TDMS Study 05077-02 Pathology Tables
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
Facility: Battelle Columbus Laboratory
Chemical CAS #: 67774-32-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 7| 9| 3| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 1| 2| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + A + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Mixed Cell | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Mesentery | + + |
Hyperplasia, Lymphoid | 2 |
Inflammation, Necrotizing | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 4 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 7| 9| 3| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 1| 2| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Valve, Bacterium | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Zona Reticularis, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Hyperplasia, Nodular | 2 2 1 1 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | X X X X X|
Rete Ovarii, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 3 2 3 2 3 4 3 2 3 3 4 2 3 1 3 4 4 3 3 3 4 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 2 2 2 1 |
Femoral, Myelofibrosis | 1 2 1 1 1 1 |
Sternal, Myelofibrosis | 2 2 3 1 1 2 1 2 2 2 2 2 2 2 2 2 3 2 2 1 4 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Infiltration Cellular, | |
Histiocyte | 3|
Mandibular, Infiltration Cellular, | |
Histiocyte | 3|
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 7| 9| 3| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 1| 2| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 3 |
Sinus, Ectasia | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 1 2 2 2 2 3 3|
__________________________________________________________________________|
Thymus | M + + + + + + + + M + + + + + + + M + + + + + + M|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + + + + M + + + M + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Parasite Metazoan | X X X X X X X X X X X X X X X|
Subcutaneous Tissue, Granuloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Infarct | |
Hypothalamus, Compression | 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 2| 3| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 7| 9| 3| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 1| 2| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 2 |
Infiltration Cellular, Mixed Cell | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| |
| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3| 3| 3| 6| 6| 6| 7| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + + + + A + + + + + + + + + A + + +| 45 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X| 1 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + + A + + +| 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | 3 | 1 3.0|
Clear Cell Focus | X | 2 |
Eosinophilic Focus | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Necrotizing | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Hypoplasia | | 1 4.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 4 | 2 4.0|
Bacterium | X X | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| |
| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3| 3| 3| 6| 6| 6| 7| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | 2 | 1 2.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Valve, Bacterium | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hyperplasia | 1 | 1 1.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia, Nodular | 1 1 3 2 2 1 2 | 12 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Follicle, Hyperplasia, Nodular | 4 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | A + + + + + + + + + + A + + + + + + + + + M + + +| 47 |
Cyst | 2 | 1 2.0|
Follicle, Cyst | X | 3 |
Periovarian Tissue, Cyst | X X X X X X | 11 |
Rete Ovarii, Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Endometrium, Hyperplasia, Cystic | 3 3 3 4 3 4 3 4 2 3 3 3 3 2 2 3 2 3 3 2 4 3| 46 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| |
| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3| 3| 3| 6| 6| 6| 7| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Calvarium, Myelofibrosis | 1 2 | 6 1.7|
Femoral, Myelofibrosis | 1 2 1 1 1 1 1 | 13 1.2|
Sternal, Myelofibrosis | 2 2 2 3 1 1 2 1 1 2 3 2 3 2 1 2 2 3 2 3| 42 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + + M + + +| 48 |
Lumbar, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Mandibular, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 8 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Sinus, Ectasia | 1 2 | 4 1.3|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 3 1 | 4 2.0|
Hyperplasia, Lymphoid | 2 2 1 2 2 3 2 | 14 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + A + + + + + M + + + M + + +| 43 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + + + + + M + + + M + + + + + + + M +| 41 |
__________________________________________________________________________|____________|
Skin | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1| 23 1.0|
Parasite Metazoan | X X X X X X X X X| 24 |
Subcutaneous Tissue, Granuloma | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Infarct | 3 | 1 3.0|
Hypothalamus, Compression | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| |
| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3| 3| 3| 6| 6| 6| 7| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Sciatic, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitium, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 6 |
Hyperplasia, Nodular | 1 | 2 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 2 2.5|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Cytomegaly | 1 1 1 1 1 |
Cytoplasmic Alteration | 2 |
Eosinophilic Focus | 2 X |
Necrosis, Coagulative | 1 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
Duct, Ectasia | 4 4|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Zona Reticularis, Vacuolization | |
Cytoplasmic | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Nodular | 1 4 4 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Subacute | |
Follicle, Hyperplasia, Nodular | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Bilateral, Periovarian Tissue, Cyst | X |
Follicle, Cyst | |
Periovarian Tissue, Cyst | X X X X X X X |
Rete Ovarii, Cyst | X |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 |
Endometrium, Hyperplasia, Cystic | 3 4 4 1 2 3 1 3 3 4 4 2 2 3 3 1 1 3 4 4 1 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 1 2 2 2 2 2 3 1 1 1|
Femoral, Myelofibrosis | 1 1 2 1 2 2 2 1|
Myeloid Cell, Hyperplasia | 3 |
Sternal, Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Sinus, Mandibular, Ectasia | 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 4|
Sinus, Ectasia | 2 3 1 2 3 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | M + M + + + + + + + + + M + + + + M + M + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperkeratosis | 1 1 2 1 1 1 1 1 1 |
Inflammation, Necrotizing | 3 3 |
Parasite Metazoan | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 0| 3| 2| |
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 6| 6| 2| 6| 6| 6| 6| 8| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X| 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X| 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X 1 X | 5 1.0|
Cytomegaly | 1 | 6 1.0|
Cytoplasmic Alteration | | 1 2.0|
Eosinophilic Focus | 2 | 3 2.0|
Necrosis, Coagulative | 2 | 2 1.5|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 4 1 | 3 3.0|
Duct, Ectasia | 4 | 3 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcapsular, Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 | 2 1.5|
Zona Reticularis, Vacuolization | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 0| 3| 2| |
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 6| 6| 2| 6| 6| 6| 6| 8| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cytoplasmic | 4 | 2 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + + M + + + + + + +| 47 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Nodular | 1 2 1 3 2 2 3 3 2 | 16 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 2 1.5|
Inflammation, Subacute | 1 | 1 1.0|
Follicle, Hyperplasia, Nodular | 2 1 4 1 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Mineralization | | 1 2.0|
Bilateral, Periovarian Tissue, Cyst | X | 2 |
Follicle, Cyst | X X X | 3 |
Periovarian Tissue, Cyst | X X X X X | 12 |
Rete Ovarii, Cyst | | 1 |
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 4 2 | 6 3.2|
Endometrium, Hyperplasia, Cystic | 2 4 3 3 3 3 4 4 2 2 3 4 1 2 2 2 1 2 1 2 | 42 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Myelofibrosis | 2 2 2 2 2 2 1 1 1 1 2 | 21 1.7|
Femoral, Myelofibrosis | 1 2 1 2 1 2 1 1 2 2 1 1 1 | 21 1.4|
Myeloid Cell, Hyperplasia | | 1 3.0|
Sternal, Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Sinus, Mandibular, Ectasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + +| 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 0| 3| 2| |
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 6| 6| 2| 6| 6| 6| 6| 8| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hyperplasia, Lymphoid | 2 2 | 3 2.7|
Sinus, Ectasia | 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3| 2 3.0|
Hyperplasia, Lymphoid | 2 2 2 3 2 | 9 2.1|
Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + M + + + + + + + + +| 43 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + + M + + + + + + + + + + M + +| 44 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.1|
Hyperkeratosis | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.1|
Inflammation, Necrotizing | | 2 3.0|
Parasite Metazoan | X X X X X X X X X X X X X X X X X| 28 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | +| 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Hypothalamus, Compression | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 0| 3| 2| |
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 6| 6| 2| 6| 6| 6| 6| 8| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infarct | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 3| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 1| 2| 2| 9| 0| 2| 8| 2| 2| 2| 2| 3| 3| 2| 8| 3| 3| 4| 3| 3| 2| 1| 0| 3| 3|
| 0| 9| 9| 2| 9| 9| 7| 9| 9| 7| 9| 0| 0| 1| 0| 0| 0| 1| 0| 0| 6| 2| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + M + + + + + + + + + + +|
Epithelium, Inclusion Body | |
Intracytoplasmic | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Ulcer | 4 |
Peyer's Patch, Infiltration Cellular,| |
Histiocyte | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + M + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | 1 1 2 1 1 1 |
Eosinophilic Focus | X 2 |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 1 |
Necrosis, Coagulative | 3 1 1|
Hepatocyte, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Necrotizing | 2 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 3 |
Duct, Ectasia | 3 |
Interlobular, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Pulmonary Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 3| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 1| 2| 2| 9| 0| 2| 8| 2| 2| 2| 2| 3| 3| 2| 8| 3| 3| 4| 3| 3| 2| 1| 0| 3| 3|
| 0| 9| 9| 2| 9| 9| 7| 9| 9| 7| 9| 0| 0| 1| 0| 0| 0| 1| 0| 0| 6| 2| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Inflammation, | |
Chronic | |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
Valve, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia | 1 1 |
Zona Reticularis, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Nodular | 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Follicle, Hyperplasia, Nodular | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Abscess | |
__________________________________________________________________________|
Ovary | + + + M + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Chronic Active | 4 3 |
Thrombosis | |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X X |
Rete Ovarii, Cyst | X X X|
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Acute | 3 2 |
Inflammation, Granulomatous | |
Endometrium, Hyperplasia, Cystic | 2 3 4 1 2 2 2 2 2 1 2 1 2 2 2 3 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 3| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 1| 2| 2| 9| 0| 2| 8| 2| 2| 2| 2| 3| 3| 2| 8| 3| 3| 4| 3| 3| 2| 1| 0| 3| 3|
| 0| 9| 9| 2| 9| 9| 7| 9| 9| 7| 9| 0| 0| 1| 0| 0| 0| 1| 0| 0| 6| 2| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 1 2 1 1 2 |
Femoral, Myelofibrosis | 1 2 1 1 2 |
Sternal, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Plasma Cell | 3 |
Lumbar, Infiltration Cellular, | |
Histiocyte | 4 |
Sinus, Mandibular, Ectasia | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 1|
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 4 |
Sinus, Ectasia | 2 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 3 1 4 |
Hyperplasia, Lymphoid | 1 2 |
Necrosis, Acute | |
__________________________________________________________________________|
Thymus | M + + M + + + + M M + + + M + + + M + + M M M + M|
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + + M + M + + + M M M + + + + + M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Necrotizing | 3 |
Parasite Metazoan | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | 2 |
Artery, Necrosis, Fibrinoid | 2 |
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchus, Granuloma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 3| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 1| 2| 2| 9| 0| 2| 8| 2| 2| 2| 2| 3| 3| 2| 8| 3| 3| 4| 3| 3| 2| 1| 0| 3| 3|
| 0| 9| 9| 2| 9| 9| 7| 9| 9| 7| 9| 0| 0| 1| 0| 0| 0| 1| 0| 0| 6| 2| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Atrophy | |
Hyperplasia, Nodular | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Metaplasia, Osseous | 2 |
Nephropathy, Chronic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 2| 3| 7| 2| 3| 3| |
| 1| 1| 1| 2| 3| 3| 2| 2| 2| 2| 2| 3| 0| 3| 3| 6| 0| 6| 6| 4| 6| 7| 1| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + + +| 45 |
Epithelium, Inclusion Body | | |
Intracytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 1.0|
Ulcer | 3 | 2 3.5|
Peyer's Patch, Infiltration Cellular,| | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + M + + + + +| 47 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytomegaly | 1 1 1 1 1 1 1 1 | 14 1.1|
Eosinophilic Focus | | 2 2.0|
Fatty Change | 1 | 2 1.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Necrosis, Coagulative | 3 1| 5 1.8|
Hepatocyte, Necrosis | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Inflammation, Necrotizing | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | | 2 3.0|
Duct, Ectasia | | 1 3.0|
Interlobular, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 | 1 4.0|
Bacterium | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + M + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + + + A + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + M + + + + + + + A + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 2| 3| 7| 2| 3| 3| |
| 1| 1| 1| 2| 3| 3| 2| 2| 2| 2| 2| 3| 0| 3| 3| 6| 0| 6| 6| 4| 6| 7| 1| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Pulmonary Artery, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | 1 | 1 1.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Valve, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 3 2.0|
Hyperplasia | 2 | 3 1.3|
Zona Reticularis, Vacuolization | | |
Cytoplasmic | 4 2 3 | 4 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + M M + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Nodular | 1 3 2 3 2 | 9 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Follicle, Hyperplasia, Nodular | 2 3 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 2 |
Abscess | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 3 3.7|
Thrombosis | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 2| 3| 7| 2| 3| 3| |
| 1| 1| 1| 2| 3| 3| 2| 2| 2| 2| 2| 3| 0| 3| 3| 6| 0| 6| 6| 4| 6| 7| 1| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Follicle, Cyst | X | 2 |
Periovarian Tissue, Cyst | X X X X X X | 8 |
Rete Ovarii, Cyst | | 3 |
__________________________________________________________________________|____________|
Oviduct | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Inflammation, Acute | | 2 2.5|
Inflammation, Granulomatous | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 4 1 3 2 1 1 2 2 3 2 3 4 2 2 3| 38 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Myelofibrosis | 2 3 1 1 1 2 1 2 | 13 1.5|
Femoral, Myelofibrosis | 1 2 1 1 1 1 1 2 | 13 1.3|
Sternal, Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + M + M + + + + + + + + + + + + + + + + + + + +| 48 |
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | | 1 4.0|
Sinus, Mandibular, Ectasia | 1 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 15 |
Hematopoietic Cell Proliferation | 1 | 4 1.3|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
Sinus, Ectasia | 2 1 2 1 2 | 7 1.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 4 1 | 9 2.0|
Hyperplasia, Lymphoid | | 2 1.5|
Necrosis, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M M + + + + M + M + + M M + + M + M M + +| 31 |
Amyloid Deposition | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + A + + + + + + M + M M + +| 34 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 28 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0|
Inflammation, Necrotizing | | 1 3.0|
Parasite Metazoan | X X X X X X X X X X X X X | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 2| 3| 7| 2| 3| 3| |
| 1| 1| 1| 2| 3| 3| 2| 2| 2| 2| 2| 3| 0| 3| 3| 6| 0| 6| 6| 4| 6| 7| 1| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + I + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic | | 1 2.0|
Artery, Necrosis, Fibrinoid | | 1 2.0|
Hypothalamus, Compression | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchus, Granuloma | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 6 |
Atrophy | 1 | 1 1.0|
Hyperplasia, Nodular | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Infarct | 2 | 1 2.0|
Metaplasia, Osseous | 1 | 2 1.5|
Nephropathy, Chronic | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 3| 2| 2| 2| 2| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0|
| 9| 7| 9| 9| 0| 9| 9| 9| 9| 0| 0| 9| 0| 0| 6| 0| 0| 0| 1| 1| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X X X X X X X X 2 X X |
Cytomegaly | 3 3 3 3 3 2 3 3 1 3 3 2 1 2 3 3 3 3 3 3 2 3 3 2|
Eosinophilic Focus | X 4 X 3 X 3 3 4 3 X |
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | 2 1 3 2 1 2 1 2 1 3 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 1 1 1 |
Hepatocyte, Necrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Sinusoid, Congestion | 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Inflammation, Necrotizing | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 4|
Necrosis | 3 |
Acinus, Atrophy | 4 |
Artery, Inflammation, Chronic | 2 |
Duct, Ectasia | 2 4 |
Interlobular, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Mucocele | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 3| 2| 2| 2| 2| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0|
| 9| 7| 9| 9| 0| 9| 9| 9| 9| 0| 0| 9| 0| 0| 6| 0| 0| 0| 1| 1| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Acute, | |
Multifocal | 1 2 |
Myocardium, Mineralization, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Zona Reticularis, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Hyperplasia, Nodular | 1 3 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + M + + + + + + + + + M + + + +|
Inflammation, Chronic Active | |
Mineralization | |
Follicle, Cyst | X X X X |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 3 1 2 2 2 1 1 3 1 2 3 1 2 1 1 2|
Endometrium, Endothelium, Metaplasia,| |
Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 3| 2| 2| 2| 2| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0|
| 9| 7| 9| 9| 0| 9| 9| 9| 9| 0| 0| 9| 0| 0| 6| 0| 0| 0| 1| 1| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 1 |
Femoral, Myelofibrosis | 1 2 1 1 |
Sternal, Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Abscess | 3 |
Mandibular, Bacterium | X |
Mandibular, Hyperplasia, Lymphoid | |
Renal, Infiltration Cellular, | |
Histiocyte | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 3|
Infiltration Cellular, Histiocyte | 2 |
Sinus, Ectasia | 2 4 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + M + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + + + + M + + M + + + M + + + + M M|
__________________________________________________________________________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Necrotizing | 2 |
Parasite Metazoan | X X X X X X X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | X|
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Alveolus, Inflammation, Acute | 1 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 1| 2| 2| 3| 2| 2| 2| 2| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0|
| 9| 7| 9| 9| 0| 9| 9| 9| 9| 0| 0| 9| 0| 0| 6| 0| 0| 0| 1| 1| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nerve, Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Mineralization | 2 |
Nephropathy, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 0| 6| 6| 3| 3| |
| 1| 1| 2| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 6| 0| 6| 0| 6| 4| 2| 1| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + M + + + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 2 |
Clear Cell Focus | X X X X X 3 X X X X| 22 2.5|
Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 49 2.8|
Eosinophilic Focus | 3 3 X 4 2 2 X 2| 18 3.0|
Fatty Change | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
Hematopoietic Cell Proliferation | 3 2 | 3 2.3|
Necrosis, Coagulative | 1 1 2 1 2 4 1 1| 18 1.7|
Thrombosis | X | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 | 9 1.0|
Hepatocyte, Necrosis | 1 1 1 1 1 1 1 1 1 1 | 23 1.0|
Sinusoid, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Inflammation, Chronic | 3 3 | 2 3.0|
Inflammation, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypoplasia | | 1 4.0|
Necrosis | 3 | 2 3.0|
Acinus, Atrophy | | 1 4.0|
Artery, Inflammation, Chronic | | 1 2.0|
Duct, Ectasia | 1 2| 4 2.3|
Interlobular, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 0| 6| 6| 3| 3| |
| 1| 1| 2| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 6| 0| 6| 0| 6| 4| 2| 1| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Abscess | | 1 4.0|
Mucocele | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Ulcer | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Inflammation, Acute, | | |
Multifocal | | 2 1.5|
Myocardium, Mineralization, | | |
Multifocal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 | 3 2.7|
Zona Reticularis, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia, Nodular | 1 1 1 | 7 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Hyperplasia, Nodular | 3 1 1 4 | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 0| 6| 6| 3| 3| |
| 1| 1| 2| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 6| 0| 6| 0| 6| 4| 2| 1| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mineralization | 1 | 1 1.0|
Follicle, Cyst | X X | 6 |
Periovarian Tissue, Cyst | X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 4 1 1 3 4 1 1 2 1 2 3 1 1 3| 32 1.9|
Endometrium, Endothelium, Metaplasia,| | |
Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Myelofibrosis | 2 1 2 1 | 5 1.4|
Femoral, Myelofibrosis | 1 2 1 1 1 | 9 1.2|
Sternal, Myelofibrosis | 2 1 2 1 1 1 1 1 1 1| 11 1.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Abscess | | 1 3.0|
Mandibular, Bacterium | | 1 |
Mandibular, Hyperplasia, Lymphoid | 4 | 1 4.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + +| 21 |
Hematopoietic Cell Proliferation | 1 | 5 1.4|
Hyperplasia, Lymphoid | 1 3 1 3 | 5 2.0|
Hyperplasia, Plasma Cell | | 2 2.5|
Infiltration Cellular, Histiocyte | | 1 2.0|
Sinus, Ectasia | 1 2 2| 6 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 4 | 5 2.0|
Hyperplasia, Lymphoid | 1 3 3 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + M M + + M + + + M + + + + + + + M + I M + + M| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M M M + + + + M + + M + M M M + M + M + +| 32 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 44 1.1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0|
Inflammation, Necrotizing | | 1 2.0|
Parasite Metazoan | X X X X X X X X X X X X X X X X X X X X X| 43 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 0| 6| 6| 3| 3| |
| 1| 1| 2| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 6| 0| 6| 0| 6| 4| 2| 1| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Compression | X | 2 |
Hypothalamus, Compression | X X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Alveolus, Inflammation, Acute | | 1 1.0|
Interstitium, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nerve, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 2| 2 2.0|
Nephropathy, Chronic | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 1| 7| 5|
DAY ON TEST | 2| 9| 2| 6| 2| 2| 9| 2| 2| 2| 3| 3| 3| 5| 3| 3| 5| 3| 2| 2| 3| 3| 9| 3| 7|
| 9| 4| 9| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| 0| 4| 0| 5| 4| 1| 1| 4| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + M + + + + + + + + + M + M + + + A + +|
Epithelium, Inclusion Body | |
Intracytoplasmic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + M + +|
Parasite Metazoan | X X |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X 1 X X X |
Clear Cell Focus | X 2 X X X |
Cytomegaly | 3 3 3 3 3 3 3 2 2 2 3 3 2 3 3 3 2 3 3 3 3 3 3 3 |
Eosinophilic Focus | 2 3 2 3 3 |
Fatty Change | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | 2 1 1 2 1 1 1 1|
Thrombosis | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 2 |
Hepatocyte, Necrosis | 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 |
Artery, Inflammation, Chronic | 3 |
Interlobular, Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 1| 7| 5|
DAY ON TEST | 2| 9| 2| 6| 2| 2| 9| 2| 2| 2| 3| 3| 3| 5| 3| 3| 5| 3| 2| 2| 3| 3| 9| 3| 7|
| 9| 4| 9| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| 0| 4| 0| 5| 4| 1| 1| 4| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Epithelium, Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Zona Reticularis, Vacuolization | |
Cytoplasmic | 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 3 1 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Follicle, Hyperplasia, Nodular | 1 2 2 2 1 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + M + + + + + + + + + + + + + +|
Thrombosis | X |
Follicle, Cyst | X X |
Periovarian Tissue, Cyst | X X X X X |
Rete Ovarii, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 1 3 2 2 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 1| 7| 5|
DAY ON TEST | 2| 9| 2| 6| 2| 2| 9| 2| 2| 2| 3| 3| 3| 5| 3| 3| 5| 3| 2| 2| 3| 3| 9| 3| 7|
| 9| 4| 9| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| 0| 4| 0| 5| 4| 1| 1| 4| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 1 |
Sternal, Myelofibrosis | 1 1 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + +|
Sinus, Mandibular, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 2 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 2 2 1 |
Inflammation, Granulomatous | |
Sinus, Ectasia | 3 1 2 2 2 2 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Granuloma | |
Hematopoietic Cell Proliferation | 2 3 1 1 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + M + M + + M + + M + M M M M M + + M M M + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + + + + + + + + + M + + + + M M + + M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Necrotizing | |
Parasite Metazoan | X X X X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Artery, Thrombosis | X |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 1| 7| 5|
DAY ON TEST | 2| 9| 2| 6| 2| 2| 9| 2| 2| 2| 3| 3| 3| 5| 3| 3| 5| 3| 2| 2| 3| 3| 9| 3| 7|
| 9| 4| 9| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| 0| 4| 0| 5| 4| 1| 1| 4| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Middle Ear, Abscess | |
Middle Ear, Bacterium | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Nephropathy, Chronic | 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| 3| 1| 6| 3| 2| 3| 3| 3| |
| 1| 1| 3| 2| 2| 2| 2| 2| 8| 2| 3| 2| 3| 3| 3| 1| 1| 6| 8| 3| 6| 4| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + A + + + + A + M A + + + +| 38 |
Epithelium, Inclusion Body | | |
Intracytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + +| 46 |
Parasite Metazoan | | 2 |
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + M A + + + + + + + +| 47 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + M + + + + +| 46 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + M + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A A + + A + + + + +| 47 |
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X X | 8 1.0|
Clear Cell Focus | X X X X X X X X| 13 2.0|
Cytomegaly | 3 3 3 2 3 3 2 3 3 2 2 3 3 3 3 3 3 3 3 3 3 3 2 2 3| 49 2.8|
Eosinophilic Focus | X 3 X 1 4 X X 2 2 2 3 | 16 2.5|
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Coagulative | 2 | 9 1.3|
Thrombosis | X | 1 |
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1| 9 1.1|
Hepatocyte, Necrosis | 1 1 1 1 1 1 1 1 1 | 15 1.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 2 1.5|
Artery, Inflammation, Chronic | 2 | 2 2.5|
Interlobular, Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| 3| 1| 6| 3| 2| 3| 3| 3| |
| 1| 1| 3| 2| 2| 2| 2| 2| 8| 2| 3| 2| 3| 3| 3| 1| 1| 6| 8| 3| 6| 4| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 1.0|
Epithelium, Metaplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Zona Reticularis, Vacuolization | | |
Cytoplasmic | 3 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + M + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + M + + + +| 47 |
Pars Distalis, Hyperplasia, Nodular | 2 3 2 3 | 8 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Follicle, Hyperplasia, Nodular | 4 1 1 | 11 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| 3| 1| 6| 3| 2| 3| 3| 3| |
| 1| 1| 3| 2| 2| 2| 2| 2| 8| 2| 3| 2| 3| 3| 3| 1| 1| 6| 8| 3| 6| 4| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Thrombosis | | 1 |
Follicle, Cyst | X X | 4 |
Periovarian Tissue, Cyst | X X X X| 9 |
Rete Ovarii, Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
Thrombosis | X | 1 |
Endometrium, Hyperplasia, Cystic | 2 1 2 1 3 3 1 1 1 1 1 2 3 3| 24 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Myelofibrosis | 1 2 1| 5 1.4|
Sternal, Myelofibrosis | 1 1 1 1 1 1 1 | 11 1.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sinus, Mandibular, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + +| 23 |
Hematopoietic Cell Proliferation | 2 2 1 1| 8 1.6|
Hyperplasia, Lymphoid | 2 1 | 3 2.0|
Infiltration Cellular, Histiocyte | 2| 4 1.8|
Inflammation, Granulomatous | 4 | 1 4.0|
Sinus, Ectasia | 3 4 2 1 2 2 3 2 | 15 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | | 1 2.0|
Granuloma | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 2 1 3 | 8 1.8|
Hyperplasia, Lymphoid | 1 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + M + + + + + + M M + + + M M M + +| 29 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + M + + + + + + M + M + M + M + + +| 37 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0|
Inflammation, Necrotizing | 3 | 1 3.0|
Parasite Metazoan | X X X X X X X X X X X X X X X X X X X| 38 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| 3| 1| 6| 3| 2| 3| 3| 3| |
| 1| 1| 3| 2| 2| 2| 2| 2| 8| 2| 3| 2| 3| 3| 3| 1| 1| 6| 8| 3| 6| 4| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypothalamus, Compression | X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Artery, Thrombosis | | 1 |
Interstitium, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Middle Ear, Abscess | 4 | 1 4.0|
Middle Ear, Bacterium | X | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
Nephropathy, Chronic | 2 1 | 6 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 4| 6| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 2| 2| 5| 6| 4| 9| 9| 2| 3| 3| 1| 0| 8| 7| 1| 8| 3| 3| 5| 3| 9| 1| 0| 8|
| 9| 9| 9| 6| 7| 5| 2| 2| 9| 0| 5| 7| 6| 4| 6| 7| 8| 0| 0| 5| 1| 7| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + + M + + M + + + + + + + + M|
Hemorrhage | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + A M + + + + + + M + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + A A + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X X |
Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Eosinophilic Focus | 2 3 |
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | 3 1 1 3 2 1 2 3 1 2 3 2 1 1|
Thrombosis | X X X X |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + M + + + + + + + + + +|
Hemorrhage | 3 |
Artery, Inflammation, Chronic | 1 3 |
Duct, Ectasia | |
Interlobular, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 4| 6| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 2| 2| 5| 6| 4| 9| 9| 2| 3| 3| 1| 0| 8| 7| 1| 8| 3| 3| 5| 3| 9| 1| 0| 8|
| 9| 9| 9| 6| 7| 5| 2| 2| 9| 0| 5| 7| 6| 4| 6| 7| 8| 0| 0| 5| 1| 7| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + + + M M + M M + + + + + + I + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + M M + + + + + + + +|
Pars Distalis, Hyperplasia, Nodular | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + M + +|
Mineralization | |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | |
Rete Ovarii, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 1 |
Sternal, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 2 |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 4 3 3 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 3 2 3 3 1 4 2 2 2 1 1 3 4 |
__________________________________________________________________________|
Thymus | + + + M + + M M M M + + + + M M M + + M + M M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M + M + + M M M + + + M + + + + M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 4| 6| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 2| 2| 5| 6| 4| 9| 9| 2| 3| 3| 1| 0| 8| 7| 1| 8| 3| 3| 5| 3| 9| 1| 0| 8|
| 9| 9| 9| 6| 7| 5| 2| 2| 9| 0| 5| 7| 6| 4| 6| 7| 8| 0| 0| 5| 1| 7| 7| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Mast Cell | |
Parasite Metazoan | X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Artery, Thrombosis | |
Lymphatic, Infiltration Cellular, | |
Polymorphonuclear | 3 |
Vein, Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia, Nodular | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy, Chronic | 2 1 |
Glomerulus, Inflammation, | |
Membranoproliferative | 1 |
Renal Tubule, Casts Protein | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 5| 4| 3| 3| 3| 5| 5| 0| 4| 0| 1| 3| 1| 2| 1| 2| 3| 3| 3| 3| 3| 1| |
| 5| 1| 1| 1| 6| 2| 6| 2| 4| 1| 3| 8| 9| 1| 2| 0| 5| 7| 7| 1| 3| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 45 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + A + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X X| 3 |
Clear Cell Focus | 2 3 | 4 2.5|
Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3| 50 3.0|
Eosinophilic Focus | 2 2 | 4 2.3|
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Necrosis, Coagulative | 2 2 2 1 1 2 3 2 3 1 3 1 2 3 3 2 2 | 31 2.0|
Thrombosis | X X X | 7 |
Bile Duct, Hyperplasia | 1 1 1 1 1 | 6 1.0|
Hepatocyte, Necrosis | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 3.0|
Artery, Inflammation, Chronic | 2 2 1 2 | 6 1.8|
Duct, Ectasia | 4 4 | 2 4.0|
Interlobular, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + + M + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 5| 4| 3| 3| 3| 5| 5| 0| 4| 0| 1| 3| 1| 2| 1| 2| 3| 3| 3| 3| 3| 1| |
| 5| 1| 1| 1| 6| 2| 6| 2| 4| 1| 3| 8| 9| 1| 2| 0| 5| 7| 7| 1| 3| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + M M + + + +| 44 |
Pars Distalis, Hyperplasia, Nodular | 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Hyperplasia, Nodular | 4 1 1 1 2 2 2 2 2| 15 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 2 | 1 2.0|
Follicle, Cyst | X | 2 |
Periovarian Tissue, Cyst | X X X X | 4 |
Rete Ovarii, Cyst | X X| 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Endometrium, Hyperplasia, Cystic | 1 2 1 1 1 1 3 | 11 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Myelofibrosis | | 1 1.0|
Sternal, Myelofibrosis | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + M + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 20 |
Hematopoietic Cell Proliferation | 3 1 2 | 7 2.0|
Hyperplasia, Lymphoid | 4 1 | 3 3.0|
Hyperplasia, Plasma Cell | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 5| 4| 3| 3| 3| 5| 5| 0| 4| 0| 1| 3| 1| 2| 1| 2| 3| 3| 3| 3| 3| 1| |
| 5| 1| 1| 1| 6| 2| 6| 2| 4| 1| 3| 8| 9| 1| 2| 0| 5| 7| 7| 1| 3| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sinus, Ectasia | 2 2 3 3 2 2 2 | 13 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 1 1 2 2 1 1 | 23 2.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + M M + M M + + M M M + + + + M + M| 27 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M + M + M M + M M + + M M M M M + M + + M| 26 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 43 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0|
Infiltration Cellular, Mast Cell | 2 | 1 2.0|
Parasite Metazoan | X X X X X X X X X X X X X X X X X X X X X X| 41 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Artery, Thrombosis | X X | 2 |
Lymphatic, Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Vein, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Hyperplasia, Nodular | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 5| 4| 3| 3| 3| 5| 5| 0| 4| 0| 1| 3| 1| 2| 1| 2| 3| 3| 3| 3| 3| 1| |
| 5| 1| 1| 1| 6| 2| 6| 2| 4| 1| 3| 8| 9| 1| 2| 0| 5| 7| 7| 1| 3| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 3 2 3 | 5 2.2|
Glomerulus, Inflammation, | | |
Membranoproliferative | 1 | 2 1.0|
Renal Tubule, Casts Protein | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 6| 5| 6| 5| 5| 4| 5| 5| 5| 6| 6| 6| 6| 4| 6| 6| 5|
DAY ON TEST | 6| 2| 0| 6| 4| 8| 1| 3| 7| 3| 2| 1| 9| 9| 9| 0| 7| 3| 3| 6| 7| 4| 3| 5| 7|
| 5| 2| 6| 1| 1| 3| 7| 6| 8| 2| 0| 5| 2| 1| 5| 8| 6| 3| 4| 0| 1| 0| 5| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + M + M + M A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X X X X X X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A M + + + + + + M + + + M + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + A + + + + + + A + + M + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Cyst | X |
Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Eosinophilic Focus | |
Fatty Change | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | 3 2 3 3 1 1 2 3 2 1 2 1 1 2 1 3 2 |
Thrombosis | X X X X X |
Bile Duct, Cyst | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 1 1 2 3 1 2 1 2 3 1 3 1 1 2 2 2|
Hepatocyte, Necrosis | 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + M + + + + + + A + + + + + + + + + + + + + +|
Infarct | 4 |
Artery, Inflammation, Chronic | 3 4 2 1 3 4 3 |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + M + + + + + M +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Heart | + + M + + + + + + + + + + + + + + + + + + + + +|
Atrium, Dilatation | 4 |
Coronary Artery, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 6| 5| 6| 5| 5| 4| 5| 5| 5| 6| 6| 6| 6| 4| 6| 6| 5|
DAY ON TEST | 6| 2| 0| 6| 4| 8| 1| 3| 7| 3| 2| 1| 9| 9| 9| 0| 7| 3| 3| 6| 7| 4| 3| 5| 7|
| 5| 2| 6| 1| 1| 3| 7| 6| 8| 2| 0| 5| 2| 1| 5| 8| 6| 3| 4| 0| 1| 0| 5| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Infarct | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + M M + + + + + + A + + + + + + + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + M + M + M M + +|
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + M + + + + + +|
Follicle, Hyperplasia, Nodular | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + M + + + + + + + + + + + +|
Mineralization | |
Follicle, Cyst | |
Periovarian Tissue, Cyst | X |
Rete Ovarii, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + M + + M + + + +|
Mandibular, Hyperplasia, Lymphoid | 2 |
Pancreatic, Sinus, Ectasia | |
Sinus, Mandibular, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Histiocyte | 2 |
Sinus, Ectasia | 3 4 2 |
__________________________________________________________________________|
Spleen | + + M + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 1 3 2 3 2 1 3 3 2 2 2 3 2 3 3 2|
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | M M M M M M + M M M M + M M + M + + I + + M + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 6| 5| 6| 5| 5| 4| 5| 5| 5| 6| 6| 6| 6| 4| 6| 6| 5|
DAY ON TEST | 6| 2| 0| 6| 4| 8| 1| 3| 7| 3| 2| 1| 9| 9| 9| 0| 7| 3| 3| 6| 7| 4| 3| 5| 7|
| 5| 2| 6| 1| 1| 3| 7| 6| 8| 2| 0| 5| 2| 1| 5| 8| 6| 3| 4| 0| 1| 0| 5| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + + + M + + + + M + M + M M + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Parasite Metazoan | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + M + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia, Nodular | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 2 |
Nephropathy, Chronic | 2 2 2 1 3 2 3 2|
Glomerulus, Inflammation, | |
Membranoproliferative | 1 |
Glomerulus, Nephropathy, Chronic | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 4| 5| 5| 3| 4| 5| 5| 5| 6| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
DAY ON TEST | 7| 1| 8| 7| 8| 2| 3| 5| 7| 1| 1| 4| 8| 9| 8| 8| 1| 8| 3| 9| 3| 0| 0| 0| 3| |
| 3| 9| 4| 5| 4| 9| 3| 9| 0| 5| 9| 4| 3| 9| 9| 5| 3| 0| 3| 5| 0| 5| 5| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M M + + + + + + M + + + + + + + + + + + + + + M +| 44 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + M + + + + + + M + + + + + + + M +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + M + + + + + + + + + + + + + + + M + + + +| 45 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M M + + M + + + + + + + + + + + M + + + M + + + +| 44 |
Parasite Metazoan | X X X X X X X X X | 22 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + M + + + + + + + + + + + + M + + + + + + + +| 45 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + M A M + + + + + A +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + A + M + + + + + + A + + + + A + + + M + + + +| 39 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + A + + + + A + + + M + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Clear Cell Focus | | 1 |
Cyst | X | 2 |
Cytomegaly | 3 3 3 3 3 3 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 48 3.0|
Eosinophilic Focus | 2 3 X 4| 4 3.0|
Fatty Change | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.1|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Coagulative | 2 1 1 2 1 1 3 2 1 1 1 2 1 1 1 1 1 | 34 1.6|
Thrombosis | X | 6 |
Bile Duct, Cyst | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 1 2 2 1 2 2 2 2 3 1 1 1 1| 40 1.8|
Hepatocyte, Necrosis | 1 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + A + + + + + + A M M + + + M + + +| 41 |
Infarct | | 1 4.0|
Artery, Inflammation, Chronic | 4 | 8 3.0|
__________________________________________________________________________|____________|
Salivary Glands | M M + + + M + + + + + + + M + + + M + + + + + M +| 40 |
__________________________________________________________________________|____________|
Stomach | + + + + M + + + + + + + + + + M + M + + + + + M +| 45 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + + + + + + M + M + + + + + M +| 45 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + M + + + + + + + + + + M + M + + + + + M +| 44 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 4| 5| 5| 3| 4| 5| 5| 5| 6| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
DAY ON TEST | 7| 1| 8| 7| 8| 2| 3| 5| 7| 1| 1| 4| 8| 9| 8| 8| 1| 8| 3| 9| 3| 0| 0| 0| 3| |
| 3| 9| 4| 5| 4| 9| 3| 9| 0| 5| 9| 4| 3| 9| 9| 5| 3| 0| 3| 5| 0| 5| 5| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Aorta, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Heart | M + + + M + + + + + + + + + + + + + + + + + + M +| 45 |
Atrium, Dilatation | | 1 4.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + + + + + + M + + + + M + + +| 44 |
Subcapsular, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + M + + + + M + + +| 43 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + M + + + + M + + +| 43 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + A + + + + + + A M M + + + M + + +| 39 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + M + + M + + + + M + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | M M + + + M + + M + + + + + + M + M + + + I + M +| 36 |
__________________________________________________________________________|____________|
Thyroid Gland | M M + + + M + + + + + + + + + + + + + + + + + M +| 43 |
Follicle, Hyperplasia, Nodular | 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + M + + + + + + + + + + + M + + + + + + + +| 45 |
Mineralization | 3 | 1 3.0|
Follicle, Cyst | X | 1 |
Periovarian Tissue, Cyst | | 1 |
Rete Ovarii, Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Pigmentation | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + M + + + + + + + + + + + M + + + + + M +| 42 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Sinus, Ectasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 4| 5| 5| 3| 4| 5| 5| 5| 6| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
DAY ON TEST | 7| 1| 8| 7| 8| 2| 3| 5| 7| 1| 1| 4| 8| 9| 8| 8| 1| 8| 3| 9| 3| 0| 0| 0| 3| |
| 3| 9| 4| 5| 4| 9| 3| 9| 0| 5| 9| 4| 3| 9| 9| 5| 3| 0| 3| 5| 0| 5| 5| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sinus, Mandibular, Ectasia | 1| 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + +| 7 |
Hematopoietic Cell Proliferation | 2| 2 1.5|
Infiltration Cellular, Histiocyte | | 1 2.0|
Sinus, Ectasia | 3 1 | 5 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + M + + + + + + + + + + M + M + + + M + + +| 44 |
Hematopoietic Cell Proliferation | 3 1 1 2 2 2 2 1 3 2 2 1 1 2 2 1 2| 37 2.1|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + M M M M + + M + + + + M M + M I M + + M M M +| 20 |
Ectopic Parathyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M M M + M M M M M M + + + + M +| 23 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
Parasite Metazoan | X X X X X X X X X X X X X X X X X| 33 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | M M + + + M + + + + + + + + + + + + + + + + + M +| 44 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | M + + + + + + + + + + + + + + + + + + + + + + M +| 46 |
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Interstitium, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | M M + + + M + + + + + + + + + + + + + + + + + M +| 44 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia, Nodular | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + M + + + + + + + + + + + M + + + + M + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 4| 5| 5| 3| 4| 5| 5| 5| 6| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| |
DAY ON TEST | 7| 1| 8| 7| 8| 2| 3| 5| 7| 1| 1| 4| 8| 9| 8| 8| 1| 8| 3| 9| 3| 0| 0| 0| 3| |
| 3| 9| 4| 5| 4| 9| 3| 9| 0| 5| 9| 4| 3| 9| 9| 5| 3| 0| 3| 5| 0| 5| 5| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Metaplasia, Osseous | | 1 2.0|
Nephropathy, Chronic | 2 1 2 3 1 3 1 2 | 16 2.0|
Glomerulus, Inflammation, | | |
Membranoproliferative | | 1 1.0|
Glomerulus, Nephropathy, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + A + + + + M + + + + + + A +| 45 |
Parasite Metazoan | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 3| 5| 4| 2| 5| 4| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|
DAY ON TEST | 5| 8| 9| 8| 8| 6| 7| 4| 1| 1| 0| 9| 3| 4| 3| 1| 1| 0| 1| 2| 1| 3| 0| 0| 0|
| 4| 9| 5| 0| 4| 9| 0| 2| 2| 5| 1| 1| 3| 5| 3| 1| 9| 6| 5| 0| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + M + M + + + M A + A + + + M + + M M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + + + + + +|
Parasite Metazoan | X X X X X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + M + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + A + M +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + I +|
Clear Cell Focus | X 1 X |
Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Eosinophilic Focus | 3 X 3 3 3 3 |
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | 2 2 2 1 1 1 2 1 |
Thrombosis | X X |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 |
Hepatocyte, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Artery, Inflammation, Chronic | 1 1 |
Interlobular, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + M +|
Subcapsular, Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + M +|
Hematopoietic Cell Proliferation | 2 1 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 3| 5| 4| 2| 5| 4| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|
DAY ON TEST | 5| 8| 9| 8| 8| 6| 7| 4| 1| 1| 0| 9| 3| 4| 3| 1| 1| 0| 1| 2| 1| 3| 0| 0| 0|
| 4| 9| 5| 0| 4| 9| 0| 2| 2| 5| 1| 1| 3| 5| 3| 1| 9| 6| 5| 0| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + M + + + + + M + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + M + + + +|
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + M + + + + + + M +|
Mandibular, Hematopoietic Cell | |
Proliferation | 2 |
Mandibular, Hyperplasia, Lymphoid | 2 |
Sinus, Mandibular, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 2 2 |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 3 1 2 1 2 2 3 2 1 2 3 2 |
__________________________________________________________________________|
Thymus | M M + + + + + + + M + + M + + M + + + + M + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + + + + + M + + + M + + + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Parasite Metazoan | X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 3| 5| 4| 2| 5| 4| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|
DAY ON TEST | 5| 8| 9| 8| 8| 6| 7| 4| 1| 1| 0| 9| 3| 4| 3| 1| 1| 0| 1| 2| 1| 3| 0| 0| 0|
| 4| 9| 5| 0| 4| 9| 0| 2| 2| 5| 1| 1| 3| 5| 3| 1| 9| 6| 5| 0| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic | 1 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 1 1 2 2 2 2 2 3 1 2 |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 5| 5| 6| 3| 3| 5| 4| 5| 5| 4| 3| 3| 3| 5| 4| 5| 5| 6| 5| 5| 4| |
DAY ON TEST | 1| 9| 3| 2| 1| 1| 0| 8| 8| 3| 7| 7| 5| 9| 4| 5| 6| 1| 6| 1| 0| 1| 5| 3| 6| |
| 9| 2| 3| 0| 9| 2| 6| 9| 9| 8| 7| 1| 7| 8| 7| 0| 4| 5| 3| 2| 1| 9| 4| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + M + M + + M + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Gallbladder | M + + + M M M M + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Intestine Large | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + M + + + M + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M + + + + M + + + M + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | X X X X X X X X | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + M + + + M + M + + + + + + + A + + + + +| 41 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + + + + M + A + + + + + + + A + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Clear Cell Focus | | 3 1.0|
Cytomegaly | 3 3 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 47 3.0|
Eosinophilic Focus | 3 3 | 8 3.0|
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
Hematopoietic Cell Proliferation | 2 2 | 2 2.0|
Necrosis, Coagulative | 2 3 2 3 3 4 1 1 1 1 2 1| 20 1.8|
Thrombosis | X X X X | 6 |
Bile Duct, Hyperplasia | 2 1 1 1 1 2 1 1 2 3 2 1 1 1 1 1 2 1 2 1 | 37 1.3|
Hepatocyte, Necrosis | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Pancreas | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | 2 | 1 2.0|
Artery, Inflammation, Chronic | 3 2 | 4 1.8|
Interlobular, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Stomach | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | M + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
Acanthosis | | 1 3.0|
Hyperkeratosis | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | M + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | M + M + M + + M + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 5| 5| 6| 3| 3| 5| 4| 5| 5| 4| 3| 3| 3| 5| 4| 5| 5| 6| 5| 5| 4| |
DAY ON TEST | 1| 9| 3| 2| 1| 1| 0| 8| 8| 3| 7| 7| 5| 9| 4| 5| 6| 1| 6| 1| 0| 1| 5| 3| 6| |
| 9| 2| 3| 0| 9| 2| 6| 9| 9| 8| 7| 1| 7| 8| 7| 0| 4| 5| 3| 2| 1| 9| 4| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Subcapsular, Hyperplasia | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | M + M + + M + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M + + M + + + + + + + + + + + + + M + +| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | M + M + M + + M M + + + + + + M + + + M + + + + +| 38 |
__________________________________________________________________________|____________|
Thyroid Gland | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 |
Follicle, Hyperplasia, Nodular | 1 1 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + M + + + + + + + + + + + + + + + M + + + + + +| 46 |
Periovarian Tissue, Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Endometrium, Hyperplasia, Cystic | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | M M M + M + + M + + + + + + + + + + + + + + + + +| 41 |
Mandibular, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Sinus, Mandibular, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 10 |
Hematopoietic Cell Proliferation | 3 2 2 | 8 2.1|
Sinus, Ectasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | 3 3 1 3 2 2 2 2 2 2 1 3 2 1| 29 2.1|
__________________________________________________________________________|____________|
Thymus | M M M + M + + M + + + + + + + M + + + + M M M M +| 32 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + + + + M M M M M + M M + M M M + + M M M M| 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 6| 5| 5| 6| 3| 3| 5| 4| 5| 5| 4| 3| 3| 3| 5| 4| 5| 5| 6| 5| 5| 4| |
DAY ON TEST | 1| 9| 3| 2| 1| 1| 0| 8| 8| 3| 7| 7| 5| 9| 4| 5| 6| 1| 6| 1| 0| 1| 5| 3| 6| |
| 9| 2| 3| 0| 9| 2| 6| 9| 9| 8| 7| 1| 7| 8| 7| 0| 4| 5| 3| 2| 1| 9| 4| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + M| 47 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0|
Parasite Metazoan | X X X X X X X X X X X X X X X X X | 31 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 |
Inflammation, Chronic | | 1 1.0|
Interstitium, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | M + + + M + + M + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Trachea | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 2 2 1 2 1 2 3 1 3 2 2 1 2 1 1 2 2| 29 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0| 3| 0|
| 7| 5| 7| 7| 7| 7| 7| 8| 8| 7| 8| 1| 8| 8| 9| 9| 9| 9| 9| 2| 0| 1| 5| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + A + + + + + + + + M + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | 2 |
Eosinophilic Focus | 2 |
Fatty Change | 3 2 |
Granuloma | 1 |
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Artery, Inflammation, Chronic | 3 |
Interlobular, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 |
Hyperkeratosis | 2 1 |
Inflammation, Necrotizing | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0| 3| 0|
| 7| 5| 7| 7| 7| 7| 7| 8| 8| 7| 8| 1| 8| 8| 9| 9| 9| 9| 9| 2| 0| 1| 5| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | |
Epicardium, Inflammation, Chronic | 1 1 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + M + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + M + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infarct | |
Zona Glomerulosa, Cytoplasmic | |
Alteration | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + M + M + + + + + + + + + M M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | 3 4 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Necrotizing | |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tunic, Inflammation, Necrotizing | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Sinus, Ectasia | |
Mandibular, Abscess | |
Mandibular, Bacterium | |
Mediastinal, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0| 3| 0|
| 7| 5| 7| 7| 7| 7| 7| 8| 8| 7| 8| 1| 8| 8| 9| 9| 9| 9| 9| 2| 0| 1| 5| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | |
Mediastinal, Hyperplasia, Plasma Cell| |
Sinus, Mandibular, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 2 2 2 2 1 2 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
Inflammation, Granulomatous | 2 |
Sinus, Ectasia | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 2 3 3|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Thymus | + M + M + + M M M + I + M + + + M M + M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Parasite Metazoan | X X X X X X X X X X X|
Subcutaneous Tissue, Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Artery, Thrombosis | X |
Bronchus, Foreign Body | |
Interstitium, Inflammation, Chronic | 1 |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 6| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0| 3| 0|
| 7| 5| 7| 7| 7| 7| 7| 8| 8| 7| 8| 1| 8| 8| 9| 9| 9| 9| 9| 2| 0| 1| 5| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | + +|
Inflammation, Necrotizing | 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy, Chronic | 1 1 2 2 1 |
Artery, Inflammation, Subacute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| |
DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 0| 9| 3| 3| 3| 3| 1| 4| 3| 4| 3| 5| |
| 0| 4| 8| 0| 0| 0| 1| 3| 1| 1| 1| 8| 1| 4| 1| 4| 4| 4| 4| 4| 5| 4| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + M + A + M + M + + A + + + + M + + A M +| 38 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + M + +| 47 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + M + M + + + + + + + + + +| 47 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + M + + + + + + + A + +| 47 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 2 | 2 2.5|
Cyst | | 1 2.0|
Eosinophilic Focus | 2 2 | 3 2.0|
Fatty Change | | 2 2.5|
Granuloma | | 1 1.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 5 |
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Necrotizing | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 | 1 4.0|
Artery, Inflammation, Chronic | | 1 3.0|
Interlobular, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Acanthosis | | 2 1.5|
Hyperkeratosis | | 2 1.5|
Inflammation, Necrotizing | | 1 2.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| |
DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 0| 9| 3| 3| 3| 3| 1| 4| 3| 4| 3| 5| |
| 0| 4| 8| 0| 0| 0| 1| 3| 1| 1| 1| 8| 1| 4| 1| 4| 4| 4| 4| 4| 5| 4| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Ectopic Tissue | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | 3 2 | 2 2.5|
Epicardium, Inflammation, Chronic | | 2 1.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +| 39 |
Subcapsular, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| 39 |
Hyperplasia | | 1 2.0|
Infarct | 3| 1 3.0|
Zona Glomerulosa, Cytoplasmic | | |
Alteration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +| 38 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + + + + + + + + + + + + I + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 3 |
Abscess | | 2 3.5|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Serosa, Inflammation, Necrotizing | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| |
DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 0| 9| 3| 3| 3| 3| 1| 4| 3| 4| 3| 5| |
| 0| 4| 8| 0| 0| 0| 1| 3| 1| 1| 1| 8| 1| 4| 1| 4| 4| 4| 4| 4| 5| 4| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tunic, Inflammation, Necrotizing | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + I + M + +| 48 |
Deep Cervical, Sinus, Ectasia | 3 | 1 3.0|
Mandibular, Abscess | 3 | 1 3.0|
Mandibular, Bacterium | X | 1 |
Mediastinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Sinus, Mandibular, Ectasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| 32 |
Hematopoietic Cell Proliferation | 3 2 3 2 3| 13 2.3|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
Sinus, Ectasia | 3 4 1 2 2 4 4 | 9 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 2 3 1 3 3 | 10 2.4|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + M + + M M M M M + I + + M + + + M +| 29 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1| 24 1.0|
Parasite Metazoan | X X X X X X X X X X X X| 23 |
Subcutaneous Tissue, Fat, Necrosis | 3 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Tarsal, Hyperostosis | X 2 | 5 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 5| 2| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| |
DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 0| 9| 3| 3| 3| 3| 1| 4| 3| 4| 3| 5| |
| 0| 4| 8| 0| 0| 0| 1| 3| 1| 1| 1| 8| 1| 4| 1| 4| 4| 4| 4| 4| 5| 4| 1| 4| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 2 2 2 | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Artery, Thrombosis | | 1 |
Bronchus, Foreign Body | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | 1 | 2 1.0|
Mediastinum, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Inflammation, Necrotizing | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 | 1 1.0|
Nephropathy, Chronic | 1 1 2 2 | 9 1.4|
Artery, Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2| 1 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 2| 9| 2| 6| 2| 7| 2| 2| 2| 1| 8| 2| 5| 2| 2| 5| 2| 2| 2| 1|
| 7| 7| 0| 7| 7| 7| 5| 7| 5| 8| 8| 8| 8| 8| 7| 5| 8| 5| 8| 9| 2| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + M A|
Epithelium, Hyperplasia | |
Epithelium, Inclusion Body | |
Intracytoplasmic | |
Lumen, Crystals | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + + + + A + + + + + A + + A + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Basophilic Focus | X X X X |
Clear Cell Focus | X 2 X X X X |
Cyst | X |
Cytologic Alterations | 2 1 2 2 2 3 2 1 2 2 |
Cytomegaly | 2 1 2 2 2 1 1 1 2 2 2 1 2 1 1 2 1 |
Eosinophilic Focus | 2 4 2 1 3 3 2 X 4 4 2|
Fatty Change | 1 |
Hematopoietic Cell Proliferation | 1 |
Necrosis, Coagulative | 2 2 2 3|
Thrombosis | X X X|
Hepatocyte, Necrosis | 1 1 1 |
__________________________________________________________________________|
Mesentery | + +|
Inflammation, Chronic | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interlobular, Inflammation, Chronic | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 2| 9| 2| 6| 2| 7| 2| 2| 2| 1| 8| 2| 5| 2| 2| 5| 2| 2| 2| 1|
| 7| 7| 0| 7| 7| 7| 5| 7| 5| 8| 8| 8| 8| 8| 7| 5| 8| 5| 8| 9| 2| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + + |
Gingiva, Inflammation, Chronic Active| 4 2 |
Pulp, Inflammation, Chronic Active | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + M + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 1 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hyperplasia | 1 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + M M + M + + + + + + + + M + + + + M + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Preputial Gland | + |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 2| 9| 2| 6| 2| 7| 2| 2| 2| 1| 8| 2| 5| 2| 2| 5| 2| 2| 2| 1|
| 7| 7| 0| 7| 7| 7| 5| 7| 5| 8| 8| 8| 8| 8| 7| 5| 8| 5| 8| 9| 2| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Mandibular, Abscess | 4 |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 2 3 1 3 2|
Infiltration Cellular, Histiocyte | 3 4 |
Inflammation, Granulomatous | |
Sinus, Ectasia | 3 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 2 3 2 2|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M M M M + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic | |
Inflammation, Necrotizing | 1 4 |
Parasite Metazoan | X X X X X X X X X X X X X X X X X X X X |
Ulcer | 2 |
Dermis, Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X 2|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 |
Bacterium | X |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 2| 9| 2| 6| 2| 7| 2| 2| 2| 1| 8| 2| 5| 2| 2| 5| 2| 2| 2| 1|
| 7| 7| 0| 7| 7| 7| 5| 7| 5| 8| 8| 8| 8| 8| 7| 5| 8| 5| 8| 9| 2| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Anterior Chamber, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X 2 |
Hydronephrosis | |
Infarct | 1 |
Nephropathy, Chronic | 1 3 1 2 |
Glomerulus, Amyloid Deposition | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 1| 2| 8| 0| 3| 3| |
| 9| 0| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 4| 4| 6| 4| 4| 4| 2| 1| 4| 1| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + + + + + M + + + + A + + A + +| 43 |
Epithelium, Hyperplasia | 4 | 1 4.0|
Epithelium, Inclusion Body | | |
Intracytoplasmic | 3 4 | 2 3.5|
Lumen, Crystals | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + M + +| 47 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 45 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 1 2.0|
Basophilic Focus | 3 4 | 6 3.5|
Clear Cell Focus | 2 X X 2 2 X X| 13 2.0|
Cyst | | 1 |
Cytologic Alterations | 1 2 1 2 2 1 2 2 2 2 3 | 21 1.9|
Cytomegaly | 1 2 1 2 3 1 2 2 1 3 1 2 2 4 1 2 2 1 1| 36 1.7|
Eosinophilic Focus | 3 X 1 3 3 X 4 4 3| 20 2.8|
Fatty Change | 1 | 2 1.0|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Necrosis, Coagulative | 1 1 2 2 3 | 9 2.0|
Thrombosis | X X X | 6 |
Hepatocyte, Necrosis | | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interlobular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 1| 2| 8| 0| 3| 3| |
| 9| 0| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 4| 4| 6| 4| 4| 4| 2| 1| 4| 1| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 4 |
Gingiva, Inflammation, Chronic Active| | 2 3.0|
Pulp, Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 1.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 1 3.0|
Hyperplasia | 1 | 3 1.3|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 1| 2| 8| 0| 3| 3| |
| 9| 0| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 4| 4| 6| 4| 4| 4| 2| 1| 4| 1| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Seminiferous Tubule, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deep Cervical, Hyperplasia, Plasma | | |
Cell | 2 | 1 2.0|
Mandibular, Abscess | | 1 4.0|
Mandibular, Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Mandibular, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| 34 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 1 1 1 2 | 12 1.8|
Infiltration Cellular, Histiocyte | 4 4 | 4 3.8|
Inflammation, Granulomatous | 3 | 1 3.0|
Sinus, Ectasia | 3 3 3 3 3 3 3 3| 18 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 2 4 2 | 9 2.1|
Hyperplasia, Lymphoid | 3 1 | 2 2.0|
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + M + M M + + + + + + M + +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 4.0|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Necrotizing | | 2 2.5|
Parasite Metazoan | X X X X X X X X X X X X X X X| 35 |
Ulcer | | 1 2.0|
Dermis, Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 1| 2| 8| 0| 3| 3| |
| 9| 0| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 4| 4| 6| 4| 4| 4| 2| 1| 4| 1| 7| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | 2 X X | 5 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 1.0|
Bacterium | | 1 |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Interstitium, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Cyst | 2 2 1 2 | 6 1.8|
Hydronephrosis | 4 | 1 4.0|
Infarct | | 1 1.0|
Nephropathy, Chronic | 2 1 1 2 | 8 1.6|
Glomerulus, Amyloid Deposition | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 7| 0| 2| 2| 2| 2| 3|
| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 8| 9| 5| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + A M + + + + + +|
Epithelium, Inclusion Body | |
Intracytoplasmic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A A + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + M + + + A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Abscess | 3 |
Bacterium | X |
Basophilic Focus | |
Clear Cell Focus | X X 1 X |
Cytomegaly | 2 2 2 1 1 2 1 1 2 2 1 1 2 2 1 2 1 2 1 1 1 1 1|
Eosinophilic Focus | 2 2 3 3 |
Fatty Change | 1|
Necrosis, Coagulative | 1 1 2 2 |
Thrombosis | X |
Bile Duct, Dilatation | |
Hepatocyte, Necrosis | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Fibrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A A + + + + + +|
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + + + |
Gingiva, Inflammation, Chronic Active| 3 2 |
Pulp, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 7| 0| 2| 2| 2| 2| 3|
| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 8| 9| 5| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 1 2 1 2 2 2 |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 2 2 |
Artery, Thrombosis | X |
Sinus, Ectasia | 1 2 2 4 2 3 2 2 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 4|
__________________________________________________________________________|
Thymus | + + + + + + + M M + + + + + + M + M M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
Parasite Metazoan | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 7| 0| 2| 2| 2| 2| 3|
| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 8| 9| 5| 9| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coccygeal, Fracture Healed | |
Femur, Osteopetrosis | |
Tarsal, Hyperostosis | X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Synechia | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2|
Infiltration Cellular, Lymphocyte | 3 |
Nephropathy, Chronic | 1 1 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | |
| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 7| 1| 0| 4| 4| 4| 4| 4| 4| 4| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
3 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
1-1 | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + | 45 |
Epithelium, Inclusion Body | | |
Intracytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + A + + + + + + + + + | 44 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + | 46 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + | 44 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + | 47 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Abscess | | 1 3.0|
Bacterium | | 1 |
Basophilic Focus | X | 1 |
Clear Cell Focus | X 3 X X X X X X X X X | 15 2.0|
Cytomegaly | 2 3 2 1 2 3 2 2 2 1 2 2 1 1 1 1 1 1 1 2 1 | 44 1.5|
Eosinophilic Focus | 3 3 4 2 | 8 2.8|
Fatty Change | 1 1 1 | 4 1.0|
Necrosis, Coagulative | 1 | 5 1.4|
Thrombosis | | 1 |
Bile Duct, Dilatation | 2 | 1 2.0|
Hepatocyte, Necrosis | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Duct, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Mucosa, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 4 |
Gingiva, Inflammation, Chronic Active| | 2 2.5|
Pulp, Inflammation, Chronic Active | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | |
| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 7| 1| 0| 4| 4| 4| 4| 4| 4| 4| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
3 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
1-1 | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 1 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + M | 46 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + A + + M + + + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + M + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Seminiferous Tubule, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + A + + + + + + + + + | 48 |
Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 34 |
Hematopoietic Cell Proliferation | 3 1 1 2 1 1 1 1 | 14 1.5|
Hyperplasia, Lymphoid | 4 2 2 2 3 3 | 8 2.5|
Infiltration Cellular, Histiocyte | 2 3 3 1 | 6 2.2|
Artery, Thrombosis | | 1 |
Sinus, Ectasia | 1 2 1 2 1 1 | 16 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + | 47 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 1 3 3 2 | 7 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | |
| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 7| 1| 0| 4| 4| 4| 4| 4| 4| 4| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
3 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
1-1 | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + M M + + + + + + + + M | 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 2 |
Duct, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Acanthosis | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 | 32 1.1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0|
Parasite Metazoan | X X X X X X X X X X X X X | 29 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Coccygeal, Fracture Healed | X | 1 |
Femur, Osteopetrosis | 2 | 1 2.0|
Tarsal, Hyperostosis | X X X X X X | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Bacterium | X | 1 |
Inflammation, Acute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Synechia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cyst | 2 | 3 2.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Nephropathy, Chronic | 1 1 | 8 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | |
| 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 7| 1| 0| 4| 4| 4| 4| 4| 4| 4| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
3 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
1-1 | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 0| 6| 2| 2| 2| 2| 1| 2| 2|
| 7| 7| 7| 0| 7| 3| 7| 0| 7| 8| 8| 8| 4| 8| 8| 8| 4| 1| 8| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + M + + + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
Ulcer | 2 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + A + + + + + + + +|
Parasite Metazoan | |
Ulcer | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Hyperplasia, Lymphoid | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X X X 2 X 2 |
Cyst | X |
Cytomegaly | 3 3 3 2 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Eosinophilic Focus | 3 X 4 2 3 3 3 3 2 3 3 |
Fatty Change | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis, Coagulative | 3 2 1 1 2 1 2 1|
Thrombosis | X X |
Hepatocyte, Necrosis | 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + |
Pulp, Inflammation, Chronic Active | 3 3 |
Pulp, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 1 |
Myocardium, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 0| 6| 2| 2| 2| 2| 1| 2| 2|
| 7| 7| 7| 0| 7| 3| 7| 0| 7| 8| 8| 8| 4| 8| 8| 8| 4| 1| 8| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Mineralization, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
Abscess | 3 |
__________________________________________________________________________|
Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + + + + + +|
Mandibular, Abscess | |
Mandibular, Bacterium | |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | 3 |
Mandibular, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 1 1 2 2 1 1 1 |
Hyperplasia, Lymphoid | 4 4 4 1|
Infiltration Cellular, Histiocyte | 2 2 2 2 2 |
Sinus, Ectasia | 2 4 3 1 3 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 0| 6| 2| 2| 2| 2| 1| 2| 2|
| 7| 7| 7| 0| 7| 3| 7| 0| 7| 8| 8| 8| 4| 8| 8| 8| 4| 1| 8| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 1 1 2 2 |
Hyperplasia, Lymphoid | 2 4 |
__________________________________________________________________________|
Thymus | M + + M + + + + M + + + + + + + M + M + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Parasite Metazoan | X X X X X X X X X X X X X X X X X X|
Sebaceous Gland, Ectasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Artery, Thrombosis | X |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia, Nodular | 1 |
Duct, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cyst | 2 |
Inflammation, Acute | |
Nephropathy, Chronic | 2 1 1 3 3 2 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 8| 3| 0| 0| 3| 6| 3| 3| 3| 2| 3| 3| 3| 6| 0| 3| 3| 3| 3| |
| 9| 7| 0| 0| 0| 0| 7| 0| 2| 5| 0| 7| 0| 1| 1| 3| 4| 4| 4| 0| 6| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + M + + + + + M + + + + + + M M + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 1 |
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X| 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + A + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X X | 2 |
Ulcer | 4 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + + + A + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | 3 X X| 3 3.0|
Clear Cell Focus | 3 | 8 2.3|
Cyst | | 1 |
Cytomegaly | 3 3 3 3 3 3 3 3 3 2 3 3 3 3 2 3 3 3 3 3 3 3 3 3| 49 2.9|
Eosinophilic Focus | 3 3 3 X 3 | 16 2.9|
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Necrosis, Coagulative | 2 1 2 2 2 3 1 2 2| 17 1.8|
Thrombosis | X | 3 |
Hepatocyte, Necrosis | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Artery, Inflammation, Chronic | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Pulp, Inflammation, Chronic Active | | 2 3.0|
Pulp, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 8| 3| 0| 0| 3| 6| 3| 3| 3| 2| 3| 3| 3| 6| 0| 3| 3| 3| 3| |
| 9| 7| 0| 0| 0| 0| 7| 0| 2| 5| 0| 7| 0| 1| 1| 3| 4| 4| 4| 0| 6| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 1.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | 1 1 | 2 1.0|
Myocardium, Mineralization, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Subcapsular, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + M + + + + + +| 46 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Abscess | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Mandibular, Abscess | 3 | 1 3.0|
Mandibular, Bacterium | X | 1 |
Mandibular, Hyperplasia, Lymphoid | 2| 1 2.0|
Mandibular, Hyperplasia, Plasma Cell | | 1 3.0|
Mandibular, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 8| 3| 0| 0| 3| 6| 3| 3| 3| 2| 3| 3| 3| 6| 0| 3| 3| 3| 3| |
| 9| 7| 0| 0| 0| 0| 7| 0| 2| 5| 0| 7| 0| 1| 1| 3| 4| 4| 4| 0| 6| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| 37 |
Hematopoietic Cell Proliferation | 1 1 2 1 2 1 1 1 1 1| 20 1.4|
Hyperplasia, Lymphoid | 2 3 2 2 | 8 2.8|
Infiltration Cellular, Histiocyte | 1 2 2| 8 1.9|
Sinus, Ectasia | 2 1 2 3 3 2 2 | 14 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 2.0|
Depletion Lymphoid | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 2 1 2 1 | 8 1.5|
Hyperplasia, Lymphoid | 2 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | + + M + + + M + M + + M M + + + + + + + M + + + M| 37 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.1|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.0|
Parasite Metazoan | X X X X X X X X X X X X X X X X X X| 36 |
Sebaceous Gland, Ectasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Artery, Thrombosis | | 1 |
Interstitium, Inflammation, Chronic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 8| 3| 0| 0| 3| 6| 3| 3| 3| 2| 3| 3| 3| 6| 0| 3| 3| 3| 3| |
| 9| 7| 0| 0| 0| 0| 7| 0| 2| 5| 0| 7| 0| 1| 1| 3| 4| 4| 4| 0| 6| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia, Nodular | | 1 1.0|
Duct, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | X | 1 |
Cyst | | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
Nephropathy, Chronic | 3 3 | 10 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 1| 4| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 9| 2| 2| 2| 1| 5| 2| 3| 2| 2| 2| 8| 1| 2| 2| 2| 2| 2| 7| 2|
| 7| 7| 6| 7| 7| 2| 7| 7| 8| 9| 3| 8| 1| 8| 8| 2| 3| 5| 8| 8| 9| 9| 0| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M M + M + + + + + + + + + A + A + + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + M + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | X |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Basophilic Focus | X 3 |
Clear Cell Focus | X X X X X 2 |
Cytomegaly | 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3|
Eosinophilic Focus | 3 |
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Necrosis, Coagulative | 1 3 1 2 2 1 1 |
Thrombosis | X |
Hepatocyte, Necrosis | |
Oval Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Bacterium | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + + |
Gingiva, Inflammation, Chronic Active| |
Pulp, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 1| 4| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 9| 2| 2| 2| 1| 5| 2| 3| 2| 2| 2| 8| 1| 2| 2| 2| 2| 2| 7| 2|
| 7| 7| 6| 7| 7| 2| 7| 7| 8| 9| 3| 8| 1| 8| 8| 2| 3| 5| 8| 8| 9| 9| 0| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + A + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + M + + + M + + +|
Pars Distalis, Hyperplasia, Nodular | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + M + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Preputial Gland | + |
Abscess | 3 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mandibular, Hyperplasia, Plasma Cell | 2 |
Pancreatic, Hematopoietic Cell | |
Proliferation | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 |
Hyperplasia, Lymphoid | 2 2 2 4 |
Infiltration Cellular, Histiocyte | 2 2 3 2 3 |
Sinus, Ectasia | 3 2 3 3 2 2 2 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 1| 4| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 9| 2| 2| 2| 1| 5| 2| 3| 2| 2| 2| 8| 1| 2| 2| 2| 2| 2| 7| 2|
| 7| 7| 6| 7| 7| 2| 7| 7| 8| 9| 3| 8| 1| 8| 8| 2| 3| 5| 8| 8| 9| 9| 0| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 1 1 2 1|
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Thymus | + M M + + + + + M M + M + M M + + M + M + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Parasite Metazoan | X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Artery, Thrombosis | |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Metaplasia, Osseous | |
Nephropathy, Chronic | 2 2 1 2 1 3 2 2 |
Glomerulus, Inflammation, | |
Membranoproliferative | 1 |
Glomerulus, Nephropathy, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 0| 2| 3| 4| 3| 3| 3| 3| 3| 8| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 8| 7| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 5| 1| 1| 1| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + M A + + + + + + + + M + + + M + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X| 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X X X 3 2 | 7 2.7|
Clear Cell Focus | X X | 8 2.0|
Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 48 3.0|
Eosinophilic Focus | 3 3 3 | 4 3.0|
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Necrosis, Coagulative | 1 2 1 1 1 1 1 3 1 | 16 1.4|
Thrombosis | | 1 |
Hepatocyte, Necrosis | 1 | 1 1.0|
Oval Cell, Hyperplasia | 4 | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 3 | 1 3.0|
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 3.0|
Bacterium | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + | 6 |
Gingiva, Inflammation, Chronic Active| 2 | 1 2.0|
Pulp, Inflammation, Chronic Active | 3 3 2 | 4 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 0| 2| 3| 4| 3| 3| 3| 3| 3| 8| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 8| 7| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 5| 1| 1| 1| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 1.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + M + + + + + + + + + M| 44 |
Pars Distalis, Hyperplasia, Nodular | | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicle, Hyperplasia, Nodular | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Abscess | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 0| 2| 3| 4| 3| 3| 3| 3| 3| 8| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 8| 7| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 5| 1| 1| 1| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Mandibular, Hyperplasia, Plasma Cell | | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +| 35 |
Hematopoietic Cell Proliferation | 1 2 1 1 1 1 1| 13 1.1|
Hyperplasia, Lymphoid | 2 | 5 2.4|
Infiltration Cellular, Histiocyte | 3 2 3 3| 9 2.6|
Sinus, Ectasia | 2 3 2 3 1 1 3 3 1 3 3 | 19 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 | 8 1.6|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | M + + M M M M + M + + + M M M M + + + + + + + + +| 29 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0|
Parasite Metazoan | X X X X X X X X X X X X X X X X X X X| 36 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 3 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Artery, Thrombosis | X | 1 |
Interstitium, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 0| 2| 3| 4| 3| 3| 3| 3| 3| 8| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 9| 9| 8| 7| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 5| 1| 1| 1| 4| 4| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 3 2 | 4 2.3|
Infarct | 2 | 1 2.0|
Metaplasia, Osseous | 1 1 | 2 1.0|
Nephropathy, Chronic | 3 2 1| 11 1.9|
Glomerulus, Inflammation, | | |
Membranoproliferative | | 1 1.0|
Glomerulus, Nephropathy, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 7| 5| 7| 3| 5| 7| 6| 7| 7| 6| 1| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 9| 5| 2| 7| 2| 2| 5| 2| 9| 5| 2| 5| 2| 2| 6| 3| 2| 2|
| 1| 7| 1| 7| 7| 1| 7| 4| 3| 7| 0| 7| 8| 9| 8| 1| 9| 8| 1| 5| 8| 2| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + + M M + + M|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X X|
__________________________________________________________________________|
Intestine Large, Rectum | A + M + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + M + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 X X X |
Clear Cell Focus | 3 X |
Cytomegaly | 2 3 2 2 3 2 3 2 3 3 2 3 3 2 3 3 2 3 3 2 2 3 3|
Fatty Change | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1|
Granuloma | |
Necrosis, Coagulative | 1 1 2 1 2 1 2 3 1 2|
Parasite Metazoan | |
Thrombosis | X|
Bile Duct, Hyperplasia | 1 1|
Hepatocyte, Necrosis | 1 1 1 |
Oval Cell, Proliferation | 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + A + + +|
Acinus, Atrophy | 2 |
Artery, Inflammation, Chronic | 4 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | A + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + M + + +|
Mucosa, Mineralization | 1 |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 7| 5| 7| 3| 5| 7| 6| 7| 7| 6| 1| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 9| 5| 2| 7| 2| 2| 5| 2| 9| 5| 2| 5| 2| 2| 6| 3| 2| 2|
| 1| 7| 1| 7| 7| 1| 7| 4| 3| 7| 0| 7| 8| 9| 8| 1| 9| 8| 1| 5| 8| 2| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + M + + + + + M + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M M + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 1 1 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Hypospermia | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + + + + + + + + + + + + A + + +|
Mediastinal, Sinus, Ectasia | |
Sinus, Mandibular, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 2 2 1 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Sinus, Ectasia | 3 2 2 2 2 3 2 2 2 3 4|
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + + A + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 1 2 1|
__________________________________________________________________________|
Thymus | + + + + + + + M M + M + + M + + + + M M + + + M +|
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 7| 5| 7| 3| 5| 7| 6| 7| 7| 6| 1| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 9| 5| 2| 7| 2| 2| 5| 2| 9| 5| 2| 5| 2| 2| 6| 3| 2| 2|
| 1| 7| 1| 7| 7| 1| 7| 4| 3| 7| 0| 7| 8| 9| 8| 1| 9| 8| 1| 5| 8| 2| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | A + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic | |
Parasite Metazoan | X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Alveolus, Inflammation, Acute | |
Artery, Thrombosis | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + A + + +|
Infarct | |
Metaplasia, Osseous | 1 |
Nephropathy, Chronic | 2 |
Glomerulus, Inflammation, | |
Membranoproliferative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 0| 1| 3| 4| 3| 9| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| |
| 9| 2| 9| 2| 6| 0| 8| 0| 1| 0| 0| 0| 0| 1| 2| 1| 1| 1| 4| 8| 4| 4| 4| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | M M M + M + + M M + M + + M M + + + + M + + + + +| 36 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X X X X X | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + A + + + + + + + + + + + M + + + A| 43 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X 3 3 | 8 2.7|
Clear Cell Focus | X X X | 5 3.0|
Cytomegaly | 2 3 3 3 3 3 3 2 3 2 3 2 3 3 3 3 2 3 3 3 3 3 2 3 2| 48 2.6|
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 40 1.1|
Granuloma | 2 | 1 2.0|
Necrosis, Coagulative | 1 2 3 3 1 1 1 1 2 3 3 2 3| 23 1.8|
Parasite Metazoan | X | 1 |
Thrombosis | X X X X X | 6 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Necrosis | 1 | 4 1.0|
Oval Cell, Proliferation | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 1 | 2 1.5|
Artery, Inflammation, Chronic | 3 | 2 3.5|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 0| 1| 3| 4| 3| 9| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| |
| 9| 2| 9| 2| 6| 0| 8| 0| 1| 0| 0| 0| 0| 1| 2| 1| 1| 1| 4| 8| 4| 4| 4| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Pulp, Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Tissue | X | 1 |
Myocardium, Inflammation, Chronic, | | |
Multifocal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + + + M| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + M + + + + M + M + + M M| 41 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Follicle, Hyperplasia, Nodular | 1 1 1 2 1 4 1 2 | 16 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 4| 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Seminiferous Tubule, Atrophy | 4| 1 4.0|
Seminiferous Tubule, Hypospermia | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + + + M| 46 |
Mediastinal, Sinus, Ectasia | 2 | 1 2.0|
Sinus, Mandibular, Ectasia | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 0| 1| 3| 4| 3| 9| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| |
| 9| 2| 9| 2| 6| 0| 8| 0| 1| 0| 0| 0| 0| 1| 2| 1| 1| 1| 4| 8| 4| 4| 4| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 31 |
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 2 2 2 | 14 1.4|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 2 | 2 1.5|
Sinus, Ectasia | 2 2 3 1 3 3 3 2 4 3 2 4 4 | 24 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 1 1 2 2 2| 11 1.6|
__________________________________________________________________________|____________|
Thymus | M + M M M M M + M + M M M + + + M M M M M M + M M| 25 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Parasite Metazoan | X X X X X X X X X X X X X | 29 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | X | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Hypothalamus, Compression | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 2 | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Alveolus, Inflammation, Acute | 3 2 | 2 2.5|
Artery, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 0| 1| 3| 4| 3| 9| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| |
| 9| 2| 9| 2| 6| 0| 8| 0| 1| 0| 0| 0| 0| 1| 2| 1| 1| 1| 4| 8| 4| 4| 4| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infarct | 2| 1 2.0|
Metaplasia, Osseous | 1 1 | 3 1.0|
Nephropathy, Chronic | 3 2 2 1 | 5 2.0|
Glomerulus, Inflammation, | | |
Membranoproliferative | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4| 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 7| 6| 6| 7| 4| 6| 5| 6| 6| 5| 4| 6| 6| 6| 4| 6| 5| 6| 4| 5| 6|
DAY ON TEST | 3| 1| 0| 1| 0| 5| 6| 0| 7| 4| 1| 3| 9| 9| 7| 9| 8| 4| 0| 8| 7| 5| 5| 7| 4|
| 6| 3| 0| 3| 3| 0| 2| 4| 7| 9| 0| 6| 4| 9| 5| 9| 8| 1| 4| 2| 3| 4| 0| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + A + M + + M + + + M + + + + M + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + M + + + + + + A + + + + + + +|
Cyst | X |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X X X X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + M + + A M + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + + + + + A + + M + + + + M + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Cytomegaly | 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Eosinophilic Focus | 2 X 2 X 4 |
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | 1 2 1 2 1 1 2 3 1 1 2 1 1 2|
Thrombosis | X X X X X X|
Bile Duct, Hyperplasia | 1 2 1 2 1 1 3 1 2 1 1 3 1 1 2 2 1 1 1 2|
Hepatocyte, Necrosis | 1 |
Vein, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infarct | 4 3|
Artery, Inflammation, Chronic | 2 3 2 2 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Bacterium | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 7| 6| 6| 7| 4| 6| 5| 6| 6| 5| 4| 6| 6| 6| 4| 6| 5| 6| 4| 5| 6|
DAY ON TEST | 3| 1| 0| 1| 0| 5| 6| 0| 7| 4| 1| 3| 9| 9| 7| 9| 8| 4| 0| 8| 7| 5| 5| 7| 4|
| 6| 3| 0| 3| 3| 0| 2| 4| 7| 9| 0| 6| 4| 9| 5| 9| 8| 1| 4| 2| 3| 4| 0| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Inflammation, Chronic Active | 3 |
Aorta, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Coronary Artery, Inflammation, | |
Chronic | 3 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 1 1 |
Valve, Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + M + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Follicle, Hyperplasia | 4 |
Follicle, Hyperplasia, Nodular | 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + + + + + + + + + + + + + + M|
Mandibular, Abscess | 4 |
Mandibular, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 7| 6| 6| 7| 4| 6| 5| 6| 6| 5| 4| 6| 6| 6| 4| 6| 5| 6| 4| 5| 6|
DAY ON TEST | 3| 1| 0| 1| 0| 5| 6| 0| 7| 4| 1| 3| 9| 9| 7| 9| 8| 4| 0| 8| 7| 5| 5| 7| 4|
| 6| 3| 0| 3| 3| 0| 2| 4| 7| 9| 0| 6| 4| 9| 5| 9| 8| 1| 4| 2| 3| 4| 0| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mandibular, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 |
Sinus, Ectasia | 1 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 2 2 3 3 2 3 3 2 3 3 3 2 2 1 2 2 3 4 3|
__________________________________________________________________________|
Thymus | + I M + M M M M + M + M M + I M I M + M M + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Parasite Metazoan | X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Inflammation, Acute | |
Bronchus, Metaplasia, Squamous | 1 |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Nephropathy, Chronic | 3 2 2 3 2 3 3 3 1 3 2 2 3 3 2 2 3 3 3 3 2 3 2|
Fat, Necrosis | |
Glomerulus, Inflammation, | |
Membranoproliferative | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 7| 4| 4| 5| 5| 5| 6| 5| 6| 5| 4| 6| 4| 6| 6| 5| 6| 6| 5| 6| 6| |
DAY ON TEST | 7| 2| 8| 8| 0| 6| 6| 3| 3| 3| 7| 8| 5| 9| 9| 0| 2| 4| 0| 4| 5| 6| 3| 4| 6| |
| 6| 5| 0| 2| 6| 4| 1| 1| 1| 1| 9| 7| 9| 1| 6| 9| 0| 1| 9| 0| 5| 5| 0| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M M + + M +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M + + A + + + + + M + + + + + +| 41 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + M + M + + + + + +| 43 |
Cyst | | 1 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X X X X X X X| 23 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + + + + + + + + M + + + + + + M A + A A A| 39 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + M + + + + + + + + + + + + M| 43 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Clear Cell Focus | X | 1 |
Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 50 3.0|
Eosinophilic Focus | 4 | 6 3.0|
Fatty Change | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 50 1.1|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Necrosis, Coagulative | 1 1 2 1 1 1 1 3 3 2| 24 1.5|
Thrombosis | X X| 8 |
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 2 1 1 2 1 1| 34 1.4|
Hepatocyte, Necrosis | 1 | 2 1.0|
Vein, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Infarct | 4| 3 3.7|
Artery, Inflammation, Chronic | 1 3 4 4| 8 2.6|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + M M + + M +| 46 |
Abscess | | 1 4.0|
Bacterium | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 7| 4| 4| 5| 5| 5| 6| 5| 6| 5| 4| 6| 4| 6| 6| 5| 6| 6| 5| 6| 6| |
DAY ON TEST | 7| 2| 8| 8| 0| 6| 6| 3| 3| 3| 7| 8| 5| 9| 9| 0| 2| 4| 0| 4| 5| 6| 3| 4| 6| |
| 6| 5| 0| 2| 6| 4| 1| 1| 1| 1| 9| 7| 9| 1| 6| 9| 0| 1| 9| 0| 5| 5| 0| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Mucosa, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Aorta, Inflammation, Chronic Active | 1 | 2 2.0|
Aorta, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 3.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 3 1.0|
Valve, Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcapsular, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + M + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + M M + + M +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + M M + + + + M + + M M M M M +| 38 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M M + + M +| 46 |
Follicle, Hyperplasia | | 1 4.0|
Follicle, Hyperplasia, Nodular | 3 1 2 4| 8 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 7| 4| 4| 5| 5| 5| 6| 5| 6| 5| 4| 6| 4| 6| 6| 5| 6| 6| 5| 6| 6| |
DAY ON TEST | 7| 2| 8| 8| 0| 6| 6| 3| 3| 3| 7| 8| 5| 9| 9| 0| 2| 4| 0| 4| 5| 6| 3| 4| 6| |
| 6| 5| 0| 2| 6| 4| 1| 1| 1| 1| 9| 7| 9| 1| 6| 9| 0| 1| 9| 0| 5| 5| 0| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + M + + + + + + + M M + + M +| 44 |
Mandibular, Abscess | | 1 4.0|
Mandibular, Fibrosis | | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + +| 11 |
Hematopoietic Cell Proliferation | | 3 2.0|
Sinus, Ectasia | 2 2 2 2| 7 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + I + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 1 1 3 2 2 1 2 2 3 2 2 2 3 3| 41 2.4|
__________________________________________________________________________|____________|
Thymus | M + + M + + M + + M M + M M M + + M M M + M + M M| 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 26 1.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
Parasite Metazoan | X X X X X X X X X X X X X| 18 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + M M + + + +| 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolus, Inflammation, Acute | 2 | 1 2.0|
Bronchus, Metaplasia, Squamous | | 1 1.0|
Mediastinum, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + A + + + M + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 7| 4| 4| 5| 5| 5| 6| 5| 6| 5| 4| 6| 4| 6| 6| 5| 6| 6| 5| 6| 6| |
DAY ON TEST | 7| 2| 8| 8| 0| 6| 6| 3| 3| 3| 7| 8| 5| 9| 9| 0| 2| 4| 0| 4| 5| 6| 3| 4| 6| |
| 6| 5| 0| 2| 6| 4| 1| 1| 1| 1| 9| 7| 9| 1| 6| 9| 0| 1| 9| 0| 5| 5| 0| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + M M + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 3.0|
Nephropathy, Chronic | 3 1 3 2 2 2 1 1 2 2 2 3 3 2 2 2 2 3 3 3 3 | 44 2.4|
Fat, Necrosis | 1 | 1 1.0|
Glomerulus, Inflammation, | | |
Membranoproliferative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A A +| 47 |
Inflammation, Chronic Active | | 1 3.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 3| 4| 5| 3| 3| 5| 3| 5| 5| 4| 6| 3| 4| 5| 6| 5| 4| 5| 3| 4|
DAY ON TEST | 3| 2| 4| 9| 0| 7| 9| 0| 6| 5| 1| 7| 3| 0| 9| 2| 4| 9| 7| 2| 3| 7| 1| 8| 4|
| 1| 4| 5| 8| 0| 3| 3| 0| 3| 3| 3| 2| 1| 8| 6| 5| 5| 4| 2| 7| 1| 0| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M A + + A + + + + + + + M M + M M M + M M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | X X X X X X X X X|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + M + + + + + +|
Epithelium, Metaplasia, Squamous | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + A + M M + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X |
Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Eosinophilic Focus | X X X |
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Acute | 3 |
Necrosis, Coagulative | 3 1 1 1 2 3 3 1 1 1 1|
Thrombosis | X X |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 2 1 1 1 |
Hepatocyte, Necrosis | 1 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Acinus, Atrophy | 1 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hemorrhage | 3 |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 3| 4| 5| 3| 3| 5| 3| 5| 5| 4| 6| 3| 4| 5| 6| 5| 4| 5| 3| 4|
DAY ON TEST | 3| 2| 4| 9| 0| 7| 9| 0| 6| 5| 1| 7| 3| 0| 9| 2| 4| 9| 7| 2| 3| 7| 1| 8| 4|
| 1| 4| 5| 8| 0| 3| 3| 0| 3| 3| 3| 2| 1| 8| 6| 5| 5| 4| 2| 7| 1| 0| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Valve, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + M + + +|
Hyperplasia | 1 |
Infarct | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + M + + +|
Infarct | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + M M M + + M M M + M + + +|
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + M + + + + + + + +|
Follicle, Hyperplasia, Nodular | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + M + M + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | 2|
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Sinus, Mandibular, Ectasia | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 2 |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 4 2 2 2 2 3 2 3 3 1 1 3|
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 3| 4| 5| 3| 3| 5| 3| 5| 5| 4| 6| 3| 4| 5| 6| 5| 4| 5| 3| 4|
DAY ON TEST | 3| 2| 4| 9| 0| 7| 9| 0| 6| 5| 1| 7| 3| 0| 9| 2| 4| 9| 7| 2| 3| 7| 1| 8| 4|
| 1| 4| 5| 8| 0| 3| 3| 0| 3| 3| 3| 2| 1| 8| 6| 5| 5| 4| 2| 7| 1| 0| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + M + + + + + + + + M + + M + M M + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Erosion | |
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Parasite Metazoan | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 3 2 2 2 2 3 2 3 2 3 2 2 2 |
Artery, Inflammation, Subacute | |
Glomerulus, Infiltration Cellular, | |
Mononuclear Cell | 2 |
Glomerulus, Inflammation, | |
Membranoproliferative | 1 |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + M + M + + +|
_____________________________________________________________________________________________________________________|
Page 114
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 3| 5| 5| 5| 4| 5| 5| 6| 3| 6| 3| 6| 4| 5| 5| 6| 5| 3| 6| 6| 5| 6| |
DAY ON TEST | 3| 7| 2| 6| 6| 1| 8| 6| 7| 4| 3| 4| 3| 4| 3| 6| 0| 7| 2| 4| 1| 2| 0| 7| 3| |
| 5| 4| 6| 3| 5| 2| 0| 1| 4| 8| 9| 9| 6| 2| 9| 8| 1| 2| 2| 5| 4| 3| 8| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + M + M + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | + M M + + M M M + + + + M + + + + + + M + + + A +| 32 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X X X X X X X X X| 20 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Epithelium, Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + M + + + + + + + + + M + + M + + + + + M M| 40 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + A +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 7 |
Clear Cell Focus | X | 2 |
Cytomegaly | 3 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3| 50 3.0|
Eosinophilic Focus | X | 4 |
Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0|
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Infiltration Cellular, Mixed Cell | 3 | 1 3.0|
Inflammation, Acute | | 1 3.0|
Necrosis, Coagulative | 3 2 3 1 2 2 1 1 2 1 1 1 1 2 3 2 1 2 | 29 1.7|
Thrombosis | X X X X X | 7 |
Bile Duct, Hyperplasia | 2 1 2 2 1 1 1 1 1 1 2 1 1 1| 26 1.2|
Hepatocyte, Necrosis | | 3 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | 3| 1 3.0|
Acinus, Atrophy | | 1 1.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + M + M + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 3| 5| 5| 5| 4| 5| 5| 6| 3| 6| 3| 6| 4| 5| 5| 6| 5| 3| 6| 6| 5| 6| |
DAY ON TEST | 3| 7| 2| 6| 6| 1| 8| 6| 7| 4| 3| 4| 3| 4| 3| 6| 0| 7| 2| 4| 1| 2| 0| 7| 3| |
| 5| 4| 6| 3| 5| 2| 0| 1| 4| 8| 9| 9| 6| 2| 9| 8| 1| 2| 2| 5| 4| 3| 8| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
Hyperkeratosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + +| 2 |
Aorta, Inflammation, Chronic Active | 3 1| 2 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + M + M + M + + + + + + + + + M + + + + +| 46 |
Valve, Inflammation, Chronic Active | 1| 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | | 1 1.0|
Infarct | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
Infarct | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + M + + + + + + + + M + + + M + + + + + M| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + M + M + + + + M + + + + + + + + + M| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + M + M + M + + + M + + + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + M + M + + + + + + + + + + + + + + +| 45 |
Follicle, Hyperplasia, Nodular | 1 2 2 1 2 1 1 | 9 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Myelofibrosis | 2 | 2 2.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 3| 5| 5| 5| 4| 5| 5| 6| 3| 6| 3| 6| 4| 5| 5| 6| 5| 3| 6| 6| 5| 6| |
DAY ON TEST | 3| 7| 2| 6| 6| 1| 8| 6| 7| 4| 3| 4| 3| 4| 3| 6| 0| 7| 2| 4| 1| 2| 0| 7| 3| |
| 5| 4| 6| 3| 5| 2| 0| 1| 4| 8| 9| 9| 6| 2| 9| 8| 1| 2| 2| 5| 4| 3| 8| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + A + + + M + M + M + + + M + + + + + + + + + + +| 42 |
Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Sinus, Mandibular, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + +| 10 |
Hematopoietic Cell Proliferation | | 4 2.0|
Sinus, Ectasia | 3 3 4 4 2| 6 3.2|
__________________________________________________________________________|____________|
Spleen | + + + + + M + M + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 2 3 3 2 3 3 2 3 3 2 3 2 4 4 2 3| 32 2.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M M M M M M + M + + M + M + M + M M + M| 28 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0|
Erosion | 2 | 1 2.0|
Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0|
Parasite Metazoan | X X X X X X X X X X | 21 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + M + M + M + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + M + M + M + + + + + + + + + M + + + + +| 46 |
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + M + M + M + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 2 3 2 3 2 2 3 2 2 2 2 1 3 3| 29 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 11:21:20
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 3| 5| 5| 5| 4| 5| 5| 6| 3| 6| 3| 6| 4| 5| 5| 6| 5| 3| 6| 6| 5| 6| |
DAY ON TEST | 3| 7| 2| 6| 6| 1| 8| 6| 7| 4| 3| 4| 3| 4| 3| 6| 0| 7| 2| 4| 1| 2| 0| 7| 3| |
| 5| 4| 6| 3| 5| 2| 0| 1| 4| 8| 9| 9| 6| 2| 9| 8| 1| 2| 2| 5| 4| 3| 8| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Artery, Inflammation, Subacute | 3 3 | 2 3.0|
Glomerulus, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
Glomerulus, Inflammation, | | |
Membranoproliferative | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
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