TDMS Study 05075-02 Pathology Tables
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57-41-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|
| 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + M + M + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + M A + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
Mesenteric, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Tooth | + + + |
Peridontal Tissue, Lymphoma | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|
| 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Malignant Histiocytic | X |
Peridontal Tissue, Lymphoma | |
Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + A + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + A + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Benign | |
Luteoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Periovarian Tissue, Hemangiosarcoma | X |
Periovarian Tissue, Lymphoma | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|
| 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Malignant Lymphocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Polyp Stromal | |
Sarcoma Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Femoral, Hemangiosarcoma | X |
Femoral, Lymphoma Malignant | |
Histiocytic | X |
Femoral, Lymphoma Malignant | |
Lymphocytic | X X |
Vertebral, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant | |
Histiocytic | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | X X |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Pancreatic, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|
| 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic | |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + + M + M + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M A + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Skin | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Myxoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 7| 3| 3| 3| 4| 4| 3|
| 6| 6| 6| 6| 0| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 0| 9| 0| 0| 9| 9| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spinal Cord | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
Adenocarcinoma | |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1| |
| 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + A + + + +| 45 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leiomyoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + A + + + M| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hepatocellular Adenoma | X | 5 |
Lymphoma Malignant Histiocytic | X X X | 4 |
Lymphoma Malignant Lymphocytic | X X X | 5 |
Lymphoma Malignant Mixed | X | 3 |
Mesenteric, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Lymphoma Malignant Histiocytic | X X X | 4 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1| |
| 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 5 |
Peridontal Tissue, Lymphoma | | |
Malignant Histiocytic | | 1 |
Peridontal Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Complex | X | 1 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + M| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | M I + + + M M + + + + + + + + + + + + + + + + + +| 44 |
Pars Distalis, Adenoma | X X | 6 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | X | 2 |
Follicular Cell, Adenoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1| |
| 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cystadenoma | | 1 |
Granulosa Cell Tumor Benign | X | 1 |
Luteoma | | 1 |
Lymphoma Malignant Histiocytic | X X X | 4 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Periovarian Tissue, Hemangiosarcoma | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X X X X X | 5 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X X X X | 5 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Polyp Stromal | X | 1 |
Sarcoma Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Femoral, Hemangiosarcoma | | 1 |
Femoral, Lymphoma Malignant | | |
Histiocytic | | 1 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | X | 3 |
Vertebral, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1| |
| 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic | X X | 2 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X X X | 4 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X X X | 4 |
Mandibular, Lymphoma Malignant Mixed | X X | 4 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X X | 2 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Renal, Lymphoma Malignant Histiocytic| X X | 2 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 12 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hemangiosarcoma | X | 3 |
Lymphoma Malignant Histiocytic | X X X | 4 |
Lymphoma Malignant Lymphocytic | X X X X X | 7 |
Lymphoma Malignant Mixed | X X X X | 8 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + M M + M M| 42 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X X X | 5 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1| |
| 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Adenocarcinoma | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Myxoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 5 |
Lymphoma Malignant Histiocytic | X X X | 4 |
Lymphoma Malignant Lymphocytic | X X X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X X | 2 |
__________________________________________________________________________|____________|
Trachea | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 2| 4| 3| 5| 4| 4| 1| |
| 0| 8| 0| 3| 3| 3| 3| 4| 4| 4| 9| 4| 4| 5| 1| 5| 5| 5| 6| 5| 1| 5| 6| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + | 8 |
Adenocarcinoma | X | 1 |
Adenoma | X X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Lymphoma Malignant Histiocytic | X X X | 4 |
Lymphoma Malignant Lymphocytic | X X X | 4 |
Lymphoma Malignant Mixed | X X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X X X | 5 |
Lymphoma Malignant Lymphocytic | X X X X X X X | 9 |
Lymphoma Malignant Mixed | X X X X | 9 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + A + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Lymphoma Malignant Histiocytic | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + A + + + M + + + + |
Pars Distalis, Adenoma | X X X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + +|
Choriocarcinoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Femoral, Hemangiosarcoma | |
Femoral, Lymphoma Malignant | |
Histiocytic | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + |
Lumbar, Lymphoma Malignant Mixed | |
Mandibular, Lymphoma Malignant | |
Histiocytic | X X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + I M + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + |
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 0| 3| 4| 3| 3| 7| 3| 3| 7| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 8| 1| 6| 3| 6| 8| 6| 7| 9| 7| 7| 4| 7| 7| 8| 8| 8| 0| 8| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Adenocarcinoma | X |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6| |
| 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + A| 14 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A| 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A| 15 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A| 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A| 16 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X X | 2 |
Hemangiosarcoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X X X X X | 8 |
Hepatocellular Adenoma, Multiple | X X | 3 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A| 15 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + M + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + +| 20 |
Lymphoma Malignant Lymphocytic | X | 1 |
Squamous Cell Papilloma | X | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + +| 16 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + +| 16 |
Lymphoma Malignant Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6| |
| 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + +| 16 |
Lymphoma Malignant Histiocytic | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + +| 16 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + +| 19 |
Pars Distalis, Adenoma | X X | 8 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + +| 28 |
Choriocarcinoma | X| 1 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 36 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + +| 16 |
Femoral, Hemangiosarcoma | X X | 2 |
Femoral, Lymphoma Malignant | | |
Histiocytic | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + + + + +| 18 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 3 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6| |
| 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic | X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 7 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + +| 23 |
Hemangiosarcoma | X X X | 4 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X X | 5 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + M| 12 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + +| 15 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + +| 16 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X X | 3 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + +| 16 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + +| 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 3| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 0| 6| 0| 4| 4| 8| 4| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 8| 6| |
| 0| 0| 0| 3| 3| 3| 7| 0| 7| 3| 4| 0| 4| 4| 4| 5| 5| 2| 5| 5| 3| 6| 6| 6| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + +| 16 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | M + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
Adenocarcinoma | X X | 3 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + +| 16 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + +| 15 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X X X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|
| 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Pancreas | + + + + + + |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|
| 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + |
Femoral, Lymphoma Malignant | |
Histiocytic | X |
Femoral, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Lumbar, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mandibular, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant Mixed | |
Mandibular, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant Mixed| |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Mandibular, Sarcoma, | |
Metastatic, Eye | |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|
| 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Thymus | + + + + + + |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Myxosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Femur, Osteoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
Sarcoma, Metastatic, Eye | |
__________________________________________________________________________|
Nose | + + + + + + |
Sarcoma, Metastatic, Eye | |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Sarcoma | |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 4| 2| 4|
| 6| 6| 8| 0| 9| 6| 6| 4| 7| 7| 7| 7| 7| 8| 8| 5| 8| 8| 9| 9| 9| 9| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
60 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4| |
| 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
60 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + | 14 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 2 |
Hepatocellular Carcinoma | X X | 4 |
Hepatocellular Adenoma | X X X X X X | 10 |
Hepatocellular Adenoma, Multiple | X | 1 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Mixed | X X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 15 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + | 14 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + +| 20 |
Squamous Cell Papilloma | X | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + M + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4| |
| 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
60 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + M + | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + M + | 14 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + | 14 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + A + | 14 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + | 17 |
Pars Distalis, Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + M M + +| 36 |
Cystadenoma | | 1 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + +| 31 |
Lymphoma Malignant Histiocytic | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 15 |
Femoral, Lymphoma Malignant | | |
Histiocytic | X | 2 |
Femoral, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + | 16 |
Lumbar, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mandibular, Lymphoma Malignant Mixed | X | 1 |
Mandibular, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4| |
| 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
60 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Mandibular, Sarcoma, | | |
Metastatic, Eye | X | 1 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 5 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 27 |
Lymphoma Malignant Histiocytic | X X | 4 |
Lymphoma Malignant Mixed | X X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Thymus | M + M + + M + M + | 11 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + | 12 |
Adenocarcinoma | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 17 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Myxosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 16 |
Femur, Osteoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 15 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 20 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 2 |
Lymphoma Malignant Histiocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 4| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 8| 4| 8| 6| 4| 4| 4| 4| 4| |
| 3| 6| 2| 0| 5| 8| 0| 3| 3| 3| 3| 4| 4| 4| 4| 1| 7| 5| 1| 5| 5| 5| 5| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
60 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 2 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Sarcoma, Metastatic, Eye | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 15 |
Sarcoma, Metastatic, Eye | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 16 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X X | 6 |
Lymphoma Malignant Mixed | X X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|
| 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Gallbladder | + A + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
Leiomyosarcoma | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
Squamous Cell Papilloma | |
Squamous Cell Papilloma, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Lymphoma Malignant Histiocytic | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|
| 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + |
Cystadenoma | |
Hemangioma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Axillary, Lymphoma Malignant | |
Histiocytic | |
Axillary, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant Mixed | X |
Mandibular, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | + + + M + + |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 5| 5| 3| 3| 3| 3| 3| 4| 9| 4| 4|
| 6| 6| 6| 6| 7| 5| 1| 7| 7| 7| 8| 8| 8| 1| 6| 9| 8| 9| 9| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + |
Adenocarcinoma | X X |
__________________________________________________________________________|
Skin | + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Nose | + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
Adenocarcinoma | X |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| |
DAY ON TEST | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7| |
| 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + +| 12 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + +| 13 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + +| 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + +| 14 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + +| 15 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X | 4 |
Hepatocellular Adenoma | X X X X| 7 |
Hepatocellular Adenoma, Multiple | X X X | 5 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | A + + + + + +| 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Stomach | A + + + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + + + + +| 20 |
Squamous Cell Papilloma | X X | 2 |
Squamous Cell Papilloma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + +| 13 |
Lymphoma Malignant Histiocytic | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + +| 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| |
DAY ON TEST | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7| |
| 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + +| 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + +| 17 |
Pars Distalis, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + +| 14 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + +| 28 |
Cystadenoma | X X X | 3 |
Hemangioma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + +| 33 |
Lymphoma Malignant Histiocytic | X X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 20 |
Axillary, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Axillary, Lymphoma Malignant Mixed | X | 1 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 2 |
Mandibular, Lymphoma Malignant Mixed | X | 2 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| |
DAY ON TEST | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7| |
| 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 6 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X X X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 23 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Mixed | X X X X | 7 |
__________________________________________________________________________|____________|
Thymus | M + + + M + M| 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + +| 13 |
Adenocarcinoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + +| 13 |
Lymphoma Malignant Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + +| 15 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenocarcinoma | | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + +| 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| |
DAY ON TEST | 3| 4| 3| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 7| |
| 5| 3| 5| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 5| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + +| 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X X | 4 |
Lymphoma Malignant Mixed | X X X X X X | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|
| 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + A + + + + + + |
__________________________________________________________________________|
Intestine Large | + A + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + |
Leiomyosarcoma | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + M + + + + |
__________________________________________________________________________|
Intestine Small | + A + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + M + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + |
Adenocarcinoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X X X X X X X X|
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + A + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | + A + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|
| 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + |
Cystadenoma | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Femoral, Lymphoma Malignant | |
Histiocytic | X |
Femoral, Lymphoma Malignant Mixed | X |
Vertebral, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Inguinal, Lymphoma Malignant | |
Histiocytic | X |
Mandibular, Lymphoma Malignant | |
Histiocytic | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X |
__________________________________________________________________________|
Thymus | + A + + + + + + |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M + + |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 5| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 4| 3| 8| 3| 0| 3| 3| 3| 3| 4|
| 6| 6| 5| 6| 3| 6| 7| 7| 5| 7| 5| 7| 8| 8| 8| 3| 8| 7| 0| 2| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Adenocarcinoma, Metastatic, | |
Harderian Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + |
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenocarcinoma | |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4| |
| 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 12 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 12 |
Leiomyosarcoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 11 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 12 |
Adenocarcinoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X X | 3 |
Hepatocellular Adenoma | X X X X X X X X X X| 20 |
Hepatocellular Adenoma, Multiple | X X X X | 5 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Mixed | X X X | 5 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 12 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 12 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4| |
| 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 14 |
Pars Distalis, Adenoma | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + | 25 |
Cystadenoma | X | 1 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + +| 33 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
Femoral, Lymphoma Malignant | | |
Histiocytic | | 1 |
Femoral, Lymphoma Malignant Mixed | X | 2 |
Vertebral, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 15 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mandibular, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 4 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 23 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4| |
| 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X X X | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + | 11 |
Lymphoma Malignant Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + | 12 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 13 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 13 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Adenocarcinoma | X | 1 |
Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 14 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + M + | 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 4| 4| 4| 4| 4| |
| 0| 0| 0| 9| 3| 3| 4| 3| 3| 4| 4| 4| 4| 5| 5| 5| 0| 5| 6| 6| 6| 6| 6| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Gallbladder | A + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | A + + A + |
__________________________________________________________________________|
Intestine Small | A + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + |
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Mesentery | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | A + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | A + + + + |
__________________________________________________________________________|
Stomach | + A + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | A + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | A + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | A + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + |
__________________________________________________________________________|
Pituitary Gland | A + + + A + + M + +|
Lymphoma Malignant Mixed | X|
Pars Distalis, Adenoma | X X X X|
__________________________________________________________________________|
Thyroid Gland | A + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + A + + + + + + + + + + + + +|
Cystadenoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + A + + + + + + + + + + + |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + + |
Femoral, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | A + + + + + + + |
Deep Cervical, Lymphoma Malignant | |
Mixed | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | X |
Mandibular, Adenocarcinoma, | |
Metastatic, Harderian Gland | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | X |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinal, Lymphoma Malignant Mixed| X |
Mediastinal, Osteosarcoma, | |
Metastatic, Uncertain Primary | |
Site | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X X|
__________________________________________________________________________|
Thymus | A + + A + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
__________________________________________________________________________|
Skin | + + + + + |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 3| 3| 9| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
| 6| 6| 4| 6| 6| 7| 7| 7| 0| 2| 7| 8| 8| 8| 5| 8| 9| 9| 6| 9| 9| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
200 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + |
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + |
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenocarcinoma | X X |
Adenoma | X |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Urinary Bladder | A + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7| |
| 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + +| 12 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + +| 11 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + M| 11 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X X X X | 8 |
Hepatocellular Adenoma, Multiple | X X| 5 |
Lymphoma Malignant Mixed | X X X X | 6 |
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + +| 11 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + + +| 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 16 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 13 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + +| 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + +| 11 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + +| 11 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + +| 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7| |
| 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M M + + +| 15 |
Lymphoma Malignant Mixed | | 1 |
Pars Distalis, Adenoma | X X X X | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + +| 30 |
Cystadenoma | | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 32 |
Sarcoma Stromal | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + +| 11 |
Femoral, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 20 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | X | 1 |
Inguinal, Lymphoma Malignant Mixed | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 2 |
Mandibular, Adenocarcinoma, | | |
Metastatic, Harderian Gland | | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mandibular, Lymphoma Malignant Mixed | X X X | 4 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X X X | 5 |
Mediastinal, Osteosarcoma, | | |
Metastatic, Uncertain Primary | | |
Site | | 1 |
Renal, Lymphoma Malignant Mixed | X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 9 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7| |
| 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 27 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X X | 11 |
__________________________________________________________________________|____________|
Thymus | + + + + + + +| 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + +| 13 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + +| 13 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Mixed | X X X | 4 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + +| 12 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 4| 6| 4| 4| 4| 4| 4| 4| 4| 8| 3| 1| 4| 4| 4| 4| 4| 7| 4| 4| 4| 8| 4| 4| 7| |
| 0| 5| 3| 3| 3| 3| 4| 4| 4| 0| 0| 7| 4| 5| 5| 5| 5| 4| 6| 6| 6| 9| 6| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
200 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Adenocarcinoma | | 2 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + +| 12 |
Lymphoma Malignant Mixed | X | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + +| 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|
| 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + + + A + + M + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X X X X|
Hepatocellular Adenoma | X X X X X X X X X X|
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Mast Cell Tumor NOS | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|
| 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mast Cell Tumor NOS | X |
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + I + + + + M + + + + + + M + + + M + + + + M|
Lymphoma Malignant Lymphocytic | |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Teratoma | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|
| 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + I + + + +|
Femoral, Lymphoma Malignant | |
Lymphocytic | |
Femoral, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + M +|
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + I + + M + + + + + + + M + + + + M + + + + + M|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + + + + M M + + + M + + + M + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + I + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 2| 3| 3| 0| 3| 3| 3| 3| 4| 4| 4|
| 6| 6| 6| 6| 7| 7| 7| 7| 0| 3| 8| 7| 8| 8| 4| 8| 9| 0| 7| 9| 9| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4| |
| 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + + + + + + + + M + + + + + + +| 45 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X X | 10 |
Hepatocellular Adenoma | X X X X X X X X X| 19 |
Hepatocellular Adenoma, Multiple | X X X X X | 7 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4| |
| 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mast Cell Tumor NOS | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Mast Cell Tumor NOS | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + | 12 |
Peridontal Tissue, Lymphoma | | |
Malignant Undifferentiated Cell | | |
Type | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + I + + + + + + +| 44 |
Lymphoma Malignant Lymphocytic | X | 1 |
Pars Distalis, Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Follicular Cell, Adenoma | X X X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4| |
| 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Teratoma | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Polyp Stromal | X| 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Femoral, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Mandibular, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 6 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4| |
| 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + + M M + + + + + + + + + + + + + + + + +| 42 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + + + + + M + M M + + + + + M +| 39 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 3| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 3| 4| |
| 0| 3| 3| 3| 3| 0| 4| 2| 4| 7| 4| 4| 5| 5| 5| 5| 7| 9| 6| 6| 6| 6| 6| 7| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 4 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|
| 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Tooth | + + + + + + |
Peridontal Tissue, Lymphoma | |
Malignant Histiocytic | |
Peridontal Tissue, Lymphoma | |
Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|
| 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + I A + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + I A + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M A + + + + + + +|
Lymphoma Malignant Histiocytic | |
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + M M + + + I + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Follicular Cell, Adenoma | X |
Follicular Cell, Adenoma, Multiple | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
Luteoma | X |
Lymphoma Malignant Histiocytic | |
Periovarian Tissue, Lymphoma | |
Malignant Histiocytic | X |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Vagina | |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Lymphoma Malignant | |
Histiocytic | X |
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
Femoral, Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|
| 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X X |
Mandibular, Lymphoma Malignant Mixed | X X X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + + M + + + + + M + + M M M + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 4| 4| 4| 4|
| 1| 6| 6| 6| 6| 7| 8| 7| 6| 7| 7| 8| 8| 8| 8| 3| 9| 7| 9| 9| 9| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Mediastinum, Hepatocellular | |
Carcinoma, Metastatic, Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2| |
| 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M + A + + + + + + + + + + + + + M + + + + + + +| 45 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + M + + + + + + + + +| 47 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X X X X X X | 9 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | X X X X X X X X X | 16 |
Hepatocellular Adenoma, Multiple | X X | 6 |
Lymphoma Malignant Histiocytic | X X X| 5 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + +| 6 |
Lymphoma Malignant Histiocytic | X X X X| 5 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X X| 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Tooth | + + + | 9 |
Peridontal Tissue, Lymphoma | | |
Malignant Histiocytic | X | 1 |
Peridontal Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2| |
| 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 1 |
Pheochromocytoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + M + + + M + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | I + I + + + + + + + + + + I + + + M + + + + + I +| 41 |
Pars Distalis, Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
Follicular Cell, Adenoma | X | 2 |
Follicular Cell, Adenoma, Multiple | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + I + + + + + + +| 49 |
Cystadenoma | | 2 |
Luteoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Histiocytic | X | 2 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2| |
| 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Lymphoma Malignant | | |
Histiocytic | | 1 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Femoral, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | X X | 2 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X| 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mandibular, Lymphoma Malignant Mixed | | 3 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X| 2 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + +| 6 |
Lymphoma Malignant Histiocytic | X X| 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X X X| 4 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Thymus | + + + + M M + + + + + + + M + + + + + + + + + + M| 45 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + M M + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2| |
| 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 2 |
Lymphoma Malignant Histiocytic | X X| 4 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Mediastinum, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X| 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 6| 4| 8| 0| 4| 4| 4| 8| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 4| 2| 4| 2| |
| 3| 3| 3| 4| 3| 6| 9| 3| 4| 4| 4| 4| 4| 0| 9| 5| 5| 5| 5| 6| 6| 6| 9| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
600 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Histiocytic | X X X X| 6 |
Lymphoma Malignant Lymphocytic | X X | 5 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X|
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X |
Lymphoma Malignant Histiocytic | X X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corticomedullary Junction, | |
Hepatocellular Carcinoma, | |
Metastatic, Liver | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + |
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hemangiosarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant | |
Histiocytic | X |
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Fibrosarcoma, Metastatic,| |
Skin | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + |
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemangiosarcoma | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Thymus | + M + + + + + + M + + + + + M + + + + + M + M + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 8| 3| 0| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 9| 4| 4| 4| 5| 5| 5| 0| 5| 6| 0| 6| 9| 8| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + + |
Adenocarcinoma | |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + + + I + + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 4 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | X X X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X X X X X X | 14 |
Hepatocellular Adenoma, Multiple | X | 5 |
Lymphoma Malignant Histiocytic | | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + +| 36 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corticomedullary Junction, | | |
Hepatocellular Carcinoma, | | |
Metastatic, Liver | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + I + I + + + + I + M + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 5 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 9 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hemangiosarcoma | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mandibular, Fibrosarcoma, Metastatic,| | |
Skin | X | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mandibular, Lymphoma Malignant Mixed | X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Pancreatic, Lymphoma Malignant Mixed | X | 2 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 22 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X X X | 4 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X X | 4 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Thymus | M + + I + + + + M I M + + + + M + + + + + + M M +| 37 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 6 |
Alveolar/Bronchiolar Carcinoma | X X| 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X | 6 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 9 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 7| 4| 4| 7| 4| 4| 6| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 3| 1| 1| 3| 1| 1| 8| 2| 2| 7| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 0| 1| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Adenoma | X X X | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | X X X X | 5 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Gallbladder | A + M + M |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small | A + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X|
Hepatocellular Adenoma, Multiple | X X X X X X X |
Hepatocholangiocarcinoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Mesentery | + |
Hepatocholangiocarcinoma, Metastatic | |
__________________________________________________________________________|
Pancreas | A + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + M + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + M + |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Femoral, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Deep Cervical, Carcinoma, Metastatic,| |
Ear | X |
Lumbar, Lymphoma Malignant Mixed | X |
Mandibular, Lymphoma Malignant | |
Histiocytic | X |
Mandibular, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | A M + + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | A |
__________________________________________________________________________|
Skin | + A + + + + |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + |
Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Carcinoma, Metastatic, Ear | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Hepatocholangiocarcinoma, Metastatic | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Basal Cell Carcinoma | X |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 4| 4| 5| 6| 5| 0| 5| 5| 6| 6| 6| 6| 7| 6| 7| 7| 3| 7| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4| |
| 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + | 11 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 13 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + | 12 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + M | 11 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + | 12 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Multiple | X | 2 |
Hepatocellular Carcinoma | X X X | 10 |
Hepatocellular Carcinoma, Multiple | X X X| 4 |
Hepatocellular Adenoma | X X X X X X X X| 11 |
Hepatocellular Adenoma, Multiple | X X X X X | 12 |
Hepatocholangiocarcinoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Hepatocholangiocarcinoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 13 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 13 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 16 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4| |
| 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 14 |
Adenoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 13 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + | 13 |
__________________________________________________________________________|____________|
Pituitary Gland | M + A + + + + + + | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 14 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 14 |
Femoral, Lymphoma Malignant | | |
Histiocytic | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 30 |
Deep Cervical, Carcinoma, Metastatic,| | |
Ear | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 2 |
Mandibular, Lymphoma Malignant Mixed | X X | 2 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4| |
| 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 22 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 21 |
Hemangiosarcoma | X X | 2 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X X X X | 7 |
__________________________________________________________________________|____________|
Thymus | M + I + + + M + + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 15 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 30 |
Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 19 |
Alveolar/Bronchiolar Adenoma | X X X X X | 8 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X | 2 |
Carcinoma, Metastatic, Ear | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Hepatocholangiocarcinoma, Metastatic | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 7| 9| 4| 7| 4| 4| 4| 9| 4| 4| 4| 4| 4| 3| 4| 4| 4| 5| 4| 4| 0| 4| 3| 4| 4| |
| 6| 1| 1| 5| 1| 1| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 2| 3| 4| 5| 4| 6| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Basal Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Eye | + +| 3 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 16 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X X X X X | 8 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|
| 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | M + + + M + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | |
Hepatoblastoma, Multiple | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | A + + + + + + + |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | A + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + |
__________________________________________________________________________|
Tooth | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Cholangiocarcinoma, Metastatic, Liver| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | A + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | A + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | A + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | A + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | M I + I M M M I |
Pars Distalis, Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|
| 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | +|
__________________________________________________________________________|
Testes | + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + |
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + + + + + + + + +|
Mediastinal, Cholangiocarcinoma, | |
Metastatic, Liver | |
Mediastinal, Lymphoma Malignant Mixed| X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | M + M + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 8| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 0| 3|
| 4| 5| 4| 4| 4| 5| 5| 3| 5| 5| 6| 6| 4| 6| 6| 6| 6| 7| 4| 7| 7| 6| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multiple | X |
Cholangiocarcinoma, Metastatic, Liver| |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
__________________________________________________________________________|
Nose | + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenocarcinoma | |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| |
| 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 12 |
__________________________________________________________________________|____________|
Gallbladder | + + M A | 8 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A A | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + | 17 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cholangiocarcinoma | X | 1 |
Hepatoblastoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X X X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X X X X X X | 10 |
Hepatocellular Adenoma, Multiple | X X | 6 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + A + | 11 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + A + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A | 11 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A | 9 |
__________________________________________________________________________|____________|
Tooth | + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 12 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Cholangiocarcinoma, Metastatic, Liver| X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| |
| 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + I + | 4 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 11 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 12 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + | 12 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + +| 32 |
Mediastinal, Cholangiocarcinoma, | | |
Metastatic, Liver | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + +| 20 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + A + + | 18 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Thymus | M M + M | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + | 13 |
Subcutaneous Tissue, Lipoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| |
| 4| 8| 8| 1| 1| 1| 1| 2| 2| 2| 2| 3| 2| 3| 3| 3| 4| 8| 4| 4| 4| 9| 4| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 12 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + +| 19 |
Alveolar/Bronchiolar Adenoma | | 5 |
Alveolar/Bronchiolar Carcinoma | X| 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 2 |
Cholangiocarcinoma, Metastatic, Liver| X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 3 |
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenocarcinoma | X | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 12 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X X X X|
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + A + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + +|
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + A + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + A + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + A + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + +|
Pars Intermedia, Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + +|
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Testes | + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + +|
Femoral, Lymphoma Malignant | |
Histiocytic | |
Femoral, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Mandibular, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + A + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + M M + + M|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 8| 2| 3| 3| 3| 1|
| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 2| 6| 6| 6| 8| 7| 7| 7| 5| 9| 7| 8| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4| |
| 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | A + + + A + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + A + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + A + + +| 11 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + A + + | 10 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma, Multiple | X X X | 4 |
Hepatocellular Carcinoma | X X X X X X| 11 |
Hepatocellular Carcinoma, Multiple | X X X X | 7 |
Hepatocellular Adenoma | X X X | 10 |
Hepatocellular Adenoma, Multiple | X X X X X X X | 13 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 13 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 13 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 13 |
Hemangiosarcoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 12 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4| |
| 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M I I + | 10 |
Pars Intermedia, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 13 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 13 |
Femoral, Lymphoma Malignant | | |
Histiocytic | X X | 2 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 27 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mandibular, Lymphoma Malignant Mixed | X| 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X| 1 |
Pancreatic, Lymphoma Malignant Mixed | X| 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 94
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4| |
| 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + +| 16 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X| 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 20 |
Hemangiosarcoma | X X | 3 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X| 3 |
__________________________________________________________________________|____________|
Thymus | M M M + + + + | 7 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 14 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + +| 30 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 13 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 21 |
Alveolar/Bronchiolar Adenoma | X X X X | 5 |
Alveolar/Bronchiolar Carcinoma | X X X | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 5 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 95
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 6| 4| 4| 7| 3| 4| 8| 4| 4| 4| 4| |
| 8| 8| 3| 4| 1| 1| 1| 1| 2| 2| 0| 2| 2| 3| 0| 3| 3| 4| 2| 3| 8| 4| 4| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 13 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X| 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 96
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|
| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M I + A M + M|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M A + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X X X X|
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + +|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|
| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + I + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant Mixed | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | M + I + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 8| 3| 3| 4| 3| 3| 3| 3| 1| 2| 3| 3| 3| 8|
| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 0| 6| 6| 3| 6| 7| 7| 7| 3| 0| 7| 8| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Harderian Gland | X |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Adenocarcinoma | X |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4| |
| 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + M | 10 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 14 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 16 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma, Multiple | X | 1 |
Hepatoblastoma | X | 1 |
Hepatocellular Carcinoma | X X X X X X X | 14 |
Hepatocellular Carcinoma, Multiple | X X X | 4 |
Hepatocellular Adenoma | X X X X X X X X X | 15 |
Hepatocellular Adenoma, Multiple | X X| 5 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 17 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 15 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 100
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4| |
| 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + M | 14 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 18 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 31 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X | 2 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + +| 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 101
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4| |
| 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X| 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 25 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X| 4 |
__________________________________________________________________________|____________|
Thymus | + + M M + + + M + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 20 |
Lymphoma Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + +| 37 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 18 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 20 |
Adenocarcinoma, Metastatic, | | |
Harderian Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X X | 3 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X | 4 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenocarcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 102
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 5| 7| |
DAY ON TEST | 3| 3| 3| 4| 6| 2| 4| 4| 7| 4| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 3| 6| 6| 4| |
| 8| 8| 8| 1| 6| 3| 9| 1| 3| 1| 0| 1| 2| 2| 2| 2| 3| 7| 3| 3| 3| 2| 0| 4| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 18 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Renal Tubule, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 18 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 4 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X| 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 103
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|
| 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Gallbladder | + M A M + |
__________________________________________________________________________|
Intestine Large | + + + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X |
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X|
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X |
Lymphoma Malignant Histiocytic | X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Pancreas | + + A + + |
__________________________________________________________________________|
Salivary Glands | + + A + + |
__________________________________________________________________________|
Stomach | + + A + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + |
Adenoma | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + A + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + A + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + A + + |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + |
__________________________________________________________________________|
Parathyroid Gland | M M + + + |
__________________________________________________________________________|
Pituitary Gland | + M A + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|
| 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + A + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Hemangiosarcoma | |
__________________________________________________________________________|
Prostate | + + A + + |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + A + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + + |
__________________________________________________________________________|
Lymph Node | + M + + + A + + + + + +|
Mediastinal, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Spleen | + + + + + A + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + A M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X|
Lymphoma Malignant Histiocytic | X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 2| 8| 3| 3|
| 4| 4| 4| 4| 2| 5| 5| 5| 9| 5| 6| 6| 2| 6| 6| 7| 7| 0| 7| 7| 8| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Urinary Bladder | + + A + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X X|
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 4| 3| 7| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| |
| 8| 1| 1| 3| 8| 1| 3| 1| 2| 2| 2| 2| 3| 3| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + +| 10 |
__________________________________________________________________________|____________|
Gallbladder | M A + + +| 5 |
__________________________________________________________________________|____________|
Intestine Large | + A + + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + +| 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + +| 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + +| 8 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + +| 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A M +| 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A +| 8 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Multiple | | 1 |
Hepatoblastoma | X | 1 |
Hepatocellular Carcinoma | X X X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X X| 3 |
Hepatocellular Adenoma | X X X X | 11 |
Hepatocellular Adenoma, Multiple | X X X | 8 |
Lymphoma Malignant Histiocytic | X | 2 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Pancreas | + A + + +| 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + +| 9 |
__________________________________________________________________________|____________|
Stomach | + + + + +| 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + +| 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + +| 9 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + +| 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + +| 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + +| 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + +| 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + +| 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + +| 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 107
NTP Experiment-Test: 05075-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/09/97
Route: DOSED FEED Time: 14:35:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 4| 4| 3| 7| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| |
| 8| 1| 1| 3| 8| 1| 3| 1| 2| 2| 2| 2| 3| 3| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M| 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + +| 9 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + +| 9 |
__________________________________________________________________________|____________|
Preputial Gland | + + + +| 8 |
Hemangiosarcoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + +| 9 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + +| 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + +| 9 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 23 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + +| 15 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Spleen | + A + + + + + +| 17 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
_________________________________