TDMS Study 05077-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
NTP Experiment-Test: 05077-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
Facility: Battelle Columbus Laboratory
Chemical CAS #: 67774327
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 10 10 9 12 8 10
Natural Death 1 1 2 3 2
Survivors
Terminal Sacrifice 40 39 39 36 39 38
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (10) (11) (13) (10) (12)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (8%)
Intestine Large, Colon (50) (11) (12) (13) (11) (12)
Diverticulum 1 (8%)
Parasite Metazoan 2 (4%) 1 (9%)
Intestine Large, Rectum (50) (11) (11) (13) (9) (12)
Parasite Metazoan 1 (2%) 1 (8%)
Liver (50) (50) (50) (50) (50) (50)
Angiectasis 1 (2%) 4 (8%) 1 (2%)
Basophilic Focus 47 (94%) 44 (88%) 40 (80%) 37 (74%) 36 (72%) 23 (46%)
Clear Cell Focus 3 (6%)
Cytomegaly 1 (2%)
Degeneration, Cystic 2 (4%) 2 (4%) 3 (6%)
Eosinophilic Focus 3 (6%) 19 (38%) 19 (38%) 47 (94%) 45 (90%) 45 (90%)
Eosinophilic Focus, Multiple 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Hypertrophy 9 (18%) 32 (64%) 39 (78%) 40 (80%)
Inflammation, Chronic, Multifocal 21 (42%) 8 (16%) 7 (14%)
Inflammation, Chronic Active 34 (68%) 12 (24%) 19 (38%) 13 (26%) 12 (24%) 8 (16%)
Necrosis 3 (6%) 1 (2%) 5 (10%) 5 (10%) 5 (10%)
Vacuolization Cytoplasmic 3 (6%) 6 (12%) 18 (36%) 47 (94%) 43 (86%) 43 (86%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 14 (28%) 18 (36%) 34 (68%) 39 (78%) 38 (76%) 44 (88%)
Oval Cell, Hyperplasia 12 (24%) 19 (38%) 34 (68%)
Periportal, Infiltration Cellular, Lymphocyte 2 (4%)
Subserosa, Congestion, Multifocal 1 (2%)
Mesentery (2) (1) (1) (1) (1) (4)
Inflammation, Chronic Active 1 (50%) 1 (100%) 1 (100%) 1 (100%) 1 (100%) 3 (75%)
Pancreas (49) (12) (11) (13) (9) (12)
Ectopic Liver 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy 15 (31%) 2 (17%) 3 (27%) 4 (31%) 4 (44%) 3 (25%)
Stomach, Forestomach (50) (49) (50) (50) (50) (49)
Acanthosis 1 (2%) 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Diverticulum 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Submucosa, Foreign Body 1 (2%)
Stomach, Glandular (50) (48) (50) (50) (50) (50)
Hyperplasia, Focal 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 5 (10%) 3 (6%) 6 (12%) 10 (20%)
Ulcer 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (11) (12) (14) (11) (12)
Degeneration, Chronic 42 (84%) 3 (27%) 4 (33%) 3 (21%) 1 (9%) 1 (8%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (10) (12) (14) (9) (12)
Cyst 1 (11%)
Hyperplasia 39 (78%) 6 (60%) 2 (17%) 3 (21%) 1 (11%) 2 (17%)
Hypertrophy 15 (30%) 1 (10%) 3 (25%) 1 (7%)
Hypertrophy, Focal 1 (8%)
Necrosis 2 (17%) 1 (7%) 1 (11%) 1 (8%)
Vacuolization Cytoplasmic 17 (34%) 4 (40%) 3 (25%) 6 (43%) 1 (11%) 6 (50%)
Adrenal Gland, Medulla (48) (10) (12) (13) (9) (12)
Hyperplasia 6 (13%) 1 (8%)
Pituitary Gland (50) (34) (27) (29) (28) (27)
Hyperplasia 1 (3%)
Pars Distalis, Cyst 20 (40%) 9 (26%) 1 (4%) 5 (17%) 8 (29%) 3 (11%)
Pars Distalis, Hyperplasia 13 (26%) 7 (21%) 6 (22%) 3 (10%) 6 (21%) 8 (30%)
Thyroid Gland (50) (12) (15) (14) (10) (13)
Atrophy 1 (10%)
Infiltration Cellular, Lymphocyte 1 (10%)
C-Cell, Hyperplasia 50 (100%) 11 (92%) 12 (80%) 12 (86%) 10 (100%) 12 (92%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (15) (12) (16) (10) (13)
Hyperplasia 1 (7%) 1 (8%) 1 (6%) 1 (8%)
Inflammation, Chronic Active 24 (48%) 13 (87%) 10 (83%) 6 (38%) 3 (30%) 5 (38%)
Duct, Dilatation 19 (38%) 3 (25%) 8 (50%) 3 (30%) 4 (31%)
Ovary (50) (23) (19) (22) (14) (20)
Infiltration Cellular, Lymphocyte 3 (6%)
Follicle, Cyst 3 (6%) 1 (4%) 1 (5%)
Periovarian Tissue, Cyst 9 (18%) 11 (48%) 8 (42%) 9 (41%) 3 (21%) 8 (40%)
Uterus (50) (17) (18) (18) (21) (20)
Dilatation 7 (14%) 1 (6%) 1 (6%)
Fibrosis 1 (6%)
Hemorrhage 2 (10%)
Inflammation, Acute 1 (5%)
Necrosis 1 (5%)
Cervix, Cyst 1 (2%) 2 (11%) 3 (15%)
Endometrium, Hyperplasia, Cystic, Glandular 4 (24%) 4 (22%) 1 (6%) 7 (33%) 6 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (11) (11) (14) (12) (12)
Mandibular, Hyperplasia 1 (2%)
Mandibular, Necrosis 1 (8%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Lymph Node, Mesenteric (4) (2) (3) (1) (1) (3)
Angiectasis 1 (100%)
Cyst 1 (50%)
Hyperplasia, Lymphoid 1 (25%)
Infiltration Cellular, Histiocyte 1 (25%)
Sinus, Ectasia 2 (50%)
Spleen (50) (50) (50) (50) (49) (49)
Depletion Lymphoid 1 (2%) 1 (2%)
Fibrosis 1 (2%) 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Capsule, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (16) (13) (21) (16) (11)
Hyperplasia, Cystic 46 (96%) 10 (63%) 10 (77%) 13 (62%) 10 (63%) 9 (82%)
Skin (50) (11) (12) (13) (11) (14)
Subcutaneous Tissue, Lip, Foreign Body 1 (8%)
Subcutaneous Tissue, Lip, Inflammation,
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Chronic Active 1 (8%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (11) (11) (14) (11) (12)
Cranium, Fracture 1 (9%)
Femur, Hyperostosis 1 (9%) 1 (9%) 2 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (11) (14) (10) (12)
Compression 7 (14%) 3 (27%) 3 (27%) 3 (21%) 3 (30%) 1 (8%)
Hemorrhage 1 (9%)
Hydrocephalus 3 (27%) 3 (27%) 3 (21%) 3 (30%) 1 (8%)
Necrosis 1 (2%)
Spinal Cord (2) (2) (1) (1) (1)
Nerve, Demyelination 2 (100%) 2 (100%) 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (11) (11) (14) (9) (11)
Interstitium, Inflammation, Chronic Active 1 (7%) 1 (9%)
Nose (50) (11) (11) (13) (10) (12)
Mucosa, Inflammation, Chronic Active 1 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (3) (2) (4) (3) (5)
Choroid, Hemorrhage 1 (33%)
Lens, Cataract 4 (100%) 2 (67%) 1 (50%) 4 (100%) 3 (100%) 5 (100%)
Retina, Atrophy 4 (100%) 2 (67%) 1 (50%) 4 (100%) 3 (100%) 5 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (11) (11) (14) (11) (12)
Hydronephrosis 1 (9%)
Nephropathy, Chronic 25 (51%) 7 (64%) 8 (73%) 11 (79%) 8 (73%) 8 (67%)
Cortex, Infarct 1 (7%)
Renal Tubule, Mineralization 3 (6%) 2 (14%)
Urinary Bladder (50) (11) (11) (14) (10) (12)
Calculus Micro Observation Only 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mucosa, Hyperplasia, Papillary 1 (9%) 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Natural Death 5 2
Moribund Sacrifice 10 15
Survivors
Terminal Sacrifice 34 32
Natural Death 1 1
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (50)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (47) (49)
Parasite Metazoan 6 (13%) 1 (2%)
Liver (50) (50)
Basophilic Focus 11 (22%) 13 (26%)
Cytomegaly 1 (2%)
Eosinophilic Focus 48 (96%) 47 (94%)
Hypertrophy 17 (34%) 6 (12%)
Inflammation, Chronic, Multifocal 31 (62%) 22 (44%)
Inflammation, Chronic Active 3 (6%) 2 (4%)
Inflammation, Multifocal 1 (2%)
Necrosis 1 (2%) 3 (6%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 50 (100%) 40 (80%)
Bile Duct, Cyst 2 (4%) 5 (10%)
Bile Duct, Fibrosis 3 (6%) 19 (38%)
Bile Duct, Hyperplasia 50 (100%) 15 (30%)
Bile Duct, Metaplasia 1 (2%)
Oval Cell, Hyperplasia 42 (84%) 44 (88%)
Pancreas (50) (50)
Focal Cellular Change, Multiple 1 (2%)
Acinus, Atrophy 29 (58%) 25 (50%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Salivary Glands (49) (49)
Cytomegaly, Focal 1 (2%)
Acinus, Atrophy 1 (2%) 2 (4%)
Stomach, Forestomach (48) (50)
Acanthosis 5 (10%)
Inflammation, Chronic Active 1 (2%) 3 (6%)
Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (49) (50)
Dysplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50)
Degeneration, Chronic 21 (43%) 11 (22%)
Myocardium, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Cyst 2 (4%)
Hyperplasia 19 (38%) 21 (42%)
Hypertrophy 9 (18%) 9 (18%)
Vacuolization Cytoplasmic 18 (36%) 25 (50%)
Adrenal Gland, Medulla (49) (49)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (46) (49)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 13 (26%) 13 (26%)
Thyroid Gland (48) (48)
C-Cell, Hyperplasia 43 (90%) 47 (98%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (46)
Inflammation, Chronic Active 22 (47%) 13 (28%)
Duct, Dilatation 26 (55%) 23 (50%)
Ovary (48) (49)
Follicle, Cyst 1 (2%)
Periovarian Tissue, Cyst 11 (23%) 9 (18%)
Rete Ovarii, Hyperplasia 1 (2%)
Oviduct (1)
Dilatation 1 (100%)
Uterus (49) (50)
Dilatation 1 (2%)
Cervix, Cyst 2 (4%)
Cervix, Mucosa, Hyperplasia, Squamous 1 (2%)
Endometrium, Hyperplasia, Cystic, Glandular 12 (24%) 11 (22%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (49) (47)
Mandibular, Angiectasis 1 (2%)
Mandibular, Infiltration Cellular, Plasma
Cell 1 (2%)
Mediastinal, Angiectasis 1 (2%)
Lymph Node, Mesenteric (5)
Angiectasis 1 (20%)
Spleen (50) (50)
Hematopoietic Cell Proliferation 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (48)
Hyperplasia, Cystic 47 (96%) 43 (90%)
Skin (49) (50)
Acanthosis 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50)
Femur, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50)
Compression 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (47) (50)
Inflammation, Focal, Granulomatous 1 (2%)
Metaplasia, Focal, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%)
Interstitium, Inflammation, Chronic Active 1 (2%)
Nose (48) (50)
Mucosa, Inflammation, Chronic Active 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (5)
Lens, Cataract 1 (50%) 4 (80%)
Retina, Atrophy 1 (50%) 4 (80%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Nephropathy, Chronic 37 (74%) 42 (84%)
Renal Tubule, Inflammation, Acute, Multifocal 1 (2%)
Renal Tubule, Mineralization 2 (4%)
Urinary Bladder (49) (50)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50 50
Early Deaths
Natural Death 5 4 1 6 5 4
Moribund Sacrifice 16 16 15 21 25 26
Survivors
Natural Death 1
Terminal Sacrifice 29 29 34 22 19 19
Moribund Sacrifice 1 1 1
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (20) (16) (26) (30) (29)
Dilatation 1 (5%) 1 (4%)
Inflammation, Chronic Active 1 (3%)
Ulcer 1 (3%)
Intestine Large, Colon (49) (21) (16) (27) (31) (30)
Dilatation 1 (5%)
Parasite Metazoan 3 (6%) 1 (5%) 1 (3%)
Intestine Large, Rectum (49) (21) (16) (27) (30) (30)
Parasite Metazoan 3 (6%) 1 (6%) 1 (4%) 2 (7%)
Intestine Small, Duodenum (48) (21) (16) (27) (31) (30)
Ulcer 1 (3%)
Intestine Small, Ileum (49) (19) (16) (28) (29) (29)
Parasite Metazoan 1 (3%)
Liver (50) (50) (50) (49) (50) (50)
Angiectasis 4 (8%) 1 (2%)
Basophilic Focus 27 (54%) 19 (38%) 36 (72%) 28 (57%) 8 (16%) 15 (30%)
Clear Cell Focus 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%)
Degeneration, Cystic 18 (36%) 12 (24%) 12 (24%) 5 (10%) 3 (6%) 7 (14%)
Eosinophilic Focus 18 (36%) 29 (58%) 40 (80%) 44 (90%) 42 (84%) 47 (94%)
Hepatodiaphragmatic Nodule 4 (8%) 1 (2%)
Hyperplasia, Focal 2 (4%) 1 (2%)
Hyperplasia, Multifocal 2 (4%)
Hypertrophy 3 (6%) 34 (68%) 27 (55%) 29 (58%) 27 (54%)
Infarct 1 (2%)
Inflammation, Chronic 4 (8%) 2 (4%)
Inflammation, Chronic, Multifocal 1 (2%) 13 (26%) 6 (12%) 4 (8%) 4 (8%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 4 (8%) 1 (2%) 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 5 (10%) 18 (36%) 42 (84%) 28 (57%) 28 (56%) 32 (64%)
Bile Duct, Hyperplasia 48 (96%) 45 (90%) 49 (98%) 48 (98%) 47 (94%) 49 (98%)
Centrilobular, Degeneration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis 1 (2%)
Oval Cell, Hyperplasia 2 (4%) 4 (8%) 11 (22%) 13 (26%) 23 (46%)
Portal Vein, Thrombosis 1 (2%)
Mesentery (6) (3) (1) (2)
Inflammation, Chronic Active 1 (17%) 1 (33%)
Artery, Inflammation, Chronic Active 2 (67%)
Pancreas (49) (21) (16) (27) (32) (31)
Fibrosis 1 (6%)
Inflammation, Chronic Active 1 (6%)
Necrosis 1 (3%)
Acinus, Atrophy 23 (47%) 7 (33%) 8 (50%) 13 (48%) 12 (38%) 16 (52%)
Acinus, Cytomegaly, Focal 1 (4%)
Acinus, Hyperplasia 2 (4%) 1 (3%)
Duct, Hyperplasia 1 (4%)
Stomach, Forestomach (50) (49) (48) (49) (50) (50)
Acanthosis 4 (8%) 3 (6%) 7 (14%) 7 (14%) 8 (16%)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Erosion 1 (2%)
Foreign Body 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 6 (12%) 5 (10%) 5 (10%)
Mineralization 1 (2%)
Ulcer 1 (2%) 5 (10%) 3 (6%) 4 (8%)
Stomach, Glandular (50) (48) (48) (48) (50) (49)
Dysplasia 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (21) (16) (27) (31) (31)
Degeneration, Chronic 50 (100%) 12 (57%) 9 (56%) 23 (85%) 22 (71%) 23 (74%)
Thrombosis 1 (5%) 1 (6%) 1 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (21) (15) (28) (31) (30)
Atrophy 1 (3%)
Degeneration, Cystic 1 (3%) 1 (3%)
Hyperplasia 19 (38%) 4 (19%) 4 (27%) 9 (32%) 5 (16%) 4 (13%)
Hypertrophy 8 (16%) 1 (5%) 1 (4%) 2 (7%)
Necrosis 1 (7%) 1 (3%)
Vacuolization Cytoplasmic 11 (22%) 10 (48%) 7 (47%) 6 (21%) 15 (48%) 14 (47%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Gland, Medulla (49) (22) (16) (29) (32) (30)
Hyperplasia 13 (27%) 3 (14%) 1 (6%) 6 (21%) 1 (3%) 3 (10%)
Islets, Pancreatic (49) (21) (16) (27) (31) (30)
Hyperplasia 1 (2%) 1 (3%)
Necrosis 1 (3%)
Parathyroid Gland (43) (21) (16) (27) (31) (29)
Hyperplasia 1 (3%)
Pituitary Gland (50) (27) (22) (32) (30) (34)
Pars Distalis, Cyst 3 (6%) 3 (11%) 1 (5%) 2 (7%) 1 (3%)
Pars Distalis, Hemorrhage 1 (3%)
Pars Distalis, Hyperplasia 9 (18%) 5 (19%) 1 (5%) 8 (25%) 6 (20%) 8 (24%)
Pars Intermedia, Hyperplasia, Glandular 1 (4%)
Thyroid Gland (49) (23) (17) (28) (31) (30)
C-Cell, Hyperplasia 48 (98%) 20 (87%) 16 (94%) 28 (100%) 30 (97%) 29 (97%)
Follicle, Cyst 1 (6%) 1 (3%)
Follicular Cell, Hyperplasia 1 (3%)
Follicular Cell, Hypertrophy 2 (4%) 1 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (20) (16) (28) (30) (30)
Inflammation, Chronic Active 2 (7%)
Preputial Gland (47) (25) (20) (32) (34) (32)
Hyperplasia 3 (6%) 1 (4%)
Inflammation, Chronic Active 37 (79%) 15 (60%) 14 (70%) 27 (84%) 23 (68%) 25 (78%)
Duct, Dilatation 1 (2%) 3 (12%) 2 (6%) 1 (3%) 1 (3%)
Duct, Hyperplasia, Squamous 3 (9%)
Prostate (50) (21) (16) (28) (30) (31)
Inflammation, Acute 1 (3%)
Inflammation, Chronic Active 11 (22%) 4 (19%) 2 (13%) 8 (29%) 5 (17%) 10 (32%)
Metaplasia, Squamous 11 (22%) 1 (3%) 3 (10%)
Seminal Vesicle (2) (3) (1) (1)
Dilatation 1 (50%) 2 (67%) 1 (100%)
Epithelium, Hyperplasia 1 (50%)
Testes (50) (49) (50) (50) (50) (50)
Interstitial Cell, Hyperplasia 8 (16%) 3 (6%) 1 (2%) 3 (6%) 9 (18%) 4 (8%)
Seminiferous Tubule, Atrophy 3 (6%) 2 (4%) 5 (10%) 1 (2%) 3 (6%)
Seminiferous Tubule, Mineralization 1 (2%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (21) (15) (27) (31) (30)
Femoral, Atrophy 1 (7%)
Femoral, Hyperplasia, Reticulum Cell 1 (2%)
Femoral, Myelofibrosis 1 (3%)
Lymph Node (50) (23) (18) (27) (33) (31)
Mandibular, Hemorrhage 1 (2%)
Mandibular, Hyperplasia, Lymphoid 3 (10%)
Mediastinal, Congestion 1 (3%)
Mediastinal, Hemorrhage 1 (6%)
Mediastinal, Hyperplasia, Macrophage 1 (4%)
Lymph Node, Mesenteric (2) (3) (2) (9) (8) (4)
Angiectasis 1 (11%)
Spleen (50) (50) (49) (49) (50) (50)
Depletion Lymphoid 1 (2%)
Fibrosis 1 (2%) 2 (4%) 6 (12%) 4 (8%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Capsule, Cyst 1 (2%)
Capsule, Hemorrhage 1 (2%)
Thymus (47) (17) (15) (22) (24) (27)
Depletion Lymphoid 1 (4%)
Inflammation, Chronic Active 1 (7%)
Necrosis 1 (7%) 1 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (14) (14) (23) (20) (18)
Hyperplasia, Cystic 38 (97%) 14 (100%) 12 (86%) 19 (83%) 20 (100%) 18 (100%)
Skin (50) (26) (22) (31) (32) (32)
Acanthosis 1 (3%)
Necrosis 1 (2%)
Face, Cyst Epithelial Inclusion 1 (4%)
Subcutaneous Tissue, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (21) (16) (29) (31) (31)
Compression 3 (6%) 2 (13%) 1 (3%) 4 (13%)
Gliosis 1 (5%)
Hemorrhage 1 (2%) 2 (10%) 4 (14%) 2 (6%) 1 (3%)
Hydrocephalus 2 (13%) 2 (6%) 4 (13%)
Spinal Cord (2) (1) (1)
Hemorrhage 1 (100%)
Nerve, Demyelination 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (21) (17) (28) (32) (31)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (5%) 1 (4%) 1 (3%)
Interstitium, Inflammation, Chronic Active 3 (6%) 2 (10%) 1 (3%)
Nose (50) (21) (16) (27) (31) (30)
Foreign Body 1 (3%)
Mucosa, Inflammation, Acute 1 (3%)
Mucosa, Inflammation, Chronic Active 1 (2%) 1 (5%) 1 (6%) 2 (6%) 1 (3%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (4) (7) (4) (3)
Cornea, Inflammation, Chronic Active 1 (33%)
Lens, Cataract 1 (100%) 2 (50%) 7 (100%) 4 (100%) 2 (67%)
Retina, Atrophy 1 (100%) 3 (75%) 7 (100%) 4 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (24) (20) (32) (32) (37)
Hydronephrosis 1 (2%) 2 (8%)
Nephropathy, Chronic 50 (100%) 23 (96%) 19 (95%) 32 (100%) 32 (100%) 36 (97%)
Cortex, Cyst 1 (4%) 1 (5%) 2 (6%) 1 (3%) 1 (3%)
Urinary Bladder (49) (20) (17) (27) (31) (30)
Calculus Micro Observation Only 1 (6%)
Hemorrhage 1 (2%) 1 (5%) 1 (3%)
Inflammation, Acute 1 (3%)
Mucosa, Hyperplasia 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mucosa, Ulcer 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Moribund Sacrifice 23 24
Natural Death 3 7
Survivors
Moribund Sacrifice 1 1
Terminal Sacrifice 23 18
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (47)
Parasite Metazoan 2 (4%)
Intestine Large, Rectum (48) (46)
Parasite Metazoan 1 (2%)
Intestine Small, Duodenum (48) (48)
Ulcer 1 (2%)
Liver (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 8 (16%) 5 (10%)
Clear Cell Focus 1 (2%) 1 (2%)
Congestion 1 (2%)
Degeneration, Cystic 1 (2%) 3 (6%)
Eosinophilic Focus 46 (92%) 46 (92%)
Fibrosis 2 (4%)
Hypertrophy 17 (34%) 15 (30%)
Infarct 2 (4%)
Inflammation, Chronic, Multifocal 4 (8%) 5 (10%)
Metaplasia 1 (2%) 1 (2%)
Necrosis 1 (2%) 4 (8%)
Vacuolization Cytoplasmic 34 (68%) 37 (74%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 49 (98%) 49 (98%)
Oval Cell, Hyperplasia 37 (74%) 41 (82%)
Serosa, Fibrosis 1 (2%)
Pancreas (49) (50)
Acinus, Atrophy 35 (71%) 29 (58%)
Acinus, Cytomegaly 1 (2%)
Acinus, Hyperplasia 2 (4%) 1 (2%)
Stomach, Forestomach (50) (50)
Acanthosis 11 (22%) 6 (12%)
Acanthosis, Focal 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Erosion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 9 (18%) 3 (6%)
Ulcer 6 (12%) 2 (4%)
Stomach, Glandular (50) (49)
Erosion 1 (2%)
Hyperplasia, Focal 1 (2%)
Mineralization 1 (2%)
Ulcer 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49)
Degeneration, Chronic 40 (80%) 34 (69%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50)
Capsule, Spindle Cell, Hyperplasia 1 (2%)
Adrenal Gland, Cortex (50) (50)
Hyperplasia 17 (34%) 13 (26%)
Hypertrophy 7 (14%) 2 (4%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 10 (20%) 15 (30%)
Capsule, Ectopic Tissue 1 (2%)
Adrenal Gland, Medulla (50) (50)
Hyperplasia 4 (8%) 5 (10%)
Islets, Pancreatic (49) (50)
Hyperplasia 4 (8%)
Parathyroid Gland (49) (47)
Cyst 1 (2%)
Hyperplasia 2 (4%)
Hypertrophy 1 (2%)
Pituitary Gland (48) (49)
Pars Distalis, Hyperplasia 10 (21%) 10 (20%)
Pars Distalis, Vacuolization Cytoplasmic 1 (2%)
Thyroid Gland (49) (49)
Inflammation, Chronic 1 (2%)
C-Cell, Hyperplasia 47 (96%) 48 (98%)
Follicle, Cyst 1 (2%)
Follicle, Hyperplasia, Cystic 1 (2%)
Follicular Cell, Cytoplasmic Alteration 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
Follicular Cell, Hypertrophy 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50)
Inflammation, Chronic Active 3 (6%) 3 (6%)
Preputial Gland (44) (49)
Inflammation, Chronic Active 34 (77%) 36 (73%)
Duct, Dilatation 3 (7%) 6 (12%)
Duct, Hyperplasia, Squamous 2 (5%)
Prostate (49) (50)
Dilatation 1 (2%)
Inflammation, Chronic Active 7 (14%) 10 (20%)
Metaplasia, Squamous 3 (6%) 8 (16%)
Testes (50) (50)
Interstitial Cell, Hyperplasia 7 (14%) 12 (24%)
Seminiferous Tubule, Atrophy 6 (12%) 11 (22%)
Seminiferous Tubule, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Femoral, Hyperplasia, Neutrophil 1 (2%)
Lymph Node (49) (49)
Mandibular, Hyperplasia, Lymphoid 1 (2%)
Mandibular, Inflammation, Chronic, Multifocal 1 (2%)
Sinus, Mandibular, Ectasia 1 (2%)
Spleen (50) (50)
Fibrosis 10 (20%) 6 (12%)
Hematopoietic Cell Proliferation 1 (2%)
Thrombosis, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (30)
Hyperplasia, Cystic 37 (95%) 30 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Compression 1 (2%)
Hydrocephalus 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49)
Alveolar Epithelium, Hyperplasia 4 (8%) 2 (4%)
Bronchiole, Epithelium, Hyperplasia 1 (2%)
Interstitium, Inflammation, Chronic Active 2 (4%) 1 (2%)
Nose (49) (50)
Hemorrhage, Subacute 1 (2%)
Mucosa, Inflammation, Chronic Active 3 (6%) 5 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (4)
Cornea, Inflammation, Chronic Active 1 (20%)
Lens, Cataract 3 (60%) 1 (25%)
Retina, Atrophy 3 (60%) 1 (25%)
Harderian Gland (1)
Acinus, Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Inflammation, Chronic, Multifocal 1 (2%)
Nephropathy, Chronic 50 (100%) 50 (100%)
Cortex, Cyst 1 (2%) 1 (2%)
Urinary Bladder (48) (50)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
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