TDMS Study 05075-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIPHENYLHYDANTOIN DATE: 09/09/94
EXPERIMENT: 05075 TEST: 01 TIME: 09:34:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 55765
PATHOLOGIST: M. RYAN S. EUSTIS CAS: 57-41-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIPHENYLHYDANTOIN DATE: 09/09/94
EXPERIMENT: 05075 TEST: 01 TIME: 09:34:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 55765
PATHOLOGIST: M. RYAN S. EUSTIS CAS: 57-41-0
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIPHENYLHYDANTOIN DATE: 09/09/94
EXPERIMENT: 05075 TEST: 01 TIME: 09:34:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 55765
PATHOLOGIST: M. RYAN S. EUSTIS CAS: 57-41-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DIPHENYLHYDANTOIN
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Adenoma
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Carcinoma or Adenoma
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma
Mammary Gland Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Testes Adenoma
Thyroid Gland: C-Cell Carcinoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus DIPHENYLHYDANTOIN DATE: 09/09/94
EXPERIMENT: 05075 TEST: 01 TIME: 09:34:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 55765
PATHOLOGIST: M. RYAN S. EUSTIS CAS: 57-41-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DIPHENYLHYDANTOIN
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Mammary Gland Carcinoma
Carcinoma or Adenoma
Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/48 (0%) 0/145 (0%) 3/99 (3%) | 2/71 (3%) 0/23 (0%) 0/50 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 5.2% | 6.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/32 (0%) 0/70 (0%) 1/52 (2%) | 2/32 (6%) 0/0 0/0 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 697 | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.012 * (e) (e) P=0.137 | P=0.057N (e) (e) P=0.093N |
|INCIDENTAL TUMOR | P=0.009 ** (e) (e) P=0.108 | P=0.057N (e) (e) P=0.093N |
|LOGISTIC REGRESSION | P=0.010 * (e) (e) P=0.124 | P=0.057N (e) (e) P=0.093N |
|COCHRAN-ARMITAGE | P=0.011 * | P=0.152N |
|FISHER EXACT | (e) (e) P=0.121 | P=0.569N P=0.342N P=0.171N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 31/100 (31%) 16/50 (32%) 56/146 (38%) 52/98 (53%) | 5/70 (7%) 0/23 (0%) 2/52 (4%) 5/100 (5%) |
|ADJUSTED (b) | 47.7% 43.9% 56.7% 69.5% | 12.1% 0.0% 50.4% 6.9% |
|TERMINAL (d) | 18/50 (36%) 13/33 (39%) 32/71 (45%) 30/52 (58%) | 3/31 (10%) 0/0 1/2 (50%) 3/69 (4%) |
|FIRST INCIDENCE (DAYS) | 627 549 501 494 | 627 --- 648 671 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.281N P=0.164 P=0.009 ** | P=0.300N P=0.413N P=0.678N P=0.317N |
|INCIDENTAL TUMOR | P<0.001 ** P=0.574N P=0.144 P<0.001 ** | P=0.396N P=0.326N P=0.673 P=0.444N |
|LOGISTIC REGRESSION | P<0.001 ** P=0.501N P=0.155 P<0.001 ** | P=0.344N P=0.316N P=0.606N P=0.330N |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.538N |
|FISHER EXACT | P=0.522 P=0.147 P=0.001 ** | P=0.233N P=0.359N P=0.394N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 2/50 (4%) 7/146 (5%) 3/98 (3%) | 1/70 (1%) 0/23 (0%) 0/52 (0%) 0/100 (0%) |
|ADJUSTED (b) | 1.2% 4.3% 7.2% 4.6% | 3.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 2/71 (3%) 1/52 (2%) | 1/31 (3%) 0/0 0/2 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 632 340 307 399 | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.450 P=0.273 P=0.109 P=0.320 | P=0.224N (e) P=0.967N P=0.341N |
|INCIDENTAL TUMOR | P=0.430 P=0.601 P=0.148 P=0.297 | P=0.224N (e) P=0.967N P=0.341N |
|LOGISTIC REGRESSION | P=0.529 P=0.413 P=0.111 P=0.345 | P=0.224N (e) P=0.967N P=0.341N |
|COCHRAN-ARMITAGE | P=0.442 | P=0.362N |
|FISHER EXACT | P=0.258 P=0.096 P=0.303 | P=0.753N P=0.574N P=0.412N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 32/100 (32%) 18/50 (36%) 62/146 (42%) 54/98 (55%) | 6/70 (9%) 0/23 (0%) 2/52 (4%) 5/100 (5%) |
|ADJUSTED (b) | 48.4% 46.3% 60.5% 71.1% | 15.2% 0.0% 50.4% 6.9% |
|TERMINAL (d) | 18/50 (36%) 13/33 (39%) 34/71 (48%) 31/52 (60%) | 4/31 (13%) 0/0 1/2 (50%) 3/69 (4%) |
|FIRST INCIDENCE (DAYS) | 627 340 307 399 | 627 --- 648 671 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.409N P=0.084 P=0.007 ** | P=0.170N P=0.413N P=0.652N P=0.183N |
|INCIDENTAL TUMOR | P<0.001 ** P=0.528 P=0.076 P<0.001 ** | P=0.237N P=0.326N P=0.692 P=0.278N |
|LOGISTIC REGRESSION | P<0.001 ** P=0.427 P=0.065 P<0.001 ** | P=0.216N P=0.287N P=0.536N P=0.199N |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.411N |
|FISHER EXACT | P=0.377 P=0.063 P<0.001 ** | P=0.172N P=0.255N P=0.267N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 1/100 (1%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.8% 1.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 652 609 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.392 (e) P=0.339 P=0.495 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.378 (e) P=0.355 P=0.485 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.416 (e) P=0.338 P=0.537 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.397 | (e) |
|FISHER EXACT | (e) P=0.359 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/77 (3%) 0/17 (0%) 0/82 (0%) 1/100 (1%) | 0/71 (0%) 0/23 (0%) 0/52 (0%) 0/100 (0%) |
|ADJUSTED (b) | 3.2% 0.0% 0.0% 1.7% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/0 0/3 (0%) 0/53 (0%) | 0/31 (0%) 0/0 0/1 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 662 --- --- 715 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.601N P=0.359N P=0.160N P=0.483N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.622N P=0.547N P=0.136N P=0.552N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.401N P=0.678N P=0.265N P=0.388N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.462N | (e) |
|FISHER EXACT | P=0.669N P=0.233N P=0.403N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/76 (4%) 1/18 (6%) 3/86 (3%) 2/99 (2%) | 4/66 (6%) 4/24 (17%) 6/58 (10%) 1/99 (1%) |
|ADJUSTED (b) | 6.6% 50.0% 14.2% 3.8% | 12.9% 100.0% 31.5% 1.5% |
|TERMINAL (d) | 1/26 (4%) 1/2 (50%) 1/8 (13%) 2/53 (4%) | 4/31 (13%) 1/1 (100%) 3/10 (30%) 1/68 (1%) |
|FIRST INCIDENCE (DAYS) | 613 732 (T) 626 732 (T) | 729 (T) 634 439 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.159N P=0.682 P=0.632 P=0.311N | P=0.003N** P=0.004 ** P=0.071 P=0.028N* |
|INCIDENTAL TUMOR | P=0.167N P=0.595 P=0.636 P=0.341N | P=0.004N** P=0.019 * P=0.063 P=0.028N* |
|LOGISTIC REGRESSION | P=0.192N P=0.568 P=0.654N P=0.347N | P=0.012N* P=0.030 * P=0.270 P=0.028N* |
|COCHRAN-ARMITAGE | P=0.273N | P=0.014N* |
|FISHER EXACT | P=0.579 P=0.599N P=0.377N | P=0.128 P=0.293 P=0.084N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/76 (4%) 0/18 (0%) 2/86 (2%) 0/99 (0%) | 2/66 (3%) 0/24 (0%) 1/58 (2%) 2/99 (2%) |
|ADJUSTED (b) | 6.3% 0.0% 13.2% 0.0% | 4.7% 0.0% 10.0% 2.8% |
|TERMINAL (d) | 1/26 (4%) 0/2 (0%) 1/8 (13%) 0/53 (0%) | 1/31 (3%) 0/1 (0%) 1/10 (10%) 1/68 (1%) |
|FIRST INCIDENCE (DAYS) | 634 --- 623 --- | 700 --- 729 (T) 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.063N P=0.361N P=0.587N P=0.085N | P=0.463N P=0.624N P=0.696N P=0.533N |
|INCIDENTAL TUMOR | P=0.065N P=0.441N P=0.588N P=0.098N | P=0.541N P=0.597N P=0.724N P=0.663N |
|LOGISTIC REGRESSION | P=0.071N P=0.481N P=0.473N P=0.080N | P=0.434N P=0.669N P=0.729 P=0.498N |
|COCHRAN-ARMITAGE | P=0.077N | P=0.592N |
|FISHER EXACT | P=0.524N P=0.442N P=0.080N | P=0.536N P=0.549N P=0.526N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/76 (8%) 1/18 (6%) 5/86 (6%) 2/99 (2%) | 6/66 (9%) 4/24 (17%) 7/58 (12%) 3/99 (3%) |
|ADJUSTED (b) | 12.6% 50.0% 27.1% 3.8% | 17.4% 100.0% 41.2% 4.2% |
|TERMINAL (d) | 2/26 (8%) 1/2 (50%) 2/8 (25%) 2/53 (4%) | 5/31 (16%) 1/1 (100%) 4/10 (40%) 2/68 (3%) |
|FIRST INCIDENCE (DAYS) | 613 732 (T) 623 732 (T) | 700 634 439 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.026N* P=0.455N P=0.589N P=0.053N | P=0.004N** P=0.023 * P=0.108 P=0.044N* |
|INCIDENTAL TUMOR | P=0.027N* P=0.595N P=0.589N P=0.066N | P=0.006N** P=0.070 P=0.091 P=0.067N |
|LOGISTIC REGRESSION | P=0.037N* P=0.647N P=0.473N P=0.062N | P=0.016N* P=0.075 P=0.334 P=0.046N* |
|COCHRAN-ARMITAGE | P=0.058N | P=0.023N* |
|FISHER EXACT | P=0.598N P=0.414N P=0.070N | P=0.255 P=0.401 P=0.093N |
|=================================================================================================================================|
| |
|Ear |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 1.9% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 1/99 (1%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 699 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.634N (e) P=0.352 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.712N (e) P=0.310 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.658N (e) P=0.340 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.664N |
|FISHER EXACT | (e) (e) (e) | (e) P=0.359 (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/77 (5%) 0/15 (0%) 1/76 (1%) 0/97 (0%) | 2/70 (3%) 1/23 (4%) 1/48 (2%) 0/100 (0%) |
|ADJUSTED (b) | 9.9% 0.0% 0.9% 0.0% | 4.4% 0.0% 1.0% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/0 0/3 (0%) 0/52 (0%) | 1/31 (3%) 0/0 0/1 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 543 --- 652 --- | 652 681 711 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027N* P=0.382N P=0.293N P=0.030N* | P=0.083N P=0.588 P=0.635N P=0.156N |
|INCIDENTAL TUMOR | P=0.025N* P=0.755N P=0.345N P=0.033N* | P=0.130N P=0.600 P=0.711N P=0.206N |
|LOGISTIC REGRESSION | P=0.036N* P=0.438N P=0.199N P=0.039N* | P=0.064N P=0.581 P=0.717 P=0.156N |
|COCHRAN-ARMITAGE | P=0.038N* | P=0.087N |
|FISHER EXACT | P=0.484N P=0.187N P=0.037N* | P=0.578 P=0.639N P=0.168N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/77 (1%) 0/15 (0%) 2/76 (3%) 0/97 (0%) | 0/70 (0%) 0/23 (0%) 0/48 (0%) 0/100 (0%) |
|ADJUSTED (b) | 3.7% 0.0% 33.8% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/0 1/3 (33%) 0/52 (0%) | 0/31 (0%) 0/0 0/1 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 732 (T) --- 517 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.188N (e) P=0.136 P=0.369N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.172N (e) P=0.098 P=0.369N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.292N (e) P=0.491 P=0.369N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.291N | (e) |
|FISHER EXACT | P=0.837N P=0.495 P=0.443N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/77 (6%) 0/15 (0%) 3/76 (4%) 0/97 (0%) | 2/70 (3%) 1/23 (4%) 1/48 (2%) 0/100 (0%) |
|ADJUSTED (b) | 13.5% 0.0% 34.4% 0.0% | 4.4% 0.0% 1.0% 0.0% |
|TERMINAL (d) | 3/27 (11%) 0/0 1/3 (33%) 0/52 (0%) | 1/31 (3%) 0/0 0/1 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 543 --- 517 --- | 652 681 711 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.010N** P=0.382N P=0.607 P=0.011N* | P=0.083N P=0.588 P=0.635N P=0.156N |
|INCIDENTAL TUMOR | P=0.008N** P=0.755N P=0.514 P=0.012N* | P=0.130N P=0.600 P=0.711N P=0.206N |
|LOGISTIC REGRESSION | P=0.020N* P=0.395N P=0.384N P=0.017N* | P=0.064N P=0.581 P=0.717 P=0.156N |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.087N |
|FISHER EXACT | P=0.402N P=0.367N P=0.016N* | P=0.578 P=0.639N P=0.168N |
|=================================================================================================================================|
| |
|Kidney: Pelvis and Transitional Epithelium |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/78 (0%) 0/21 (0%) 2/89 (2%) 0/100 (0%) | 0/71 (0%) 0/23 (0%) 0/52 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.5% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/28 (0%) 0/4 (0%) 0/11 (0%) 0/53 (0%) | 0/31 (0%) 0/0 0/2 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 487 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.671N (e) P=0.333 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.612N (e) P=0.295 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.560N (e) P=0.350 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.558N | (e) |
|FISHER EXACT | (e) P=0.283 (e) | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 2/49 (4%) 4/148 (3%) 9/99 (9%) | 0/99 (0%) 0/50 (0%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 1.4% 5.7% 5.6% 15.4% | 0.0% 0.0% 2.0% 1.4% |
|TERMINAL (d) | 0/50 (0%) 1/33 (3%) 4/71 (6%) 5/53 (9%) | 0/60 (0%) 0/27 (0%) 2/99 (2%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 662 683 732 (T) 695 | --- --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004 ** P=0.327 P=0.308 P=0.017 * | P=0.439 (e) P=0.355 P=0.528 |
|INCIDENTAL TUMOR | P=0.003 ** P=0.187 P=0.313 P=0.009 ** | P=0.439 (e) P=0.355 P=0.528 |
|LOGISTIC REGRESSION | P=0.003 ** P=0.264 P=0.325 P=0.012 * | P=0.439 (e) P=0.355 P=0.528 |
|COCHRAN-ARMITAGE | P=0.003 ** | P=0.398 |
|FISHER EXACT | P=0.252 P=0.329 P=0.009 ** | (e) P=0.362 P=0.503 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 3/49 (6%) 5/148 (3%) 9/99 (9%) | 0/99 (0%) 0/50 (0%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 1.4% 8.4% 7.0% 15.4% | 0.0% 0.0% 2.0% 1.4% |
|TERMINAL (d) | 0/50 (0%) 1/33 (3%) 5/71 (7%) 5/53 (9%) | 0/60 (0%) 0/27 (0%) 2/99 (2%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 662 683 732 (T) 695 | --- --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.011 * P=0.159 P=0.210 P=0.017 * | P=0.439 (e) P=0.355 P=0.528 |
|INCIDENTAL TUMOR | P=0.008 ** P=0.043 * P=0.213 P=0.009 ** | P=0.439 (e) P=0.355 P=0.528 |
|LOGISTIC REGRESSION | P=0.009 ** P=0.107 P=0.226 P=0.012 * | P=0.439 (e) P=0.355 P=0.528 |
|COCHRAN-ARMITAGE | P=0.010 ** | P=0.398 |
|FISHER EXACT | P=0.104 P=0.225 P=0.009 ** | (e) P=0.362 P=0.503 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 3/49 (6%) 5/148 (3%) 9/99 (9%) | 0/99 (0%) 0/50 (0%) 2/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 1.4% 8.4% 7.0% 15.4% | 0.0% 0.0% 2.0% 1.4% |
|TERMINAL (d) | 0/50 (0%) 1/33 (3%) 5/71 (7%) 5/53 (9%) | 0/60 (0%) 0/27 (0%) 2/99 (2%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 662 683 732 (T) 695 | --- --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.011 * P=0.159 P=0.210 P=0.017 * | P=0.439 (e) P=0.355 P=0.528 |
|INCIDENTAL TUMOR | P=0.008 ** P=0.043 * P=0.213 P=0.009 ** | P=0.439 (e) P=0.355 P=0.528 |
|LOGISTIC REGRESSION | P=0.009 ** P=0.107 P=0.226 P=0.012 * | P=0.439 (e) P=0.355 P=0.528 |
|COCHRAN-ARMITAGE | P=0.010 ** | P=0.398 |
|FISHER EXACT | P=0.104 P=0.225 P=0.009 ** | (e) P=0.362 P=0.503 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/77 (3%) 0/18 (0%) 1/83 (1%) 2/100 (2%) | 1/72 (1%) 0/24 (0%) 0/54 (0%) 1/100 (1%) |
|ADJUSTED (b) | 5.4% 0.0% 1.1% 3.4% | 3.1% 0.0% 0.0% 1.4% |
|TERMINAL (d) | 1/27 (4%) 0/1 (0%) 0/4 (0%) 1/53 (2%) | 1/32 (3%) 0/1 (0%) 0/3 (0%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 715 --- 694 695 | 729 (T) --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.590N P=0.561N P=0.587N P=0.556N | P=0.499N P=0.997N P=0.931N P=0.581N |
|INCIDENTAL TUMOR | P=0.607N P=0.709N P=0.565N P=0.602N | P=0.499N P=0.997N P=0.931N P=0.581N |
|LOGISTIC REGRESSION | P=0.490N P=0.788N P=0.656N P=0.517N | P=0.499N P=0.997N P=0.931N P=0.581N |
|COCHRAN-ARMITAGE | P=0.638 | P=0.684 |
|FISHER EXACT | P=0.655N P=0.472N P=0.586N | P=0.750N P=0.571N P=0.663N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/77 (1%) 1/18 (6%) 0/83 (0%) 4/100 (4%) | 1/72 (1%) 0/24 (0%) 1/54 (2%) 0/100 (0%) |
|ADJUSTED (b) | 3.7% 100.0% 0.0% 7.5% | 3.1% 0.0% 1.0% 0.0% |
|TERMINAL (d) | 1/27 (4%) 1/1 (100%) 0/4 (0%) 4/53 (8%) | 1/32 (3%) 0/1 (0%) 0/3 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 732 (T) 732 (T) --- 732 (T) | 729 (T) --- 704 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.527 P=0.048 * P=0.866N P=0.428 | P=0.248N P=0.997N P=0.644 P=0.347N |
|INCIDENTAL TUMOR | P=0.527 P=0.048 * P=0.866N P=0.428 | P=0.299N P=0.997N P=0.582 P=0.347N |
|LOGISTIC REGRESSION | P=0.527 P=0.048 * P=0.866N P=0.428 | P=0.220N P=0.997N P=0.476 P=0.347N |
|COCHRAN-ARMITAGE | P=0.170 | P=0.316N |
|FISHER EXACT | P=0.345 P=0.481N P=0.276 | P=0.750N P=0.675 P=0.419N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/77 (4%) 1/18 (6%) 1/83 (1%) 6/100 (6%) | 2/72 (3%) 0/24 (0%) 1/54 (2%) 1/100 (1%) |
|ADJUSTED (b) | 9.1% 100.0% 1.1% 10.8% | 6.3% 0.0% 1.0% 1.4% |
|TERMINAL (d) | 2/27 (7%) 1/1 (100%) 0/4 (0%) 5/53 (9%) | 2/32 (6%) 0/1 (0%) 0/3 (0%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 715 732 (T) 694 695 | 729 (T) --- 704 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.555 P=0.494 P=0.520N P=0.550 | P=0.200N P=0.967N P=0.681 P=0.245N |
|INCIDENTAL TUMOR | P=0.546 P=0.366 P=0.498N P=0.518 | P=0.230N P=0.967N P=0.627 P=0.245N |
|LOGISTIC REGRESSION | P=0.559 P=0.354 P=0.513N P=0.567 | P=0.196N P=0.967N P=0.566 P=0.245N |
|COCHRAN-ARMITAGE | P=0.237 | P=0.383N |
|FISHER EXACT | P=0.575 P=0.282N P=0.393 | P=0.561N P=0.607N P=0.378N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) | 2/100 (2%) 0/50 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.3% 0.0% 1.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 2/60 (3%) 0/27 (0%) 1/99 (1%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 729 (T) --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.196N P=0.426N P=0.330N P=0.209N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.196N P=0.426N P=0.330N P=0.209N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.196N P=0.426N P=0.330N P=0.209N |
|COCHRAN-ARMITAGE | (e) | P=0.223N |
|FISHER EXACT | (e) (e) (e) | P=0.443N P=0.351N P=0.249N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) | 6/100 (6%) 0/50 (0%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 2.0% 0.0% 0.0% 0.0% | 8.1% 0.0% 2.0% 0.0% |
|TERMINAL (d) | 1/50 (2%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 2/60 (3%) 0/27 (0%) 1/99 (1%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 732 (T) --- --- --- | 388 --- 711 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445N P=0.583N P=0.430N P=0.488N | P=0.020N* P=0.108N P=0.039N* P=0.017N* |
|INCIDENTAL TUMOR | P=0.445N P=0.583N P=0.430N P=0.488N | P=0.039N* P=0.102N P=0.068N P=0.043N* |
|LOGISTIC REGRESSION | P=0.445N P=0.583N P=0.430N P=0.488N | P=0.022N* P=0.099N P=0.050N P=0.017N* |
|COCHRAN-ARMITAGE | P=0.443N | P=0.024N* |
|FISHER EXACT | P=0.667N P=0.400N P=0.500N | P=0.083N P=0.047N* P=0.014N* |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) | 8/100 (8%) 0/50 (0%) 3/150 (2%) 0/100 (0%) |
|ADJUSTED (b) | 2.0% 0.0% 0.0% 0.0% | 11.3% 0.0% 3.0% 0.0% |
|TERMINAL (d) | 1/50 (2%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 4/60 (7%) 0/27 (0%) 2/99 (2%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 732 (T) --- --- --- | 388 --- 711 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445N P=0.583N P=0.430N P=0.488N | P=0.007N** P=0.060N P=0.020N* P=0.004N** |
|INCIDENTAL TUMOR | P=0.445N P=0.583N P=0.430N P=0.488N | P=0.013N* P=0.056N P=0.034N* P=0.012N* |
|LOGISTIC REGRESSION | P=0.445N P=0.583N P=0.430N P=0.488N | P=0.009N** P=0.049N* P=0.026N* P=0.006N** |
|COCHRAN-ARMITAGE | P=0.443N | P=0.009N** |
|FISHER EXACT | P=0.667N P=0.400N P=0.500N | P=0.035N* P=0.026N* P=0.003N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 4/50 (8%) 2/150 (1%) 1/100 (1%) | 26/100 (26%) 14/50 (28%) 18/150 (12%) 6/100 (6%) |
|ADJUSTED (b) | 6.4% 10.9% 2.1% 1.9% | 34.7% 41.2% 16.2% 8.0% |
|TERMINAL (d) | 2/50 (4%) 2/33 (6%) 1/71 (1%) 1/53 (2%) | 14/60 (23%) 8/27 (30%) 12/99 (12%) 3/69 (4%) |
|FIRST INCIDENCE (DAYS) | 617 654 597 732 (T) | 586 630 595 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.071N P=0.359 P=0.188N P=0.174N | P<0.001N** P=0.374 P=0.002N** P<0.001N** |
|INCIDENTAL TUMOR | P=0.071N P=0.233 P=0.181N P=0.187N | P<0.001N** P=0.533 P=0.003N** P<0.001N** |
|LOGISTIC REGRESSION | P=0.067N P=0.267 P=0.176N P=0.185N | P<0.001N** P=0.476 P=0.003N** P<0.001N** |
|COCHRAN-ARMITAGE | P=0.066N | P<0.001N** |
|FISHER EXACT | P=0.254 P=0.176N P=0.184N | P=0.470 P=0.004N** P<0.001N** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/100 (4%) 4/50 (8%) 2/150 (1%) 1/100 (1%) | 28/100 (28%) 14/50 (28%) 19/150 (13%) 6/100 (6%) |
|ADJUSTED (b) | 6.4% 10.9% 2.1% 1.9% | 37.5% 41.2% 17.2% 8.0% |
|TERMINAL (d) | 2/50 (4%) 2/33 (6%) 1/71 (1%) 1/53 (2%) | 16/60 (27%) 8/27 (30%) 13/99 (13%) 3/69 (4%) |
|FIRST INCIDENCE (DAYS) | 617 654 597 732 (T) | 586 630 595 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.071N P=0.359 P=0.188N P=0.174N | P<0.001N** P=0.463 P=0.001N** P<0.001N** |
|INCIDENTAL TUMOR | P=0.071N P=0.233 P=0.181N P=0.187N | P<0.001N** P=0.526N P=0.002N** P<0.001N** |
|LOGISTIC REGRESSION | P=0.067N P=0.267 P=0.176N P=0.185N | P<0.001N** P=0.577 P=0.002N** P<0.001N** |
|COCHRAN-ARMITAGE | P=0.066N | P<0.001N** |
|FISHER EXACT | P=0.254 P=0.176N P=0.184N | P=0.580N P=0.002N** P<0.001N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/100 (5%) 4/50 (8%) 2/150 (1%) 1/100 (1%) | 34/100 (34%) 14/50 (28%) 21/150 (14%) 6/100 (6%) |
|ADJUSTED (b) | 8.3% 10.9% 2.1% 1.9% | 43.4% 41.2% 19.0% 8.0% |
|TERMINAL (d) | 3/50 (6%) 2/33 (6%) 1/71 (1%) 1/53 (2%) | 18/60 (30%) 8/27 (30%) 14/99 (14%) 3/69 (4%) |
|FIRST INCIDENCE (DAYS) | 617 654 597 732 (T) | 388 630 595 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044N* P=0.474 P=0.101N P=0.100N | P<0.001N** P=0.413N P<0.001N** P<0.001N** |
|INCIDENTAL TUMOR | P=0.044N* P=0.348 P=0.096N P=0.107N | P<0.001N** P=0.256N P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION | P=0.042N* P=0.373 P=0.092N P=0.108N | P<0.001N** P=0.282N P<0.001N** P<0.001N** |
|COCHRAN-ARMITAGE | P=0.040N* | P<0.001N** |
|FISHER EXACT | P=0.347 P=0.093N P=0.106N | P=0.291N P<0.001N** P<0.001N** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 1/71 (1%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 704 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.662N (e) P=0.329 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.671N (e) P=0.337 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.665N (e) P=0.334 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.664N | (e) |
|FISHER EXACT | (e) P=0.359 (e) | (e) (e) (e) |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% 0.0% | 0.0% 0.0% 1.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 1/71 (1%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 1/99 (1%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 704 --- | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.662N (e) P=0.329 (e) | P=0.748N (e) P=0.600 (e) |
|INCIDENTAL TUMOR | P=0.671N (e) P=0.337 (e) | P=0.748N (e) P=0.600 (e) |
|LOGISTIC REGRESSION | P=0.665N (e) P=0.334 (e) | P=0.748N (e) P=0.600 (e) |
|COCHRAN-ARMITAGE | P=0.664N | P=0.770N |
|FISHER EXACT | (e) P=0.359 (e) | (e) P=0.600 (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/84 (29%) 6/20 (30%) 23/88 (26%) 19/97 (20%) | 51/91 (56%) 15/43 (35%) 47/100 (47%) 26/100 (26%)|
|ADJUSTED (b) | 49.1% 76.9% 71.4% 28.6% | 65.9% 56.3% 64.1% 33.4% |
|TERMINAL (d) | 14/34 (41%) 3/4 (75%) 8/12 (67%) 10/53 (19%) | 27/51 (53%) 10/20 (50%) 30/51 (59%) 19/69 (28%) |
|FIRST INCIDENCE (DAYS) | 519 617 518 568 | 470 425 470 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027N* P=0.506N P=0.273 P=0.056N | P<0.001N** P=0.087N P=0.069N P<0.001N** |
|INCIDENTAL TUMOR | P=0.028N* P=0.298 P=0.268 P=0.096N | P<0.001N** P=0.023N* P=0.146N P<0.001N** |
|LOGISTIC REGRESSION | P=0.034N* P=0.392 P=0.514 P=0.084N | P<0.001N** P=0.016N* P=0.144N P<0.001N** |
|COCHRAN-ARMITAGE | P=0.076N | P<0.001N** |
|FISHER EXACT | P=0.549 P=0.426N P=0.107N | P=0.017N* P=0.135N P<0.001N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/84 (29%) 6/20 (30%) 23/88 (26%) 19/97 (20%) | 52/91 (57%) 15/43 (35%) 48/100 (48%) 26/100 (26%)|
|ADJUSTED (b) | 49.1% 76.9% 71.4% 28.6% | 67.3% 56.3% 64.4% 33.4% |
|TERMINAL (d) | 14/34 (41%) 3/4 (75%) 8/12 (67%) 10/53 (19%) | 28/51 (55%) 10/20 (50%) 30/51 (59%) 19/69 (28%) |
|FIRST INCIDENCE (DAYS) | 519 617 518 568 | 470 425 470 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027N* P=0.506N P=0.273 P=0.056N | P<0.001N** P=0.074N P=0.067N P<0.001N** |
|INCIDENTAL TUMOR | P=0.028N* P=0.298 P=0.268 P=0.096N | P<0.001N** P=0.018N* P=0.138N P<0.001N** |
|LOGISTIC REGRESSION | P=0.034N* P=0.392 P=0.514 P=0.084N | P<0.001N** P=0.012N* P=0.140N P<0.001N** |
|COCHRAN-ARMITAGE | P=0.076N | P<0.001N** |
|FISHER EXACT | P=0.549 P=0.426N P=0.107N | P=0.013N* P=0.132N P<0.001N** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 1/100 (1%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.6% 1.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 1/71 (1%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 709 639 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.397 (e) P=0.324 P=0.500 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.384 (e) P=0.337 P=0.485 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.394 (e) P=0.334 P=0.518 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.397 | (e) |
|FISHER EXACT | (e) P=0.359 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 5/150 (3%) 2/100 (2%) | 1/100 (1%) 0/50 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 3.0% 0.0% 5.8% 3.6% | 1.7% 0.0% 0.9% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 2/71 (3%) 1/53 (2%) | 1/60 (2%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 666 --- 518 722 | 729 (T) --- 699 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.555 P=0.365N P=0.402 P=0.664N | P=0.391N P=0.659N P=0.648N P=0.472N |
|INCIDENTAL TUMOR | P=0.567 P=0.547N P=0.407 P=0.659 | P=0.464N P=0.659N P=0.690N P=0.472N |
|LOGISTIC REGRESSION | P=0.551 P=0.402N P=0.408 P=0.692 | P=0.413N P=0.659N P=0.660N P=0.472N |
|COCHRAN-ARMITAGE | P=0.555 | P=0.419N |
|FISHER EXACT | P=0.443N P=0.418 P=0.689N | P=0.667N P=0.641N P=0.500N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 1/150 (1%) 3/100 (3%) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 3.3% 0.0% 1.4% 4.7% | 1.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/50 (2%) 0/33 (0%) 1/71 (1%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 658 --- 732 (T) 666 | 677 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.235 P=0.363N P=0.373N P=0.526 | P=0.438N P=0.644N P=0.414N P=0.495N |
|INCIDENTAL TUMOR | P=0.215 P=0.429N P=0.363N P=0.451 | P=0.535N P=0.648N P=0.473N P=0.629N |
|LOGISTIC REGRESSION | P=0.227 P=0.397N P=0.360N P=0.497 | P=0.442N P=0.639N P=0.421N P=0.500N |
|COCHRAN-ARMITAGE | P=0.231 | P=0.443N |
|FISHER EXACT | P=0.443N P=0.351N P=0.500 | P=0.667N P=0.400N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 0/50 (0%) 3/150 (2%) 3/100 (3%) | 2/100 (2%) 0/50 (0%) 4/150 (3%) 1/100 (1%) |
|ADJUSTED (b) | 5.3% 0.0% 4.2% 4.7% | 3.0% 0.0% 4.0% 1.4% |
|TERMINAL (d) | 2/50 (4%) 0/33 (0%) 3/71 (4%) 0/53 (0%) | 1/60 (2%) 0/27 (0%) 3/99 (3%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 658 --- 732 (T) 666 | 677 --- 707 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.437 P=0.223N P=0.488N P=0.632N | P=0.427N P=0.417N P=0.572 P=0.465N |
|INCIDENTAL TUMOR | P=0.423 P=0.262N P=0.481N P=0.625 | P=0.503N P=0.420N P=0.519 P=0.541N |
|LOGISTIC REGRESSION | P=0.431 P=0.253N P=0.461N P=0.659 | P=0.461N P=0.402N P=0.553 P=0.494N |
|COCHRAN-ARMITAGE | P=0.436 | P=0.482N |
|FISHER EXACT | P=0.293N P=0.456N P=0.659N | P=0.443N P=0.544 P=0.500N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 1/100 (1%) 0/50 (0%) 4/150 (3%) 1/100 (1%) |
|ADJUSTED (b) | 2.0% 0.0% 2.8% 0.0% | 1.7% 0.0% 4.0% 1.4% |
|TERMINAL (d) | 1/50 (2%) 0/33 (0%) 2/71 (3%) 0/53 (0%) | 1/60 (2%) 0/27 (0%) 3/99 (3%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 732 (T) --- 732 (T) --- | 729 (T) --- 707 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.405N P=0.583N P=0.621 P=0.488N | P=0.588N P=0.659N P=0.358 P=0.730N |
|INCIDENTAL TUMOR | P=0.405N P=0.583N P=0.621 P=0.488N | P=0.633N P=0.659N P=0.330 P=0.730N |
|LOGISTIC REGRESSION | P=0.405N P=0.583N P=0.621 P=0.488N | P=0.609N P=0.659N P=0.346 P=0.730N |
|COCHRAN-ARMITAGE | P=0.402N | P=0.638 |
|FISHER EXACT | P=0.667N P=0.649 P=0.500N | P=0.667N P=0.335 P=0.751N |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 1/100 (1%) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.6% 1.2% | 1.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 1/71 (1%) 0/53 (0%) | 1/60 (2%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 709 639 | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.397 (e) P=0.324 P=0.500 | P=0.420N P=0.659N P=0.400N P=0.472N |
|INCIDENTAL TUMOR | P=0.384 (e) P=0.337 P=0.485 | P=0.420N P=0.659N P=0.400N P=0.472N |
|LOGISTIC REGRESSION | P=0.394 (e) P=0.334 P=0.518 | P=0.420N P=0.659N P=0.400N P=0.472N |
|COCHRAN-ARMITAGE | P=0.397 | P=0.443N |
|FISHER EXACT | (e) P=0.359 P=0.500 | P=0.667N P=0.400N P=0.500N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/100 (5%) 0/50 (0%) 9/150 (6%) 6/100 (6%) | 4/100 (4%) 0/50 (0%) 5/150 (3%) 1/100 (1%) |
|ADJUSTED (b) | 8.2% 0.0% 11.3% 9.2% | 6.3% 0.0% 4.9% 1.4% |
|TERMINAL (d) | 2/50 (4%) 0/33 (0%) 6/71 (8%) 1/53 (2%) | 3/60 (5%) 0/27 (0%) 3/99 (3%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 658 --- 518 639 | 677 --- 699 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.294 P=0.102N P=0.456 P=0.540 | P=0.184N P=0.205N P=0.479N P=0.150N |
|INCIDENTAL TUMOR | P=0.285 P=0.167N P=0.465 P=0.441 | P=0.249N P=0.206N P=0.545N P=0.184N |
|LOGISTIC REGRESSION | P=0.280 P=0.127N P=0.477 P=0.431 | P=0.210N P=0.192N P=0.503N P=0.169N |
|COCHRAN-ARMITAGE | P=0.289 | P=0.229N |
|FISHER EXACT | P=0.127N P=0.485 P=0.500 | P=0.194N P=0.518N P=0.184N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 4/50 (8%) 3/150 (2%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 3.4% 11.3% 3.5% 0.0% | 0.0% 0.0% 0.8% 0.0% |
|TERMINAL (d) | 1/50 (2%) 3/33 (9%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 666 654 664 --- | --- --- 606 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.062N P=0.155 P=0.670 P=0.229N | P=0.773N (e) P=0.583 (e) |
|INCIDENTAL TUMOR | P=0.060N P=0.093 P=0.653N P=0.249N | P=0.800N (e) P=0.598 (e) |
|LOGISTIC REGRESSION | P=0.060N P=0.105 P=0.678N P=0.240N | P=0.745N (e) P=0.555 (e) |
|COCHRAN-ARMITAGE | P=0.059N | P=0.770N |
|FISHER EXACT | P=0.096 P=0.665N P=0.249N | (e) P=0.600 (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 1/100 (1%) 0/50 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 1.8% 0.0% 1.7% 0.0% | 1.6% 0.0% 0.8% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 716 --- 568 --- | 707 --- 659 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.403N P=0.590N P=0.640 P=0.489N | P=0.401N P=0.658N P=0.654N P=0.477N |
|INCIDENTAL TUMOR | P=0.415N P=0.755N P=0.660 P=0.530N | P=0.550N P=0.648N P=0.733N P=0.629N |
|LOGISTIC REGRESSION | P=0.392N P=0.618N P=0.648 P=0.496N | P=0.420N P=0.641N P=0.669N P=0.498N |
|COCHRAN-ARMITAGE | P=0.402N | P=0.419N |
|FISHER EXACT | P=0.667N P=0.649 P=0.500N | P=0.667N P=0.641N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 1/100 (1%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.0% 1.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 533 209 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.394 (e) P=0.324 P=0.500 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.428 (e) P=0.311 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.528 (e) P=0.352 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.397 | (e) |
|FISHER EXACT | (e) P=0.359 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 4/50 (8%) 5/150 (3%) 0/100 (0%) | 1/100 (1%) 0/50 (0%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 5.2% 11.3% 5.2% 0.0% | 1.6% 0.0% 1.6% 0.0% |
|TERMINAL (d) | 1/50 (2%) 3/33 (9%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 666 654 568 --- | 707 --- 606 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044N* P=0.263 P=0.582 P=0.115N | P=0.388N P=0.658N P=0.652 P=0.477N |
|INCIDENTAL TUMOR | P=0.042N* P=0.144 P=0.625 P=0.137N | P=0.522N P=0.648N P=0.587 P=0.629N |
|LOGISTIC REGRESSION | P=0.042N* P=0.192 P=0.587 P=0.122N | P=0.391N P=0.641N P=0.626 P=0.498N |
|COCHRAN-ARMITAGE | P=0.040N* | P=0.402N |
|FISHER EXACT | P=0.168 P=0.595 P=0.123N | P=0.667N P=0.649 P=0.500N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 0/150 (0%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 4.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/50 (4%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 732 (T) --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.208N P=0.334N P=0.166N P=0.226N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.208N P=0.334N P=0.166N P=0.226N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.208N P=0.334N P=0.166N P=0.226N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.204N | (e) |
|FISHER EXACT | P=0.443N P=0.159N P=0.249N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 97/100 (97%) 47/50 (94%) 144/147 (98%) 91/98 (93%) | |
|ADJUSTED (b) | 99.0% 100.0% 100.0% 100.0% | |
|TERMINAL (d) | 49/50 (98%) 33/33 (100%) 68/68 (100%) 53/53 (100%)| |
|FIRST INCIDENCE (DAYS) | 416 549 307 399 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.305N P=0.030N* P=0.404 P=0.173N | |
|INCIDENTAL TUMOR | P=0.060N P=0.595 P=0.368 P=0.141N | |
|LOGISTIC REGRESSION | P=0.131N P=0.475N P=0.301 P=0.195N | |
|COCHRAN-ARMITAGE | P=0.111N | |
|FISHER EXACT | P=0.317N P=0.466 P=0.157N | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/75 (29%) 7/14 (50%) 17/72 (24%) 24/97 (25%) | 20/68 (29%) 5/19 (26%) 6/46 (13%) 10/99 (10%) |
|ADJUSTED (b) | 33.8% 100.0% 15.2% 36.0% | 40.7% 0.0% 52.0% 13.0% |
|TERMINAL (d) | 4/29 (14%) 1/1 (100%) 0/4 (0%) 13/53 (25%) | 10/31 (32%) 0/0 1/2 (50%) 5/69 (7%) |
|FIRST INCIDENCE (DAYS) | 519 549 518 568 | 484 575 586 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.417N P=0.285N P=0.087N P=0.351N | P<0.001N** P=0.588 P=0.049N* P=0.002N** |
|INCIDENTAL TUMOR | P=0.381N P=0.227 P=0.064N P=0.454N | P=0.003N** P=0.587N P=0.089N P=0.006N** |
|LOGISTIC REGRESSION | P=0.190N P=0.128 P=0.239N P=0.295N | P<0.001N** P=0.577N P=0.072N P=0.001N** |
|COCHRAN-ARMITAGE | P=0.205N | P=0.001N** |
|FISHER EXACT | P=0.116 P=0.275N P=0.307N | P=0.519N P=0.033N* P=0.001N** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/75 (3%) 0/14 (0%) 3/72 (4%) 5/97 (5%) | 2/68 (3%) 0/19 (0%) 0/46 (0%) 0/99 (0%) |
|ADJUSTED (b) | 6.9% 0.0% 50.5% 7.0% | 2.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/29 (7%) 0/1 (0%) 2/4 (50%) 1/53 (2%) | 0/31 (0%) 0/0 0/2 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 732 (T) --- 690 428 | 629 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.327 P=0.959N P=0.038 * P=0.339 | P=0.197N P=0.413N P=0.150N P=0.230N |
|INCIDENTAL TUMOR | P=0.336 P=0.959N P=0.037 * P=0.300 | P=0.245N P=0.350N P=0.184N P=0.292N |
|LOGISTIC REGRESSION | P=0.253 P=0.959N P=0.153 P=0.327 | P=0.142N P=0.548N P=0.339N P=0.161N |
|COCHRAN-ARMITAGE | P=0.243 | P=0.143N |
|FISHER EXACT | P=0.709N P=0.481 P=0.340 | P=0.609N P=0.354N P=0.164N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/75 (32%) 7/14 (50%) 20/72 (28%) 28/97 (29%) | 22/68 (32%) 5/19 (26%) 6/46 (13%) 10/99 (10%) |
|ADJUSTED (b) | 39.1% 100.0% 58.1% 40.1% | 42.3% 0.0% 52.0% 13.0% |
|TERMINAL (d) | 6/29 (21%) 1/1 (100%) 2/4 (50%) 14/53 (26%) | 10/31 (32%) 0/0 1/2 (50%) 5/69 (7%) |
|FIRST INCIDENCE (DAYS) | 519 549 518 428 | 484 575 586 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.458N P=0.276N P=0.242N P=0.421N | P<0.001N** P=0.490N P=0.016N* P<0.001N** |
|INCIDENTAL TUMOR | P=0.422N P=0.242 P=0.228N P=0.541N | P=0.001N** P=0.401N P=0.031N* P=0.002N** |
|LOGISTIC REGRESSION | P=0.264N P=0.166 P=0.355N P=0.385N | P<0.001N** P=0.474N P=0.037N* P<0.001N** |
|COCHRAN-ARMITAGE | P=0.287N | P<0.001N** |
|FISHER EXACT | P=0.160 P=0.353N P=0.390N | P=0.420N P=0.015N* P<0.001N** |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/75 (4%) 0/14 (0%) 0/72 (0%) 1/97 (1%) | 1/68 (1%) 0/19 (0%) 1/46 (2%) 1/99 (1%) |
|ADJUSTED (b) | 6.2% 0.0% 0.0% 1.8% | 3.2% 0.0% 0.7% 1.4% |
|TERMINAL (d) | 1/29 (3%) 0/1 (0%) 0/4 (0%) 0/53 (0%) | 1/31 (3%) 0/0 0/2 (0%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 645 --- --- 725 | 729 (T) --- 536 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.284N P=0.365N P=0.137N P=0.244N | P=0.454N (e) P=0.621 P=0.573N |
|INCIDENTAL TUMOR | P=0.290N P=0.523N P=0.142N P=0.291N | P=0.496N (e) P=0.571 P=0.573N |
|LOGISTIC REGRESSION | P=0.222N P=0.538N P=0.145N P=0.208N | P=0.582N (e) P=0.692 P=0.573N |
|COCHRAN-ARMITAGE | P=0.253N | P=0.584N |
|FISHER EXACT | P=0.595N P=0.130N P=0.221N | P=0.782N P=0.646 P=0.650N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/75 (4%) 0/14 (0%) 0/72 (0%) 2/97 (2%) | 1/68 (1%) 0/19 (0%) 1/46 (2%) 1/99 (1%) |
|ADJUSTED (b) | 6.2% 0.0% 0.0% 3.6% | 3.2% 0.0% 0.7% 1.4% |
|TERMINAL (d) | 1/29 (3%) 0/1 (0%) 0/4 (0%) 1/53 (2%) | 1/31 (3%) 0/0 0/2 (0%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | 645 --- --- 725 | 729 (T) --- 536 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.463N P=0.365N P=0.137N P=0.381N | P=0.454N (e) P=0.621 P=0.573N |
|INCIDENTAL TUMOR | P=0.472N P=0.523N P=0.142N P=0.433N | P=0.496N (e) P=0.571 P=0.573N |
|LOGISTIC REGRESSION | P=0.413N P=0.538N P=0.145N P=0.356N | P=0.582N (e) P=0.692 P=0.573N |
|COCHRAN-ARMITAGE | P=0.484N | P=0.584N |
|FISHER EXACT | P=0.595N P=0.130N P=0.380N | P=0.782N P=0.646 P=0.650N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% 0.0% | 0.0% 0.0% 1.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 1/71 (1%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 1/99 (1%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 704 --- | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.662N (e) P=0.329 (e) | P=0.748N (e) P=0.600 (e) |
|INCIDENTAL TUMOR | P=0.671N (e) P=0.337 (e) | P=0.748N (e) P=0.600 (e) |
|LOGISTIC REGRESSION | P=0.665N (e) P=0.334 (e) | P=0.748N (e) P=0.600 (e) |
|COCHRAN-ARMITAGE | P=0.664N | P=0.770N |
|FISHER EXACT | (e) P=0.359 (e) | (e) P=0.600 (e) |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 1/71 (1%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 704 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.662N (e) P=0.329 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.671N (e) P=0.337 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.665N (e) P=0.334 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.664N | (e) |
|FISHER EXACT | (e) P=0.359 (e) | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Uterus |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/100 (0%) 0/50 (0%) 3/150 (2%) 1/100 (1%) |
|ADJUSTED (b) | | 0.0% 0.0% 2.6% 1.4% |
|TERMINAL (d) | | 0/60 (0%) 0/27 (0%) 0/99 (0%) 1/69 (1%) |
|FIRST INCIDENCE (DAYS) | | --- --- 630 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.462 (e) P=0.212 P=0.528 |
|INCIDENTAL TUMOR | | P=0.342 (e) P=0.169 P=0.528 |
|LOGISTIC REGRESSION | | P=0.440 (e) P=0.195 P=0.528 |
|COCHRAN-ARMITAGE | | P=0.438 |
|FISHER EXACT | | (e) P=0.214 P=0.500 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 11/100 (11%) 6/50 (12%) 35/150 (23%) 18/100 (18%)|
|ADJUSTED (b) | | 15.3% 17.6% 31.0% 24.2% |
|TERMINAL (d) | | 6/60 (10%) 2/27 (7%) 24/99 (24%) 14/69 (20%) |
|FIRST INCIDENCE (DAYS) | | 388 593 512 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.294 P=0.481 P=0.025 * P=0.184 |
|INCIDENTAL TUMOR | | P=0.120 P=0.544 P=0.010 ** P=0.111 |
|LOGISTIC REGRESSION | | P=0.158 P=0.531 P=0.012 * P=0.112 |
|COCHRAN-ARMITAGE | | P=0.164 |
|FISHER EXACT | | P=0.527 P=0.010 ** P=0.114 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/100 (1%) 0/50 (0%) 3/150 (2%) 2/100 (2%) |
|ADJUSTED (b) | | 1.4% 0.0% 2.6% 2.7% |
|TERMINAL (d) | | 0/60 (0%) 0/27 (0%) 1/99 (1%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | | 698 --- 509 672 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.389 P=0.659N P=0.486 P=0.528 |
|INCIDENTAL TUMOR | | P=0.201 P=0.648N P=0.391 P=0.278 |
|LOGISTIC REGRESSION | | P=0.361 P=0.639N P=0.444 P=0.499 |
|COCHRAN-ARMITAGE | | P=0.355 |
|FISHER EXACT | | P=0.667N P=0.475 P=0.500 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 12/100 (12%) 6/50 (12%) 38/150 (25%) 20/100 (20%)|
|ADJUSTED (b) | | 16.5% 17.6% 33.0% 26.2% |
|TERMINAL (d) | | 6/60 (10%) 2/27 (7%) 25/99 (25%) 14/69 (20%) |
|FIRST INCIDENCE (DAYS) | | 388 593 509 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.239 P=0.545 P=0.020 * P=0.155 |
|INCIDENTAL TUMOR | | P=0.066 P=0.600N P=0.006 ** P=0.060 |
|LOGISTIC REGRESSION | | P=0.114 P=0.601 P=0.008 ** P=0.086 |
|COCHRAN-ARMITAGE | | P=0.120 |
|FISHER EXACT | | P=0.613N P=0.007 ** P=0.088 |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 3/150 (2%) 1/100 (1%) | 1/100 (1%) 1/50 (2%) 1/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 2.3% 1.0% | 1.2% 2.3% 0.8% 1.1% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 568 438 | 644 621 624 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.430 (e) P=0.207 P=0.494 | P=0.618N P=0.589 P=0.669N P=0.756 |
|INCIDENTAL TUMOR | P=0.461 (e) P=0.198 P=0.527 | P=0.678N P=0.744 P=0.649N P=0.766 |
|LOGISTIC REGRESSION | P=0.520 (e) P=0.229 P=0.715 | P=0.566N P=0.582 P=0.689N P=0.748N |
|COCHRAN-ARMITAGE | P=0.438 | P=0.613N |
|FISHER EXACT | (e) P=0.214 P=0.500 | P=0.557 P=0.641N P=0.751N |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 4/150 (3%) 1/100 (1%) | 1/100 (1%) 1/50 (2%) 1/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 3.2% 1.0% | 1.2% 2.3% 0.8% 1.1% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 568 438 | 644 621 624 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.464 (e) P=0.134 P=0.494 | P=0.618N P=0.589 P=0.669N P=0.756 |
|INCIDENTAL TUMOR | P=0.487 (e) P=0.130 P=0.527 | P=0.678N P=0.744 P=0.649N P=0.766 |
|LOGISTIC REGRESSION | P=0.543 (e) P=0.144 P=0.715 | P=0.566N P=0.582 P=0.689N P=0.748N |
|COCHRAN-ARMITAGE | P=0.470 | P=0.613N |
|FISHER EXACT | (e) P=0.128 P=0.500 | P=0.557 P=0.641N P=0.751N |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 29
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 3/150 (2%) 1/100 (1%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.9% 1.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 533 209 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.436 (e) P=0.201 P=0.500 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.462 (e) P=0.197 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.549 (e) P=0.215 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.438 | (e) |
|FISHER EXACT | (e) P=0.214 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 3/150 (2%) 1/100 (1%) | 0/100 (0%) 1/50 (2%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.9% 1.0% | 0.0% 2.8% 0.0% 0.0% |
|TERMINAL (d) | 0/50 (0%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 533 209 | --- 681 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.436 (e) P=0.201 P=0.500 | P=0.542N P=0.359 (e) (e) |
|INCIDENTAL TUMOR | P=0.462 (e) P=0.197 (e) | P=0.649N P=0.352 (e) (e) |
|LOGISTIC REGRESSION | P=0.549 (e) P=0.215 (e) | P=0.548N P=0.361 (e) (e) |
|COCHRAN-ARMITAGE | P=0.438 | P=0.548N |
|FISHER EXACT | (e) P=0.214 P=0.500 | P=0.333 (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 30
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 50/100 (50%) 22/50 (44%) 55/150 (37%) 39/100 (39%)| 29/100 (29%) 21/50 (42%) 34/150 (23%) 21/100 (21%)|
|ADJUSTED (b) | 58.6% 51.7% 49.4% 46.3% | 36.8% 52.9% 26.9% 26.1% |
|TERMINAL (d) | 17/50 (34%) 13/33 (39%) 21/71 (30%) 12/53 (23%) | 13/60 (22%) 10/27 (37%) 13/99 (13%) 12/69 (17%) |
|FIRST INCIDENCE (DAYS) | 416 549 426 425 | 484 425 519 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.176N P=0.120N P=0.065N P=0.102N | P=0.024N* P=0.069 P=0.128N P=0.085N |
|INCIDENTAL TUMOR | P=0.119N P=0.458 P=0.021N* P=0.109N | P=0.131N P=0.081 P=0.227N P=0.284N |
|LOGISTIC REGRESSION | P=0.148N P=0.489N P=0.033N* P=0.132N | P=0.079N P=0.080 P=0.154N P=0.177N |
|COCHRAN-ARMITAGE | P=0.116N | P=0.037N* |
|FISHER EXACT | P=0.302N P=0.025N* P=0.077N | P=0.080 P=0.163N P=0.126N |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 1/50 (2%) 7/150 (5%) 3/100 (3%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 5.0% 2.6% 6.4% 5.5% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/50 (2%) 0/33 (0%) 1/71 (1%) 2/53 (4%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 667 673 410 725 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.590 P=0.496N P=0.375 P=0.628N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.575N P=0.704N P=0.355 P=0.640 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.576N P=0.571N P=0.405 P=0.657N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.593 | (e) |
|FISHER EXACT | P=0.593N P=0.379 P=0.659N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 31
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 2/150 (1%) 1/100 (1%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 2.0% 0.0% 1.8% 1.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/50 (2%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 732 (T) --- 652 609 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.609 P=0.583N P=0.639 P=0.756N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.601 P=0.583N P=0.654 P=0.759 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.622 P=0.583N P=0.639 P=0.759N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.613 | (e) |
|FISHER EXACT | P=0.667N P=0.649 P=0.751N | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 2/150 (1%) 1/100 (1%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 2.0% 0.0% 1.8% 1.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/50 (2%) 0/33 (0%) 0/71 (0%) 0/53 (0%) | 0/60 (0%) 0/27 (0%) 0/99 (0%) 0/69 (0%) |
|FIRST INCIDENCE (DAYS) | 732 (T) --- 652 609 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.609 P=0.583N P=0.639 P=0.756N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.601 P=0.583N P=0.654 P=0.759 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.622 P=0.583N P=0.639 P=0.759N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.613 | (e) |
|FISHER EXACT | P=0.667N P=0.649 P=0.751N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 32
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) |100/100 (100% 48/50 (96%) 147/150 (98%) 97/100 (97%)| 74/100 (74%) 27/50 (54%) 94/150 (63%) 52/100 (52%)|
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 79.4% 64.5% 70.7% 62.3% |
|TERMINAL (d) | 50/50 (100%) 33/33 (100%) 71/71 (100%) 53/53 (100%)| 41/60 (68%) 13/27 (48%) 61/99 (62%) 38/69 (55%) |
|FIRST INCIDENCE (DAYS) | 416 549 307 399 | 388 425 439 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.475N P=0.024N* P=0.532 P=0.273N | P=0.002N** P=0.117N P=0.031N* P<0.001N** |
|INCIDENTAL TUMOR | P=0.268N (e) P=0.262N P=0.262N | P=0.020N* P=0.004N** P=0.041N* P=0.003N** |
|LOGISTIC REGRESSION | P=0.464N (e) P=0.443N P=0.401N | P=0.014N* P=0.003N** P=0.026N* P=0.002N** |
|COCHRAN-ARMITAGE | P=0.234N | P=0.005N** |
|FISHER EXACT | P=0.110N P=0.214N P=0.123N | P=0.012N* P=0.041N* P=0.001N** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 66/100 (66%) 28/50 (56%) 82/150 (55%) 56/100 (56%)| 43/100 (43%) 23/50 (46%) 50/150 (33%) 30/100 (30%)|
|ADJUSTED (b) | 71.4% 59.2% 63.0% 60.0% | 50.7% 56.7% 37.3% 35.5% |
|TERMINAL (d) | 24/50 (48%) 14/33 (42%) 27/71 (38%) 17/53 (32%) | 19/60 (32%) 11/27 (41%) 18/99 (18%) 16/69 (23%) |
|FIRST INCIDENCE (DAYS) | 416 340 307 209 | 388 425 491 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.276N P=0.060N P=0.144N P=0.141N | P=0.016N* P=0.331 P=0.068N P=0.028N* |
|INCIDENTAL TUMOR | P=0.165N P=0.435N P=0.032N* P=0.112N | P=0.134N P=0.478 P=0.129N P=0.155N |
|LOGISTIC REGRESSION | P=0.182N P=0.353N P=0.058N P=0.110N | P=0.064N P=0.432 P=0.058N P=0.065N |
|COCHRAN-ARMITAGE | P=0.179N | P=0.023N* |
|FISHER EXACT | P=0.155N P=0.049N* P=0.096N | P=0.430 P=0.079N P=0.039N* |
|=================================================================================================================================|
DATE: 09/09/94 EXPERIMENT: 05075 TEST: 01 PAGE 33
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- DIPHENYLHYDANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 240 PPM 800 PPM 2400 PPM | 0 PPM 240 PPM 800 PPM 2400 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) |100/100 (100% 49/50 (98%) 149/150 (99%) 99/100 (99%)| 85/100 (85%) 40/50 (80%) 116/150 (77%) 65/100 (65%)|
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 87.6% 81.6% 79.4% 73.0% |
|TERMINAL (d) | 50/50 (100%) 33/33 (100%) 71/71 (100%) 53/53 (100%)| 48/60 (80%) 18/27 (67%) 69/99 (70%) 45/69 (65%) |
|FIRST INCIDENCE (DAYS) | 416 340 307 209 | 388 425 439 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.511 P=0.037N* P=0.474 P=0.347N | P=0.001N** P=0.522 P=0.076N P=0.002N** |
|INCIDENTAL TUMOR | P=0.576N (e) (e) P=0.527N | P=0.008N** P=0.119N P=0.099N P=0.005N** |
|LOGISTIC REGRESSION | P=0.669 (e) (e) P=0.622N | P=0.004N** P=0.111N P=0.066N P=0.002N** |
|COCHRAN-ARMITAGE | P=0.538N | P<0.001N** |
|FISHER EXACT | P=0.333N P=0.600N P=0.500N | P=0.290N P=0.090N P<0.001N** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).