TDMS Study 05075-01 Pathology Tables
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57-41-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|
| 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + M + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|
| 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + M + M +|
Adenoma | X |
Carcinoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Leukemia Mononuclear | X X |
Polyp Stromal | X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
Deep Cervical, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X X X X |
Mediastinal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|
| 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenoma | |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
Trichoepithelioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nares, Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + |
Lids, Fibrosarcoma | X |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3| |
| 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 13 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 2 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Benign | X X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3| |
| 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + M + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | X X X X X X X X X X X | 25 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | X X X X X X X| 12 |
C-Cell, Carcinoma | X X | 2 |
Follicular Cell, Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M + + + M + + + + + + +| 45 |
Adenoma | X X X | 4 |
Carcinoma | X | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | | 2 |
Polyp Stromal | X X X X | 6 |
__________________________________________________________________________|____________|
Vagina | + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Axillary, Leukemia Mononuclear | | 1 |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | X | 1 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 1 |
Mandibular, Leukemia Mononuclear | X X X X X | 9 |
Mediastinal, Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3| |
| 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 13 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + M + + + + + + + + + + +| 46 |
Leukemia Mononuclear | X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 3 |
Adenoma | X | 1 |
Fibroadenoma | X X X X X X X X X | 16 |
Fibroadenoma, Multiple | X| 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X | 1 |
Leukemia Mononuclear | | 1 |
Squamous Cell Carcinoma | X | 1 |
Trichoepithelioma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Leukemia Mononuclear | X X X X X X | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nares, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3| |
| 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + +| 9 |
Lids, Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|
| 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
Carcinoma, Metastatic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|
| 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + |
Polyp Stromal | X X X |
Polyp Stromal, Multiple | |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Deep Cervical, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X X X |
Mediastinal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + I + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + |
Adenocarcinoma | X X |
Adenoma | X |
Fibroadenoma | X X X X X X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|
| 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1| |
| 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A +| 20 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Leukemia Mononuclear | X X X X X X| 14 |
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 6 |
Leukemia Mononuclear | X X| 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A +| 20 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + +| 21 |
Carcinoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A +| 20 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + +| 21 |
Leukemia Mononuclear | X X X| 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + A +| 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + A +| 21 |
Leukemia Mononuclear | X X X| 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + A +| 21 |
Leukemia Mononuclear | X X X| 4 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A +| 20 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M +| 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1| |
| 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X| 3 |
Pars Distalis, Adenoma | X X X X X X X X X | 26 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A +| 20 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X X| 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + I + + +| 21 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + +| 23 |
Leukemia Mononuclear | X X| 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + +| 26 |
Polyp Stromal | X | 4 |
Polyp Stromal, Multiple | X | 1 |
Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + A +| 21 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | X| 1 |
Mandibular, Leukemia Mononuclear | X X X X| 7 |
Mediastinal, Leukemia Mononuclear | X X X X| 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + +| 26 |
Leukemia Mononuclear | X X X X X X X| 15 |
__________________________________________________________________________|____________|
Thymus | + + + M + + I + +| 18 |
Leukemia Mononuclear | X X X| 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + A +| 24 |
Adenocarcinoma | X | 3 |
Adenoma | | 1 |
Fibroadenoma | X | 9 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1| |
| 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + +| 22 |
Leukemia Mononuclear | X | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + +| 21 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + +| 21 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + +| 22 |
Leukemia Mononuclear | X X X X X| 9 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + +| 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + +| 21 |
Leukemia Mononuclear | X X X| 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A +| 21 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|
| 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|
| 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + +|
Adenoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Leiomyosarcoma | X |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + I|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X X X|
Mediastinal, Leukemia Mononuclear | X X|
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + +|
Hemangioma | |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Fibroadenoma | X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|
| 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3| |
| 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + A | 20 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + A | 20 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A | 20 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 20 |
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 23 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 24 |
Leukemia Mononuclear | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 23 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 23 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 23 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + M + + | 21 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + | 43 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X X X X X X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3| |
| 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + A A | 19 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + | 24 |
Adenoma | X | 4 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 26 |
Leiomyosarcoma | | 1 |
Polyp Stromal | X X X X X | 6 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 26 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Mandibular, Leukemia Mononuclear | X X X X X X X X | 11 |
Mediastinal, Leukemia Mononuclear | X X X X | 6 |
Pancreatic, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 4 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 29 |
Hemangioma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + | 21 |
Leukemia Mononuclear | X X X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 31 |
Fibroadenoma | X X X X X X | 14 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 23 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3| |
| 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 23 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 24 |
Leukemia Mononuclear | X X X X X X X | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 23 |
Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + A A + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + A + + + +|
__________________________________________________________________________|
Salivary Glands | + + A + + + +|
__________________________________________________________________________|
Stomach | + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + A + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + A + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + A A + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + +|
Adenoma | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Polyp Stromal | X X X X X |
Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + + + +|
__________________________________________________________________________|
Lymph Node | + + A + + + +|
Inguinal, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + A + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + +|
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Sarcoma | |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | +|
Carcinoma | X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + A + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| |
| 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large | + + A + A + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + A + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + A + | 10 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + A + A + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + A + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + A + | 9 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + A + A + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + A + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + A + | 11 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 13 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 13 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 13 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + | 11 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + +| 32 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X X X X | 19 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + A + A + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| |
| 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + | 14 |
Adenoma | X X | 2 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 25 |
Polyp Stromal | X X X X X X | 11 |
Sarcoma Stromal | X | 1 |
__________________________________________________________________________|____________|
Vagina | + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 12 |
Inguinal, Leukemia Mononuclear | X | 1 |
Mandibular, Leukemia Mononuclear | X | 2 |
Mediastinal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + A + + + + + | 17 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 12 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 19 |
Adenocarcinoma | X | 2 |
Fibroadenoma | X X X X | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 14 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 13 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| |
| 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 13 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + | 13 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + | 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|
| 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + A + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + A + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + A + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Small | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + + + +|
Leukemia Mononuclear | |
Submucosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma, Multiple | X |
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + A + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + +|
Leukemia Mononuclear | X|
Endocardium, Schwannoma Benign | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + A + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + A + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + A + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|
| 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | A + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | A + + + + + A + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X|
Follicular Cell, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Leiomyoma | X |
Leukemia Mononuclear | |
Polyp Stromal | X X X X X X|
Sarcoma Stromal | X |
Cervix, Carcinoma Adenosquamous | X |
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X X X|
Mediastinal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Spleen | + + + + + + A + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Thymus | + + + M + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|
| 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Keratoacanthoma | X |
Leukemia Mononuclear | |
Squamous Cell Papilloma | X X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Sarcoma | |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Urinary Bladder | A + + + + + A + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3| |
| 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
Submucosa, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma, Multiple | | 1 |
Leukemia Mononuclear | X X X X X X | 10 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 21 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X X | 3 |
Endocardium, Schwannoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3| |
| 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X X | 3 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + +| 35 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X X| 15 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X | 3 |
Follicular Cell, Adenocarcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + | 24 |
Adenoma | X X X X | 4 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 35 |
Adenocarcinoma | | 1 |
Leiomyoma | | 1 |
Leukemia Mononuclear | X | 1 |
Polyp Stromal | X X X X X X X | 13 |
Sarcoma Stromal | | 1 |
Cervix, Carcinoma Adenosquamous | | 1 |
__________________________________________________________________________|____________|
Vagina | + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 23 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Mandibular, Leukemia Mononuclear | X X X X X | 8 |
Mediastinal, Leukemia Mononuclear | X X X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 6 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3| |
| 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X X X X X X | 9 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 19 |
Leukemia Mononuclear | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + | 25 |
Adenoma | | 1 |
Fibroadenoma | X X X X | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 26 |
Keratoacanthoma | | 1 |
Leukemia Mononuclear | X | 1 |
Squamous Cell Papilloma | | 2 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 23 |
Leukemia Mononuclear | X X X X X | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 22 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3| |
| 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|
| 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + |
Adenocarcinoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tongue | +|
Squamous Cell Carcinoma | X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Pericardium, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Carcinoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|
| 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + |
Leukemia Mononuclear | X |
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + |
Adenocarcinoma | |
Leukemia Mononuclear | |
Polyp Stromal | X X X X X X |
Sarcoma Stromal | X |
Wall, Leukemia Mononuclear | X |
__________________________________________________________________________|
Vagina | + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X X X X X |
Mediastinal, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|
| 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + |
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Adrenal Gland | X |
Leukemia Mononuclear | X X X X X X |
Sarcoma, Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + |
Leukemia Mononuclear | X X |
Wall, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| |
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3| |
| 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 16 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 16 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 16 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 16 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A | 15 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 17 |
Adenocarcinoma | X | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X| 14 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 16 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 16 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 16 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 17 |
Leukemia Mononuclear | X | 6 |
Pericardium, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| |
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3| |
| 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 17 |
Carcinoma | | 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 17 |
Leukemia Mononuclear | X | 4 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 33 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X X X X X | 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + +| 17 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X X| 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 20 |
Carcinoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 21 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + +| 31 |
Adenocarcinoma | X | 1 |
Leukemia Mononuclear | X| 1 |
Polyp Stromal | X X X X X | 11 |
Sarcoma Stromal | | 1 |
Wall, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Vagina | + +| 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 22 |
Deep Cervical, Leukemia Mononuclear | X| 2 |
Inguinal, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mandibular, Leukemia Mononuclear | X X X| 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| |
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3| |
| 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Leukemia Mononuclear | X X X| 6 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | +| 6 |
Leukemia Mononuclear | X| 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + +| 21 |
Leukemia Mononuclear | X X X X X X| 13 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M| 17 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 23 |
Fibroadenoma | X X X X | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 18 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + +| 18 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Adrenal Gland | | 1 |
Leukemia Mononuclear | X X X| 9 |
Sarcoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + +| 9 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 17 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 16 |
Leukemia Mononuclear | | 2 |
Wall, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| |
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3| |
| 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X| 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + M|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Endocardium, Schwannoma Benign | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X X X X X |
Endometrium, Adenoma | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X X X X X X X |
Mediastinal, Leukemia Mononuclear | X X X X X X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | M + M M + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Ventral, Leukemia | |
Mononuclear | X |
Head, Leukemia Mononuclear | X |
Neck, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Nerve, Leukemia Mononuclear | X |
Sinus, Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3| |
| 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X | 12 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 5 |
Endocardium, Schwannoma Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3| |
| 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 4 |
Pheochromocytoma Benign | X X| 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + M + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | X X X X | 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Carcinoma | X | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa Cell Tumor Malignant | | 1 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
Polyp Stromal | X X X X X X | 12 |
Endometrium, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Vagina | + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Inguinal, Leukemia Mononuclear | X | 1 |
Mandibular, Leukemia Mononuclear | X X X X X X | 13 |
Mediastinal, Leukemia Mononuclear | X X X X X | 11 |
Pancreatic, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3| |
| 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 12 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
Leukemia Mononuclear | X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroadenoma | X X | 4 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Ventral, Leukemia | | |
Mononuclear | | 1 |
Head, Leukemia Mononuclear | | 1 |
Neck, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | X X X X X X | 13 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nerve, Leukemia Mononuclear | | 1 |
Sinus, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3| |
| 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 7 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|
| 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X |
Follicular Cell, Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|
| 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X |
Sarcoma Stromal | X |
Endometrium, Adenocarcinoma | |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
Spinal, Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|
| 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + +|
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8| |
| 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
Pheochromocytoma Benign | X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Adenoma | X X X X X X X| 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, C-Cell, Adenoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8| |
| 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Adenoma | X | 4 |
Follicular Cell, Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X X | 6 |
Sarcoma Stromal | | 1 |
Endometrium, Adenocarcinoma | X | 1 |
Endometrium, Sarcoma Stromal | X | 1 |
__________________________________________________________________________|____________|
Vagina | + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Leukemia Mononuclear | X X X X X | 7 |
Mediastinal, Leukemia Mononuclear | X X X | 5 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 3 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibroadenoma | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8| |
| 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | +| 1 |
Spinal, Schwannoma Malignant | X| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + +| 4 |
__________________________________________________________________________|____________|
Eye | + + | 4 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|
| 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + A|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Schwannoma Benign | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Capsule, Mesothelioma | |
Malignant | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|
| 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Pheochromocytoma Benign | X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Nervosa, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
Bilateral, C-Cell, Adenoma | X X X |
C-Cell, Adenoma | X X X X X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Bilateral, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X|
Bilateral, Tunic, Mesothelioma | |
Malignant | |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|
| 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Histiocytic Sarcoma | X |
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mandibular, Histiocytic Sarcoma | X |
Mandibular, Leukemia Mononuclear | X X X X X X X X X|
Mediastinal, Leukemia Mononuclear | X X X X X X X X |
Pancreatic, Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + M + M M M + + +|
Leukemia Mononuclear | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + |
Adenocarcinoma | |
Fibroadenoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Leukemia Mononuclear | |
Squamous Cell Carcinoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Benign | X |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|
| 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp | |
Nares, Leukemia Mononuclear | |
Nasolacrimal Duct, Histiocytic | |
Sarcoma | X |
Sinus, Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
Sarcoma | X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + +| 46 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 25 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 7 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 14 |
Schwannoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Capsule, Mesothelioma | | |
Malignant | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 16 |
Pheochromocytoma Benign | X X X X X| 13 |
Bilateral, Pheochromocytoma Benign | X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 3 |
Pars Distalis, Adenoma | X X X X X X | 14 |
Pars Nervosa, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
Bilateral, C-Cell, Adenoma | | 3 |
C-Cell, Adenoma | X X | 8 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Adenocarcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mesothelioma Malignant | X | 1 |
Bilateral, Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 2 |
Carcinoma | X | 2 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X| 42 |
Bilateral, Tunic, Mesothelioma | | |
Malignant | X X | 2 |
Interstitial Cell, Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Histiocytic Sarcoma | | 1 |
Femoral, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deep Cervical, Leukemia Mononuclear | X X | 2 |
Inguinal, Leukemia Mononuclear | X | 1 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mandibular, Histiocytic Sarcoma | | 1 |
Mandibular, Leukemia Mononuclear | X X X X X X X X X X X X | 21 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X X X X | 19 |
Pancreatic, Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 5 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 25 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + M + + + + + + M + M + + + + + + + M| 40 |
Leukemia Mononuclear | X X X X X X X X X | 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + +| 23 |
Adenocarcinoma | X | 1 |
Fibroadenoma | X | 3 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Keratoacanthoma | X | 1 |
Leukemia Mononuclear | X | 1 |
Squamous Cell Carcinoma | X | 2 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Benign | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Carcinoma | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 23 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp | X| 1 |
Nares, Leukemia Mononuclear | X | 1 |
Nasolacrimal Duct, Histiocytic | | |
Sarcoma | | 1 |
Sinus, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + | 9 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 21 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 25 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|
| 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + A + + + + +|
Lymphoid Nodule, Leukemia Mononuclear| |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + A + + + A + + + + +|
Lymphoid Nodule, Leukemia Mononuclear| |
__________________________________________________________________________|
Intestine Small | + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + A + + + A + + + + +|
Leukemia Mononuclear | X |
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + + A + + + + +|
Leukemia Mononuclear | X |
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|
| 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + A + A + + + A + + + + + +|
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenocarcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X|
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + +|
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X X X X X X|
Mediastinal, Leukemia Mononuclear | X X X X|
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|
| 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Capsule, Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Keratoacanthoma | |
Leukemia Mononuclear | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|
| 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6| |
| 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + A + + +| 22 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + +| 24 |
Lymphoid Nodule, Leukemia Mononuclear| X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + +| 24 |
Lymphoid Nodule, Leukemia Mononuclear| X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + A + + +| 22 |
Leukemia Mononuclear | | 1 |
Peyer's Patch, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + +| 24 |
Leukemia Mononuclear | | 1 |
Peyer's Patch, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 23 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + +| 27 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + +| 26 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + +| 25 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + +| 28 |
Leukemia Mononuclear | X X X X X X X X | 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6| |
| 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X | 8 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X X X X| 11 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + +| 27 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +| 34 |
Pars Distalis, Adenoma | X X X X X X X X X | 10 |
Pars Distalis, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + +| 26 |
C-Cell, Adenoma | X X X X X X| 11 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenocarcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + +| 27 |
Adenoma | | 1 |
Carcinoma | X | 1 |
Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X| 45 |
Interstitial Cell, Adenoma | X X X | 5 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + +| 26 |
Femoral, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 27 |
Inguinal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6| |
| 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Leukemia Mononuclear | | 1 |
Mandibular, Leukemia Mononuclear | X X X X X X X X X X X | 17 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X X | 13 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 7 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 24 |
Capsule, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + M + + +| 23 |
Leukemia Mononuclear | X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 12 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + +| 29 |
Keratoacanthoma | X| 1 |
Leukemia Mononuclear | X | 1 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Fibroma | X| 1 |
Subcutaneous Tissue, Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + +| 27 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X X X X X | 5 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
Schwannoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + +| 27 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6| |
| 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + +| 28 |
Leukemia Mononuclear | X X X X X X X X X X | 16 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + +| 26 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 25 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|
DAY ON TEST | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|
| 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + A + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + + A A|
__________________________________________________________________________|
Intestine Large, Colon | A + M + + A + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + A + + + A +|
Lymphoid Nodule, Leukemia Mononuclear| X |
__________________________________________________________________________|
Intestine Small | A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + + + A A|
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + A A|
__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + A +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | A + + + + + + + + + +|
__________________________________________________________________________|
Stomach | A + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + A +|
Serosa, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|
DAY ON TEST | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|
| 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + A + + + + A + + + A A|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Chemodectoma Benign | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + +|
Bilateral, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X |
Bilateral, Tunic, Mesothelioma | |
Malignant | X |
Interstitial Cell, Adenoma | X X X X |
Interstitial Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A +|
Femoral, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Inguinal, Leukemia Mononuclear | X X |
Mandibular, Histiocytic Sarcoma | |
Mandibular, Leukemia Mononuclear | X X X X X X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|
DAY ON TEST | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|
| 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + +|
Leukemia Mononuclear | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + A +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5| |
| 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + +| 14 |
Lymphoid Nodule, Leukemia Mononuclear| | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + +| 13 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + +| 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 1 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X| 22 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + +| 16 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach | + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + +| 15 |
Serosa, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + +| 18 |
Leukemia Mononuclear | X X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5| |
| 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X X X | 11 |
Bilateral, Pheochromocytoma Benign | X X X X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + +| 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + +| 20 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + +| 14 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X X| 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Chemodectoma Benign | X | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + +| 17 |
Bilateral, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + +| 18 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + + +| 17 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X X| 42 |
Bilateral, Tunic, Mesothelioma | | |
Malignant | | 1 |
Interstitial Cell, Adenoma | X | 5 |
Interstitial Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + +| 16 |
Femoral, Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 19 |
Inguinal, Leukemia Mononuclear | | 2 |
Mandibular, Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5| |
| 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Leukemia Mononuclear | X X X | 9 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Mediastinal, Leukemia Mononuclear | X X | 5 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 4 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 29 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X | 19 |
__________________________________________________________________________|____________|
Thymus | + + M + + M| 15 |
Leukemia Mononuclear | X X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 8 |
Fibroadenoma | X X X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + +| 20 |
Leukemia Mononuclear | X | 1 |
Subcutaneous Tissue, Fibroma | X X X| 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + +| 18 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + +| 17 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + +| 18 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma, Metastatic | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Nose | + + + + + +| 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + +| 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5| |
| 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 21 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + +| 15 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X| 22 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|
| 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + M + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X |
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A +|
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Leukemia Mononuclear | X |
Capsule, Mesothelioma Malignant | X X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|
| 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X |
Pars Intermedia, Adenoma | X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abdominal, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + +|
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X|
Bilateral, Tunic, Mesothelioma | |
Malignant | X X |
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A +|
Femoral, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X X X X X |
Mediastinal, Leukemia Mononuclear | X X X |
Mediastinal, Mesothelioma Malignant | X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|
| 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Keratoacanthoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Capsule, Mesothelioma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A +|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4| |
| 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + | 22 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 23 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 23 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X | 22 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 23 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 24 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 25 |
Leukemia Mononuclear | X X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Leukemia Mononuclear | | 1 |
Capsule, Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4| |
| 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X X X X X X X X X | 19 |
Bilateral, Pheochromocytoma Benign | X X X X X| 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + +| 31 |
Leukemia Mononuclear | X X | 3 |
Pars Distalis, Adenoma | X X X X X| 8 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + + + + + + | 22 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Abdominal, Mesothelioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + | 24 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 24 |
Adenoma | X X | 2 |
Leukemia Mononuclear | X X X | 7 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + | 24 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X | 43 |
Bilateral, Tunic, Mesothelioma | | |
Malignant | | 2 |
Interstitial Cell, Adenoma | X X X | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 23 |
Femoral, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4| |
| 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Deep Cervical, Leukemia Mononuclear | | 1 |
Mandibular, Leukemia Mononuclear | X X X X X X X | 12 |
Mediastinal, Leukemia Mononuclear | X X X X | 7 |
Mediastinal, Mesothelioma Malignant | | 1 |
Pancreatic, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 31 |
Leukemia Mononuclear | X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + | 23 |
Leukemia Mononuclear | X X X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 31 |
Basal Cell Adenoma | X | 2 |
Keratoacanthoma | X X | 3 |
Squamous Cell Papilloma | X X | 2 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 25 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 24 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 24 |
Leukemia Mononuclear | X X X X X X | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 25 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + +| 4 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4| |
| 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 28 |
Leukemia Mononuclear | X X X X X | 13 |
Capsule, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 23 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 24 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|
| 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + A + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + A + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + A + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + A + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + A + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + A + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + A + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + A + +|
__________________________________________________________________________|
Stomach | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + A + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + A + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|
| 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + A + + +|
Capsule, Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + A + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + A + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + A + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X|
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + A + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + M + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X|
Bilateral, Tunic, Mesothelioma | |
Malignant | X |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + +|
Femoral, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + A + +|
Inguinal, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|
| 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Histiocytic Sarcoma | |
Mandibular, Leukemia Mononuclear | X X X X X X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X X X X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Leukemia Mononuclear | X X X |
Mediastinal, Mesothelioma Malignant, | |
Metastatic, Mesentery | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X |
Capsule, Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X X X |
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + +|
Fibroadenoma | |
Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Leukemia Mononuclear | X |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Osteosarcoma | |
Vertebra, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|
| 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X |
Osteosarcoma, Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Transitional Epithelium, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + A + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + | 26 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + | 26 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + | 26 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + | 26 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + | 26 |
Leukemia Mononuclear | X X | 3 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + | 26 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocellular Adenoma | X | 1 |
Hepatocellular Adenoma, Multiple | X| 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X| 20 |
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Leukemia Mononuclear | X X X | 4 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 28 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 27 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 27 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 27 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + | 26 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Tongue | | 2 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 29 |
Leukemia Mononuclear | X X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Capsule, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X | 9 |
Pheochromocytoma Malignant | X | 2 |
Pheochromocytoma Benign | X X | 4 |
Bilateral, Pheochromocytoma Benign | X X X| 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 28 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + | 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 30 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X | 10 |
Pars Distalis, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + + + + + A | 27 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X X X X | 5 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 27 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 33 |
Adenoma | | 1 |
Carcinoma | X | 1 |
Leukemia Mononuclear | X X X X X | 9 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 28 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X| 42 |
Bilateral, Tunic, Mesothelioma | | |
Malignant | | 1 |
Interstitial Cell, Adenoma | X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 28 |
Femoral, Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 29 |
Inguinal, Leukemia Mononuclear | X | 2 |
Mandibular, Histiocytic Sarcoma | X | 1 |
Mandibular, Leukemia Mononuclear | X X X X X X X X | 14 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X | 13 |
Pancreatic, Leukemia Mononuclear | X | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 8 |
Leukemia Mononuclear | X X | 5 |
Mediastinal, Mesothelioma Malignant, | | |
Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 35 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 19 |
Capsule, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 28 |
Leukemia Mononuclear | X X X X X | 9 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 14 |
Fibroadenoma | X | 1 |
Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 29 |
Keratoacanthoma | | 1 |
Leukemia Mononuclear | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 29 |
Osteosarcoma | X | 1 |
Vertebra, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 29 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
Schwannoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 30 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X | 15 |
Osteosarcoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 29 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 31 |
Leukemia Mononuclear | X X X X X X | 12 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 27 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X| 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|
| 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + + + A + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + A + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + A + + + + + + + +|
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|
| 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + A A + + + + A + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X|
Bilateral, Tunic, Mesothelioma | |
Malignant | X |
Interstitial Cell, Adenoma | X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + A + + + + + + + + + + + + +|
Mandibular, Leukemia Mononuclear | X X X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X X |
Sarcoma | |
Capsule, Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|
| 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Fibroadenoma | |
Sarcoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Pinna, Basosquamous Tumor Benign | X |
Pinna, Fibrosarcoma | X |
__________________________________________________________________________|
Eye | + + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Transitional Epithelium, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + M A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4| |
| 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 27 |
__________________________________________________________________________|____________|
Intestine Large | A + A + + A A + A + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + A A + A + + + + | 21 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + A + + A A + A + + + + | 23 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + A + + A A + A + + + + | 22 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + A A + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A A + + + + + + | 25 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + A A + A + + + + | 23 |
Peyer's Patch, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + A A + A + + + + | 22 |
__________________________________________________________________________|____________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | X X X X | 9 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | A + + + + A A + + + + + + | 25 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 28 |
__________________________________________________________________________|____________|
Stomach | A + + + + + A + + + + + + | 26 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + A + + + + + + | 26 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + A + + A A + A + + + + | 23 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 29 |
Leukemia Mononuclear | X X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 4 |
Pheochromocytoma Malignant | X X | 4 |
Pheochromocytoma Benign | X X X X | 16 |
Bilateral, Pheochromocytoma Benign | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4| |
| 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + A A + + + + + + | 25 |
Adenoma | | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + M + +| 27 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X| 5 |
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + A + + + + + + | 23 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | X X X | 5 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + | 30 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 29 |
Carcinoma | | 1 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + | 29 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X| 41 |
Bilateral, Tunic, Mesothelioma | | |
Malignant | X | 2 |
Interstitial Cell, Adenoma | X X X X | 5 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 29 |
Mandibular, Leukemia Mononuclear | X X | 5 |
Mediastinal, Leukemia Mononuclear | X X | 5 |
Pancreatic, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 98
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4| |
| 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + | 29 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X X X | 8 |
Sarcoma | X | 1 |
Capsule, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M + + | 25 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 7 |
Fibroadenoma | X | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 30 |
Keratoacanthoma | X | 1 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 27 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 29 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 29 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Leukemia Mononuclear | X X X | 7 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
Pinna, Basosquamous Tumor Benign | | 1 |
Pinna, Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 99
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4| |
| 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
Carcinoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + + + | 30 |
Leukemia Mononuclear | X X X | 6 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + A A + + + + + + | 24 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 9 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 100
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|
| 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tooth | + |
Molar, Adamantinoma Benign | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
Leukemia Mononuclear | X X |
Ventricle Left, Schwannoma Benign | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Capsule, Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|
| 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X X X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenocarcinoma | |
Follicular Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | X |
Deep Cervical, Mediastinal, | |
Mandibular, Carcinoma, | |
Metastatic, Thyroid Gland | X |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|
| 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Leukemia Mononuclear | X |
Mandibular, Carcinoma, Metastatic, | |
Skin | |
Mandibular, Leukemia Mononuclear | X X X X |
Mediastinal, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + M M + M + M M + + + + + + + + M + + + M M M + M|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + +|
Fibroma | |
Keratoacanthoma | |
Leukemia Mononuclear | X X |
Squamous Cell Carcinoma | X |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Left, Femur, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Carcinoma, | |
Metastatic, Thyroid Gland | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|
| 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + A + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + A| 47 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + A + + M + A| 46 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + A + + + + A| 47 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + A| 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + A| 47 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + A| 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | X X | 3 |
Hepatocellular Adenoma, Multiple | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 19 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + M + + + + + A| 48 |
Leukemia Mononuclear | X X X | 5 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Molar, Adamantinoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X| 13 |
Ventricle Left, Schwannoma Benign | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 105
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X | 8 |
Pheochromocytoma Benign | X X X X X | 16 |
Bilateral, Pheochromocytoma Benign | X X X X X X | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Pars Distalis, Adenoma | X X X X X | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + A| 48 |
Leukemia Mononuclear | | 2 |
C-Cell, Adenoma | X X X X X | 10 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenocarcinoma | X | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
Bilateral, Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X| 9 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X| 40 |
Interstitial Cell, Adenoma | X X X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 106
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Tunic, Mesothelioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Femoral, Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Deep Cervical, Mediastinal, | | |
Mandibular, Carcinoma, | | |
Metastatic, Thyroid Gland | | 1 |
Inguinal, Leukemia Mononuclear | | 1 |
Mandibular, Carcinoma, Metastatic, | | |
Skin | X | 1 |
Mandibular, Leukemia Mononuclear | X X X X X X X X X X X X X X| 18 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X X X| 14 |
Pancreatic, Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 8 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 19 |
__________________________________________________________________________|____________|
Thymus | + M M + M M + + + + M + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X X X X X X X X X X X X| 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibroma | X | 1 |
Keratoacanthoma | X | 1 |
Leukemia Mononuclear | | 2 |
Squamous Cell Carcinoma | X | 2 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Left, Femur, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 107
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X| 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 19 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lamina Propria, Carcinoma, | | |
Metastatic, Thyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | +| 1 |
Carcinoma | X| 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 17 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 19 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 108
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 0| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 1|
| 7| 5| 2| 2| 2| 2| 3| 3| 3| 3| 7| 3| 3| 9| 9| 4| 4| 4| 4| 5| 5| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + M + + + + A + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X X X X |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 0| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 1|
| 7| 5| 2| 2| 2| 2| 3| 3| 3| 3| 7| 3| 3| 9| 9| 4| 4| 4| 4| 5| 5| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X|
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, C-Cell, Adenoma | X X |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + M + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X|
Bilateral, Tunic, Mesothelioma | |
Malignant | |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Histiocytic Sarcoma | X |
Sternal, Histiocytic Sarcoma | X |
Vertebral, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Leukemia Mononuclear | |
Deep Cervical, Mediastinal, | |
Mandibular, Carcinoma, | |
Metastatic, Thyroid Gland | |
Inguinal, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 0| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 1|
| 7| 5| 2| 2| 2| 2| 3| 3| 3| 3| 7| 3| 3| 9| 9| 4| 4| 4| 4| 5| 5| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X X X X X X X X|
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Leukemia Mononuclear | X X X X X X|
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X|
Sarcoma | X |
Capsule, Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | + + M + + + + M M M + M + + + + + + + + M M + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + |
Abdominal, Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Keratoacanthoma | X |
Schwannoma Malignant | X |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Oligodendroglioma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nares, Leukemia Mononuclear | |
Sinus, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 0| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 1|
| 7| 5| 2| 2| 2| 2| 3| 3| 3| 3| 7| 3| 3| 9| 9| 4| 4| 4| 4| 5| 5| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Leukemia Mononuclear | |
Peritracheal Tissue, Leukemia | |
Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Leukemia Mononuclear | |
__________________________________________________________________________|
Eye | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X | 3 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Hepatocellular Adenoma | | 1 |
Hepatocellular Adenoma, Multiple | | 4 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 20 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 4 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Leiomyosarcoma | X | 1 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 113
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 10 |
Pheochromocytoma Malignant | X | 3 |
Pheochromocytoma Benign | X X X X X X| 16 |
Bilateral, Pheochromocytoma Benign | X X X X X | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + + M M + + + + + + + M + M + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X X X | 9 |
Pars Distalis, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
Bilateral, C-Cell, Adenoma | X X | 4 |
C-Cell, Adenoma | X X X X X X X | 10 |
C-Cell, Carcinoma | X X X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 2 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X| 35 |
Bilateral, Tunic, Mesothelioma | | |
Malignant | X X | 2 |
Interstitial Cell, Adenoma | X X X X X X X | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 114
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Histiocytic Sarcoma | | 1 |
Sternal, Histiocytic Sarcoma | | 1 |
Vertebral, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deep Cervical, Leukemia Mononuclear | X X | 2 |
Deep Cervical, Mediastinal, | | |
Mandibular, Carcinoma, | | |
Metastatic, Thyroid Gland | X | 1 |
Inguinal, Leukemia Mononuclear | X X X | 4 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mandibular, Leukemia Mononuclear | X X X X X X X X X X X X | 20 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X X | 15 |
Pancreatic, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 8 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 20 |
Sarcoma | | 1 |
Capsule, Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + M + M + + + + + + + M +| 39 |
Leukemia Mononuclear | X X X X X X X | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 18 |
Abdominal, Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Adenoma | | 1 |
Keratoacanthoma | | 1 |
Schwannoma Malignant | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 115
NTP Experiment-Test: 05075-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/10/97
Route: DOSED FEED Time: 06:58:25
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 5 |
Oligodendroglioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma | X X | 3 |
Carcinoma, Metastatic, Thyroid Gland | X X | 2 |
Leukemia Mononuclear | X X X X X X X X X X | 18 |
Pheochromocytoma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nares, Leukemia Mononuclear | X | 1 |
Sinus, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lamina Propria, Leukemia Mononuclear | X | 1 |
Peritracheal Tissue, Leukemia | | |
Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 3 |
Middle Ear, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Eye | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X | 17 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 20 |
Mesothelioma Malignant | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 116
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---------- END OF REPORT ----------
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