TDMS Study 05077-02 Pathology Tables
NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 Facility: Battelle Columbus Laboratory Chemical CAS #: 67774-32-7 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7| DAY ON TEST | 4| 2| 3| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| | 7| 9| 3| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 1| 2| 3| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + M + + + + + + A + + + + + + + + +| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| Hyperplasia | 3 | Ulcer | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | | Clear Cell Focus | X | Eosinophilic Focus | 3 | Hematopoietic Cell Proliferation | | Infiltration Cellular, Mixed Cell | | Necrosis, Coagulative | 4 | __________________________________________________________________________| Mesentery | + + | Hyperplasia, Lymphoid | 2 | Inflammation, Necrotizing | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypoplasia | 4 | Acinus, Atrophy | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Bacterium | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Coronary Artery, Inflammation, | | Chronic | | Myocardium, Inflammation, Chronic, | | Multifocal | 1 | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7| DAY ON TEST | 4| 2| 3| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| | 7| 9| 3| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 1| 2| 3| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Valve, Bacterium | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | 2 2 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | | Zona Reticularis, Vacuolization | | Cytoplasmic | 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Angiectasis | 2 | Pars Distalis, Hyperplasia, Nodular | 2 2 1 1 4| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Hyperplasia, Nodular | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Follicle, Cyst | X X | Periovarian Tissue, Cyst | X X X X X| Rete Ovarii, Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic | 2 3 2 3 2 3 4 3 2 3 3 4 2 3 1 3 4 4 3 3 3 4 3 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Myelofibrosis | 2 2 2 1 | Femoral, Myelofibrosis | 1 2 1 1 1 1 | Sternal, Myelofibrosis | 2 2 3 1 1 2 1 2 2 2 2 2 2 2 2 2 3 2 2 1 4 2| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Infiltration Cellular, | | Histiocyte | 3| Mandibular, Infiltration Cellular, | | Histiocyte | 3| Mediastinal, Hyperplasia, Lymphoid | 2 | Mediastinal, Hyperplasia, Plasma Cell| | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7| DAY ON TEST | 4| 2| 3| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| | 7| 9| 3| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 1| 2| 3| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mediastinal, Infiltration Cellular, | | Histiocyte | 3| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + | Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Histiocyte | 3 | Sinus, Ectasia | 1 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Hyperplasia, Lymphoid | 1 2 2 2 2 3 3| __________________________________________________________________________| Thymus | M + + + + + + + + M + + + + + + + M + + + + + + M| Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M + + + + + + + + + M + + + M + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Parasite Metazoan | X X X X X X X X X X X X X X X| Subcutaneous Tissue, Granuloma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Infarct | | Hypothalamus, Compression | 1 | __________________________________________________________________________| Peripheral Nerve | + | Sciatic, Degeneration | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitium, Inflammation, Chronic | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + | Hyperplasia, Nodular | 1 | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 7| DAY ON TEST | 4| 2| 3| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| | 7| 9| 3| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 8| 1| 1| 1| 1| 2| 3| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 3 2 | Infiltration Cellular, Mixed Cell | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| | | 1| 1| 2| 2| 2| 8| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3| 3| 3| 6| 6| 6| 7| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | A + + + + + + + + + + A + + + + + + + + + A + + +| 45 | Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X| 1 | __________________________________________________________________________|____________| Intestine Small | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + + + + A + + +| 46 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 | Hyperplasia | | 1 3.0| Ulcer | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Basophilic Focus | 3 | 1 3.0| Clear Cell Focus | X | 2 | Eosinophilic Focus | | 1 3.0| Hematopoietic Cell Proliferation | 3 | 1 3.0| Infiltration Cellular, Mixed Cell | 2 | 1 2.0| Necrosis, Coagulative | | 1 4.0| __________________________________________________________________________|____________| Mesentery | | 2 | Hyperplasia, Lymphoid | | 1 2.0| Inflammation, Necrotizing | | 1 2.0| __________________________________________________________________________|____________| Pancreas | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Hypoplasia | | 1 4.0| Acinus, Atrophy | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 4 4 | 2 4.0| Bacterium | X X | 2 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | A + + + + + + + + + + A + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| | | 1| 1| 2| 2| 2| 8| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3| 3| 3| 6| 6| 6| 7| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Coronary Artery, Inflammation, | | | Chronic | 2 | 1 2.0| Myocardium, Inflammation, Chronic, | | | Multifocal | | 1 1.0| Valve, Bacterium | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Hyperplasia | 2 2 | 4 2.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Hyperplasia | 1 | 1 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic | | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | | 1 2.0| Pars Distalis, Hyperplasia, Nodular | 1 1 3 2 2 1 2 | 12 1.8| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Follicle, Hyperplasia, Nodular | 4 | 2 2.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | A + + + + + + + + + + A + + + + + + + + + M + + +| 47 | Cyst | 2 | 1 2.0| Follicle, Cyst | X | 3 | Periovarian Tissue, Cyst | X X X X X X | 11 | Rete Ovarii, Cyst | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Endometrium, Hyperplasia, Cystic | 3 3 3 4 3 4 3 4 2 3 3 3 3 2 2 3 2 3 3 2 4 3| 46 2.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| | | 1| 1| 2| 2| 2| 8| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3| 3| 3| 6| 6| 6| 7| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Calvarium, Myelofibrosis | 1 2 | 6 1.7| Femoral, Myelofibrosis | 1 2 1 1 1 1 1 | 13 1.2| Sternal, Myelofibrosis | 2 2 2 3 1 1 2 1 1 2 3 2 3 2 1 2 2 3 2 3| 42 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + M + + + + + + + + + + + + + M + + +| 48 | Lumbar, Infiltration Cellular, | | | Histiocyte | | 1 3.0| Mandibular, Infiltration Cellular, | | | Histiocyte | | 1 3.0| Mediastinal, Hyperplasia, Lymphoid | | 1 2.0| Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 8 | Hyperplasia, Lymphoid | 2 | 2 2.0| Infiltration Cellular, Histiocyte | | 1 3.0| Sinus, Ectasia | 1 2 | 4 1.3| __________________________________________________________________________|____________| Spleen | A + + + + + + + + + + A + + + + + + + + + + + + +| 48 | Hematopoietic Cell Proliferation | 2 3 1 | 4 2.0| Hyperplasia, Lymphoid | 2 2 1 2 2 3 2 | 14 2.1| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + A + + + + + M + + + M + + +| 43 | Hyperplasia, Lymphoid | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + M + + + + + + + M + + + M + + + + + + + M +| 41 | __________________________________________________________________________|____________| Skin | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1| 23 1.0| Parasite Metazoan | X X X X X X X X X| 24 | Subcutaneous Tissue, Granuloma | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | Infarct | 3 | 1 3.0| Hypothalamus, Compression | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 3| | | 1| 1| 2| 2| 2| 8| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3| 3| 3| 6| 6| 6| 7| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | Sciatic, Degeneration | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitium, Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + + + + | 6 | Hyperplasia, Nodular | 1 | 2 1.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Lymphocyte | | 2 2.5| Infiltration Cellular, Mixed Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + M + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X X | Cytomegaly | 1 1 1 1 1 | Cytoplasmic Alteration | 2 | Eosinophilic Focus | 2 X | Necrosis, Coagulative | 1 | Thrombosis | | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 4 | Duct, Ectasia | 4 4| __________________________________________________________________________| Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | 2 2 2 2 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Zona Reticularis, Vacuolization | | Cytoplasmic | 4 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Nodular | 1 4 4 2 2 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Inflammation, Subacute | | Follicle, Hyperplasia, Nodular | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Bilateral, Periovarian Tissue, Cyst | X | Follicle, Cyst | | Periovarian Tissue, Cyst | X X X X X X X | Rete Ovarii, Cyst | X | __________________________________________________________________________| Oviduct | + | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 3 3 | Endometrium, Hyperplasia, Cystic | 3 4 4 1 2 3 1 3 3 4 4 2 2 3 3 1 1 3 4 4 1 4| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Myelofibrosis | 1 2 2 2 2 2 3 1 1 1| Femoral, Myelofibrosis | 1 1 2 1 2 2 2 1| Myeloid Cell, Hyperplasia | 3 | Sternal, Myelofibrosis | 1 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia, Lymphoid | 2 | Mediastinal, Hematopoietic Cell | | Proliferation | | Sinus, Mandibular, Ectasia | 4 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | Hyperplasia, Lymphoid | 4| Sinus, Ectasia | 2 3 1 2 3 1 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | Hyperplasia, Lymphoid | 2 2 2 2 | Pigmentation | 2 | __________________________________________________________________________| Thymus | M + M + + + + + + + + + M + + + + M + M + + + + +| Atrophy | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperkeratosis | 1 1 2 1 1 1 1 1 1 | Inflammation, Necrotizing | 3 3 | Parasite Metazoan | X X X X X X X X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Hypothalamus, Compression | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 0| 3| 2| | | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 6| 6| 2| 6| 6| 6| 6| 8| 6| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X| 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X| 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Clear Cell Focus | X 1 X | 5 1.0| Cytomegaly | 1 | 6 1.0| Cytoplasmic Alteration | | 1 2.0| Eosinophilic Focus | 2 | 3 2.0| Necrosis, Coagulative | 2 | 2 1.5| Thrombosis | X | 1 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 4 1 | 3 3.0| Duct, Ectasia | 4 | 3 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Subcapsular, Hyperplasia | 2 | 5 2.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 1 | 2 1.5| Zona Reticularis, Vacuolization | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 0| 3| 2| | | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 6| 6| 2| 6| 6| 6| 6| 8| 6| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Cytoplasmic | 4 | 2 4.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + M + + + + + M + + + + + + +| 47 | Pars Distalis, Cyst | X | 1 | Pars Distalis, Hyperplasia, Nodular | 1 2 1 3 2 2 3 3 2 | 16 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 | 2 1.5| Inflammation, Subacute | 1 | 1 1.0| Follicle, Hyperplasia, Nodular | 2 1 4 1 | 5 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Mineralization | | 1 2.0| Bilateral, Periovarian Tissue, Cyst | X | 2 | Follicle, Cyst | X X X | 3 | Periovarian Tissue, Cyst | X X X X X | 12 | Rete Ovarii, Cyst | | 1 | __________________________________________________________________________|____________| Oviduct | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 4 2 | 6 3.2| Endometrium, Hyperplasia, Cystic | 2 4 3 3 3 3 4 4 2 2 3 4 1 2 2 2 1 2 1 2 | 42 2.6| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calvarium, Myelofibrosis | 2 2 2 2 2 2 1 1 1 1 2 | 21 1.7| Femoral, Myelofibrosis | 1 2 1 2 1 2 1 1 2 2 1 1 1 | 21 1.4| Myeloid Cell, Hyperplasia | | 1 3.0| Sternal, Myelofibrosis | | 1 1.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Mandibular, Hyperplasia, Lymphoid | | 1 2.0| Mediastinal, Hematopoietic Cell | | | Proliferation | 3 | 1 3.0| Sinus, Mandibular, Ectasia | | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + +| 21 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 0| 3| 2| | | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 6| 6| 2| 6| 6| 6| 6| 8| 6| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | 1 | 2 1.5| Hyperplasia, Lymphoid | 2 2 | 3 2.7| Sinus, Ectasia | 2 2 2 | 10 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3| 2 3.0| Hyperplasia, Lymphoid | 2 2 2 3 2 | 9 2.1| Pigmentation | 2 | 2 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + M + + + + + + + + +| 43 | Atrophy | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + M + + + + M + + + + + + + + + + M + +| 44 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.1| Hyperkeratosis | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.1| Inflammation, Necrotizing | | 2 3.0| Parasite Metazoan | X X X X X X X X X X X X X X X X X| 28 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Tarsal, Hyperostosis | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | +| 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | Hypothalamus, Compression | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 0| 3| 2| | | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 6| 6| 2| 6| 6| 6| 6| 8| 6| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Infarct | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 3| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 3| 7| 7| 7| 5| 6| 7| 7| DAY ON TEST | 1| 2| 2| 9| 0| 2| 8| 2| 2| 2| 2| 3| 3| 2| 8| 3| 3| 4| 3| 3| 2| 1| 0| 3| 3| | 0| 9| 9| 2| 9| 9| 7| 9| 9| 7| 9| 0| 0| 1| 0| 0| 0| 1| 0| 0| 6| 2| 3| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + A + + + + + + + + + M + + + + + + + + + + +| Epithelium, Inclusion Body | | Intracytoplasmic | 2 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| Ulcer | 4 | __________________________________________________________________________| Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Ulcer | 4 | Peyer's Patch, Infiltration Cellular,| | Histiocyte | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + M + + + + + M + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +| Ulcer | 4 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytomegaly | 1 1 2 1 1 1 | Eosinophilic Focus | X 2 | Fatty Change | 2 | Hematopoietic Cell Proliferation | 1 | Necrosis, Coagulative | 3 1 1| Hepatocyte, Necrosis | 1 1 | __________________________________________________________________________| Mesentery | + + + | Inflammation, Necrotizing | 2 | __________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 3 3 | Duct, Ectasia | 3 | Interlobular, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Bacterium | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Pulmonary Artery, Inflammation, | | Chronic | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 3| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 3| 7| 7| 7| 5| 6| 7| 7| DAY ON TEST | 1| 2| 2| 9| 0| 2| 8| 2| 2| 2| 2| 3| 3| 2| 8| 3| 3| 4| 3| 3| 2| 1| 0| 3| 3| | 0| 9| 9| 2| 9| 9| 7| 9| 9| 7| 9| 0| 0| 1| 0| 0| 0| 1| 0| 0| 6| 2| 3| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Coronary Artery, Inflammation, | | Chronic | | Myocardium, Inflammation, Chronic, | | Multifocal | 1 | Valve, Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 | Hyperplasia | 1 1 | Zona Reticularis, Vacuolization | | Cytoplasmic | 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia, Nodular | 1 1 1 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Follicle, Hyperplasia, Nodular | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | Abscess | | __________________________________________________________________________| Ovary | + + + M + + + + + M + + + + + + + + + + + + + + +| Angiectasis | | Inflammation, Chronic Active | 4 3 | Thrombosis | | Follicle, Cyst | X | Periovarian Tissue, Cyst | X X | Rete Ovarii, Cyst | X X X| __________________________________________________________________________| Oviduct | + + | __________________________________________________________________________| Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +| Angiectasis | 2 | Inflammation, Acute | 3 2 | Inflammation, Granulomatous | | Endometrium, Hyperplasia, Cystic | 2 3 4 1 2 2 2 2 2 1 2 1 2 2 2 3 3 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 3| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 3| 7| 7| 7| 5| 6| 7| 7| DAY ON TEST | 1| 2| 2| 9| 0| 2| 8| 2| 2| 2| 2| 3| 3| 2| 8| 3| 3| 4| 3| 3| 2| 1| 0| 3| 3| | 0| 9| 9| 2| 9| 9| 7| 9| 9| 7| 9| 0| 0| 1| 0| 0| 0| 1| 0| 0| 6| 2| 3| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Myelofibrosis | 1 2 1 1 2 | Femoral, Myelofibrosis | 1 2 1 1 2 | Sternal, Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Hyperplasia, Plasma Cell | 3 | Lumbar, Infiltration Cellular, | | Histiocyte | 4 | Sinus, Mandibular, Ectasia | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + +| Hematopoietic Cell Proliferation | 2 1 1| Hyperplasia, Plasma Cell | 2 | Infiltration Cellular, Histiocyte | 4 | Sinus, Ectasia | 2 1| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 1 3 1 4 | Hyperplasia, Lymphoid | 1 2 | Necrosis, Acute | | __________________________________________________________________________| Thymus | M + + M + + + + M M + + + M + + + M + + M M M + M| Amyloid Deposition | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + M + + M + M + + + M M M + + + + + M M M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Necrotizing | 3 | Parasite Metazoan | X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic | 2 | Artery, Necrosis, Fibrinoid | 2 | Hypothalamus, Compression | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Bronchus, Granuloma | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 3| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 3| 7| 7| 7| 5| 6| 7| 7| DAY ON TEST | 1| 2| 2| 9| 0| 2| 8| 2| 2| 2| 2| 3| 3| 2| 8| 3| 3| 4| 3| 3| 2| 1| 0| 3| 3| | 0| 9| 9| 2| 9| 9| 7| 9| 9| 7| 9| 0| 0| 1| 0| 0| 0| 1| 0| 0| 6| 2| 3| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | Atrophy | | Hyperplasia, Nodular | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Infarct | | Metaplasia, Osseous | 2 | Nephropathy, Chronic | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 2| 3| 7| 2| 3| 3| | | 1| 1| 1| 2| 3| 3| 2| 2| 2| 2| 2| 3| 0| 3| 3| 6| 0| 6| 6| 4| 6| 7| 1| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + A + + + + +| 45 | Epithelium, Inclusion Body | | | Intracytoplasmic | | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 | Ulcer | | 1 4.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 1.0| Ulcer | 3 | 2 3.5| Peyer's Patch, Infiltration Cellular,| | | Histiocyte | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + M + + + + +| 47 | Ulcer | | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cytomegaly | 1 1 1 1 1 1 1 1 | 14 1.1| Eosinophilic Focus | | 2 2.0| Fatty Change | 1 | 2 1.5| Hematopoietic Cell Proliferation | | 1 1.0| Necrosis, Coagulative | 3 1| 5 1.8| Hepatocyte, Necrosis | | 2 1.0| __________________________________________________________________________|____________| Mesentery | + | 4 | Inflammation, Necrotizing | 3 | 2 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | | 2 3.0| Duct, Ectasia | | 1 3.0| Interlobular, Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Abscess | 4 | 1 4.0| Bacterium | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + M + + + + + + + A + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + M + + + + + + + A + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + M + + + + + + + A + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 2| 3| 7| 2| 3| 3| | | 1| 1| 1| 2| 3| 3| 2| 2| 2| 2| 2| 3| 0| 3| 3| 6| 0| 6| 6| 4| 6| 7| 1| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Pulmonary Artery, Inflammation, | | | Chronic | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Coronary Artery, Inflammation, | | | Chronic | 1 | 1 1.0| Myocardium, Inflammation, Chronic, | | | Multifocal | | 1 1.0| Valve, Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 3 | 3 2.0| Hyperplasia | 2 | 3 1.3| Zona Reticularis, Vacuolization | | | Cytoplasmic | 4 2 3 | 4 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + M M + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | 2 | 1 2.0| Pars Distalis, Hyperplasia, Nodular | 1 3 2 3 2 | 9 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 2.0| Follicle, Hyperplasia, Nodular | 2 3 1 | 3 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + | 2 | Abscess | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | 4 | 1 4.0| Inflammation, Chronic Active | 4 | 3 3.7| Thrombosis | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 2| 3| 7| 2| 3| 3| | | 1| 1| 1| 2| 3| 3| 2| 2| 2| 2| 2| 3| 0| 3| 3| 6| 0| 6| 6| 4| 6| 7| 1| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Follicle, Cyst | X | 2 | Periovarian Tissue, Cyst | X X X X X X | 8 | Rete Ovarii, Cyst | | 3 | __________________________________________________________________________|____________| Oviduct | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 2.0| Inflammation, Acute | | 2 2.5| Inflammation, Granulomatous | 2 | 1 2.0| Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 4 1 3 2 1 1 2 2 3 2 3 4 2 2 3| 38 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calvarium, Myelofibrosis | 2 3 1 1 1 2 1 2 | 13 1.5| Femoral, Myelofibrosis | 1 2 1 1 1 1 1 2 | 13 1.3| Sternal, Myelofibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + M + M + + + + + + + + + + + + + + + + + + + +| 48 | Lumbar, Hyperplasia, Plasma Cell | | 1 3.0| Lumbar, Infiltration Cellular, | | | Histiocyte | | 1 4.0| Sinus, Mandibular, Ectasia | 1 2 | 3 2.3| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 | 4 1.3| Hyperplasia, Plasma Cell | | 1 2.0| Infiltration Cellular, Histiocyte | | 1 4.0| Sinus, Ectasia | 2 1 2 1 2 | 7 1.6| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 4 1 | 9 2.0| Hyperplasia, Lymphoid | | 2 1.5| Necrosis, Acute | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + M M + + + + M + M + + M M + + M + M M + +| 31 | Amyloid Deposition | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M + + + + + + + A + + + + + + M + M M + +| 34 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 28 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.0| Inflammation, Necrotizing | | 1 3.0| Parasite Metazoan | X X X X X X X X X X X X X | 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 4| 3| 3| 2| 3| 7| 2| 3| 3| | | 1| 1| 1| 2| 3| 3| 2| 2| 2| 2| 2| 3| 0| 3| 3| 6| 0| 6| 6| 4| 6| 7| 1| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + I + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Artery, Inflammation, Chronic | | 1 2.0| Artery, Necrosis, Fibrinoid | | 1 2.0| Hypothalamus, Compression | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bronchus, Granuloma | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + + | 6 | Atrophy | 1 | 1 1.0| Hyperplasia, Nodular | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Infarct | 2 | 1 2.0| Metaplasia, Osseous | 1 | 2 1.5| Nephropathy, Chronic | 2 2 | 3 1.7| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 1| 2| 2| 3| 2| 2| 2| 2| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| | 9| 7| 9| 9| 0| 9| 9| 9| 9| 0| 0| 9| 0| 0| 6| 0| 0| 0| 1| 1| 4| 1| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Inflammation, Chronic Active | 1 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | X X X X X X X X X 2 X X | Cytomegaly | 3 3 3 3 3 2 3 3 1 3 3 2 1 2 3 3 3 3 3 3 2 3 3 2| Eosinophilic Focus | X 4 X 3 X 3 3 4 3 X | Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Hematopoietic Cell Proliferation | 2 | Necrosis, Coagulative | 2 1 3 2 1 2 1 2 1 3 | Thrombosis | | Bile Duct, Hyperplasia | 1 1 1 1 1 | Hepatocyte, Necrosis | 1 1 1 1 1 1 1 1 1 1 1 1 1| Sinusoid, Congestion | 2 | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic | | Inflammation, Necrotizing | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypoplasia | 4| Necrosis | 3 | Acinus, Atrophy | 4 | Artery, Inflammation, Chronic | 2 | Duct, Ectasia | 2 4 | Interlobular, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Mucocele | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 1| 2| 2| 3| 2| 2| 2| 2| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| | 9| 7| 9| 9| 0| 9| 9| 9| 9| 0| 0| 9| 0| 0| 6| 0| 0| 0| 1| 1| 4| 1| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Ulcer | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Inflammation, Chronic Active | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Myocardium, Inflammation, Acute, | | Multifocal | 1 2 | Myocardium, Mineralization, | | Multifocal | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | 3 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 | Zona Reticularis, Vacuolization | | Cytoplasmic | 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Pars Distalis, Hyperplasia, Nodular | 1 3 2 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Hyperplasia, Nodular | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + M + + + + + + + + + M + + + +| Inflammation, Chronic Active | | Mineralization | | Follicle, Cyst | X X X X | Periovarian Tissue, Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Inflammation, Suppurative | | Endometrium, Hyperplasia, Cystic | 2 3 1 2 2 2 1 1 3 1 2 3 1 2 1 1 2| Endometrium, Endothelium, Metaplasia,| | Squamous | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 1| 2| 2| 3| 2| 2| 2| 2| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| | 9| 7| 9| 9| 0| 9| 9| 9| 9| 0| 0| 9| 0| 0| 6| 0| 0| 0| 1| 1| 4| 1| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Myelofibrosis | 1 | Femoral, Myelofibrosis | 1 2 1 1 | Sternal, Myelofibrosis | 1 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Abscess | 3 | Mandibular, Bacterium | X | Mandibular, Hyperplasia, Lymphoid | | Renal, Infiltration Cellular, | | Histiocyte | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 2 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 3| Infiltration Cellular, Histiocyte | 2 | Sinus, Ectasia | 2 4 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 1 1 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | + M + + M + + + + + + M + + + + + + + + + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + M + + + + + + M + + M + + + M + + + + M M| __________________________________________________________________________| Skin | + M + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 | Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Necrotizing | 2 | Parasite Metazoan | X X X X X X X X X X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Compression | X| Hypothalamus, Compression | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Alveolus, Inflammation, Acute | 1 | Interstitium, Inflammation, Chronic | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 1| 2| 2| 3| 2| 2| 2| 2| 3| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| | 9| 7| 9| 9| 0| 9| 9| 9| 9| 0| 0| 9| 0| 0| 6| 0| 0| 0| 1| 1| 4| 1| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nerve, Inflammation, Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | | Mineralization | 2 | Nephropathy, Chronic | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 0| 6| 6| 3| 3| | | 1| 1| 2| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 6| 0| 6| 0| 6| 4| 2| 1| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + M + + + M + + + + + + + + + + + M + +| 46 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 2 | Clear Cell Focus | X X X X X 3 X X X X| 22 2.5| Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 49 2.8| Eosinophilic Focus | 3 3 X 4 2 2 X 2| 18 3.0| Fatty Change | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0| Hematopoietic Cell Proliferation | 3 2 | 3 2.3| Necrosis, Coagulative | 1 1 2 1 2 4 1 1| 18 1.7| Thrombosis | X | 1 | Bile Duct, Hyperplasia | 1 1 1 1 | 9 1.0| Hepatocyte, Necrosis | 1 1 1 1 1 1 1 1 1 1 | 23 1.0| Sinusoid, Congestion | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + | 3 | Inflammation, Chronic | 3 3 | 2 3.0| Inflammation, Necrotizing | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypoplasia | | 1 4.0| Necrosis | 3 | 2 3.0| Acinus, Atrophy | | 1 4.0| Artery, Inflammation, Chronic | | 1 2.0| Duct, Ectasia | 1 2| 4 2.3| Interlobular, Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 0| 6| 6| 3| 3| | | 1| 1| 2| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 6| 0| 6| 0| 6| 4| 2| 1| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Abscess | | 1 4.0| Mucocele | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 1 2.0| Ulcer | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | Aorta, Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myocardium, Inflammation, Acute, | | | Multifocal | | 2 1.5| Myocardium, Mineralization, | | | Multifocal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 3 | 3 2.7| Zona Reticularis, Vacuolization | | | Cytoplasmic | | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Hyperplasia, Nodular | 1 1 1 | 7 1.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Hyperplasia, Nodular | 3 1 1 4 | 6 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 0| 6| 6| 3| 3| | | 1| 1| 2| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 6| 0| 6| 0| 6| 4| 2| 1| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Mineralization | 1 | 1 1.0| Follicle, Cyst | X X | 6 | Periovarian Tissue, Cyst | X X | 4 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 4 | 1 4.0| Inflammation, Suppurative | 4 | 1 4.0| Endometrium, Hyperplasia, Cystic | 3 4 1 1 3 4 1 1 2 1 2 3 1 1 3| 32 1.9| Endometrium, Endothelium, Metaplasia,| | | Squamous | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calvarium, Myelofibrosis | 2 1 2 1 | 5 1.4| Femoral, Myelofibrosis | 1 2 1 1 1 | 9 1.2| Sternal, Myelofibrosis | 2 1 2 1 1 1 1 1 1 1| 11 1.2| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Abscess | | 1 3.0| Mandibular, Bacterium | | 1 | Mandibular, Hyperplasia, Lymphoid | 4 | 1 4.0| Renal, Infiltration Cellular, | | | Histiocyte | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + +| 21 | Hematopoietic Cell Proliferation | 1 | 5 1.4| Hyperplasia, Lymphoid | 1 3 1 3 | 5 2.0| Hyperplasia, Plasma Cell | | 2 2.5| Infiltration Cellular, Histiocyte | | 1 2.0| Sinus, Ectasia | 1 2 2| 6 2.2| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 4 | 5 2.0| Hyperplasia, Lymphoid | 1 3 3 | 3 2.3| __________________________________________________________________________|____________| Thymus | + + M M + + M + + + M + + + + + + + M + I M + + M| 38 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M M M M + + + + M + + M + M M M + M + M + +| 32 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 44 1.1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0| Inflammation, Necrotizing | | 1 2.0| Parasite Metazoan | X X X X X X X X X X X X X X X X X X X X X| 43 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 0| 6| 6| 3| 3| | | 1| 1| 2| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 6| 0| 6| 0| 6| 4| 2| 1| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cerebrum, Compression | X | 2 | Hypothalamus, Compression | X X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| Alveolus, Inflammation, Acute | | 1 1.0| Interstitium, Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nerve, Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Osseous | 2 | 1 2.0| Mineralization | 2| 2 2.0| Nephropathy, Chronic | 2 2 | 3 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 1| 7| 5| DAY ON TEST | 2| 9| 2| 6| 2| 2| 9| 2| 2| 2| 3| 3| 3| 5| 3| 3| 5| 3| 2| 2| 3| 3| 9| 3| 7| | 9| 4| 9| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| 0| 4| 0| 5| 4| 1| 1| 4| 1| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + M + + + + + + + + + M + M + + + A + +| Epithelium, Inclusion Body | | Intracytoplasmic | 1 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + M + +| Parasite Metazoan | X X | Mucosa, Hyperplasia | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Ulcer | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Ulcer | 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X 1 X X X | Clear Cell Focus | X 2 X X X | Cytomegaly | 3 3 3 3 3 3 3 2 2 2 3 3 2 3 3 3 2 3 3 3 3 3 3 3 | Eosinophilic Focus | 2 3 2 3 3 | Fatty Change | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 | Hematopoietic Cell Proliferation | 2 | Necrosis, Coagulative | 2 1 1 2 1 1 1 1| Thrombosis | | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 1 1 1 2 | Hepatocyte, Necrosis | 1 1 1 1 1 1 | __________________________________________________________________________| Mesentery | + +| Inflammation, Chronic | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1 | Artery, Inflammation, Chronic | 3 | Interlobular, Inflammation, Chronic | 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Hyperplasia | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 1| 7| 5| DAY ON TEST | 2| 9| 2| 6| 2| 2| 9| 2| 2| 2| 3| 3| 3| 5| 3| 3| 5| 3| 2| 2| 3| 3| 9| 3| 7| | 9| 4| 9| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| 0| 4| 0| 5| 4| 1| 1| 4| 1| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Chronic | 1 | Ulcer | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 | Epithelium, Metaplasia, Squamous | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Coronary Artery, Inflammation, | | Chronic | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Zona Reticularis, Vacuolization | | Cytoplasmic | 3 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia, Nodular | 3 1 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Follicle, Hyperplasia, Nodular | 1 2 2 2 1 2 3 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + M + + + + + + + + + + + + + +| Thrombosis | X | Follicle, Cyst | X X | Periovarian Tissue, Cyst | X X X X X | Rete Ovarii, Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + M + + + + + + + + + + + + + +| Inflammation, Chronic | | Thrombosis | | Endometrium, Hyperplasia, Cystic | 1 3 2 2 2 1 1 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 1| 7| 5| DAY ON TEST | 2| 9| 2| 6| 2| 2| 9| 2| 2| 2| 3| 3| 3| 5| 3| 3| 5| 3| 2| 2| 3| 3| 9| 3| 7| | 9| 4| 9| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| 0| 4| 0| 5| 4| 1| 1| 4| 1| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Myelofibrosis | 2 1 | Sternal, Myelofibrosis | 1 1 1 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + +| Sinus, Mandibular, Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 2 2 | Hyperplasia, Lymphoid | 3 | Infiltration Cellular, Histiocyte | 2 2 1 | Inflammation, Granulomatous | | Sinus, Ectasia | 3 1 2 2 2 2 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 | Granuloma | | Hematopoietic Cell Proliferation | 2 3 1 1 | Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Thymus | + M + M + + M + + M + M M M M M + + M M M + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + M + + + + + + + + + M + + + + M M + + M + M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Necrotizing | | Parasite Metazoan | X X X X X X X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypothalamus, Compression | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolus, Infiltration Cellular, | | Histiocyte | 2 | Artery, Thrombosis | X | Interstitium, Inflammation, Chronic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 7| 1| 7| 5| DAY ON TEST | 2| 9| 2| 6| 2| 2| 9| 2| 2| 2| 3| 3| 3| 5| 3| 3| 5| 3| 2| 2| 3| 3| 9| 3| 7| | 9| 4| 9| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0| 0| 4| 0| 5| 4| 1| 1| 4| 1| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Middle Ear, Abscess | | Middle Ear, Bacterium | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3 | Nephropathy, Chronic | 1 1 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +| Inflammation, Acute | 3 | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| 3| 1| 6| 3| 2| 3| 3| 3| | | 1| 1| 3| 2| 2| 2| 2| 2| 8| 2| 3| 2| 3| 3| 3| 1| 1| 6| 8| 3| 6| 4| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + + + + A + + + + A + M A + + + +| 38 | Epithelium, Inclusion Body | | | Intracytoplasmic | | 1 1.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + +| 46 | Parasite Metazoan | | 2 | Mucosa, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + M A + + + + + + + +| 47 | Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + M + + + + +| 46 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + A + + + M + + + A + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A A + + A + + + + +| 47 | Inflammation, Chronic Active | 3 | 1 3.0| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Basophilic Focus | X X | 8 1.0| Clear Cell Focus | X X X X X X X X| 13 2.0| Cytomegaly | 3 3 3 2 3 3 2 3 3 2 2 3 3 3 3 3 3 3 3 3 3 3 2 2 3| 49 2.8| Eosinophilic Focus | X 3 X 1 4 X X 2 2 2 3 | 16 2.5| Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0| Hematopoietic Cell Proliferation | | 1 2.0| Necrosis, Coagulative | 2 | 9 1.3| Thrombosis | X | 1 | Bile Duct, Cyst | 2 | 1 2.0| Bile Duct, Hyperplasia | 1 1 1 1 1| 9 1.1| Hepatocyte, Necrosis | 1 1 1 1 1 1 1 1 1 | 15 1.0| __________________________________________________________________________|____________| Mesentery | | 2 | Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | | 2 1.5| Artery, Inflammation, Chronic | 2 | 2 2.5| Interlobular, Inflammation, Chronic | | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| 3| 1| 6| 3| 2| 3| 3| 3| | | 1| 1| 3| 2| 2| 2| 2| 2| 8| 2| 3| 2| 3| 3| 3| 1| 1| 6| 8| 3| 6| 4| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic | | 1 1.0| Ulcer | 1 | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic | | 1 1.0| Epithelium, Metaplasia, Squamous | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | Aorta, Inflammation, Chronic Active | 1 | 2 1.5| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Coronary Artery, Inflammation, | | | Chronic | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic | 3 | 3 2.7| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 2.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + M + + + + + + + + + + + + + M + + M + + + + +| 47 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + + + + + + + + + + + + + M + + + +| 47 | Pars Distalis, Hyperplasia, Nodular | 2 3 2 3 | 8 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 2.0| Follicle, Hyperplasia, Nodular | 4 1 1 | 11 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| 3| 1| 6| 3| 2| 3| 3| 3| | | 1| 1| 3| 2| 2| 2| 2| 2| 8| 2| 3| 2| 3| 3| 3| 1| 1| 6| 8| 3| 6| 4| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Thrombosis | | 1 | Follicle, Cyst | X X | 4 | Periovarian Tissue, Cyst | X X X X| 9 | Rete Ovarii, Cyst | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic | 2 | 1 2.0| Thrombosis | X | 1 | Endometrium, Hyperplasia, Cystic | 2 1 2 1 3 3 1 1 1 1 1 2 3 3| 24 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Myelofibrosis | 1 2 1| 5 1.4| Sternal, Myelofibrosis | 1 1 1 1 1 1 1 | 11 1.1| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sinus, Mandibular, Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + +| 23 | Hematopoietic Cell Proliferation | 2 2 1 1| 8 1.6| Hyperplasia, Lymphoid | 2 1 | 3 2.0| Infiltration Cellular, Histiocyte | 2| 4 1.8| Inflammation, Granulomatous | 4 | 1 4.0| Sinus, Ectasia | 3 4 2 1 2 2 3 2 | 15 2.3| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Lymphoid | | 1 2.0| Granuloma | 1 | 1 1.0| Hematopoietic Cell Proliferation | 1 2 1 3 | 8 1.8| Hyperplasia, Lymphoid | 1 | 2 2.0| __________________________________________________________________________|____________| Thymus | + + M + + M + + M + + + + + + M M + + + M M M + +| 29 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + M + + + + + + M + M + M + M + + +| 37 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0| Inflammation, Necrotizing | 3 | 1 3.0| Parasite Metazoan | X X X X X X X X X X X X X X X X X X X| 38 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| 3| 1| 6| 3| 2| 3| 3| 3| | | 1| 1| 3| 2| 2| 2| 2| 2| 8| 2| 3| 2| 3| 3| 3| 1| 1| 6| 8| 3| 6| 4| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypothalamus, Compression | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 2.0| Artery, Thrombosis | | 1 | Interstitium, Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | Middle Ear, Abscess | 4 | 1 4.0| Middle Ear, Bacterium | X | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 3.0| Nephropathy, Chronic | 2 1 | 6 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Acute | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 4| 6| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 6| 7| 6| DAY ON TEST | 2| 2| 2| 5| 6| 4| 9| 9| 2| 3| 3| 1| 0| 8| 7| 1| 8| 3| 3| 5| 3| 9| 1| 0| 8| | 9| 9| 9| 6| 7| 5| 2| 2| 9| 0| 5| 7| 6| 4| 6| 7| 8| 0| 0| 5| 1| 7| 7| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + A + + + + + M + + M + + + + + + + + M| Hemorrhage | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + M + + + A M + + + + + + M + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + A A + + + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X | Clear Cell Focus | X X | Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Eosinophilic Focus | 2 3 | Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| Hematopoietic Cell Proliferation | | Necrosis, Coagulative | 3 1 1 3 2 1 2 3 1 2 3 2 1 1| Thrombosis | X X X X | Bile Duct, Hyperplasia | 1 | Hepatocyte, Necrosis | 1 1 | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + M + + + + + + M + + + + + + + + + +| Hemorrhage | 3 | Artery, Inflammation, Chronic | 1 3 | Duct, Ectasia | | Interlobular, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Myocardium, Inflammation, Chronic, | | Multifocal | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 4| 6| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 6| 7| 6| DAY ON TEST | 2| 2| 2| 5| 6| 4| 9| 9| 2| 3| 3| 1| 0| 8| 7| 1| 8| 3| 3| 5| 3| 9| 1| 0| 8| | 9| 9| 9| 6| 7| 5| 2| 2| 9| 0| 5| 7| 6| 4| 6| 7| 8| 0| 0| 5| 1| 7| 7| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + M + + + M M + M M + + + + + + I + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + M M + + + + + + + +| Pars Distalis, Hyperplasia, Nodular | 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Hyperplasia, Nodular | 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + M + +| Mineralization | | Follicle, Cyst | X | Periovarian Tissue, Cyst | | Rete Ovarii, Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic | 1 2 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Myelofibrosis | 1 | Sternal, Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + | Hematopoietic Cell Proliferation | 2 2 2 2 | Hyperplasia, Lymphoid | 4 | Hyperplasia, Plasma Cell | | Sinus, Ectasia | 4 3 3 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 2 3 2 3 3 1 4 2 2 2 1 1 3 4 | __________________________________________________________________________| Thymus | + + + M + + M M M M + + + + M M M + + M + M M M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + M + M + + M M M + + + M + + + + M M + M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 4| 6| 7| 6| 6| 7| 6| 7| 7| 5| 7| 6| 6| 7| 6| DAY ON TEST | 2| 2| 2| 5| 6| 4| 9| 9| 2| 3| 3| 1| 0| 8| 7| 1| 8| 3| 3| 5| 3| 9| 1| 0| 8| | 9| 9| 9| 6| 7| 5| 2| 2| 9| 0| 5| 7| 6| 4| 6| 7| 8| 0| 0| 5| 1| 7| 7| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Infiltration Cellular, Mast Cell | | Parasite Metazoan | X X X X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 3 | Artery, Thrombosis | | Lymphatic, Infiltration Cellular, | | Polymorphonuclear | 3 | Vein, Thrombosis | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Hyperplasia, Nodular | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 1 | Nephropathy, Chronic | 2 1 | Glomerulus, Inflammation, | | Membranoproliferative | 1 | Renal Tubule, Casts Protein | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 5| 4| 3| 3| 3| 5| 5| 0| 4| 0| 1| 3| 1| 2| 1| 2| 3| 3| 3| 3| 3| 1| | | 5| 1| 1| 1| 6| 2| 6| 2| 4| 1| 3| 8| 9| 1| 2| 0| 5| 7| 7| 1| 3| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 45 | Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 7 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + A + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 45 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + A + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 1 3.0| Basophilic Focus | X X| 3 | Clear Cell Focus | 2 3 | 4 2.5| Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3| 50 3.0| Eosinophilic Focus | 2 2 | 4 2.3| Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| Necrosis, Coagulative | 2 2 2 1 1 2 3 2 3 1 3 1 2 3 3 2 2 | 31 2.0| Thrombosis | X X X | 7 | Bile Duct, Hyperplasia | 1 1 1 1 1 | 6 1.0| Hepatocyte, Necrosis | 1 1 | 4 1.0| __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemorrhage | | 1 3.0| Artery, Inflammation, Chronic | 2 2 1 2 | 6 1.8| Duct, Ectasia | 4 4 | 2 4.0| Interlobular, Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + M + + + + M + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 5| 4| 3| 3| 3| 5| 5| 0| 4| 0| 1| 3| 1| 2| 1| 2| 3| 3| 3| 3| 3| 1| | | 5| 1| 1| 1| 6| 2| 6| 2| 4| 1| 3| 8| 9| 1| 2| 0| 5| 7| 7| 1| 3| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myocardium, Inflammation, Chronic, | | | Multifocal | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + + + + + M M + + + +| 44 | Pars Distalis, Hyperplasia, Nodular | 3 3 | 4 2.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicle, Hyperplasia, Nodular | 4 1 1 1 2 2 2 2 2| 15 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | 2 | 1 2.0| Follicle, Cyst | X | 2 | Periovarian Tissue, Cyst | X X X X | 4 | Rete Ovarii, Cyst | X X| 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Endometrium, Hyperplasia, Cystic | 1 2 1 1 1 1 3 | 11 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Myelofibrosis | | 1 1.0| Sternal, Myelofibrosis | 1 1 | 2 1.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + M + + + + + + + + + + + + + + + + + M| 47 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 20 | Hematopoietic Cell Proliferation | 3 1 2 | 7 2.0| Hyperplasia, Lymphoid | 4 1 | 3 3.0| Hyperplasia, Plasma Cell | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 5| 4| 3| 3| 3| 5| 5| 0| 4| 0| 1| 3| 1| 2| 1| 2| 3| 3| 3| 3| 3| 1| | | 5| 1| 1| 1| 6| 2| 6| 2| 4| 1| 3| 8| 9| 1| 2| 0| 5| 7| 7| 1| 3| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Sinus, Ectasia | 2 2 3 3 2 2 2 | 13 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 1 1 2 2 1 1 | 23 2.0| __________________________________________________________________________|____________| Thymus | M + M + + + + + M M + M M + + M M M + + + + M + M| 27 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M M + M + M M + M M + + M M M M M + M + + M| 26 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 43 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0| Infiltration Cellular, Mast Cell | 2 | 1 2.0| Parasite Metazoan | X X X X X X X X X X X X X X X X X X X X X X| 41 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | | 1 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 3.0| Artery, Thrombosis | X X | 2 | Lymphatic, Infiltration Cellular, | | | Polymorphonuclear | | 1 3.0| Vein, Thrombosis | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Hyperplasia, Nodular | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Osseous | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 6| 5| 6| 7| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 5| 4| 3| 3| 3| 5| 5| 0| 4| 0| 1| 3| 1| 2| 1| 2| 3| 3| 3| 3| 3| 1| | | 5| 1| 1| 1| 6| 2| 6| 2| 4| 1| 3| 8| 9| 1| 2| 0| 5| 7| 7| 1| 3| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Nephropathy, Chronic | 3 2 3 | 5 2.2| Glomerulus, Inflammation, | | | Membranoproliferative | 1 | 2 1.0| Renal Tubule, Casts Protein | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 3| 6| 6| 5| 6| 6| 6| 6| 6| 5| 6| 5| 5| 4| 5| 5| 5| 6| 6| 6| 6| 4| 6| 6| 5| DAY ON TEST | 6| 2| 0| 6| 4| 8| 1| 3| 7| 3| 2| 1| 9| 9| 9| 0| 7| 3| 3| 6| 7| 4| 3| 5| 7| | 5| 2| 6| 1| 1| 3| 7| 6| 8| 2| 0| 5| 2| 1| 5| 8| 6| 3| 4| 0| 1| 0| 5| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + M + M + M A + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X X X X X X X X X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + A M + + + + + + M + + + M + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + A + + + + + + A + + M + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X | Cyst | X | Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Eosinophilic Focus | | Fatty Change | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Hematopoietic Cell Proliferation | 2 | Necrosis, Coagulative | 3 2 3 3 1 1 2 3 2 1 2 1 1 2 1 3 2 | Thrombosis | X X X X X | Bile Duct, Cyst | 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 1 1 2 3 1 2 1 2 3 1 3 1 1 2 2 2| Hepatocyte, Necrosis | 1 1 1 | __________________________________________________________________________| Mesentery | | Inflammation, Chronic | | __________________________________________________________________________| Pancreas | + + M + + + + + + A + + + + + + + + + + + + + +| Infarct | 4 | Artery, Inflammation, Chronic | 3 4 2 1 3 4 3 | __________________________________________________________________________| Salivary Glands | + + M + + + + + + + + + + + + + M + + + + + M +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 2 | __________________________________________________________________________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Inflammation, Chronic Active | 1 | __________________________________________________________________________| Heart | + + M + + + + + + + + + + + + + + + + + + + + +| Atrium, Dilatation | 4 | Coronary Artery, Inflammation, | | Chronic | 2 | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 3| 6| 6| 5| 6| 6| 6| 6| 6| 5| 6| 5| 5| 4| 5| 5| 5| 6| 6| 6| 6| 4| 6| 6| 5| DAY ON TEST | 6| 2| 0| 6| 4| 8| 1| 3| 7| 3| 2| 1| 9| 9| 9| 0| 7| 3| 3| 6| 7| 4| 3| 5| 7| | 5| 2| 6| 1| 1| 3| 7| 6| 8| 2| 0| 5| 2| 1| 5| 8| 6| 3| 4| 0| 1| 0| 5| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Myocardium, Inflammation, Chronic, | | Multifocal | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | 2 2 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Infarct | 4 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + M M + + + + + + A + + + + + + + + + M + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + M + + M + + +| __________________________________________________________________________| Pituitary Gland | + + M + + + + + + + + + + + + + M + M + M M + +| __________________________________________________________________________| Thyroid Gland | + + M + + + + + + + + + + + + + + M + + + + + +| Follicle, Hyperplasia, Nodular | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + M + + + M + + + + + + + + + + + +| Mineralization | | Follicle, Cyst | | Periovarian Tissue, Cyst | X | Rete Ovarii, Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation | 2 | Endometrium, Hyperplasia, Cystic | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + M + + + + + + + + + + + + + M + + M + + + +| Mandibular, Hyperplasia, Lymphoid | 2 | Pancreatic, Sinus, Ectasia | | Sinus, Mandibular, Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + | Hematopoietic Cell Proliferation | 1 | Infiltration Cellular, Histiocyte | 2 | Sinus, Ectasia | 3 4 2 | __________________________________________________________________________| Spleen | + + M + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 2 1 3 2 3 2 1 3 3 2 2 2 3 2 3 3 2| Hyperplasia, Lymphoid | | Pigmentation | 2 | __________________________________________________________________________| Thymus | M M M M M M + M M M M + M M + M + + I + + M + +| _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 3| 6| 6| 5| 6| 6| 6| 6| 6| 5| 6| 5| 5| 4| 5| 5| 5| 6| 6| 6| 6| 4| 6| 6| 5| DAY ON TEST | 6| 2| 0| 6| 4| 8| 1| 3| 7| 3| 2| 1| 9| 9| 9| 0| 7| 3| 3| 6| 7| 4| 3| 5| 7| | 5| 2| 6| 1| 1| 3| 7| 6| 8| 2| 0| 5| 2| 1| 5| 8| 6| 3| 4| 0| 1| 0| 5| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Ectopic Parathyroid Gland | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M + + + + + + M + + + + M + M + M M + + M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Parasite Metazoan | X X X X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + M + + + + + + + + + + + + + + + + + + + + +| Alveolus, Infiltration Cellular, | | Histiocyte | 1 | Interstitium, Inflammation, Chronic | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Hyperplasia, Nodular | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Osseous | 2 | Nephropathy, Chronic | 2 2 2 1 3 2 3 2| Glomerulus, Inflammation, | | Membranoproliferative | 1 | Glomerulus, Nephropathy, Chronic | 2 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 4| 5| 5| 3| 4| 5| 5| 5| 6| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 7| 1| 8| 7| 8| 2| 3| 5| 7| 1| 1| 4| 8| 9| 8| 8| 1| 8| 3| 9| 3| 0| 0| 0| 3| | | 3| 9| 4| 5| 4| 9| 3| 9| 0| 5| 9| 4| 3| 9| 9| 5| 3| 0| 3| 5| 0| 5| 5| 6| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M M + + + + + + M + + + + + + + + + + + + + + M +| 44 | __________________________________________________________________________|____________| Gallbladder | + + + + M + + + M + + + + + + M + + + + + + + M +| 39 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + M + + + + + + + + + + + + + + + M + + + +| 45 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | M M + + M + + + + + + + + + + + M + + + M + + + +| 44 | Parasite Metazoan | X X X X X X X X X | 22 | __________________________________________________________________________|____________| Intestine Large, Rectum | A + + M + + + + + + + + + + + + M + + + + + + + +| 45 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Small | + + + + A + + + + + + + + + + + A + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + M + + + + + + + + + + M A M + + + + + A +| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | M + A + M + + + + + + A + + + + A + + + M + + + +| 39 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + A + + + + A + + + M + + + +| 41 | __________________________________________________________________________|____________| Liver | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | Clear Cell Focus | | 1 | Cyst | X | 2 | Cytomegaly | 3 3 3 3 3 3 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 48 3.0| Eosinophilic Focus | 2 3 X 4| 4 3.0| Fatty Change | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.1| Hematopoietic Cell Proliferation | | 1 2.0| Necrosis, Coagulative | 2 1 1 2 1 1 3 2 1 1 1 2 1 1 1 1 1 | 34 1.6| Thrombosis | X | 6 | Bile Duct, Cyst | | 1 2.0| Bile Duct, Hyperplasia | 2 2 2 2 1 2 2 1 2 2 2 2 3 1 1 1 1| 40 1.8| Hepatocyte, Necrosis | 1 1 1 1 1 1 1 | 10 1.0| __________________________________________________________________________|____________| Mesentery | + | 1 | Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + M + + + A + + + + + + A M M + + + M + + +| 41 | Infarct | | 1 4.0| Artery, Inflammation, Chronic | 4 | 8 3.0| __________________________________________________________________________|____________| Salivary Glands | M M + + + M + + + + + + + M + + + M + + + + + M +| 40 | __________________________________________________________________________|____________| Stomach | + + + + M + + + + + + + + + + M + M + + + + + M +| 45 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + M + + + + + + + + + + M + M + + + + + M +| 45 | Hyperkeratosis | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + M + + + + + + + + + + M + M + + + + + M +| 44 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 4| 5| 5| 3| 4| 5| 5| 5| 6| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 7| 1| 8| 7| 8| 2| 3| 5| 7| 1| 1| 4| 8| 9| 8| 8| 1| 8| 3| 9| 3| 0| 0| 0| 3| | | 3| 9| 4| 5| 4| 9| 3| 9| 0| 5| 9| 4| 3| 9| 9| 5| 3| 0| 3| 5| 0| 5| 5| 6| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Aorta, Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Heart | M + + + M + + + + + + + + + + + + + + + + + + M +| 45 | Atrium, Dilatation | | 1 4.0| Coronary Artery, Inflammation, | | | Chronic | | 1 2.0| Myocardium, Inflammation, Chronic, | | | Multifocal | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + M + + + + + + + + + + M + + + + M + + +| 44 | Subcapsular, Hyperplasia | 1 | 3 1.7| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + M + + + + + + + + + + M + + + + M + + +| 43 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Infarct | | 1 4.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + M + + + + + + + + + + M + + + + M + + +| 43 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + M + + + A + + + + + + A M M + + + M + + +| 39 | __________________________________________________________________________|____________| Parathyroid Gland | M M + + + M + + M + + + + M + + + + + + + + + + +| 41 | __________________________________________________________________________|____________| Pituitary Gland | M M + + + M + + M + + + + + + M + M + + + I + M +| 36 | __________________________________________________________________________|____________| Thyroid Gland | M M + + + M + + + + + + + + + + + + + + + + + M +| 43 | Follicle, Hyperplasia, Nodular | 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + M + + + + + + + + + + + M + + + + + + + +| 45 | Mineralization | 3 | 1 3.0| Follicle, Cyst | X | 1 | Periovarian Tissue, Cyst | | 1 | Rete Ovarii, Cyst | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | Pigmentation | | 1 2.0| Endometrium, Hyperplasia, Cystic | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + M + + + M + + + + + + + + + + + M + + + + + M +| 42 | Mandibular, Hyperplasia, Lymphoid | | 1 2.0| Pancreatic, Sinus, Ectasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 4| 5| 5| 3| 4| 5| 5| 5| 6| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 7| 1| 8| 7| 8| 2| 3| 5| 7| 1| 1| 4| 8| 9| 8| 8| 1| 8| 3| 9| 3| 0| 0| 0| 3| | | 3| 9| 4| 5| 4| 9| 3| 9| 0| 5| 9| 4| 3| 9| 9| 5| 3| 0| 3| 5| 0| 5| 5| 6| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Sinus, Mandibular, Ectasia | 1| 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + +| 7 | Hematopoietic Cell Proliferation | 2| 2 1.5| Infiltration Cellular, Histiocyte | | 1 2.0| Sinus, Ectasia | 3 1 | 5 2.6| __________________________________________________________________________|____________| Spleen | + + + + M + + + + + + + + + + M + M + + + M + + +| 44 | Hematopoietic Cell Proliferation | 3 1 1 2 2 2 2 1 3 2 2 1 1 2 2 1 2| 37 2.1| Hyperplasia, Lymphoid | 2 | 1 2.0| Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Thymus | M + M M M M + + M + + + + M M + M I M + + M M M +| 20 | Ectopic Parathyroid Gland | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M + M M M M M M M M + M M M M M M + + + + M +| 23 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0| Parasite Metazoan | X X X X X X X X X X X X X X X X X| 33 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | M M + + + M + + + + + + + + + + + + + + + + + M +| 44 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | M + + + + + + + + + + + + + + + + + + + + + + M +| 46 | Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 1.0| Interstitium, Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | M M + + + M + + + + + + + + + + + + + + + + + M +| 44 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | Hyperplasia, Nodular | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + M + + + + + + + + + + + M + + + + M + + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 4| 5| 5| 3| 4| 5| 5| 5| 6| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | DAY ON TEST | 7| 1| 8| 7| 8| 2| 3| 5| 7| 1| 1| 4| 8| 9| 8| 8| 1| 8| 3| 9| 3| 0| 0| 0| 3| | | 3| 9| 4| 5| 4| 9| 3| 9| 0| 5| 9| 4| 3| 9| 9| 5| 3| 0| 3| 5| 0| 5| 5| 6| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Metaplasia, Osseous | | 1 2.0| Nephropathy, Chronic | 2 1 2 3 1 3 1 2 | 16 2.0| Glomerulus, Inflammation, | | | Membranoproliferative | | 1 1.0| Glomerulus, Nephropathy, Chronic | | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A + A + + + + M + + + + + + A +| 45 | Parasite Metazoan | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 3| 4| 4| 3| 5| 4| 2| 5| 4| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| DAY ON TEST | 5| 8| 9| 8| 8| 6| 7| 4| 1| 1| 0| 9| 3| 4| 3| 1| 1| 0| 1| 2| 1| 3| 0| 0| 0| | 4| 9| 5| 0| 4| 9| 0| 2| 2| 5| 1| 1| 3| 5| 3| 1| 9| 6| 5| 0| 2| 3| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + M + M + M + + + M A + A + + + M + + M M| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + + + + + +| Parasite Metazoan | X X X X X X X X X | __________________________________________________________________________| Intestine Large, Rectum | M + + + + + + + + + + + + + + M + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + A + M +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + I +| Clear Cell Focus | X 1 X | Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Eosinophilic Focus | 3 X 3 3 3 3 | Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hematopoietic Cell Proliferation | | Necrosis, Coagulative | 2 2 2 1 1 1 2 1 | Thrombosis | X X | Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 | Hepatocyte, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Artery, Inflammation, Chronic | 1 1 | Interlobular, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 | Hyperkeratosis | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + M +| Subcapsular, Hyperplasia | 1 1 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + M +| Hematopoietic Cell Proliferation | 2 1 | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 3| 4| 4| 3| 5| 4| 2| 5| 4| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| DAY ON TEST | 5| 8| 9| 8| 8| 6| 7| 4| 1| 1| 0| 9| 3| 4| 3| 1| 1| 0| 1| 2| 1| 3| 0| 0| 0| | 4| 9| 5| 0| 4| 9| 0| 2| 2| 5| 1| 1| 3| 5| 3| 1| 9| 6| 5| 0| 2| 3| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + + + + M + + + + + M + + + + + M + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + +| Follicle, Hyperplasia, Nodular | 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + M + + + +| Periovarian Tissue, Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | M + + + + + + + + + + + + + + M + + + + + + M +| Mandibular, Hematopoietic Cell | | Proliferation | 2 | Mandibular, Hyperplasia, Lymphoid | 2 | Sinus, Mandibular, Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + | Hematopoietic Cell Proliferation | 2 2 2 2 2 | Sinus, Ectasia | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 3 3 1 2 1 2 2 3 2 1 2 3 2 | __________________________________________________________________________| Thymus | M M + + + + + + + M + + M + + M + + + + M + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M + + + + + M + + + M + + + M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Parasite Metazoan | X X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 3| 4| 4| 3| 5| 4| 2| 5| 4| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| DAY ON TEST | 5| 8| 9| 8| 8| 6| 7| 4| 1| 1| 0| 9| 3| 4| 3| 1| 1| 0| 1| 2| 1| 3| 0| 0| 0| | 4| 9| 5| 0| 4| 9| 0| 2| 2| 5| 1| 1| 3| 5| 3| 1| 9| 6| 5| 0| 2| 3| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + M + + + + + + + +| Inflammation, Chronic | 1 | Interstitium, Inflammation, Chronic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 2 2 1 1 2 2 2 2 2 3 1 2 | __________________________________________________________________________| Urinary Bladder | M + + + + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 6| 5| 5| 6| 3| 3| 5| 4| 5| 5| 4| 3| 3| 3| 5| 4| 5| 5| 6| 5| 5| 4| | DAY ON TEST | 1| 9| 3| 2| 1| 1| 0| 8| 8| 3| 7| 7| 5| 9| 4| 5| 6| 1| 6| 1| 0| 1| 5| 3| 6| | | 9| 2| 3| 0| 9| 2| 6| 9| 9| 8| 7| 1| 7| 8| 7| 0| 4| 5| 3| 2| 1| 9| 4| 7| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + M + M + + M + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Gallbladder | M + + + M M M M + + + + + + + + + + + + + + + + +| 35 | __________________________________________________________________________|____________| Intestine Large | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | M + + + + M + + + M + + + + + + + + + + + + + + +| 45 | Parasite Metazoan | X X | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | M + + + + M + + + M + + + + + + + + + + + + + + +| 45 | Parasite Metazoan | X X X X X X X X | 17 | __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Small | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | M + M + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | M + + + + M + + + M + M + + + + + + + A + + + + +| 41 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | M + + + + M + A + + + + + + + A + + + + + + + + +| 45 | __________________________________________________________________________|____________| Liver | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Clear Cell Focus | | 3 1.0| Cytomegaly | 3 3 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 47 3.0| Eosinophilic Focus | 3 3 | 8 3.0| Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0| Hematopoietic Cell Proliferation | 2 2 | 2 2.0| Necrosis, Coagulative | 2 3 2 3 3 4 1 1 1 1 2 1| 20 1.8| Thrombosis | X X X X | 6 | Bile Duct, Hyperplasia | 2 1 1 1 1 2 1 1 2 3 2 1 1 1 1 1 2 1 2 1 | 37 1.3| Hepatocyte, Necrosis | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Pancreas | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 | Hemorrhage | 2 | 1 2.0| Artery, Inflammation, Chronic | 3 2 | 4 1.8| Interlobular, Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Stomach | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach, Forestomach | M + M + + + + + + + + + + + + + + + + + + + + + +| 46 | Acanthosis | | 1 3.0| Hyperkeratosis | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | M + M + + + + + + + + + + + + + + + + + + + + + +| 45 | Ulcer | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | M + M + M + + M + + + + + + + + + + + + + + + + +| 45 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 6| 5| 5| 6| 3| 3| 5| 4| 5| 5| 4| 3| 3| 3| 5| 4| 5| 5| 6| 5| 5| 4| | DAY ON TEST | 1| 9| 3| 2| 1| 1| 0| 8| 8| 3| 7| 7| 5| 9| 4| 5| 6| 1| 6| 1| 0| 1| 5| 3| 6| | | 9| 2| 3| 0| 9| 2| 6| 9| 9| 8| 7| 1| 7| 8| 7| 0| 4| 5| 3| 2| 1| 9| 4| 7| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Subcapsular, Hyperplasia | 1 1 | 4 1.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hematopoietic Cell Proliferation | | 2 1.5| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Islets, Pancreatic | M + M + + M + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + M + + M + + + + + + + + + + + + + M + +| 41 | __________________________________________________________________________|____________| Pituitary Gland | M + M + M + + M M + + + + + + M + + + M + + + + +| 38 | __________________________________________________________________________|____________| Thyroid Gland | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 | Follicle, Hyperplasia, Nodular | 1 1 1 1 1 | 9 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + M + + + + + + + + + + + + + + + M + + + + + +| 46 | Periovarian Tissue, Cyst | X | 1 | __________________________________________________________________________|____________| Uterus | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 | Endometrium, Hyperplasia, Cystic | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + | 2 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Myeloid Cell, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | M M M + M + + M + + + + + + + + + + + + + + + + +| 41 | Mandibular, Hematopoietic Cell | | | Proliferation | | 1 2.0| Mandibular, Hyperplasia, Lymphoid | | 1 2.0| Sinus, Mandibular, Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 10 | Hematopoietic Cell Proliferation | 3 2 2 | 8 2.1| Sinus, Ectasia | 2 | 2 2.5| __________________________________________________________________________|____________| Spleen | M + M + + + + + + + + + + + + + + + + + + + + + +| 47 | Hematopoietic Cell Proliferation | 3 3 1 3 2 2 2 2 2 2 1 3 2 1| 29 2.1| __________________________________________________________________________|____________| Thymus | M M M + M + + M + + + + + + + M + + + + M M M M +| 32 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M + + + + M M M M M + M M + M M M + + M M M M| 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 59 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 6| 5| 5| 6| 3| 3| 5| 4| 5| 5| 4| 3| 3| 3| 5| 4| 5| 5| 6| 5| 5| 4| | DAY ON TEST | 1| 9| 3| 2| 1| 1| 0| 8| 8| 3| 7| 7| 5| 9| 4| 5| 6| 1| 6| 1| 0| 1| 5| 3| 6| | | 9| 2| 3| 0| 9| 2| 6| 9| 9| 8| 7| 1| 7| 8| 7| 0| 4| 5| 3| 2| 1| 9| 4| 7| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + M + + + + + M| 47 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0| Parasite Metazoan | X X X X X X X X X X X X X X X X X | 31 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 | Inflammation, Chronic | | 1 1.0| Interstitium, Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | M + + + M + + M + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Trachea | M + M + M + + M + + + + + + + + + + + + + + + + +| 44 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Nephropathy, Chronic | 2 2 1 2 1 2 3 1 3 2 2 1 2 1 1 2 2| 29 1.8| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 60 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| DAY ON TEST | 2| 3| 2| 2| 6| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0| 3| 0| | 7| 5| 7| 7| 7| 7| 7| 8| 8| 7| 8| 1| 8| 8| 9| 9| 9| 9| 9| 2| 0| 1| 5| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + M + + + + A + + + + + + + + M + + + + + +| Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Cyst | 2 | Eosinophilic Focus | 2 | Fatty Change | 3 2 | Granuloma | 1 | Hematopoietic Cell Proliferation | | Necrosis, Coagulative | | __________________________________________________________________________| Mesentery | | Inflammation, Acute | | Inflammation, Chronic | | Inflammation, Necrotizing | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Artery, Inflammation, Chronic | 3 | Interlobular, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 1 | Hyperkeratosis | 2 1 | Inflammation, Necrotizing | 2 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Tissue | 2 | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| DAY ON TEST | 2| 3| 2| 2| 6| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0| 3| 0| | 7| 5| 7| 7| 7| 7| 7| 8| 8| 7| 8| 1| 8| 8| 9| 9| 9| 9| 9| 2| 0| 1| 5| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Coronary Artery, Inflammation, | | Chronic | | Epicardium, Inflammation, Chronic | 1 1 | Myocardium, Inflammation, Chronic, | | Multifocal | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + M + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | 2 2 1 | __________________________________________________________________________| Adrenal Gland, Cortex | + M + + + + + + + + + + + + + + +| Hyperplasia | 2 | Infarct | | Zona Glomerulosa, Cytoplasmic | | Alteration | | __________________________________________________________________________| Adrenal Gland, Medulla | + M + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + I + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + M + + + + + M + M + + + + + + + + + M M +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + | Abscess | 3 4 | Duct, Dilatation | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Inflammation, Necrotizing | | __________________________________________________________________________| Seminal Vesicle | + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Tunic, Inflammation, Necrotizing | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Sinus, Ectasia | | Mandibular, Abscess | | Mandibular, Bacterium | | Mediastinal, Hematopoietic Cell | | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| DAY ON TEST | 2| 3| 2| 2| 6| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0| 3| 0| | 7| 5| 7| 7| 7| 7| 7| 8| 8| 7| 8| 1| 8| 8| 9| 9| 9| 9| 9| 2| 0| 1| 5| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Proliferation | | Mediastinal, Hyperplasia, Plasma Cell| | Sinus, Mandibular, Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | Hematopoietic Cell Proliferation | 3 2 2 2 2 1 2 3 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | | Inflammation, Granulomatous | 2 | Sinus, Ectasia | 1 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 3 | Hematopoietic Cell Proliferation | 2 3 3| Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Thymus | + M + M + + M M M + I + M + + + M M + M + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Parasite Metazoan | X X X X X X X X X X X| Subcutaneous Tissue, Fat, Necrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Hyperostosis | X X X | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | | Alveolus, Infiltration Cellular, | | Histiocyte | 2 | Artery, Thrombosis | X | Bronchus, Foreign Body | | Interstitium, Inflammation, Chronic | 1 | Mediastinum, Inflammation, Chronic | | Active | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| DAY ON TEST | 2| 3| 2| 2| 6| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0| 3| 0| | 7| 5| 7| 7| 7| 7| 7| 8| 8| 7| 8| 1| 8| 8| 9| 9| 9| 9| 9| 2| 0| 1| 5| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Harderian Gland | + +| Inflammation, Necrotizing | 4| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Nephropathy, Chronic | 1 1 2 2 1 | Artery, Inflammation, Subacute | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Parasite Metazoan | | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 5| 2| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| | DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 0| 9| 3| 3| 3| 3| 1| 4| 3| 4| 3| 5| | | 0| 4| 8| 0| 0| 0| 1| 3| 1| 1| 1| 8| 1| 4| 1| 4| 4| 4| 4| 4| 5| 4| 1| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + M + + + M + A + M + M + + A + + + + M + + A M +| 38 | Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + M + +| 47 | Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + M + M + + + + + + + + + +| 47 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + + + + + M + + + + + + + A + +| 47 | Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Inflammation, Chronic Active | | 2 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 3 2 | 2 2.5| Cyst | | 1 2.0| Eosinophilic Focus | 2 2 | 3 2.0| Fatty Change | | 2 2.5| Granuloma | | 1 1.0| Hematopoietic Cell Proliferation | 1 | 1 1.0| Necrosis, Coagulative | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + + + | 5 | Inflammation, Acute | 4 | 1 4.0| Inflammation, Chronic | 2 | 1 2.0| Inflammation, Necrotizing | 2 4 | 2 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 4 | 1 4.0| Artery, Inflammation, Chronic | | 1 3.0| Interlobular, Inflammation, Chronic | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Acanthosis | | 2 1.5| Hyperkeratosis | | 2 1.5| Inflammation, Necrotizing | | 1 2.0| Ulcer | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 5| 2| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| | DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 0| 9| 3| 3| 3| 3| 1| 4| 3| 4| 3| 5| | | 0| 4| 8| 0| 0| 0| 1| 3| 1| 1| 1| 8| 1| 4| 1| 4| 4| 4| 4| 4| 5| 4| 1| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Ectopic Tissue | | 1 2.0| Inflammation, Chronic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Coronary Artery, Inflammation, | | | Chronic | 3 2 | 2 2.5| Epicardium, Inflammation, Chronic | | 2 1.0| Myocardium, Inflammation, Chronic, | | | Multifocal | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +| 39 | Subcapsular, Hyperplasia | 2 | 4 1.8| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| 39 | Hyperplasia | | 1 2.0| Infarct | 3| 1 3.0| Zona Glomerulosa, Cytoplasmic | | | Alteration | 2 | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +| 38 | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + + + + + + + + + + + + + + + + + I + + + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | | 3 | Abscess | | 2 3.5| Duct, Dilatation | | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Serosa, Inflammation, Necrotizing | 1 | 1 1.0| __________________________________________________________________________|____________| Seminal Vesicle | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 66 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 5| 2| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| | DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 0| 9| 3| 3| 3| 3| 1| 4| 3| 4| 3| 5| | | 0| 4| 8| 0| 0| 0| 1| 3| 1| 1| 1| 8| 1| 4| 1| 4| 4| 4| 4| 4| 5| 4| 1| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Tunic, Inflammation, Necrotizing | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + I + M + +| 48 | Deep Cervical, Sinus, Ectasia | 3 | 1 3.0| Mandibular, Abscess | 3 | 1 3.0| Mandibular, Bacterium | X | 1 | Mediastinal, Hematopoietic Cell | | | Proliferation | 3 | 1 3.0| Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0| Sinus, Mandibular, Ectasia | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| 32 | Hematopoietic Cell Proliferation | 3 2 3 2 3| 13 2.3| Hyperplasia, Lymphoid | | 1 2.0| Hyperplasia, Plasma Cell | 3 | 1 3.0| Inflammation, Granulomatous | | 1 2.0| Sinus, Ectasia | 3 4 1 2 2 4 4 | 9 2.4| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Lymphoid | | 1 3.0| Hematopoietic Cell Proliferation | 2 2 2 3 1 3 3 | 10 2.4| Hyperplasia, Lymphoid | 2 2 | 3 2.0| Infiltration Cellular, Plasma Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + M + + + + + M + + M M M M M + I + + M + + + M +| 29 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1| 24 1.0| Parasite Metazoan | X X X X X X X X X X X X| 23 | Subcutaneous Tissue, Fat, Necrosis | 3 1 | 2 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Tarsal, Hyperostosis | X 2 | 5 2.0| __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 67 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 5| 2| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| | DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 8| 3| 3| 3| 4| 3| 0| 9| 3| 3| 3| 3| 1| 4| 3| 4| 3| 5| | | 0| 4| 8| 0| 0| 0| 1| 3| 1| 1| 1| 8| 1| 4| 1| 4| 4| 4| 4| 4| 5| 4| 1| 4| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | 2 2 2 | 3 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 | 2 2.0| Artery, Thrombosis | | 1 | Bronchus, Foreign Body | 2 | 1 2.0| Interstitium, Inflammation, Chronic | 1 | 2 1.0| Mediastinum, Inflammation, Chronic | | | Active | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 3 | Inflammation, Necrotizing | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 1 | 1 1.0| Nephropathy, Chronic | 1 1 2 2 | 9 1.4| Artery, Inflammation, Subacute | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2| 1 2.0| Parasite Metazoan | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 68 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 7| 2| 2| 2| 9| 2| 6| 2| 7| 2| 2| 2| 1| 8| 2| 5| 2| 2| 5| 2| 2| 2| 1| | 7| 7| 0| 7| 7| 7| 5| 7| 5| 8| 8| 8| 8| 8| 7| 5| 8| 5| 8| 9| 2| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + M A| Epithelium, Hyperplasia | | Epithelium, Inclusion Body | | Intracytoplasmic | | Lumen, Crystals | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Jejunum | M + + + + + + + A + + + + + A + + A + + + + + + +| Ulcer | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Basophilic Focus | X X X X | Clear Cell Focus | X 2 X X X X | Cyst | X | Cytologic Alterations | 2 1 2 2 2 3 2 1 2 2 | Cytomegaly | 2 1 2 2 2 1 1 1 2 2 2 1 2 1 1 2 1 | Eosinophilic Focus | 2 4 2 1 3 3 2 X 4 4 2| Fatty Change | 1 | Hematopoietic Cell Proliferation | 1 | Necrosis, Coagulative | 2 2 2 3| Thrombosis | X X X| Hepatocyte, Necrosis | 1 1 1 | __________________________________________________________________________| Mesentery | + +| Inflammation, Chronic | 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Interlobular, Inflammation, Chronic | 2| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| Inflammation, Acute | 1 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 7| 2| 2| 2| 9| 2| 6| 2| 7| 2| 2| 2| 1| 8| 2| 5| 2| 2| 5| 2| 2| 2| 1| | 7| 7| 0| 7| 7| 7| 5| 7| 5| 8| 8| 8| 8| 8| 7| 5| 8| 5| 8| 9| 2| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Tooth | + + + + | Gingiva, Inflammation, Chronic Active| 4 2 | Pulp, Inflammation, Chronic Active | 3 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + M + + + + + +| Coronary Artery, Inflammation, | | Chronic | 1 | Myocardium, Inflammation, Chronic, | | Multifocal | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | 1 2 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Hyperplasia | 1 2 | Hypertrophy | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + M + M M + M + + + + + + + + M + + + + M + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | __________________________________________________________________________| Preputial Gland | + | Duct, Dilatation | 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Seminiferous Tubule, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 7| 2| 2| 2| 9| 2| 6| 2| 7| 2| 2| 2| 1| 8| 2| 5| 2| 2| 5| 2| 2| 2| 1| | 7| 7| 0| 7| 7| 7| 5| 7| 5| 8| 8| 8| 8| 8| 7| 5| 8| 5| 8| 9| 2| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Deep Cervical, Hyperplasia, Plasma | | Cell | | Mandibular, Abscess | 4 | Mandibular, Hyperplasia, Lymphoid | | Mandibular, Infiltration Cellular, | | Histiocyte | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hematopoietic Cell Proliferation | 2 2 3 1 3 2| Infiltration Cellular, Histiocyte | 3 4 | Inflammation, Granulomatous | | Sinus, Ectasia | 3 2 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Hematopoietic Cell Proliferation | 2 3 2 2| Hyperplasia, Lymphoid | | Infiltration Cellular, Plasma Cell | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M M M M + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation, Chronic | | Inflammation, Necrotizing | 1 4 | Parasite Metazoan | X X X X X X X X X X X X X X X X X X X X | Ulcer | 2 | Dermis, Metaplasia, Osseous | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Hyperostosis | X 2| __________________________________________________________________________| Skeletal Muscle | + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 1 | Bacterium | X | Alveolus, Infiltration Cellular, | | Histiocyte | 2 | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 7| 2| 2| 2| 9| 2| 6| 2| 7| 2| 2| 2| 1| 8| 2| 5| 2| 2| 5| 2| 2| 2| 1| | 7| 7| 0| 7| 7| 7| 5| 7| 5| 8| 8| 8| 8| 8| 7| 5| 8| 5| 8| 9| 2| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Interstitium, Inflammation, Chronic | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Anterior Chamber, Inflammation, | | Suppurative | 3 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Cyst | X 2 | Hydronephrosis | | Infarct | 1 | Nephropathy, Chronic | 1 3 1 2 | Glomerulus, Amyloid Deposition | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 1| 2| 8| 0| 3| 3| | | 9| 0| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 4| 4| 6| 4| 4| 4| 2| 1| 4| 1| 7| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + M + + + + + + + + M + + + + A + + A + +| 43 | Epithelium, Hyperplasia | 4 | 1 4.0| Epithelium, Inclusion Body | | | Intracytoplasmic | 3 4 | 2 3.5| Lumen, Crystals | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | Parasite Metazoan | | 4 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + M + +| 47 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 45 | Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 | 1 2.0| Basophilic Focus | 3 4 | 6 3.5| Clear Cell Focus | 2 X X 2 2 X X| 13 2.0| Cyst | | 1 | Cytologic Alterations | 1 2 1 2 2 1 2 2 2 2 3 | 21 1.9| Cytomegaly | 1 2 1 2 3 1 2 2 1 3 1 2 2 4 1 2 2 1 1| 36 1.7| Eosinophilic Focus | 3 X 1 3 3 X 4 4 3| 20 2.8| Fatty Change | 1 | 2 1.0| Hematopoietic Cell Proliferation | 2 | 2 1.5| Necrosis, Coagulative | 1 1 2 2 3 | 9 2.0| Thrombosis | X X X | 6 | Hepatocyte, Necrosis | | 3 1.0| __________________________________________________________________________|____________| Mesentery | + | 3 | Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interlobular, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 1| 2| 8| 0| 3| 3| | | 9| 0| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 4| 4| 6| 4| 4| 4| 2| 1| 4| 1| 7| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Acanthosis | 3 | 1 3.0| Hyperkeratosis | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 | Inflammation, Acute | | 1 1.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | | 4 | Gingiva, Inflammation, Chronic Active| | 2 3.0| Pulp, Inflammation, Chronic Active | | 2 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Coronary Artery, Inflammation, | | | Chronic | | 1 1.0| Myocardium, Inflammation, Chronic, | | | Multifocal | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Hyperplasia | 2 | 3 1.7| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 3 | 1 3.0| Hyperplasia | 1 | 3 1.3| Hypertrophy | | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 3 | 2 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + M + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | | 1 | Duct, Dilatation | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 1| 2| 8| 0| 3| 3| | | 9| 0| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 4| 4| 6| 4| 4| 4| 2| 1| 4| 1| 7| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Seminiferous Tubule, Atrophy | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Deep Cervical, Hyperplasia, Plasma | | | Cell | 2 | 1 2.0| Mandibular, Abscess | | 1 4.0| Mandibular, Hyperplasia, Lymphoid | 2 2 | 2 2.0| Mandibular, Infiltration Cellular, | | | Histiocyte | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| 34 | Angiectasis | | 1 2.0| Hematopoietic Cell Proliferation | 2 2 1 1 1 2 | 12 1.8| Infiltration Cellular, Histiocyte | 4 4 | 4 3.8| Inflammation, Granulomatous | 3 | 1 3.0| Sinus, Ectasia | 3 3 3 3 3 3 3 3| 18 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 | 1 2.0| Hematopoietic Cell Proliferation | 1 1 2 4 2 | 9 2.1| Hyperplasia, Lymphoid | 3 1 | 2 2.0| Infiltration Cellular, Plasma Cell | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + M + M M + + + + + + M + +| 40 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | | 1 4.0| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.0| Inflammation, Chronic | 1 | 1 1.0| Inflammation, Necrotizing | | 2 2.5| Parasite Metazoan | X X X X X X X X X X X X X X X| 35 | Ulcer | | 1 2.0| Dermis, Metaplasia, Osseous | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 75 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 6| 7| 6| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 1| 2| 8| 0| 3| 3| | | 9| 0| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 4| 4| 6| 4| 4| 4| 2| 1| 4| 1| 7| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Tarsal, Hyperostosis | 2 X X | 5 2.0| __________________________________________________________________________|____________| Skeletal Muscle | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | | 1 1.0| Bacterium | | 1 | Alveolus, Infiltration Cellular, | | | Histiocyte | 2 | 2 2.0| Interstitium, Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Anterior Chamber, Inflammation, | | | Suppurative | | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | + + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 4 | 1 4.0| Cyst | 2 2 1 2 | 6 1.8| Hydronephrosis | 4 | 1 4.0| Infarct | | 1 1.0| Nephropathy, Chronic | 2 1 1 2 | 8 1.6| Glomerulus, Amyloid Deposition | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 76 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 7| 0| 2| 2| 2| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 8| 9| 5| 9| 9| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + M + + + + + + + A M + + + + + +| Epithelium, Inclusion Body | | Intracytoplasmic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A A + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + M + + + + + + + + + + M + + + A + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A A + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| Ulcer | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| Abscess | 3 | Bacterium | X | Basophilic Focus | | Clear Cell Focus | X X 1 X | Cytomegaly | 2 2 2 1 1 2 1 1 2 2 1 1 2 2 1 2 1 2 1 1 1 1 1| Eosinophilic Focus | 2 2 3 3 | Fatty Change | 1| Necrosis, Coagulative | 1 1 2 2 | Thrombosis | X | Bile Duct, Dilatation | | Hepatocyte, Necrosis | 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Duct, Fibrosis | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + A A + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + A A + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A A + + + + + +| Mucosa, Hyperplasia | | __________________________________________________________________________| Tooth | + + + | Gingiva, Inflammation, Chronic Active| 3 2 | Pulp, Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Myocardium, Inflammation, Chronic, | | Multifocal | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 7| 0| 2| 2| 2| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 8| 9| 5| 9| 9| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + A + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Seminiferous Tubule, Atrophy | 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | Hematopoietic Cell Proliferation | 1 2 1 2 2 2 | Hyperplasia, Lymphoid | 2 2 | Infiltration Cellular, Histiocyte | 2 2 | Artery, Thrombosis | X | Sinus, Ectasia | 1 2 2 4 2 3 2 2 1 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia, Lymphoid | 2 4| __________________________________________________________________________| Thymus | + + + + + + + M M + + + + + + M + M M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + | Duct, Ectasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 | Parasite Metazoan | X X X X X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 7| 0| 2| 2| 2| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 8| 9| 5| 9| 9| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 2| 3| 4| 5| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Coccygeal, Fracture Healed | | Femur, Osteopetrosis | | Tarsal, Hyperostosis | X X X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Bacterium | | Inflammation, Acute | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 1 | Alveolus, Infiltration Cellular, | | Histiocyte | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Synechia | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2| Infiltration Cellular, Lymphocyte | 3 | Nephropathy, Chronic | 1 1 1 2 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | | 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 7| 1| 0| 4| 4| 4| 4| 4| 4| 4| 4| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A | 3 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 1-1 | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + | 45 | Epithelium, Inclusion Body | | | Intracytoplasmic | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + | 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + A + + + + + + + + + | 44 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + | 46 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + | 44 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + | 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + | 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + | 45 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + | 47 | Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 48 | Abscess | | 1 3.0| Bacterium | | 1 | Basophilic Focus | X | 1 | Clear Cell Focus | X 3 X X X X X X X X X | 15 2.0| Cytomegaly | 2 3 2 1 2 3 2 2 2 1 2 2 1 1 1 1 1 1 1 2 1 | 44 1.5| Eosinophilic Focus | 3 3 4 2 | 8 2.8| Fatty Change | 1 1 1 | 4 1.0| Necrosis, Coagulative | 1 | 5 1.4| Thrombosis | | 1 | Bile Duct, Dilatation | 2 | 1 2.0| Hepatocyte, Necrosis | 1 1 | 3 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + | 47 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Duct, Fibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | Mucosa, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Tooth | + | 4 | Gingiva, Inflammation, Chronic Active| | 2 2.5| Pulp, Inflammation, Chronic Active | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | | 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 7| 1| 0| 4| 4| 4| 4| 4| 4| 4| 4| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A | 3 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 1-1 | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Myocardium, Inflammation, Chronic, | | | Multifocal | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | Hyperplasia | 1 | 2 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + M | 46 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + A + + M + + + + + + | 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + M + + + + + + + + M + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Seminal Vesicle | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Seminiferous Tubule, Atrophy | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + A + + + + + + + + + | 48 | Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 34 | Hematopoietic Cell Proliferation | 3 1 1 2 1 1 1 1 | 14 1.5| Hyperplasia, Lymphoid | 4 2 2 2 3 3 | 8 2.5| Infiltration Cellular, Histiocyte | 2 3 3 1 | 6 2.2| Artery, Thrombosis | | 1 | Sinus, Ectasia | 1 2 1 2 1 1 | 16 1.8| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + A + + + + + + + + + | 47 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia, Lymphoid | 2 1 3 3 2 | 7 2.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | | 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 7| 1| 0| 4| 4| 4| 4| 4| 4| 4| 4| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A | 3 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 1-1 | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + + M M + + + + + + + + M | 40 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 2 | Duct, Ectasia | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Acanthosis | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 | 32 1.1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 29 1.0| Parasite Metazoan | X X X X X X X X X X X X X | 29 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Coccygeal, Fracture Healed | X | 1 | Femur, Osteopetrosis | 2 | 1 2.0| Tarsal, Hyperostosis | X X X X X X | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Bacterium | X | 1 | Inflammation, Acute | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Alveolar Epithelium, Hyperplasia | | 1 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 2 | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Synechia | 4 | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | + + + | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Cyst | 2 | 3 2.0| Infiltration Cellular, Lymphocyte | | 1 3.0| Nephropathy, Chronic | 1 1 | 8 1.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | | DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | | 0| 2| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 7| 1| 0| 4| 4| 4| 4| 4| 4| 4| 4| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A | 3 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L | 1-1 | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 48 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 0| 6| 2| 2| 2| 2| 1| 2| 2| | 7| 7| 7| 0| 7| 3| 7| 0| 7| 8| 8| 8| 4| 8| 8| 8| 4| 1| 8| 9| 9| 9| 6| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + M + + + M + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | Ulcer | 2 4 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + M + + + + + + + + A + + + + + + + +| Parasite Metazoan | | Ulcer | 1 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +| Hyperplasia, Lymphoid | | Ulcer | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X X X X 2 X 2 | Cyst | X | Cytomegaly | 3 3 3 2 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Eosinophilic Focus | 3 X 4 2 3 3 3 3 2 3 3 | Fatty Change | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis, Coagulative | 3 2 1 1 2 1 2 1| Thrombosis | X X | Hepatocyte, Necrosis | 1 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + + + | Pulp, Inflammation, Chronic Active | 3 3 | Pulp, Inflammation, Suppurative | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Coronary Artery, Inflammation, | | Chronic | 1 | Myocardium, Inflammation, Chronic, | | Multifocal | | _____________________________________________________________________________________________________________________| Page 84 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 0| 6| 2| 2| 2| 2| 1| 2| 2| | 7| 7| 7| 0| 7| 3| 7| 0| 7| 8| 8| 8| 4| 8| 8| 8| 4| 1| 8| 9| 9| 9| 6| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Myocardium, Mineralization, | | Multifocal | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + M M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + | Abscess | 3 | __________________________________________________________________________| Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Seminal Vesicle | + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + M + + + + + + + + + + + + + + + + +| Mandibular, Abscess | | Mandibular, Bacterium | | Mandibular, Hyperplasia, Lymphoid | | Mandibular, Hyperplasia, Plasma Cell | 3 | Mandibular, Infiltration Cellular, | | Histiocyte | | Pancreatic, Hyperplasia, Lymphoid | 4 | Renal, Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 1 1 2 2 1 1 1 | Hyperplasia, Lymphoid | 4 4 4 1| Infiltration Cellular, Histiocyte | 2 2 2 2 2 | Sinus, Ectasia | 2 4 3 1 3 2 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 | Depletion Lymphoid | 2 | _____________________________________________________________________________________________________________________| Page 85 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 8| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 0| 6| 2| 2| 2| 2| 1| 2| 2| | 7| 7| 7| 0| 7| 3| 7| 0| 7| 8| 8| 8| 4| 8| 8| 8| 4| 1| 8| 9| 9| 9| 6| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 1 1 2 2 | Hyperplasia, Lymphoid | 2 4 | __________________________________________________________________________| Thymus | M + + M + + + + M + + + + + + + M + M + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| Cyst Epithelial Inclusion | X | Hyperkeratosis | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| Parasite Metazoan | X X X X X X X X X X X X X X X X X X| Sebaceous Gland, Ectasia | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | | Alveolus, Infiltration Cellular, | | Histiocyte | 1 | Artery, Thrombosis | X | Interstitium, Inflammation, Chronic | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Hyperplasia, Nodular | 1 | Duct, Dilatation | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Bacterium | | Cyst | 2 | Inflammation, Acute | | Nephropathy, Chronic | 2 1 1 3 3 2 1 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 86 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 0| 3| 3| 3| 3| 8| 3| 0| 0| 3| 6| 3| 3| 3| 2| 3| 3| 3| 6| 0| 3| 3| 3| 3| | | 9| 7| 0| 0| 0| 0| 7| 0| 2| 5| 0| 7| 0| 1| 1| 3| 4| 4| 4| 0| 6| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + M + + + M + + + + + M + + + + + + M M + + + +| 43 | __________________________________________________________________________|____________| Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 1 | Ulcer | | 2 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X| 4 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + M + + + + A + + + + + + + + + + + + + + + + + +| 46 | Parasite Metazoan | X X | 2 | Ulcer | 4 | 2 2.5| __________________________________________________________________________|____________| Intestine Small, Jejunum | + M + + + + A + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia, Lymphoid | 4 | 1 4.0| Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Basophilic Focus | 3 X X| 3 3.0| Clear Cell Focus | 3 | 8 2.3| Cyst | | 1 | Cytomegaly | 3 3 3 3 3 3 3 3 3 2 3 3 3 3 2 3 3 3 3 3 3 3 3 3| 49 2.9| Eosinophilic Focus | 3 3 3 X 3 | 16 2.9| Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0| Necrosis, Coagulative | 2 1 2 2 2 3 1 2 2| 17 1.8| Thrombosis | X | 3 | Hepatocyte, Necrosis | 1 1 | 4 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Artery, Inflammation, Chronic | 1 3 | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tooth | | 3 | Pulp, Inflammation, Chronic Active | | 2 3.0| Pulp, Inflammation, Suppurative | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 87 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 0| 3| 3| 3| 3| 8| 3| 0| 0| 3| 6| 3| 3| 3| 2| 3| 3| 3| 6| 0| 3| 3| 3| 3| | | 9| 7| 0| 0| 0| 0| 7| 0| 2| 5| 0| 7| 0| 1| 1| 3| 4| 4| 4| 0| 6| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Coronary Artery, Inflammation, | | | Chronic | | 1 1.0| Myocardium, Inflammation, Chronic, | | | Multifocal | 1 1 | 2 1.0| Myocardium, Mineralization, | | | Multifocal | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Subcapsular, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + A + + M + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + + + + + + + + + + + M + + + + + +| 46 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | | 1 | Abscess | | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + | 2 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | Mandibular, Abscess | 3 | 1 3.0| Mandibular, Bacterium | X | 1 | Mandibular, Hyperplasia, Lymphoid | 2| 1 2.0| Mandibular, Hyperplasia, Plasma Cell | | 1 3.0| Mandibular, Infiltration Cellular, | | | Histiocyte | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 88 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 0| 3| 3| 3| 3| 8| 3| 0| 0| 3| 6| 3| 3| 3| 2| 3| 3| 3| 6| 0| 3| 3| 3| 3| | | 9| 7| 0| 0| 0| 0| 7| 0| 2| 5| 0| 7| 0| 1| 1| 3| 4| 4| 4| 0| 6| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Hyperplasia, Lymphoid | | 1 4.0| Renal, Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +| 37 | Hematopoietic Cell Proliferation | 1 1 2 1 2 1 1 1 1 1| 20 1.4| Hyperplasia, Lymphoid | 2 3 2 2 | 8 2.8| Infiltration Cellular, Histiocyte | 1 2 2| 8 1.9| Sinus, Ectasia | 2 1 2 3 3 2 2 | 14 2.2| __________________________________________________________________________|____________| Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Amyloid Deposition | | 1 2.0| Depletion Lymphoid | 2 | 2 2.0| Hematopoietic Cell Proliferation | 2 1 2 1 | 8 1.5| Hyperplasia, Lymphoid | 2 2 3 | 5 2.6| __________________________________________________________________________|____________| Thymus | + + M + + + M + M + + M M + + + + + + + M + + + M| 37 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.1| Cyst Epithelial Inclusion | | 1 | Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.0| Parasite Metazoan | X X X X X X X X X X X X X X X X X X| 36 | Sebaceous Gland, Ectasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | 1 | 1 1.0| Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 1.0| Artery, Thrombosis | | 1 | Interstitium, Inflammation, Chronic | 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 89 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 0| 3| 3| 3| 3| 8| 3| 0| 0| 3| 6| 3| 3| 3| 2| 3| 3| 3| 6| 0| 3| 3| 3| 3| | | 9| 7| 0| 0| 0| 0| 7| 0| 2| 5| 0| 7| 0| 1| 1| 3| 4| 4| 4| 0| 6| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | Hyperplasia, Nodular | | 1 1.0| Duct, Dilatation | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bacterium | X | 1 | Cyst | | 1 2.0| Inflammation, Acute | 3 | 1 3.0| Nephropathy, Chronic | 3 3 | 10 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 90 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 1| 4| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 2| 2| 1| 2| 2| 9| 2| 2| 2| 1| 5| 2| 3| 2| 2| 2| 8| 1| 2| 2| 2| 2| 2| 7| 2| | 7| 7| 6| 7| 7| 2| 7| 7| 8| 9| 3| 8| 1| 8| 8| 2| 3| 5| 8| 8| 9| 9| 0| 5| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + M M + M + + + + + + + + + A + A + + + + + M +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + M + + + + + + + M + + + + + + + + + + +| Parasite Metazoan | X X X| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + M + + + + + + + + + + + A + + + + + + +| Parasite Metazoan | X | Ulcer | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + A + + + + + + +| Basophilic Focus | X 3 | Clear Cell Focus | X X X X X 2 | Cytomegaly | 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3| Eosinophilic Focus | 3 | Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis, Coagulative | 1 3 1 2 2 1 1 | Thrombosis | X | Hepatocyte, Necrosis | | Oval Cell, Hyperplasia | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +| Acinus, Atrophy | | Duct, Ectasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 3 | Bacterium | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| Inflammation, Chronic | 1 | Ulcer | 2 | __________________________________________________________________________| Tooth | + + | Gingiva, Inflammation, Chronic Active| | Pulp, Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Coronary Artery, Inflammation, | | Chronic | 1 | _____________________________________________________________________________________________________________________| Page 91 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 1| 4| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 2| 2| 1| 2| 2| 9| 2| 2| 2| 1| 5| 2| 3| 2| 2| 2| 8| 1| 2| 2| 2| 2| 2| 7| 2| | 7| 7| 6| 7| 7| 2| 7| 7| 8| 9| 3| 8| 1| 8| 8| 2| 3| 5| 8| 8| 9| 9| 0| 5| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Myocardium, Inflammation, Chronic, | | Multifocal | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + M + A + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + I + + + + + + + + + + + M + + + M + + +| Pars Distalis, Hyperplasia, Nodular | 1 1 | __________________________________________________________________________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Follicle, Hyperplasia, Nodular | 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + M + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 3 | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Preputial Gland | + | Abscess | 3 | __________________________________________________________________________| Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Inflammation, Suppurative | 2 | __________________________________________________________________________| Testes | + + + + + M + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Hyperplasia, Plasma Cell | 3 | Mandibular, Hyperplasia, Plasma Cell | 2 | Pancreatic, Hematopoietic Cell | | Proliferation | 2| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + +| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 | Hyperplasia, Lymphoid | 2 2 2 4 | Infiltration Cellular, Histiocyte | 2 2 3 2 3 | Sinus, Ectasia | 3 2 3 3 2 2 2 3| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 1| 1| 4| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 2| 2| 1| 2| 2| 9| 2| 2| 2| 1| 5| 2| 3| 2| 2| 2| 8| 1| 2| 2| 2| 2| 2| 7| 2| | 7| 7| 6| 7| 7| 2| 7| 7| 8| 9| 3| 8| 1| 8| 8| 2| 3| 5| 8| 8| 9| 9| 0| 5| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 2 1 1 2 1| Hyperplasia, Lymphoid | 3 2 | __________________________________________________________________________| Thymus | + M M + + + + + M M + M + M M + + M + M + + M + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Parasite Metazoan | X X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Hyperostosis | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 | Artery, Thrombosis | | Interstitium, Inflammation, Chronic | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + M + + + + + + + + + + + + + + + + + + +| Cyst | | Infarct | | Metaplasia, Osseous | | Nephropathy, Chronic | 2 2 1 2 1 3 2 2 | Glomerulus, Inflammation, | | Membranoproliferative | 1 | Glomerulus, Nephropathy, Chronic | | __________________________________________________________________________| Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 93 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 2| 2| 0| 2| 3| 4| 3| 3| 3| 3| 3| 8| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 8| 7| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 5| 1| 1| 1| 4| 4| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | M + M A + + + + + + + + M + + + M + + + + + + + +| 39 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X X | 9 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X X| 5 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | | 1 | Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Basophilic Focus | X X X 3 2 | 7 2.7| Clear Cell Focus | X X | 8 2.0| Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 48 3.0| Eosinophilic Focus | 3 3 3 | 4 3.0| Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 43 1.0| Necrosis, Coagulative | 1 2 1 1 1 1 1 3 1 | 16 1.4| Thrombosis | | 1 | Hepatocyte, Necrosis | 1 | 1 1.0| Oval Cell, Hyperplasia | 4 | 2 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 3 | 1 3.0| Duct, Ectasia | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | | 1 3.0| Bacterium | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic | | 1 1.0| Ulcer | | 1 2.0| __________________________________________________________________________|____________| Tooth | + + + + | 6 | Gingiva, Inflammation, Chronic Active| 2 | 1 2.0| Pulp, Inflammation, Chronic Active | 3 3 2 | 4 2.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 94 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 2| 2| 0| 2| 3| 4| 3| 3| 3| 3| 3| 8| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 8| 7| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 5| 1| 1| 1| 4| 4| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Coronary Artery, Inflammation, | | | Chronic | | 1 1.0| Myocardium, Inflammation, Chronic, | | | Multifocal | 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + + + + + + + M + + + + + + + + + M| 44 | Pars Distalis, Hyperplasia, Nodular | | 2 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Follicle, Hyperplasia, Nodular | | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Granuloma Sperm | | 1 3.0| Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Preputial Gland | + | 2 | Abscess | 3 | 2 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 3.0| Inflammation, Suppurative | 3 2 | 3 2.3| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + M + + M + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 95 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 2| 2| 0| 2| 3| 4| 3| 3| 3| 3| 3| 8| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 8| 7| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 5| 1| 1| 1| 4| 4| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lumbar, Hyperplasia, Plasma Cell | | 1 3.0| Mandibular, Hyperplasia, Plasma Cell | | 1 2.0| Pancreatic, Hematopoietic Cell | | | Proliferation | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +| 35 | Hematopoietic Cell Proliferation | 1 2 1 1 1 1 1| 13 1.1| Hyperplasia, Lymphoid | 2 | 5 2.4| Infiltration Cellular, Histiocyte | 3 2 3 3| 9 2.6| Sinus, Ectasia | 2 3 2 3 1 1 3 3 1 3 3 | 19 2.4| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 2 2 | 8 1.6| Hyperplasia, Lymphoid | | 2 2.5| __________________________________________________________________________|____________| Thymus | M + + M M M M + M + + + M M M M + + + + + + + + +| 29 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 38 1.0| Parasite Metazoan | X X X X X X X X X X X X X X X X X X X| 36 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Tarsal, Hyperostosis | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | 3 | 2 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 1.0| Artery, Thrombosis | X | 1 | Interstitium, Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 96 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 2| 2| 0| 2| 3| 4| 3| 3| 3| 3| 3| 8| 3| 3| 7| 1| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 8| 7| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 5| 1| 1| 1| 4| 4| 4| 4| 4| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 2 2 3 2 | 4 2.3| Infarct | 2 | 1 2.0| Metaplasia, Osseous | 1 1 | 2 1.0| Nephropathy, Chronic | 3 2 1| 11 1.9| Glomerulus, Inflammation, | | | Membranoproliferative | | 1 1.0| Glomerulus, Nephropathy, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 97 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 7| 5| 7| 3| 5| 7| 6| 7| 7| 6| 1| 7| 7| DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 9| 5| 2| 7| 2| 2| 5| 2| 9| 5| 2| 5| 2| 2| 6| 3| 2| 2| | 1| 7| 1| 7| 7| 1| 7| 4| 3| 7| 0| 7| 8| 9| 8| 1| 9| 8| 1| 5| 8| 2| 8| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + + + + + + + + + + + + + + + + M M + + M| __________________________________________________________________________| Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X X X| __________________________________________________________________________| Intestine Large, Rectum | A + M + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Intestine Small, Ileum | A + M + + + + + + + M + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 2 X X X | Clear Cell Focus | 3 X | Cytomegaly | 2 3 2 2 3 2 3 2 3 3 2 3 3 2 3 3 2 3 3 2 2 3 3| Fatty Change | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1| Granuloma | | Necrosis, Coagulative | 1 1 2 1 2 1 2 3 1 2| Parasite Metazoan | | Thrombosis | X| Bile Duct, Hyperplasia | 1 1| Hepatocyte, Necrosis | 1 1 1 | Oval Cell, Proliferation | 1 | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic | 2 | __________________________________________________________________________| Pancreas | M + + + + + + + + + + + + + + + + + + + + A + + +| Acinus, Atrophy | 2 | Artery, Inflammation, Chronic | 4 | Duct, Ectasia | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | A + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + M + + +| Cyst Epithelial Inclusion | X | Inflammation, Chronic | 3 | __________________________________________________________________________| Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + M + + +| Mucosa, Mineralization | 1 | __________________________________________________________________________| Tooth | | Pulp, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 98 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 7| 5| 7| 3| 5| 7| 6| 7| 7| 6| 1| 7| 7| DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 9| 5| 2| 7| 2| 2| 5| 2| 9| 5| 2| 5| 2| 2| 6| 3| 2| 2| | 1| 7| 1| 7| 7| 1| 7| 4| 3| 7| 0| 7| 8| 9| 8| 1| 9| 8| 1| 5| 8| 2| 8| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Tissue | | Myocardium, Inflammation, Chronic, | | Multifocal | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | M + + + + + + M + + + + + M + + + + + + + A + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | M M + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Hyperplasia, Nodular | 1 1 1 1 2 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Seminiferous Tubule, Atrophy | | Seminiferous Tubule, Hypospermia | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | A + + + + + + + + + + + + + + + + + + + + A + + +| Mediastinal, Sinus, Ectasia | | Sinus, Mandibular, Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 1 2 2 1 | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | | Infiltration Cellular, Histiocyte | | Sinus, Ectasia | 3 2 2 2 2 3 2 2 2 3 4| __________________________________________________________________________| Spleen | A + + + + + + + + + + + + + + + + + + + + A + + +| Fibrosis | | Hematopoietic Cell Proliferation | 2 2 1 2 1| __________________________________________________________________________| Thymus | + + + + + + + M M + M + + M + + + + M M + + + M +| _____________________________________________________________________________________________________________________| Page 99 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 5| 7| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 7| 5| 7| 3| 5| 7| 6| 7| 7| 6| 1| 7| 7| DAY ON TEST | 4| 2| 7| 2| 2| 2| 2| 9| 5| 2| 7| 2| 2| 5| 2| 9| 5| 2| 5| 2| 2| 6| 3| 2| 2| | 1| 7| 1| 7| 7| 1| 7| 4| 3| 7| 0| 7| 8| 9| 8| 1| 9| 8| 1| 5| 8| 2| 8| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + | __________________________________________________________________________| Skin | A + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation, Chronic | | Parasite Metazoan | X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Hyperostosis | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypothalamus, Compression | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 | Alveolus, Inflammation, Acute | | Artery, Thrombosis | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | A + + + + + + + + + + + + + + + + + + + + A + + +| Infarct | | Metaplasia, Osseous | 1 | Nephropathy, Chronic | 2 | Glomerulus, Inflammation, | | Membranoproliferative | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 100 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| | DAY ON TEST | 2| 6| 2| 0| 1| 3| 4| 3| 9| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| | | 9| 2| 9| 2| 6| 0| 8| 0| 1| 0| 0| 0| 0| 1| 2| 1| 1| 1| 4| 8| 4| 4| 4| 4| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | __________________________________________________________________________|____________| Gallbladder | M M M + M + + M M + M + + M M + + + + M + + + + +| 36 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X X X X X X | 14 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + M + + + + + + A + + + + + + + + + + + M + + + A| 43 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + A + + + + + + + + + + + + + + + +| 47 | Ulcer | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X 3 3 | 8 2.7| Clear Cell Focus | X X X | 5 3.0| Cytomegaly | 2 3 3 3 3 3 3 2 3 2 3 2 3 3 3 3 2 3 3 3 3 3 2 3 2| 48 2.6| Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| 40 1.1| Granuloma | 2 | 1 2.0| Necrosis, Coagulative | 1 2 3 3 1 1 1 1 2 3 3 2 3| 23 1.8| Parasite Metazoan | X | 1 | Thrombosis | X X X X X | 6 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 8 1.0| Hepatocyte, Necrosis | 1 | 4 1.0| Oval Cell, Proliferation | | 1 1.0| __________________________________________________________________________|____________| Mesentery | + | 2 | Inflammation, Chronic | 2 | 2 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Acinus, Atrophy | 1 | 2 1.5| Artery, Inflammation, Chronic | 3 | 2 3.5| Duct, Ectasia | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Cyst Epithelial Inclusion | | 1 | Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 101 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| | DAY ON TEST | 2| 6| 2| 0| 1| 3| 4| 3| 9| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| | | 9| 2| 9| 2| 6| 0| 8| 0| 1| 0| 0| 0| 0| 1| 2| 1| 1| 1| 4| 8| 4| 4| 4| 4| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mucosa, Mineralization | | 1 1.0| __________________________________________________________________________|____________| Tooth | + | 1 | Pulp, Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectopic Tissue | X | 1 | Myocardium, Inflammation, Chronic, | | | Multifocal | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + + + M| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + M + + + + + + + + M + + + + M + M + + M M| 41 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Follicle, Hyperplasia, Nodular | 1 1 1 2 1 4 1 2 | 16 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 2| 2 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 4| 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Seminiferous Tubule, Atrophy | 4| 1 4.0| Seminiferous Tubule, Hypospermia | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + M + + + + + + + + + + + + + + + M| 46 | Mediastinal, Sinus, Ectasia | 2 | 1 2.0| Sinus, Mandibular, Ectasia | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 102 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| | DAY ON TEST | 2| 6| 2| 0| 1| 3| 4| 3| 9| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| | | 9| 2| 9| 2| 6| 0| 8| 0| 1| 0| 0| 0| 0| 1| 2| 1| 1| 1| 4| 8| 4| 4| 4| 4| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 31 | Hematopoietic Cell Proliferation | 1 1 2 1 1 1 2 2 2 | 14 1.4| Hyperplasia, Lymphoid | 2 2 | 2 2.0| Hyperplasia, Plasma Cell | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 1 2 | 2 1.5| Sinus, Ectasia | 2 2 3 1 3 3 3 2 4 3 2 4 4 | 24 2.6| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 1 1 2 2 2| 11 1.6| __________________________________________________________________________|____________| Thymus | M + M M M M M + M + M M M + + + M M M M M M + M M| 25 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0| Inflammation, Chronic | 1 | 1 1.0| Parasite Metazoan | X X X X X X X X X X X X X | 29 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Tarsal, Hyperostosis | X | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Hypothalamus, Compression | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | 2 | 2 1.5| Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 1.0| Alveolus, Inflammation, Acute | 3 2 | 2 2.5| Artery, Thrombosis | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 103 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| | DAY ON TEST | 2| 6| 2| 0| 1| 3| 4| 3| 9| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 8| 3| 3| 3| 3| | | 9| 2| 9| 2| 6| 0| 8| 0| 1| 0| 0| 0| 0| 1| 2| 1| 1| 1| 4| 8| 4| 4| 4| 4| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Infarct | 2| 1 2.0| Metaplasia, Osseous | 1 1 | 3 1.0| Nephropathy, Chronic | 3 2 2 1 | 5 2.0| Glomerulus, Inflammation, | | | Membranoproliferative | 1 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 4| 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 104 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 6| 5| 7| 6| 7| 6| 6| 7| 4| 6| 5| 6| 6| 5| 4| 6| 6| 6| 4| 6| 5| 6| 4| 5| 6| DAY ON TEST | 3| 1| 0| 1| 0| 5| 6| 0| 7| 4| 1| 3| 9| 9| 7| 9| 8| 4| 0| 8| 7| 5| 5| 7| 4| | 6| 3| 0| 3| 3| 0| 2| 4| 7| 9| 0| 6| 4| 9| 5| 9| 8| 1| 4| 2| 3| 4| 0| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + A + M + + M + + + M + + + + M + + + + + + +| Hemorrhage | 3 | Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + M + + + + + + A + + + + + + +| Cyst | X | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X X X X X X X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Small, Ileum | M + + + + + + + + M + + A M + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Jejunum | + + + M + + + + + A + + M + + + + M + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | | Cytomegaly | 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Eosinophilic Focus | 2 X 2 X 4 | Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| Hematopoietic Cell Proliferation | 2 | Necrosis, Coagulative | 1 2 1 2 1 1 2 3 1 1 2 1 1 2| Thrombosis | X X X X X X| Bile Duct, Hyperplasia | 1 2 1 2 1 1 3 1 2 1 1 3 1 1 2 2 1 1 1 2| Hepatocyte, Necrosis | 1 | Vein, Inflammation, Subacute | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Infarct | 4 3| Artery, Inflammation, Chronic | 2 3 2 2 | Duct, Ectasia | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Bacterium | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | _____________________________________________________________________________________________________________________| Page 105 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 6| 5| 7| 6| 7| 6| 6| 7| 4| 6| 5| 6| 6| 5| 4| 6| 6| 6| 4| 6| 5| 6| 4| 5| 6| DAY ON TEST | 3| 1| 0| 1| 0| 5| 6| 0| 7| 4| 1| 3| 9| 9| 7| 9| 8| 4| 0| 8| 7| 5| 5| 7| 4| | 6| 3| 0| 3| 3| 0| 2| 4| 7| 9| 0| 6| 4| 9| 5| 9| 8| 1| 4| 2| 3| 4| 0| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mucosa, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + | Aorta, Inflammation, Chronic Active | 3 | Aorta, Thrombosis | X | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Coronary Artery, Inflammation, | | Chronic | 3 | Myocardium, Inflammation, Chronic, | | Multifocal | 1 1 1 | Valve, Inflammation, Chronic Active | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Hyperplasia | 1 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2| __________________________________________________________________________| Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + M + + M + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| Follicle, Hyperplasia | 4 | Follicle, Hyperplasia, Nodular | 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myeloid Cell, Hyperplasia | 3 2 | __________________________________________________________________________| Lymph Node | + + + + + + + + + M + + + + + + + + + + + + + + M| Mandibular, Abscess | 4 | Mandibular, Fibrosis | 2 | _____________________________________________________________________________________________________________________| Page 106 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 6| 5| 7| 6| 7| 6| 6| 7| 4| 6| 5| 6| 6| 5| 4| 6| 6| 6| 4| 6| 5| 6| 4| 5| 6| DAY ON TEST | 3| 1| 0| 1| 0| 5| 6| 0| 7| 4| 1| 3| 9| 9| 7| 9| 8| 4| 0| 8| 7| 5| 5| 7| 4| | 6| 3| 0| 3| 3| 0| 2| 4| 7| 9| 0| 6| 4| 9| 5| 9| 8| 1| 4| 2| 3| 4| 0| 3| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mandibular, Hyperplasia, Lymphoid | 3 | Mandibular, Infiltration Cellular, | | Histiocyte | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + | Hematopoietic Cell Proliferation | 2 2 2 | Sinus, Ectasia | 1 4 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 3 3 3 2 2 3 3 2 3 3 2 3 3 3 2 2 1 2 2 3 4 3| __________________________________________________________________________| Thymus | + I M + M M M M + M + M M + I M I M + M M + + M M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 | Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 | Parasite Metazoan | X X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolus, Inflammation, Acute | | Bronchus, Metaplasia, Squamous | 1 | Mediastinum, Inflammation, Chronic | | Active | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 3 | Nephropathy, Chronic | 3 2 2 3 2 3 3 3 1 3 2 2 3 3 2 2 3 3 3 3 2 3 2| Fat, Necrosis | | Glomerulus, Inflammation, | | Membranoproliferative | | __________________________________________________________________________| Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Mucosa, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 107 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 4| 5| 5| 5| 6| 5| 6| 5| 4| 6| 4| 6| 6| 5| 6| 6| 5| 6| 6| | DAY ON TEST | 7| 2| 8| 8| 0| 6| 6| 3| 3| 3| 7| 8| 5| 9| 9| 0| 2| 4| 0| 4| 5| 6| 3| 4| 6| | | 6| 5| 0| 2| 6| 4| 1| 1| 1| 1| 9| 7| 9| 1| 6| 9| 0| 1| 9| 0| 5| 5| 0| 8| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + M M + + M +| 47 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + M + + A + + + + + M + + + + + +| 41 | Hemorrhage | | 1 3.0| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + + M + M + + + + + +| 43 | Cyst | | 1 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X X X X X X X| 23 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | M + + + + + + + + + + + M + + + + + + M A + A A A| 39 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Small, Jejunum | A + + + + + + + + + + M + + + + + + + + + + + + M| 43 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 1 | Clear Cell Focus | X | 1 | Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 50 3.0| Eosinophilic Focus | 4 | 6 3.0| Fatty Change | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 50 1.1| Hematopoietic Cell Proliferation | 2 | 2 2.0| Necrosis, Coagulative | 1 1 2 1 1 1 1 3 3 2| 24 1.5| Thrombosis | X X| 8 | Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 2 1 1 2 1 1| 34 1.4| Hepatocyte, Necrosis | 1 | 2 1.0| Vein, Inflammation, Subacute | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | | 1 3.0| Infarct | 4| 3 3.7| Artery, Inflammation, Chronic | 1 3 4 4| 8 2.6| Duct, Ectasia | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + M + + + + + + + + + + + + M M + + M +| 46 | Abscess | | 1 4.0| Bacterium | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 108 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 4| 5| 5| 5| 6| 5| 6| 5| 4| 6| 4| 6| 6| 5| 6| 6| 5| 6| 6| | DAY ON TEST | 7| 2| 8| 8| 0| 6| 6| 3| 3| 3| 7| 8| 5| 9| 9| 0| 2| 4| 0| 4| 5| 6| 3| 4| 6| | | 6| 5| 0| 2| 6| 4| 1| 1| 1| 1| 9| 7| 9| 1| 6| 9| 0| 1| 9| 0| 5| 5| 0| 8| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Mucosa, Hyperplasia | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 3 | Aorta, Inflammation, Chronic Active | 1 | 2 2.0| Aorta, Thrombosis | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 2 | 1 2.0| Coronary Artery, Inflammation, | | | Chronic | | 1 3.0| Myocardium, Inflammation, Chronic, | | | Multifocal | | 3 1.0| Valve, Inflammation, Chronic Active | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Subcapsular, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Infarct | | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 | 3 1.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + A + + + + + + + + + M + + + + + + + +| 47 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + M M + + M +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + + + M M + + + + M + + M M M M M +| 38 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M M + + M +| 46 | Follicle, Hyperplasia | | 1 4.0| Follicle, Hyperplasia, Nodular | 3 1 2 4| 8 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Granuloma Sperm | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 109 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 4| 5| 5| 5| 6| 5| 6| 5| 4| 6| 4| 6| 6| 5| 6| 6| 5| 6| 6| | DAY ON TEST | 7| 2| 8| 8| 0| 6| 6| 3| 3| 3| 7| 8| 5| 9| 9| 0| 2| 4| 0| 4| 5| 6| 3| 4| 6| | | 6| 5| 0| 2| 6| 4| 1| 1| 1| 1| 9| 7| 9| 1| 6| 9| 0| 1| 9| 0| 5| 5| 0| 8| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 | 2 1.5| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myeloid Cell, Hyperplasia | 3 | 3 2.7| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + M + + + + + + + M M + + M +| 44 | Mandibular, Abscess | | 1 4.0| Mandibular, Fibrosis | | 1 2.0| Mandibular, Hyperplasia, Lymphoid | | 1 3.0| Mandibular, Infiltration Cellular, | | | Histiocyte | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + +| 11 | Hematopoietic Cell Proliferation | | 3 2.0| Sinus, Ectasia | 2 2 2 2| 7 2.3| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + I + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 2 2 2 1 1 3 2 2 1 2 2 3 2 2 2 3 3| 41 2.4| __________________________________________________________________________|____________| Thymus | M + + M + + M + + M M + M M M + + M M M + M + M M| 19 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 26 1.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0| Parasite Metazoan | X X X X X X X X X X X X X| 18 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + M M + + + +| 48 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolus, Inflammation, Acute | 2 | 1 2.0| Bronchus, Metaplasia, Squamous | | 1 1.0| Mediastinum, Inflammation, Chronic | | | Active | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + A + + + M + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 110 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 5| 7| 4| 4| 5| 5| 5| 6| 5| 6| 5| 4| 6| 4| 6| 6| 5| 6| 6| 5| 6| 6| | DAY ON TEST | 7| 2| 8| 8| 0| 6| 6| 3| 3| 3| 7| 8| 5| 9| 9| 0| 2| 4| 0| 4| 5| 6| 3| 4| 6| | | 6| 5| 0| 2| 6| 4| 1| 1| 1| 1| 9| 7| 9| 1| 6| 9| 0| 1| 9| 0| 5| 5| 0| 8| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + M M + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | | 1 3.0| Nephropathy, Chronic | 3 1 3 2 2 2 1 1 2 2 2 3 3 2 2 2 2 3 3 3 3 | 44 2.4| Fat, Necrosis | 1 | 1 1.0| Glomerulus, Inflammation, | | | Membranoproliferative | 1 | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A A +| 47 | Inflammation, Chronic Active | | 1 3.0| Mucosa, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 111 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 4| 3| 4| 5| 3| 3| 5| 3| 5| 5| 4| 6| 3| 4| 5| 6| 5| 4| 5| 3| 4| DAY ON TEST | 3| 2| 4| 9| 0| 7| 9| 0| 6| 5| 1| 7| 3| 0| 9| 2| 4| 9| 7| 2| 3| 7| 1| 8| 4| | 1| 4| 5| 8| 0| 3| 3| 0| 3| 3| 3| 2| 1| 8| 6| 5| 5| 4| 2| 7| 1| 0| 9| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Gallbladder | + + M A + + A + + + + + + + M M + M M M + M M + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| Parasite Metazoan | X X X X X X X X X| Ulcer | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + M + + + + + +| Epithelium, Metaplasia, Squamous | | __________________________________________________________________________| Intestine Small, Ileum | + + + M + + + + + + + + + + + + A + M M + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X | Clear Cell Focus | X | Cytomegaly | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Eosinophilic Focus | X X X | Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hematopoietic Cell Proliferation | 2 | Infiltration Cellular, Mononuclear | | Cell | 2 | Infiltration Cellular, Mixed Cell | | Inflammation, Acute | 3 | Necrosis, Coagulative | 3 1 1 1 2 3 3 1 1 1 1| Thrombosis | X X | Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 2 1 1 1 | Hepatocyte, Necrosis | 1 1 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Acinus, Atrophy | 1 | Artery, Inflammation, Chronic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Hemorrhage | 3 | Hyperkeratosis | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 112 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 4| 3| 4| 5| 3| 3| 5| 3| 5| 5| 4| 6| 3| 4| 5| 6| 5| 4| 5| 3| 4| DAY ON TEST | 3| 2| 4| 9| 0| 7| 9| 0| 6| 5| 1| 7| 3| 0| 9| 2| 4| 9| 7| 2| 3| 7| 1| 8| 4| | 1| 4| 5| 8| 0| 3| 3| 0| 3| 3| 3| 2| 1| 8| 6| 5| 5| 4| 2| 7| 1| 0| 9| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Inflammation, Chronic Active | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Valve, Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + M + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + M + + +| Hyperplasia | 1 | Infarct | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + M + + +| Infarct | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + M + + + + + + + + + M M M + + M M M + M + + +| __________________________________________________________________________| Thyroid Gland | + + M + + + + + + + + + + + + + M + + + + + + + +| Follicle, Hyperplasia, Nodular | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + | Duct, Dilatation | 2 | __________________________________________________________________________| Prostate | + + M + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Myelofibrosis | 2 | Myeloid Cell, Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + + M + M + + + + + + + + + + + + + + M + + + + +| Hyperplasia, Lymphoid | 2| Pancreatic, Hematopoietic Cell | | Proliferation | | Sinus, Mandibular, Ectasia | 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + | Hematopoietic Cell Proliferation | 2 2 2 2 | Sinus, Ectasia | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 4 2 2 2 2 3 2 3 3 1 1 3| _____________________________________________________________________________________________________________________| Page 113 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 4| 3| 4| 5| 3| 3| 5| 3| 5| 5| 4| 6| 3| 4| 5| 6| 5| 4| 5| 3| 4| DAY ON TEST | 3| 2| 4| 9| 0| 7| 9| 0| 6| 5| 1| 7| 3| 0| 9| 2| 4| 9| 7| 2| 3| 7| 1| 8| 4| | 1| 4| 5| 8| 0| 3| 3| 0| 3| 3| 3| 2| 1| 8| 6| 5| 5| 4| 2| 7| 1| 0| 9| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | M + + M + + + + + + + + M + + M + M M + + + M M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Erosion | | Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Parasite Metazoan | X X X X X X X X X X X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolus, Infiltration Cellular, | | Histiocyte | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 2 2 3 2 2 2 2 3 2 3 2 3 2 2 2 | Artery, Inflammation, Subacute | | Glomerulus, Infiltration Cellular, | | Mononuclear Cell | 2 | Glomerulus, Inflammation, | | Membranoproliferative | 1 | __________________________________________________________________________| Urinary Bladder | + + M + + + + + + + + + + + + + + + + M + M + + +| _____________________________________________________________________________________________________________________| Page 114 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 3| 5| 5| 5| 4| 5| 5| 6| 3| 6| 3| 6| 4| 5| 5| 6| 5| 3| 6| 6| 5| 6| | DAY ON TEST | 3| 7| 2| 6| 6| 1| 8| 6| 7| 4| 3| 4| 3| 4| 3| 6| 0| 7| 2| 4| 1| 2| 0| 7| 3| | | 5| 4| 6| 3| 5| 2| 0| 1| 4| 8| 9| 9| 6| 2| 9| 8| 1| 2| 2| 5| 4| 3| 8| 2| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + M + M + M + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Gallbladder | + M M + + M M M + + + + M + + + + + + M + + + A +| 32 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X X X X X X X X X X| 20 | Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 | Epithelium, Metaplasia, Squamous | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + M + + M + + + + + + + + + M + + M + + + + + M M| 40 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + A +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X | 7 | Clear Cell Focus | X | 2 | Cytomegaly | 3 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3| 50 3.0| Eosinophilic Focus | X | 4 | Fatty Change | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0| Hematopoietic Cell Proliferation | 2 2 | 3 2.0| Infiltration Cellular, Mononuclear | | | Cell | | 1 2.0| Infiltration Cellular, Mixed Cell | 3 | 1 3.0| Inflammation, Acute | | 1 3.0| Necrosis, Coagulative | 3 2 3 1 2 2 1 1 2 1 1 1 1 2 3 2 1 2 | 29 1.7| Thrombosis | X X X X X | 7 | Bile Duct, Hyperplasia | 2 1 2 2 1 1 1 1 1 1 2 1 1 1| 26 1.2| Hepatocyte, Necrosis | | 3 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Infarct | 3| 1 3.0| Acinus, Atrophy | | 1 1.0| Artery, Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + M + M + M + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 115 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 3| 5| 5| 5| 4| 5| 5| 6| 3| 6| 3| 6| 4| 5| 5| 6| 5| 3| 6| 6| 5| 6| | DAY ON TEST | 3| 7| 2| 6| 6| 1| 8| 6| 7| 4| 3| 4| 3| 4| 3| 6| 0| 7| 2| 4| 1| 2| 0| 7| 3| | | 5| 4| 6| 3| 5| 2| 0| 1| 4| 8| 9| 9| 6| 2| 9| 8| 1| 2| 2| 5| 4| 3| 8| 2| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hemorrhage | | 1 3.0| Hyperkeratosis | 2 | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mucosa, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + +| 2 | Aorta, Inflammation, Chronic Active | 3 1| 2 2.0| __________________________________________________________________________|____________| Heart | + + + + + M + M + M + + + + + + + + + M + + + + +| 46 | Valve, Inflammation, Chronic Active | 1| 2 1.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia | | 1 1.0| Infarct | 4 | 1 4.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + +| 46 | Infarct | 4 | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + M + + + + + + + + M + + + M + + + + + M| 46 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + M + M + + + + M + + + + + + + + + M| 43 | __________________________________________________________________________|____________| Pituitary Gland | + M + + + M + M + M + + + M + + + + + + + + + + +| 37 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + M + M + M + + + + + + + + + + + + + + +| 45 | Follicle, Hyperplasia, Nodular | 1 2 2 1 2 1 1 | 9 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | | 1 | Duct, Dilatation | | 1 2.0| __________________________________________________________________________|____________| Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Myelofibrosis | 2 | 2 2.0| Myeloid Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 116 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 3| 5| 5| 5| 4| 5| 5| 6| 3| 6| 3| 6| 4| 5| 5| 6| 5| 3| 6| 6| 5| 6| | DAY ON TEST | 3| 7| 2| 6| 6| 1| 8| 6| 7| 4| 3| 4| 3| 4| 3| 6| 0| 7| 2| 4| 1| 2| 0| 7| 3| | | 5| 4| 6| 3| 5| 2| 0| 1| 4| 8| 9| 9| 6| 2| 9| 8| 1| 2| 2| 5| 4| 3| 8| 2| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + A + + + M + M + M + + + M + + + + + + + + + + +| 42 | Hyperplasia, Lymphoid | | 1 2.0| Pancreatic, Hematopoietic Cell | | | Proliferation | 2 | 1 2.0| Sinus, Mandibular, Ectasia | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + +| 10 | Hematopoietic Cell Proliferation | | 4 2.0| Sinus, Ectasia | 3 3 4 4 2| 6 3.2| __________________________________________________________________________|____________| Spleen | + + + + + M + M + + + + + + + + + + + + + + + + +| 48 | Hematopoietic Cell Proliferation | 2 2 2 3 3 2 3 3 2 3 3 2 3 2 4 4 2 3| 32 2.5| Hyperplasia, Lymphoid | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + M + + M M M M M M + M + + M + M + M + M M + M| 28 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Acanthosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0| Erosion | 2 | 1 2.0| Hyperkeratosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.0| Parasite Metazoan | X X X X X X X X X X | 21 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + M + M + M + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + M + M + M + + + + + + + + + M + + + + +| 46 | Alveolus, Infiltration Cellular, | | | Histiocyte | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + M + M + M + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Nephropathy, Chronic | 2 3 2 3 2 2 3 2 2 2 2 1 3 3| 29 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 117 NTP Experiment-Test: 05077-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 11:21:20 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 3| 5| 5| 5| 4| 5| 5| 6| 3| 6| 3| 6| 4| 5| 5| 6| 5| 3| 6| 6| 5| 6| | DAY ON TEST | 3| 7| 2| 6| 6| 1| 8| 6| 7| 4| 3| 4| 3| 4| 3| 6| 0| 7| 2| 4| 1| 2| 0| 7| 3| | | 5| 4| 6| 3| 5| 2| 0| 1| 4| 8| 9| 9| 6| 2| 9| 8| 1| 2| 2| 5| 4| 3| 8| 2| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Artery, Inflammation, Subacute | 3 3 | 2 3.0| Glomerulus, Infiltration Cellular, | | | Mononuclear Cell | | 1 2.0| Glomerulus, Inflammation, | | | Membranoproliferative | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 118 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