| 0| 9| 1| 0| 5| 6| 1| 1| 8| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
300 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 1 3 1 | 10 1.7|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 3 1 2 3 | 5 2.2|
Olfactory Epithelium, Atrophy | 2 | 3 1.7|
Olfactory Epithelium, Cyst | 1 1 1 1 | 6 1.0|
Olfactory Epithelium, Erosion | 2 | 1 2.0|
Olfactory Epithelium, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Olfactory Epithelium, Metaplasia | 2 2 | 4 1.5|
Respiratory Epithelium, Cyst | 1 2 1 1 1| 9 1.3|
Respiratory Epithelium, Hyperplasia, | | |
Eosinophil | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | 2 2 1 1 2 2 1 1 | 27 1.6|
Respiratory Epithelium, Hyperplasia, | | |
Papillary | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 2 1.5|
Glands, Metaplasia, Focal, Squamous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal, Suppurative | 1 | 1 1.0|
Mineralization, Diffuse | | 1 4.0|
Nephropathy, Chronic | 2 1 3 1 4 4 3 4 4 4 2 4 4 4 4 4 2 4 1 3 4 3 4 4| 48 3.5|
Pigmentation, Diffuse | 1 2 3 1 3 | 5 2.0|
Pigmentation, Multifocal | | 1 2.0|
Artery, Inflammation, Chronic Active,| | |
Focal | 3 | 1 3.0|
Cortex, Cyst | X 3| 3 3.0|
Cortex, Hyperplasia, Atypical | | 2 2.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis, Acute, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 4 | 1 4.0|
Inflammation, Diffuse, Subacute | 3 | 1 3.0|
Subserosa, Mineralization, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|
| 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | M + M + + A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + A + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + +|
Inflammation, Acute, Multifocal | 2|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X |
Congestion | 4 3 |
Cytomegaly, Focal | |
Cytomegaly, Multifocal | |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 4 3 2|
Fatty Change, Focal | 3 |
Fatty Change, Multifocal | 1 2 |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | |
Mitotic Alteration | 1 |
Necrosis, Focal | |
Necrosis, Multifocal | 2 |
Pigmentation, Multifocal | 2 |
Vacuolization Cytoplasmic, Multifocal| |
Bile Duct, Hyperplasia, Multifocal | 2 3 2 2 2 3 1 3 1 2 |
Centrilobular, Degeneration, Diffuse | 3 2 |
Centrilobular, Fatty Change, Diffuse | 3 |
Centrilobular, Necrosis, Multifocal | |
Periportal, Fatty Change, Diffuse | 2 |
Portal, Fibrosis, Multifocal | 2 |
Portal, Inflammation, Chronic Active,| |
Multifocal | 1 |
__________________________________________________________________________|
Mesentery | + |
Artery, Ectasia, Multifocal | |
Artery, Inflammation, Chronic, | |
Multifocal | |
Artery, Mineralization, Multifocal | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + M + + + + + + + |
Acinus, Atrophy, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|
| 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Atrophy, Multifocal | 2 |
Artery, Ectasia, Multifocal | |
Artery, Fibrosis | |
Artery, Inflammation, Chronic, | |
Multifocal | |
Artery, Mineralization, Multifocal | |
__________________________________________________________________________|
Pharynx | |
Inflammation, Chronic Active, | |
Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + |
Inflammation, Chronic Active | 3 4 |
Ulcer | 4 |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Cardiomyopathy | 1 3 4 2 2 3 2 |
Atrium Left, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + +|
Degeneration, Diffuse, Fatty | 3 2 2 |
Degeneration, Fatty, Focal | 2 2 3 |
Degeneration, Fatty, Multifocal | |
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M|
Hyperplasia, Focal | 2 3 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + |
Hyperplasia, Multifocal | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|
| 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 2 3 |
Pars Distalis, Hyperplasia, Focal | 3 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + |
C-Cell, Hyperplasia, Focal | 2 |
C-Cell, Hyperplasia, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + M |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + +|
Abscess | 4 |
Ectasia | 3 4|
Inflammation, Granulomatous, | |
Multifocal | 2 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + |
Hyperplasia, Multifocal | 3 4 |
Inflammation, Chronic Active | 1 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + M + M M + + M + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + M + +|
Hemorrhage | |
Mineralization, Multifocal | |
Arteriole, Inflammation | 3 |
Interstitial Cell, Hyperplasia | 3 2|
Seminiferous Tubule, Atrophy | 3 4 3 2 3|
Serosa, Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Atrophy | 3 |
Hyperplasia | 2 |
Metaplasia, Osseous | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Hemorrhage | 2 |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + |
Hemorrhage | 3 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + |
Hemorrhage | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|
| 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis, Focal | 2 |
Fibrosis, Multifocal | 3 |
Hematopoietic Cell Proliferation | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + M + M + + + + |
Angiectasis, Multifocal | |
Hemorrhage | 3 |
Hyperplasia, Tubular | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + |
Ectasia, Diffuse | 4 2 3 |
Ectasia, Multifocal | 4 3 1 2 3 2 |
Hyperplasia, Diffuse | 2 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X 4 |
Hyperkeratosis | 4 3 |
Hyperplasia, Squamous | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Compression | X X X X X |
Hydrocephalus | 2 3 |
Perivascular, Infiltration Cellular, | |
Multifocal, Mixed Cell | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M M M M + M + + + M |
Inflammation, Chronic Active, Focal | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 3 |
Interstitium, Inflammation, Chronic, | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|
| 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Diffuse | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 2 3 1 |
Interstitium, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 |
Lumen, Foreign Body | 3 1 |
Mucosa, Inflammation, Chronic | 2 3 1 |
Mucosa, Inflammation, Chronic Active | 3 1 2 |
Mucosa, Thrombosis, Multifocal | 2 3 |
Nasolacrimal Duct, Exudate | 4 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 1 2 2 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Cyst | 1 |
Olfactory Epithelium, Erosion | 3 1 1 2 1|
Olfactory Epithelium, Metaplasia | 2 1 1 |
Respiratory Epithelium, Cyst | 2 1 2 2 2 1 |
Respiratory Epithelium, Hyperplasia | 1 1 3 1 2 2 2 2 2 1 1 2|
Respiratory Epithelium, Hyperplasia, | |
Papillary | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + M + + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Anterior, Synechia | 4 |
Cornea, Inflammation, Chronic Active | |
Lens, Right, Cataract | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Acute, Multifocal, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 6| 7| 6| 5| 4| 6| 5| 7| 6| 7| 6| 6| 5| 7| 7| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 2| 2| 3| 3| 9| 2| 9| 5| 8| 6| 3| 2| 8| 2| 2| 9| 3| 2| 2| 8| 5| 2| 8| 1| 8|
| 9| 9| 3| 3| 5| 8| 7| 4| 4| 0| 9| 9| 9| 8| 4| 7| 9| 8| 8| 0| 4| 8| 3| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
100 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic | 2 4 4 4 3 2 2 4 2 2 4 3 4 4 4 4 4|
Pigmentation, Diffuse | 3 |
Pigmentation, Multifocal | |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3| |
| 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + A M + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + | 14 |
Inflammation, Acute, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M A + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + | 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + +| 42 |
Angiectasis, Focal | 3 | 3 2.3|
Basophilic Focus | X | 4 |
Basophilic Focus, Multiple | X X | 3 |
Congestion | | 2 3.5|
Cytomegaly, Focal | 2 | 1 2.0|
Cytomegaly, Multifocal | 2 | 1 2.0|
Eosinophilic Focus | | 1 |
Fatty Change, Diffuse | | 3 3.0|
Fatty Change, Focal | | 1 3.0|
Fatty Change, Multifocal | 3 | 3 2.0|
Hepatodiaphragmatic Nodule | X X| 3 |
Hepatodiaphragmatic Nodule, Multiple | X | 1 |
Mitotic Alteration | 2 | 2 1.5|
Necrosis, Focal | 2 | 1 2.0|
Necrosis, Multifocal | 1 2 | 3 1.7|
Pigmentation, Multifocal | | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| 2 | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | 3 1 2 1 2 2 2 2 1 2 3 3 2| 23 2.0|
Centrilobular, Degeneration, Diffuse | 2 2 2 | 5 2.2|
Centrilobular, Fatty Change, Diffuse | 4 | 2 3.5|
Centrilobular, Necrosis, Multifocal | 3 | 1 3.0|
Periportal, Fatty Change, Diffuse | | 1 2.0|
Portal, Fibrosis, Multifocal | | 1 2.0|
Portal, Inflammation, Chronic Active,| | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Artery, Ectasia, Multifocal | 4 | 1 4.0|
Artery, Inflammation, Chronic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3| |
| 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Multifocal | 4 | 1 4.0|
Artery, Mineralization, Multifocal | 4 | 1 4.0|
Fat, Necrosis, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + | 19 |
Acinus, Atrophy, Diffuse | 4 | 1 4.0|
Acinus, Atrophy, Multifocal | 3 | 2 2.5|
Artery, Ectasia, Multifocal | 4 | 1 4.0|
Artery, Fibrosis | 3 | 1 3.0|
Artery, Inflammation, Chronic, | | |
Multifocal | 4 | 1 4.0|
Artery, Mineralization, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Inflammation, Chronic Active, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + M | 13 |
Inflammation, Chronic Active | | 2 3.5|
Ulcer | | 1 4.0|
Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + | 14 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Dysplasia | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + M + + | 14 |
Cardiomyopathy | 1 1 2 | 10 2.1|
Atrium Left, Thrombosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + | 24 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + | 20 |
Degeneration, Diffuse, Fatty | 1 3 | 5 2.2|
Degeneration, Fatty, Focal | 1 | 4 2.0|
Degeneration, Fatty, Multifocal | 2 | 1 2.0|
Hyperplasia, Focal | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3| |
| 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + A + + + + + | 21 |
Hyperplasia, Focal | 2 | 3 2.3|
Hyperplasia, Multifocal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + | 16 |
Hyperplasia, Multifocal | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 14 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + + + + | 35 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 2 1 | 4 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 3 2.3|
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 20 |
C-Cell, Hyperplasia, Focal | | 1 2.0|
C-Cell, Hyperplasia, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 18 |
Abscess | 4 | 2 4.0|
Ectasia | | 2 3.5|
Inflammation, Granulomatous, | | |
Multifocal | 2 | 4 1.8|
__________________________________________________________________________|____________|
Prostate | + M + + + + + + | 18 |
Hyperplasia, Multifocal | | 2 3.5|
Inflammation, Chronic Active | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + M + M + + M + | 13 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + +| 42 |
Hemorrhage | 4 | 1 4.0|
Mineralization, Multifocal | 2 | 1 2.0|
Arteriole, Inflammation | 2 | 2 2.5|
Interstitial Cell, Hyperplasia | 2 2 | 4 2.3|
Seminiferous Tubule, Atrophy | 3 3 2 2 2 3 | 11 2.7|
Serosa, Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3| |
| 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + | 15 |
Atrophy | | 1 3.0|
Hyperplasia | 2 | 2 2.0|
Metaplasia, Osseous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 27 |
Mediastinal, Hemorrhage | 4 | 2 3.0|
Pancreatic, Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + A M + + | 14 |
Hemorrhage | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + A + + + | 17 |
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 35 |
Congestion | | 1 4.0|
Fibrosis, Focal | 3 | 2 2.5|
Fibrosis, Multifocal | 4 | 2 3.5|
Hematopoietic Cell Proliferation | 4 3 | 2 3.5|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + M + + | 14 |
Angiectasis, Multifocal | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Tubular | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + | 20 |
Ectasia, Diffuse | 3 | 4 3.0|
Ectasia, Multifocal | 2 | 7 2.4|
Hyperplasia, Diffuse | 2 | 2 2.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 23 |
Cyst Epithelial Inclusion | X | 3 4.0|
Hyperkeratosis | | 2 3.5|
Hyperplasia, Squamous | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3| |
| 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Osteodystrophy | 3 4 | 3 3.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 4 |
Hemorrhage, Acute | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 15 |
Compression | | 5 |
Hydrocephalus | | 2 2.5|
Perivascular, Infiltration Cellular, | | |
Multifocal, Mixed Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + M M M | 5 |
Inflammation, Chronic Active, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 2 3.0|
Interstitium, Inflammation, Chronic, | | |
Diffuse | 2 | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 1 | 4 1.8|
Interstitium, Mineralization, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 2 4 3 2 | 5 2.4|
Lumen, Foreign Body | 1 1 1 | 5 1.4|
Mucosa, Inflammation, Chronic | 1 | 4 1.8|
Mucosa, Inflammation, Chronic Active | 2 4 1 2 1 2 | 9 2.0|
Mucosa, Thrombosis, Multifocal | 1 4 4 | 5 2.8|
Nasolacrimal Duct, Exudate | 3 1 | 3 2.7|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 1 1 2 1 1 1 1 1| 16 1.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05070-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC VINYL TOLUENE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:28:19
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 3| 5| 6| 7| 6| 4| 7| 6| 4| 6| 6| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 5| 7| 3| 9| 9| 1| 2| 8| 6| 3| 9| 9| 6| 1| 0| 1| 3| 3| 2| 3| 2| 3| 3| |
| 0| 7| 8| 9| 0| 3| 3| 1| 9| 7| 5| 0| 4| 9| 6| 3| 0| 9| 0| 0| 7| 0| 3| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
100 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Cyst | 1 1 1 | 4 1.0|
Olfactory Epithelium, Erosion | 1 1 1 | 8 1.4|
Olfactory Epithelium, Metaplasia | 2 1 1| 6 1.3|
Respiratory Epithelium, Cyst | 1 1 1 2 2 1 2 | 13 1.5|
Respiratory Epithelium, Hyperplasia | 2 1 1 2 2 1 3 1 1 1 1 1 | 24 1.5|
Respiratory Epithelium, Hyperplasia, | | |
Papillary | 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + | 14 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Anterior, Synechia | | 1 4.0|
Cornea, Inflammation, Chronic Active | 4 | 1 4.0|
Lens, Right, Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + + + + + + + | 35 |
Bacterium | 4 | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Acute, Multifocal, | | |
Suppurative | 4 | 1 4.0|
Nephropathy, Chronic | 4 2 4 1 3 4 4 4 2 2 4 1 4 4 4 | 32 3.2|
Pigmentation, Diffuse | 1 | 2 2.0|
Pigmentation, Multifocal | 2 | 1 2.0|
Cortex, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + M | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
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