Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2453

TDMS Study 05077-01 Pathology Tables

NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97
Route: DOSED FEED                                                                                                 Time: 08:19:31




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  67774-32-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|             
                                           | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                      X     X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Mesothelioma Malignant, Multifocal   |                            X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                                                          X               |             
      Bilateral, Pheochromocytoma Benign   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X  X     X     X     X     X  X           X     X                 X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                     X                                    |             
      C-Cell, Adenoma                      |             X                             X  X                    X  X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|             
                                           | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |    X                                                                     |             
      Polyp Stromal                        | X              X                                X                    X   |             
      Schwannoma Malignant                 |                                                                          |             
      Epithelium, Adenoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |                      X                                      X            |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +           +                                             |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                      X     X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |       X                                                                  |             
      Squamous Cell Papilloma              |                                           X                              |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
      Abdominal, Mesothelioma Malignant,   |                                                                          |             
           Multifocal                      |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                       X                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +              +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|             
                                           | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +           +                                   +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                      X     X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X              X     X        X  X  X     X              X         |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +                              |   2        |
      Mesothelioma Malignant, Multifocal   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
      Pheochromocytoma Benign              |                                                                      X   |          2 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Adenoma                              |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |    X              X  X                 X  X        X  X     X  X     X   |         21 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |    X           X     X                    X                    X         |         10 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |       X                    X  X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       | X                                                                        |          2 |
      Polyp Stromal                        |                      X     X                       X                     |          7 |
      Schwannoma Malignant                 |                                        X                                 |          1 |
      Epithelium, Adenoma                  |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Leukemia Mononuclear     |                                        X  X     X              X         |          6 |
      Mediastinal, Leukemia Mononuclear    |                                                 X                        |          1 |
      Renal, Leukemia Mononuclear          |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                           +     +                        |   4        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X              X     X        X  X  X     X              X     X   |         14 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibroadenoma                         |                      X           X     X                             X   |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Trichoepithelioma                    |    X                                                                     |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Abdominal, Mesothelioma Malignant,   |                                                                          |            |
           Multifocal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                 X              X         |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                      +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X              X     X        X  X  X     X              X     X   |         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|             
                                           | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          M              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +              +                                +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +              +                                +  +     +      |             
      Schwannoma Malignant                 |                                                          X               |             
      Serosa, Adenocarcinoma, Metastatic,  |                                                                          |             
           Uterus                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                          X  X           X     X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +              +                    +              +     +      |             
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Adenocarcinoma, Metastatic,  |                                                                          |             
           Uterus                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +               |             
      Squamous Cell Papilloma              |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +              +                                   +     +      |             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +              +                                   +     +      |             
      Capsule, Adenocarcinoma, Metastatic, |                                                                          |             
           Uterus                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +              +                                   +     +      |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +              +                                   +     +      |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +              +                    +              +     +      |             
      Carcinoma                            |                                              X                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +           +  +                    +  +  +     +  +     +      |             
      Pars Distalis, Adenoma               |    X  X              X  X                    X  X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|             
                                           | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +              +     +                             +     +      |             
      C-Cell, Adenoma                      |          X                    X                                          |             
      C-Cell, Adenoma, Moderate            |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +              +                 +                 +     +  +   |             
      Adenoma                              |                                                                          |             
      Bilateral, Adenoma                   |                                           X                              |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +        +     +     +  +           +     +        +     +      |             
      Periovarian Tissue, Adenocarcinoma,  |                                                                          |             
           Metastatic, Uterus              |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |          +              +     +  +                          +     +      |             
      Adenocarcinoma                       |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          M              +                                   +     +      |             
      Mandibular, Leukemia Mononuclear     |                                                             X            |             
      Mediastinal, Adenocarcinoma,         |                                                                          |             
          Metastatic, Uterus               |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X  X                       X  X           X     X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +              +                                   M     +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +              +                 +              +  M     +      |             
      Carcinoma                            |                                                          X               |             
      Fibroadenoma                         |    X  X  X                                X                              |             
                                            __________________________________________________________________________|             
   Skin                                    |          +              +                                   +     +      |             
      Subcutaneous Tissue, Fibroma         |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +              +                                   +     +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|             
                                           | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +              +                                   +     +      |             
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +              +                                   +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +              +                                   +     +      |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +              +                                   +     +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X  X                       X  X           X     X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +     +                    +  +     +           +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +                    +  +     +           +                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +                    +  +     +           +                  |  12        |
      Schwannoma Malignant                 |                                                                          |          1 |
      Serosa, Adenocarcinoma, Metastatic,  |                                                                          |            |
           Uterus                          |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +     +                    +  +                 +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +     +                    +  +                 +                  |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X        X  X                                      X              X  X|         12 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +     +                    +  +     +           +                  |  12        |
      Adenocarcinoma, Metastatic, Uterus   |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Serosa, Adenocarcinoma, Metastatic,  |                                                                          |            |
           Uterus                          |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +                    +  +     +           +                  |  11        |
      Leukemia Mononuclear                 |             X                                                            |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +     +                    +  +     +           +                  |  11        |
      Capsule, Adenocarcinoma, Metastatic, |                                                                          |            |
           Uterus                          |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +     +                    +  +                 +                  |  10        |
      Adenoma                              | X                                                                        |          1 |
      Leukemia Mononuclear                 |             X                                         X                  |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +     +                    +  +                 +                  |  10        |
      Leukemia Mononuclear                 |             X                                         X                  |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +     +                    +  +     +           +                  |  12        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M     +                    +  +     M           +                  |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  34        |
      Pars Distalis, Adenoma               | X     X  X     X  X     X     X  X     X     X     X        X     X      |         19 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +     +                    +  +     +           +                  |  12        |
      C-Cell, Adenoma                      |       X                                   X                              |          4 |
      C-Cell, Adenoma, Moderate            | X                                                                        |          1 |
      C-Cell, Carcinoma                    |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +     +                 +  +  +  +  M           +                  |  15        |
      Adenoma                              |                                        X                                 |          1 |
      Bilateral, Adenoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +     +  +           +     +  +     +  +        +     +     +  +   |  23        |
      Periovarian Tissue, Adenocarcinoma,  |                                                                          |            |
           Metastatic, Uterus              |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +     +                    +  +     +           +     +  +     +  +|  17        |
      Adenocarcinoma                       |                                           X                              |          1 |
      Polyp Stromal                        |                                                             X  X     X  X|          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +  +                 +  +     +           +                  |  11        |
      Mandibular, Leukemia Mononuclear     |             X                                         X                  |          3 |
      Mediastinal, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Uterus               |                                           X                              |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +                          +                              |   2        |
      Adenocarcinoma, Metastatic, Uterus   |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X        X  X                                      X              X  X|         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +     +                    +  M     +           +                  |   9        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +     +        +           +  +     +           +  +               |  16        |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |                      X           X                       X               |          7 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +     +                    +  +     +           +                  |  11        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +     +                    +  +     +           +                  |  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                     +                                    |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +                    +  +     +           +                  |  11        |
      Adenocarcinoma, Metastatic, Uterus   |                                           X                              |          1 |
      Leukemia Mononuclear                 |             X                                         X                  |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +     +                    +  +     +           +                  |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +              +               |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +                    +  +     +           +                  |  11        |
      Leukemia Mononuclear                 |             X                                         X                  |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +                    +  +     +           +                  |  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X        X  X                                      X              X  X|         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|             
                                           | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +     +              +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +     +              +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +                    +        M           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                     X                                    |             
      Hepatocellular Adenoma, Multiple     |             X                                                            |             
      Leukemia Mononuclear                 | X           X                       X           X        X  X  X        X|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +                    +        +           +  +  +  +      |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +                    +        +           +  +  M  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
      Squamous Cell Papilloma              |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +                    +        +           +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +        +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +        +                    +        +           +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                       X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +        +                    +        +           +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                       X            |             
      Pheochromocytoma Malignant           |       X                                                                  |             
      Pheochromocytoma Benign              |                                                                X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +  +           +        +        +  +        +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |             X  X           X        X        X  X              X     X  X|             
      Pars Distalis, Leukemia Mononuclear  |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +                    +        +           +  +  +  +     +|             
      C-Cell, Adenoma                      |    X                                                           X         |             
      C-Cell, Carcinoma                    |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|             
                                           | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +     +     +  +  +  +     +        +           +  +  +  +      |             
      Granulosa-Theca Tumor Malignant      |                            X                                             |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |          +     +                    +        +  +     +  +  +  +  +      |             
      Adenocarcinoma                       |                                                       X           X      |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +                    +        +           +  +  +  +      |             
      Femoral, Leukemia Mononuclear        |                                     X                       X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                 +  +        +           +  +  M  +      |             
      Mandibular, Leukemia Mononuclear     |                                     X                    X  X            |             
      Mediastinal, Leukemia Mononuclear    |                                     X                    X  X            |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                  +  +                                    |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X                       X           X        X  X  X        X|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +                    +        +           +  +  +  +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +        +           M        +           +  +  +  +  +   |             
      Fibroadenoma                         |                         X                                            X   |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +                    +        +           +  +  +  +      |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +                    +        +           +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                    +        +           +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +                    +           +        +  +  +  +      |             
      Adenocarcinoma, Metastatic, Uterus   |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|             
                                           | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                     X                    X  X  X         |             
                                            __________________________________________________________________________|             
   Nose                                    |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +                    +        +           +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +                    +        +           +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +                    +        +           +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X                       X           X        X  X  X        X|             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8|            |
                                           | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                              +  +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                              +  +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                              +  +     +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                X                                                         |          2 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X        X  X           X  X     X     X        X        X  X  X   |         20 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                              +  +     +|  11        |
      Leukemia Mononuclear                 |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                              +  +     +|  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                              +  +     +|  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                                              +  +     +|  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                                              +  +     +|  12        |
      Leukemia Mononuclear                 |                                                                   X      |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                                              +  +     +|  12        |
      Leukemia Mononuclear                 |                                                                   X      |          3 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +        +     +  +     +           +  +  +  +  +     +  +  +  +|  27        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8|            |
                                           | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |                   X     X  X     X           X  X        X     X  X  X   |         19 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +                                               +        +  +     +|  15        |
      C-Cell, Adenoma                      | X                                                              X         |          4 |
      C-Cell, Carcinoma                    |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                +                             +  +     +|  12        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +  +        +                                         +  +     +|  19        |
      Granulosa-Theca Tumor Malignant      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +        +  +                                         +  +  +     +|  18        |
      Adenocarcinoma                       |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
      Polyp Stromal                        |       X        X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                              +  +     +|  11        |
      Femoral, Leukemia Mononuclear        |                                                                   X      |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                              +  +     +|  11        |
      Mandibular, Leukemia Mononuclear     | X                                                              X  X      |          6 |
      Mediastinal, Leukemia Mononuclear    |                                                                   X      |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                   +      |   3        |
      Leukemia Mononuclear                 |                                                                   X      |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X        X  X           X  X     X     X        X        X  X  X   |         20 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                              +  +     +|  11        |
      Leukemia Mononuclear                 |                                                                X  X      |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                    +                                         +  +     +|  13        |
      Fibroadenoma                         |                                                                          |          2 |
      Fibroadenoma, Multiple               |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8|            |
                                           | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                            +                 +  +     +|  12        |
      Subcutaneous Tissue, Fibrosarcoma    |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                              +  +     +|  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                              +  +     +|  11        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                              +  +     +|  11        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                              X  X      |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                              +  +     +|  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                              +  +     +|  11        |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                              +  +     +|  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X        X  X           X  X     X     X        X        X  X  X   |         20 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|             
                                           | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +                 +     +                    +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                    X           X        X|             
      Hepatocellular Adenoma, Multiple     |                X                 X                                       |             
      Leukemia Mononuclear                 | X     X  X              X  X     X  X     X     X  X     X     X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +                 +     +                    M        +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +                 +     +                    +        +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
      Squamous Cell Carcinoma              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +                 +     +                    +        +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +                 +     +                    A  +     +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +                 +     +                    A  +     +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +                 +     +                    A  +     +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +                 +     +                    M        +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +                 +     +                    +        +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +        +  +     +     +                    +  +  +  +     +|             
      Pars Distalis, Adenoma               |          X  X        X  X     X     X                          X        X|             
      Pars Intermedia, Adenoma             |                      X                                      X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +                 +     +                    A        +  +   |             
      C-Cell, Adenoma                      | X                             X                                          |             
      C-Cell, Carcinoma                    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|             
                                           | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +                 +     +                    +        +      |             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +  +           +     +                    +        +     +|             
      Periovarian Tissue, Leiomyoma        |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +           +  +     +                    +        +      |             
      Polyp Stromal                        |                            X                                             |             
      Sarcoma Stromal                      |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +                 +     +                    A        +      |             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +                 +     +                    +        +      |             
      Mandibular, Leukemia Mononuclear     |                                     X                                    |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X              X  X     X  X     X     X  X     X     X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +                 I     M                    +        +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +        +  +     +  +  +                    +        +     +|             
      Fibroadenoma                         |                      X  X        X                                      X|             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +                 +     +                    A        +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +                 +     +                    +        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +                 +     +                    +        +      |             
      Astrocytoma Malignant                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +                 +     +                    +        +      |             
      Leukemia Mononuclear                 | X                                   X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +                 +     +                    +        +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|             
                                           | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
      Carcinoma                            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +                 +     +                    +        +      |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +                 +     +                    +        +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X              X  X     X  X     X     X  X     X     X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                 +           +  +              +  M     +               |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                       X                 X|          2 |
      Hepatocellular Adenoma               |                                     X     X        X                     |          6 |
      Hepatocellular Adenoma, Multiple     |       X                                                        X         |          4 |
      Leukemia Mononuclear                 | X     X           X  X              X           X  X     X     X         |         21 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                 +           +  +              +  +     +               |  14        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +     +  +     +  +  +  +        +  +  +  +  +  +  +  +  +   |  29        |
      Pars Distalis, Adenoma               |             X     X        X     X  X        X              X  X  X  X   |         18 |
      Pars Intermedia, Adenoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                 +           +  +              +  +     +               |  14        |
      C-Cell, Adenoma                      |                                                          X               |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +              +     +     +  +              +  +     +               |  16        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +              +           +  +  +     +     +  +  +  +              +|  22        |
      Periovarian Tissue, Leiomyoma        |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +        +  +        +  +              +  +     +               |  18        |
      Polyp Stromal                        |          X           X                                                   |          3 |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                 +           +  +              +  +     +               |  13        |
      Femoral, Leukemia Mononuclear        |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                 +           +  +              +  +     +               |  14        |
      Mandibular, Leukemia Mononuclear     | X                 X                             X  X     X               |          6 |
      Mediastinal, Leukemia Mononuclear    | X                                                                        |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X        X  X              X           X  X     X     X         |         22 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                 +           M  +              +  +     +               |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +              +  +           +  M        +     +  +     +     +        +|  21        |
      Fibroadenoma                         | X              X  X                       X              X              X|         10 |
      Fibroadenoma, Multiple               |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +           +  +              +  +     +               |  13        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                 +           +  +              +  +     +               |  14        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                 +           +  +              +  +     +               |  14        |
      Astrocytoma Malignant                |                               X                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                 +           +  +              +  +     +               |  14        |
      Leukemia Mononuclear                 |                                                 X  X     X               |          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                 +           +  +              +  +     +               |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +     +                                            +         |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                 +           +  +              +  +     +               |  14        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                 +           +  +              +  +     +               |  14        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X        X  X              X           X  X     X     X         |         22 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|             
                                           | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +           +                    +           +  +        A  +  +   |             
      Leiomyosarcoma                       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +           +                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +           A                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               | X           X                       X        X              X           X|             
      Hepatocellular Adenoma, Multiple     |    X           X                          X                              |             
      Hepatocholangiocarcinoma             |          X                                                               |             
      Leukemia Mononuclear                 |    X           X                    X  X  X        X           X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
      Squamous Cell Carcinoma              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +           +                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +           A                    +           +  +        A  +  +   |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +           A                    +           +  +        A  +  +   |             
      Leukemia Mononuclear                 |                                                    X                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +           M                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +              +  +  +           +  +  +     +  +  +   |             
      Pars Distalis, Adenoma               | X                                   X                 X  X               |             
      Pars Intermedia, Adenoma             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +           A                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|             
                                           | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +           A                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +           +                    +        +  +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +           +                    +     +  +  +  +  +     +  +  +  +|             
      Polyp Stromal                        |                                                 X        X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +                    +           +  +        +  +  +   |             
      Mandibular, Leukemia Mononuclear     |                                        X           X           X         |             
      Mediastinal, Leukemia Mononuclear    |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X           X                    X  X  X        X           X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +           M                    +           +  +        +  +  +   |             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +        +  M                    +           +  +        +  +  +   |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                X                                                     X   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +           +                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +           +                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +           A                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +           +                    +           +  +        +  +      |             
      Leukemia Mononuclear                 |                                        X           X           X         |             
                                            __________________________________________________________________________|             
   Nose                                    |       +           A                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +           A                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +           A                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|             
                                           | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X           X                    X  X  X        X           X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|            |
                                           | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +              +                                                        +|  10        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +              +                                                        +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +              +                                                        +|  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             | X                                                                        |          1 |
      Hepatocellular Adenoma               | X                 X              X        X  X     X                     |         12 |
      Hepatocellular Adenoma, Multiple     |          X                          X  X              X  X        X  X   |         10 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X  X        X        X     X     X        X     X        X      |         17 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +              +                                                        +|  11        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +              +                                                        +|   9        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +              +                                                        +|   9        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +              M                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +        +  +     +  +  +     +  +  +     +     +  +     +  +     +|  28        |
      Pars Distalis, Adenoma               |       X        X        X     X        X        X     X  X               |         12 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|            |
                                           | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +              +                                                        +|  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +              +                                                        +|  10        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +              +  +                                            +        +|  14        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +     +                 +           +  +                 +|  21        |
      Polyp Stromal                        |          X           X                 X                                X|          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +                                         +              +|  12        |
      Mandibular, Leukemia Mononuclear     | X                                                                        |          4 |
      Mediastinal, Leukemia Mononuclear    |                                                          X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X        X  X        X        X     X     X        X     X        X      |         17 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M              +                                                        +|   9        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +              +     +  +     +              +              +           +|  16        |
      Adenoma                              |                                              X                           |          1 |
      Fibroadenoma                         |                X     X  X     X                             X            |          7 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +              +                                                        +|  11        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +                                                        +|  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +              +                                                        +|  10        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +              +                                                         |   9        |
      Leukemia Mononuclear                 | X                                                                        |          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +              +                                                        +|  10        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|            |
                                           | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +              +                                                        +|  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +              +                 +                           |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +              +                                                        +|  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X        X  X        X        X     X     X        X     X        X      |         17 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     M  +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     M  +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |       X                                         X                        |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               | X        X        X                 X  X  X        X        X            |             
      Hepatocellular Adenoma, Multiple     |       X              X  X  X  X  X              X        X     X  X      |             
      Leukemia Mononuclear                 |       X  X  X  X              X     X     X  X  X  X  X        X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +        +  +                          +                          +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +        +  +                          +                          +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +        +  +                          +                          +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +        +  +                          +                          +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +        +  +                          +                          M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +  +  +     +  +        +  +  +  +                       +  +|             
      Pars Distalis, Adenoma               |             X           X  X        X     X                          X   |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +  +  +                          +                          +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |             X  X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Liposarcoma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +        +  +                          +                          +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +        +  +        +     +  +        +  +  +  +              +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +        +  +     +                 +  +     +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |    X                    X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +        +  +                          +                          +|             
      Femoral, Leukemia Mononuclear        |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +  +                          +                          +|             
      Mandibular, Leukemia Mononuclear     |       X        X                             X                           |             
      Mediastinal, Leukemia Mononuclear    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X              X     X     X  X  X  X  X        X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  |       +        +  +                          I                          +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +        +                             M                    +     +|             
      Fibroadenoma                         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Skin                                    |       +        +  +                          +                          +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +        +  +                          +                          +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +           +                          +                          +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |       X                                                                 X|             
                                            __________________________________________________________________________|             
   Nose                                    |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +        +  +                          +                          +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                                   +            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +        +  +                          +                          +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +        +  +                          +                          +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X              X     X     X  X  X  X  X        X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3|            |
                                           | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                 +           +                 +     +     +  M      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |             X                             X        X     X  X            |          7 |
      Hepatocellular Carcinoma, Multiple   | X                                                                        |          1 |
      Hepatocellular Adenoma               |       X           X     X  X     X     X  X                              |         15 |
      Hepatocellular Adenoma, Multiple     |          X     X     X        X              X  X     X     X        X  X|         20 |
      Leukemia Mononuclear                 | X  X  X  X  X        X        X           X  X  X  X        X  X        X|         27 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                 +  +               |   4        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                 +           +                 +     +     +  +      |  12        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   1        |
      Carcinoma, Metastatic, Zymbal's Gland|                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +                 +           +                 +     +     +  +      |  12        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                 +           +                 +     +     +  +      |  12        |
      Leukemia Mononuclear                 |    X                                               X                     |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                 +           +                 +     +     +  +      |  12        |
      Leukemia Mononuclear                 |    X                                               X                     |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                 +           +                 +     +     +  +      |  12        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3|            |
                                           | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                 +           M                 +     +     +  +      |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +        +  +  +  +           +     +  +        +  +  +  +  +  +      |  27        |
      Pars Distalis, Adenoma               | X           X  X  X  X                                X                  |         12 |
      Pars Distalis, Leukemia Mononuclear  |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                 +           +                 +     +     +  +      |  13        |
      Leukemia Mononuclear                 |    X                                               X                     |          2 |
      C-Cell, Adenoma                      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
      Liposarcoma                          |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +                 +           +                 +     +     +  +     +|  13        |
      Adenoma                              |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +                 +     +     +                 +     +     +  +      |  20        |
      Leukemia Mononuclear                 |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +           +        +  +           +  +  +     +     +  +      |  20        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
      Polyp Stromal                        |                                                 X                        |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    I                 +           +                 +     +     +  +      |  11        |
      Femoral, Leukemia Mononuclear        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +           +           +                 +     +     +         |  12        |
      Mandibular, Leukemia Mononuclear     |    X     X           X                             X           X         |          8 |
      Mediastinal, Leukemia Mononuclear    |    X                                                           X         |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                                               +           +         |   3        |
      Leukemia Mononuclear                 |    X                                               X           X         |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X  X  X  X  X        X        X           X  X  X  X        X  X        X|         27 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +                 +           +                 +     M     +  +      |  10        |
      Leukemia Mononuclear                 |    X                                               X                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                 +           +                 +     +     +  +      |  11        |
      Fibroadenoma                         |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +                 +        +  +                 +  +  +     +  +      |  14        |
      Subcutaneous Tissue, Fibrosarcoma    |                               X                       X           X      |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3|            |
                                           | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                 +           +                 +     +     +  +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                 +           +                 +     +     +  +      |  11        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                          X               |          1 |
      Leukemia Mononuclear                 |    X                                               X           X         |          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                 +           +                 +     +     +  +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +     +                  |   5        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                  +                                       |   1        |
      Carcinoma                            |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +                 +           +                 +     +     +  +      |  12        |
      Leukemia Mononuclear                 |    X                                               X           X         |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +                 +           +  +              +     +     +  M      |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X  X  X        X        X           X  X  X  X        X  X        X|         27 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                      X                                                   |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     | X  X  X  X     X  X  X     X  X  X     X        X  X  X  X  X  X  X  X   |             
      Hepatocholangiocarcinoma             |                                                             X            |             
      Leukemia Mononuclear                 |             X     X           X              X  X                       X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |             X                                                            |             
      Pars Distalis, Adenoma, Mild         |                X                                                         |             
      Pars Distalis, Adenoma, Moderate     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Polyp Stromal                        |             X                    X                 X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                              X                          X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |                   X                          X                          X|             
      Mediastinal, Leukemia Mononuclear    |                                              X                           |             
      Pancreatic, Leukemia Mononuclear     |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X           X              X                          X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
      Fibroadenoma, Multiple               |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                X                                                         |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |                   X                          X                          X|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Clitoral Gland                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                 +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X           X              X  X                       X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7|            |
                                           | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                               X                             X        X   |          4 |
      Hepatocellular Adenoma               |                      X                                                   |          1 |
      Hepatocellular Adenoma, Multiple     | X     X  X     X  X     X  X     X  X  X     X  X  X     X  X  X  X  X   |         37 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 |    X     X        X     X     X  X     X  X  X  X  X  X  X     X     X  X|         22 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Squamous Cell Papilloma              |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                           X                              |          2 |
      Bilateral, Adenoma                   |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |                         X                                                |          2 |
      Pars Distalis, Adenoma, Mild         |                                                                          |          1 |
      Pars Distalis, Adenoma, Moderate     |             X                                                            |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7|            |
                                           | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Adenoma                      |          X                    X                                          |          2 |
      C-Cell, Carcinoma                    | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Carcinoma                            |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Polyp Stromal                        |       X        X                                X        X               |          7 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Femoral, Leukemia Mononuclear        |                                                                X         |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mandibular, Leukemia Mononuclear     |                   X  X  X     X        X  X        X  X  X     X         |         13 |
      Mediastinal, Leukemia Mononuclear    |    X                                   X  X                              |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                          +           +  +                          +   |   5        |
      Leukemia Mononuclear                 |                                        X  X                              |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    | +                          +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X        X  X  X     X  X     X  X  X     X  X  X     X     X  X|         21 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  I  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  41        |
      Leukemia Mononuclear                 |                               X           X                              |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Fibroadenoma                         |             X                                                            |          1 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7|            |
                                           | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                      X   |          1 |
      Leukemia Mononuclear                 |    X                 X        X        X  X        X  X        X     X  X|         13 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Clitoral Gland                  |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X        X  X  X     X  X     X  X  X  X  X  X  X     X     X  X|         23 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X     X  X                 X     X  X     X           X         |             
      Hepatocellular Carcinoma, Multiple   |                            X  X                       X                  |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     | X  X  X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X|             
      Leukemia Mononuclear                 |       X        X  X  X     X  X        X  X                    X  X  X  X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |             X                                         X  X  X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                         X|             
      C-Cell, Adenoma                      |          X           X        X           X              X           X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X              X                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                         X|             
      Leiomyosarcoma                       |                                                                          |             
      Polyp Stromal                        |    X              X                                                     X|             
      Sarcoma Stromal                      |                                           X                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Polyp                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                X              X                                X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |                X              X        X  X                    X     X   |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                     X                                    |             
      Mediastinal, Leukemia Mononuclear    |                X                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X        X  X        X  X                    X  X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
      Fibroadenoma                         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Lipoma          |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X        X              X        X  X                    X  X      |             
      Squamous Cell Carcinoma, Multiple,   |                                                                          |             
           Metastatic, Uncertain Primary   |                                                                          |             
          Site                             |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                 +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X              X                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Papilloma                            |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X     X  X        X  X                    X  X  X  X|             
      Lymphoma Malignant Histiocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3|            |
                                           | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |          X     X                    X  X           X           X  X     X|         16 |
      Hepatocellular Carcinoma, Multiple   |                                              X        X  X               |          6 |
      Hepatocellular Adenoma               |                            X                                             |          1 |
      Hepatocellular Adenoma, Multiple     | X  X  X  X  X  X  X     X     X  X  X  X  X  X  X     X  X  X  X  X  X  X|         44 |
      Leukemia Mononuclear                 |                   X  X  X           X     X     X  X  X  X     X  X  X   |         24 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                           X                              |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                    X                     |          1 |
      Leukemia Mononuclear                 |    X                 X                    X                              |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Leukemia Mononuclear                 |    X                 X                    X                              |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |                                                 X                        |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3|            |
                                           | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |                                                    X                     |          7 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Carcinoma                            |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leiomyosarcoma                       |    X                                                                     |          1 |
      Polyp Stromal                        |                               X                                          |          4 |
      Sarcoma Stromal                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                                 +   |   2        |
      Leiomyosarcoma                       |    X                                                                     |          1 |
      Polyp                                |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Femoral, Leukemia Mononuclear        |                      X                    X     X                        |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mandibular, Leukemia Mononuclear     |                   X                             X        X     X  X  X   |         12 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X              X  X  X           X     X     X  X  X  X     X  X  X   |         24 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |    X                             X                 X                     |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3|            |
                                           | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X              X     X     X  X  X  X               |         14 |
      Squamous Cell Carcinoma, Multiple,   |                                                                          |            |
           Metastatic, Uncertain Primary   |                                                                          |            |
          Site                             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +     +                                               +      |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                           X                              |          3 |
      Transitional Epithelium, Carcinoma   |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X              X  X  X           X     X     X  X  X  X     X  X  X   |         25 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|             
                                           | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Adenoma               |                                                                         X|             
      Leukemia Mononuclear                 | X           X              X  X  X  X  X  X     X     X     X  X         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Acinus, Adenoma                      |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X              X        X           X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukemia Mononuclear                 |       X     X              X        X           X                        |             
      Pheochromocytoma Malignant           |                            X                                             |             
      Pheochromocytoma Benign              |       X                    X                    X                        |             
      Bilateral, Pheochromocytoma Benign   |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                         |             
      Carcinoma                            |    X                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X           X  X     X  X                          X  X               |             
      Pars Distalis, Leukemia Mononuclear  |       X                       X     X                 X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|             
                                           | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                                                             X            |             
      C-Cell, Adenoma                      |       X  X        X     X        X        X  X        X  X     X         |             
      C-Cell, Carcinoma                    |                                                          X               |             
      Follicular Cell, Adenoma             |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                  X                                       |             
      Serosa, Mesothelioma Benign          |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Carcinoma                            |                                           X                    X         |             
      Duct, Squamous Cell Papilloma        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X     X  X  X  X  X  X  X  X  X     X  X     X  X  X  X     X|             
      Interstitial Cell, Adenoma           |          X     X                             X                       X   |             
      Tunic, Mesothelioma Benign           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                            X  X     X           X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Leukemia Mononuclear       |                                     X                          X         |             
      Mandibular, Leukemia Mononuclear     |       X                    X  X  X  X     X           X                  |             
      Mediastinal, Leukemia Mononuclear    |                                  X  X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                      +   |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X     X     X        X  X  X  X  X  X     X     X  X  X  X         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                               X     X                 X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|             
                                           | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                X                       X     X                           |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Leukemia Mononuclear                 |       X     X              X  X  X  X           X     X        X         |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
      Carcinoma                            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                             X                    X               |             
      Medulla, Sarcoma                     |                                           X                              |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X     X     X        X  X  X  X  X  X     X     X  X  X  X         |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7|            |
                                           | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma                       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                         X|          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X     X                                   X  X  X  X  X  X     X   |         22 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Schwannoma Malignant                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X     X                                   X  X                 X   |         10 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |       X     X                                   X  X                 X   |         10 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |    X     X     X        X        X                 X           X     X   |         11 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Adenoma                              |                X     X                                         X         |          4 |
      Carcinoma                            |                               X  X                                       |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7|            |
                                           | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |                X                 X     X  X        X                 X   |         13 |
      Pars Distalis, Leukemia Mononuclear  |       X                                                  X               |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |    X           X           X     X     X        X                        |         16 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Serosa, Mesothelioma Benign          |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenoma                              |                         X  X                                   X         |          4 |
      Carcinoma                            |                                                 X                        |          3 |
      Duct, Squamous Cell Papilloma        |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X     X  X  X|         43 |
      Interstitial Cell, Adenoma           |                                  X                             X         |          6 |
      Tunic, Mesothelioma Benign           |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Leukemia Mononuclear        |             X                                   X     X                  |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Leukemia Mononuclear       |                                                                          |          2 |
      Mandibular, Leukemia Mononuclear     |    X  X     X                                   X  X  X     X  X     X   |         16 |
      Mediastinal, Leukemia Mononuclear    |                                                                      X   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                         +|   2        |
      Fibrosarcoma, Metastatic, Skin       |                                                                         X|          1 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7|            |
                                           | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X  X     X                                   X  X  X  X  X  X     X   |         25 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +     +  +        +  +  +  +  +  +  +  +  +     +  +  +     +   |  39        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      | X                 X                                                      |          2 |
      Squamous Cell Papilloma              |                                                                   X      |          1 |
      Subcutaneous Tissue, Fibroma         |                                                 X        X               |          5 |
      Subcutaneous Tissue, Fibroma,        |                                                                          |            |
          Multiple                         |                                              X                           |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                        X                                X|          2 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                      +                 +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                 +                                 |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                            X                                             |          2 |
      Leukemia Mononuclear                 |       X     X                                      X  X  X           X   |         15 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7|            |
                                           | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X              X   |          5 |
      Medulla, Sarcoma                     |                                                                          |          1 |
      Renal Tubule, Carcinoma              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X     X                                   X  X  X  X  X  X     X   |         25 |
      Mesothelioma Benign                  |                                  X                                       |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|             
                                           | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +     +        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +     +        +  +           +  +           +  +        +   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +     +        +  +           +  +           +  +        +   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +     +        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                            X                                             |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +     M        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                            X                                             |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +     +        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                            X                                             |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Prostate |                                                          X               |             
      Hepatocellular Adenoma               | X                    X                                                   |             
      Hepatocellular Adenoma, Multiple     |                                        X                                 |             
      Leukemia Mononuclear                 | X  X           X     X  X  X        X  X     X  X  X  X     X  X  X  X  X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                       +                    +               |             
      Adenocarcinoma, Metastatic, Prostate |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |             X                       X                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +     +        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Mesothelioma Malignant               |                                                                          |             
      Squamous Cell Papilloma              |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoid Tumor Malignant            |       X                                                                  |             
      Leukemia Mononuclear                 |                            X                                             |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|             
                                           | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +     +        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Epicardium, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +     +        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Complex             |             X                                                            |             
      Pheochromocytoma Benign              |                                                             X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +     +        +  +           +  +           +  +        +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +     +        +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +     +        +  +           +  +  +        +  +  +     +   |             
      Pars Distalis, Adenoma               |       X     X     X                             X                        |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Nervosa, Astrocytoma Malignant, |                                                                          |             
           Metastatic, Brain               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +     +        +  +  +        +  +           +  +        +   |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                                                                      X   |             
      C-Cell, Carcinoma                    |                                  X                       X               |             
      Follicular Cell, Carcinoma           |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Chordoma                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                   +        +  +           +  +           +  +        +   |             
      Adenocarcinoma, Metastatic, Prostate |                                                          X               |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +     +     +        +  +           +  +     +     +  +        +   |             
      Adenoma                              |       X                                                                  |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |             +     +        +  +           +  +           +  +        +   |             
      Adenocarcinoma                       |                                                          X               |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|             
                                           | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X     X  X  X  X        X  X     X  X     X  X|             
      Interstitial Cell, Adenoma           |                               X              X                    X      |             
      Tunic, Mesothelioma Malignant        |                                                    X                     |             
      Tunic, Mesothelioma Malignant,       |                                                                          |             
          Metastatic                       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +     +        +  +           +  +           +  +        +   |             
      Femoral, Leukemia Mononuclear        |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +        +  +           +  +           +  +        +   |             
      Mandibular, Leukemia Mononuclear     |                                                                      X   |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                           X                              |             
      Mediastinal, Adenocarcinoma,         |                                                                          |             
          Metastatic, Prostate             |                                                          X               |             
      Mediastinal, Leukemia Mononuclear    |                                                                      X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                          +               |             
      Adenocarcinoma, Metastatic, Prostate |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X     X  X  X     X  X  X     X  X  X  X     X  X  X  X  X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +     +        +  M           +  +           I  M        +   |             
      Leukemia Mononuclear                 |                            X                                             |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +              +  +              +           +  +        +   |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +  +        +  +        +  +  +           +  +     +  +   |             
      Subcutaneous Tissue, Fibroma         |                                                                   X      |             
      Subcutaneous Tissue, Fibrosarcoma    |                X                       X     X                           |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Histiocytic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +     +        +  +           +  +           +  +        +   |             
      Rib, Osteosarcoma                    |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|             
                                           | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +     +        +  +           +  +           +  +        +   |             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +     +        +  +           +  +           +  +        +   |             
      Adenocarcinoma, Metastatic, Prostate |                                                          X               |             
      Leukemia Mononuclear                 |                            X                                X        X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +     +        +  +           +  +           +  +        +   |             
      Submucosa, Glands, Adenocarcinoma    |                               X                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +     +        +  +           +  +           +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +     +  +     +  +           +  +           +  +        +   |             
      Leukemia Mononuclear                 |                            X                                         X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +     +        +  +           +  +           +  +        +   |             
      Adenocarcinoma, Metastatic, Prostate |                                                          X               |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X           X     X  X  X     X  X  X     X  X  X  X     X  X  X  X  X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
      Mesothelioma Malignant               |             X                       X              X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +  +  +  +     +           +  +  +     +              A     +|  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Mesothelioma Malignant               |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Mesothelioma Malignant               |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        +  +  +  +     +           +  +  +     +              A     +|  19        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        +  +  +  +     +           +  +  +     +              A     +|  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Prostate |                                                                          |          1 |
      Hepatocellular Adenoma               |                               X  X                                       |          4 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X  X  X  X        X  X  X  X  X  X  X     X                 X|         31 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +  +           +                              |   6        |
      Adenocarcinoma, Metastatic, Prostate |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Mesothelioma Malignant               |                            X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Leukemia Mononuclear                 |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                            X                                             |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoid Tumor Malignant            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Mesothelioma Malignant               |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Leukemia Mononuclear                 |                X                          X                              |          2 |
      Epicardium, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +        +  +  +  +     +     +     +  +  +     +              +     +|  22        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +        +  +  +  +     +     +     +  +  +     +              +     +|  21        |
      Leukemia Mononuclear                 |                X  X  X           X     X                                 |          5 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +        +  +  +  +     +     +     +  +  +     +              +     +|  22        |
      Leukemia Mononuclear                 |                X  X  X           X     X                                 |          5 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |             X                    X           X                           |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Adenoma                              |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M        +  +  +  +     +           +  +  +     +  +  +        +  +  +|  27        |
      Pars Distalis, Adenoma               | X                                                     X              X   |          7 |
      Pars Distalis, Leukemia Mononuclear  |                X     X                    X                              |          3 |
      Pars Nervosa, Astrocytoma Malignant, |                                                                          |            |
           Metastatic, Brain               |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +  +  +  +     +           +  +  +     +  +           A  +  +|  23        |
      Bilateral, C-Cell, Adenoma           |                                        X                                 |          1 |
      C-Cell, Adenoma                      |                      X                                               X   |          3 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
      Follicular Cell, Carcinoma           |                                                       X                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                         +|   1        |
      Chordoma                             |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +        +  +  +  +     +           +  +  +     +              +     +|  20        |
      Adenocarcinoma, Metastatic, Prostate |                                                                          |          1 |
      Serosa, Mesothelioma Malignant       |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +        +  +  +  +     +  +  +     +  +  +     +              +     +|  25        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |             X        X           X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +                                                  +      |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X     X  X  X  X  X  X  X  X  X  X  X     X  X  X  X     X  X|         41 |
      Interstitial Cell, Adenoma           |    X                                                              X      |          5 |
      Tunic, Mesothelioma Malignant        |    X                       X                                             |          3 |
      Tunic, Mesothelioma Malignant,       |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Femoral, Leukemia Mononuclear        |                X  X                       X                              |          3 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +  +  +     +     +     +  +  +     +     +        +     +|  23        |
      Mandibular, Leukemia Mononuclear     |                X  X  X           X        X                              |          6 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Prostate             |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                X                          X                              |          3 |
      Pancreatic, Leukemia Mononuclear     |                X                                                         |          1 |
      Renal, Leukemia Mononuclear          |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                  +                       +               |   3        |
      Adenocarcinoma, Metastatic, Prostate |                                                                          |          1 |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X     X  X  X  X        X  X  X  X  X  X  X     X                 X|         31 |
      Mesothelioma Malignant               |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +  +  +  M     +           +  +  +     +              +     +|  17        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                X                          X                              |          3 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +        +     +  +     +           +  +                              |  14        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +  +  +  +     +           +  +  +     +     +        +     +|  26        |
      Subcutaneous Tissue, Fibroma         |          X                                                               |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                          X               |          4 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Histiocytic            |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Rib, Osteosarcoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Astrocytoma Malignant                |                                              X                           |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Adenocarcinoma, Metastatic, Prostate |                                                                          |          1 |
      Leukemia Mononuclear                 |                X  X  X                 X  X                              |          8 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Submucosa, Glands, Adenocarcinoma    |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  64                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +  +  +     +           +  +  +     +        +     +  +  +|  24        |
      Leukemia Mononuclear                 |                X                          X                              |          4 |
      Renal Tubule, Adenoma                |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +        +  +  +  +     +           +  +  +     M              +     +|  20        |
      Adenocarcinoma, Metastatic, Prostate |                                                                          |          1 |
      Mesothelioma Malignant               |                            X                                             |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X     X  X  X  X        X  X  X  X  X  X  X     X                 X|         32 |
      Lymphoma Malignant Histiocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Mesothelioma Malignant               |    X                       X                                             |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  65                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|             
                                           | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                  X                                       |             
      Hepatocellular Adenoma               |                                                       X                  |             
      Hepatocellular Adenoma, Multiple     |                               X                                          |             
      Leukemia Mononuclear                 |          X     X  X     X  X  X  X  X              X  X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +                 +  +  +                             +           +      |             
      Leukemia Mononuclear                 |                                                       X                  |             
      Acinus, Adenoma                      |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                 +  +  +                             +           +      |             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +                 +  +  +                             +           +      |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +                 +  +  +                             +           +      |             
      Leukemia Mononuclear                 |                                                       X                  |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +  +  +  +                          +     +     +      |             
      Pars Distalis, Adenoma               |       X              X  X  X                                X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                 +  +  +                             +           +      |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|             
                                           | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                 +  +  +     +                 +     +        +  +      |             
      Adenoma                              |                               X                                          |             
      Carcinoma                            |                                                 X                 X      |             
                                            __________________________________________________________________________|             
   Prostate                                | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                         +           +                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X  X  X  X   |             
      Interstitial Cell, Adenoma           |                               X                                         X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +                 +  +  +                             +           +      |             
      Femoral, Leukemia Mononuclear        |                   X                                               X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +  +  +     +                       +           +      |             
      Mandibular, Leukemia Mononuclear     |                   X     X     X                       X           X      |             
      Mediastinal, Leukemia Mononuclear    |                               X                       X                  |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X     X  X  X  X  X              X  X  X     X  X  X  X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M                 +  +  +                             +           +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                 +  +  +              +           +  +           +      |             
      Fibroadenoma                         |                                        X           X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +           +  +  +     +        +              +     +  +  +      |             
      Keratoacanthoma                      |                                                             X            |             
      Sebaceous Gland, Adenoma             |                                                                X         |             
      Subcutaneous Tissue, Fibroma         |                         X     X                                X         |             
      Subcutaneous Tissue, Fibrosarcoma    | X     X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                 +  +  +                             +           +      |             
      Femur, Osteosarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|             
                                           | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                 +  +  +  +                          +           +      |             
      Alveolar/Bronchiolar Adenoma         |                            X                                      X      |             
      Alveolar/Bronchiolar Carcinoma       | X                                                                        |             
      Chordoma, Metastatic, Uncertain      |                                                                          |             
          Primary Site                     |                                                       X                  |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Leukemia Mononuclear                 |                   X     X                             X                  |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Pheochromocytoma Complex, Metastatic,|                                                                          |             
           Adrenal Gland                   |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                 +  +  +                             +           +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +  +  +  +     +                       +     +     +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +                 +  +  +                             +           +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X  X     X  X  X  X  X              X  X  X     X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               | X                                                                 X      |          3 |
      Hepatocellular Adenoma, Multiple     |       X                                                                  |          2 |
      Leukemia Mononuclear                 | X  X  X  X     X  X  X  X  X  X  X        X  X     X              X      |         30 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +           +     +  +           +  +  +  +                        |  15        |
      Leukemia Mononuclear                 |       X                                   X                              |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Leukemia Mononuclear                 |       X                                   X                              |          3 |
      Pheochromocytoma Complex             |                                                             X            |          1 |
      Pheochromocytoma Benign              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +     +  +     +     +  +  +  +           +            |  22        |
      Pars Distalis, Adenoma               | X              X           X     X                                       |          9 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +           +     +  +           +  +  +  +           +           +|  17        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |    X                    X  X              X                              |          4 |
      C-Cell, Carcinoma                    |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +           +     +  +           +  +  +  +     +     +            |  20        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                        X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                +         |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X     X     X  X  X  X|         43 |
      Interstitial Cell, Adenoma           |                                                 X     X                  |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +           +     +  +           +  +  +  M           +            |  15        |
      Femoral, Leukemia Mononuclear        |                                              X                           |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +           +     +  +           +  +  +  +           +            |  18        |
      Mandibular, Leukemia Mononuclear     |    X  X           X                       X  X                           |         10 |
      Mediastinal, Leukemia Mononuclear    |    X              X                                                      |          4 |
      Pancreatic, Leukemia Mononuclear     |                   X                                                      |          1 |
      Renal, Leukemia Mononuclear          | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   2        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosarcoma                         |                                                                      X   |          1 |
      Leukemia Mononuclear                 | X  X  X  X     X  X  X  X  X  X  X        X  X     X     X        X  X   |         32 |
      Osteosarcoma, Metastatic, Bone       |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +           +     +  +           +  +  +  +           +            |  15        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +           +        +              +                 +            |  14        |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +           +  +  +  +           +  +  +  +           +            |  22        |
      Keratoacanthoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                      X     X              X                              |          6 |
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Femur, Osteosarcoma                  |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +           +     +  +           +  +  +  +           +            |  17        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Chordoma, Metastatic, Uncertain      |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                         X                                                |          1 |
      Leukemia Mononuclear                 |    X  X           X        X              X  X                           |          9 |
      Osteosarcoma, Metastatic, Bone       |                                                 X                        |          1 |
      Pheochromocytoma Complex, Metastatic,|                                                                          |            |
           Adrenal Gland                   |                                                             X            |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +           +     +  +           +  +  +  +           +            |  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +        +                                               +      |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +           +     +  +           +  +  +  +           +            |  20        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +           +     +  +           +  +  +  +           +  +         |  17        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X  X     X  X  X  X  X  X  X        X  X     X     X        X  X   |         32 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|             
                                           | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +  +     +  +  +        +  +              +           +      |             
      Adenocarcinoma                       |                                                                   X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +  +     +  +  +        +  +                          +      |             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Intestine Small                  |                                                                   X      |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                         X     X                                      X   |             
      Hepatocellular Adenoma, Multiple     | X              X                                         X               |             
      Leukemia Mononuclear                 | X  X        X  X     X  X  X  X  X  X        X  X  X  X  X     X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +  +     +  +  +        +  +              +           +      |             
      Leukemia Mononuclear                 |                            X                                             |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                            X                                             |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Squamous Cell Carcinoma     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +  +     +  +  +        +  +              +           +      |             
      Leukemia Mononuclear                 |             X              X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +  +     +  +  +        +  +              +           +      |             
      Leukemia Mononuclear                 |             X  X           X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +  +     +  +  +        +  +              +           +      |             
      Leukemia Mononuclear                 |             X  X           X                                             |             
      Pheochromocytoma Malignant           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|             
                                           | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +  +     +  +  +        +  +              +           +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     +  +     +  +  +        +  +              +           +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +     +  +  +     +  +  +     +        +        +  +      |             
      Pars Distalis, Adenoma               |    X           X        X              X     X        X        X         |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                            X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +  +     +  +  +        +  +              +           +      |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |       X        X                                      X                  |             
      Follicular Cell, Adenoma             |                X                                                         |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +     +  +     +  +  +        +  +              +           +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +     +  +  +  +  +  +        +  +  +     +     +        +  M      |             
      Carcinoma                            |                                     X  X  X     X                        |             
                                            __________________________________________________________________________|             
   Prostate                                |       +     +  +     +  +  +        +  +              +           +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X|             
      Interstitial Cell, Adenoma           |                                        X                                 |             
      Tunic, Mesothelioma Malignant        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +  +     +  +  +        +  +              +           +      |             
      Femoral, Leukemia Mononuclear        |                      X     X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +     +  +  +        +  +              +           +      |             
      Mandibular, Leukemia Mononuclear     |                X     X  X  X                                             |             
      Mediastinal, Leukemia Mononuclear    |                X           X                                             |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                    +                                      +      |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X  X     X  X  X  X  X  X        X  X  X  X  X     X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|             
                                           | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       M     +  +     +  +  +        M  +              +           M      |             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +     +  +  +        +  M              +                 +|             
      Fibroadenoma                         |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +  +  +  +  +  +        +  +     +        +     +     +      |             
      Fibroma                              |                                              X                           |             
      Trichoepithelioma                    |                                                             X            |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
      Subcutaneous Tissue, Fibrosarcoma    |       X                                                                  |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +  +     +  +  +        +  +              +           +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +  +     +  +  +        +  +  +           +           +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +     +  +     +  +  +        +  +              +           +      |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                     X                                    |             
      Leukemia Mononuclear                 |             X  X     X     X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +     +  +     +  +  +        +  +              +           +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +     +     +        +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +     +  +  +        +  +              +           +      |             
      Leukemia Mononuclear                 |             X  X           X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +  +     +  +  +        +  +              +           +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X  X     X  X  X  X  X  X        X  X  X  X  X     X        X|             
      Mesothelioma Malignant               |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6|            |
                             DAY ON TEST   | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7|            |
                                           | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  A        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  28        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
      Adenocarcinoma                       |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Intestine Small                  |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                              X                          X|          2 |
      Hepatocellular Adenoma               |                                        X                                 |          4 |
      Hepatocellular Adenoma, Multiple     |    X                 X           X                                       |          6 |
      Leukemia Mononuclear                 | X  X  X        X  X  X     X  X  X  X        X        X     X  X     X   |         32 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                        +   |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
      Leukemia Mononuclear                 |                                                                X         |          2 |
      Acinus, Adenoma                      |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   1        |
      Gingiva, Squamous Cell Carcinoma     |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
      Leukemia Mononuclear                 |                               X                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +     +  +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  29        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  75                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6|            |
                             DAY ON TEST   | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7|            |
                                           | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +     +  +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  28        |
      Leukemia Mononuclear                 | X     X                    X  X              X              X  X         |         10 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +     +  +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  29        |
      Leukemia Mononuclear                 | X     X                    X  X              X              X  X         |         10 |
      Pheochromocytoma Malignant           |                X                                                         |          1 |
      Pheochromocytoma Benign              |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
      Adenoma                              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
      Adenoma                              |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +        +  +  +  +  +  +  +     I  +  +  +  +     +  +  +     +|  32        |
      Pars Distalis, Adenoma               |                         X  X        X                                   X|         11 |
      Pars Distalis, Adenoma, Multiple     |                                                    X                     |          1 |
      Pars Distalis, Leukemia Mononuclear  |       X                                                        X         |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +        +  +     +  +  +  +     M  +  +  +  +  +  +  +  +     +|  28        |
      Bilateral, C-Cell, Adenoma           |                                                       X                  |          1 |
      C-Cell, Adenoma                      |                      X     X  X     X                                   X|          8 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  28        |
      Leukemia Mononuclear                 |                               X                                          |          1 |
      Serosa, Mesothelioma Malignant       |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  +  +     +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  32        |
      Carcinoma                            |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  28        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X     X     X  X  X   |         45 |
      Interstitial Cell, Adenoma           |                                                       X     X           X|          4 |
      Tunic, Mesothelioma Malignant        |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
      Femoral, Leukemia Mononuclear        | X                 X  X        X              X                           |          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  76                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6|            |
                             DAY ON TEST   | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7|            |
                                           | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
      Mandibular, Leukemia Mononuclear     | X     X           X  X     X  X  X  X        X        X     X  X         |         16 |
      Mediastinal, Leukemia Mononuclear    |                   X           X     X        X        X     X  X         |          9 |
      Pancreatic, Leukemia Mononuclear     |                            X                 X                           |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                 +              +  +        +                          +|   9        |
      Leukemia Mononuclear                 | X                 X              X  X        X                           |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X  X  X     X  X  X  X     X  X  X  X        X        X     X  X     X   |         33 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +        +  +     I  +  +  +     M  M  +  +  +     +  +  +     +|  22        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                 +  +  +  +  +  +  +           +  +  +     +  +  +     +|  23        |
      Fibroadenoma                         |                         X                       X  X                     |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  31        |
      Fibroma                              |                                                                          |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                   X      |          2 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  28        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  29        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +        +  +     +  +  +  +  +  M  +  +  +  +     +  +  +     +|  28        |
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X           X  X     X  X  X  X        X        X     X  X         |         16 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  77                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6|            |
                             DAY ON TEST   | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7|            |
                                           | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                             +              +|   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +        +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  32        |
      Leukemia Mononuclear                 |                               X                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X     X  X  X  X     X  X  X  X        X        X     X  X     X   |         33 |
      Mesothelioma Malignant               |                            X                                             |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  78                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|             
                                           | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +  +  M     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +  +  M     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +  +  A     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                          X               |             
      Hepatocellular Adenoma               |                      X                    X        X  X     X           X|             
      Hepatocellular Adenoma, Multiple     |             X                                                            |             
      Leukemia Mononuclear                 | X  X  X  X  X  X              X     X     X  X  X  X  X  X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |    X  X                                                                  |             
      Acinus, Adenoma                      |                X        X                                            X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        M  +  +     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
      Squamous Cell Carcinoma              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                                           X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |                               X                                X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |                               X                                X         |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|             
                                           | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Pars Distalis, Adenoma               |             X              X     X           X                 X     X   |             
      Pars Distalis, Leukemia Mononuclear  |    X                          X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                  X                                       |             
      Follicular Cell, Adenoma             |                            X                                      X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +        +  +  +     +  +  +              +              +  +  +  +   |             
      Serosa, Mesothelioma Malignant       |             X                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Adenoma                              |                                                                          |             
      Carcinoma                            | X              X                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X  X  X  X        X  X  X  X  X  X  X  X  X  X     X  X  X  X|             
      Interstitial Cell, Adenoma           |    X                    X                                   X            |             
      Tunic, Mesothelioma Malignant        |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Femoral, Leukemia Mononuclear        |    X                          X                             X  X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  M  +  +     +  +  +  +           +              +  +  +  +   |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mandibular, Leukemia Mononuclear     |    X                          X              X              X  X  X  X   |             
      Mediastinal, Fibrosarcoma,           |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |    X                          X              X                 X         |             
      Pancreatic, Leukemia Mononuclear     |                               X                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +                       +           +                 +         |             
      Leukemia Mononuclear                 |    X     X                                   X                 X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                                  +                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X              X     X     X  X  X  X  X  X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +        +  +  +     +  M  +  +           +              +  +  M  I   |             
      Leukemia Mononuclear                 |    X                                         X                 X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|             
                                           | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +  +        +  +  +           +              +        +   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         |                         X     X  X                                X      |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Glioma Malignant                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma Adenosquamous              |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Leukemia Mononuclear                 |    X                          X              X              X  X  X      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Peritracheal Tissue, Fibrosarcoma,   |                                                                          |             
           Metastatic, Skin                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +              +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                         X                 X         |             
      Renal Tubule, Adenoma                |                            X                                         X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X              X     X     X  X  X  X  X  X  X  X  X  X  X|             
      Mesothelioma Malignant               |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9|            |
                                           | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +           +        +  +  A  +  +        +  +  +  +  +  +  +  +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          6 |
      Hepatocellular Adenoma, Multiple     | X           X     X  X                    X  X                           |          7 |
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X  X     X  X  X  X  X|         41 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
      Leukemia Mononuclear                 |                         X                                                |          3 |
      Acinus, Adenoma                      |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Leukemia Mononuclear                 |                         X     X                    X                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +           +     +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +           +     M  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Leukemia Mononuclear                 |                         X     X              X     X                 X   |          7 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +           +     +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  82                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9|            |
                                           | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                         X     X              X     X                 X   |          7 |
      Pheochromocytoma Malignant           |                      X                                                   |          1 |
      Pheochromocytoma Benign              |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Adenoma                              | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +           +        +  +  +  +  +        +  +  +  +  I  +  +  +  +  +|  30        |
      Pars Distalis, Adenoma               |                                     X                 X           X      |          9 |
      Pars Distalis, Leukemia Mononuclear  |                         X                    X                           |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      C-Cell, Adenoma                      | X                                            X                       X   |          3 |
      C-Cell, Carcinoma                    |                            X     X                                       |          3 |
      Follicular Cell, Adenoma             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +     +  +     +  M  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  34        |
      Adenoma                              |             X                                                            |          1 |
      Carcinoma                            |       X                                               X                  |          4 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +           +        +  +  +  +  +        +  +  +  +  +  M  +  +  +  +|  30        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X  X  X  X              X  X  X  X     X  X           X  X  X|         37 |
      Interstitial Cell, Adenoma           |    X                          X                 X        X  X  X         |          9 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Femoral, Leukemia Mononuclear        |                                  X                                   X   |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +     +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  33        |
      Deep Cervical, Leukemia Mononuclear  |                         X                                                |          1 |
      Mandibular, Leukemia Mononuclear     | X  X                    X     X  X  X              X        X  X  X  X  X|         19 |
      Mediastinal, Fibrosarcoma,           |                                                                          |            |
          Metastatic, Skin                 |                                                          X               |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  83                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9|            |
                                           | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear    |       X              X  X        X           X                 X     X   |         11 |
      Pancreatic, Leukemia Mononuclear     |                                  X                             X         |          3 |
      Renal, Leukemia Mononuclear          |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +        +                                      +         |   8        |
      Leukemia Mononuclear                 |                X        X                                      X         |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X  X     X  X  X  X  X|         41 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M           +     +  +  M  +  +  +        +  +  +  +  +  M  +  +  M  M|  24        |
      Leukemia Mononuclear                 |                      X  X     X                                X         |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                    +  +                    +  +     +  +  +  +  +   |  20        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          4 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Glioma Malignant                     |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
      Alveolar/Bronchiolar Carcinoma       |                                                                      X   |          1 |
      Carcinoma Adenosquamous              |          X                                                               |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                          X               |          1 |
      Leukemia Mononuclear                 | X  X                    X     X  X  X        X     X        X  X     X   |         17 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Peritracheal Tissue, Fibrosarcoma,   |                                                                          |            |
           Metastatic, Skin                |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +              +      |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  84                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9|            |
                                           | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
      Leukemia Mononuclear                 |                         X     X  X                             X         |          7 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X  X     X  X  X  X  X|         41 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  85                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|             
                                           | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               | X  X  X  X           X                                X                  |             
      Hepatocellular Adenoma, Multiple     |             X                          X     X                           |             
      Leukemia Mononuclear                 |    X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X        X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Lipoma                               | X                                                                        |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +  +  +     +        +  +     +  +           +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |          X                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +           +  +  +     +        +  +     +  M           +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Leukemia Mononuclear                 |    X           X           X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Leukemia Mononuclear                 |    X           X           X                                             |             
      Pheochromocytoma Malignant           |                                                 X                        |             
      Pheochromocytoma Benign              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M           +  +  +     +        +  +     M  +           +  +  +  +   |             
      Adenoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +           +  +  +     +  +     +  +     +  +     +     +  +  +  +   |             
      Pars Distalis, Adenoma               |                      X     X  X              X              X        X   |             
      Pars Distalis, Leukemia Mononuclear  |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|             
                                           | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Bilateral, Follicular Cell, Adenoma  |                                                                          |             
      C-Cell, Adenoma                      |                                                             X     X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Serosa, Mesothelioma Benign          |                                                                          |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +  +  +     +  +     +  +     +  +           +  +  +  +   |             
      Carcinoma                            |                   X                                                  X   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X     X  X|             
      Interstitial Cell, Adenoma           | X                                            X                           |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Femoral, Leukemia Mononuclear        |                   X                    X     X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +  +     +     +  +  +     +  M           +  +  +  +   |             
      Mandibular, Leukemia Mononuclear     |    X           X  X  X     X           X     X                           |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Mediastinal, Leukemia Mononuclear    |    X           X                       X     X                           |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Pancreatic, Leukemia Mononuclear     |    X                                                                     |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +                 +  +                          +         |             
      Leukemia Mononuclear                 |                X                 X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                                     +                          +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X        X  X|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           +  +  +     M        +  +     +  +           +  +  +  +   |             
      Leukemia Mononuclear                 |    X           X                                            X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|             
                                           | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           +     +     +        +  +     +                       +   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +  +  +     +        +  +  +  +  +           +  +  +  +   |             
      Basosquamous Tumor Benign            |                                           X                              |             
      Subcutaneous Tissue, Fibroma         |                                                                X         |             
      Subcutaneous Tissue, Fibrosarcoma    |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Femur, Hemangiosarcoma               |                                                                          |             
      Lumbar, Osteosarcoma                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma Adenosquamous              |                                                                          |             
      Leukemia Mononuclear                 |    X           X  X                    X     X  X                        |             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +           +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X        X  X|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7|            |
                                           | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                   X                                                      |          1 |
      Hepatocellular Adenoma               |                               X  X     X        X                        |         10 |
      Hepatocellular Adenoma, Multiple     |                   X                                               X  X   |          6 |
      Leukemia Mononuclear                 |       X        X  X     X  X  X        X  X  X  X  X  X  X  X     X  X  X|         37 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   2        |
      Lipoma                               |                                                                          |          1 |
      Mesothelioma Malignant               |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Leukemia Mononuclear                 |                                                             X     X      |          2 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Leukemia Mononuclear                 |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Leukemia Mononuclear                 |                                                             X     X  X   |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +        M     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +        M     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Leukemia Mononuclear                 |                            X           X              X     X     X  X   |          9 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +        M     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Leukemia Mononuclear                 |                            X           X              X     X     X  X   |          9 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                        X     X                           |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  89                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7|            |
                                           | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  29        |
      Adenoma                              |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +        +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  34        |
      Pars Distalis, Adenoma               |                      X  X        X  X        X                           |         11 |
      Pars Distalis, Leukemia Mononuclear  |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Bilateral, Follicular Cell, Adenoma  |                                                 X                        |          1 |
      C-Cell, Adenoma                      |                            X  X        X     X  X                 X      |          8 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +        +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Serosa, Mesothelioma Benign          |                               X                                          |          1 |
      Serosa, Mesothelioma Malignant       |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  32        |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X     X     X  X  X  X  X  X  X     X  X     X  X  X     X  X|         42 |
      Interstitial Cell, Adenoma           |                      X                       X                    X      |          5 |
      Tunic, Mesothelioma Malignant        |                               X  X                 X                     |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Femoral, Leukemia Mononuclear        |                            X              X        X              X  X   |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +        M     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Mandibular, Leukemia Mononuclear     |                         X  X  X        X  X  X  X  X  X  X  X     X  X  X|         21 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                               X           X  X  X  X     X           X   |         11 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                           X                              |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  90                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7|            |
                                           | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   4        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X        X  X     X  X  X        X  X  X  X  X  X  X  X     X  X  X|         37 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +        +     +  M  +  +  M     +  M  +  +  +  +  +  +     +  +  +|  27        |
      Leukemia Mononuclear                 |                X              X        X              X     X     X  X   |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +     +     +  +  +     +           +     +  M     +  +  M|  18        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  32        |
      Basosquamous Tumor Benign            |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                   X      |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Femur, Hemangiosarcoma               |                               X                                          |          1 |
      Lumbar, Osteosarcoma                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +        +     +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +|  31        |
      Alveolar/Bronchiolar Adenoma         |                                                                   X      |          1 |
      Carcinoma Adenosquamous              |                                                                X         |          1 |
      Leukemia Mononuclear                 |                X           X  X        X  X  X     X  X  X  X     X  X  X|         19 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +     +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  37        |
      Leukemia Mononuclear                 |                X                                            X     X  X   |          5 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  91                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7|            |
                                           | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X        X  X     X  X  X        X  X  X  X  X  X  X  X     X  X  X|         37 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Mesothelioma Benign                  |                               X                                          |          1 |
      Mesothelioma Malignant               |                               X  X                 X                     |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  92                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|             
                                           | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |       X                                                                  |             
      Leiomyosarcoma, Metastatic, Mesentery| X                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                X              X  X        X        X  X  X  X           X|             
      Hepatocellular Carcinoma, Multiple   |    X        X     X                    X                                 |             
      Hepatocellular Adenoma               |                                                                X         |             
      Hepatocellular Adenoma, Multiple     | X     X  X  X  X  X  X           X     X  X  X  X  X  X  X  X        X   |             
      Leukemia Mononuclear                 |    X     X  X  X  X                 X        X     X     X     X  X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                            X                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +        +                          +           +      |             
      Fibrosarcoma                         | X                                                                        |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Mesothelioma Malignant               |                   X                                                      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                            X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                            X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                              X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|             
                                           | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X                                                                     |             
      Pheochromocytoma Benign              |                         X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                       X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                            X                                             |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      C-Cell, Carcinoma                    |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Mesothelioma Malignant       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Adenoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X        X  X  X     X  X  X  X     X  X  X  X  X  X  X  X  X  X     X  X|             
      Interstitial Cell, Adenoma           |    X  X           X              X                                X      |             
      Tunic, Mesothelioma Malignant        |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |    X     X  X     X                 X                 X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |                                                          X               |             
      Inguinal, Leukemia Mononuclear       |                                                                   X      |             
      Mandibular, Leukemia Mononuclear     |    X     X  X  X                    X        X        X  X  X  X  X      |             
      Mediastinal, Leukemia Mononuclear    |             X                                                     X      |             
      Pancreatic, Leukemia Mononuclear     |    X        X                                                            |             
      Renal, Leukemia Mononuclear          |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                                         +           +      |             
      Leukemia Mononuclear                 |             X                                         X           X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X  X  X                 X        X     X  X  X     X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  M  +  +  M  +  +|             
      Leukemia Mononuclear                 |             X                                         X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|             
                                           | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                              X                           |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                         X|             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                             X            |             
      Subcutaneous Tissue, Hemangioma      |       X                                                                  |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Neurofibroma    |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                 X                        |             
      Leukemia Mononuclear                 |    X     X  X                                         X        X  X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                            X                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X                                X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X  X  X                 X        X     X  X  X  X  X  X      |             
      Mesothelioma Malignant               |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3|            |
                                           | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Leiomyosarcoma, Metastatic, Mesentery|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |    X  X                                X                                 |         12 |
      Hepatocellular Carcinoma, Multiple   |             X                    X              X                        |          7 |
      Hepatocellular Adenoma               |                                                          X               |          2 |
      Hepatocellular Adenoma, Multiple     |    X  X  X  X  X  X  X  X  X     X     X  X  X  X  X        X     X  X  X|         36 |
      Leukemia Mononuclear                 | X     X  X  X           X     X  X     X  X        X  X  X  X  X  X  X  X|         28 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fibrosarcoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  96                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3|            |
                                           | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
      Pheochromocytoma Benign              |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |                         X           X                                X   |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Adenoma                      |    X  X  X     X  X              X     X                                 |          8 |
      C-Cell, Adenoma, Multiple            |                                                    X                     |          1 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X              X     X  X  X  X  X     X     X     X  X|         37 |
      Interstitial Cell, Adenoma           |                      X     X  X                             X            |          9 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        | X                             X                    X  X                 X|         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     | X     X  X  X           X     X                    X  X  X  X  X  X     X|         24 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  97                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3|            |
                                           | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear    | X           X        X                                         X         |          6 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                    +                     |   4        |
      Leukemia Mononuclear                 |                                                    X                     |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X  X        X  X     X  X     X  X        X  X  X  X  X  X  X  X|         30 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|  40        |
      Leukemia Mononuclear                 |                                                                X         |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +        +     +  +     +        +  +  +     +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                        X                                 |          1 |
      Subcutaneous Tissue, Fibroma         |                                        X                                 |          2 |
      Subcutaneous Tissue, Fibroma,        |                                                                          |            |
          Multiple                         |                X  X                                                      |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                            X                                             |          2 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                         X                                                |          1 |
      Subcutaneous Tissue, Neurofibroma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                      X  X|          3 |
      Leukemia Mononuclear                 | X     X                 X              X           X  X  X           X  X|         15 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  98                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3|            |
                                           | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +              +        +        +                  |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X  X        X  X     X  X     X  X        X  X  X  X  X  X  X  X|         31 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  99                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                         X  X              X           X  X               |             
      Hepatocellular Carcinoma, Multiple   | X           X                                                  X  X      |             
      Hepatocellular Adenoma               |                   X                                                      |             
      Hepatocellular Adenoma, Multiple     | X  X  X  X  X  X     X     X     X        X  X  X  X  X     X  X  X  X   |             
      Leukemia Mononuclear                 |    X  X  X  X           X  X     X  X  X  X  X  X  X  X  X  X  X     X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Squamous Cell Carcinoma              | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Schwannoma Malignant                 | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |    X                                X                                   X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                X                                   X|             
      Pheochromocytoma Benign              |                X                             X                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                    X|             
      Pars Distalis, Adenoma               | X  X     X                    X                             X            |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      C-Cell, Adenoma                      | X        X        X                                X                     |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
      Carcinoma                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X  X     X     X     X     X  X  X  X  X  X  X  X  X  X  X  X|             
      Interstitial Cell, Adenoma           |                   X     X           X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |    X  X  X              X  X        X     X                             X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |    X  X  X  X           X  X     X  X  X           X     X        X  X  X|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                                                           +|             
      Leukemia Mononuclear                 |             X                                                           X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X  X           X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  M  +  +  +  M  M  +  M  I  +  +  +  M  M  M  +  +  +  +  M  M  +  +|             
      Leukemia Mononuclear                 |             X           X                                               X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +     +           +     +  +  +  +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                X                                X                        |             
      Subcutaneous Tissue, Fibroma         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteosarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
      Rhabdomyosarcoma                     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Oligodendroglioma Malignant          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 |    X  X  X  X              X        X  X  X           X  X     X        X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                   +                                +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Renal Tubule, Adenoma                |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X  X           X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7|            |
                             DAY ON TEST   | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3|            |
                                           | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  48        |
      Leiomyoma                            |       X                                X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |    X  X     X     X        X  X           X           X                  |         13 |
      Hepatocellular Carcinoma, Multiple   | X              X                    X                    X     X        X|         10 |
      Hepatocellular Adenoma               |                                        X              X                  |          3 |
      Hepatocellular Adenoma, Multiple     |    X  X  X  X  X  X     X  X  X     X     X     X        X  X  X     X  X|         35 |
      Leukemia Mononuclear                 |    X  X  X  X     X  X  X     X  X     X  X  X  X           X  X     X   |         35 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                         +                              |   2        |
      Hemangiosarcoma                      |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X  X     X  X  X                                      X         |          7 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                    X                     |          1 |
      Leukemia Mononuclear                 |          X  X     X  X  X              X     X              X  X         |         12 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X  X     X  X  X              X     X              X  X         |         12 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 103                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7|            |
                             DAY ON TEST   | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3|            |
                                           | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenoma                              |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |       X                       X     X     X                              |          9 |
      Pars Intermedia, Adenoma             |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                X        X              X        X              X  X     X|         11 |
      C-Cell, Carcinoma                    |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |    X     X                                            X           X      |          5 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma|    X        X  X           X  X  X  X  X  X  X  X  X  X  X     X        X|         36 |
      Interstitial Cell, Adenoma           |       X  X        X  X  X                                   X        X   |         10 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        |    X                 X  X        X     X     X              X  X     X   |         17 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Mandibular, Leukemia Mononuclear     |    X  X  X  X  X  X  X  X        X     X        X           X        X   |         27 |
      Mediastinal, Leukemia Mononuclear    |                                        X        X                        |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X  X  X     X  X  X     X  X     X  X  X  X           X  X     X   |         36 |
      Osteosarcoma, Metastatic, Bone       |                                                    X                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 104                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7|            |
                             DAY ON TEST   | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3|            |
                                           | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  M  M  +  +  M  +  +  M  +  M  +  +  +  +  M  +  M  +  +  +  M  M|  28        |
      Leukemia Mononuclear                 |                                                 X              X         |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +        +  +        +  +        +     +     +  +     +     +  +|  30        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |             X                       X                                    |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Osteosarcoma                  |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Rhabdomyosarcoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Oligodendroglioma Malignant          |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                                                                         X|          1 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                              X                           |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           | X                          X                                   X         |          3 |
      Leukemia Mononuclear                 |          X  X     X  X  X        X     X  X  X  X           X  X         |         24 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   4        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          2 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 105                                                               
NTP Experiment-Test: 05077-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/10/97  
Route: DOSED FEED                                                                                                 Time: 08:19:31  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7|            |
                             DAY ON TEST   | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3|            |
                                           | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|     A      |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X  X  X  X  X  X  X     X  X     X  X  X  X           X  X     X   |         37 |
 __________________________________________________________________________________________________________________________________