TDMS Study 05077-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
NTP Experiment-Test: 05077-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
Facility: Battelle Columbus Laboratory
Chemical CAS #: 67774327
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 7 3 5 2 4 8
Natural Death 4 2 13 10 13 25
Survivors
Terminal Sacrifice 39 45 32 38 33 17
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (50) (45) (46) (38) (45)
Intestine Large, Cecum (47) (50) (49) (50) (46) (50)
Intestine Large, Rectum (49) (50) (48) (50) (46) (50)
Intestine Small, Duodenum (48) (50) (49) (50) (50) (47)
Adenoma 1 (2%)
Intestine Small, Ileum (46) (50) (46) (50) (47) (45)
Intestine Small, Jejunum (47) (50) (47) (49) (47) (44)
Adenocarcinoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Liver (50) (50) (50) (50) (50) (50)
Hemangiosarcoma 1 (2%) 1 (2%) 3 (6%)
Hemangiosarcoma, Single 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Carcinoma, Multiple 8 (16%) 13 (26%) 22 (44%)
Hepatocellular Carcinoma, Single 1 (2%) 4 (8%) 2 (4%) 14 (28%) 13 (26%) 21 (42%)
Hepatocellular Adenoma, Multiple 1 (2%) 7 (14%) 28 (56%) 31 (62%) 44 (88%)
Hepatocellular Adenoma, Single 3 (6%) 12 (24%) 6 (12%) 11 (22%) 7 (14%) 3 (6%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Mesentery (2) (1) (4) (3) (2) (1)
Hemangioma 1 (25%)
Pancreas (48) (50) (49) (50) (50) (48)
Stomach, Forestomach (49) (50) (47) (50) (50) (50)
Squamous Cell Papilloma 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Stomach, Glandular (47) (49) (48) (50) (49) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50) (50) (50) (50)
Capsule, Histiocytic Sarcoma 1 (2%)
Adrenal Gland, Cortex (50) (49) (50) (49) (50) (50)
Adrenal Gland, Medulla (50) (49) (50) (49) (50) (49)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (48) (49) (47) (50) (47) (43)
Adenoma 1 (2%)
Pituitary Gland (48) (47) (49) (48) (47) (44)
Pars Distalis, Adenoma 5 (10%) 6 (13%) 10 (20%) 10 (21%) 11 (23%) 3 (7%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (50) (50) (50) (50) (50)
Bilateral, Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicle, Adenoma 1 (2%)
Follicular Cell, Adenoma 2 (4%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (2) (1)
Carcinoma 1 (50%) 1 (100%)
Ovary (47) (49) (48) (48) (49) (49)
Cystadenoma 1 (2%)
Granulosa Cell Tumor Benign 2 (4%) 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Luteoma 1 (2%) 1 (2%) 2 (4%)
Mixed Tumor Benign 1 (2%) 1 (2%)
Osteosarcoma, Metastatic 1 (2%)
Thecoma Benign 1 (2%)
Oviduct (1) (2)
Uterus (49) (50) (49) (50) (49) (49)
Adenocarcinoma 1 (2%)
Hamartoma 1 (2%)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 1 (2%) 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (50) (50)
Femoral, Hemangiosarcoma 3 (6%) 1 (2%) 2 (4%)
Femoral, Histiocytic Sarcoma 1 (2%)
Sternal, Hemangiosarcoma 2 (4%)
Sternal, Histiocytic Sarcoma 1 (2%)
Lymph Node (48) (49) (48) (50) (49) (47)
Mandibular, Histiocytic Sarcoma 1 (2%)
Mediastinal, Carcinoma, Metastatic 1 (2%)
Mediastinal, Histiocytic Sarcoma 1 (2%) 1 (2%)
Pancreatic, Histiocytic Sarcoma 1 (2%)
Renal, Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymph Node, Mesenteric (8) (21) (15) (21) (23) (20)
Histiocytic Sarcoma 1 (5%) 1 (7%) 1 (5%)
Spleen (48) (50) (50) (50) (50) (50)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Thymus (43) (43) (31) (38) (29) (27)
Histiocytic Sarcoma 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (41) (44) (34) (32) (37) (26)
Adenocarcinoma 2 (6%) 1 (3%)
Skin (49) (50) (49) (49) (50) (50)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50) (50) (50)
Osteoma 1 (2%)
Osteosarcoma 1 (2%) 1 (2%)
Skeletal Muscle (1) (1) (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50) (50)
Peripheral Nerve (1)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma, Single 2 (4%) 2 (4%) 2 (4%) 1 (2%) 3 (6%)
Alveolar/Bronchiolar Carcinoma, Single 1 (2%) 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 2 (4%) 3 (6%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50) (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Harderian Gland (6) (1) (6) (2) (2) (1)
Adenoma 3 (50%) 1 (100%) 4 (67%) 2 (100%) 2 (100%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Urinary Bladder (48) (50) (49) (48) (49) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%) 3 (6%) 2 (4%) 2 (4%)
Lymphoma Malignant Lymphocytic 2 (4%) 2 (4%) 4 (8%) 2 (4%) 2 (4%) 2 (4%)
Lymphoma Malignant Mixed 3 (6%) 2 (4%) 3 (6%) 3 (6%) 2 (4%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 3 (6%) 6 (12%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 25 35 36 46 49 50
Total Primary Neoplasms 33 51 64 102 101 111
Total Animals with Benign Neoplasms 16 28 22 39 42 47
Total Benign Neoplasms 18 37 28 59 59 59
Total Animals with Malignant Neoplasms 13 13 26 31 32 45
Total Malignant Neoplasms 15 14 36 43 42 52
Total Animals with Metastatic Neoplasms 1 1 2 2 4
Total Metastatic Neoplasm 1 2 2 2 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Natural Death 34 35
Moribund Sacrifice 16 15
Survivors
Animals Examined Microscopically 49 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (48) (47)
Hepatocellular Carcinoma, Multiple 21 (44%) 9 (19%)
Hepatocellular Carcinoma, Single 14 (29%) 20 (43%)
Hepatocellular Adenoma, Multiple 41 (85%) 36 (77%)
Hepatocellular Adenoma, Single 5 (10%) 5 (11%)
Stomach, Forestomach (45) (46)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Medulla (43) (47)
Pheochromocytoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (45) (46)
Teratoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (47)
Subcutaneous Tissue, Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (46) (44)
Alveolar/Bronchiolar Adenoma, Single 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 4 (9%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 8
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 47
Total Primary Neoplasms 84 73
Total Animals with Benign Neoplasms 46 41
Total Benign Neoplasms 49 44
Total Animals with Malignant Neoplasms 35 29
Total Malignant Neoplasms 35 29
Total Animals with Metastatic Neoplasms 1 4
Total Metastatic Neoplasm 1 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 9
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 49 50 50 50
Early Deaths
Moribund Sacrifice 9 5 2 5 2 3
Natural Death 10 13 5 11 14 18
Survivors
Terminal Sacrifice 31 32 41 34 33 27
Natural Death 1 1 2
Animals Examined Microscopically 50 50 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49) (50) (50) (49)
Gallbladder (38) (43) (45) (43) (39) (36)
Intestine Large, Cecum (47) (49) (44) (49) (49) (48)
Intestine Large, Rectum (50) (49) (44) (48) (48) (47)
Intestine Small, Duodenum (49) (49) (45) (49) (49) (47)
Adenoma 1 (2%)
Intestine Small, Ileum (47) (47) (45) (46) (49) (43)
Intestine Small, Jejunum (48) (45) (47) (46) (48) (47)
Adenocarcinoma 1 (2%)
Liver (50) (50) (48) (49) (49) (50)
Fibrosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Hemangiosarcoma 3 (6%) 5 (10%) 3 (6%) 4 (8%) 3 (6%) 2 (4%)
Hemangiosarcoma, Single 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Multiple 4 (8%) 6 (12%) 2 (4%) 13 (27%) 14 (29%) 21 (42%)
Hepatocellular Carcinoma, Single 4 (8%) 11 (22%) 6 (13%) 16 (33%) 17 (35%) 18 (36%)
Hepatocellular Adenoma, Multiple 1 (2%) 22 (44%) 12 (25%) 48 (98%) 41 (84%) 42 (84%)
Hepatocellular Adenoma, Single 8 (16%) 9 (18%) 18 (38%) 5 (10%) 6 (12%)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%)
Ito Cell Tumor Malignant, Multiple 1 (2%)
Sarcoma 2 (4%) 1 (2%) 1 (2%)
Mesentery (5) (3) (2)
Pancreas (50) (50) (47) (49) (49) (48)
Salivary Glands (50) (49) (49) (49) (50) (49)
Stomach, Forestomach (48) (49) (47) (50) (49) (47)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (48) (48) (47) (50) (49) (47)
Adenoma 1 (2%)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
Tooth (4) (4) (3) (6) (1)
Page 10
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (49) (50) (50) (50)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (39) (50) (48) (49) (50) (50)
Adrenal Gland, Cortex (39) (50) (47) (49) (50) (50)
Adrenal Gland, Medulla (38) (50) (47) (49) (49) (50)
Pheochromocytoma Benign 2 (5%) 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%)
Parathyroid Gland (45) (48) (46) (48) (47) (45)
Pituitary Gland (44) (44) (45) (46) (44) (41)
Pars Distalis, Adenoma 1 (2%)
Thyroid Gland (50) (49) (47) (49) (48) (48)
Follicular Cell, Adenoma 1 (2%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (48) (50) (49) (50)
Prostate (50) (50) (48) (49) (49) (49)
Seminal Vesicle (1) (1) (2)
Testes (50) (50) (49) (50) (49) (50)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (49) (50) (49)
Femoral, Hemangiosarcoma 2 (4%) 2 (4%)
Sternal, Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Lymph Node (48) (50) (48) (48) (48) (46)
Lymph Node, Mesenteric (32) (34) (34) (37) (35) (31)
Histiocytic Sarcoma 1 (3%) 1 (3%) 1 (3%)
Spleen (50) (50) (47) (49) (50) (48)
Hemangiosarcoma 3 (6%) 2 (4%) 5 (11%) 3 (6%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Page 11
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (29) (40) (40) (37) (29) (25)
Thymoma Benign 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (49) (50) (49)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 2 (4%)
Subcutaneous Tissue, Sarcoma 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50) (50) (49)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50) (50) (50)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 3 (6%) 3 (6%) 3 (6%) 2 (4%)
Alveolar/Bronchiolar Adenoma, Single 9 (18%) 8 (16%) 8 (16%) 6 (12%) 11 (22%) 10 (20%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Single 2 (4%) 2 (4%) 1 (2%)
Hepatoblastoma, Metastatic, Uncertain
Primary Site 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (2%) 1 (2%) 2 (4%) 4 (8%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 4 (8%) 3 (6%) 2 (4%) 5 (10%)
Histiocytic Sarcoma 1 (2%)
Nose (50) (50) (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (4) (5) (1) (1) (3)
Adenoma 2 (67%) 3 (75%) 5 (100%) 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50) (49) (48)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hepatoblastoma, Metastatic, Uncertain
Primary Site 1 (2%)
Histiocytic Sarcoma 1 (2%)
Urinary Bladder (49) (50) (48) (48) (48) (50)
Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(49) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 3 (6%) 3 (6%) 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%) 1 (2%) 1 (2%)
Lymphoma Malignant Undifferentiated Cell 6 (12%) 5 (10%) 6 (12%) 4 (8%) 8 (16%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 13
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 37 47 42 48 47 49
Total Primary Neoplasms 59 91 76 111 112 115
Total Animals with Benign Neoplasms 21 37 37 48 47 48
Total Benign Neoplasms 26 47 50 59 62 68
Total Animals with Malignant Neoplasms 23 29 20 34 37 44
Total Malignant Neoplasms 33 44 26 52 50 47
Total Animals with Metastatic Neoplasms 3 5 1 3 4 9
Total Metastatic Neoplasm 3 7 1 3 4 9
Total Animals with Malignant Neoplasms 2
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 14
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Natural Death 34 29
Moribund Sacrifice 16 21
Survivors
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (50)
Hepatocellular Carcinoma, Multiple 22 (44%) 17 (34%)
Hepatocellular Carcinoma, Single 14 (28%) 18 (36%)
Hepatocellular Adenoma 1 (2%)
Hepatocellular Adenoma, Multiple 37 (74%) 43 (86%)
Hepatocellular Adenoma, Single 4 (8%) 5 (10%)
Stomach, Forestomach (50) (50)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (46)
Thyroid Gland (46) (45)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 15
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mesenteric (11) (10)
Spleen (49) (48)
Hemangiosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (46)
Alveolar/Bronchiolar Adenoma, Single 1 (2%) 3 (7%)
Alveolar/Bronchiolar Carcinoma, Single 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic 5 (10%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 5 (11%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Lymphoma Malignant Lymphocytic 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 16
NTP Experiment-Test: 05077-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 09:16:37
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 50
Total Primary Neoplasms 85 91
Total Animals with Benign Neoplasms 42 48
Total Benign Neoplasms 45 54
Total Animals with Malignant Neoplasms 37 35
Total Malignant Neoplasms 40 37
Total Animals with Metastatic Neoplasms 6 6
Total Metastatic Neoplasm 6 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 17
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