TDMS Study 05075-01 Pathology Tables
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57-41-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|
| 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic Active, Focal | |
Ulcer | |
Submucosa, Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Fatty Change | 1 4 3 4 |
Mixed Cell Focus | |
Necrosis, Coagulative, Multifocal | |
Regeneration, Focal | |
Sinusoid, Angiectasis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 3 |
Artery, Inflammation, Chronic | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 2 2 3 2 1 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Parotid Gland, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
Submucosa, Edema | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | |
Myocardium, Degeneration, Multifocal | 2 2 1 2 1 1 3 2 1 2 3 2 2 |
Myocardium, Fibrosis, Focal | 2|
Myocardium, Inflammation, Chronic, | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|
| 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Focal | |
Congestion | 4 |
Hyperplasia, Nodular | 2 1 2 4 1 1 2 3 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + M + + + M + + + + + + +|
Hyperplasia, Diffuse | |
Hyperplasia, Nodular | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Nodular | 1 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | 4 2 2 2 2 2 2 4 2 2 4 3 3 2 4 3 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + M + M +|
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 2 3 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 1|
Corpus Luteum, Congestion | 3 |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prolapse | X X X |
Endometrium, Bacterium | X |
Endometrium, Hyperplasia, Cystic | 1 1 2 |
Endometrium, Necrosis, Coagulative | |
Wall, Inflammation, Chronic Active | 3 3 |
Wall, Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Vagina | + |
Lamina Propria, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|
| 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrotizing | |
Wall, Edema | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Angiectasis | 4 |
Femoral, Hyperplasia | 2 2 1 |
Femoral, Hyperplasia, Re Cell | 4 |
Femoral, Hypoplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma, Single | 1 |
Hematopoietic Cell Proliferation | 3 3 2 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + M +|
Arteriole, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 3 3 2 1 3 2 1 1 2 2 3 |
Duct, Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Hyperkeratosis | 4 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
Femur, Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 4 3 1 3 3 2 2 2 2 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchus, Foreign Body | 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 3| 7| 7| 7| 6| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 2| 0| 2| 2| 2| 8| 3| 9| 3| 5| 3| 1| 3| 8| 3| 3| 3| 5| 3| 9| 0| 5| 3| 9| 3|
| 9| 2| 9| 9| 9| 6| 0| 5| 0| 7| 0| 3| 0| 8| 1| 1| 1| 9| 1| 3| 0| 5| 2| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Inflammation, Chronic, | |
Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Inflammation, Chronic| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + |
Lens Crystalline, Cataract | 4 3 |
Lids, Inflammation, Suppurative | 1 |
Retina, Atrophy | 4 3 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation, Multifocal, Necrotizing| |
Nephropathy, Multifocal | 1 2 1 1 3 1 2 1 2 1 1 1 1 1 1 1|
Pelvis, Renal Tubule, Bacterium | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | |
Transitional Epithelium, Hyperplasia,| |
Diffuse | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3| |
| 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Inflammation, Chronic Active, Focal | 3 | 1 3.0|
Ulcer | 4 | 1 4.0|
Submucosa, Edema | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X 1 X X X X X X X X X X X X X X| 40 1.0|
Clear Cell Focus | X | 1 |
Fatty Change | 1 | 5 2.6|
Mixed Cell Focus | X | 1 |
Necrosis, Coagulative, Multifocal | 2 | 1 2.0|
Regeneration, Focal | 2 2 | 2 2.0|
Sinusoid, Angiectasis | 2 2 1| 3 1.7|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic | | 1 3.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 1 2 1 3 2 1 1 1 1| 21 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Parotid Gland, Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Submucosa, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Inflammation, Chronic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3| |
| 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Coronary Artery, Inflammation, | | |
Chronic | 3 | 1 3.0|
Myocardium, Degeneration, Multifocal | 2 2 1 2 2 2 1 1 2 1 1 1 2 1 1 1 1 1 1| 32 1.6|
Myocardium, Fibrosis, Focal | | 1 2.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular, Focal | 1 | 1 1.0|
Congestion | | 1 4.0|
Hyperplasia, Nodular | 1 1 1 1 1 2 2 1 1 1| 19 1.6|
Hypertrophy, Focal | 2 2 1| 3 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Nodular | | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + M + + + + + + + + + +| 45 |
Hyperplasia, Diffuse | 3 | 1 3.0|
Hyperplasia, Nodular | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia, Nodular | 2 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 2 2 2 4 2 2 2 3 2 2 3 3 1 2 1 | 33 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M + + + M + + + + + + +| 45 |
Hyperplasia | 3 | 2 2.5|
Inflammation, Chronic | 1 1 | 6 1.0|
Inflammation, Chronic Active | 2 | 3 2.3|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 | 5 1.4|
Corpus Luteum, Congestion | | 1 3.0|
Follicle, Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3| |
| 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Periovarian Tissue, Cyst | X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prolapse | | 3 |
Endometrium, Bacterium | | 1 |
Endometrium, Hyperplasia, Cystic | 1 1 2 2 2 2| 9 1.6|
Endometrium, Necrosis, Coagulative | 4 | 1 4.0|
Wall, Inflammation, Chronic Active | | 2 3.0|
Wall, Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + | 2 |
Lamina Propria, Inflammation, | | |
Necrotizing | 4 | 1 4.0|
Wall, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Polychromasia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Angiectasis | | 1 4.0|
Femoral, Hyperplasia | 2 3 2 1 | 7 1.9|
Femoral, Hyperplasia, Re Cell | | 1 4.0|
Femoral, Hypoplasia | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma, Single | | 1 1.0|
Hematopoietic Cell Proliferation | | 3 2.7|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + M + + + + + + + + + + +| 46 |
Arteriole, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 1 1 3 3 3 3 1 2 2 2 3 1 1 3 3 1 2 1| 32 2.0|
Duct, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 4.0|
Hyperkeratosis | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 8| 8| 3| 2| 7| 2| 3| 3| 3| 3| |
| 2| 2| 6| 6| 6| 6| 6| 7| 0| 7| 7| 7| 8| 8| 0| 4| 4| 8| 9| 7| 1| 8| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 3.0|
Femur, Osteopetrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypothalamus, Compression | 4 3 4 2 | 15 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Bronchus, Foreign Body | | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lamina Propria, Inflammation, Chronic| 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | + + + + + +| 9 |
Lens Crystalline, Cataract | 3 4 1 3 4| 7 3.1|
Lids, Inflammation, Suppurative | | 1 1.0|
Retina, Atrophy | 4 4 3 4 4| 7 3.7|
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Inflammation, Chronic, Multifocal | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 4 | 1 4.0|
Inflammation, Multifocal, Necrotizing| 3 | 1 3.0|
Nephropathy, Multifocal | 1 1 1 2 2 1 1 2 1 2 3 3 2 1 1 1| 32 1.4|
Pelvis, Renal Tubule, Bacterium | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Hemorrhage | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia,| | |
Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|
| 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + |
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Cyst | X |
Fatty Change | 3 |
Granuloma, Multiple | 2 |
Hepatodiaphragmatic Nodule | |
Necrosis, Coagulative, Multifocal | 1 1 |
Necrosis, Caseous | 1 |
Regeneration, Focal | |
Sinusoid, Angiectasis | 1 |
Sinusoid, Angiectasis, Multifocal | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + |
Acinus, Atrophy | 1 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Inflammation, Subacute | 2 |
Mucosa, Proliferation, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + |
Myocardium, Degeneration, Multifocal | 1 2 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
Hyperplasia, Nodular | 1 2 |
Hypertrophy, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|
| 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 1 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Nodular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 3 2 2 3 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + |
Hyperplasia | 3 |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 3 2 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
Follicle, Cyst | |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + |
Dilatation | |
Endometrium, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + |
Femoral, Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Mandibular, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 |
Capsule, Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + I + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 2 3 2 4 3 3 3 4 4 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 5| 2| 9| 2| 9| 3| 3| 1| 0| 3| 2| 3| 2| 5| 3| 0| 3| 3| 3| 9| 3| 3| 8| 3|
| 9| 2| 9| 8| 9| 2| 0| 0| 7| 7| 0| 7| 1| 7| 9| 0| 6| 1| 1| 1| 9| 2| 2| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acanthosis | 1 |
Hyperkeratosis | 2 |
Inflammation, Chronic | 3 |
Inflammation, Necrotizing | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
Infarct | |
Inflammation, Multifocal, Necrotizing| |
Hypothalamus, Compression | 1 4 4 3 4 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Alveolus, Hemorrhage | 3 1 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + |
Sinus, Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens Crystalline, Cataract | 3 |
Posterior Chamber, Inflammation, | |
Chronic | 3 |
Retina, Atrophy | |
Sclera, Mineralization, Multifocal | 2 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
Inflammation, Multifocal, Necrotizing| |
Nephropathy, Multifocal | 2 3 1 1 1 2 |
Papilla, Bacterium | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Mucosa, Hyperplasia, Papillary | 4 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1| |
| 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A +| 20 |
Edema | 3| 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X X X X X | 35 |
Clear Cell Focus | X X | 2 |
Cyst | | 1 |
Fatty Change | 1 2 | 3 2.0|
Granuloma, Multiple | | 1 2.0|
Hepatodiaphragmatic Nodule | X| 1 |
Necrosis, Coagulative, Multifocal | | 2 1.0|
Necrosis, Caseous | | 1 1.0|
Regeneration, Focal | 2 | 1 2.0|
Sinusoid, Angiectasis | | 1 1.0|
Sinusoid, Angiectasis, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + +| 6 |
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | 4 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + A +| 20 |
Acinus, Atrophy | 1 1 2| 7 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A +| 20 |
Inflammation, Subacute | | 1 2.0|
Mucosa, Proliferation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + +| 21 |
Myocardium, Degeneration, Multifocal | 1 1 1 4 | 13 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1| |
| 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + A +| 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + A +| 21 |
Hyperplasia, Nodular | 1 | 3 1.3|
Hypertrophy, Focal | | 1 1.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + A +| 21 |
Hyperplasia, Nodular | 1 1| 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M +| 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| 41 |
Pars Distalis, Angiectasis, Focal | 2 | 2 1.5|
Pars Distalis, Cyst | X X X | 4 |
Pars Distalis, Hyperplasia, Nodular | 1 3 2 | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A +| 20 |
C-Cell, Hyperplasia | 3 1 2 3 2 2 | 14 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + I + + +| 21 |
Hyperplasia | 3 | 2 3.0|
Inflammation, Chronic | | 4 1.0|
Inflammation, Chronic Active | | 2 2.5|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + +| 23 |
Inflammation, Chronic | | 1 3.0|
Follicle, Cyst | X | 1 |
Periovarian Tissue, Cyst | X X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + +| 26 |
Dilatation | 4 3 | 2 3.5|
Endometrium, Hyperplasia, Cystic | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + +| 21 |
Femoral, Hyperplasia | 3 2 3 3| 8 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + A +| 21 |
Mandibular, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1| |
| 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + +| 26 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Capsule, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + I + +| 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + A +| 24 |
Hyperplasia, Cystic | 4 3 3 1 2| 15 2.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + +| 22 |
Acanthosis | | 1 1.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Necrotizing | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + +| 21 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + +| 21 |
Infarct | 3 | 1 3.0|
Inflammation, Multifocal, Necrotizing| 1 | 1 1.0|
Hypothalamus, Compression | 1 | 8 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + +| 22 |
Alveolus, Hemorrhage | 1 | 3 1.7|
Interstitium, Inflammation, Chronic, | | |
Focal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + +| 21 |
Sinus, Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + +| 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
Lens Crystalline, Cataract | 3 4 4 2 | 5 3.2|
Posterior Chamber, Inflammation, | | |
Chronic | 3 3 | 3 3.0|
Retina, Atrophy | 4 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 3| 3| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 2| 8| 3| 3| 3| 6| 0| 3| 9| 3| 3| 3| 4| 3| 8| 3| 3| 1| |
| 6| 6| 6| 6| 7| 7| 0| 5| 8| 7| 7| 8| 1| 7| 8| 9| 8| 8| 9| 4| 9| 3| 9| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Sclera, Mineralization, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + +| 21 |
Inflammation, Multifocal, Necrotizing| 4 | 1 4.0|
Nephropathy, Multifocal | 1 2 1 1 1| 11 1.5|
Papilla, Bacterium | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A +| 21 |
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic | | 1 1.0|
Mucosa, Hyperplasia, Papillary | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|
| 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + +|
Ulcer | 2 |
Submucosa, Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Cyst | X |
Fatty Change, Diffuse | |
Fatty Change | 3 3 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X |
Regeneration, Focal | 3 |
Centrilobular, Cytomegaly | 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Acinus, Atrophy | 2 3 2 1 1 2 2 4|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Tooth | + |
Gingiva, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + +|
Autolysis | 2 |
Coronary Artery, Inflammation, | |
Chronic | 2 |
Myocardium, Degeneration, Multifocal | 1 2 1 2 2 1 3 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
Valve, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|
| 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + +|
Hyperplasia, Nodular | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + +|
Hyperplasia, Nodular | 2 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + +|
Hyperplasia, Diffuse | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 2 |
Pars Distalis, Angiectasis, | |
Multifocal | 3 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Nodular | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + +|
C-Cell, Hyperplasia | 2 2 3 3 3 3 4 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + +|
Autolysis | 1 |
Inflammation, Chronic | 1 1 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + +|
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | |
Prolapse | X |
Cervix, Inflammation, Suppurative | |
Wall, Bacterium | X |
Wall, Inflammation, Necrotizing | 3 |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + I|
Femoral, Hyperplasia | 2 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Mandibular, Inflammation, Chronic | |
Mediastinal, Pigmentation, | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|
| 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemosiderin | 2 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + +|
Fibrosis, Focal | 1 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | |
Capsule, Inflammation, Focal, | |
Subacute | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + +|
Hemorrhage, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 2 2 2 1 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + +|
Tibia, Proliferation | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Infarct | |
Infarct, Multiple | 3 |
Hypothalamus, Compression | 4 3 3 |
Hypothalamus, Hemorrhage, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Alveolus, Hemorrhage, Multifocal | 3 |
Interstitium, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens Crystalline, Cataract | 4 2 3 |
Posterior Chamber, Inflammation, | |
Chronic | 3 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| 6| 6| 7| 6| 6| 7| 7| 5| 7| 7| 6| 7| 5|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 9| 3| 9| 3| 3| 7| 2| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 7|
| 9| 9| 9| 0| 0| 0| 2| 1| 0| 1| 1| 5| 1| 8| 2| 4| 4| 2| 2| 6| 0| 6| 4| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic, Multifocal | 2 1|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + +|
Nephropathy, Multifocal | 2 1 4 1 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3| |
| 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + A | 20 |
Ulcer | | 1 2.0|
Submucosa, Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + A | 20 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + A | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X| 30 |
Cyst | | 1 |
Fatty Change, Diffuse | 2 3 | 2 2.5|
Fatty Change | 2 | 3 2.7|
Hepatodiaphragmatic Nodule | | 1 |
Mixed Cell Focus | | 1 |
Regeneration, Focal | 3 | 2 3.0|
Centrilobular, Cytomegaly | 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 23 |
Fibrosis, Focal | | 1 2.0|
Acinus, Atrophy | 2 1 3 2 1 | 13 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + A | 20 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 24 |
Autolysis | | 1 2.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3| |
| 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Myocardium, Degeneration, Multifocal | 1 1 1 2 1 1 | 13 1.5|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Valve, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 23 |
Hyperplasia, Nodular | 2 1 1 2 2 | 7 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 23 |
Hyperplasia, Nodular | 1 2 | 6 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + M + + | 21 |
Hyperplasia, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + | 43 |
Pars Distalis, Angiectasis, Focal | 2 4 2 | 5 2.4|
Pars Distalis, Angiectasis, | | |
Multifocal | | 1 3.0|
Pars Distalis, Cyst | X X X | 5 |
Pars Distalis, Hyperplasia, Nodular | 2 1 1 1 | 7 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + A A | 19 |
C-Cell, Hyperplasia | 2 3 2 3 2 2 | 14 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + | 24 |
Autolysis | | 1 1.0|
Inflammation, Chronic | 1 1 | 4 1.0|
Duct, Dilatation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 26 |
Periovarian Tissue, Cyst | X X X X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 26 |
Dilatation | 3 | 1 3.0|
Hyperplasia | 3 | 1 3.0|
Prolapse | | 1 |
Cervix, Inflammation, Suppurative | 3 | 1 3.0|
Wall, Bacterium | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3| |
| 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Wall, Inflammation, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 22 |
Femoral, Hyperplasia | 1 3 2 3 2 2 1 | 11 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 26 |
Mandibular, Inflammation, Chronic | 3 | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 2.0|
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 4 |
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 29 |
Fibrosis, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Coagulative | 2 | 1 2.0|
Capsule, Inflammation, Focal, | | |
Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + | 21 |
Hemorrhage, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 31 |
Hyperplasia, Cystic | 2 1 1 2 2 | 12 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 23 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 24 |
Tibia, Proliferation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 23 |
Infarct | 2 | 1 2.0|
Infarct, Multiple | | 1 3.0|
Hypothalamus, Compression | 2 1 | 5 2.6|
Hypothalamus, Hemorrhage, Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 2| 1| 8| 0| 9| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 8| 3| 3| 3| |
| 6| 9| 7| 7| 7| 5| 4| 7| 0| 7| 3| 0| 7| 8| 8| 3| 4| 8| 8| 5| 9| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 24 |
Alveolus, Hemorrhage, Multifocal | 3 | 2 3.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Lens Crystalline, Cataract | 2 4 3 | 6 3.0|
Posterior Chamber, Inflammation, | | |
Chronic | 2 3 | 4 2.8|
Retina, Atrophy | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Inflammation, Chronic, Multifocal | | 2 1.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 23 |
Nephropathy, Multifocal | 1 1 1 | 10 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A A + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Cyst | |
Eosinophilic Focus | X X X |
Mixed Cell Focus | |
Necrosis, Coagulative, Multifocal | 1 |
Necrosis, Caseous, Multifocal | 1 |
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + A + + + +|
Acinus, Atrophy | 3 1 1 |
__________________________________________________________________________|
Salivary Glands | + + A + + + +|
__________________________________________________________________________|
Stomach | + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + A + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + +|
Myocardium, Degeneration, Multifocal | 1 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
Hyperplasia, Nodular | 2 |
Vacuolization Cytoplasmic, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + A + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Autolysis | 3 |
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Nodular | 1|
__________________________________________________________________________|
Thyroid Gland | + + A A + + +|
C-Cell, Hyperplasia | 3 1 4 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + +|
Inflammation, Chronic | 1 1|
Duct, Dilatation | 3 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
Inflammation, Chronic | |
Periovarian Tissue, Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Dilatation | 1 4 |
Endometrium, Hyperplasia, Cystic | 3 |
Wall, Cyst | |
__________________________________________________________________________|
Vagina | + |
Cyst | |
Lumen, Exudate | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + + + +|
Femoral, Hyperplasia | 2 2|
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + A + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Autolysis | 3 |
Fibrosis, Diffuse | 4 |
Hematopoietic Cell Proliferation | |
Capsule, Cyst | |
__________________________________________________________________________|
Thymus | + + A + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + +|
Hyperplasia, Cystic | 4 1 2 4 |
__________________________________________________________________________|
Skin | + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
Femur, Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 3| 3| 3| 1| 0| 3| 3| 3| 9| 7| 3| 5| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 1| 9| 9| 9| 0| 0| 0| 1| 2| 0| 0| 1| 7| 0| 1| 4| 1| 1| 1| 2| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + +|
Hypothalamus, Compression | 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + +|
Alveolus, Inflammation, Multifocal, | |
Suppurative | |
Bronchus, Foreign Body | |
Bronchus, Inflammation, Multifocal, | |
Suppurative | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 1|
__________________________________________________________________________|
Nose | + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
Cornea, Inflammation, Suppurative | |
Lens Crystalline, Cataract | 2 3 4 3 |
Posterior Chamber, Inflammation, | |
Chronic | 3 3 3 3 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Multifocal | 1 |
__________________________________________________________________________|
Zymbal's Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + +|
Nephropathy, Multifocal | 1 1 |
Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| |
| 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large | + + A + A + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + A + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + A + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + A + A + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + A + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + A + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + A + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 33 |
Cyst | X | 1 |
Eosinophilic Focus | | 3 |
Mixed Cell Focus | X | 1 |
Necrosis, Coagulative, Multifocal | | 1 1.0|
Necrosis, Caseous, Multifocal | | 1 1.0|
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1| 22 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + A + A + | 10 |
Acinus, Atrophy | 1 3 | 5 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + A + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + A + | 11 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 13 |
Myocardium, Degeneration, Multifocal | 1 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 13 |
Hyperplasia, Nodular | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 13 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| |
| 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + +| 32 |
Angiectasis, Focal | 1| 1 1.0|
Autolysis | | 1 3.0|
Pars Distalis, Angiectasis, Focal | 1 | 2 1.5|
Pars Distalis, Cyst | X X X X | 6 |
Pars Distalis, Hyperplasia, Nodular | 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + A + A + | 9 |
C-Cell, Hyperplasia | 2 2 3 | 8 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + | 14 |
Inflammation, Chronic | 1 1 | 4 1.0|
Duct, Dilatation | 3 | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 19 |
Inflammation, Chronic | 2 | 1 2.0|
Periovarian Tissue, Cyst | X X X | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 25 |
Dilatation | 3 | 3 2.7|
Endometrium, Hyperplasia, Cystic | 4 2 2 2 | 5 2.6|
Wall, Cyst | X | 1 |
__________________________________________________________________________|____________|
Vagina | + | 2 |
Cyst | 4 | 1 4.0|
Lumen, Exudate | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 12 |
Femoral, Hyperplasia | 2 3 | 4 2.3|
Femoral, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + A + + + + + | 17 |
Autolysis | | 1 3.0|
Fibrosis, Diffuse | | 1 4.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Capsule, Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| |
| 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 19 |
Hyperplasia, Cystic | 1 3 | 6 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 13 |
Femur, Osteopetrosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 13 |
Hypothalamus, Compression | 3 4 | 4 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 13 |
Alveolus, Inflammation, Multifocal, | | |
Suppurative | 3 | 1 3.0|
Bronchus, Foreign Body | 3 | 1 3.0|
Bronchus, Inflammation, Multifocal, | | |
Suppurative | 3 | 1 3.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Cornea, Inflammation, Suppurative | 3 | 1 3.0|
Lens Crystalline, Cataract | 3 4 | 6 3.2|
Posterior Chamber, Inflammation, | | |
Chronic | | 4 3.0|
Retina, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 5| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 0| 0| 4| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| |
| 9| 9| 8| 2| 2| 6| 2| 6| 6| 6| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 9| 9| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + | 13 |
Nephropathy, Multifocal | 3 3 2 | 5 2.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|
| 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Fatty Change | |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | |
Necrosis, Caseous, Multifocal | 1 |
Centrilobular, Cytomegaly | 2 1 1 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + +|
Acinus, Atrophy | 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + +|
Ectopic Tissue | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Acanthosis, Diffuse | |
Epithelium, Hyperkeratosis, Diffuse | |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + A + + + +|
Inflammation, Chronic | |
Mucosa, Inflammation, Multifocal, | |
Necrotizing | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + +|
Myocardium, Degeneration, Diffuse | |
Myocardium, Degeneration, Multifocal | 1 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + A + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + A + + + +|
Hyperplasia, Nodular | 1 3 2 2 1 1|
Hypertrophy, Multifocal | |
Necrosis, Coagulative | 4 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|
| 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + A + + + +|
Hyperplasia, Nodular | 1 1 1 1|
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M|
Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Pituitary Gland | A + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 4 1 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Nodular | 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | A + + + + + A + + + +|
Cyst | X|
C-Cell, Hyperplasia | 2 2 2 3 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M|
Inflammation, Chronic | |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | X |
Periovarian Tissue, Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hemorrhage | |
Cervix, Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 3 2 3|
Endometrium, Hyperplasia, Nodular | 2 |
Lumen, Hemorrhage | 4 |
__________________________________________________________________________|
Vagina | + + + |
Cyst | 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + +|
Femoral, Hyperplasia | 1 2 3 2 1 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Mandibular, Hemorrhage, Focal | |
Sinus, Mandibular, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + +|
Sinus, Ectasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|
| 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 3 1 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Tail, Acanthosis, Focal | 3 |
Tail, Hyperkeratosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Hypothalamus, Compression | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Congestion | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
Nares, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
Anterior, Synechia | 2 |
Lens Crystalline, Cataract | 4 |
Posterior Chamber, Inflammation, | |
Chronic | 3 3 |
Retina, Atrophy | 3 |
Sclera, Mineralization, Multifocal | 2 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + +|
Nephropathy, Multifocal | 1 1 1 2 |
Glomerulus, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 6|
DAY ON TEST | 9| 2| 6| 2| 2| 9| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 7| 3| 3| 0| 5| 3| 1| 3| 0|
| 0| 9| 2| 9| 9| 9| 6| 0| 0| 0| 1| 1| 0| 7| 1| 2| 6| 2| 2| 2| 9| 2| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Membranoproliferative | 3 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3| |
| 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 35 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 1 |
Fatty Change | 3 | 1 3.0|
Necrosis, Coagulative, Focal | 1 | 1 1.0|
Necrosis, Coagulative, Multifocal | 2 | 1 2.0|
Necrosis, Caseous, Multifocal | | 1 1.0|
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 | 24 1.1|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 21 |
Acinus, Atrophy | 1 2 | 5 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 22 |
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + | 22 |
Inflammation, Chronic | 3 | 1 3.0|
Epithelium, Acanthosis, Diffuse | 2 | 1 2.0|
Epithelium, Hyperkeratosis, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + | 20 |
Inflammation, Chronic | 3 | 1 3.0|
Mucosa, Inflammation, Multifocal, | | |
Necrotizing | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 22 |
Myocardium, Degeneration, Diffuse | 1 | 1 1.0|
Myocardium, Degeneration, Multifocal | 1 1 2 1 | 8 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3| |
| 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 20 |
Hyperplasia, Nodular | 2 2 2 | 9 1.8|
Hypertrophy, Multifocal | 2 | 1 2.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + | 22 |
Hyperplasia, Nodular | 1 1 1 | 7 1.0|
Necrosis, Coagulative | | 1 4.0|
Vacuolization Cytoplasmic, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + M + | 19 |
Hyperplasia, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + +| 35 |
Pars Distalis, Angiectasis, Focal | 2 | 4 2.3|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia, Nodular | 2 2 1 | 6 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 20 |
Cyst | | 1 |
C-Cell, Hyperplasia | 3 2 2 2 2 4 2 2 2 | 16 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + | 24 |
Inflammation, Chronic | 1 1 | 2 1.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + | 26 |
Bilateral, Periovarian Tissue, Cyst | | 1 |
Periovarian Tissue, Cyst | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 35 |
Dilatation | 4 | 2 3.0|
Hemorrhage | 3 | 1 3.0|
Cervix, Inflammation, Suppurative | 4 | 2 3.0|
Endometrium, Hyperplasia, Cystic | 2 1 1 | 6 2.0|
Endometrium, Hyperplasia, Nodular | | 1 2.0|
Lumen, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + | 4 |
Cyst | 3 | 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3| |
| 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 22 |
Femoral, Hyperplasia | 3 2 4 3 2 3 1 | 14 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 23 |
Mandibular, Hemorrhage, Focal | 1 | 1 1.0|
Sinus, Mandibular, Ectasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 6 |
Sinus, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 22 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + | 25 |
Hyperplasia, Cystic | 4 1 3 3 4 3 | 15 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 26 |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 4 | 1 4.0|
Tail, Acanthosis, Focal | | 1 3.0|
Tail, Hyperkeratosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 22 |
Hypothalamus, Compression | 4 2 | 4 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 23 |
Congestion | 1 | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 22 |
Nares, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| |
DAY ON TEST | 3| 7| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 1| 0| 3| 3| 3| 3| 1| 9| 3| 3| 3| |
| 6| 1| 6| 6| 6| 7| 7| 7| 7| 0| 9| 9| 8| 8| 8| 6| 8| 5| 9| 9| 2| 0| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Anterior, Synechia | | 1 2.0|
Lens Crystalline, Cataract | 4 4 1 | 4 3.3|
Posterior Chamber, Inflammation, | | |
Chronic | 3 3 1 | 5 2.6|
Retina, Atrophy | | 1 3.0|
Sclera, Mineralization, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 22 |
Nephropathy, Multifocal | 4 2 1 1 1 | 9 1.6|
Glomerulus, Inflammation, | | |
Membranoproliferative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|
| 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change | 3 |
Mixed Cell Focus | |
Necrosis, Coagulative, Multifocal | 2 |
Regeneration, Focal | 3 |
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + |
Acinus, Atrophy | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
Parotid Gland, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + |
Edema | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + |
__________________________________________________________________________|
Tongue | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Coronary Artery, Inflammation, | |
Chronic | |
Myocardium, Degeneration, Multifocal | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Atrophy | 3 |
Hyperplasia, Nodular | 3 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|
| 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
Hyperplasia, Nodular | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis, Focal | 3 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia, Nodular | 2 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + |
C-Cell, Hyperplasia | 3 2 2 3 3 1 1 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Duct, Dilatation | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + |
Periovarian Tissue, Cyst | X X X |
Periovarian Tissue, Necrosis, Caseous| 1 |
Vein, Congestion | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + |
Dilatation | |
Hyperplasia, Cystic | |
Cervix, Inflammation, Suppurative | 2 3 3 |
Endometrium, Hyperplasia, Cystic | 3 |
Endometrium, Necrosis, Coagulative | |
__________________________________________________________________________|
Vagina | + + + + + |
Cyst | 3 4 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Femoral, Hyperplasia | 2 1 2 2 3 2 |
Femoral, Myelofibrosis | 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mandibular, Infiltration Cellular, | |
Polymorphonuclear | 2 |
Renal, Necrosis, Caseous | 2 |
Sinus, Mandibular, Ectasia | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Sinus, Ectasia | 3 4 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 7| 3| 2| 3| 5| 3| 3| 3| 8| 3| 0| 9| 3| 0| 5| 3| 1| 0| 3| 3| 3|
| 9| 9| 9| 9| 3| 9| 9| 0| 8| 0| 0| 0| 6| 1| 0| 1| 1| 4| 9| 1| 6| 4| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + |
Hyperplasia, Cystic | 2 2 3 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Hypothalamus, Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Alveolus, Hemorrhage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Eye | + + + + + |
Bilateral, Lens Crystalline, Cataract| |
Lens Crystalline, Cataract | 4 4 2 4 2 |
Posterior Chamber, Inflammation, | |
Chronic | 2 2 3 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Nephropathy, Multifocal | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + |
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| |
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3| |
| 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 16 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A | 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X | 31 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X | 1 |
Fatty Change | 4 | 2 3.5|
Mixed Cell Focus | X X | 2 |
Necrosis, Coagulative, Multifocal | | 1 2.0|
Regeneration, Focal | | 1 3.0|
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 16 |
Acinus, Atrophy | 1 3 | 5 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 17 |
Parotid Gland, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 16 |
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 16 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 17 |
Coronary Artery, Inflammation, | | |
Chronic | 2 | 1 2.0|
Myocardium, Degeneration, Multifocal | 1 2 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| |
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3| |
| 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 17 |
Atrophy | | 1 3.0|
Hyperplasia, Nodular | 2 2 1 2 | 5 2.0|
Hypertrophy, Focal | 1 | 2 1.5|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 17 |
Hyperplasia, Nodular | 1 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 33 |
Pars Distalis, Angiectasis, Focal | 2 2 2 4 | 6 2.5|
Pars Distalis, Cyst | X X | 5 |
Pars Distalis, Hyperplasia, Nodular | | 2 1.5|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + +| 17 |
C-Cell, Hyperplasia | 2 2 2 4 3 3 1 | 16 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 20 |
Inflammation, Chronic | 1 1 1 1 | 4 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Duct, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 21 |
Periovarian Tissue, Cyst | X X | 5 |
Periovarian Tissue, Necrosis, Caseous| | 1 1.0|
Vein, Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + +| 31 |
Dilatation | 3 | 1 3.0|
Hyperplasia, Cystic | 3 | 1 3.0|
Cervix, Inflammation, Suppurative | 3 2| 5 2.6|
Endometrium, Hyperplasia, Cystic | 3 | 2 3.0|
Endometrium, Necrosis, Coagulative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Vagina | + +| 7 |
Cyst | 3 2| 7 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| |
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3| |
| 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 17 |
Femoral, Hyperplasia | 2 3 | 8 2.1|
Femoral, Myelofibrosis | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 22 |
Mandibular, Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Renal, Necrosis, Caseous | | 1 2.0|
Sinus, Mandibular, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | +| 6 |
Sinus, Ectasia | | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + +| 21 |
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M| 17 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 23 |
Hyperplasia, Cystic | 3 4 4 4 2 2 | 12 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 18 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 17 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 17 |
Hypothalamus, Compression | 4 4 4 4 | 5 3.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + +| 18 |
Alveolus, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 17 |
Inflammation, Subacute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Middle Ear, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 5| 7| 7| |
DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 4| 3| 3| 3| 9| 9| 7| 3| 3| |
| 2| 8| 2| 7| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 5| 8| 8| 8| 9| 9| 2| 5| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + + +| 9 |
Bilateral, Lens Crystalline, Cataract| 3 | 1 3.0|
Lens Crystalline, Cataract | 1 3 4| 8 3.0|
Posterior Chamber, Inflammation, | | |
Chronic | 2 3 3 | 8 2.6|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 17 |
Nephropathy, Multifocal | 2 2 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 16 |
Ectasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + M|
Inflammation, Chronic Active, Focal | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Mixed Cell Focus | X |
Necrosis, Coagulative, Multifocal | |
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Sinusoid, Angiectasis | 4 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Parotid Gland, Atrophy | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Proliferation, Focal | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 2 |
Gingiva, Inflammation, Chronic Active| |
Gingiva, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium Left, Thrombosis | X |
Coronary Artery, Inflammation, | |
Chronic | 1 |
Endocardium, Proliferation | |
Epicardium, Inflammation, Chronic | |
Myocardium, Degeneration, Multifocal | 1 3 2 2 1 1 1 1 1 1 1 1 1 1|
Myocardium, Fibrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 1 2 1 1 1 1 1 1 2 1 1|
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 1 2 1 3 1 2 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Pars Distalis, Angiectasis, Focal | 3 |
Pars Distalis, Hyperplasia, Nodular | 1 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 3 2 3 3 1 2 2 1 3 1 2 1 2 2 1 2 3 2|
Follicle, Dilatation, Focal | 1 |
Follicle, Dilatation, Multifocal | 2 1 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prolapse | |
Endometrium, Hyperplasia, Cystic | 2 3 2 |
Endometrium, Necrosis, Coagulative | 4 |
Wall, Inflammation, Chronic Active | |
__________________________________________________________________________|
Vagina | + |
Cyst | 4 |
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sinus, Mandibular, Ectasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | M + M M + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 3 1 1 2 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis, Focal | 1 |
Infarct | |
Hypothalamus, Compression | 3 4 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Hemorrhage | 2 |
Artery, Mineralization | 1 |
Interstitium, Inflammation, Chronic, | |
Multifocal | 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
Anterior Chamber, Inflammation, | |
Suppurative | 4 |
Lens Crystalline, Cataract | 3 4 3 4 2 |
Posterior Chamber, Inflammation, | |
Chronic | 3 2 |
Retina, Atrophy | 4 3 4 4 4 |
Sclera, Mineralization, Multifocal | |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Inflammation, Chronic, Multifocal | 1 1 1 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 3| 7| 3| 3| 3| 3| 3| 0| 3| 8| 3| 3| 3| 7| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 0| 0| 0| 1| 0| 0| 1| 1| 1| 0| 1| 3| 1| 0| 2| 5| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Multifocal | 1 1 1 1 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3| |
| 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 6 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X | 5 |
Mixed Cell Focus | | 1 |
Necrosis, Coagulative, Multifocal | 1 | 1 1.0|
Centrilobular, Cytomegaly | 1 1 2 1 1 2 1 1 1 2 1 1 1 2 1 1 1 1 1 1| 42 1.1|
Sinusoid, Angiectasis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 2 1 1 1 1 4 1 3 1 | 22 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Acinus, Parotid Gland, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Proliferation, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Dysplasia | | 1 2.0|
Gingiva, Inflammation, Chronic Active| 4 | 1 4.0|
Gingiva, Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium Left, Thrombosis | | 1 |
Coronary Artery, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3| |
| 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Chronic | | 1 1.0|
Endocardium, Proliferation | 2 | 1 2.0|
Epicardium, Inflammation, Chronic | 1 1 | 2 1.0|
Myocardium, Degeneration, Multifocal | 1 2 1 1 1 1 1 1 1 1 2 1 1| 27 1.2|
Myocardium, Fibrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 1 1 1 1 2 2 2 2 2 2| 22 1.4|
Hypertrophy, Focal | 1 1 | 2 1.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 1 2 1 1 1 1 1 1 | 18 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + M + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 1 2.0|
Pars Distalis, Angiectasis, Focal | 2 3 | 3 2.7|
Pars Distalis, Hyperplasia, Nodular | 1 2 2 3 3 2| 10 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 3 2 1 2 2 1 2 3 3 1 3 3 2 2 3 1 2 2 3 2 2| 43 2.1|
Follicle, Dilatation, Focal | 1| 2 1.0|
Follicle, Dilatation, Multifocal | | 2 1.5|
Follicular Cell, Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
Inflammation, Chronic | 2 1 1 1 1| 7 1.1|
Inflammation, Chronic Active | 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prolapse | X | 1 |
Endometrium, Hyperplasia, Cystic | 3 1 4 | 6 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3| |
| 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Necrosis, Coagulative | 4 | 2 4.0|
Wall, Inflammation, Chronic Active | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Vagina | + | 2 |
Cyst | | 1 4.0|
Prolapse | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | 3 3 2 3 1 | 8 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Sinus, Mandibular, Ectasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 4 |
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 1 1 3 2 2 2 3 | 16 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis, Focal | | 1 1.0|
Infarct | 4 | 1 4.0|
Hypothalamus, Compression | 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolus, Hemorrhage | 1 | 2 1.5|
Artery, Mineralization | | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 0| 2| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 9| 9| 3| 3| 3| 3| 3| |
| 6| 6| 6| 6| 3| 6| 7| 3| 7| 7| 7| 3| 7| 7| 8| 0| 8| 8| 9| 9| 8| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 4.0|
Lens Crystalline, Cataract | 3 | 6 3.2|
Posterior Chamber, Inflammation, | | |
Chronic | | 2 2.5|
Retina, Atrophy | 4 | 6 3.8|
Sclera, Mineralization, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 7 |
Inflammation, Chronic, Multifocal | 1 | 5 1.2|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Multifocal | 1 1 1 1 1 1 1 1 | 15 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 2 1.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | 2| 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|
| 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic, Focal | 1 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X |
Regeneration, Focal | |
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Acinus, Atrophy | 2 1 1 2 |
Acinus, Hypertrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Gingiva, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium Left, Thrombosis | X |
Coronary Artery, Inflammation, | |
Chronic | |
Epicardium, Inflammation, Chronic | 1 |
Myocardium, Degeneration, Multifocal | 1 1 2 3 1 1 1 1 2 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
Valve, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|
| 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 2 2 3 1 1 |
Mineralization, Focal | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 3 2 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 3 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 2 2 1 2 2 1 2 1 2 1 2 3 2|
Follicle, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 2 1 |
Inflammation, Chronic Active | 2 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Prolapse | X |
Endometrium, Hyperplasia, Cystic | 1 2 4 |
Endometrium, Necrosis, Coagulative | |
Wall, Bacterium | X |
Wall, Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Vagina | + +|
Cyst | 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|
| 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 2 2 1 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 2 |
Artery, Mineralization | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Inflammation, Chronic| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Canal, External Ear, Exudate, | |
Subacute | 2 |
Middle Ear, Inflammation, Chronic | |
Middle Ear, Inflammation, Chronic | |
Active | |
Middle Ear, Inflammation, Subacute | |
__________________________________________________________________________|
Eye | + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 1| 1| 1| 1| 1| 7| 7| 7| 3| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 2| 2| 3| 2| 2| 2| 2| 2| 1| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 9| 3| 4| 3|
| 0| 9| 9| 9| 0| 8| 8| 8| 8| 8| 4| 0| 0| 5| 0| 2| 1| 1| 1| 1| 2| 3| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens Crystalline, Cataract | 1 3|
Retina, Atrophy | 4|
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Multifocal, Necrotizing| 4 |
Nephropathy, Multifocal | 1 1 1 1 1 1 1|
Pelvis, Renal Tubule, Bacterium | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Transitional Epithelium, Hyperplasia,| |
Diffuse | 4 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8| |
| 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 3 |
Clear Cell Focus | X X | 3 |
Eosinophilic Focus | X X | 2 |
Hepatodiaphragmatic Nodule | | 2 |
Mixed Cell Focus | X X X | 4 |
Regeneration, Focal | 2 | 1 2.0|
Centrilobular, Cytomegaly | 1 1 1 1 1 2 1 1 1 2 1 1 1 1 2 1 1 1 1 1 | 38 1.1|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Tissue | X | 1 |
Acinus, Atrophy | 1 1 2 1 3 1 1 2 1 1 | 14 1.4|
Acinus, Hypertrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 3| 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Gingiva, Inflammation, Chronic Active| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium Left, Thrombosis | | 1 |
Coronary Artery, Inflammation, | | |
Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8| |
| 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Epicardium, Inflammation, Chronic | 1 | 2 1.0|
Myocardium, Degeneration, Multifocal | 1 1 1 1 2 1 1 1 1 1 2| 20 1.3|
Myocardium, Inflammation, Chronic, | | |
Multifocal | 1 1 1 1 | 5 1.0|
Valve, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 1 3 1 1 1 1 1 2 2 | 15 1.6|
Mineralization, Focal | 1 | 1 1.0|
Vacuolization Cytoplasmic, Focal | 1| 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 2 2 2 1| 15 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | | 2 3.0|
Pars Distalis, Cyst | X X X | 4 |
Pars Distalis, Hyperplasia, Nodular | 1 | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 3 4 2 1 2 2 1 2 1 3 1 3 2 1 2 2 1 1 1 2 2 2| 39 1.8|
Follicle, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 | 9 1.1|
Inflammation, Chronic Active | | 1 2.0|
Duct, Dilatation | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 3| 2 2.0|
Follicle, Cyst | | 1 |
Periovarian Tissue, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Prolapse | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8| |
| 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 4 2 3 2 2 3 4 | 10 2.7|
Endometrium, Necrosis, Coagulative | 4 | 1 4.0|
Wall, Bacterium | | 1 |
Wall, Inflammation, Chronic Active | 4 | 3 3.0|
__________________________________________________________________________|____________|
Vagina | + | 3 |
Cyst | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | 2 2 3 2 3 1 | 9 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 3 |
Sinus, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 1 2 1 2 2 2 1 1 2 3 2 2 2 3| 21 1.9|
Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypothalamus, Compression | 4 4| 2 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 3 1.7|
Artery, Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 5| |
DAY ON TEST | 3| 4| 3| 3| 1| 3| 9| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 8| |
| 2| 4| 6| 6| 1| 6| 3| 6| 7| 7| 1| 7| 7| 8| 8| 2| 8| 8| 9| 9| 1| 0| 9| 9| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lamina Propria, Inflammation, Chronic| 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + +| 4 |
Canal, External Ear, Exudate, | | |
Subacute | | 1 2.0|
Middle Ear, Inflammation, Chronic | 2 | 1 2.0|
Middle Ear, Inflammation, Chronic | | |
Active | 2| 1 2.0|
Middle Ear, Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + | 4 |
Lens Crystalline, Cataract | 4 4 | 4 3.0|
Retina, Atrophy | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Inflammation, Chronic, Multifocal | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 | 1 2.0|
Inflammation, Multifocal, Necrotizing| | 1 4.0|
Nephropathy, Multifocal | 1 1 1 1 1 1 1 2 | 15 1.1|
Pelvis, Renal Tubule, Bacterium | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 2.0|
Transitional Epithelium, Hyperplasia,| | |
Diffuse | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|
| 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Arteriole, Inflammation, Chronic | 3 |
Arteriole, Thrombosis | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + A|
Ulcer | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 X X X X X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | X X X |
Fatty Change | 2 1 |
Mixed Cell Focus | X |
Necrosis, Coagulative, Multifocal | 1 1 2 |
Necrosis, Caseous, Focal | 1 |
Sinusoid, Angiectasis | |
Sinusoid, Angiectasis, Multifocal | 2 |
__________________________________________________________________________|
Mesentery | + +|
Inflammation, Chronic | 1 |
Fat, Necrosis | 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 3 1 1 3 3 1 1 1 2 1 2|
Artery, Inflammation, Chronic | 4 |
Duct, Concretion | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Submandibular Gland, Atrophy | 1 |
Parotid Gland, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Ulcer | 1 |
Arteriole, Submucosa, Thrombosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|
| 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium Left, Thrombosis | X |
Myocardium, Degeneration, Multifocal | 1 1 2 3 3 3 3 3 2 2 3 3 3 1 2 1 2 2 2 3 2|
Myocardium, Fibrosis, Focal | 2 |
Myocardium, Inflammation, Chronic, | |
Focal | |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
Myocardium, Inflammation, Multifocal,| |
Necrotizing | |
Valve, Bacterium | X |
Valve, Inflammation, Chronic Active | 3 |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 3 1 2 3 2 2 1 4 3 1 1 |
Hypertrophy, Focal | 2 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 1 2 1 2 1 4 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Diffuse | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
Pars Distalis, Hyperplasia, Nodular | 1 1 |
Pars Nervosa, Inflammation, | |
Multifocal, Subacute | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Necrosis, Caseous, Focal | |
C-Cell, Hyperplasia | 3 2 2 3 3 3 2 4 3 3 4 4 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|
| 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Chronic | 3 2 2 2 3 3 1 1 1 1 1|
Inflammation, Chronic Active | 1 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Hemorrhage | |
__________________________________________________________________________|
Seminal Vesicle | + + |
Hemorrhage | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 1 |
Necrosis | |
Artery, Inflammation, Chronic | 2 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 3 3 2 2 3 2 2 3 1 1|
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hematopoietic Cell | |
Proliferation | 1 |
Mediastinal, Medulla, Fibrosis | 2 |
Mediastinal, Sinus, Ectasia | |
Sinus, Mandibular, Ectasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 2 |
Hematopoietic Cell Proliferation | 4 |
Capsule, Pigmentation, Focal, | |
Hemosiderin | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + M + M M M + + +|
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + |
Granuloma | 1 |
Hyperplasia, Cystic | 3 3 2 2 2 3 2 3 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 4| 3| 3| 3| 8| 3| 5| 3| 0| 6| 3| 1| 3| 1| 3| 1| 3| 9| 3| 3| 3| 4|
| 2| 2| 3| 5| 2| 3| 3| 8| 3| 5| 2| 1| 1| 4| 6| 4| 7| 4| 6| 5| 5| 5| 5| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
Hindlimb, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Mineralization, Focal | |
Hypothalamus, Compression | 1 3 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Mineralization | 1 1 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 |
Interstitium, Inflammation, Chronic, | |
Multifocal | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
External Ear, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Eye | + + |
Anterior Chamber, Hemorrhage | |
Lens Crystalline, Cataract | 4 1 |
Posterior Chamber, Inflammation, | |
Chronic | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Multifocal | 1 1 2 4 2 3 3 2 3 2 4 3 1 3 1 3 2 2 4 2 1 3 2 3 1|
Renal Tubule, Cytoplasmic Alteration | 2 |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Arteriole, Inflammation, Chronic | | 1 3.0|
Arteriole, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + +| 46 |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X | 17 1.0|
Clear Cell Focus | X X | 2 |
Degeneration, Cystic | 1 2 1 1 | 6 1.3|
Eosinophilic Focus | X X | 5 |
Fatty Change | 1 | 3 1.3|
Mixed Cell Focus | X | 2 |
Necrosis, Coagulative, Multifocal | 3 | 4 1.8|
Necrosis, Caseous, Focal | | 1 1.0|
Sinusoid, Angiectasis | 2 | 1 2.0|
Sinusoid, Angiectasis, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 7 |
Inflammation, Chronic | 2 | 2 1.5|
Fat, Necrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 1 1 3 3 2 4 3 1 1 1 1 | 27 1.7|
Artery, Inflammation, Chronic | | 1 4.0|
Duct, Concretion | 4 | 1 4.0|
Duct, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Submandibular Gland, Atrophy | | 1 1.0|
Parotid Gland, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ulcer | 3 2 | 3 2.0|
Arteriole, Submucosa, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium Left, Thrombosis | | 1 |
Myocardium, Degeneration, Multifocal | 2 2 2 1 1 3 4 4 1 3 2 2 2 2 1 1 2 1 | 39 2.1|
Myocardium, Fibrosis, Focal | | 1 2.0|
Myocardium, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Myocardium, Inflammation, Multifocal,| | |
Necrotizing | 3 | 1 3.0|
Valve, Bacterium | X | 2 |
Valve, Inflammation, Chronic Active | 4 | 2 3.5|
Valve, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 1 2 2 2 1 1 1 1 1| 20 1.8|
Hypertrophy, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 1 3 2 1 1 | 14 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Diffuse | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | | 1 2.0|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Nodular | 1 4 2 1| 6 1.7|
Pars Nervosa, Inflammation, | | |
Multifocal, Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Necrosis, Caseous, Focal | 1 | 1 1.0|
C-Cell, Hyperplasia | 2 1 3 3 3 3 2 2 3 2 2 2 3 2 2 2 3 2 3 2 1 1 2| 37 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Granuloma Sperm | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 2 2 1 2 1 2 1 1 2 1 1 2 1 2 1 1 1| 28 1.6|
Inflammation, Chronic Active | 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma | 4 | 1 4.0|
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 1.0|
Necrosis | 4 4 | 2 4.0|
Artery, Inflammation, Chronic | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 | 1 1.0|
Seminiferous Tubule, Atrophy | 4 4 | 4 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | 3 3 4 2 2 4 3 2 1 1 2 | 21 2.3|
Femoral, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 1.0|
Mediastinal, Medulla, Fibrosis | | 1 2.0|
Mediastinal, Sinus, Ectasia | 3 | 1 3.0|
Sinus, Mandibular, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 5 |
Sinus, Ectasia | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis, Focal | | 2 2.0|
Hematopoietic Cell Proliferation | 2 1 | 3 2.3|
Capsule, Pigmentation, Focal, | | |
Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + M + + + + + + M + M + + + + + + + M| 40 |
Ectopic Parathyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + +| 23 |
Granuloma | | 1 1.0|
Hyperplasia, Cystic | 2 1 2 1 1 2 2 1 1| 20 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic | | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femur, Fibrous Osteodystrophy | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Hindlimb, Inflammation, Subacute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 3 2 | 2 2.5|
Mineralization, Focal | 1 | 1 1.0|
Hypothalamus, Compression | 1 3 1 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Mineralization | | 2 1.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 1 | 2 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 4| 7| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 6| 7| 6| 6| 7| 6| 7| |
DAY ON TEST | 3| 5| 3| 4| 3| 1| 4| 5| 4| 4| 8| 1| 4| 5| 4| 4| 4| 2| 6| 4| 3| 1| 4| 9| 4| |
| 9| 9| 9| 3| 7| 6| 0| 9| 0| 1| 3| 1| 1| 8| 1| 1| 2| 3| 7| 2| 4| 7| 2| 0| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
External Ear, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + + + + + + | 9 |
Anterior Chamber, Hemorrhage | 4 | 1 4.0|
Lens Crystalline, Cataract | 1 2 3 3 4 3 2 | 9 2.6|
Posterior Chamber, Inflammation, | | |
Chronic | | 1 3.0|
Retina, Atrophy | 4 4 4 4 4 4 | 7 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Multifocal | 3 1 2 1 3 1 2 1 2 2 1 3 3 1 3 2 3 1 1 1 1 1 2 1 2| 50 2.0|
Renal Tubule, Cytoplasmic Alteration | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|
| 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + A + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 1 |
Eosinophilic Focus | X |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 2 2 2 |
Centrilobular, Necrosis, Coagulative | 2 |
Periportal, Vacuolization Cytoplasmic| 2 |
Sinusoid, Angiectasis, Focal | 1 |
Sinusoid, Angiectasis | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + +|
Autolysis | 3 |
Acinus, Atrophy | 2 2 1 2 2 3 1|
Duct, Ectasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + +|
Acinus, Submandibular Gland, Atrophy | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + +|
Edema | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + A + + + + +|
Edema | |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|
| 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium Left, Thrombosis | X |
Myocardium, Degeneration, Multifocal | 2 2 2 1 2 2 2 2 1 3 2 2 3 3|
Myocardium, Mineralization, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 1 2 3 1 2|
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Hyperplasia, Nodular | 2 3 1 2 1 3 1 2 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + A + A + + + A + + + + + +|
C-Cell, Hyperplasia | 3 1 3 2 2 1|
Follicle, Dilatation, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 3 2 2 1 1 1 1 2 1 1|
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 |
Seminiferous Tubule, Atrophy | 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + +|
Femoral, Hyperplasia | 4 3 2 2 2 3 3 3 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Lumbar, Sinus, Ectasia | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|
| 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 4 |
Capsule, Fibrosis, Focal | |
Red Pulp, Pigmentation, Diffuse, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M +|
Mediastinum, Inflammation, Chronic, | |
Multifocal | 2 |
Vein, Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + |
Hyperplasia, Cystic | 3 1 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Inflammation, Necrotizing | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Cranium, Inflammation, Chronic, Focal| 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infarct | |
Hypothalamus, Compression | 4 |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
Congestion | 3 3 |
Alveolus, Hemorrhage | 3 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 6|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 1| 3| 3| 3| 1| 7| 6| 3| 4| 3| 8| 3| 3| 3| 3| 2| 7| 6| 5|
| 2| 2| 2| 2| 3| 2| 5| 3| 0| 3| 3| 0| 9| 3| 4| 4| 8| 4| 4| 5| 5| 7| 9| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Pinna, Inflammation, Necrotizing | |
__________________________________________________________________________|
Eye | + |
Lens Crystalline, Cataract | 3 |
Posterior Chamber, Inflammation, | |
Chronic | |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + +|
Infarct | |
Nephropathy, Multifocal | 3 3 3 2 1 1 1 1 1 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6| |
| 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + A + + +| 22 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + +| 24 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + +| 24 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + +| 25 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + A + + +| 22 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + +| 24 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X| 17 |
Clear Cell Focus | X X X | 5 |
Degeneration, Cystic | 2 1 | 5 1.2|
Eosinophilic Focus | X | 2 |
Fatty Change | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Necrosis, Coagulative, Focal | 1 | 1 1.0|
Necrosis, Coagulative, Multifocal | 2 1 | 5 1.8|
Centrilobular, Necrosis, Coagulative | | 1 2.0|
Periportal, Vacuolization Cytoplasmic| | 1 2.0|
Sinusoid, Angiectasis, Focal | | 1 1.0|
Sinusoid, Angiectasis | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + +| 27 |
Autolysis | | 1 3.0|
Acinus, Atrophy | 1 1 2 2 1 1 2 | 14 1.6|
Duct, Ectasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + +| 27 |
Acinus, Submandibular Gland, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + +| 26 |
Edema | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + +| 25 |
Edema | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6| |
| 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Peridontal Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + +| 28 |
Atrium Left, Thrombosis | | 1 |
Myocardium, Degeneration, Multifocal | 2 3 1 3 1 1 3 3| 22 2.1|
Myocardium, Mineralization, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 1 1 2 4 | 10 1.8|
Hypertrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
Hyperplasia, Nodular | 2 1 3 1 1 3 1 1 1 3 1 1 1 1 1| 25 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +| 34 |
Pars Distalis, Angiectasis, Focal | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Nodular | 2| 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + +| 26 |
C-Cell, Hyperplasia | 2 2 3 2 2 1 2 | 13 2.0|
Follicle, Dilatation, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + +| 27 |
Hyperplasia | 4 | 1 4.0|
Inflammation, Chronic | 2 1 1 1 1 1 2 1| 18 1.4|
Inflammation, Chronic Active | 1 3 3 | 5 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6| |
| 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | | 1 3.0|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 | 9 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + +| 26 |
Femoral, Hyperplasia | 2 2 2 2 2 3 4 2 2 2| 20 2.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 27 |
Lumbar, Sinus, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 7 |
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + +| 33 |
Fibrosis, Focal | 3 | 2 3.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Capsule, Fibrosis, Focal | 3 | 1 3.0|
Red Pulp, Pigmentation, Diffuse, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + M + + +| 23 |
Mediastinum, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Vein, Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 12 |
Hyperplasia, Cystic | 3 3 3 4 4 1 | 11 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + +| 29 |
Hyperkeratosis | | 1 1.0|
Inflammation, Necrotizing | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + +| 27 |
Cranium, Inflammation, Chronic, Focal| | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + +| 27 |
Hemorrhage | | 1 1.0|
Infarct | 4 4 4 3 | 4 3.8|
Hypothalamus, Compression | 1 4 3 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 9| 4| 3| 3| 3| 1| 8| 4| 4| 4| 4| 1| 4| 1| 4| 1| 5| 7| 4| 4| 6| 1| 6| |
| 5| 9| 7| 6| 9| 9| 6| 4| 7| 0| 0| 1| 1| 9| 1| 8| 2| 8| 1| 3| 2| 2| 6| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + +| 27 |
Congestion | | 2 3.0|
Alveolus, Hemorrhage | | 1 3.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 2 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Pinna, Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Eye | + + | 3 |
Lens Crystalline, Cataract | 4 | 2 3.5|
Posterior Chamber, Inflammation, | | |
Chronic | 4 3 | 2 3.5|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + +| 28 |
Infarct | 3 | 1 3.0|
Nephropathy, Multifocal | 1 1 1 2 2 3 3 3 1 1 1 1 2| 26 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + +| 26 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|
DAY ON TEST | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|
| 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + A + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + + A A|
__________________________________________________________________________|
Intestine Large, Colon | A + M + + A + + + A +|
Diverticulum | |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + A A|
__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X |
Degeneration, Cystic | 2 1 1 1 |
Eosinophilic Focus | X X X |
Fatty Change | |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | |
Regeneration, Focal | |
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 |
Centrilobular, Necrosis, Coagulative | 3 |
Sinusoid, Angiectasis, Focal | 1 |
Sinusoid, Angiectasis | 1 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + A +|
Acinus, Atrophy | 3 2 3 1 2 |
Acinus, Hypertrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | A + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Stomach | A + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + +|
Dilatation | |
Atrium, Dilatation | 3 4 |
Atrium Left, Thrombosis | X |
Myocardium, Degeneration, Multifocal | 2 3 2 2 2 2 2 2|
Myocardium, Inflammation, Chronic, | |
Focal | 2 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|
DAY ON TEST | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|
| 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 3 1 1 2 4 2 |
Hypertrophy, Focal | 1 |
Mineralization, Multifocal | |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 1 2 1 1 2 2 3 2 1 2 2 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + +|
Pars Distalis, Hyperplasia, Nodular | |
__________________________________________________________________________|
Thyroid Gland | + A + + + + A + + + A A|
C-Cell, Hyperplasia | 2 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 2 1 3 2 1 2 1 2 3|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A +|
Femoral, Hyperplasia | 4 3 2 3 3 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Sinus, Ectasia | |
Sinus, Mandibular, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Sinus, Ectasia | 1 |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|
DAY ON TEST | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|
| 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis, Focal | 1 3 3 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Hyperplasia, Cystic | 3 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | |
Inflammation, Granulomatous | 3 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + +|
Tibia, Fracture Healed | X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Infarct | 1 |
Hypothalamus, Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Bacterium | X |
Congestion | 3 2 |
Alveolus, Hemorrhage | 3 2 1 1 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Anterior, Synechia | |
Lens Crystalline, Cataract | 4 |
Retina, Atrophy | 4 |
Sclera, Mineralization, Multifocal | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 3|
DAY ON TEST | 3| 4| 3| 3| 3| 8| 3| 3| 4| 0| 7| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 7| 1| 3|
| 2| 0| 2| 2| 2| 3| 2| 3| 9| 9| 5| 3| 3| 0| 3| 3| 4| 3| 4| 4| 9| 5| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
240 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + +|
Nephropathy, Multifocal | 2 1 3 2 2 2 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5| |
| 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + +| 14 |
Diverticulum | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + +| 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X X | 24 |
Clear Cell Focus | X X | 10 |
Degeneration, Cystic | 1 1 1 1 2 | 9 1.2|
Eosinophilic Focus | X X | 5 |
Fatty Change | 3 | 1 3.0|
Necrosis, Coagulative, Focal | 1 1 | 2 1.0|
Necrosis, Coagulative, Multifocal | 1 | 1 1.0|
Regeneration, Focal | 3 | 1 3.0|
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 24 1.0|
Centrilobular, Necrosis, Coagulative | 2 | 2 2.5|
Sinusoid, Angiectasis, Focal | | 1 1.0|
Sinusoid, Angiectasis | 3 2 | 3 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + +| 16 |
Acinus, Atrophy | 2 3 2 1 2 2| 11 2.1|
Acinus, Hypertrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + +| 16 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + +| 18 |
Dilatation | 3 | 1 3.0|
Atrium, Dilatation | | 2 3.5|
Atrium Left, Thrombosis | | 1 |
Myocardium, Degeneration, Multifocal | 1 2 3 3 2 3| 14 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5| |
| 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Myocardium, Inflammation, Chronic, | | |
Focal | 1 | 2 1.5|
Myocardium, Inflammation, Chronic, | | |
Multifocal | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Nodular | 3 4 3 3 2 1 1| 13 2.3|
Hypertrophy, Focal | 1 | 2 1.0|
Mineralization, Multifocal | 1 | 1 1.0|
Vacuolization Cytoplasmic, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 1 1 3 1 2 1 1 1 2 2 2 1| 26 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + +| 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + +| 20 |
Pars Distalis, Hyperplasia, Nodular | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + +| 14 |
C-Cell, Hyperplasia | 3 1 2 | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + +| 17 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + +| 18 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 1 1 3 1 2 3| 15 1.9|
Inflammation, Chronic Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + +| 17 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | | 2 1.0|
Seminiferous Tubule, Atrophy | 4 4 4 3 4 4 4 4 | 15 3.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + +| 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5| |
| 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Femoral, Hyperplasia | 4 2 3 3 2| 11 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 19 |
Mandibular, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Sinus, Ectasia | 2 | 1 2.0|
Sinus, Mandibular, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 4 |
Sinus, Ectasia | 3 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 29 |
Fibrosis, Focal | | 3 2.3|
Hematopoietic Cell Proliferation | 4 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M| 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 8 |
Hyperplasia, Cystic | 2 3 | 5 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + +| 20 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Granulomatous | | 1 3.0|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + +| 18 |
Tibia, Fracture Healed | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + +| 17 |
Infarct | 4 | 2 2.5|
Hypothalamus, Compression | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + +| 18 |
Bacterium | | 1 |
Congestion | | 2 2.5|
Alveolus, Hemorrhage | | 4 1.8|
Interstitium, Inflammation, Chronic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 0| 5| |
| 5| 5| 5| 9| 9| 1| 4| 7| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 7| 2| 2| 2| 3| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
240 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal | 1 | 2 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + +| 17 |
__________________________________________________________________________|____________|
Trachea | + + + + + +| 17 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + | 6 |
Anterior, Synechia | 3 | 1 3.0|
Lens Crystalline, Cataract | 4 3 3 2 1 | 6 2.8|
Retina, Atrophy | 4 4 4 3 3 | 6 3.7|
Sclera, Mineralization, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 21 |
Nephropathy, Multifocal | 4 3 2 1 1 2 3 4 1 3| 20 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + +| 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|
| 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A +|
Inflammation, Chronic, Focal | 2|
__________________________________________________________________________|
Intestine Large, Colon | + M + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A +|
Inflammation, Necrotizing | 2|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X X |
Fatty Change | 2 |
Necrosis, Coagulative, Multifocal | |
Centrilobular, Cytomegaly | 1 1 2 1 2 1 1 1 |
Centrilobular, Hemorrhage | |
Centrilobular, Necrosis, Coagulative | 3 |
Centrilobular, Necrosis, Caseous | 3 |
Sinusoid, Angiectasis | 1 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A +|
Acinus, Atrophy | 2 1 2 3 1 |
Acinus, Hyperplasia | 3 |
Artery, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
Ulcer | 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + +|
Atrium Left, Thrombosis | X|
Mitral Valve, Thrombosis | X |
Myocardium, Degeneration, Multifocal | 3 1 2 3 1 2 2 2 1|
Myocardium, Inflammation, Chronic | |
Active, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|
| 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Hyperplasia, Nodular | 2 1 2 2 1 2 1 3 1 1 1 1 1 1 2 2|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Nodular | 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A +|
C-Cell, Hyperplasia | 2 3 1 2 2 2 4 4 3|
Follicle, Dilatation, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + + + +|
Inflammation, Chronic | 1 3 2 2 2 2 2 3 1 |
Inflammation, Chronic Active | 2 3|
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A +|
Femoral, Hyperplasia | 2 3 1 3 3 2 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Mandibular, Inflammation, Necrotizing| |
Mediastinal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Fibrosis, Diffuse | 2 |
Fibrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 0| 3| 6| 9| 3| 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 4| 3| 3| 7|
| 2| 8| 2| 8| 0| 2| 3| 3| 3| 0| 2| 4| 4| 7| 5| 5| 8| 5| 8| 5| 9| 8| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Fungus | X |
Hyperkeratosis | 1 |
Inflammation, Chronic | |
Inflammation, Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + +|
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hemorrhage | |
Artery, Mineralization | 1 1 |
Interstitium, Inflammation, Chronic, | |
Multifocal | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens Crystalline, Cataract | 2 3 |
Posterior Chamber, Inflammation, | |
Chronic | |
Retina, Atrophy | 3 4 |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + +|
Nephropathy, Multifocal | 2 2 3 2 2 2 3 3 2 1 1 1 4|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A +|
Mucosa, Inflammation, Proliferative | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4| |
| 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + | 22 |
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + | 22 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 23 |
Inflammation, Necrotizing | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X| 15 |
Clear Cell Focus | X X X | 8 |
Degeneration, Cystic | 2 1 | 3 1.3|
Eosinophilic Focus | X X X | 6 |
Fatty Change | | 1 2.0|
Necrosis, Coagulative, Multifocal | 1 | 1 1.0|
Centrilobular, Cytomegaly | 1 2 1 1 1 | 13 1.2|
Centrilobular, Hemorrhage | 4 | 1 4.0|
Centrilobular, Necrosis, Coagulative | 1 | 2 2.0|
Centrilobular, Necrosis, Caseous | | 1 3.0|
Sinusoid, Angiectasis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 23 |
Acinus, Atrophy | 2 2 3 1 2 2 2 1 | 13 1.8|
Acinus, Hyperplasia | | 1 3.0|
Artery, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 24 |
Ulcer | 4 | 2 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 25 |
Atrium Left, Thrombosis | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4| |
| 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mitral Valve, Thrombosis | | 1 |
Myocardium, Degeneration, Multifocal | 3 1 4 2 2 2 2 | 16 2.1|
Myocardium, Inflammation, Chronic | | |
Active, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Nodular | 1 1 1 1 1 3 1 2| 8 1.4|
Inflammation, Necrotizing | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
Hyperplasia, Nodular | 1 1 2 3 2 2 1 1 | 24 1.5|
Inflammation, Necrotizing | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + +| 31 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia, Nodular | 1 2 | 4 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + + + + + + | 22 |
C-Cell, Hyperplasia | 3 3 2 4 3 2 2 2 | 17 2.6|
Follicle, Dilatation, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 24 |
Inflammation, Chronic | 1 2 3 2 2 1 3 2 2 1 2 1 | 21 1.9|
Inflammation, Chronic Active | | 2 2.5|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Seminiferous Tubule, Atrophy | 4 4 4 4 3 | 12 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 23 |
Femoral, Hyperplasia | 4 4 3 3 3 2 2 | 15 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4| |
| 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 26 |
Mandibular, Inflammation, Necrotizing| 2 | 1 2.0|
Mediastinal, Sinus, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 5 |
Sinus, Ectasia | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 31 |
Fibrosis, Diffuse | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + | 23 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 7 |
Hyperplasia, Cystic | 1 4 2 | 5 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 31 |
Acanthosis | | 1 3.0|
Fungus | | 1 |
Hyperkeratosis | | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 25 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 24 |
Hypothalamus, Compression | 4 2 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 24 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Hemorrhage | 2 3 2 | 3 2.3|
Artery, Mineralization | | 2 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 25 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 1| 3| 4| 7| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 2| 0| 4| 0| 2| 0| 4| 7| 1| 1| 4| |
| 7| 9| 0| 1| 3| 0| 0| 0| 1| 1| 1| 4| 0| 1| 6| 9| 2| 6| 9| 9| 2| 6| 5| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + +| 4 |
Lens Crystalline, Cataract | 4 4| 4 3.3|
Posterior Chamber, Inflammation, | | |
Chronic | 3 3| 2 3.0|
Retina, Atrophy | | 2 3.5|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 28 |
Nephropathy, Multifocal | 1 2 4 2 2 2 3 2 3 2 3 3 1 | 26 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 23 |
Mucosa, Inflammation, Proliferative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|
| 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + A + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + A + +|
Peyer's Patch, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +|
Basophilic Focus | X X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | X X X X X X |
Fatty Change | |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | X |
Regeneration, Focal | |
Regeneration, Multifocal | |
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 |
Centrilobular, Necrosis, Coagulative | 4 |
Sinusoid, Angiectasis | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + A + + +|
Acinus, Atrophy | 3 1 1 2 1 2|
Artery, Inflammation, Chronic | 2 2 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + A + +|
__________________________________________________________________________|
Stomach | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + A + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + A + +|
Ulcer | |
Mucosa, Mineralization, Multifocal | |
__________________________________________________________________________|
Tongue | + + |
Cyst | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + +|
Infarct | 2 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|
| 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Dilatation | |
Atrium Left, Thrombosis | X X |
Endocardium, Proliferation | |
Myocardium, Degeneration, Multifocal | 2 1 3 2 1 2 2 1 1 2 2 2|
Valve, Bacterium | X |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + A + + +|
Hyperplasia, Nodular | 2 2 1 1 1 2 |
Hypertrophy, Focal | 1 3 |
Necrosis, Coagulative, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + A + + +|
Hyperplasia, Nodular | 1 1 3 2 2 1 1 1 2 1 2 2 1 |
Necrosis, Coagulative, Diffuse | |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + A + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + A + +|
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + A + +|
C-Cell, Hyperplasia | 3 2 2 3 2 2 3 2 2 2 3|
Follicle, Dilatation, Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + M + A + +|
Granuloma Sperm | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Autolysis, Diffuse | 3 |
Inflammation, Chronic | 1 2 1 2 1 1 3 2 2 2 1 2|
Inflammation, Chronic Active | 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + A + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis, Diffuse | 3 |
Seminiferous Tubule, Atrophy | 4 4 3 4 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|
| 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Hyperplasia | 3 4 3 3 1 3 3 2 |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + A + +|
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + +|
Fibrosis, Focal | 1 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + +|
Hyperplasia, Cystic | 3 2 1 2 1 4|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | |
Tail, Necrosis, Coagulative, Diffuse | 4 |
Tail, Dermis, Epidermis, Bacterium | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Abscess | 3 |
Artery, Bacterium | X |
Cerebellum, Neuron, Necrosis, Focal | |
Hypothalamus, Compression | 4 3|
Ventricle, Hydrocephalus | |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Alveolus, Hemorrhage | 2 |
Alveolus, Hemorrhage, Multifocal | 1 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 6| 0| 3| 8| 0| 3| 6| 3| 3| 3| 0| 3| 0| 3| 0| 3| 3| 9| 2| 8| 6| 3| 4|
| 2| 2| 1| 1| 2| 8| 6| 2| 7| 3| 3| 3| 6| 4| 9| 4| 4| 4| 5| 5| 0| 7| 4| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Chronic | |
Pinna, Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Eye | + |
Lens Capsule, Cataract | |
Lens Crystalline, Cataract | 4 |
Posterior Chamber, Inflammation, | |
Chronic | 3 |
Sclera, Mineralization, Multifocal | 2 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Multifocal | 1 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 4 |
Inflammation, Multifocal, Necrotizing| 4 |
Nephropathy, Multifocal | 2 3 2 1 2 4 2 4 3 3 1 2 1|
Pelvis, Inflammation, Suppurative | |
Renal Tubule, Bacterium | X |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + A + +|
Inflammation, Acute | |
Lamina Propria, Edema | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + | 26 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + | 26 |
Peyer's Patch, Inflammation, | | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X | 12 |
Clear Cell Focus | X X | 6 |
Degeneration, Cystic | 1 2 1 1 1 | 5 1.2|
Eosinophilic Focus | X X | 8 |
Fatty Change | 3 3 3 | 3 3.0|
Hepatodiaphragmatic Nodule | X | 1 |
Mixed Cell Focus | | 1 |
Regeneration, Focal | 1 2 | 2 1.5|
Regeneration, Multifocal | 4 | 1 4.0|
Centrilobular, Cytomegaly | 1 1 1 1 2 1 | 14 1.1|
Centrilobular, Necrosis, Coagulative | | 1 4.0|
Sinusoid, Angiectasis | 1 1| 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 28 |
Acinus, Atrophy | 2 3 1 1 1 1 1 1 2 2 1 | 17 1.5|
Artery, Inflammation, Chronic | | 2 2.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 27 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 27 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 27 |
Ulcer | 4 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + | 26 |
Ulcer | 2 | 1 2.0|
Mucosa, Mineralization, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 29 |
Infarct | | 1 2.0|
Atrium, Dilatation | 4 | 1 4.0|
Atrium Left, Thrombosis | | 2 |
Endocardium, Proliferation | 1 | 1 1.0|
Myocardium, Degeneration, Multifocal | 2 1 2 1 1 1 1 2 2 2 1 3 1 | 25 1.6|
Valve, Bacterium | | 1 |
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Nodular | 1 2 1 3 | 10 1.6|
Hypertrophy, Focal | 2 | 3 2.0|
Necrosis, Coagulative, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Nodular | 1 2 2 2 2 1 1 2 2 3 2 1 1 2 2 4 1 | 30 1.7|
Necrosis, Coagulative, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 28 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + | 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 30 |
Pars Distalis, Angiectasis, Focal | | 1 2.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Nodular | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + + + + + A | 27 |
C-Cell, Hyperplasia | 2 2 2 4 2 2 2 4 | 19 2.4|
Follicle, Dilatation, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 27 |
Granuloma Sperm | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 33 |
Autolysis, Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 2 4 2 2 1 2 1 2 1 2 1 2 | 25 1.8|
Inflammation, Chronic Active | 4 3 2 | 4 3.0|
Duct, Ectasia | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 28 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis, Diffuse | | 1 3.0|
Seminiferous Tubule, Atrophy | 3 4 4 4 4 4 4 | 13 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 28 |
Femoral, Hyperplasia | 3 4 4 2 3 3 3 3 | 16 2.9|
Femoral, Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 8 |
Sinus, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 35 |
Fibrosis, Focal | 3 | 3 2.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 14 |
Hyperplasia, Cystic | 4 2 2 1 3 2 | 12 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 29 |
Subcutaneous Tissue, Edema | 4 | 1 4.0|
Tail, Necrosis, Coagulative, Diffuse | | 1 4.0|
Tail, Dermis, Epidermis, Bacterium | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 29 |
Femur, Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 29 |
Abscess | | 1 3.0|
Artery, Bacterium | | 1 |
Cerebellum, Neuron, Necrosis, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 6| 3| 6| 6| 4| 4| 6| 0| 8| 5| 2| 4| 7| 2| 4| 4| 3| 2| 4| |
| 7| 4| 5| 9| 9| 9| 1| 3| 1| 0| 0| 0| 8| 1| 9| 2| 6| 1| 3| 9| 1| 2| 4| 6| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hypothalamus, Compression | 3 4 3 | 5 3.4|
Ventricle, Hydrocephalus | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 30 |
Alveolus, Hemorrhage | | 1 2.0|
Alveolus, Hemorrhage, Multifocal | | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 29 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Middle Ear, Inflammation, Chronic | 2 | 1 2.0|
Pinna, Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Eye | + + | 3 |
Lens Capsule, Cataract | 2 | 1 2.0|
Lens Crystalline, Cataract | 3 | 2 3.5|
Posterior Chamber, Inflammation, | | |
Chronic | 3 | 2 3.0|
Sclera, Mineralization, Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 31 |
Hemorrhage, Focal | | 1 4.0|
Inflammation, Multifocal, Necrotizing| | 1 4.0|
Nephropathy, Multifocal | 4 1 1 4 2 2 3 4 4 1 1 3 1 2 1 | 28 2.3|
Pelvis, Inflammation, Suppurative | 3 | 1 3.0|
Renal Tubule, Bacterium | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 27 |
Inflammation, Acute | 3 | 1 3.0|
Lamina Propria, Edema | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|
| 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + A + + + + + + +|
Ulcer | 1 |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + A + + + + + + + +|
Inflammation, Necrotizing | |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X X |
Congestion | 2 |
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X X X |
Fatty Change | 1 2 |
Hepatodiaphragmatic Nodule | |
Mixed Cell Focus | X X X |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 2 |
Regeneration, Focal | 2 |
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Sinusoid, Angiectasis | 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 2 2 1 2 1 |
Artery, Inflammation, Acute | 2 |
Artery, Inflammation, Chronic | 1 3 |
__________________________________________________________________________|
Salivary Glands | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + +|
Epithelium, Acanthosis, Diffuse | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Atrium Left, Thrombosis | X X |
Myocardium, Degeneration, Multifocal | 3 3 1 2 3 2 2 3 3 2 3 1 3 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|
| 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 1 3 2 2 2 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 3 1 2 1 2 2 2 2 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + A + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + A A + + + + A + + + + + + +|
C-Cell, Hyperplasia | 3 3 2 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic | 1 2 1 3 1 1 1 2 2 2 2 |
Inflammation, Chronic Active | 1 3 3 2|
Duct, Ectasia | 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Granuloma | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 2 3 2 2 2 3 2 4 4 2|
__________________________________________________________________________|
Lymph Node | + + + A + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Sinus, Ectasia | 2 |
Sinus, Mandibular, Ectasia | 3|
__________________________________________________________________________|
Lymph Node, Bronchial | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|
| 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 1 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Hyperplasia, Cystic | 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Congestion | 4 3 |
Interstitium, Hemorrhage, Chronic, | |
Multifocal | |
Interstitium, Inflammation, Chronic | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Sinus, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Pinna, Acanthosis | |
__________________________________________________________________________|
Eye | + + |
Lens Crystalline, Cataract | 3 |
Posterior Chamber, Inflammation, | |
Chronic | |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Nephropathy, Multifocal | 2 2 1 2 3 2 1 1 2 3 3 2 2 3 3 1|
Renal Tubule, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + M A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 3| 6| 6| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 0| 3| 4| 3| 1| 3| 3| 5| 2| 3| 3| 0| 3| 0| 5| 6| 8| 3| 2| 1| 0| 3| 9|
| 2| 2| 1| 3| 3| 2| 7| 3| 3| 2| 3| 3| 4| 1| 4| 7| 9| 2| 0| 4| 3| 1| 9| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
800 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Metaplasia, | |
Focal, Squamous | 1 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4| |
| 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 27 |
__________________________________________________________________________|____________|
Intestine Large | A + A + + A A + A + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + A A + A + + + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + A + + A A + A + + + + | 23 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + A + + A A + A + + + + | 22 |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + A A + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A A + + + + + + | 25 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + A A + A + + + + | 23 |
Inflammation, Necrotizing | 4 | 1 4.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + A A + A + + + + | 22 |
__________________________________________________________________________|____________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X X | 26 |
Clear Cell Focus | X | 3 |
Congestion | | 1 2.0|
Degeneration, Cystic | 1 | 2 1.0|
Eosinophilic Focus | X X X X X X X| 11 |
Fatty Change | 1 | 3 1.3|
Hepatodiaphragmatic Nodule | X | 1 |
Mixed Cell Focus | X X | 5 |
Necrosis, Coagulative, Focal | 1 | 1 1.0|
Necrosis, Coagulative, Multifocal | | 1 2.0|
Regeneration, Focal | 1 | 2 1.5|
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
Sinusoid, Angiectasis | 1 1 1| 5 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | A + + + + A A + + + + + + | 25 |
Acinus, Atrophy | 2 1 3 3 1 3 | 14 1.8|
Artery, Inflammation, Acute | | 1 2.0|
Artery, Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 28 |
__________________________________________________________________________|____________|
Stomach | A + + + + + A + + + + + + | 26 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + A + + + + + + | 26 |
Epithelium, Acanthosis, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + A + + A A + A + + + + | 23 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4| |
| 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 29 |
Atrium Left, Thrombosis | | 2 |
Myocardium, Degeneration, Multifocal | 2 2 3 2 2 2 2 1 3 3 3 2 | 27 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Nodular | 1 1 2 2 1 3 3 1 1 1 1 1 2 2| 19 1.7|
Hypertrophy, Focal | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Nodular | 1 2 2 2 1 1 1 1 2 2| 21 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + A A + + + + + + | 25 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + M + +| 27 |
Pars Distalis, Hyperplasia, Nodular | | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | A + + + + A + + + + + + | 23 |
C-Cell, Hyperplasia | 1 3 3 1 2 3 1 | 16 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 29 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 1 2 1 1 2 3 1 2 2 1 | 21 1.6|
Inflammation, Chronic Active | 2 1 2 | 7 2.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + | 29 |
Granuloma | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
Seminiferous Tubule, Atrophy | 2 2 4 4 4 4 | 9 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 29 |
Femoral, Hyperplasia | 2 2 2 2 3 3 | 16 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4| |
| 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Mediastinal, Sinus, Ectasia | | 1 2.0|
Sinus, Mandibular, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 4 |
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + | 29 |
Hematopoietic Cell Proliferation | | 1 1.0|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M + + | 25 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 7 |
Hyperplasia, Cystic | 2 1 2 | 6 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 30 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 27 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 29 |
Hypothalamus, Compression | 2 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 29 |
Congestion | | 2 3.5|
Interstitium, Hemorrhage, Chronic, | | |
Multifocal | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | 1 | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 29 |
Sinus, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 5| 7| 5| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 0| 8| 5| 4| 4| 4| 1| 4| 4| 9| 4| 4| 1| 4| 9| 4| 1| 4| 4| 4| |
| 5| 0| 5| 9| 3| 5| 0| 0| 0| 0| 0| 0| 3| 1| 4| 1| 1| 8| 2| 7| 2| 7| 8| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
800 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
Pinna, Acanthosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
Lens Crystalline, Cataract | 4 4 4 2 | 5 3.4|
Posterior Chamber, Inflammation, | | |
Chronic | 3 2 | 2 2.5|
Retina, Atrophy | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + + + | 30 |
Nephropathy, Multifocal | 2 4 3 2 1 1 3 2 1 1 1 | 27 2.0|
Renal Tubule, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + A A + + + + + + | 24 |
Transitional Epithelium, Metaplasia, | | |
Focal, Squamous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|
| 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
Parasite Metazoan | X X X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X|
Clear Cell Focus | X |
Degeneration, Cystic | 1 4 1 |
Eosinophilic Focus | X X X X X X |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | |
Regeneration, Multifocal | |
Centrilobular, Cytomegaly | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Serosa, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | |
Necrosis | 2 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 1 2 1 1 |
Artery, Inflammation, Chronic | 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Thrombosis | X |
Parotid Gland, Hyperplasia, Lobular | 3 |
Parotid Gland, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|
| 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Submucosa, Edema | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
Submucosa, Edema | |
__________________________________________________________________________|
Tooth | + |
Gingiva, Inflammation, Necrotizing | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Dilatation | 4 3 |
Atrium Left, Thrombosis | X |
Myocardium, Degeneration, Multifocal | 1 2 1 2 2 2 2 2 2 1 2 3 2 3 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Nodular | 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Nodular | 3 2 2 2 2 1 1 3 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 2 1 |
Pars Nervosa, Inflammation, Chronic | 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 3 3 2 2 2 2 3 3 1 1 3 2 3 2 3 3 3|
Follicle, Dilatation, Multifocal | |
Follicular Cell, Hyperplasia, Nodular| 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
Inflammation, Chronic | 1 1 1 1 1 2 1 3 3 1 1 2 2 3 3 1 3 1 1 1 1|
Inflammation, Chronic Active | 3 |
Duct, Ectasia | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|
| 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 4 |
Seminiferous Tubule, Atrophy | 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 1 2 2 2 2 1 2 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Sinus, Ectasia | 3 |
Renal, Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Fibrosis | 4 |
Giant Cell | 2 |
Metaplasia, Focal, Osseous | 2 |
Thrombosis | X |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + M M + M + M M + + + + + + + + M + + + M M M + M|
Arteriole, Inflammation, Chronic | 1 |
Arteriole, Thrombosis | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Hyperplasia, Cystic | 1 1 1 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic | 2 |
Inflammation, Necrotizing | |
Sebaceous Gland, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Hypothalamus, Compression | 4 |
Third Ventricle, Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 3| 3| 3| 8| 9| 2| 3| 3| 3| 1| 3| 3| 1| 3| 3| 3| 3| 9| 4| 3| 3| 3| 4|
| 5| 7| 1| 2| 2| 0| 7| 9| 3| 3| 3| 1| 4| 4| 5| 4| 5| 5| 5| 6| 7| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Inflammation, Chronic, | |
Diffuse | 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 1 |
Interstitium, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Inflammation, Chronic| 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens Crystalline, Cataract | 1 2 |
Posterior Chamber, Inflammation, | |
Chronic | 2 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic, Multifocal | 1 1 |
__________________________________________________________________________|
Zymbal's Gland | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Multifocal | 2 1 1 3 2 3 3 4 3 4 3 4 4 4 1 3 3 4 2 4 2 3 3 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 114
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + A + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + A + + + + A| 47 |
Submucosa, Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + A + + M + A| 46 |
Inflammation, Chronic Active, Focal | 3 | 1 3.0|
Parasite Metazoan | X X X | 6 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + A + + + + A| 47 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + A| 47 |
Inflammation, Chronic, Focal | 1 3 | 2 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + A| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 4 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | 1 | 4 1.8|
Eosinophilic Focus | X X | 8 |
Fatty Change | 1 3 | 2 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Mixed Cell Focus | | 3 |
Necrosis, Coagulative, Focal | 1 1| 2 1.0|
Necrosis, Coagulative, Multifocal | 2 2 | 2 2.0|
Regeneration, Multifocal | 2 2 | 2 2.0|
Centrilobular, Cytomegaly | 1 1 1 2 1 1 1 1 1 | 27 1.1|
Serosa, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | | 1 2.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + M + + + + + A| 48 |
Acinus, Atrophy | 2 1 1 2 1 2 2 1 2 1 1 1 | 18 1.4|
Artery, Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Arteriole, Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Parotid Gland, Hyperplasia, Lobular | | 1 3.0|
Parotid Gland, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Hyperkeratosis | | 1 4.0|
Ulcer | 4 3 | 2 3.5|
Submucosa, Edema | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Inflammation, Chronic | 1 | 1 1.0|
Ulcer | 3 3 | 2 3.0|
Submucosa, Edema | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Inflammation, Necrotizing | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Dilatation | | 2 3.5|
Atrium Left, Thrombosis | | 1 |
Myocardium, Degeneration, Multifocal | 2 3 1 2 1 1 1 3 3 2 1 2 1 1 1 2 2 1 2 | 34 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Nodular | 1 2 3 2 3 1 | 10 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Nodular | 1 2 2 2 2 1 1 | 17 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Diffuse | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia, Nodular | 3 3 | 4 2.3|
Pars Nervosa, Inflammation, Chronic | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + A| 48 |
C-Cell, Hyperplasia | 2 3 2 1 3 2 3 2 3 2 2 2 1 3 2 2 3 | 36 2.3|
Follicle, Dilatation, Multifocal | 1 | 1 1.0|
Follicular Cell, Hyperplasia, Nodular| | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 3 2.3|
Inflammation, Chronic | 2 1 2 1 1 1 1 2 1 1 2 1 1 1 1 3 1 2 1 1 1 2 2| 44 1.5|
Inflammation, Chronic Active | | 1 3.0|
Duct, Ectasia | 3| 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Interstitial Cell, Hyperplasia | 4 3 | 4 3.5|
Seminiferous Tubule, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Femoral, Hyperplasia | 1 1 2 3 2 2 3 3 3 3 3 2 2 3 | 22 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Sinus, Ectasia | | 1 3.0|
Renal, Sinus, Ectasia | 1 4 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 8 |
Fibrosis | | 1 4.0|
Giant Cell | | 1 2.0|
Metaplasia, Focal, Osseous | | 1 2.0|
Thrombosis | | 1 |
Sinus, Ectasia | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + M M + M M + + + + M + + + + + + + + + + + + + +| 35 |
Arteriole, Inflammation, Chronic | | 1 1.0|
Arteriole, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 19 |
Hyperplasia, Cystic | 1 1 1 1 1 1 2 2 2 3 4 | 17 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Necrotizing | 3 4| 2 3.5|
Sebaceous Gland, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 3 4| 2 3.5|
Hypothalamus, Compression | 3 4 | 3 3.7|
Third Ventricle, Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitium, Inflammation, Chronic, | | |
Diffuse | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 2 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lamina Propria, Inflammation, Chronic| | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
Lens Crystalline, Cataract | 1 3 | 4 1.8|
Posterior Chamber, Inflammation, | | |
Chronic | | 1 2.0|
Retina, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Inflammation, Chronic, Multifocal | | 2 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | +| 1 |
Inflammation, Suppurative | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Multifocal | 2 4 3 2 3 3 2 3 2 3 2 4 3 4 2 1 1 3 1 4 3 4 3 | 48 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 4| 7| 6| 6| 6| 7| 4| 2| 6| 6| 4| 6| 7| 7| 7| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 0| 8| 4| 9| 7| 4| 9| 6| 8| 4| 9| 0| 6| 6| 9| 8| 3| 4| 2| 2| 2| 4| 4| 4| 3| |
| 9| 9| 0| 6| 5| 0| 5| 7| 3| 1| 0| 9| 2| 6| 4| 7| 6| 1| 2| 5| 5| 2| 2| 2| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Dilatation | 4 | 2 4.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 0| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 1|
| 7| 5| 2| 2| 2| 2| 3| 3| 3| 3| 7| 3| 3| 9| 9| 4| 4| 4| 4| 5| 5| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Ulcer | 3 |
Submucosa, Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + M + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 1 |
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X X X |
Degeneration, Cystic | 2 2 |
Eosinophilic Focus | X X X X |
Fatty Change | 1 |
Mixed Cell Focus | X X X X |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative, Multifocal | 2 |
Regeneration, Focal | |
Centrilobular, Congestion | 3 |
Centrilobular, Cytomegaly | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Necrosis | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 1 1 3 1 2 1 1 1 4 2 1 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Sublingual Gland, Atrophy | |
Submandibular Gland, Necrosis, | |
Caseous | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Ulcer | |
Submucosa, Edema | |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 0| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 1|
| 7| 5| 2| 2| 2| 2| 3| 3| 3| 3| 7| 3| 3| 9| 9| 4| 4| 4| 4| 5| 5| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Coronary Artery, Intima, | |
Necrosis, Fibrinoid | |
Atrium, Dilatation | 4 |
Atrium Left, Thrombosis | X |
Coronary Artery, Inflammation, | |
Chronic | 1 |
Endocardium, Proliferation | 2 |
Myocardium, Degeneration, Multifocal | 1 2 1 1 2 4 1 1 2 3 1 2 1 3 2 3 2 1 1|
Myocardium, Fibrosis, Focal | 1 |
Myocardium, Infarct | |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 1 2 1 1 1 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Nodular | 2 2 1 1 3 2 1 3 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + A + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 1 |
Pars Nervosa, Inflammation, Chronic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 2 1 2 3 1 1 1 2 3 3 1 2 1 2|
C-Cell, Mineralization, Multifocal | |
Follicle, Dilatation, Multifocal | |
Follicular Cell, Vacuolization | |
Cytoplasmic, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 121
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 0| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 1|
| 7| 5| 2| 2| 2| 2| 3| 3| 3| 3| 7| 3| 3| 9| 9| 4| 4| 4| 4| 5| 5| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 3 2 2 1 |
Inflammation, Chronic Active | 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + M + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 1 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 3 2 1 1 2 3 1 3 1 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Sinus, Ectasia | |
Lumbar, Necrosis, Caseous | |
Mandibular, Necrosis, Caseous | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + +|
Sinus, Ectasia | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 2 |
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + M + + + + M M M + M + + + + + + + + M M + + +|
Cyst | |
Ectopic Parathyroid Gland | |
Arteriole, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + |
Hyperplasia, Cystic | 1 2 1 1 2 1 3 1 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Mineralization, Focal | 1 |
Fourth Ventricle, Hydrocephalus | |
Hypothalamus, Compression | 2 |
_____________________________________________________________________________________________________________________|
Page 122
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6|
DAY ON TEST | 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 0| 3| 3| 7| 3| 3| 3| 3| 3| 5| 3| 1|
| 7| 5| 2| 2| 2| 2| 3| 3| 3| 3| 7| 3| 3| 9| 9| 4| 4| 4| 4| 5| 5| 5| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2400 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | 1 |
Artery, Mineralization | 1 1 |
Interstitium, Inflammation, Chronic, | |
Diffuse | 2 |
Interstitium, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Inflammation, Chronic| 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Inflammation, Chronic | |
__________________________________________________________________________|
Eye | + + + + |
Lens Crystalline, Cataract | 1 2 2 |
Posterior Chamber, Inflammation, | |
Chronic | 2 3 |
Retina, Atrophy | 4 |
Retina, Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | |
Nephropathy, Multifocal | 1 2 2 3 3 3 2 3 3 2 3 2 4 2 1 2 3 3 3 2 3 3 1 2 2|
Fat, Hematopoietic Cell Proliferation| 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 123
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Ulcer | | 1 3.0|
Submucosa, Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Inflammation, Chronic, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Inflammation, Chronic, Focal | | 2 1.5|
Peyer's Patch, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Basophilic Focus | X | 7 |
Clear Cell Focus | X X X | 7 |
Degeneration, Cystic | 1 1 1 1 1 | 7 1.3|
Eosinophilic Focus | X X X | 7 |
Fatty Change | 3 2 | 3 2.0|
Mixed Cell Focus | X X | 6 |
Necrosis, Coagulative, Focal | 1 | 1 1.0|
Necrosis, Coagulative, Multifocal | 2 | 2 2.0|
Regeneration, Focal | 2 | 1 2.0|
Centrilobular, Congestion | | 1 3.0|
Centrilobular, Cytomegaly | 2 1 2 1 1 1 1 1 1 2 1 1 1 1| 31 1.1|
__________________________________________________________________________|____________|
Mesentery | + + + + | 4 |
Inflammation, Chronic | 1 | 1 1.0|
Necrosis | 2 | 1 2.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 1 2 1 2 2 1 2 2 2 3 3| 24 1.8|
Artery, Inflammation, Chronic | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Sublingual Gland, Atrophy | 1 | 1 1.0|
Submandibular Gland, Necrosis, | | |
Caseous | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 124
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Hyperkeratosis | 3 4 | 3 3.0|
Ulcer | 3 | 1 3.0|
Submucosa, Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arteriole, Coronary Artery, Intima, | | |
Necrosis, Fibrinoid | 3 | 1 3.0|
Atrium, Dilatation | | 1 4.0|
Atrium Left, Thrombosis | | 1 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 1.0|
Endocardium, Proliferation | | 1 2.0|
Myocardium, Degeneration, Multifocal | 2 2 1 2 2 1 2 2 2 1 1 2 2 3 1 1 1 2 2 3 3| 40 1.8|
Myocardium, Fibrosis, Focal | | 1 1.0|
Myocardium, Infarct | 3 | 1 3.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | 1 1 1 2 | 11 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Hyperplasia, Nodular | 1 1 2 1 1 1 | 15 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + + M M + + + + + + + M + M + + + + + +| 44 |
Hyperplasia, Diffuse | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia, Nodular | 1 2 1 | 4 1.3|
Pars Nervosa, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 1 1 2 2 1 1 3 3 1 1 2| 30 1.7|
C-Cell, Mineralization, Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 125
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Dilatation, Multifocal | 3 | 1 3.0|
Follicular Cell, Vacuolization | | |
Cytoplasmic, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
Inflammation, Chronic | 1 1 3 1 2 2 2 1 1 2 1| 29 1.4|
Inflammation, Chronic Active | 2 3 3 3 | 5 2.8|
Duct, Ectasia | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Artery, Inflammation, Chronic | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 2 1 1 | 5 1.2|
Seminiferous Tubule, Atrophy | 4 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | 1 1 3 3 3 1 3 2 3 1 3 2 3 2 1| 26 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Sinus, Ectasia | 4 | 1 4.0|
Lumbar, Necrosis, Caseous | 4 | 1 4.0|
Mandibular, Necrosis, Caseous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 8 |
Sinus, Ectasia | 4 | 3 3.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + M + M + + + + + + + M +| 39 |
Cyst | X | 1 |
Ectopic Parathyroid Gland | X | 1 |
Arteriole, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 126
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 18 |
Hyperplasia, Cystic | 2 1 1 1 1 | 16 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fibrous Osteodystrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 | 2 2.0|
Mineralization, Focal | | 1 1.0|
Fourth Ventricle, Hydrocephalus | 2 | 1 2.0|
Hypothalamus, Compression | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal, Subacute | | 1 1.0|
Artery, Mineralization | 1 | 3 1.0|
Interstitium, Inflammation, Chronic, | | |
Diffuse | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lamina Propria, Inflammation, Chronic| 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 3 |
Middle Ear, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + + + | 8 |
Lens Crystalline, Cataract | 3 2 3 4 | 7 2.4|
Posterior Chamber, Inflammation, | | |
Chronic | 2 | 3 2.3|
Retina, Atrophy | 4 4 4 4 | 5 4.0|
Retina, Mineralization, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 127
NTP Experiment-Test: 05075-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIPHENYLHYDANTOIN Date: 04/29/97
Route: DOSED FEED Time: 07:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 6| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 2| 6| 6| 4| 2| 3| 3| 4| 4| 4| 1| 4| 4| 8| 4| 9| 6| 4| 4| 3| 4| 5| 4| |
| 9| 9| 0| 1| 8| 8| 8| 9| 9| 0| 0| 0| 5| 1| 1| 1| 1| 9| 5| 1| 2| 7| 2| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
2400 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Hemorrhage | 4 | 1 4.0|
Nephropathy, Multifocal | 3 1 2 2 4 2 1 4 2 2 3 2 2 2 3 1 4 1 1 2 2 2 4 2| 49 2.3|
Fat, Hematopoietic Cell Proliferation| | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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