TDMS Study 05075-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIPHENYLHYDANTOIN DATE: 09/09/94
EXPERIMENT: 05075 TEST: 02 TIME: 16:07:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 55765
PATHOLOGIST: S. GRUMBEIN S. EUSTIS CAS: 57-41-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIPHENYLHYDANTOIN DATE: 09/09/94
EXPERIMENT: 05075 TEST: 02 TIME: 16:07:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 55765
PATHOLOGIST: S. GRUMBEIN S. EUSTIS CAS: 57-41-0
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIPHENYLHYDANTOIN DATE: 09/09/94
EXPERIMENT: 05075 TEST: 02 TIME: 16:07:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 55765
PATHOLOGIST: S. GRUMBEIN S. EUSTIS CAS: 57-41-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DIPHENYLHYDANTOIN
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hemangiosarcoma
Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Harderian Gland Carcinoma or Adenoma
Liver Hemangiosarcoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Spleen Hemangiosarcoma
Stomach, Forestomach Squamous Cell Papilloma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/64 (2%) 0/11 (0%) 0/37 (0%) 1/94 (1%) | 4/64 (6%) 1/14 (7%) 1/36 (3%) 2/98 (2%) |
|ADJUSTED (b) | 1.1% 0.0% 0.0% 1.4% | 7.9% 0.0% 0.0% 2.6% |
|TERMINAL (d) | 0/40 (0%) 0/1 (0%) 0/2 (0%) 1/74 (1%) | 2/36 (6%) 0/0 0/0 2/76 (3%) |
|FIRST INCIDENCE (DAYS) | 609 --- --- 734 (T) | 607 682 675 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.694N P=0.660N P=0.428N P=0.700N | P=0.095N P=0.727 P=0.332N P=0.139N |
|INCIDENTAL TUMOR | P=0.687 P=0.617N P=0.412N P=0.767N | P=0.101N P=0.696 P=0.354N P=0.155N |
|LOGISTIC REGRESSION | P=0.676N P=0.703N P=0.524N P=0.671N | P=0.080N P=0.601 P=0.461N P=0.142N |
|COCHRAN-ARMITAGE | P=0.676N | P=0.127N |
|FISHER EXACT | P=0.853N P=0.634N P=0.648N | P=0.639 P=0.405N P=0.168N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/64 (2%) 0/11 (0%) 0/37 (0%) 1/94 (1%) | 6/64 (9%) 1/14 (7%) 1/36 (3%) 3/98 (3%) |
|ADJUSTED (b) | 1.1% 0.0% 0.0% 1.4% | 11.7% 0.0% 0.0% 3.9% |
|TERMINAL (d) | 0/40 (0%) 0/1 (0%) 0/2 (0%) 1/74 (1%) | 3/36 (8%) 0/0 0/0 3/76 (4%) |
|FIRST INCIDENCE (DAYS) | 609 --- --- 734 (T) | 607 682 675 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.694N P=0.660N P=0.428N P=0.700N | P=0.049N* P=0.577N P=0.155N P=0.065N |
|INCIDENTAL TUMOR | P=0.687 P=0.617N P=0.412N P=0.767N | P=0.051N P=0.707N P=0.161N P=0.074N |
|LOGISTIC REGRESSION | P=0.676N P=0.703N P=0.524N P=0.671N | P=0.041N* P=0.698 P=0.271N P=0.063N |
|COCHRAN-ARMITAGE | P=0.676N | P=0.085N |
|FISHER EXACT | P=0.853N P=0.634N P=0.648N | P=0.632N P=0.207N P=0.088N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/64 (3%) 0/11 (0%) 0/40 (0%) 0/100 (0%) | 3/64 (5%) 0/15 (0%) 0/36 (0%) 0/99 (0%) |
|ADJUSTED (b) | 3.6% 0.0% 0.0% 0.0% | 3.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/40 (3%) 0/1 (0%) 0/3 (0%) 0/78 (0%) | 0/36 (0%) 0/1 (0%) 0/0 0/76 (0%) |
|FIRST INCIDENCE (DAYS) | 650 --- --- --- | 607 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.123N P=0.619N P=0.387N P=0.170N | P=0.093N P=0.275N P=0.053N P=0.107N |
|INCIDENTAL TUMOR | P=0.130N P=0.740N P=0.389N P=0.205N | P=0.097N P=0.320N P=0.058N P=0.121N |
|LOGISTIC REGRESSION | P=0.122N P=0.711N P=0.406N P=0.149N | P=0.060N P=0.444N P=0.230N P=0.077N |
|COCHRAN-ARMITAGE | P=0.124N | P=0.055N |
|FISHER EXACT | P=0.726N P=0.376N P=0.151N | P=0.527N P=0.258N P=0.059N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 7/100 (7%) 1/50 (2%) 7/148 (5%) 6/100 (6%) | 4/100 (4%) 2/50 (4%) 6/150 (4%) 1/100 (1%) |
|ADJUSTED (b) | 9.2% 2.6% 6.4% 7.7% | 5.6% 5.7% 4.9% 1.3% |
|TERMINAL (d) | 7/76 (9%) 1/39 (3%) 7/109 (6%) 6/78 (8%) | 3/70 (4%) 2/35 (6%) 4/113 (4%) 1/77 (1%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) 734 (T) 734 (T) | 726 736 (T) 625 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.529 P=0.175N P=0.337N P=0.481N | P=0.108N P=0.669 P=0.581N P=0.155N |
|INCIDENTAL TUMOR | P=0.529 P=0.175N P=0.337N P=0.481N | P=0.122N P=0.626 P=0.628N P=0.161N |
|LOGISTIC REGRESSION | P=0.529 P=0.175N P=0.337N P=0.481N | P=0.114N P=0.670 P=0.610N P=0.146N |
|COCHRAN-ARMITAGE | P=0.510 | P=0.131N |
|FISHER EXACT | P=0.188N P=0.312N P=0.500N | P=0.683N P=0.621N P=0.184N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 1/50 (2%) 1/148 (1%) 1/100 (1%) | 4/100 (4%) 0/50 (0%) 4/150 (3%) 0/100 (0%) |
|ADJUSTED (b) | 1.3% 2.6% 0.8% 1.3% | 5.3% 0.0% 3.4% 0.0% |
|TERMINAL (d) | 1/76 (1%) 1/39 (3%) 0/109 (0%) 0/78 (0%) | 3/70 (4%) 0/35 (0%) 3/113 (3%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) 645 723 | 491 --- 662 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.606N P=0.605 P=0.677N P=0.753N | P=0.075N P=0.188N P=0.376N P=0.056N |
|INCIDENTAL TUMOR | P=0.653N P=0.605 P=0.673N P=0.719 | P=0.094N P=0.171N P=0.432N P=0.085N |
|LOGISTIC REGRESSION | P=0.623N P=0.605 P=0.665N P=0.762 | P=0.091N P=0.186N P=0.421N P=0.074N |
|COCHRAN-ARMITAGE | P=0.613N | P=0.088N |
|FISHER EXACT | P=0.557 P=0.645N P=0.751N | P=0.194N P=0.405N P=0.061N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 2/50 (4%) 8/148 (5%) 7/100 (7%) | 8/100 (8%) 2/50 (4%) 10/150 (7%) 1/100 (1%) |
|ADJUSTED (b) | 10.5% 5.1% 7.2% 8.9% | 10.8% 5.7% 8.3% 1.3% |
|TERMINAL (d) | 8/76 (11%) 2/39 (5%) 7/109 (6%) 6/78 (8%) | 6/70 (9%) 2/35 (6%) 7/113 (6%) 1/77 (1%) |
|FIRST INCIDENCE (DAYS) | 734 (T) 734 (T) 645 723 | 491 736 (T) 625 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.554 P=0.268N P=0.312N P=0.478N | P=0.019N* P=0.284N P=0.379N P=0.015N* |
|INCIDENTAL TUMOR | P=0.537 P=0.268N P=0.310N P=0.502N | P=0.026N* P=0.299N P=0.453N P=0.022N* |
|LOGISTIC REGRESSION | P=0.548 P=0.268N P=0.305N P=0.473N | P=0.023N* P=0.284N P=0.432N P=0.018N* |
|COCHRAN-ARMITAGE | P=0.535 | P=0.026N* |
|FISHER EXACT | P=0.291N P=0.287N P=0.500N | P=0.291N P=0.435N P=0.017N* |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Heart |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/64 (2%) 0/12 (0%) 2/40 (5%) 0/99 (0%) | 0/66 (0%) 0/15 (0%) 0/38 (0%) 0/100 (0%) |
|ADJUSTED (b) | 2.5% 0.0% 1.6% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/40 (3%) 0/1 (0%) 0/2 (0%) 0/78 (0%) | 0/36 (0%) 0/0 0/1 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) --- 633 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.276N P=0.999N P=0.354 P=0.367N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.323N P=0.999N P=0.369 P=0.367N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.224N P=0.999N P=0.281 P=0.367N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.225N | (e) |
|FISHER EXACT | P=0.842N P=0.328 P=0.393N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 0/50 (0%) 7/148 (5%) 4/99 (4%) | 3/97 (3%) 2/50 (4%) 0/149 (0%) 0/100 (0%) |
|ADJUSTED (b) | 10.0% 0.0% 5.8% 5.0% | 4.2% 5.2% 0.0% 0.0% |
|TERMINAL (d) | 6/76 (8%) 0/39 (0%) 3/109 (3%) 3/78 (4%) | 2/69 (3%) 1/35 (3%) 0/113 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 642 --- 633 710 | 682 633 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.323N P=0.048N* P=0.237N P=0.179N | P=0.040N* P=0.568 P=0.051N P=0.103N |
|INCIDENTAL TUMOR | P=0.411N P=0.053N P=0.211N P=0.234N | P=0.045N* P=0.576 P=0.051N P=0.111N |
|LOGISTIC REGRESSION | P=0.352N P=0.048N* P=0.211N P=0.207N | P=0.045N* P=0.574 P=0.054N P=0.108N |
|COCHRAN-ARMITAGE | P=0.338N | P=0.046N* |
|FISHER EXACT | P=0.035N* P=0.214N P=0.191N | P=0.555 P=0.060N P=0.117N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/50 (2%) 2/148 (1%) 0/99 (0%) | 0/97 (0%) 0/50 (0%) 0/149 (0%) 1/100 (1%) |
|ADJUSTED (b) | 0.0% 2.6% 1.8% 0.0% | 0.0% 0.0% 0.0% 1.3% |
|TERMINAL (d) | 0/76 (0%) 1/39 (3%) 1/109 (1%) 0/78 (0%) | 0/69 (0%) 0/35 (0%) 0/113 (0%) 1/77 (1%) |
|FIRST INCIDENCE (DAYS) | --- 734 (T) 697 --- | --- --- --- 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.453N P=0.367 P=0.325 (e) | P=0.243 (e) (e) P=0.522 |
|INCIDENTAL TUMOR | P=0.480N P=0.367 P=0.327 (e) | P=0.243 (e) (e) P=0.522 |
|LOGISTIC REGRESSION | P=0.468N P=0.367 P=0.325 (e) | P=0.243 (e) (e) P=0.522 |
|COCHRAN-ARMITAGE | P=0.464N | P=0.232 |
|FISHER EXACT | P=0.333 P=0.355 (e) | (e) (e) P=0.508 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 42/100 (42%) 16/50 (32%) 62/148 (42%) 53/99 (54%) | 16/97 (16%) 11/50 (22%) 50/149 (34%) 48/100 (48%)|
|ADJUSTED (b) | 49.6% 38.0% 51.1% 63.0% | 21.4% 30.2% 41.9% 52.5% |
|TERMINAL (d) | 34/76 (45%) 13/39 (33%) 51/109 (47%) 47/78 (60%) | 12/69 (17%) 10/35 (29%) 44/113 (39%) 34/77 (44%) |
|FIRST INCIDENCE (DAYS) | 540 584 535 612 | 607 587 660 503 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * P=0.151N P=0.482 P=0.109 | P<0.001 ** P=0.257 P=0.006 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.006 ** P=0.180N P=0.513 P=0.035 * | P<0.001 ** P=0.241 P=0.005 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.008 ** P=0.173N P=0.517 P=0.040 * | P<0.001 ** P=0.255 P=0.005 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.015 * | P<0.001 ** |
|FISHER EXACT | P=0.157N P=0.545N P=0.068 | P=0.274 P=0.002 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/100 (27%) 13/50 (26%) 50/148 (34%) 27/99 (27%) | 1/97 (1%) 4/50 (8%) 8/149 (5%) 21/100 (21%)|
|ADJUSTED (b) | 30.7% 28.4% 38.7% 31.9% | 1.0% 9.6% 6.8% 25.4% |
|TERMINAL (d) | 17/76 (22%) 7/39 (18%) 32/109 (29%) 21/78 (27%) | 0/69 (0%) 1/35 (3%) 6/113 (5%) 17/77 (22%) |
|FIRST INCIDENCE (DAYS) | 463 495 481 564 | 486 587 675 570 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.467N P=0.517N P=0.151 P=0.537N | P<0.001 ** P=0.040 * P=0.092 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.308 P=0.551N P=0.155 P=0.336 | P<0.001 ** P=0.125 P=0.068 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.260 P=0.467N P=0.139 P=0.504 | P<0.001 ** P=0.036 * P=0.074 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.513N | P<0.001 ** |
|FISHER EXACT | P=0.530N P=0.160 P=0.546 | P=0.046 * P=0.072 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/100 (27%) 13/50 (26%) 51/148 (34%) 27/99 (27%) | 1/97 (1%) 4/50 (8%) 8/149 (5%) 22/100 (22%)|
|ADJUSTED (b) | 30.7% 28.4% 39.5% 31.9% | 1.0% 9.6% 6.8% 26.6% |
|TERMINAL (d) | 17/76 (22%) 7/39 (18%) 33/109 (30%) 21/78 (27%) | 0/69 (0%) 1/35 (3%) 6/113 (5%) 18/77 (23%) |
|FIRST INCIDENCE (DAYS) | 463 495 481 564 | 486 587 675 570 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.461N P=0.517N P=0.129 P=0.537N | P<0.001 ** P=0.040 * P=0.092 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.314 P=0.551N P=0.130 P=0.336 | P<0.001 ** P=0.125 P=0.068 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.267 P=0.467N P=0.149 P=0.504 | P<0.001 ** P=0.036 * P=0.074 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.507N | P<0.001 ** |
|FISHER EXACT | P=0.530N P=0.135 P=0.546 | P=0.046 * P=0.072 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 62/100 (62%) 25/50 (50%) 95/148 (64%) 67/99 (68%) | 17/97 (18%) 13/50 (26%) 56/149 (38%) 64/100 (64%)|
|ADJUSTED (b) | 65.8% 53.0% 71.1% 76.1% | 22.2% 33.5% 46.1% 67.9% |
|TERMINAL (d) | 44/76 (58%) 17/39 (44%) 71/109 (65%) 57/78 (73%) | 12/69 (17%) 10/35 (29%) 48/113 (42%) 47/77 (61%) |
|FIRST INCIDENCE (DAYS) | 463 495 481 564 | 486 587 660 503 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.203 P=0.145N P=0.338 P=0.362 | P<0.001 ** P=0.150 P=0.002 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.016 * P=0.132N P=0.373 P=0.065 | P<0.001 ** P=0.183 P=0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.011 * P=0.096N P=0.344 P=0.127 | P<0.001 ** P=0.155 P=0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.100 | P<0.001 ** |
|FISHER EXACT | P=0.110N P=0.413 P=0.245 | P=0.161 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 62/100 (62%) 25/50 (50%) 95/148 (64%) 67/99 (68%) | 17/97 (18%) 13/50 (26%) 56/149 (38%) 64/100 (64%)|
|ADJUSTED (b) | 65.8% 53.0% 71.1% 76.1% | 22.2% 33.5% 46.1% 67.9% |
|TERMINAL (d) | 44/76 (58%) 17/39 (44%) 71/109 (65%) 57/78 (73%) | 12/69 (17%) 10/35 (29%) 48/113 (42%) 47/77 (61%) |
|FIRST INCIDENCE (DAYS) | 463 495 481 564 | 486 587 660 503 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.203 P=0.145N P=0.338 P=0.362 | P<0.001 ** P=0.150 P=0.002 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.016 * P=0.132N P=0.373 P=0.065 | P<0.001 ** P=0.183 P=0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.011 * P=0.096N P=0.344 P=0.127 | P<0.001 ** P=0.155 P=0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.100 | P<0.001 ** |
|FISHER EXACT | P=0.110N P=0.413 P=0.245 | P=0.161 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/69 (20%) 5/19 (26%) 10/63 (16%) 11/99 (11%) | 7/70 (10%) 1/20 (5%) 4/41 (10%) 3/100 (3%) |
|ADJUSTED (b) | 23.4% 40.4% 29.8% 14.1% | 17.5% 2.7% 75.2% 3.9% |
|TERMINAL (d) | 8/45 (18%) 3/8 (38%) 7/25 (28%) 11/78 (14%) | 7/40 (18%) 0/5 (0%) 3/4 (75%) 3/77 (4%) |
|FIRST INCIDENCE (DAYS) | 491 574 649 734 (T) | 736 (T) 690 636 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.019N* P=0.455 P=0.467N P=0.062N | P=0.007N** P=0.665N P=0.018 * P=0.016N* |
|INCIDENTAL TUMOR | P=0.029N* P=0.383 P=0.464N P=0.113N | P=0.008N** P=0.705 P=0.015 * P=0.016N* |
|LOGISTIC REGRESSION | P=0.025N* P=0.352 P=0.475N P=0.081N | P=0.008N** P=0.692N P=0.225 P=0.016N* |
|COCHRAN-ARMITAGE | P=0.042N* | P=0.052N |
|FISHER EXACT | P=0.389 P=0.334N P=0.078N | P=0.431N P=0.621N P=0.058N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/69 (13%) 4/19 (21%) 15/63 (24%) 6/99 (6%) | 1/70 (1%) 1/20 (5%) 3/41 (7%) 0/100 (0%) |
|ADJUSTED (b) | 17.4% 39.1% 60.0% 7.7% | 2.5% 20.0% 26.1% 0.0% |
|TERMINAL (d) | 7/45 (16%) 3/8 (38%) 15/25 (60%) 6/78 (8%) | 1/40 (3%) 1/5 (20%) 1/4 (25%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 633 713 734 (T) 734 (T) | 736 (T) 736 (T) 565 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** P=0.216 P=0.003 ** P=0.065N | P=0.101N P=0.264 P=0.086 P=0.369N |
|INCIDENTAL TUMOR | P=0.003N** P=0.201 P=0.003 ** P=0.083N | P=0.120N P=0.264 P=0.056 P=0.369N |
|LOGISTIC REGRESSION | P=0.003N** P=0.158 P=0.007 ** P=0.088N | P=0.129N P=0.264 P=0.129 P=0.369N |
|COCHRAN-ARMITAGE | P=0.019N* | P=0.141N |
|FISHER EXACT | P=0.294 P=0.084 P=0.100N | P=0.397 P=0.142 P=0.412N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/69 (32%) 8/19 (42%) 23/63 (37%) 17/99 (17%) | 8/70 (11%) 2/20 (10%) 7/41 (17%) 3/100 (3%) |
|ADJUSTED (b) | 37.2% 76.2% 80.5% 21.8% | 20.0% 22.2% 100.0% 3.9% |
|TERMINAL (d) | 14/45 (31%) 6/8 (75%) 20/25 (80%) 17/78 (22%) | 8/40 (20%) 1/5 (20%) 4/4 (100%) 3/77 (4%) |
|FIRST INCIDENCE (DAYS) | 491 574 649 734 (T) | 736 (T) 690 565 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.267 P=0.068 P=0.012N* | P=0.001N** P=0.433 P=0.002 ** P=0.006N** |
|INCIDENTAL TUMOR | P<0.001N** P=0.217 P=0.067 P=0.028N* | P=0.002N** P=0.369 P<0.001 ** P=0.006N** |
|LOGISTIC REGRESSION | P<0.001N** P=0.166 P=0.094 P=0.021N* | P=0.003N** P=0.416 P=0.092 P=0.006N** |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.016N* |
|FISHER EXACT | P=0.285 P=0.353 P=0.021N* | P=0.610N P=0.287 P=0.031N* |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 0/148 (0%) 0/100 (0%) | 2/100 (2%) 2/50 (4%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.2% 5.7% 1.7% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/39 (0%) 0/109 (0%) 0/78 (0%) | 0/70 (0%) 2/35 (6%) 1/113 (1%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 528 736 (T) 690 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.098N P=0.426 P=0.512N P=0.226N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.137N P=0.515 P=0.631N P=0.369N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.124N P=0.423 P=0.587N P=0.331N |
|COCHRAN-ARMITAGE | (e) | P=0.110N |
|FISHER EXACT | (e) (e) (e) | P=0.407 P=0.525N P=0.249N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/77 (1%) 1/36 (3%) 5/83 (6%) 3/99 (3%) |
|ADJUSTED (b) | | 2.1% 4.3% 9.3% 3.9% |
|TERMINAL (d) | | 1/48 (2%) 1/23 (4%) 4/47 (9%) 3/76 (4%) |
|FIRST INCIDENCE (DAYS) | | 736 (T) 736 (T) 735 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.598 P=0.589 P=0.120 P=0.480 |
|INCIDENTAL TUMOR | | P=0.599 P=0.589 P=0.121 P=0.480 |
|LOGISTIC REGRESSION | | P=0.577N P=0.589 P=0.111 P=0.480 |
|COCHRAN-ARMITAGE | | P=0.495 |
|FISHER EXACT | | P=0.538 P=0.123 P=0.410 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/56 (0%) 0/4 (0%) 0/31 (0%) 0/76 (0%) | 14/63 (22%) 3/17 (18%) 13/46 (28%) 6/85 (7%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 31.6% 100.0% 84.9% 9.1% |
|TERMINAL (d) | 0/35 (0%) 0/1 (0%) 0/2 (0%) 0/64 (0%) | 11/38 (29%) 3/3 (100%) 11/13 (85%) 6/66 (9%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 530 736 (T) 689 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P<0.001N** P=0.338 P=0.023 * P=0.002N** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P<0.001N** P=0.259 P=0.015 * P=0.003N** |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P<0.001N** P=0.419 P=0.070 P=0.003N** |
|COCHRAN-ARMITAGE | (e) | P=0.004N** |
|FISHER EXACT | (e) (e) (e) | P=0.486N P=0.308 P=0.008N** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/56 (0%) 1/4 (25%) 0/31 (0%) 0/76 (0%) | 15/63 (24%) 3/17 (18%) 13/46 (28%) 6/85 (7%) |
|ADJUSTED (b) | 0.0% 2.4% 0.0% 0.0% | 32.4% 100.0% 84.9% 9.1% |
|TERMINAL (d) | 0/35 (0%) 0/1 (0%) 0/2 (0%) 0/64 (0%) | 11/38 (29%) 3/3 (100%) 11/13 (85%) 6/66 (9%) |
|FIRST INCIDENCE (DAYS) | --- 669 --- --- | 530 736 (T) 689 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.545N P=0.362 (e) (e) | P<0.001N** P=0.449 P=0.053 P=0.001N** |
|INCIDENTAL TUMOR | P=0.725N P=0.056 (e) (e) | P<0.001N** P=0.329 P=0.036 * P=0.002N** |
|LOGISTIC REGRESSION | P=0.424N P=0.061 (e) (e) | P<0.001N** P=0.513 P=0.149 P=0.002N** |
|COCHRAN-ARMITAGE | P=0.425N | P=0.002N** |
|FISHER EXACT | P=0.067 (e) (e) | P=0.430N P=0.379 P=0.004N** |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 0/148 (0%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 2.6% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/76 (1%) 0/39 (0%) 0/109 (0%) 0/78 (0%) | 0/70 (0%) 0/35 (0%) 0/113 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 696 --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.202N P=0.394N P=0.163N P=0.232N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.217N P=0.475N P=0.160N P=0.281N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.209N P=0.404N P=0.160N P=0.248N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.204N | (e) |
|FISHER EXACT | P=0.443N P=0.162N P=0.249N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 3/148 (2%) 0/100 (0%) | 2/100 (2%) 1/50 (2%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 2.5% 0.0% 2.7% 0.0% | 2.4% 2.9% 1.5% 1.0% |
|TERMINAL (d) | 1/76 (1%) 0/39 (0%) 2/109 (2%) 0/78 (0%) | 0/70 (0%) 1/35 (3%) 0/113 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 673 --- 678 --- | 544 736 (T) 625 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.232N P=0.401N P=0.659 P=0.236N | P=0.373N P=0.730 P=0.509N P=0.474N |
|INCIDENTAL TUMOR | P=0.256N P=0.475N P=0.666 P=0.281N | P=0.535N P=0.704 P=0.628N P=0.746 |
|LOGISTIC REGRESSION | P=0.244N P=0.399N P=0.668 P=0.244N | P=0.514N P=0.729 P=0.591N P=0.701N |
|COCHRAN-ARMITAGE | P=0.236N | P=0.403N |
|FISHER EXACT | P=0.443N P=0.678 P=0.249N | P=0.742N P=0.525N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 0/148 (0%) 1/100 (1%) | 3/100 (3%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 1.2% | 3.5% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/76 (0%) 0/39 (0%) 0/109 (0%) 0/78 (0%) | 0/70 (0%) 0/35 (0%) 0/113 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 710 | 579 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.240 (e) (e) P=0.510 | P=0.095N P=0.275N P=0.056N P=0.111N |
|INCIDENTAL TUMOR | P=0.182 (e) (e) P=0.419 | P=0.118N P=0.212N P=0.080N P=0.133N |
|LOGISTIC REGRESSION | P=0.225 (e) (e) P=0.493 | P=0.125N P=0.279N P=0.079N P=0.166N |
|COCHRAN-ARMITAGE | P=0.230 | P=0.102N |
|FISHER EXACT | (e) (e) P=0.500 | P=0.293N P=0.063N P=0.123N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 0/50 (0%) 3/148 (2%) 1/100 (1%) | 3/100 (3%) 1/50 (2%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 5.0% 0.0% 2.7% 1.3% | 3.5% 2.9% 1.5% 1.0% |
|TERMINAL (d) | 2/76 (3%) 0/39 (0%) 2/109 (2%) 1/78 (1%) | 0/70 (0%) 1/35 (3%) 0/113 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 673 --- 678 734 (T) | 544 736 (T) 625 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.228N P=0.184N P=0.313N P=0.176N | P=0.245N P=0.575N P=0.294N P=0.286N |
|INCIDENTAL TUMOR | P=0.259N P=0.251N P=0.303N P=0.227N | P=0.387N P=0.547N P=0.423N P=0.513N |
|LOGISTIC REGRESSION | P=0.246N P=0.186N P=0.303N P=0.195N | P=0.370N P=0.581N P=0.379N P=0.494N |
|COCHRAN-ARMITAGE | P=0.234N | P=0.268N |
|FISHER EXACT | P=0.194N P=0.294N P=0.184N | P=0.593N P=0.316N P=0.311N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 3/148 (2%) 1/100 (1%) | 3/100 (3%) 1/50 (2%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 2.5% 0.0% 2.7% 1.3% | 3.5% 2.9% 1.5% 1.0% |
|TERMINAL (d) | 1/76 (1%) 0/39 (0%) 2/109 (2%) 1/78 (1%) | 0/70 (0%) 1/35 (3%) 0/113 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 673 --- 678 734 (T) | 544 736 (T) 625 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.493N P=0.401N P=0.659 P=0.493N | P=0.245N P=0.575N P=0.294N P=0.286N |
|INCIDENTAL TUMOR | P=0.531N P=0.475N P=0.666 P=0.540N | P=0.387N P=0.547N P=0.423N P=0.513N |
|LOGISTIC REGRESSION | P=0.518N P=0.399N P=0.668 P=0.514N | P=0.370N P=0.581N P=0.379N P=0.494N |
|COCHRAN-ARMITAGE | P=0.503N | P=0.268N |
|FISHER EXACT | P=0.443N P=0.678 P=0.500N | P=0.593N P=0.316N P=0.311N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 0/18 (0%) 3/62 (5%) 2/96 (2%) | 7/71 (10%) 0/27 (0%) 0/73 (0%) 0/98 (0%) |
|ADJUSTED (b) | 9.5% 0.0% 5.3% 2.6% | 11.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/47 (6%) 0/9 (0%) 1/27 (4%) 2/77 (3%) | 3/43 (7%) 0/13 (0%) 0/37 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 633 --- 633 734 (T) | 579 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.089N P=0.179N P=0.266N P=0.065N | P=0.004N** P=0.101N P=0.005N** P=0.003N** |
|INCIDENTAL TUMOR | P=0.119N P=0.202N P=0.246N P=0.102N | P=0.005N** P=0.090N P=0.006N** P=0.005N** |
|LOGISTIC REGRESSION | P=0.081N P=0.209N P=0.314N P=0.061N | P=0.004N** P=0.105N P=0.009N** P=0.003N** |
|COCHRAN-ARMITAGE | P=0.081N | P=0.004N** |
|FISHER EXACT | P=0.242N P=0.310N P=0.060N | P=0.096N P=0.006N** P=0.002N** |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 2/148 (1%) 0/100 (0%) | 5/100 (5%) 3/50 (6%) 3/150 (2%) 0/100 (0%) |
|ADJUSTED (b) | 2.6% 0.0% 1.8% 0.0% | 7.1% 8.0% 2.7% 0.0% |
|TERMINAL (d) | 2/76 (3%) 0/39 (0%) 2/109 (2%) 0/78 (0%) | 5/70 (7%) 2/35 (6%) 3/113 (3%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 734 (T) --- 734 (T) --- | 736 (T) 628 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.229N P=0.395N P=0.558N P=0.233N | P=0.013N* P=0.550 P=0.143N P=0.027N* |
|INCIDENTAL TUMOR | P=0.229N P=0.395N P=0.558N P=0.233N | P=0.014N* P=0.592 P=0.143N P=0.027N* |
|LOGISTIC REGRESSION | P=0.229N P=0.395N P=0.558N P=0.233N | P=0.013N* P=0.545 P=0.143N P=0.027N* |
|COCHRAN-ARMITAGE | P=0.232N | P=0.017N* |
|FISHER EXACT | P=0.443N P=0.531N P=0.249N | P=0.535 P=0.170N P=0.030N* |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/64 (0%) 0/12 (0%) 0/39 (0%) 2/100 (2%) | |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 2.6% | |
|TERMINAL (d) | 0/40 (0%) 0/1 (0%) 0/2 (0%) 2/78 (3%) | |
|FIRST INCIDENCE (DAYS) | --- --- --- 734 (T) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292 (e) (e) P=0.395 | |
|INCIDENTAL TUMOR | P=0.292 (e) (e) P=0.395 | |
|LOGISTIC REGRESSION | P=0.292 (e) (e) P=0.395 | |
|COCHRAN-ARMITAGE | P=0.171 | |
|FISHER EXACT | (e) (e) P=0.370 | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/63 (2%) 1/11 (9%) 1/39 (3%) 0/99 (0%) | 4/63 (6%) 0/15 (0%) 0/37 (0%) 8/99 (8%) |
|ADJUSTED (b) | 1.1% 2.2% 0.8% 0.0% | 11.1% 0.0% 0.0% 10.4% |
|TERMINAL (d) | 0/40 (0%) 0/1 (0%) 0/2 (0%) 0/78 (0%) | 4/36 (11%) 0/0 0/1 (0%) 7/76 (9%) |
|FIRST INCIDENCE (DAYS) | 646 584 639 --- | 736 (T) --- --- 730 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277N P=0.587 P=0.678N P=0.505N | P=0.543 (e) P=0.897N P=0.624 |
|INCIDENTAL TUMOR | P=0.357N P=0.545 P=0.659N P=0.564N | P=0.546 (e) P=0.897N P=0.622 |
|LOGISTIC REGRESSION | P=0.129N P=0.528 P=0.717 P=0.397N | P=0.586N (e) P=0.897N P=0.582N |
|COCHRAN-ARMITAGE | P=0.141N | P=0.189 |
|FISHER EXACT | P=0.277 P=0.621 P=0.389N | P=0.418N P=0.152N P=0.467 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/100 (2%) 0/50 (0%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | | 2.9% 0.0% 1.6% 0.0% |
|TERMINAL (d) | | 2/70 (3%) 0/35 (0%) 1/113 (1%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | | 736 (T) --- 465 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.217N P=0.401N P=0.519N P=0.218N |
|INCIDENTAL TUMOR | | P=0.275N P=0.401N P=0.601N P=0.218N |
|LOGISTIC REGRESSION | | P=0.258N P=0.401N P=0.570N P=0.218N |
|COCHRAN-ARMITAGE | | P=0.232N |
|FISHER EXACT | | P=0.443N P=0.525N P=0.249N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/100 (3%) 0/50 (0%) 3/150 (2%) 1/100 (1%) |
|ADJUSTED (b) | | 4.3% 0.0% 2.4% 1.3% |
|TERMINAL (d) | | 3/70 (4%) 0/35 (0%) 2/113 (2%) 1/77 (1%) |
|FIRST INCIDENCE (DAYS) | | 736 (T) --- 465 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.322N P=0.268N P=0.436N P=0.274N |
|INCIDENTAL TUMOR | | P=0.378N P=0.268N P=0.504N P=0.274N |
|LOGISTIC REGRESSION | | P=0.360N P=0.268N P=0.479N P=0.274N |
|COCHRAN-ARMITAGE | | P=0.351N |
|FISHER EXACT | | P=0.293N P=0.456N P=0.311N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 12/100 (12%) 1/50 (2%) 9/148 (6%) 4/100 (4%) | 10/100 (10%) 2/50 (4%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 14.8% 2.6% 7.6% 5.0% | 12.9% 5.2% 0.0% 0.0% |
|TERMINAL (d) | 9/76 (12%) 1/39 (3%) 5/109 (5%) 3/78 (4%) | 6/70 (9%) 1/35 (3%) 0/113 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 633 734 (T) 633 710 | 579 633 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.077N P=0.042N* P=0.095N P=0.033N* | P<0.001N** P=0.179N P<0.001N** P=0.001N** |
|INCIDENTAL TUMOR | P=0.109N P=0.042N* P=0.078N P=0.053N | P<0.001N** P=0.148N P<0.001N** P=0.002N** |
|LOGISTIC REGRESSION | P=0.088N P=0.042N* P=0.080N P=0.041N* | P<0.001N** P=0.169N P<0.001N** P=0.002N** |
|COCHRAN-ARMITAGE | P=0.078N | P<0.001N** |
|FISHER EXACT | P=0.033N* P=0.080N P=0.033N* | P=0.170N P<0.001N** P<0.001N** |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 12/100 (12%) 1/50 (2%) 9/148 (6%) 4/100 (4%) | 10/100 (10%) 2/50 (4%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 14.8% 2.6% 7.6% 5.0% | 12.9% 5.2% 0.7% 0.0% |
|TERMINAL (d) | 9/76 (12%) 1/39 (3%) 5/109 (5%) 3/78 (4%) | 6/70 (9%) 1/35 (3%) 0/113 (0%) 0/77 (0%) |
|FIRST INCIDENCE (DAYS) | 633 734 (T) 633 710 | 579 633 525 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.077N P=0.042N* P=0.095N P=0.033N* | P<0.001N** P=0.179N P<0.001N** P=0.001N** |
|INCIDENTAL TUMOR | P=0.109N P=0.042N* P=0.078N P=0.053N | P=0.001N** P=0.148N P=0.001N** P=0.002N** |
|LOGISTIC REGRESSION | P=0.088N P=0.042N* P=0.080N P=0.041N* | P=0.001N** P=0.169N P<0.001N** P=0.002N** |
|COCHRAN-ARMITAGE | P=0.078N | P<0.001N** |
|FISHER EXACT | P=0.033N* P=0.080N P=0.033N* | P=0.170N P<0.001N** P<0.001N** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 23/100 (23%) 6/50 (12%) 25/148 (17%) 14/100 (14%)| 34/100 (34%) 11/50 (22%) 42/150 (28%) 28/100 (28%)|
|ADJUSTED (b) | 26.1% 14.9% 20.6% 16.6% | 39.5% 27.8% 32.8% 32.1% |
|TERMINAL (d) | 13/76 (17%) 5/39 (13%) 16/109 (15%) 9/78 (12%) | 20/70 (29%) 7/35 (20%) 29/113 (26%) 19/77 (25%) |
|FIRST INCIDENCE (DAYS) | 576 669 412 408 | 128 544 185 568 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.138N P=0.095N P=0.193N P=0.079N | P=0.238N P=0.121N P=0.124N P=0.135N |
|INCIDENTAL TUMOR | P=0.260N P=0.133N P=0.150N P=0.194N | P=0.377N P=0.115N P=0.197N P=0.227N |
|LOGISTIC REGRESSION | P=0.147N P=0.202N P=0.139N P=0.079N | P=0.407N P=0.093N P=0.226N P=0.267N |
|COCHRAN-ARMITAGE | P=0.138N | P=0.371N |
|FISHER EXACT | P=0.080N P=0.151N P=0.072N | P=0.092N P=0.192N P=0.222N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 23/100 (23%) 6/50 (12%) 25/148 (17%) 14/100 (14%)| 34/100 (34%) 11/50 (22%) 42/150 (28%) 28/100 (28%)|
|ADJUSTED (b) | 26.1% 14.9% 20.6% 16.6% | 39.5% 27.8% 32.8% 32.1% |
|TERMINAL (d) | 13/76 (17%) 5/39 (13%) 16/109 (15%) 9/78 (12%) | 20/70 (29%) 7/35 (20%) 29/113 (26%) 19/77 (25%) |
|FIRST INCIDENCE (DAYS) | 576 669 412 408 | 128 544 185 568 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.138N P=0.095N P=0.193N P=0.079N | P=0.238N P=0.121N P=0.124N P=0.135N |
|INCIDENTAL TUMOR | P=0.260N P=0.133N P=0.150N P=0.194N | P=0.377N P=0.115N P=0.197N P=0.227N |
|LOGISTIC REGRESSION | P=0.147N P=0.202N P=0.139N P=0.079N | P=0.407N P=0.093N P=0.226N P=0.267N |
|COCHRAN-ARMITAGE | P=0.138N | P=0.371N |
|FISHER EXACT | P=0.080N P=0.151N P=0.072N | P=0.092N P=0.192N P=0.222N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 57/100 (57%) 20/50 (40%) 72/148 (49%) 62/100 (62%)| 45/100 (45%) 18/50 (36%) 75/150 (50%) 61/100 (61%)|
|ADJUSTED (b) | 62.3% 46.3% 58.1% 73.8% | 56.6% 45.8% 59.3% 66.9% |
|TERMINAL (d) | 42/76 (55%) 16/39 (41%) 58/109 (53%) 56/78 (72%) | 36/70 (51%) 14/35 (40%) 62/113 (55%) 47/77 (61%) |
|FIRST INCIDENCE (DAYS) | 491 574 535 612 | 530 587 525 503 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.100 P=0.050N P=0.201N P=0.354 | P=0.029 * P=0.203N P=0.469 P=0.101 |
|INCIDENTAL TUMOR | P=0.018 * P=0.048N* P=0.150N P=0.111 | P=0.010 ** P=0.239N P=0.383 P=0.037 * |
|LOGISTIC REGRESSION | P=0.023 * P=0.039N* P=0.142N P=0.145 | P=0.011 * P=0.198N P=0.412 P=0.043 * |
|COCHRAN-ARMITAGE | P=0.061 | P=0.003 ** |
|FISHER EXACT | P=0.037N* P=0.123N P=0.282 | P=0.190N P=0.259 P=0.017 * |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 60/100 (60%) 24/50 (48%) 95/148 (64%) 43/100 (43%)| 56/100 (56%) 22/50 (44%) 65/150 (43%) 48/100 (48%)|
|ADJUSTED (b) | 61.7% 50.8% 66.4% 47.7% | 58.0% 48.5% 47.7% 51.8% |
|TERMINAL (d) | 39/76 (51%) 16/39 (41%) 61/109 (56%) 31/78 (40%) | 30/70 (43%) 12/35 (34%) 43/113 (38%) 33/77 (43%) |
|FIRST INCIDENCE (DAYS) | 463 495 412 408 | 128 461 185 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.025N* P=0.156N P=0.267 P=0.024N* | P=0.173N P=0.184N P=0.024N* P=0.090N |
|INCIDENTAL TUMOR | P=0.105N P=0.149N P=0.273 P=0.100N | P=0.414N P=0.124N P=0.049N* P=0.246N |
|LOGISTIC REGRESSION | P=0.151N P=0.086N P=0.222 P=0.119N | P=0.470N P=0.082N P=0.061N P=0.309N |
|COCHRAN-ARMITAGE | P=0.010N* | P=0.316N |
|FISHER EXACT | P=0.111N P=0.296 P=0.012N* | P=0.112N P=0.033N* P=0.161N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- DIPHENYLHYDANTOIN
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | O PPM 30 PPM 100 PPM 300 PPM | 0 PPM 60 PPM 200 PPM 600 PPM |
| | 10-0 1-1 0-3 0-10 | 10-0 1-1 0-3 0-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 86/100 (86%) 33/50 (66%) 126/148 (85%) 81/100 (81%)| 76/100 (76%) 28/50 (56%) 111/150 (74%) 88/100 (88%)|
|ADJUSTED (b) | 86.8% 68.6% 86.9% 89.0% | 78.2% 62.0% 78.1% 88.0% |
|TERMINAL (d) | 63/76 (83%) 24/39 (62%) 90/109 (83%) 68/78 (87%) | 49/70 (70%) 18/35 (51%) 82/113 (73%) 65/77 (84%) |
|FIRST INCIDENCE (DAYS) | 463 495 412 408 | 128 461 185 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.443N P=0.030N* P=0.459 P=0.232N | P=0.094 P=0.052N P=0.197N P=0.349 |
|INCIDENTAL TUMOR | P=0.064 P=0.005N** P=0.572 P=0.341 | P<0.001 ** P=0.013N* P=0.456N P=0.012 * |
|LOGISTIC REGRESSION | P=0.049 * P=0.003N** P=0.513 P=0.571N | P<0.001 ** P=0.010N** P=0.449N P=0.010 * |
|COCHRAN-ARMITAGE | P=0.530N | P<0.001 ** |
|FISHER EXACT | P=0.005N** P=0.501N P=0.223N | P=0.011N* P=0.419N P=0.021 * |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).