TDMS Study 05077-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
NTP Experiment-Test: 05077-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
Facility: Battelle Columbus Laboratory
Chemical CAS #: 67774327
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 7 3 5 2 4 8
Natural Death 4 2 13 10 13 25
Survivors
Terminal Sacrifice 39 45 32 38 33 17
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (50) (45) (46) (38) (45)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
Epithelium, Inclusion Body Intracytoplasmic 1 (2%) 1 (3%)
Intestine Large, Cecum (47) (50) (49) (50) (46) (50)
Parasite Metazoan 1 (2%) 2 (4%) 2 (4%) 5 (10%)
Mucosa, Hyperplasia 1 (2%)
Intestine Large, Colon (48) (50) (49) (49) (47) (50)
Parasite Metazoan 2 (4%) 2 (4%) 1 (2%) 2 (4%) 5 (11%) 7 (14%)
Intestine Large, Rectum (49) (50) (48) (50) (46) (50)
Parasite Metazoan 1 (2%) 1 (2%) 3 (6%) 2 (4%) 4 (8%)
Ulcer 1 (2%)
Intestine Small, Duodenum (48) (50) (49) (50) (50) (47)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Ulcer 2 (4%) 1 (2%)
Peyer's Patch, Infiltration Cellular,
Histiocyte 1 (2%)
Intestine Small, Ileum (46) (50) (46) (50) (47) (45)
Hyperplasia 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (47) (50) (47) (49) (47) (44)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Liver (50) (50) (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 2 (4%) 8 (16%) 3 (6%)
Clear Cell Focus 2 (4%) 5 (10%) 22 (44%) 13 (26%) 4 (8%)
Cytomegaly 6 (12%) 14 (28%) 49 (98%) 49 (98%) 50 (100%)
Cytoplasmic Alteration 1 (2%)
Eosinophilic Focus 1 (2%) 3 (6%) 2 (4%) 18 (36%) 16 (32%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fatty Change 2 (4%) 39 (78%) 44 (88%) 43 (86%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Necrosis, Coagulative 1 (2%) 2 (4%) 5 (10%) 18 (36%) 9 (18%) 31 (62%)
Thrombosis 1 (2%) 1 (2%) 1 (2%) 7 (14%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 9 (18%) 9 (18%) 6 (12%)
Hepatocyte, Necrosis 2 (4%) 23 (46%) 15 (30%) 4 (8%)
Sinusoid, Congestion 1 (2%)
Mesentery (2) (1) (4) (3) (2) (1)
Hyperplasia, Lymphoid 1 (50%)
Inflammation, Chronic 2 (67%) 1 (50%)
Inflammation, Necrotizing 1 (50%) 2 (50%) 1 (33%)
Pancreas (48) (50) (49) (50) (50) (48)
Hemorrhage 1 (2%)
Hypoplasia 1 (2%) 1 (2%)
Necrosis 2 (4%)
Acinus, Atrophy 1 (2%) 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Artery, Inflammation, Chronic 1 (2%) 2 (4%) 6 (13%)
Duct, Ectasia 3 (6%) 1 (2%) 4 (8%) 2 (4%)
Interlobular, Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Salivary Glands (50) (49) (49) (49) (48) (47)
Abscess 2 (4%) 1 (2%) 1 (2%)
Bacterium 2 (4%) 1 (2%)
Mucocele 1 (2%)
Stomach, Forestomach (49) (50) (47) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 2 (4%)
Stomach, Glandular (47) (49) (48) (50) (49) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Epithelium, Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (2)
Aorta, Inflammation, Chronic Active 1 (100%) 2 (100%)
Pulmonary Artery, Inflammation, Chronic 1 (100%)
Heart (50) (50) (50) (50) (50) (50)
Coronary Artery, Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%)
Myocardium, Inflammation, Acute, Multifocal 2 (4%)
Myocardium, Inflammation, Chronic, Multifocal 1 (2%) 1 (2%) 1 (2%)
Myocardium, Mineralization, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Valve, Bacterium 1 (2%)
Valve, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50) (50) (50) (50)
Subcapsular, Hyperplasia 4 (8%) 5 (10%) 1 (2%)
Adrenal Gland, Cortex (50) (49) (50) (49) (50) (50)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 3 (6%)
Hyperplasia 1 (2%) 2 (4%) 3 (6%) 1 (2%)
Zona Reticularis, Vacuolization Cytoplasmic 1 (2%) 2 (4%) 4 (8%) 1 (2%) 3 (6%)
Adrenal Gland, Medulla (50) (49) (50) (49) (50) (49)
Hyperplasia 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Pituitary Gland (48) (47) (49) (48) (47) (44)
Angiectasis 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia, Nodular 12 (25%) 16 (34%) 9 (18%) 7 (15%) 8 (17%) 4 (9%)
Thyroid Gland (49) (50) (50) (50) (50) (50)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%)
Follicle, Hyperplasia, Nodular 2 (4%) 5 (10%) 3 (6%) 6 (12%) 11 (22%) 15 (30%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (2) (1)
Abscess 1 (50%)
Ovary (47) (49) (48) (48) (49) (49)
Angiectasis 1 (2%)
Cyst 1 (2%)
Inflammation, Chronic Active 3 (6%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Bilateral, Periovarian Tissue, Cyst 2 (4%)
Follicle, Cyst 3 (6%) 3 (6%) 2 (4%) 6 (13%) 4 (8%) 2 (4%)
Periovarian Tissue, Cyst 11 (23%) 12 (24%) 8 (17%) 4 (8%) 9 (18%) 4 (8%)
Rete Ovarii, Cyst 1 (2%) 1 (2%) 3 (6%) 2 (4%) 2 (4%)
Uterus (49) (50) (49) (50) (49) (49)
Angiectasis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Dilatation 6 (12%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 46 (94%) 42 (84%) 38 (78%) 32 (64%) 24 (49%) 11 (22%)
Endometrium, Endothelium, Metaplasia,
Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50) (50)
Calvarium, Myelofibrosis 6 (12%) 21 (42%) 13 (26%) 5 (10%)
Femoral, Myelofibrosis 13 (26%) 21 (42%) 13 (26%) 9 (18%) 5 (10%) 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%)
Sternal, Myelofibrosis 42 (84%) 1 (2%) 1 (2%) 11 (22%) 11 (22%) 2 (4%)
Lymph Node (48) (49) (48) (50) (49) (47)
Lumbar, Hyperplasia, Plasma Cell 1 (2%)
Lumbar, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Mandibular, Abscess 1 (2%)
Mandibular, Bacterium 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mandibular, Infiltration Cellular, Histiocyte 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Renal, Infiltration Cellular, Histiocyte 1 (2%)
Sinus, Mandibular, Ectasia 2 (4%) 3 (6%) 1 (2%)
Lymph Node, Mesenteric (8) (21) (15) (21) (23) (20)
Hematopoietic Cell Proliferation 2 (10%) 4 (27%) 5 (24%) 8 (35%) 7 (35%)
Hyperplasia, Lymphoid 2 (25%) 3 (14%) 5 (24%) 3 (13%) 3 (15%)
Hyperplasia, Plasma Cell 1 (7%) 2 (10%) 1 (5%)
Infiltration Cellular, Histiocyte 1 (13%) 1 (7%) 1 (5%) 4 (17%)
Inflammation, Granulomatous 1 (4%)
Sinus, Ectasia 4 (50%) 10 (48%) 7 (47%) 6 (29%) 15 (65%) 13 (65%)
Spleen (48) (50) (50) (50) (50) (50)
Depletion Lymphoid 1 (2%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 2 (4%) 9 (18%) 5 (10%) 8 (16%) 23 (46%)
Hyperplasia, Lymphoid 14 (29%) 9 (18%) 2 (4%) 3 (6%) 2 (4%)
Necrosis, Acute 1 (2%)
Pigmentation 2 (4%)
Thymus (43) (43) (31) (38) (29) (27)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Amyloid Deposition 1 (3%)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50) (49) (49) (50) (50)
Acanthosis 31 (63%) 37 (74%) 28 (57%) 44 (90%) 44 (88%) 43 (86%)
Hyperkeratosis 23 (47%) 29 (58%) 28 (57%) 46 (94%) 42 (84%) 46 (92%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Necrotizing 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Parasite Metazoan 24 (49%) 28 (56%) 26 (53%) 43 (88%) 38 (76%) 41 (82%)
Subcutaneous Tissue, Granuloma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50) (50) (50)
Tarsal, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Infarct 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Cerebrum, Compression 2 (4%)
Hypothalamus, Compression 1 (2%) 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Peripheral Nerve (1)
Sciatic, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50) (50)
Hemorrhage 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Alveolus, Inflammation, Acute 1 (2%)
Artery, Thrombosis 1 (2%) 2 (4%)
Bronchus, Granuloma 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Lymphatic, Infiltration Cellular,
Polymorphonuclear 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Vein, Thrombosis 1 (2%)
Nose (50) (50) (50) (50) (49) (50)
Nerve, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Middle Ear, Abscess 1 (100%)
Middle Ear, Bacterium 1 (100%)
Harderian Gland (6) (1) (6) (2) (2) (1)
Atrophy 1 (17%)
Hyperplasia, Nodular 2 (33%) 1 (17%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (50) (50)
Cyst 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 2 (4%) 1 (2%) 1 (2%)
Mineralization 2 (4%)
Nephropathy, Chronic 3 (6%) 3 (6%) 6 (12%) 5 (10%)
Glomerulus, Inflammation,
Membranoproliferative 2 (4%)
Renal Tubule, Casts Protein 1 (2%)
Urinary Bladder (48) (50) (49) (48) (49) (49)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Natural Death 34 35
Moribund Sacrifice 16 15
Survivors
Animals Examined Microscopically 49 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (45) (45)
Parasite Metazoan 2 (4%) 5 (11%)
Intestine Large, Colon (44) (45)
Parasite Metazoan 22 (50%) 17 (38%)
Intestine Large, Rectum (45) (46)
Parasite Metazoan 2 (4%) 2 (4%)
Intestine Small, Ileum (39) (41)
Parasite Metazoan 2 (5%) 2 (5%)
Liver (48) (47)
Clear Cell Focus 1 (2%) 3 (6%)
Cyst 2 (4%)
Cytomegaly 48 (100%) 47 (100%)
Eosinophilic Focus 4 (8%) 8 (17%)
Fatty Change 46 (96%) 47 (100%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Necrosis, Coagulative 34 (71%) 20 (43%)
Thrombosis 6 (13%) 6 (13%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 40 (83%) 37 (79%)
Hepatocyte, Necrosis 10 (21%) 3 (6%)
Mesentery (1)
Inflammation, Chronic 1 (100%)
Pancreas (41) (47)
Hemorrhage 1 (2%)
Infarct 1 (2%)
Artery, Inflammation, Chronic 8 (20%) 4 (9%)
Interlobular, Inflammation, Chronic 1 (2%)
Stomach, Forestomach (45) (46)
Acanthosis 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Stomach, Glandular (44) (45)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Inflammation, Chronic Active 1 (100%)
Heart (45) (45)
Atrium, Dilatation 1 (2%)
Coronary Artery, Inflammation, Chronic 1 (2%)
Myocardium, Inflammation, Chronic, Multifocal 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (44) (47)
Subcapsular, Hyperplasia 3 (7%) 4 (9%)
Adrenal Gland, Cortex (43) (47)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Infarct 1 (2%)
Thyroid Gland (43) (44)
Follicle, Hyperplasia, Nodular 4 (9%) 9 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (45) (46)
Mineralization 1 (2%)
Follicle, Cyst 1 (2%)
Periovarian Tissue, Cyst 1 (2%) 1 (2%)
Rete Ovarii, Cyst 2 (4%)
Uterus (48) (48)
Pigmentation 1 (2%)
Endometrium, Hyperplasia, Cystic 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (42) (41)
Mandibular, Hematopoietic Cell Proliferation 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Pancreatic, Sinus, Ectasia 1 (2%)
Sinus, Mandibular, Ectasia 1 (2%) 1 (2%)
Lymph Node, Mesenteric (7) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hematopoietic Cell Proliferation 2 (29%) 8 (80%)
Infiltration Cellular, Histiocyte 1 (14%)
Sinus, Ectasia 5 (71%) 2 (20%)
Spleen (44) (47)
Hematopoietic Cell Proliferation 37 (84%) 29 (62%)
Hyperplasia, Lymphoid 1 (2%)
Pigmentation 1 (2%)
Thymus (20) (32)
Ectopic Parathyroid Gland 1 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (47)
Acanthosis 38 (78%) 30 (64%)
Hyperkeratosis 39 (80%) 33 (70%)
Parasite Metazoan 33 (67%) 31 (66%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (46) (44)
Inflammation, Chronic 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Hyperplasia, Nodular 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (46) (49)
Metaplasia, Osseous 1 (2%)
Nephropathy, Chronic 16 (35%) 29 (59%)
Glomerulus, Inflammation,
Membranoproliferative 1 (2%)
Glomerulus, Nephropathy, Chronic 2 (4%)
Urinary Bladder (45) (47)
Parasite Metazoan 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 49 50 50 50
Early Deaths
Moribund Sacrifice 9 5 2 5 2 3
Natural Death 10 13 5 11 14 18
Survivors
Terminal Sacrifice 31 32 41 34 33 27
Natural Death 1 1 2
Animals Examined Microscopically 50 50 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (38) (43) (45) (43) (39) (36)
Epithelium, Hyperplasia 1 (3%) 1 (2%)
Epithelium, Inclusion Body Intracytoplasmic 2 (5%) 1 (2%)
Lumen, Crystals 1 (2%)
Intestine Large, Cecum (47) (49) (44) (49) (49) (48)
Parasite Metazoan 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Ulcer 1 (2%) 2 (4%)
Intestine Large, Colon (47) (49) (46) (49) (50) (49)
Parasite Metazoan 1 (2%) 2 (4%) 2 (4%) 4 (8%) 9 (18%) 14 (29%)
Intestine Large, Rectum (50) (49) (44) (48) (48) (47)
Parasite Metazoan 3 (6%) 4 (8%) 1 (2%) 4 (8%) 5 (10%) 2 (4%)
Intestine Small, Duodenum (49) (49) (45) (49) (49) (47)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Ileum (47) (47) (45) (46) (49) (43)
Parasite Metazoan 2 (4%) 2 (4%) 2 (5%)
Ulcer 1 (2%) 2 (4%)
Intestine Small, Jejunum (48) (45) (47) (46) (48) (47)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 2 (4%)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Liver (50) (50) (48) (49) (49) (50)
Abscess 1 (2%)
Amyloid Deposition 1 (2%)
Bacterium 1 (2%)
Basophilic Focus 2 (4%) 6 (12%) 1 (2%) 3 (6%) 7 (14%) 8 (16%)
Clear Cell Focus 13 (26%) 15 (31%) 8 (16%) 8 (16%) 5 (10%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Cytologic Alterations 21 (42%)
Cytomegaly 36 (72%) 44 (92%) 49 (100%) 48 (98%) 48 (96%)
Eosinophilic Focus 3 (6%) 20 (40%) 8 (17%) 16 (33%) 4 (8%)
Fatty Change 2 (4%) 2 (4%) 4 (8%) 45 (92%) 43 (88%) 40 (80%)
Granuloma 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Necrosis, Coagulative 1 (2%) 9 (18%) 5 (10%) 17 (35%) 16 (33%) 23 (46%)
Parasite Metazoan 1 (2%)
Thrombosis 6 (12%) 1 (2%) 3 (6%) 1 (2%) 6 (12%)
Bile Duct, Dilatation 1 (2%)
Bile Duct, Hyperplasia 8 (16%)
Hepatocyte, Necrosis 3 (6%) 3 (6%) 4 (8%) 1 (2%) 4 (8%)
Oval Cell, Hyperplasia 2 (4%)
Oval Cell, Proliferation 1 (2%)
Mesentery (5) (3) (2)
Inflammation, Acute 1 (20%)
Inflammation, Chronic 1 (20%) 1 (33%) 2 (100%)
Inflammation, Necrotizing 2 (40%)
Pancreas (50) (50) (47) (49) (49) (48)
Necrosis 1 (2%)
Acinus, Atrophy 1 (2%) 2 (4%)
Artery, Inflammation, Chronic 1 (2%) 2 (4%) 2 (4%)
Duct, Ectasia 1 (2%) 1 (2%)
Interlobular, Inflammation, Chronic 1 (2%) 1 (2%)
Salivary Glands (50) (49) (49) (49) (50) (49)
Abscess 1 (2%)
Bacterium 1 (2%)
Duct, Fibrosis 1 (2%)
Stomach, Forestomach (48) (49) (47) (50) (49) (47)
Acanthosis 2 (4%) 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Necrotizing 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (48) (48) (47) (50) (49) (47)
Ectopic Tissue 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Mucosa, Mineralization 1 (2%)
Tooth (4) (4) (3) (6) (1)
Gingiva, Inflammation, Chronic Active 2 (50%) 2 (50%) 1 (17%)
Pulp, Inflammation, Chronic Active 2 (50%) 2 (50%) 2 (67%) 4 (67%) 1 (100%)
Pulp, Inflammation, Suppurative 1 (33%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (49) (50) (50) (50)
Ectopic Tissue 1 (2%)
Coronary Artery, Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Epicardium, Inflammation, Chronic 2 (4%)
Myocardium, Inflammation, Chronic, Multifocal 1 (2%) 2 (4%) 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Myocardium, Mineralization, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (39) (50) (48) (49) (50) (50)
Subcapsular, Hyperplasia 4 (10%) 3 (6%) 1 (2%) 1 (2%)
Adrenal Gland, Cortex (39) (50) (47) (49) (50) (50)
Amyloid Deposition 1 (2%)
Hyperplasia 1 (3%) 3 (6%) 1 (2%) 2 (4%)
Hypertrophy 1 (2%)
Infarct 1 (3%)
Zona Glomerulosa, Cytoplasmic Alteration 1 (3%)
Adrenal Gland, Medulla (38) (50) (47) (49) (49) (50)
Hyperplasia 2 (5%) 2 (4%) 2 (4%) 1 (2%)
Islets, Pancreatic (48) (49) (46) (48) (48) (45)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (44) (44) (45) (46) (44) (41)
Pars Distalis, Hyperplasia, Nodular 2 (5%)
Thyroid Gland (50) (49) (47) (49) (48) (48)
Inflammation, Chronic 1 (2%)
Follicle, Hyperplasia, Nodular 3 (6%) 16 (33%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (48) (50) (49) (50)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Chronic Active 1 (2%)
Preputial Gland (3) (1) (1) (2)
Abscess 2 (67%) 1 (100%) 2 (100%)
Duct, Dilatation 1 (33%) 1 (100%)
Prostate (50) (50) (48) (49) (49) (49)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Serosa, Inflammation, Necrotizing 1 (2%)
Testes (50) (50) (49) (50) (49) (50)
Seminiferous Tubule, Atrophy 1 (2%) 1 (2%) 1 (2%)
Seminiferous Tubule, Hypospermia 1 (2%)
Tunic, Inflammation, Necrotizing 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (49) (50) (49)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (48) (50) (48) (48) (48) (46)
Deep Cervical, Hyperplasia, Plasma Cell 1 (2%)
Deep Cervical, Sinus, Ectasia 1 (2%)
Lumbar, Hyperplasia, Plasma Cell 1 (2%)
Mandibular, Abscess 1 (2%) 1 (2%) 1 (2%)
Mandibular, Bacterium 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Mandibular, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Sinus, Ectasia 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Sinus, Mandibular, Ectasia 1 (2%) 1 (2%)
Lymph Node, Mesenteric (32) (34) (34) (37) (35) (31)
Angiectasis 1 (3%)
Hematopoietic Cell Proliferation 13 (41%) 12 (35%) 14 (41%) 20 (54%) 13 (37%) 14 (45%)
Hyperplasia, Lymphoid 1 (3%) 8 (24%) 8 (22%) 5 (14%) 2 (6%)
Hyperplasia, Plasma Cell 1 (3%) 1 (3%)
Infiltration Cellular, Histiocyte 4 (12%) 6 (18%) 8 (22%) 9 (26%) 2 (6%)
Inflammation, Granulomatous 1 (3%) 1 (3%)
Artery, Thrombosis 1 (3%)
Sinus, Ectasia 9 (28%) 18 (53%) 16 (47%) 14 (38%) 19 (54%) 24 (77%)
Spleen (50) (50) (47) (49) (50) (48)
Amyloid Deposition 1 (2%) 1 (2%)
Depletion Lymphoid 1 (2%) 2 (4%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 9 (18%) 1 (2%) 8 (16%) 8 (16%) 11 (23%)
Hyperplasia, Lymphoid 3 (6%) 2 (4%) 7 (15%) 5 (10%) 2 (4%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (2) (1)
Duct, Ectasia 1 (50%)
Skin (50) (50) (49) (49) (50) (49)
Abscess 1 (2%)
Acanthosis 29 (58%) 35 (70%) 32 (65%) 38 (78%) 38 (76%) 31 (63%)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 24 (48%) 35 (70%) 29 (59%) 37 (76%) 38 (76%) 33 (67%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Necrotizing 2 (4%)
Parasite Metazoan 23 (46%) 35 (70%) 29 (59%) 36 (73%) 36 (72%) 29 (59%)
Ulcer 1 (2%)
Dermis, Metaplasia, Osseous 1 (2%)
Sebaceous Gland, Ectasia 1 (2%)
Subcutaneous Tissue, Fat, Necrosis 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (49) (50) (50) (50)
Coccygeal, Fracture Healed 1 (2%)
Femur, Osteopetrosis 1 (2%)
Tarsal, Hyperostosis 5 (10%) 5 (10%) 10 (20%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50) (50) (49)
Bacterium 1 (2%)
Inflammation, Acute 1 (2%)
Hypothalamus, Compression 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50) (50) (50)
Abscess 1 (2%)
Bacterium 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 2 (4%) 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Alveolus, Inflammation, Acute 2 (4%)
Artery, Thrombosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Bronchus, Foreign Body 1 (2%)
Interstitium, Inflammation, Chronic 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Synechia 1 (100%)
Anterior Chamber, Inflammation, Suppurative 1 (100%)
Harderian Gland (3) (4) (5) (1) (1) (3)
Hyperplasia, Nodular 1 (100%)
Inflammation, Necrotizing 1 (33%)
Duct, Dilatation 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50) (49) (48)
Abscess 1 (2%)
Bacterium 1 (2%)
Cyst 6 (12%) 3 (6%) 1 (2%) 4 (8%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Acute 1 (2%)
Metaplasia, Osseous 2 (4%) 3 (6%)
Nephropathy, Chronic 9 (18%) 8 (16%) 8 (16%) 10 (20%) 11 (22%) 5 (10%)
Artery, Inflammation, Subacute 1 (2%)
Glomerulus, Amyloid Deposition 1 (2%)
Glomerulus, Inflammation,
Membranoproliferative 1 (2%) 2 (4%)
Glomerulus, Nephropathy, Chronic 1 (2%)
Urinary Bladder (49) (50) (48) (48) (48) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Parasite Metazoan 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Natural Death 34 29
Moribund Sacrifice 16 21
Survivors
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (41) (32)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Cecum (43) (49)
Cyst 1 (2%)
Parasite Metazoan 2 (5%) 1 (2%)
Intestine Large, Colon (50) (49)
Parasite Metazoan 23 (46%) 20 (41%)
Ulcer 1 (2%)
Intestine Large, Rectum (47) (49)
Parasite Metazoan 3 (6%) 3 (6%)
Intestine Small, Duodenum (50) (47)
Ulcer 1 (2%)
Epithelium, Metaplasia, Squamous 1 (2%)
Intestine Small, Ileum (39) (40)
Parasite Metazoan 3 (8%) 1 (3%)
Intestine Small, Jejunum (43) (47)
Parasite Metazoan 1 (2%)
Liver (50) (50)
Basophilic Focus 1 (2%) 7 (14%)
Clear Cell Focus 1 (2%) 2 (4%)
Cytomegaly 50 (100%) 50 (100%)
Eosinophilic Focus 6 (12%) 4 (8%)
Fatty Change 50 (100%) 48 (96%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Acute 1 (2%)
Necrosis, Coagulative 24 (48%) 29 (58%)
Thrombosis 8 (16%) 7 (14%)
Bile Duct, Hyperplasia 34 (68%) 26 (52%)
Hepatocyte, Necrosis 2 (4%) 3 (6%)
Vein, Inflammation, Subacute 1 (2%)
Pancreas (49) (49)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infarct 3 (6%) 1 (2%)
Acinus, Atrophy 1 (2%)
Artery, Inflammation, Chronic 8 (16%) 1 (2%)
Duct, Ectasia 1 (2%)
Salivary Glands (46) (47)
Abscess 1 (2%)
Bacterium 1 (2%)
Stomach, Forestomach (50) (50)
Acanthosis 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Hyperkeratosis 2 (4%)
Stomach, Glandular (50) (50)
Hemorrhage 1 (2%)
Mucosa, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (2)
Aorta, Inflammation, Chronic Active 2 (67%) 2 (100%)
Aorta, Thrombosis 1 (33%)
Heart (50) (46)
Necrosis 1 (2%)
Coronary Artery, Inflammation, Chronic 1 (2%)
Myocardium, Inflammation, Chronic, Multifocal 3 (6%)
Valve, Inflammation, Chronic Active 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (46)
Subcapsular, Hyperplasia 1 (2%)
Adrenal Gland, Cortex (48) (46)
Hyperplasia 1 (2%)
Infarct 1 (2%) 1 (2%)
Adrenal Gland, Medulla (49) (46)
Hyperplasia 3 (6%)
Infarct 1 (2%)
Thyroid Gland (46) (45)
Follicle, Hyperplasia 1 (2%)
Follicle, Hyperplasia, Nodular 8 (17%) 9 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50)
Granuloma Sperm 1 (2%)
Preputial Gland (1)
Duct, Dilatation 1 (100%)
Prostate (50) (47)
Inflammation, Suppurative 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Femoral, Myelofibrosis 2 (4%)
Myeloid Cell, Hyperplasia 3 (6%) 1 (2%)
Lymph Node (44) (42)
Hyperplasia, Lymphoid 1 (2%)
Mandibular, Abscess 1 (2%)
Mandibular, Fibrosis 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%)
Mandibular, Infiltration Cellular, Histiocyte 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (2%)
Sinus, Mandibular, Ectasia 1 (2%)
Lymph Node, Mesenteric (11) (10)
Hematopoietic Cell Proliferation 3 (27%) 4 (40%)
Sinus, Ectasia 7 (64%) 6 (60%)
Spleen (49) (48)
Hematopoietic Cell Proliferation 41 (84%) 32 (67%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (49)
Acanthosis 26 (52%) 31 (63%)
Erosion 1 (2%)
Hyperkeratosis 29 (58%) 34 (69%)
Parasite Metazoan 18 (36%) 21 (43%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (46)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%)
Alveolus, Inflammation, Acute 1 (2%)
Bronchus, Metaplasia, Squamous 1 (2%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49)
Inflammation, Acute 1 (2%)
Nephropathy, Chronic 44 (88%) 29 (59%)
Artery, Inflammation, Subacute 2 (4%)
Fat, Necrosis 1 (2%)
Glomerulus, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Glomerulus, Inflammation,
Membranoproliferative 1 (2%) 1 (2%)
Urinary Bladder (47) (47)
Inflammation, Chronic Active 1 (2%)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
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