TDMS Study 05070-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Midwest Research Inst DATE: 09/08/94
EXP: 05070 VINYL TOLUENE TIME: 22:47:29
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 56406
CONT: N01-ES-38042 CAS: 25013154
PATHOLOGIST: M. STEDHAM
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Midwest Research Inst DATE: 09/08/94
EXP: 05070 VINYL TOLUENE TIME: 22:47:29
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 56406
CONT: N01-ES-38042 CAS: 25013154
PATHOLOGIST: M. STEDHAM
VINYL TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 371 422 492 506 511 511 520 525 532 553 |
| 557 599 607 613 621 623 623 633 638 643 |
| 647 652 658 673 683 693 697 700 714 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 393 465 479 484 499 519 533 539 539 554 |
| 554 583 593 611 613 623 624 627 633 637 |
| 658 660 666 680 687 687 689 694 695 697 |
| 697 700 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 31 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 506 512 519 529 541 541 548 548 567 575 |
| 589 611 617 638 644 647 648 653 660 666 |
| 667 669 678 679 694 700 701 704 711 721 |
| 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VINYL TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 95.9 95.9 81.6 75.5 53.1 38.8 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 82.0 74.0 56.0 34.0 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 88.0 78.0 62.0 38.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 100 PPM 300 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 38.8% 34.0% 38.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.762N P=0.825 P=0.878N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 597.9 606.8 626.0 |
|NATURAL DEATHS (C) | (16.0) (14.6) (12.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 648.4 648.0 664.8 |
|(STANDARD ERROR) | (13.4) (12.6) (10.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
VINYL TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 166 434 470 545 553 582 592 613 630 630 |
| 635 659 679 683 688 701 708 708 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 421 495 499 526 548 560 583 624 624 637 |
| 637 659 661 675 693 696 701 703 707 707 |
| 709 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 300 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 414 434 444 456 499 506 526 576 576 582 |
| 606 614 626 637 646 680 681 683 690 697 |
| 709 709 714 718 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
VINYL TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 98.0 94.0 92.0 86.0 76.0 62.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 98.0 98.0 92.0 86.0 74.0 56.0 |
| | |
| | |
|300 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 86.0 80.0 70.0 52.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 100 PPM 300 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 56.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.359 P=0.713 P=0.383 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 599.7 626.3 601.0 |
|NATURAL DEATHS (C) | (30.3) (18.1) (20.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 679.2 683.3 667.0 |
|(STANDARD ERROR) | (14.4) (10.7) (13.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
VINYL TOLUENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
100 PPM = 2
300 PPM = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 2 1 2 33
| 1 2 221 13 33
| 2 2 3 3
90 + 2 2
| 1 1 233
P | 3 3
E | 112 123 3
R 80 + 11 3 3
C | 1 2 31 3
E | 2 21123 3
N | 111
T 70 + 22 33
| 22
S | 121 33 3
U | 11 33
R 60 + 2112
V | 11 2
I | 2232
V | 1 1223
A 50 + 111
L | 113
| 2233
| 1 13
40 + 111
| 3
| 2 2 2
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 25 obs hidden.
VINYL TOLUENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
100 PPM = 2
300 PPM = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 32
|
| 1 321 2
| 1 3 1 22
95 +
| 3 3 1 2 2 1
| 3 3 2 11
|
90 + 33 12 1
|
| 3 3 2 1 1
| 3 32 1 1 2
P 85 +
E | 1 1
R | 33 22
C |
E 80 + 3 3 11
N |
T | 33 1 1
| 3 3 1 1
S 75 +
U | 33 2 11
R | 3 3 211
V |
I 70 + 3 3121
V |
A | 211
L |
65 +
| 33 11
| 33 11
|
60 + 322
|
|
| 2 2
55 +
| 33
| 33
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
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