TDMS Study 05077-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) FIREMASTER FF-1 POLYBROMINATED BIPHENYL NTP Experiment-Test: 05077-01 Report: PEIRPT05 Study Type: CHRONIC Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 Facility: Battelle Columbus Laboratory Chemical CAS #: 67774327 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 50 50 Early Deaths Moribund Sacrifice 10 10 9 12 8 10 Natural Death 1 1 2 3 2 Survivors Terminal Sacrifice 40 39 39 36 39 38 Moribund Sacrifice 1 Animals Examined Microscopically 50 50 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (50) (10) (11) (13) (10) (12) Leiomyosarcoma 1 (10%) Intestine Small, Duodenum (50) (12) (11) (13) (10) (12) Schwannoma Malignant 1 (8%) Serosa, Adenocarcinoma, Metastatic, Uterus 1 (8%) Liver (50) (50) (50) (50) (50) (50) Hepatocellular Carcinoma 2 (4%) 1 (2%) 7 (14%) Hepatocellular Carcinoma, Multiple 1 (2%) Hepatocellular Adenoma 2 (4%) 6 (12%) 12 (24%) 15 (30%) Hepatocellular Adenoma, Multiple 1 (2%) 4 (8%) 10 (20%) 20 (40%) Hepatocholangiocarcinoma 1 (2%) Mesentery (2) (1) (1) (1) (1) (4) Hepatocellular Carcinoma, Metastatic, Liver 1 (25%) Pancreas (49) (12) (11) (13) (9) (12) Adenocarcinoma, Metastatic, Uterus 1 (8%) Stomach (50) (49) (50) (50) (50) (50) Serosa, Adenocarcinoma, Metastatic, Uterus 1 (2%) Stomach, Forestomach (50) (49) (50) (50) (50) (49) Squamous Cell Carcinoma 1 (2%) Stomach, Glandular (50) (48) (50) (50) (50) (50) Sarcoma 1 (2%) Tongue (1) (1) (1) (1) (1) Carcinoma, Metastatic, Zymbal's Gland 1 (100%) Squamous Cell Carcinoma 1 (100%) 1 (100%) Squamous Cell Papilloma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (11) (12) (14) (11) (12) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (11) (12) (14) (9) (12) Capsule, Adenocarcinoma, Metastatic, Uterus 1 (9%) Adrenal Gland, Cortex (50) (10) (12) (14) (9) (12) Adenoma 1 (2%) 1 (10%) Adrenal Gland, Medulla (48) (10) (12) (13) (9) (12) Pheochromocytoma Malignant 1 (8%) Pheochromocytoma Benign 2 (4%) 1 (8%) Bilateral, Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (49) (12) (11) (13) (9) (12) Carcinoma 1 (8%) Parathyroid Gland (46) (9) (11) (14) (9) (10) Adenoma 2 (4%) Pituitary Gland (50) (34) (27) (29) (28) (27) Pars Distalis, Adenoma 21 (42%) 19 (56%) 19 (70%) 18 (62%) 12 (43%) 12 (44%) Pars Intermedia, Adenoma 2 (7%) 1 (4%) Thyroid Gland (50) (12) (15) (14) (10) (13) Bilateral, C-Cell, Adenoma 1 (2%) C-Cell, Adenoma 10 (20%) 4 (33%) 4 (27%) 3 (21%) 2 (15%) C-Cell, Adenoma, Moderate 1 (8%) C-Cell, Carcinoma 1 (8%) 2 (13%) 1 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) Liposarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (50) (15) (12) (16) (10) (13) Adenoma 3 (6%) 1 (7%) 1 (6%) 1 (8%) Bilateral, Adenoma 1 (7%) Ovary (50) (23) (19) (22) (14) (20) Granulosa-Theca Tumor Malignant 1 (5%) Periovarian Tissue, Adenocarcinoma, Metastatic, Uterus 1 (4%) Periovarian Tissue, Leiomyoma 1 (5%) Uterus (50) (17) (18) (18) (21) (20) Adenocarcinoma 2 (4%) 1 (6%) 2 (11%) Polyp Stromal 7 (14%) 4 (24%) 2 (11%) 3 (17%) 6 (29%) 4 (20%) Page 3 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont Sarcoma Stromal 1 (6%) Schwannoma Malignant 1 (2%) Epithelium, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (11) (11) (13) (9) (11) Lymph Node (50) (11) (11) (14) (12) (12) Mediastinal, Adenocarcinoma, Metastatic, Uterus 1 (9%) Lymph Node, Mesenteric (4) (2) (3) (1) (1) (3) Adenocarcinoma, Metastatic, Uterus 1 (50%) Spleen (50) (50) (50) (50) (49) (49) Thymus (44) (9) (11) (11) (9) (10) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (48) (16) (13) (21) (16) (11) Adenoma 1 (6%) Carcinoma 1 (6%) Fibroadenoma 4 (8%) 7 (44%) 2 (15%) 10 (48%) 7 (44%) 2 (18%) Fibroadenoma, Multiple 1 (8%) 1 (5%) Skin (50) (11) (12) (13) (11) (14) Basal Cell Adenoma 1 (2%) Squamous Cell Papilloma 1 (2%) Trichoepithelioma 1 (2%) Subcutaneous Tissue, Fibroma 1 (9%) Subcutaneous Tissue, Fibrosarcoma 1 (8%) 3 (21%) Subcutaneous Tissue, Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (1) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (11) (11) (14) (10) (12) Astrocytoma Malignant 2 (4%) 1 (7%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (11) (11) (14) (9) (11) Adenocarcinoma, Metastatic, Uterus 1 (9%) 1 (9%) Hepatocellular Carcinoma, Metastatic, Liver 1 (9%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) (1) Carcinoma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (11) (11) (14) (11) (12) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) *(50) *(50) Leukemia Mononuclear 14 (28%) 13 (26%) 20 (40%) 22 (44%) 17 (34%) 27 (54%) Lymphoma Malignant Lymphocytic 1 (2%) Mesothelioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 40 37 35 42 41 49 Total Primary Neoplasms 77 58 61 80 70 96 Total Animals with Benign Neoplasms 34 30 25 33 34 41 Total Benign Neoplasms 56 40 33 49 49 56 Total Animals with Malignant Neoplasms 20 16 25 28 20 31 Total Malignant Neoplasms 21 18 28 31 21 40 Total Animals with Metastatic Neoplasms 1 1 2 Total Metastatic Neoplasm 8 1 3 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 Early Deaths Natural Death 5 2 Moribund Sacrifice 10 15 Survivors Terminal Sacrifice 34 32 Natural Death 1 1 Animals Examined Microscopically 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (50) (50) Hepatocellular Carcinoma 4 (8%) 16 (32%) Hepatocellular Carcinoma, Multiple 6 (12%) Hepatocellular Adenoma 1 (2%) 1 (2%) Hepatocellular Adenoma, Multiple 37 (74%) 44 (88%) Hepatocholangiocarcinoma 1 (2%) Pancreas (50) (50) Stomach, Forestomach (48) (50) Squamous Cell Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (49) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (50) (50) Adenoma 1 (2%) Bilateral, Adenoma 1 (2%) Adrenal Gland, Medulla (49) (49) Pituitary Gland (50) (50) Pars Distalis, Adenoma 2 (4%) 5 (10%) Pars Distalis, Adenoma, Mild 1 (2%) Pars Distalis, Adenoma, Moderate 1 (2%) Thyroid Gland (48) (48) Bilateral, C-Cell, Adenoma 1 (2%) C-Cell, Adenoma 2 (4%) 7 (15%) C-Cell, Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (47) (46) Carcinoma 1 (2%) 1 (2%) Ovary (48) (49) Leiomyosarcoma 1 (2%) Uterus (49) (50) Adenocarcinoma 1 (2%) Leiomyosarcoma 1 (2%) Polyp Stromal 7 (14%) 4 (8%) Sarcoma Stromal 1 (2%) Vagina (2) Leiomyosarcoma 1 (50%) Polyp 1 (50%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (48) (47) Lymph Node (49) (47) Lymph Node, Mesenteric (5) Spleen (50) (50) Thymus (41) (42) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (49) (48) Adenoma 1 (2%) Fibroadenoma 1 (2%) 4 (8%) Fibroadenoma, Multiple 1 (2%) Skin (49) (50) Squamous Cell Papilloma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (47) (50) Alveolar/Bronchiolar Adenoma 2 (4%) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Squamous Cell Carcinoma, Multiple, Metastatic, Uncertain Primary Site 1 (2%) Squamous Cell Carcinoma, Metastatic, Clitoral Gland 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) Transitional Epithelium, Carcinoma 1 (2%) Urinary Bladder (49) (50) Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) Leukemia Mononuclear 23 (46%) 25 (50%) Lymphoma Malignant Histiocytic 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 9 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 47 50 Total Primary Neoplasms 90 125 Total Animals with Benign Neoplasms 41 46 Total Benign Neoplasms 59 71 Total Animals with Malignant Neoplasms 27 36 Total Malignant Neoplasms 31 54 Total Animals with Metastatic Neoplasms 2 1 Total Metastatic Neoplasm 2 1 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 10 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 50 50 50 Early Deaths Natural Death 5 4 1 6 5 4 Moribund Sacrifice 16 16 15 21 25 26 Survivors Natural Death 1 Terminal Sacrifice 29 29 34 22 19 19 Moribund Sacrifice 1 1 1 Animals Examined Microscopically 50 50 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (48) (20) (16) (26) (30) (29) Intestine Large, Colon (49) (21) (16) (27) (31) (30) Intestine Large, Rectum (49) (21) (16) (27) (30) (30) Intestine Small, Duodenum (48) (21) (16) (27) (31) (30) Intestine Small, Ileum (49) (19) (16) (28) (29) (29) Adenocarcinoma 1 (2%) 1 (4%) Intestine Small, Jejunum (49) (20) (16) (27) (30) (30) Adenocarcinoma 1 (4%) Liver (50) (50) (50) (49) (50) (50) Adenocarcinoma, Metastatic, Prostate 1 (2%) Adenocarcinoma, Metastatic, Intestine Small 1 (2%) Fibrosarcoma, Metastatic, Skin 1 (2%) Hepatocellular Carcinoma 1 (2%) 2 (4%) 1 (2%) 1 (2%) Hepatocellular Adenoma 1 (2%) 4 (8%) 3 (6%) 4 (8%) 6 (12%) 10 (20%) Hepatocellular Adenoma, Multiple 1 (2%) 2 (4%) 6 (12%) 7 (14%) 6 (12%) Mesentery (6) (3) (1) (2) Adenocarcinoma, Metastatic, Prostate 1 (17%) Lipoma 1 (50%) Pancreas (49) (21) (16) (27) (32) (31) Acinus, Adenoma 1 (2%) 1 (6%) 1 (4%) 3 (9%) 1 (3%) Salivary Glands (50) (21) (16) (27) (30) (30) Schwannoma Malignant 1 (2%) Stomach, Forestomach (50) (49) (48) (49) (50) (50) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) 1 (2%) Stomach, Glandular (50) (48) (48) (48) (50) (49) Carcinoid Tumor Malignant 1 (2%) Tongue (1) Squamous Cell Carcinoma 1 (100%) Tooth (1) Gingiva, Squamous Cell Carcinoma 1 (100%) Page 11 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (21) (16) (27) (31) (31) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (50) (21) (15) (28) (31) (30) Adrenal Gland, Medulla (49) (22) (16) (29) (32) (30) Pheochromocytoma Malignant 1 (2%) 1 (3%) 1 (3%) 1 (3%) Pheochromocytoma Complex 1 (5%) 1 (6%) Pheochromocytoma Benign 11 (22%) 4 (18%) 1 (6%) 1 (3%) 2 (6%) 3 (10%) Bilateral, Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (49) (21) (16) (27) (31) (30) Adenoma 4 (8%) 1 (5%) 1 (4%) 1 (3%) Carcinoma 3 (6%) Parathyroid Gland (43) (21) (16) (27) (31) (29) Adenoma 1 (4%) 2 (7%) Pituitary Gland (50) (27) (22) (32) (30) (34) Pars Distalis, Adenoma 13 (26%) 7 (26%) 9 (41%) 11 (34%) 9 (30%) 11 (32%) Pars Distalis, Adenoma, Multiple 1 (3%) Pars Nervosa, Astrocytoma Malignant, Metastatic, Brain 1 (4%) Thyroid Gland (49) (23) (17) (28) (31) (30) Bilateral, C-Cell, Adenoma 1 (2%) 1 (4%) 1 (4%) Bilateral, Follicular Cell, Adenoma 1 (3%) C-Cell, Adenoma 16 (33%) 3 (13%) 4 (24%) 8 (29%) 3 (10%) 8 (27%) C-Cell, Carcinoma 1 (2%) 2 (9%) 1 (6%) 3 (10%) Follicular Cell, Adenoma 1 (2%) 1 (4%) 2 (6%) Follicular Cell, Carcinoma 2 (9%) 1 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) Chordoma 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (20) (16) (28) (30) (30) Adenocarcinoma, Metastatic, Prostate 1 (5%) Preputial Gland (47) (25) (20) (32) (34) (32) Adenoma 4 (9%) 1 (4%) 1 (5%) 1 (3%) Carcinoma 3 (6%) 3 (12%) 3 (15%) 4 (13%) 4 (12%) 2 (6%) Duct, Squamous Cell Papilloma 1 (2%) Page 12 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont Prostate (50) (21) (16) (28) (30) (31) Adenocarcinoma 1 (5%) Testes (50) (49) (50) (50) (50) (50) Bilateral, Interstitial Cell, Adenoma 43 (86%) 41 (84%) 43 (86%) 45 (90%) 37 (74%) 42 (84%) Interstitial Cell, Adenoma 6 (12%) 5 (10%) 4 (8%) 4 (8%) 9 (18%) 5 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (21) (15) (27) (31) (30) Lymph Node (50) (23) (18) (27) (33) (31) Mediastinal, Adenocarcinoma, Metastatic, Prostate 1 (4%) Mediastinal, Fibrosarcoma, Metastatic, Skin 1 (3%) Lymph Node, Mesenteric (2) (3) (2) (9) (8) (4) Adenocarcinoma, Metastatic, Prostate 1 (33%) Fibrosarcoma, Metastatic, Skin 1 (50%) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (50%) Spleen (50) (50) (49) (49) (50) (50) Fibrosarcoma 1 (2%) Osteosarcoma, Metastatic, Bone 1 (2%) Thymus (47) (17) (15) (22) (24) (27) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (39) (14) (14) (23) (20) (18) Fibroadenoma 1 (3%) 2 (14%) 4 (17%) Skin (50) (26) (22) (31) (32) (32) Basosquamous Tumor Benign 1 (3%) Fibroma 1 (3%) Keratoacanthoma 2 (4%) 1 (5%) Squamous Cell Papilloma 1 (2%) 1 (3%) Trichoepithelioma 1 (3%) 1 (3%) Sebaceous Gland, Adenoma 1 (5%) Subcutaneous Tissue, Fibroma 5 (10%) 2 (8%) 6 (27%) 1 (3%) 4 (13%) 2 (6%) Subcutaneous Tissue, Fibroma, Multiple 1 (2%) Subcutaneous Tissue, Fibrosarcoma 2 (4%) 4 (15%) 3 (14%) 2 (6%) 1 (3%) 1 (3%) Subcutaneous Tissue, Neurofibrosarcoma 1 (3%) ____________________________________________________________________________________________________________________________________ Page 13 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (21) (16) (28) (31) (31) Femur, Hemangiosarcoma 1 (3%) Femur, Osteosarcoma 1 (6%) Lumbar, Osteosarcoma 1 (3%) Rib, Osteosarcoma 1 (5%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (21) (16) (29) (31) (31) Astrocytoma Malignant 1 (5%) Glioma Malignant 1 (3%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (21) (17) (28) (32) (31) Adenocarcinoma, Metastatic, Prostate 1 (5%) Alveolar/Bronchiolar Adenoma 2 (4%) 2 (12%) 1 (4%) 1 (3%) Alveolar/Bronchiolar Carcinoma 1 (6%) 1 (4%) 1 (3%) Carcinoma Adenosquamous 1 (3%) 1 (3%) Chordoma, Metastatic, Uncertain Primary Site 1 (6%) Fibrosarcoma, Metastatic, Skin 1 (6%) 1 (3%) Osteosarcoma, Metastatic, Bone 1 (6%) Osteosarcoma, Metastatic, Uncertain Primary Site 1 (2%) Pheochromocytoma Complex, Metastatic, Adrenal Gland 1 (6%) Mediastinum, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (6%) Nose (50) (21) (16) (27) (31) (30) Submucosa, Glands, Adenocarcinoma 2 (10%) Trachea (50) (21) (16) (27) (31) (31) Peritracheal Tissue, Fibrosarcoma, Metastatic, Skin 1 (3%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ Page 14 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (24) (20) (32) (32) (37) Medulla, Sarcoma 1 (2%) Renal Tubule, Adenoma 1 (4%) 2 (6%) Renal Tubule, Carcinoma 1 (2%) Urinary Bladder (49) (20) (17) (27) (31) (30) Adenocarcinoma, Metastatic, Prostate 1 (5%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) *(50) *(50) *(50) Leukemia Mononuclear 25 (50%) 32 (64%) 32 (64%) 33 (66%) 41 (82%) 37 (74%) Lymphoma Malignant Histiocytic 1 (2%) Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%) Mesothelioma Benign 1 (2%) 1 (2%) Mesothelioma Malignant 1 (2%) 5 (10%) 2 (4%) 1 (2%) 3 (6%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 15 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM 0-0 10-0 1-1 0-3 3-3 10-3 ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 50 50 50 50 50 50 Total Primary Neoplasms 157 130 124 145 144 144 Total Animals with Benign Neoplasms 50 47 48 50 47 48 Total Benign Neoplasms 116 72 80 94 88 95 Total Animals with Malignant Neoplasms 34 42 39 41 43 41 Total Malignant Neoplasms 41 58 44 51 56 49 Total Animals with Metastatic Neoplasms 2 3 5 1 1 Total Metastatic Neoplasm 4 9 6 1 3 Total Animals with Malignant Neoplasms 1 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 16 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 Early Deaths Moribund Sacrifice 23 24 Natural Death 3 7 Survivors Moribund Sacrifice 1 1 Terminal Sacrifice 23 18 Animals Examined Microscopically 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Jejunum (48) (48) Leiomyoma 2 (4%) Leiomyosarcoma 1 (2%) Leiomyosarcoma, Metastatic, Mesentery 1 (2%) Liver (50) (50) Hepatocellular Carcinoma 12 (24%) 13 (26%) Hepatocellular Carcinoma, Multiple 7 (14%) 10 (20%) Hepatocellular Adenoma 2 (4%) 3 (6%) Hepatocellular Adenoma, Multiple 36 (72%) 35 (70%) Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%) Mesentery (5) (2) Fibrosarcoma 1 (20%) Hemangiosarcoma 1 (50%) Squamous Cell Carcinoma, Metastatic, Stomach 1 (20%) Pancreas (49) (50) Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%) Stomach, Forestomach (50) (50) Squamous Cell Carcinoma 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (49) Schwannoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (50) (50) Adenoma 1 (2%) Adrenal Gland, Medulla (50) (50) Pheochromocytoma Benign 2 (4%) 3 (6%) Page 17 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Islets, Pancreatic (49) (50) Adenoma 2 (4%) 1 (2%) Parathyroid Gland (49) (47) Adenoma 2 (4%) Pituitary Gland (48) (49) Pars Distalis, Adenoma 4 (8%) 9 (18%) Pars Intermedia, Adenoma 1 (2%) Thyroid Gland (49) (49) C-Cell, Adenoma 8 (16%) 11 (22%) C-Cell, Adenoma, Multiple 1 (2%) C-Cell, Carcinoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) Preputial Gland (44) (49) Adenoma 1 (2%) 1 (2%) Carcinoma 5 (10%) Testes (50) (50) Bilateral, Interstitial Cell, Adenoma 37 (74%) 36 (72%) Interstitial Cell, Adenoma 9 (18%) 10 (20%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) Lymph Node (49) (49) Deep Cervical, Carcinoma, Metastatic, Thyroid Gland 1 (2%) Lymph Node, Mesenteric (4) (2) Spleen (50) (50) Osteosarcoma, Metastatic, Bone 1 (2%) Thymus (40) (28) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) 2 (4%) Subcutaneous Tissue, Fibroma 2 (4%) 3 (6%) Page 18 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont Subcutaneous Tissue, Fibroma, Multiple 2 (4%) Subcutaneous Tissue, Fibrosarcoma 2 (4%) Subcutaneous Tissue, Hemangioma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) Subcutaneous Tissue, Neurofibroma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) Femur, Osteosarcoma 1 (2%) Skeletal Muscle (1) Rhabdomyosarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) Oligodendroglioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (49) Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 3 (6%) Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) Renal Tubule, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) Leukemia Mononuclear 31 (62%) 37 (74%) Mesothelioma Malignant 1 (2%) * Number of animals with any tissue examined microscopically Page 19 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont Multiple Organs *(50) *(50) ____________________________________________________________________________________________________________________________________ Page 20 NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94 Route: DOSED FEED Time: 05:22:32 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 30 PPM 30 PPM 0-10 10-10 ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 50 50 Total Primary Neoplasms 171 196 Total Animals with Benign Neoplasms 49 49 Total Benign Neoplasms 113 123 Total Animals with Malignant Neoplasms 42 47 Total Malignant Neoplasms 58 73 Total Animals with Metastatic Neoplasms 3 4 Total Metastatic Neoplasm 6 4 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 21 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 125654-125654/125654 --multipart-boundary--