Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2135

TDMS Study 05075-01 Pathology Tables

NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97
Route: DOSED FEED                                                                                                 Time: 06:58:25




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57-41-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X           X     X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X  X                       X           X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                              +         |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X           X     X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X           X     X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                                      X                           |             
      Leukemia Mononuclear                 |                            X                       X           X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                       X           X         |             
      Pheochromocytoma Benign              |                                           X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X           X  X     X  X  X  X  X     X        X     X  X  X     X   |             
      Pars Distalis, Carcinoma             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                             X            |             
      C-Cell, Adenoma                      |             X                 X  X  X        X                           |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenocarcinoma      |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |                                                             X            |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                 X                        |             
      Leukemia Mononuclear                 |                                                    X                 X   |             
      Polyp Stromal                        |                            X           X                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                      X   |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                    X                     |             
      Inguinal, Leukemia Mononuclear       |                                                                      X   |             
      Mandibular, Leukemia Mononuclear     |                            X                       X           X     X   |             
      Mediastinal, Leukemia Mononuclear    |                         X                                      X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                +         |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X  X                       X           X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                                    X           X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                              X     X           X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|             
                                           | 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |          X     X     X        X           X                 X        X   |             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                                                    X           X     X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
      Squamous Cell Carcinoma              |                                                                          |             
      Trichoepithelioma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                            +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X           X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |                         X  X                       X           X     X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nares, Leukemia Mononuclear          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                          +     +         |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                    +  +                                             |             
      Lids, Fibrosarcoma                   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X           X     X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X           X     X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                       X  X                       X           X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X  X        X        X        X  X  X                  |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |                               X                 X  X                     |          6 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                 X  X                     |          5 |
      Pheochromocytoma Benign              |                               X        X  X                              |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |       X     X  X     X  X  X  X        X  X  X                 X         |         25 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |       X        X                 X              X  X           X        X|         12 |
      C-Cell, Carcinoma                    |                                           X           X                  |          2 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Adenoma                              |             X                 X                                X         |          4 |
      Carcinoma                            |                   X                                                      |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Polyp Stromal                        |             X                 X     X                             X      |          6 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |          +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                       X                  |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |                   X  X        X        X        X                        |          9 |
      Mediastinal, Leukemia Mononuclear    |                                                 X  X                     |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X  X        X        X        X  X  X                  |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                   X                             X  X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          3 |
      Adenoma                              |                X                                                         |          1 |
      Fibroadenoma                         | X  X  X                    X     X     X              X        X  X      |         16 |
      Fibroadenoma, Multiple               |                                                                         X|          1 |
      Leukemia Mononuclear                 |                                                 X                        |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      |                            X                                             |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                          X               |          1 |
      Trichoepithelioma                    |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |          1 |
      Leukemia Mononuclear                 |                   X  X        X        X        X  X                     |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nares, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3|            |
                                           | 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +                    +     +                    +              +|   9        |
      Lids, Fibrosarcoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                 +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                 X                        |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X  X        X        X        X  X  X                  |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X           X                          X  X  X  X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Carcinoma, Metastatic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +        +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Pars Distalis, Adenoma               | X  X     X  X  X  X  X  X  X  X     X  X  X  X              X        X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                        X     X  X           X        X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +     +     +        +  +     M     +  +  +  +           +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +     +        +  +  +  +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +  +  +  +  +     +     +  +  +  +           +        +   |             
      Polyp Stromal                        |    X  X           X                                                      |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +        +  +     +     +  +  +  +           +        +   |             
      Deep Cervical, Leukemia Mononuclear  |    X                                                                     |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |    X        X                                               X            |             
      Mediastinal, Leukemia Mononuclear    |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +        +  +     +     +  +  +  +  +     +  +        +   |             
      Leukemia Mononuclear                 |    X     X  X           X                 X        X     X  X            |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +     +        I  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +        +  +  +  +     +  +  +  +           +        +   |             
      Adenocarcinoma                       | X                                                           X            |             
      Adenoma                              |             X                                                            |             
      Fibroadenoma                         |          X     X        X     X  X     X  X                          X   |             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |       X                                                                  |             
      Subcutaneous Tissue, Fibrosarcoma    |                            X                                             |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|             
                                           | 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +     +        +  +     +     +  +  +  +           +  +     +   |             
      Leukemia Mononuclear                 |    X     X                                X                 X            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +     +        +  +     +     +  +  +  +           +        +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +     +        +  +     +     +  +  +  +           +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +              +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +        +  +     +     +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +     +        +  +     +  +  +  +  +  +           +        +   |             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X           X                 X        X  X  X  X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                   +  +  +           +  +     +           +     +        +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                   +  +  +           +  +     +           +     A        +|  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                 X        X                    X  X  X|         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                 +     +  +  +                                         +|   6        |
      Leukemia Mononuclear                 |                   X                                                     X|          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                   +  +  +           +  +     +           +     A        +|  20        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                   +  +  +           +  +     +           +     +        +|  21        |
      Carcinoma, Metastatic                |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                   +  +  +           +  +     +           +     A        +|  20        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                   +  +  +           +  +     +           +     A        +|  20        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                   +  +  +           +  +     +           +     +        +|  21        |
      Leukemia Mononuclear                 |                   X                 X                                   X|          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                   +  +  +           +  +     +        +  +     A        +|  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                   +  +  +           +  +     +        +  +     A        +|  21        |
      Leukemia Mononuclear                 |                   X                 X                                   X|          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                   +  +  +           +  +     +        +  +     A        +|  21        |
      Leukemia Mononuclear                 |                   X                 X                                   X|          4 |
      Pheochromocytoma Malignant           |                                                       X                  |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                   +  +  +           +  +     +           +     A        +|  20        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                   M  +  +           +  +     +           +     M        +|  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +     +|  41        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                   X                                                     X|          3 |
      Pars Distalis, Adenoma               |             X  X  X        X  X        X           X  X           X      |         26 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                   +  +  +           +  +     +           +     A        +|  20        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
      C-Cell, Adenoma                      |                                        X                                X|          7 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                   +  +  +           +  +     I           +     +        +|  21        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                 +  +  +           +  +     +           +     +        +|  23        |
      Leukemia Mononuclear                 |                   X                                                     X|          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +           +  +     +     +     +     +        +|  26        |
      Polyp Stromal                        |                                     X                                    |          4 |
      Polyp Stromal, Multiple              |                                              X                           |          1 |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                   +  +  +           +  +     +           +     +        +|  21        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +  +           +  +     +           +     A        +|  21        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                         X|          1 |
      Mandibular, Leukemia Mononuclear     |                   X                 X        X                          X|          7 |
      Mediastinal, Leukemia Mononuclear    |                   X                 X        X                          X|          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                   +  +  +           +  +     +           +     +  +  +  +|  26        |
      Leukemia Mononuclear                 |                   X                 X        X                 X  X  X  X|         15 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                   +  +  +           M  +     +           I     +        +|  18        |
      Leukemia Mononuclear                 |                                              X                 X        X|          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                   +  +  +           +  +     +           +  +  A        +|  24        |
      Adenocarcinoma                       |                         X                                                |          3 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                                                             X            |          9 |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1|            |
                                           | 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                   +  +  +           +  +     +           +     +        +|  22        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                   +  +  +           +  +     +           +     +        +|  21        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                   +  +  +           +  +     +           +     +        +|  21        |
      Leukemia Mononuclear                 |                                                                X         |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                   +  +  +           +  +     +           +     +        +|  22        |
      Leukemia Mononuclear                 |                   X                 X        X                 X        X|          9 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                   +  +  +           +  +     +           +     +        +|  21        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                   +  +  +           +  +     +           +     +        +|  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                      +  +                 +   |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   1        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                          +               |   1        |
      Carcinoma                            |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                   +  +  +           +  +     +           +     +        +|  21        |
      Leukemia Mononuclear                 |                   X                          X                          X|          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                   +  +  +           +  +     +           +     A        +|  21        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                 X        X                 X  X  X  X|         16 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                   +     +        +  +  +     A  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                   +     +        +  +  +     A  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +     +        +  +  +     A  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X           X        X              X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                   +     +        +  +  +     A  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                   +     +  +     +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X                                               X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                   +     +        +  +  +     +  +        +  +     +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Pars Distalis, Adenoma               | X                 X  X     X                 X                       X   |             
      Pars Distalis, Leukemia Mononuclear  |                         X              X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +     +        +  +  +     A  +        +  +     +     +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                   X              X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                   +     +  +     +  +  +     +  +        +  +     +     +|             
      Adenoma                              |                            X                    X                 X      |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Uterus                                  |                   +     +        +  +  +  +  +  +        +  +     +     +|             
      Leiomyosarcoma                       |                                           X                              |             
      Polyp Stromal                        |                   X                                                      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                   +     +        +  +  +     +  +        +  +     +     I|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +     +        +  +  +     +  +        +  +     +     +|             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                         X              X                                X|             
      Mediastinal, Leukemia Mononuclear    |                         X                                               X|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +     +        +  +  +     A  +     +  +  +     +     +|             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 |                X        X              X        X     X                 X|             
                                            __________________________________________________________________________|             
   Thymus                                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                 +     +  +     +  +  +  +  +  +        +  +  +  +  +  +|             
      Fibroadenoma                         | X                 X        X              X  X              X  X     X   |             
                                            __________________________________________________________________________|             
   Skin                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                   +     +        +  +  +     +  +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X              X        X                       X|             
                                            __________________________________________________________________________|             
   Nose                                    |                   +     +        +  +  +     +  +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |                   +     +        +  +  +     +  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +     +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|             
                             DAY ON TEST   | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|             
                                           | 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
      Carcinoma                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                   +     +        +  +  +     +  +        +  +     +     +|             
      Leukemia Mononuclear                 |                         X                                               X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                   +     +        +  +  +     A  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X  X           X        X     X        X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +  +  +  +     +  +           +           +     +         |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
      Leukemia Mononuclear                 |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X  X  X  X           X           X     X  X     X        X  X  X|         20 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +           +  +  +  +     +  +           +  +        +     +         |  22        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +  A  +  +  +     +  +           +  +        +     A         |  20        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
      Leukemia Mononuclear                 |    X        X                                   X        X               |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                   X           X                 X                        |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                   X                             X                        |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Adenoma                              |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M        +  +  +  +  +     +  +           +  M        +     +         |  21        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +   |  43        |
      Leukemia Mononuclear                 |                                                                   X      |          2 |
      Pars Distalis, Adenoma               | X                       X           X  X  X              X  X  X     X   |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +  A  +  +  +     +  +           +  +        A     A         |  19        |
      Bilateral, C-Cell, Adenoma           |                                              X                           |          1 |
      C-Cell, Adenoma                      |                   X           X                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
      Adenoma                              |                      X                                                   |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +        +  +  +  +  +     +  +  +        +  +        +  +  +         |  26        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +  +  +  +  +  +     +  +        +  +  +        +     +         |  26        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Polyp Stromal                        |          X           X        X           X  X                           |          6 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +  +  +  +  +     +  +           +  +        +     +         |  22        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +  +  +  +     +  +        +  +  +        +     +  +  +   |  26        |
      Deep Cervical, Leukemia Mononuclear  |    X                                                                     |          1 |
      Mandibular, Leukemia Mononuclear     |    X        X  X  X           X                 X        X        X      |         11 |
      Mediastinal, Leukemia Mononuclear    |             X  X              X                 X                        |          6 |
      Pancreatic, Leukemia Mononuclear     |                X              X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                               +           +                          +   |   4        |
      Leukemia Mononuclear                 |                               X           X                          X   |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +  +  +  +  +     +  +        +  +  +  +     +     +  +  +   |  29        |
      Hemangioma                           |                                                                X         |          1 |
      Leukemia Mononuclear                 |    X     X  X  X  X           X           X     X  X     X        X  X   |         18 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +  M  +  +  +     +              +  +        +     +         |  21        |
      Leukemia Mononuclear                 |    X        X                 X                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +        +  +  +  +  +     +  +        +  +  +        +  +  +     +   |  31        |
      Fibroadenoma                         |                      X  X        X        X                 X        X   |         14 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  24        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3|            |
                                           | 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +  +  +  +     +  +           +  +        +     +  +      |  24        |
      Leukemia Mononuclear                 |    X        X  X  X           X                          X        X      |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +  +  +  +  +     +              +  +        +     +         |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +        +                                               +            |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +  +  +  +     +  +           +  +        +     +         |  23        |
      Leukemia Mononuclear                 |                X              X                 X        X               |          6 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +        +  +  +  +  +     +              +  +        +     A         |  20        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X  X  X  X           X           X     X  X     X        X  X  X|         21 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                    +  A           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +                    +  A           A  +     +                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +                    +  A           A  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |    X                                                                     |             
      Leukemia Mononuclear                 |                      X     X  X                 X  X              X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                    +  A           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                    +  A           +  +     +                    +|             
      Adenoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +  +        +  +  +  +     +  +     +  +              +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Pars Distalis, Adenoma               | X     X        X  X        X     X  X        X     X  X                  |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +                    +  A           A  +     +                    +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       M           +        +  +           +  +     +                    +|             
      Adenoma                              |                                                                          |             
      Squamous Cell Papilloma              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +                    +  +           +  +     +  +           +     +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +           +        +  +        +  +  +     +  +              +  +|             
      Polyp Stromal                        | X                                      X  X           X              X   |             
      Sarcoma Stromal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                    +  A           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                    +  A           +  +     +                    +|             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                            X                                             |             
      Mediastinal, Leukemia Mononuclear    |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +              +     +  +           +  +  +  +                 +  +|             
      Leukemia Mononuclear                 |                      X     X  X                 X                    X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +                    +  A           +  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +           +        +  +           +  +     +                    +|             
      Adenocarcinoma                       |       X                                                                  |             
      Fibroadenoma                         |    X              X                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    |       +                    +  +           +  +     +              +     +|             
      Squamous Cell Papilloma              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                    +  +           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                            X  X                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |       +                    +  +           +  +     +                    +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                    +  +           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Sarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                         +  +        +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                         +|             
      Carcinoma                            |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +                    +  +           +  +     +                    +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +                    +  A           +  +     +                    +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X  X                 X  X              X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A           +                       A                       +      |  10        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A           +                       A                       +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A           +                       A                       +      |   9        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |                   X                    X                 X               |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A           +                       A                       +      |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +           +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  A  +        +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A           +                       +                       +      |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +        +                       A                       +      |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +           +                       +                       +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +           +                       +                       +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +           +                       +                       +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A           +                       +                       +      |  11        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +           +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +        +  +     +        +     +  +  +  +  +        +  +  +  +|  32        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X  X     X                          X        X  X     X        X     X   |         19 |
      Pars Distalis, Carcinoma             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A           +                       A                       +      |   9        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +           +        +           +  M                       +      |  14        |
      Adenoma                              |                            X                                      X      |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +           +     +        +  +     +                       +      |  19        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +     +  +  +     +  +        +        +     +        +      |  25        |
      Polyp Stromal                        |             X     X  X  X        X                       X               |         11 |
      Sarcoma Stromal                      | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +           +                       +                       +      |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +           +                       +                       +      |  12        |
      Inguinal, Leukemia Mononuclear       |                   X                                                      |          1 |
      Mandibular, Leukemia Mononuclear     |                   X                                                      |          2 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A           +                       +              +        +  +   |  17        |
      Leukemia Mononuclear                 |                   X                                      X               |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +           +                       +                       +      |  12        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +           +        +           +  +     +           +     +      |  19        |
      Adenocarcinoma                       |                                                 X                        |          2 |
      Fibroadenoma                         |                   X        X           X                    X            |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +           +                       +                       +      |  14        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3|            |
                                           | 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +           +                       +                       +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +           +                       +                       +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +           +                       +                       +      |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +              +                       +                       +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
      Pinna, Sarcoma                       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +  +                                         +                  |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  A           +                       +           +           +      |  13        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A           +                       +                       +      |  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                    X                 X               |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A     +        +  +                 +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Submucosa, Leukemia Mononuclear      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma, Multiple     |                                                                X         |             
      Leukemia Mononuclear                 |                X                          X                       X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +        +  +                 +  +        +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Endocardium, Schwannoma Benign       |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +        +  +  +              +  +        A        +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +        +  +  +              +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Pheochromocytoma Benign              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +        +  +                 +  +        A        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +        +  +                 +  +        +        +  +     +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | A  +  +  +  +  +  +        +  +  +  +  +        +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X     X  X     X                 X           X           X        X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                                          X              X|             
      Follicular Cell, Adenocarcinoma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +        +  +     +           +  +        +        +  +     +     M|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +     +  +     +           +  +        +        +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +     +  +  +     +        +  +  +  +  +        +  +  +  +  +  +|             
      Adenocarcinoma                       |                                        X                                 |             
      Leiomyoma                            |                                                                X         |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        | X        X        X        X                             X              X|             
      Sarcoma Stromal                      |                      X                                                   |             
      Cervix, Carcinoma Adenosquamous      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                      +           +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +        +  +                 +  +        +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +  +              +  +        +        +  +     +     +|             
      Deep Cervical, Leukemia Mononuclear  |                X                                                         |             
      Mandibular, Leukemia Mononuclear     |                X                                                  X     X|             
      Mediastinal, Leukemia Mononuclear    |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +     +                                                  +|             
      Leukemia Mononuclear                 |                X                                                        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                X                                                  X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +        +  M                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +        +  +                 +  +        +        +  +     +  +  +|             
      Adenoma                              |                                                                      X   |             
      Fibroadenoma                         |                   X                                                     X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +              +  +     +  +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|             
                             DAY ON TEST   | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|             
                                           | 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Keratoacanthoma                      |                X                                                         |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |    X                                         X                           |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +        +  +                 +  +        +        +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                X                                                  X     X|             
                                            __________________________________________________________________________|             
   Nose                                    | +     +        +  +                 +  +        +        +  +     +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Sarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +        +                          +           +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +        +  +                 +  +        +        +  +     +     +|             
      Leukemia Mononuclear                 |                X                                                        X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A     +        +  +                 +  +        A        +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                          X                       X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                       +  +  +        +  +     +        +  +     +   |  19        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 | X                                         X                              |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Submucosa, Leukemia Mononuclear      | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 | X                             X           X  X           X     X         |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                       +  +  +        +  +     +        +  +     +   |  21        |
      Leukemia Mononuclear                 | X                                         X  X                           |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                            X                           |          3 |
      Endocardium, Schwannoma Benign       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +                       +  +  +        +  +              +  +     +   |  20        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 |                                              X                 X         |          3 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                       +  +  +        +  +     +        +  +     +   |  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +                       +  +  M        +  +     +        +  M     +   |  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +        +  +  +        +  M  +  +  +     +  +     +  +|  35        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Pars Distalis, Adenoma               |          X     X  X        X                       X                 X  X|         15 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
      C-Cell, Adenoma                      |                                                                      X   |          3 |
      Follicular Cell, Adenocarcinoma      | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +        +              +  +  +     +  +  +     +        +  +     +   |  24        |
      Adenoma                              |             X                    X     X                    X            |          4 |
      Leukemia Mononuclear                 | X                                         X                              |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +        +              +  +  +        +  +     +        +  +     +   |  26        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +              +  +  +  +     +  +  +  +     +  +  +     +   |  35        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leiomyoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Polyp Stromal                        |    X  X     X                 X                 X  X        X            |         13 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Cervix, Carcinoma Adenosquamous      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                      +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +                       +  +  +        +  +     +        +  +     +   |  23        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     | X                             X           X  X                 X         |          8 |
      Mediastinal, Leukemia Mononuclear    |                               X           X  X                 X         |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                               +           +  +                           |   6        |
      Leukemia Mononuclear                 |                               X           X  X                           |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                       +  +  +        +  +     +     +  +  +     +   |  22        |
      Leukemia Mononuclear                 | X                             X           X  X           X     X         |          9 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M                       +  +  +        +  +     +           +     +   |  19        |
      Leukemia Mononuclear                 | X                             X           X  X                           |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +              +  +     +  +  +        +  +     +        +  +     +   |  25        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                   X  X     X                       X                     |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                       +  +  +  +     +  +     +        +  +     +   |  26        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                                        |          1 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                              X                           |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                         X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                    +  +  +  +        +  +     +        +  +     +   |  23        |
      Leukemia Mononuclear                 | X                             X           X  X                 X         |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                               +                                          |   1        |
      Pinna, Sarcoma                       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                         +        +            |   7        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                       +  +  +        +  +     +        +  +     +   |  22        |
      Leukemia Mononuclear                 |                                           X  X                 X         |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3|            |
                                           | 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                       +  +  +        +  +     +        +  +     +   |  20        |
      Leukemia Mononuclear                 | X                                         X                              |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                             X           X  X           X     X         |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +  A        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +  A        +           +     +  +     +  +     +  +         |             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                     X     X           X                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X              X     X     X           X     X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                |             A  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                     X     X           X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Squamous Cell Carcinoma              |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |             X                       X     X           X     X            |             
      Pericardium, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +  +        +           +     +  +     +  +     +  +         |             
      Carcinoma                            |                                              X                           |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                     X                 X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             A  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +     +  +  +        +     +  +  +  +  +  +  +  +     +   |             
      Leukemia Mononuclear                 |                                           X           X                  |             
      Pars Distalis, Adenoma               |          X           X  X  X              X              X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +  A        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |                                     X                                    |             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          +  +  +        +     +     +     +  +     +  +  +  +  +         |             
      Carcinoma                            |          X                                                               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +  +     +  +     +     +     +  +     +  +        +     +   |             
      Leukemia Mononuclear                 |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +  +  +  +  +        +  +  +  +  +     +  +     +  +  +      |             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        | X                 X  X                 X                    X     X      |             
      Sarcoma Stromal                      |                                                    X                     |             
      Wall, Leukemia Mononuclear           |                                           X                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                 +                    +                    +  +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +        +     +     +     +  +     +  +     +  +        +|             
      Deep Cervical, Leukemia Mononuclear  |                                                       X                  |             
      Inguinal, Leukemia Mononuclear       |                                           X                              |             
      Lumbar, Leukemia Mononuclear         |                                                       X                  |             
      Mandibular, Leukemia Mononuclear     |             X                       X     X           X     X            |             
      Mediastinal, Leukemia Mononuclear    |             X                             X           X                  |             
      Renal, Leukemia Mononuclear          |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                       +           +           +        +         |             
      Leukemia Mononuclear                 |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +  +        +     +     +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |             X  X              X     X     X           X     X            |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |             X                       X     X           X     X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|             
                                           | 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +        +           +     +  +  +  +  +     +  +         |             
      Fibroadenoma                         |                                                 X     X                  |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +        +        +  +     +  +     +  +     +  +         |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +        +           +     +  +     +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +  +        +           +     +  +     +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +        +           +     +  +     +  +     +  +         |             
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |             
      Carcinoma, Metastatic, Adrenal Gland |                                              X                           |             
      Leukemia Mononuclear                 |             X  X                    X     X           X     X            |             
      Sarcoma, Metastatic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +        +           +     +  +     +  +     +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +        +           +     +  +     +  +     +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +                       +                    +     +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +  +        +           +     +  +     +  +     +  +         |             
      Leukemia Mononuclear                 |             X                       X     X           X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +  +        +           +     +  +     +  +     M  +         |             
      Leukemia Mononuclear                 |                                     X                 X                  |             
      Wall, Leukemia Mononuclear           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X              X     X     X           X     X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +     +                          +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +                                +     +           +  +  A      |  15        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +     +                          +     +           +  +  +      |  17        |
      Adenocarcinoma                       |                X                                                         |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X  X  X                          X              X  X           X|         14 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +            |   2        |
      Leukemia Mononuclear                 |                                                             X            |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                             X            |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +                                +     +           +  +  +      |  17        |
      Leukemia Mononuclear                 |                                                             X            |          6 |
      Pericardium, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +                                +     +           +  +  +      |  17        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +                                +     +           +  +  +      |  17        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                             X            |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +                                +     +           +  +  +      |  17        |
      Leukemia Mononuclear                 |                                                             X            |          4 |
      Pheochromocytoma Benign              |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +                                +     +           +  +  +      |  16        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +              +  +     +  +     +     +  +  +  +  +  +  +  +   |  33        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |    X     X              X           X              X           X     X   |         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +                                +     +           +  +  +     +|  17        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                           X                             X|          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +     +                                +     +           +  +  +      |  20        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +           +                    +     +           +  +  +      |  21        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +  +     +     +        +  +     +           +  +  +     +|  31        |
      Adenocarcinoma                       |                                                 X                        |          1 |
      Leukemia Mononuclear                 |                                                                         X|          1 |
      Polyp Stromal                        |                X  X     X     X                 X                        |         11 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Wall, Leukemia Mononuclear           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                               +                                         +|   7        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +     +                          +     +           +  +  +     +|  22        |
      Deep Cervical, Leukemia Mononuclear  |                                                                         X|          2 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |                                           X                 X           X|          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear    |                                           X                 X           X|          6 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                         +|   6        |
      Leukemia Mononuclear                 |                                                                         X|          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +  +                          +     +           +  +  +     +|  21        |
      Leukemia Mononuclear                 |          X  X  X                          X                 X           X|         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +                                +     +           +  +  +     M|  17        |
      Leukemia Mononuclear                 |                                                             X            |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +     +  +  +     +        +     +     +           +  +  +      |  23        |
      Fibroadenoma                         |                X  X  X                                         X         |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +                                +     +           +  +  +      |  18        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +                                +     +           +  +  +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +                                +     +           +  +  +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +                                +     +           +  +  +     +|  18        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                 X           X|          9 |
      Sarcoma, Metastatic                  |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +                                +     +           +  +  +      |  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +                                +     +           +  +  +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +        +                 +                                   +|   9        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +                                +     +           +  +  +      |  17        |
      Leukemia Mononuclear                 |                                                             X            |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +                                +     +           +  +  +      |  16        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Wall, Leukemia Mononuclear           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3|            |
                                           | 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X  X  X                          X              X  X           X|         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |    X                                                                     |             
      Leukemia Mononuclear                 |          X                 X                    X              X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X  X  X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X  X   |             
      Endocardium, Schwannoma Benign       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X     X           X     X  X     X     X  X  X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                         X           X                       X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Polyp Stromal                        |                   X        X  X                 X  X                 X   |             
      Endometrium, Adenoma                 |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |          X           X     X                    X              X  X  X   |             
      Mediastinal, Leukemia Mononuclear    |          X           X     X                    X                 X  X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                       +           +      |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                    X              X  X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                 X  X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                  X              X                        |             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|             
                                           | 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Abdominal, Ventral, Leukemia         |                                                                          |             
          Mononuclear                      |                                                                      X   |             
      Head, Leukemia Mononuclear           |                                                                      X   |             
      Neck, Leukemia Mononuclear           |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                       X                  |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                             X            |             
      Leukemia Mononuclear                 |          X           X     X                    X              X  X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nerve, Leukemia Mononuclear          |                                                                      X   |             
      Sinus, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                    +     +              +        +  +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +     +              +     +        +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +            |             
      Carcinoma                            |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X     X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X     X                    X              X  X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X  X                                X        X  X               |         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +              +            |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                         X  X               |          5 |
      Endocardium, Schwannoma Benign       |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                         X  X               |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                                         X  X               |          4 |
      Pheochromocytoma Benign              |                                                    X                    X|          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |                      X        X     X     X                              |         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Bilateral, C-Cell, Adenoma           |                   X                                                      |          1 |
      C-Cell, Adenoma                      |                                                    X                     |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              | X                                                                        |          1 |
      Carcinoma                            |                                  X                                       |          1 |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                              X        X  X               |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X  X               |          3 |
      Polyp Stromal                        |             X  X              X     X           X                 X      |         12 |
      Endometrium, Adenoma                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                      +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Deep Cervical, Leukemia Mononuclear  |                                                       X                  |          1 |
      Inguinal, Leukemia Mononuclear       |                                              X                           |          1 |
      Mandibular, Leukemia Mononuclear     |       X  X  X                                X        X  X               |         13 |
      Mediastinal, Leukemia Mononuclear    |          X  X                                X        X  X               |         11 |
      Pancreatic, Leukemia Mononuclear     |                                              X        X                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                              +           +               |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                              X           X               |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X  X                                X        X  X               |         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Leukemia Mononuclear                 |          X  X                                X        X  X               |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroadenoma                         |                   X                    X                                 |          4 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Ventral, Leukemia         |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
      Head, Leukemia Mononuclear           |                                                                          |          1 |
      Neck, Leukemia Mononuclear           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X  X                                X        X  X               |         13 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nerve, Leukemia Mononuclear          |                                                                          |          1 |
      Sinus, Leukemia Mononuclear          |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                    +                                       |   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3|            |
                                           | 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                +               |   7        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X  X                                X        X  X               |          7 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X  X                                X        X  X               |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Benign              |    X                          X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X        X                                X        X           X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                               X                                   X  X   |             
      Follicular Cell, Adenocarcinoma      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |       X  X                                            X              X   |             
      Sarcoma Stromal                      |                               X                                          |             
      Endometrium, Adenocarcinoma          |                                                                          |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |                                                       X              X   |             
      Mediastinal, Leukemia Mononuclear    |                                                       X              X   |             
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                       X              X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Spinal, Schwannoma Malignant         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|             
                                           | 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                      +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X        X  X                       X           X         |          8 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   1        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X              X                                   X         |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                      X                     |          3 |
      Pheochromocytoma Benign              |                               X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |                         X     X     X           X  X                 X  X|         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, C-Cell, Adenoma           |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |                                                                      X   |          4 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Carcinoma                            |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Stromal                        |          X                                      X                        |          6 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Endometrium, Adenocarcinoma          |                                  X                                       |          1 |
      Endometrium, Sarcoma Stromal         |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                     +                                    |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Leukemia Mononuclear     |             X  X           X                       X           X         |          7 |
      Mediastinal, Leukemia Mononuclear    |             X  X                                   X                     |          5 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +  +                                               +         |   3        |
      Leukemia Mononuclear                 |             X  X                                               X         |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X        X  X                       X           X         |          8 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |             X  X                                   X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibroadenoma                         |                                                                X  X      |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5|            |
                             DAY ON TEST   | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8|            |
                                           | 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                         +|   1        |
      Spinal, Schwannoma Malignant         |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X        X  X                       X           X         |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                       +        +        +|   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                    +                                 |   4        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                +                                    |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X  X        X  X                       X           X         |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|             
      Leukemia Mononuclear                 |                                     X                 X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                             X            |             
      Leukemia Mononuclear                 | X     X              X           X  X  X        X     X           X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                        +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Squamous Cell Carcinoma              |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X           X  X                 X           X      |             
      Schwannoma Benign                    |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Capsule, Mesothelioma     |                                                                          |             
          Malignant                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                  X  X  X              X           X  X  X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X  X                 X           X  X  X|             
      Pheochromocytoma Benign              |    X     X     X  X        X     X  X     X                              |             
      Bilateral, Pheochromocytoma Benign   | X                    X                       X                 X     X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X     X  X     X                    X  X                    X         |             
      Pars Nervosa, Histiocytic Sarcoma    |                                                             X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                      X     X                    X                        |             
      C-Cell, Adenoma                      |       X                       X  X                 X        X        X   |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenocarcinoma      |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X                                                |             
      Carcinoma                            |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +                                         +                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X  X        X  X  X  X  X  X  X  X     X  X  X  X  X     X  X  X  X  X|             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                                                          |             
      Interstitial Cell, Adenoma           |          X  X                                            X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Histiocytic Sarcoma         |                                                             X            |             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mandibular, Histiocytic Sarcoma      |                                                             X            |             
      Mandibular, Leukemia Mononuclear     | X     X                          X  X  X        X     X           X     X|             
      Mediastinal, Leukemia Mononuclear    | X     X              X              X  X        X     X           X      |             
      Pancreatic, Leukemia Mononuclear     |       X                                                                 X|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X     X              X           X  X  X        X     X           X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  M  M  +  +  +|             
      Leukemia Mononuclear                 |       X                          X  X  X        X     X           X  X  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +                 +  +     +           +  +  +  +  +  +  +      |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |                            X                             X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                      X   |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Benign                   |                                                       X                  |             
      Histiocytic Sarcoma                  |                                                             X            |             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma                            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|             
                                           | 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                             X            |             
      Leukemia Mononuclear                 | X     X              X           X  X  X        X     X           X  X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp                                |                                                                          |             
      Nares, Leukemia Mononuclear          |                                                                          |             
      Nasolacrimal Duct, Histiocytic       |                                                                          |             
          Sarcoma                          |                                                             X            |             
      Sinus, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +              +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X           X  X  X        X     X              X  X|             
      Sarcoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                             X            |             
      Leukemia Mononuclear                 | X     X              X           X  X  X        X     X           X  X  X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mesothelioma Malignant               |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                X     X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                      X                                                   |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X           X  X  X   |         25 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +              +                       +  +              +   |   7        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      Mesothelioma Malignant               |                            X                          X                  |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                       X                           |          3 |
      Mesothelioma Malignant               |                            X                          X                  |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X  X     X     X        X              X     X                 X   |         14 |
      Schwannoma Benign                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Capsule, Mesothelioma     |                                                                          |            |
          Malignant                        |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X              X                 X   |         18 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X  X  X     X     X  X     X              X                 X   |         16 |
      Pheochromocytoma Benign              |       X                             X     X              X              X|         13 |
      Bilateral, Pheochromocytoma Benign   |                                                 X                        |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |          X                          X        X                           |          3 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X     X     X                                                   |          3 |
      Pars Distalis, Adenoma               | X     X                          X     X        X     X                  |         14 |
      Pars Nervosa, Histiocytic Sarcoma    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      Bilateral, C-Cell, Adenoma           |                                                                          |          3 |
      C-Cell, Adenoma                      |                                           X                       X      |          8 |
      C-Cell, Carcinoma                    | X                                                                        |          1 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mesothelioma Malignant               |                                                       X                  |          1 |
      Bilateral, Mesothelioma Malignant    |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                      X   |          2 |
      Carcinoma                            |                                                             X            |          2 |
      Leukemia Mononuclear                 |             X        X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                      +   |   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X     X  X|         42 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                            X                          X                  |          2 |
      Interstitial Cell, Adenoma           |                                                                   X      |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Histiocytic Sarcoma         |                                                                          |          1 |
      Femoral, Leukemia Mononuclear        |          X           X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Deep Cervical, Leukemia Mononuclear  |             X        X                                                   |          2 |
      Inguinal, Leukemia Mononuclear       |    X                                                                     |          1 |
      Lumbar, Leukemia Mononuclear         |                      X                                                   |          1 |
      Mandibular, Histiocytic Sarcoma      |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |    X     X  X  X     X     X  X     X        X     X              X  X   |         21 |
      Mediastinal, Leukemia Mononuclear    |    X  X  X  X  X     X     X  X              X     X                 X   |         19 |
      Pancreatic, Leukemia Mononuclear     |    X                       X        X                                    |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                                   +  +        +                     |   5        |
      Leukemia Mononuclear                 |    X                                               X                     |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X           X  X  X   |         25 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M|  40        |
      Leukemia Mononuclear                 |    X     X     X           X  X     X        X     X                 X   |         18 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +           +     +     +  +     +  +           +           +  +     +|  23        |
      Adenocarcinoma                       |                            X                                             |          1 |
      Fibroadenoma                         |                                                                X         |          3 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Keratoacanthoma                      |                               X                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Squamous Cell Carcinoma              |                                        X                                 |          2 |
      Subcutaneous Tissue, Fibroma         |                         X                                                |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Benign                   |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |             X  X                                                         |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |          1 |
      Carcinoma                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X                 X   |         23 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp                                |                                                                         X|          1 |
      Nares, Leukemia Mononuclear          |                      X                                                   |          1 |
      Nasolacrimal Duct, Histiocytic       |                                                                          |            |
          Sarcoma                          |                                                                          |          1 |
      Sinus, Leukemia Mononuclear          |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                +         |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +        +  +  +                          +           +        +         |   9        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                               +   |   2        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X                 X   |         21 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7|            |
                             DAY ON TEST   | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4|            |
                                           | 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
      Mesothelioma Malignant               |                                                       X                  |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X  X  X     X     X  X     X        X     X           X  X  X   |         25 |
      Mesothelioma Malignant               |                            X                          X                  |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
      Lymphoid Nodule, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
      Lymphoid Nodule, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +  +  +     A     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Peyer's Patch, Leukemia Mononuclear  |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +  A  +     A     +  +  +     A     +              +  +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               | X                                                                        |             
      Leukemia Mononuclear                 | X                 X     X  X     X  X           X  X                 X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +  +      |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +           +  +  +     +     +  +  +     A     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +           +  +        +     +  +  +     A     +              +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +           +  A        +     +  +  +     A     +              +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +           +  +  +     +     +  +  +     +  +  +              +  +  +  +|             
      Leukemia Mononuclear                 | X                       X                       X                    X  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X        X  X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X  X                                    |             
      Pheochromocytoma Malignant           |                X                                                         |             
      Pheochromocytoma Benign              |    X     X                 X                       X           X  X      |             
      Bilateral, Pheochromocytoma Benign   |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +     +     +  +  +     +     +     +        +  +  +  +|             
      Pars Distalis, Adenoma               |             X                                                            |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +  A  +     A     +  +  +     A  +  +              +  +  +  +|             
      C-Cell, Adenoma                      |                   X           X     X           X                    X   |             
      C-Cell, Carcinoma                    |                                              X                           |             
      Follicular Cell, Adenocarcinoma      |          X                                                        X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +           +  +  +     +  +  +  +  +     +     +              +  M  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                         X           X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X   |             
      Interstitial Cell, Adenoma           |                                           X                             X|             
      Tunic, Mesothelioma Malignant        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +           +  +  +     A     +  +  +     +     +              +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                     X                                    |             
      Mandibular, Leukemia Mononuclear     |                         X        X  X           X                    X  X|             
      Mediastinal, Leukemia Mononuclear    |                                  X  X           X                       X|             
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |             
      Renal, Leukemia Mononuclear          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +     +  +                                +      |             
      Leukemia Mononuclear                 |                         X        X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +  +     +  +  +  +  +  +  +     +              +  +  +  +|             
      Leukemia Mononuclear                 | X                 X     X  X     X  X  X        X                    X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Capsule, Mesothelioma Malignant      |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +           +  +  +     +     +  +  +     +     +              +  +  M  +|             
      Leukemia Mononuclear                 |                         X        X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +     +           +                 +                    +   |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Osteosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Astrocytoma Malignant                | X                                                                        |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Leukemia Mononuclear                 |                   X     X        X  X           X                    X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +           +  +  +     +     +  +  +     +     +              +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X        X  X           X                    X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +  +  +     A     +  +  +     +     +              +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|             
                                           | 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X                 X     X  X     X  X  X        X  X                 X  X|             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +        +  A  +              +     +     +  +  A        +  +  +|  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +        +  +  +              M     +     +  +  +        +  +  +|  24        |
      Lymphoid Nodule, Leukemia Mononuclear|                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +        +  +  +              +     +     +  +  +        +  +  +|  24        |
      Lymphoid Nodule, Leukemia Mononuclear|                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +        +  +  +              +     +     +  +  +        +  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +        +  A  +              +     +     +  +  A        +  +  +|  22        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Peyer's Patch, Leukemia Mononuclear  |                                                       X           X      |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  24        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Peyer's Patch, Leukemia Mononuclear  |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X  X     X  X  X  X              X           X  X  X        X  X   |         23 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   3        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  26        |
      Squamous Cell Papilloma              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  25        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +        +  +  +              +     +     +  +  +        +  +  +|  28        |
      Leukemia Mononuclear                 |          X        X  X  X              X           X     X           X   |         13 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X        X  X                 X           X  X  X           X   |         11 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  67                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X        X  X                             X  X              X   |          8 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |          X     X     X                       X                          X|         11 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Adenoma                              |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +        +  M  +              +     +     +  +  +        +  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +     +        +  +  +     +  +  +  +     +  +  +|  34        |
      Pars Distalis, Adenoma               |             X  X              X        X  X  X     X  X     X            |         10 |
      Pars Distalis, Leukemia Mononuclear  |                   X     X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      C-Cell, Adenoma                      |                      X                 X     X     X              X     X|         11 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                       X                  |          1 |
      Leukemia Mononuclear                 |       X  X           X                 X                 X               |          7 |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X     X  X  X  X  X  X|         45 |
      Interstitial Cell, Adenoma           |          X                             X              X                  |          5 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      Femoral, Leukemia Mononuclear        |                      X                                   X               |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Inguinal, Leukemia Mononuclear       |                                                       X                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |       X  X        X  X  X              X           X  X  X        X  X   |         17 |
      Mediastinal, Leukemia Mononuclear    |       X  X        X  X                 X              X  X        X  X   |         13 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +                                         +                     |   7        |
      Leukemia Mononuclear                 |       X  X                                         X                     |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +     +  +  +  +              +     +     +  +  +  +     +  +  +|  33        |
      Leukemia Mononuclear                 | X     X  X     X  X  X  X              X           X  X  X  X     X  X   |         24 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  M        M  +  +              +     +     +  +  M        +  +  +|  23        |
      Leukemia Mononuclear                 |       X              X                                X                  |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +        +     +                    +     +  +                  |  12        |
      Fibroadenoma                         |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +     +  +  +  +              +     +     +  +  +        +  +  +|  29        |
      Keratoacanthoma                      |                                                                         X|          1 |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Squamous Cell Papilloma              |                X                                                         |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                         X|          1 |
      Subcutaneous Tissue, Osteosarcoma    | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |          X           X                 X                 X        X      |          5 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                              +                           |   1        |
      Schwannoma Malignant                 |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X        X  X  X              X           X  X  X        X  X   |         18 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6|            |
                                           | 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +        +  +  +              +     +     +  +  +        +  +  +|  27        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                   +                              |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +        +  +  +  +           +     +     +  +  +        +  +  +|  28        |
      Leukemia Mononuclear                 |       X  X           X  X              X           X  X  X        X  X   |         16 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +        +  +  +              +     +     +  +  +        +  +  +|  26        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X     X  X  X  X              X           X  X  X  X     X  X   |         25 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    A           +        +  +  +        A           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A           +        +  +  +        A           +        +     +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    A           +        M  +  +        A           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A           +        +  +  +        A           +        +     +  A  +|             
      Lymphoid Nodule, Leukemia Mononuclear|                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A           +        +  +  +        A           +        +     +  A  A|             
      Peyer's Patch, Leukemia Mononuclear  |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A           +        +  +  +        A           +        +     +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                    X                     |             
      Hepatocellular Adenoma               |                X                                                         |             
      Hepatocellular Adenoma, Multiple     |                      X                                                   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X  X  X  X     X  X        X     X     X  X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +              +      |             
      Leukemia Mononuclear                 |                                                    X                     |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    A  +        +        +  +  +        +           +        +     +  A  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    A           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    A           +        +  +  +        +           +        +     +  A  +|             
      Serosa, Mesothelioma Malignant       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
      Pheochromocytoma Malignant           |    X                                   X                                 |             
      Pheochromocytoma Benign              |             X  X  X     X           X                 X  X               |             
      Bilateral, Pheochromocytoma Benign   |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    A           +        +  +  +        +           +        +     +  A  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           +        +  +  +        +           +        +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +     +        +  +  +        +        +  +     +  I     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                X           X                    X        X           X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  A           +        +  +  +        A           +        +     +  A  A|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      | X                       X  X                                      X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
      Chemodectoma Benign                  |                                                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +        +  +  +        +           +        +     +  +  +|             
      Bilateral, Mesothelioma Malignant    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +        +     +        +           +        +     +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                         X                                   X            |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X  X  X  X  X     X  X  X  X  X  X     X     X     X  X      |             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                                                   X      |             
      Interstitial Cell, Adenoma           |                            X                    X     X     X            |             
      Interstitial Cell, Carcinoma         |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +        +  +  +        +           +        +     +  A  +|             
      Femoral, Histiocytic Sarcoma         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +        +  +  +        +     +     +        +     +  +  +|             
      Inguinal, Leukemia Mononuclear       |                         X                                   X            |             
      Mandibular, Histiocytic Sarcoma      |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                X        X  X                 X     X        X            |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                X        X                                   X            |             
      Renal, Leukemia Mononuclear          |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                         +     +                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  |    A           +  +  +  +  +  +  +  +  +  +  +     +        +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                X  X  X  X  X     X  X        X     X        X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|             
                                           | 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    240 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +           +                                         +   |             
      Fibroadenoma                         |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +        +  +  +        +        +  +  +     +     M  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +     +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +        +  +  +        +           +        +     +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic                |                                                                      X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                X        X  X                       X        X            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +        +  +  +        +           +        +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +        +  +  +        +           +        +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
      Leukemia Mononuclear                 |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +           +        +  +  +        +           +        +     +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    A           +        +  +  +        +           +        +     +  A  +|             
      Leukemia Mononuclear                 |                         X                          X                     |             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X  X  X  X     X  X        X     X     X  X            |             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +           +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  +  +                                   +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +           +  +  +                                   +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +                                   +           +  +|  14        |
      Lymphoid Nodule, Leukemia Mononuclear|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +                                   +           +  +|  13        |
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +                                   +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |          X     X           X  X  X                    X  X        X  X  X|         22 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   3        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +                                   +           +  +|  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +                                   +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +                                   +           +  +|  15        |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +           +  +  +                                   +           +  +|  18        |
      Leukemia Mononuclear                 |                X                                                     X   |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |          X     X           X                                         X   |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X     X           X                                             |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  74                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |             X                 X           X  X                           |         11 |
      Bilateral, Pheochromocytoma Benign   |                         X              X                 X     X         |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +                                   +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +              +                    +           +  +|  20        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
      Pars Distalis, Adenoma               |                                     X                                    |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +                                   +           +  +|  14        |
      Bilateral, C-Cell, Adenoma           |                                                          X               |          1 |
      C-Cell, Adenoma                      |                   X                                                     X|          6 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                       |   2        |
      Chemodectoma Benign                  |                                  X                                       |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +  +  +                                   +           +  +|  17        |
      Bilateral, Mesothelioma Malignant    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +  +           +                       +        +  +  +|  18        |
      Adenoma                              |                                  X                                       |          1 |
      Leukemia Mononuclear                 |                X                                                     X   |          4 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                +  +  +                                   +           +  +|  17        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X|         42 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Interstitial Cell, Adenoma           |                                                                      X   |          5 |
      Interstitial Cell, Carcinoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +                                   +           +  +|  16        |
      Femoral, Histiocytic Sarcoma         |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +  +  +                                   +           +  +|  19        |
      Inguinal, Leukemia Mononuclear       |                                                                          |          2 |
      Mandibular, Histiocytic Sarcoma      |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  75                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Leukemia Mononuclear     |          X     X                                                     X   |          9 |
      Mediastinal, Histiocytic Sarcoma     |                      X                                                   |          1 |
      Mediastinal, Leukemia Mononuclear    |                X                                                     X   |          5 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                                   +               |   4        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +     +  +  +     +  +  +           +        +  +        +  +  +|  29        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |          X     X           X  X  X                    X  X        X  X   |         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  M                                   +           +  M|  15        |
      Leukemia Mononuclear                 |                X                                                     X   |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +  +                          +     +                 +   |   8        |
      Fibroadenoma                         |                   X                          X     X                     |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +                                +     +     +  +|  20        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
      Subcutaneous Tissue, Fibroma         |                         X                                      X        X|          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +                                   +           +  +|  18        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +                                   +           +  +|  17        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +                                   +  +        +  +|  18        |
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |          1 |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                X                                                     X   |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +                                   +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +                                   +           +  +|  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                    +     +  +                          +         |   6        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  76                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5|            |
                                           | 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    240 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     1-1                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +     +  +  +                                   +  +  +     +  +|  21        |
      Leukemia Mononuclear                 |          X     X                                                     X   |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +                                   +           +  +|  15        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                      X                                                   |          1 |
      Leukemia Mononuclear                 |          X     X           X  X  X                    X  X        X  X  X|         22 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  77                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     M  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +              +  +        +        +  +  +        A        +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +              +  +        +        +  +  +        A        +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +              +  +        +        +  +  +        A        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                     X                                    |             
      Leukemia Mononuclear                 |    X  X                       X  X  X  X     X  X  X     X  X  X         |             
      Serosa, Mesothelioma Malignant       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +           +                     |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +              +  +        +     +  +  +  +        A        +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Mesothelioma Malignant               |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +              +  +        +        +  +  +        +        +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +              +  +        +  +     +  +  +        +        +|             
      Leukemia Mononuclear                 |    X                          X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Leukemia Mononuclear        |       X                                                                  |             
      Capsule, Mesothelioma Malignant      |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X                          X              X                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X                          X              X                           |             
      Pheochromocytoma Malignant           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                X     X           X           X        X  X        X  X  X|             
      Bilateral, Pheochromocytoma Benign   |                                           X                 X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +              +  +        +        +  +  +        A        +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +        +  +        +        +  +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      Pars Distalis, Adenoma               |       X           X        X                                             |             
      Pars Intermedia, Adenoma             |                                                                         X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +              +  +        +        +  +  +        A        +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abdominal, Mesothelioma Malignant    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +              +  +        +        +  +  +        +        +|             
      Mesothelioma Malignant               |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     M  +        +     +  +        +        +  +  +        +        +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |    X                          X        X           X                     |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +  +              +  +        +        +  +  +        +        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X     X  X|             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                        X           X                     |             
      Interstitial Cell, Adenoma           |                                  X                                X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +              +  +        +        +  +  +        A        +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +              +  +        +        +  +  +        +        +|             
      Deep Cervical, Leukemia Mononuclear  |    X                                                                     |             
      Mandibular, Leukemia Mononuclear     |    X                          X        X        X  X                     |             
      Mediastinal, Leukemia Mononuclear    |    X                          X        X                                 |             
      Mediastinal, Mesothelioma Malignant  |                                        X                                 |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +              +  +  +  +  +        +  +  +  +  +  +        +|             
      Leukemia Mononuclear                 |    X                       X  X  X  X  X        X  X     X  X  X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +              +  +        +        +  +  +        +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|             
                                           | 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X                          X        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +                 +                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +           +  +  +     +        +  +  +  +     +        +|             
      Basal Cell Adenoma                   |                                                          X               |             
      Keratoacanthoma                      |                X                                                         |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
      Subcutaneous Tissue, Fibrosarcoma    |          X  X                                                            |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +              +  +        +        +  +  +        +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +              +  +        +        +  +  +        +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +              +  +        +        +  +  +        +        +|             
      Leukemia Mononuclear                 |    X                          X        X        X  X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +              +  +        +        +  +  +        +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +              +  +        +  +     +  +  +        +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                            +                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
      Carcinoma                            |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +              +  +        +  +  +  +  +  +  +     +        +|             
      Leukemia Mononuclear                 |    X                       X  X        X     X  X  X     X               |             
      Capsule, Mesothelioma Malignant      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +              +  +        +        +  +  +        A        +|             
      Mesothelioma Malignant               |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                    X  X  X  X  X     X  X  X     X  X  X        X|             
      Mesothelioma Malignant               |                                        X           X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                               X                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X  X  X           X  X  X                 X  X     X            |         22 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   3        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +                    +  +     +  +     +  +        +  +  +   |  23        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   1        |
      Squamous Cell Papilloma              |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
      Leukemia Mononuclear                 |             X                                      X                     |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Leukemia Mononuclear        |                                                                          |          1 |
      Capsule, Mesothelioma Malignant      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X  X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X  X                                                         |          5 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |       X           X     X     X           X  X  X     X  X  X            |         19 |
      Bilateral, Pheochromocytoma Benign   |    X                             X                 X                 X  X|          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +  +                 +  +     +  +     +  +  +  +  +  +  +  +|  31        |
      Leukemia Mononuclear                 |             X  X                                                         |          3 |
      Pars Distalis, Adenoma               |                                                       X     X  X  X     X|          8 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | A        +  +                    +  +     +  +     +  +  +     +  +  +   |  22        |
      Bilateral, C-Cell, Adenoma           |                                                                   X      |          1 |
      C-Cell, Adenoma                      |          X                          X                    X     X         |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                          +               |   1        |
      Abdominal, Mesothelioma Malignant    |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Adenoma                              |                                           X              X               |          2 |
      Leukemia Mononuclear                 |          X  X                                      X                     |          7 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |  48        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X  X  X     X  X  X  X  X  X  X  X     X  X      |         43 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                                                          |          2 |
      Interstitial Cell, Adenoma           |                      X           X                                   X   |          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Femoral, Leukemia Mononuclear        |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +                 +  +     +  +     +  +  +     +  +  +   |  26        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     | X        X  X  X                 X                 X  X                  |         12 |
      Mediastinal, Leukemia Mononuclear    | X           X                    X                 X                     |          7 |
      Mediastinal, Mesothelioma Malignant  |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                           +  +                           |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                             +        +  +                           |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +  +              +  +  +     +  +     +  +  +  +  +  +  +   |  31        |
      Leukemia Mononuclear                 | X        X  X  X              X  X                 X  X     X            |         21 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +  +                    +  +     +  +     +  +  +     M  +  +   |  23        |
      Leukemia Mononuclear                 |          X  X                                      X                     |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +                                +        +           +      |   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +     +     +  +     +  +     +  +     +  +  +     +  +  +   |  31        |
      Basal Cell Adenoma                   |                                              X                           |          2 |
      Keratoacanthoma                      |                   X                          X                           |          3 |
      Squamous Cell Papilloma              |                         X  X                                             |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                      X   |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
      Leukemia Mononuclear                 | X        X  X                    X                 X  X                  |         11 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  24        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  25        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                       +|   4        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  83                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4|            |
                                           | 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +                    +  +     +  +  +  +  +  +     +  +  +   |  28        |
      Leukemia Mononuclear                 | X        X  X                    X                 X                     |         13 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +                    +  +     +  +     +  +  +     +  +  +   |  23        |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X        X  X  X           X  X  X                 X  X     X            |         24 |
      Mesothelioma Malignant               |                                                          X               |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  84                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X        X  X        X  X     X              X            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +           +                          +               |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  A     +  +     +           +     +     +        +  +  A  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +              +                  |             
      Squamous Cell Papilloma              |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Leukemia Mononuclear                 |                         X           X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Capsule, Leukemia Mononuclear        |                                                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Leukemia Mononuclear                 |       X                             X  X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Leukemia Mononuclear                 |       X                             X  X                                 |             
      Pheochromocytoma Malignant           |                            X                                             |             
      Pheochromocytoma Benign              |       X                             X                                    |             
      Bilateral, Pheochromocytoma Benign   |          X                                X        X                 X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |          X              X                       X                       X|             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  M     +  +     +  +  +     +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                     X                                    |             
      C-Cell, Carcinoma                    |                            X  X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +     +  +     +           +     +     +        M  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +     +  +     +           +     +  +  +     +  +  +  +  +     +|             
      Adenoma                              |                                              X                           |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                   X     X           X                       X            |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                         X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X     X  X  X|             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                                          X               |             
      Interstitial Cell, Adenoma           |                                  X  X                          X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Femoral, Histiocytic Sarcoma         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  M     +  +     +           +     +     +        +  +  A  +     +|             
      Inguinal, Leukemia Mononuclear       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Histiocytic Sarcoma      |                                                                          |             
      Mandibular, Leukemia Mononuclear     |       X        X  X     X           X                       X            |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |       X           X     X           X                       X            |             
      Pancreatic, Leukemia Mononuclear     |                                                             X            |             
      Renal, Leukemia Mononuclear          |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +        +        +                                +               |             
      Leukemia Mononuclear                 |       X        X        X                                                |             
      Mediastinal, Mesothelioma Malignant, |                                                                          |             
           Metastatic, Mesentery           |                                                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +     +           +  +  +  +  +        +  +  A  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X        X           X  X     X              X        X   |             
      Capsule, Mesothelioma Malignant      |                                                          X               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X     X           X                       X            |             
      Thymoma Benign                       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           +  +                 +           +           +           +|             
      Fibroadenoma                         |                                                                          |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Keratoacanthoma                      |                                           X                              |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Osteosarcoma                         |                                                                          |             
      Vertebra, Osteosarcoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Abdominal, Leukemia Mononuclear      |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +     +  +     +           +     +  +  +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|             
                             DAY ON TEST   | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|             
                                           | 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X  X     X           X        X              X            |             
      Osteosarcoma, Metastatic             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +  +     +           +     +     +        +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
      Adenoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +     +     +     +     +     +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |       X        X  X     X           X                       X            |             
      Transitional Epithelium, Carcinoma   |                                                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  A     +  +     +           +     +     +        +  +  A  +     +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X        X  X     X  X        X  X     X              X        X   |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                      X                                   X               |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Adenoma               |       X                                                                  |          1 |
      Hepatocellular Adenoma, Multiple     |                                                                         X|          1 |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X  X        X     X  X                 X           X  X     X  X  X  X|         20 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +                                   +               |   7        |
      Leukemia Mononuclear                 |    X                 X                                   X               |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +              +  +  +  A        +  +  +  +  +     +  +        +  +   |  26        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  89                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Leukemia Mononuclear                 |                                                          X        X      |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Leukemia Mononuclear        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  47        |
      Leukemia Mononuclear                 |    X           X     X                                X  X        X      |          9 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |    X           X     X                                X  X        X      |          9 |
      Pheochromocytoma Malignant           |                                           X                              |          2 |
      Pheochromocytoma Benign              |       X           X                                                      |          4 |
      Bilateral, Pheochromocytoma Benign   |                      X                                         X        X|          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +        +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Carcinoma                            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +              +  +  +  +        +  +  +  +  +     +  M        +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +              +  +  +  +     +  +  +  +  +  +     +  +  +     +  +   |  30        |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
      Pars Distalis, Adenoma               | X                                X  X  X              X     X            |         10 |
      Pars Distalis, Leukemia Mononuclear  |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +              +  +  +  A        +  +  +  +  +     +  +        +  A   |  27        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      C-Cell, Adenoma                      |                         X              X              X  X               |          5 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +        +     +  +  +  +        +  +  +  +  +     +  +     +  +  +   |  33        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                X         |          1 |
      Leukemia Mononuclear                 |    X                 X                                   X        X  X   |          9 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Leukemia Mononuclear                 |                                                          X               |          3 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  90                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X     X  X  X  X  X     X  X  X  X  X  X  X  X           X|         42 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Interstitial Cell, Adenoma           |                   X                 X                          X  X  X   |          8 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Femoral, Histiocytic Sarcoma         |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +              +  +  +  +     +  +  +  +  +  +     +  +     +  +  +   |  29        |
      Inguinal, Leukemia Mononuclear       |                                                                   X      |          2 |
      Mandibular, Histiocytic Sarcoma      |                                                 X                        |          1 |
      Mandibular, Leukemia Mononuclear     |    X                 X  X                 X           X  X        X  X   |         14 |
      Mediastinal, Histiocytic Sarcoma     |                                                 X                        |          1 |
      Mediastinal, Leukemia Mononuclear    |    X                 X  X                 X              X     X  X  X   |         13 |
      Pancreatic, Leukemia Mononuclear     |                                                          X               |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +  +                          +        +               |   8        |
      Leukemia Mononuclear                 |                      X                                   X               |          5 |
      Mediastinal, Mesothelioma Malignant, |                                                                          |            |
           Metastatic, Mesentery           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +  +        +  +  +  +  +     +  +     +  +  +   |  35        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X  X        X     X  X                 X           X  X     X  X  X   |         19 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  28        |
      Leukemia Mononuclear                 |    X                 X                    X              X        X      |          9 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                   +  +        +  +  +  +               |  14        |
      Fibroadenoma                         |                                                    X                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  91                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Osteosarcoma                         |                            X                                             |          1 |
      Vertebra, Osteosarcoma               |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Leukemia Mononuclear      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
      Leukemia Mononuclear                 |    X                 X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                               +                                          |   1        |
      Schwannoma Malignant                 |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  30        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X                 X  X                 X           X  X        X  X   |         15 |
      Osteosarcoma, Metastatic             |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  29        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +  +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  31        |
      Leukemia Mononuclear                 |    X                 X  X                 X              X        X      |         12 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +              +  +  +  +        +  +  +  +  +     +  +        +  +   |  27        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                 X                        |          1 |
      Leukemia Mononuclear                 |    X  X        X     X  X                 X           X  X     X  X  X  X|         22 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  92                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4|            |
                                           | 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
       3-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  93                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +  A  +        +  +        +     A  +  +  +     +  +  +     +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +  +  +|             
      Peyer's Patch, Leukemia Mononuclear  |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +  A  +        +  +        +     A  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X                          X                                X  X  X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Mesothelioma Malignant               |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                X  X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X            |             
      Pheochromocytoma Malignant           |                                           X  X                           |             
      Pheochromocytoma Benign              |       X        X  X     X  X     X  X  X                 X  X     X  X   |             
      Bilateral, Pheochromocytoma Benign   |                      X                                X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
      Adenoma                              |                            X                                             |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  A  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  A  A  +        +  +        +     A  +  +  +     +  +  +     +|             
      Bilateral, C-Cell, Adenoma           |                               X                                          |             
      C-Cell, Adenoma                      |                                                 X              X         |             
      C-Cell, Carcinoma                    |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               | X                                      X                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Carcinoma                            |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X|             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |                                        X                                 |             
      Interstitial Cell, Adenoma           |                                        X                                 |             
      Tunic, Mesothelioma Malignant        | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  A  +        +  +        +        +  +  +  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |                            X                                X     X      |             
      Mediastinal, Leukemia Mononuclear    |                            X                                X     X      |             
      Pancreatic, Leukemia Mononuclear     |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +                                      +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Hemangiosarcoma                      |                                                    X                     |             
      Leukemia Mononuclear                 | X                          X                                X  X  X      |             
      Sarcoma                              |                                                                          |             
      Capsule, Mesothelioma Malignant      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  +  +        +  +        +     +  M  +  +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|             
                                           | 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    800 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +                    +                 +                           |             
      Fibroadenoma                         |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                            X                                X  X  X      |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +        +               |             
      Pinna, Basosquamous Tumor Benign     |                                                          X               |             
      Pinna, Fibrosarcoma                  |                                                 X                        |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                  +               |             
      Squamous Cell Carcinoma              |                                                          X               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +        +  +        +     +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X     X      |             
      Transitional Epithelium, Carcinoma   |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  M  A  +        +  +        +     +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                          X                                X  X  X      |             
      Mesothelioma Malignant               | X                                      X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +  +  +  +              +     +        +     +     +  +      |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  21        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  22        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A  +     +  +  +  A           A  +     A        +     +     +  +      |  23        |
      Peyer's Patch, Leukemia Mononuclear  |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A  +        +  +  A           A  +     A        +     +     +  +      |  22        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Adenoma               |                                                             X            |          1 |
      Leukemia Mononuclear                 |                X  X                                               X  X   |          9 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   2        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  28        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    A  +     +  +  +  +           A  +     +        +     +     +  +      |  26        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    A  +     +  +  +  +           A  +     +        +     +     +  +      |  26        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    A  +     A  +  +  A           A  +     A        +     +     +  +      |  23        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Leukemia Mononuclear                 |                X  X                                               X      |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                                               X      |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                                               X      |          4 |
      Pheochromocytoma Malignant           |       X        X                                                         |          4 |
      Pheochromocytoma Benign              |                X                    X        X                    X      |         16 |
      Bilateral, Pheochromocytoma Benign   |                               X                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  97                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  25        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    M  +     +  +  +  +           +  +     +        +     +     M  +     +|  27        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
      Pars Distalis, Adenoma               |             X                                      X     X              X|          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    A  +     +  +  +  A              +     +        +     +     +  +      |  23        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                           X        X     X               |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  30        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
      Mesothelioma Malignant               |                                  X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                X  X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X  X        X  X  X  X  X     X     X        X  X|         41 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                  X                                       |          2 |
      Interstitial Cell, Adenoma           |                               X                    X     X        X      |          5 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Mandibular, Leukemia Mononuclear     |                X  X                                                      |          5 |
      Mediastinal, Leukemia Mononuclear    |                X  X                                                      |          5 |
      Pancreatic, Leukemia Mononuclear     |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                      +               |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  98                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    A  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                X  X                                               X      |          8 |
      Sarcoma                              |                                  X                                       |          1 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +     +  +  +  +              +     M        +     M     +  +      |  25        |
      Leukemia Mononuclear                 |                X  X                                                      |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +     +                                +     +               |   7        |
      Fibroadenoma                         |                                                          X               |          1 |
      Sarcoma                              |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +  +  +  +           +  +     +        +  +  +     +  +      |  30        |
      Keratoacanthoma                      |                                                    X                     |          1 |
      Squamous Cell Carcinoma              |                                                       X                  |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +  +  +           +  +     +        +     +     +  +      |  27        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
      Alveolar/Bronchiolar Adenoma         |                                           X                              |          1 |
      Leukemia Mononuclear                 |                X  X                                               X      |          7 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +  +  +  +           +  +     +        +     +     +  +      |  29        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +     +  +     +           +  +     +        +     +     +  +      |  28        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                                             |   3        |
      Pinna, Basosquamous Tumor Benign     |                                                                          |          1 |
      Pinna, Fibrosarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                          +                       +     +            |   6        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  99                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4|            |
                                           | 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    800 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                    +                                    |   2        |
      Carcinoma                            |                X                    X                                    |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    A  +     +  +  +  +           +  +     +        +     +     +  +      |  30        |
      Leukemia Mononuclear                 |                X  X                                               X      |          6 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    A  +     +  +  +  A           A  +     +        +     +     +  +      |  24        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                X  X                                               X  X   |          9 |
      Mesothelioma Malignant               |                                  X                                       |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 100                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|             
                                           | 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                        X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                              X                           |             
      Hepatocellular Adenoma, Multiple     |                                                    X                     |             
      Leukemia Mononuclear                 | X  X  X                                            X        X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                      +            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                        X            |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
      Molar, Adamantinoma Benign           |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic                |                   X                                                      |             
      Leukemia Mononuclear                 |       X                                                     X            |             
      Ventricle Left, Schwannoma Benign    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Capsule, Leukemia Mononuclear        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|             
                                           | 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                   X                                                      |             
      Leukemia Mononuclear                 | X                                                           X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 | X                                                           X            |             
      Pheochromocytoma Benign              |    X  X  X     X  X           X        X     X                 X  X     X|             
      Bilateral, Pheochromocytoma Benign   |                         X        X                       X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                X     X        X                    X           X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                     X            |             
      C-Cell, Adenoma                      |       X                          X                 X     X     X         |             
      C-Cell, Carcinoma                    |                   X                                                      |             
      Follicular Cell, Adenocarcinoma      |                                                                          |             
      Follicular Cell, Adenoma             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                     X            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                                                     X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X  X  X  X  X  X     X  X  X  X  X     X  X  X  X|             
      Interstitial Cell, Adenoma           |                                                             X            |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deep Cervical, Leukemia Mononuclear  |       X                                                                  |             
      Deep Cervical, Mediastinal,          |                                                                          |             
          Mandibular, Carcinoma,           |                                                                          |             
          Metastatic, Thyroid Gland        |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|             
                                           | 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                             X            |             
      Mandibular, Carcinoma, Metastatic,   |                                                                          |             
           Skin                            |                                                                          |             
      Mandibular, Leukemia Mononuclear     | X  X  X                                                     X            |             
      Mediastinal, Leukemia Mononuclear    |    X  X                                            X        X            |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +           +     +                                   +            |             
      Leukemia Mononuclear                 |    X  X                                                     X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                                            X        X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  M  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +  M|             
      Leukemia Mononuclear                 | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +           +  +  +     +                                   +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |    X                                                        X            |             
      Squamous Cell Carcinoma              |                                                          X               |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Left, Femur, Osteosarcoma            |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
      Abdominal, Leukemia Mononuclear      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                   X                                                      |             
      Leukemia Mononuclear                 | X  X  X                                            X        X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lamina Propria, Carcinoma,           |                                                                          |             
          Metastatic, Thyroid Gland        |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|             
                                           | 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2400 PPM                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                             +                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +     +           +                        |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                                                     X            |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                                            X        X            |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3|            |
                                           | 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  47        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  A|  46        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  47        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  48        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  47        |
      Leukemia Mononuclear                 |                                                       X                  |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  48        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                   X                                         X            |          3 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |          X        X     X     X     X  X     X  X  X  X  X        X  X  X|         19 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +  +     +     +      |   6        |
      Leukemia Mononuclear                 |                                                    X  X           X      |          4 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A|  48        |
      Leukemia Mononuclear                 |          X              X                          X                     |          5 |
      Mesothelioma Malignant               |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Leukemia Mononuclear                 |                                                 X     X                  |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Leukemia Mononuclear                 |                                                       X           X      |          4 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Molar, Adamantinoma Benign           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Leukemia Mononuclear                 |          X        X     X     X                 X  X  X  X        X  X  X|         13 |
      Ventricle Left, Schwannoma Benign    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 105                                                               
NTP Experiment-Test: 05075-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         DIPHENYLHYDANTOIN                                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 06:58:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3|            |
                                           | 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    2400 PPM                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Leukemia Mononuclear        |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |          X        X     X           X              X              X      |          8 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |          X        X                 X              X  X           X      |          8 |
      Pheochromocytoma Benign              |                X  X                       X                       X  X   |         16 |
      Bilateral, Pheochromocytoma Benign   |    X  X                             X              X  X     X            |          9 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |    X                       X                 X                    X  X   |         10 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|  48        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      C-Cell, Adenoma                      |                X                       X              X     X     X      |         10 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenocarcinoma      |                                                             X            |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
      Carcinoma                            |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
      Bilateral, Mesothelioma Malignant    |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  +  +  +  +  +  +